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Wyszukujesz frazę ""MutL Protein Homolog 1"" wg kryterium: Wszystkie pola


Tytuł :
Lynch syndrome-associated repeated stroke with MLH1 frame-shift mutation.
Autorzy :
Zhang M; Department of Neurology, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China.
Yang H; Department of Neurology, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China.
Chen Z; Department of Neurology, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China.
Fan Y; Department of Neurology, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China.
Hu X; Department of Neurology, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China.
Liu W; Department of Neurology, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China. .
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Źródło :
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2021 Apr; Vol. 42 (4), pp. 1631-1635. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Colorectal Neoplasms, Hereditary Nonpolyposis*/complications
Colorectal Neoplasms, Hereditary Nonpolyposis*/diagnostic imaging
Colorectal Neoplasms, Hereditary Nonpolyposis*/genetics
MutL Protein Homolog 1*/genetics
Stroke*
Adult ; DNA Mismatch Repair ; Female ; Genetic Predisposition to Disease ; Humans ; Mutation
Czasopismo naukowe
Tytuł :
MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway.
Autorzy :
Guan J; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Lu C; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Jin Q; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Lu H; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Chen X; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Tian L; Department of Cancer Biology, Basser Center for BRCA, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Zhang Y; Department of Biochemistry & Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, USA.
Ortega J; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Zhang J; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Siteni S; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Chen M; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Gu L; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Shay JW; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Davis AJ; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Chen ZJ; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Fu YX; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: .
Li GM; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: .
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Źródło :
Cancer cell [Cancer Cell] 2021 Jan 11; Vol. 39 (1), pp. 109-121.e5. Date of Electronic Publication: 2020 Dec 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromosome Aberrations*
Signal Transduction*
DNA Repair Enzymes/*metabolism
Exodeoxyribonucleases/*metabolism
MutL Protein Homolog 1/*deficiency
Neoplasms/*genetics
Animals ; Cell Line, Tumor ; DNA Breaks, Single-Stranded ; DNA Mismatch Repair ; DNA Repair ; DNA, Single-Stranded/metabolism ; HeLa Cells ; Humans ; Membrane Proteins/metabolism ; Mice ; MutL Protein Homolog 1/metabolism ; Neoplasms/metabolism ; Nucleotidyltransferases/metabolism ; Replication Protein A/metabolism
Czasopismo naukowe
Tytuł :
Protons and High-Linear Energy Transfer Radiation Induce Genetically Similar Lymphomas With High Penetrance in a Mouse Model of the Aging Human Hematopoietic System.
Autorzy :
Patel R; Department of Radiation Oncology, Duke University, Durham, North Carolina.
Zhang L; Department of Medicine, Case Western Reserve University, Cleveland, Ohio.
Desai A; Department of Medicine, Case Western Reserve University, Cleveland, Ohio; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio.
Hoenerhoff MJ; Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, Michigan.
Kennedy LH; Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, Michigan.
Radivoyevitch T; Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio.
La Tessa C; University of Trento, Trento, Italy; Trento Institute for Fundamental Physics and Applications TIFPA-INFN, Trento, Italy.
Gerson SL; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio.
Welford SM; Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida; Department of Radiation Oncology, University of Miami, Miami, Florida. Electronic address: .
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Źródło :
International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 2020 Nov 15; Vol. 108 (4), pp. 1091-1102. Date of Electronic Publication: 2020 Jul 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Linear Energy Transfer*
Hematopoietic System/*radiation effects
Lymphoma/*genetics
MutL Protein Homolog 1/*deficiency
Neoplasms, Radiation-Induced/*genetics
Protons/*adverse effects
Silicon/*adverse effects
Aging ; Animals ; DNA Mismatch Repair ; Disease Models, Animal ; Female ; Gene Expression Profiling ; Hematopoietic System/physiology ; Humans ; Lymphoma/pathology ; Male ; Mice ; MutL Protein Homolog 1/genetics ; Neoplasms, Radiation-Induced/pathology ; Penetrance ; Radiation Exposure/adverse effects ; Sequence Analysis, RNA/methods ; Space Flight ; Whole-Body Irradiation/adverse effects ; Whole-Body Irradiation/methods
Czasopismo naukowe
Tytuł :
Comparisons of screening strategies for identifying Lynch syndrome among patients with MLH1-deficient colorectal cancer.
Autorzy :
Xiao B; Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, 510060, China.
Luo J; Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences; Cancer Hospital of the University of Chinese Academy of Sciences; Zhejiang Cancer Hospital, Zhejiang, China.
Xie E; Department of General Surgery, the Affiliated Shantou Hospital of Sun Yat-sen University, Guangdong, 515000, China.
Kong L; Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, 510060, China.
Tang J; Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, 510060, China.
Liu D; Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, 510060, China.
Mao L; Guangzhou Kingmed Diagnostics Group Co., Ltd. Clinical Genome Center, KingMed Center for Clinical Laboratory Co., Ltd., Guangzhou, China.
Sui Q; Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, 510060, China.
Li W; Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, 510060, China.
Hong Z; Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, 510060, China.
Pan Z; Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, 510060, China. .
Jiang W; Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, 510060, China. .
Ding PR; Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, 510060, China. .
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Źródło :
European journal of human genetics : EJHG [Eur J Hum Genet] 2020 Nov; Vol. 28 (11), pp. 1555-1562. Date of Electronic Publication: 2020 Jul 13.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Colorectal Neoplasms, Hereditary Nonpolyposis/*genetics
Genetic Testing/*methods
MutL Protein Homolog 1/*deficiency
Colorectal Neoplasms, Hereditary Nonpolyposis/diagnosis ; Costs and Cost Analysis ; DNA Methylation ; Female ; Genetic Testing/economics ; Genetic Testing/standards ; Humans ; Male ; Middle Aged ; MutL Protein Homolog 1/genetics ; Mutation ; Proto-Oncogene Proteins B-raf
Czasopismo naukowe
Tytuł :
Identification of a novel pathogenic MLH1 mutation and recommended genetic screening strategy: An investigation of three Chinese Lynch syndrome pedigrees.
Autorzy :
Li F; Department of General Surgery, The Second Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Xia Y; Department of General Surgery, The Second Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Wang G; Department of General Surgery, The Second Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Tang C; Department of General Surgery, The Second Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Zhan T; Department of General Surgery, The Second Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Shen J; Department of General Surgery, The Second Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Zhang J; Department of General Surgery, The Second Affiliated Hospital, Nanjing Medical University, Nanjing, China.
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Źródło :
Molecular genetics & genomic medicine [Mol Genet Genomic Med] 2020 Aug; Vol. 8 (8), pp. e1295. Date of Electronic Publication: 2020 Jun 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Colorectal Neoplasms, Hereditary Nonpolyposis/*genetics
Genetic Testing/*methods
MutL Protein Homolog 1/*genetics
Cells, Cultured ; China ; Colorectal Neoplasms, Hereditary Nonpolyposis/diagnosis ; Genetic Testing/standards ; Humans ; Loss of Function Mutation ; MutL Protein Homolog 1/chemistry ; MutL Protein Homolog 1/metabolism ; Pedigree ; Protein Domains ; RNA Stability
Czasopismo naukowe
Tytuł :
MLH1 intronic variants mapping to + 5 position of splice donor sites lead to deleterious effects on RNA splicing.
Autorzy :
Piñero TA; Instituto de Medicina Traslacional e Ingeniería Biomédica (IMTIB) [HIBA-IUHI-CONICET], C1199ABH, Buenos Aires, Argentina.; Programa de Cáncer Hereditario (Pro.Can.He.), Hospital Italiano de Buenos Aires, C1199ABH, Buenos Aires, Argentina.
Soukarieh O; Inserm U1245, IRIB, UNIROUEN, Normandie Univ, Normandy Centre for Genomic and Personalized Medicine, 76183, Rouen Cedex 1, France.
Rolain M; Inserm U1245, IRIB, UNIROUEN, Normandie Univ, Normandy Centre for Genomic and Personalized Medicine, 76183, Rouen Cedex 1, France.
Alvarez K; Laboratorio de Oncología y Genética Molecular, Unidad de Coloproctología, Clínica Las Condes, 7591046, Santiago de Chile, Chile.
López-Köstner F; Laboratorio de Oncología y Genética Molecular, Unidad de Coloproctología, Clínica Las Condes, 7591046, Santiago de Chile, Chile.
Torrezan GT; Genomic and Molecular Biology Group, International Research Center, A. C. Camargo Cancer Center, São Paulo, 01508-010, Brazil.
Carraro DM; Genomic and Molecular Biology Group, International Research Center, A. C. Camargo Cancer Center, São Paulo, 01508-010, Brazil.
De Oliveira Nascimento IL; Laboratório de Imunologia e Biología Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, BA, 40110-902, Brazil.
Bomfim TF; Laboratório de Imunologia e Biología Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, BA, 40110-902, Brazil.
Machado-Lopes TMB; Laboratório de Imunologia e Biología Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, BA, 40110-902, Brazil.
Freitas JC; Laboratório de Imunologia e Biología Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, BA, 40110-902, Brazil.; Departamento de Ciências da Vida, Universidade do Estado da Bahia, Salvador, BA, 41150-000, Brazil.
Toralles MB; Laboratório de Imunologia e Biología Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, BA, 40110-902, Brazil.
Sandes KA; Laboratório de Imunologia e Biología Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, BA, 40110-902, Brazil.
Rossi BM; Hospital Sirio Libanes, São Paulo, 01308-050, Brazil.
Junior SA; Colorectal Tumor Nucleus of the Pelvic Surgery Department, A.C. Camargo Cancer Center, São Paulo, SP, 01509-010, Brazil.
Meira J; Hospital Universitário Prof. Edgard Santos, Universidade Federal da Bahia, Salvador, 40301-155, Brazil.
Dominguez-Valentin M; Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, 0369, Oslo, Norway.; Instituto de Investigación, Universidad Católica de Trujillo, Chimbote, Peru.
Møller P; Department of Tumor Biology, The Norwegian Radium Hospital, Part of Oslo University Hospital, 0369, Oslo, Norway.
Vaccaro CA; Instituto de Medicina Traslacional e Ingeniería Biomédica (IMTIB) [HIBA-IUHI-CONICET], C1199ABH, Buenos Aires, Argentina.; Programa de Cáncer Hereditario (Pro.Can.He.), Hospital Italiano de Buenos Aires, C1199ABH, Buenos Aires, Argentina.
Martins A; Inserm U1245, IRIB, UNIROUEN, Normandie Univ, Normandy Centre for Genomic and Personalized Medicine, 76183, Rouen Cedex 1, France.
Pavicic WH; Instituto de Medicina Traslacional e Ingeniería Biomédica (IMTIB) [HIBA-IUHI-CONICET], C1199ABH, Buenos Aires, Argentina. .; Programa de Cáncer Hereditario (Pro.Can.He.), Hospital Italiano de Buenos Aires, C1199ABH, Buenos Aires, Argentina. .
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Źródło :
Familial cancer [Fam Cancer] 2020 Oct; Vol. 19 (4), pp. 323-336.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Introns*
RNA Splice Sites*
RNA Splicing*
Colorectal Neoplasms, Hereditary Nonpolyposis/*genetics
MutL Protein Homolog 1/*genetics
Adult ; Argentina ; Brazil ; Chile ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms, Hereditary Nonpolyposis/metabolism ; DNA Mismatch Repair ; Exons ; Female ; Genetic Counseling ; Humans ; Male ; Middle Aged ; Mismatch Repair Endonuclease PMS2/deficiency ; Mismatch Repair Endonuclease PMS2/genetics ; Mismatch Repair Endonuclease PMS2/metabolism ; MutL Protein Homolog 1/deficiency ; MutL Protein Homolog 1/metabolism ; Pedigree ; Protein Isoforms
Czasopismo naukowe
Tytuł :
Combined Gemcitabine and Immune-Checkpoint Inhibition Conquers Anti-PD-L1 Resistance in Low-Immunogenic Mismatch Repair-Deficient Tumors.
Autorzy :
Salewski I; Department of Medicine, Clinic III-Hematology, Oncology, Palliative Medicine, Rostock University Medical Center, University of Rostock, 18057 Rostock, Germany.
Henne J; Department of Medicine, Clinic III-Hematology, Oncology, Palliative Medicine, Rostock University Medical Center, University of Rostock, 18057 Rostock, Germany.
Engster L; Department of Medicine, Clinic III-Hematology, Oncology, Palliative Medicine, Rostock University Medical Center, University of Rostock, 18057 Rostock, Germany.
Schneider B; Institute of Pathology, Rostock University Medical Center, University of Rostock, 18057 Rostock, Germany.
Lemcke H; Department of Cardiac Surgery, Reference and Translation Center for Cardiac Stem Cell Therapy (RTC), Rostock University Medical Center, University of Rostock, 18057 Rostock, Germany.; Faculty of Interdisciplinary Research, Department Life, Light & Matter, University Rostock, 18057 Rostock, Germany.
Skorska A; Department of Cardiac Surgery, Reference and Translation Center for Cardiac Stem Cell Therapy (RTC), Rostock University Medical Center, University of Rostock, 18057 Rostock, Germany.; Faculty of Interdisciplinary Research, Department Life, Light & Matter, University Rostock, 18057 Rostock, Germany.
Berlin P; Division of Gastroenterology and Endocrinology, Department of Medicine II, Rostock University Medical Center, University of Rostock, 18057 Rostock, Germany.
Henze L; Department of Medicine, Clinic III-Hematology, Oncology, Palliative Medicine, Rostock University Medical Center, University of Rostock, 18057 Rostock, Germany.
Junghanss C; Department of Medicine, Clinic III-Hematology, Oncology, Palliative Medicine, Rostock University Medical Center, University of Rostock, 18057 Rostock, Germany.
Maletzki C; Department of Medicine, Clinic III-Hematology, Oncology, Palliative Medicine, Rostock University Medical Center, University of Rostock, 18057 Rostock, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 01; Vol. 22 (11). Date of Electronic Publication: 2021 Jun 01.
Typ publikacji :
Journal Article
MeSH Terms :
B7-H1 Antigen/*genetics
Brain Neoplasms/*drug therapy
Colorectal Neoplasms/*drug therapy
Colorectal Neoplasms, Hereditary Nonpolyposis/*drug therapy
MutL Protein Homolog 1/*genetics
Neoplastic Syndromes, Hereditary/*drug therapy
Animals ; B7-H1 Antigen/antagonists & inhibitors ; B7-H1 Antigen/immunology ; Brain Neoplasms/blood ; Brain Neoplasms/genetics ; Brain Neoplasms/immunology ; Chemokine CCL4/blood ; Colorectal Neoplasms/blood ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/immunology ; Colorectal Neoplasms, Hereditary Nonpolyposis/blood ; Colorectal Neoplasms, Hereditary Nonpolyposis/genetics ; Colorectal Neoplasms, Hereditary Nonpolyposis/immunology ; DNA Mismatch Repair/genetics ; Deoxycytidine/analogs & derivatives ; Deoxycytidine/pharmacology ; Disease Models, Animal ; Drug Resistance, Neoplasm/genetics ; Humans ; Immune Checkpoint Inhibitors/pharmacology ; Interleukin-13/blood ; Lymphocytes, Tumor-Infiltrating/metabolism ; Lymphocytes, Tumor-Infiltrating/pathology ; Mice ; Myeloid-Derived Suppressor Cells ; Neoplastic Syndromes, Hereditary/blood ; Neoplastic Syndromes, Hereditary/genetics ; Neoplastic Syndromes, Hereditary/immunology ; T-Lymphocytes, Cytotoxic/metabolism ; T-Lymphocytes, Cytotoxic/pathology ; Tumor Necrosis Factor-alpha/blood
SCR Disease Name :
Turcot syndrome
Czasopismo naukowe
Tytuł :
Dynamics of genomic and immune responses during primary immunotherapy resistance in mismatch repair-deficient tumors.
Autorzy :
Takahashi N; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.
Rajapakse VN; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.
Pongor L; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.
Kumar S; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.
Tlemsani C; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.
Erwin-Cohen R; Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA.
Young HA; Laboratory of Cancer Immunometabolism, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA.
Hewitt S; Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.
Wei JS; Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.
Khan J; Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.
Villarino AV; Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA.
Trepel JB; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.
Thomas A; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.
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Źródło :
Cold Spring Harbor molecular case studies [Cold Spring Harb Mol Case Stud] 2020 Oct 07; Vol. 6 (5). Date of Electronic Publication: 2020 Oct 07 (Print Publication: 2020).
Typ publikacji :
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Janus Kinase 1/*genetics
MutL Protein Homolog 1/*genetics
Neoplasms/*metabolism
Biomarkers, Tumor/genetics ; DNA Mismatch Repair/genetics ; DNA Mismatch Repair/physiology ; Female ; Genomics ; Humans ; Immunity/immunology ; Immunotherapy/methods ; Janus Kinase 1/metabolism ; Microsatellite Instability ; Middle Aged ; MutL Protein Homolog 1/metabolism ; Mutation
Czasopismo naukowe
Tytuł :
Regulation of the MLH1-MLH3 endonuclease in meiosis.
Autorzy :
Cannavo E; Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana (USI), Bellinzona, Switzerland.
Sanchez A; Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana (USI), Bellinzona, Switzerland.
Anand R; Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana (USI), Bellinzona, Switzerland.
Ranjha L; Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana (USI), Bellinzona, Switzerland.
Hugener J; Department of Biology, Institute of Biochemistry, Eidgenössische Technische Hochschule (ETH), Zürich, Switzerland.
Adam C; Institut Curie, PSL Research University, CNRS UMR3244, Paris, France.; Paris Sorbonne Université, Paris, France.
Acharya A; Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana (USI), Bellinzona, Switzerland.; Department of Biology, Institute of Biochemistry, Eidgenössische Technische Hochschule (ETH), Zürich, Switzerland.
Weyland N; Institute of Molecular Cancer Research, University of Zürich, Zürich, Switzerland.
Aran-Guiu X; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK.
Charbonnier JB; I2BC, iBiTec-S, CEA, CNRS UMR 9198, Université Paris-Sud, Gif-sur-Yvette, France.; Université Paris Sud, Orsay, France.
Hoffmann ER; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK.; DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Borde V; Institut Curie, PSL Research University, CNRS UMR3244, Paris, France.; Paris Sorbonne Université, Paris, France.
Matos J; Department of Biology, Institute of Biochemistry, Eidgenössische Technische Hochschule (ETH), Zürich, Switzerland.
Cejka P; Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana (USI), Bellinzona, Switzerland. .; Department of Biology, Institute of Biochemistry, Eidgenössische Technische Hochschule (ETH), Zürich, Switzerland. .
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Źródło :
Nature [Nature] 2020 Oct; Vol. 586 (7830), pp. 618-622. Date of Electronic Publication: 2020 Aug 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Crossing Over, Genetic*
Meiosis*
Endonucleases/*metabolism
MutL Protein Homolog 1/*metabolism
MutL Proteins/*metabolism
Amino Acid Motifs ; Amino Acid Sequence ; Cell Cycle Proteins/metabolism ; Chromosomes, Human/genetics ; Conserved Sequence ; DNA/metabolism ; DNA Cleavage ; DNA Repair Enzymes/metabolism ; DNA, Cruciform/metabolism ; Exodeoxyribonucleases/metabolism ; Humans ; MutL Protein Homolog 1/chemistry ; MutL Proteins/chemistry ; MutS Proteins/metabolism ; Proliferating Cell Nuclear Antigen/metabolism ; Replication Protein C/metabolism
Czasopismo naukowe
Tytuł :
DNMT1 promotes cell proliferation via methylating hMLH1 and hMSH2 promoters in EGFR-mutated non-small cell lung cancer.
Autorzy :
Wu XY; Department of Respiration, Jinhua Guangfu Cancer Hospital, No. 1296, North Huancheng Rd, Wucheng District, Jinhua, Zhejiang 321000, China.
Chen HC; Department of Respiration, Jinhua Guangfu Cancer Hospital, No. 1296, North Huancheng Rd, Wucheng District, Jinhua, Zhejiang 321000, China.
Li WW; Department of Respiration, Jinhua Guangfu Cancer Hospital, No. 1296, North Huancheng Rd, Wucheng District, Jinhua, Zhejiang 321000, China.
Yan JD; Department of Respiration, Jinhua Guangfu Cancer Hospital, No. 1296, North Huancheng Rd, Wucheng District, Jinhua, Zhejiang 321000, China.
Lv RY; Department of Respiration, Jinhua Guangfu Cancer Hospital, No. 1296, North Huancheng Rd, Wucheng District, Jinhua, Zhejiang 321000, China.
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Źródło :
Journal of biochemistry [J Biochem] 2020 Aug 01; Vol. 168 (2), pp. 151-157.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Methylation*
Promoter Regions, Genetic*
Carcinoma, Non-Small-Cell Lung/*genetics
DNA (Cytosine-5-)-Methyltransferase 1/*metabolism
Lung Neoplasms/*genetics
MutL Protein Homolog 1/*genetics
MutS Homolog 2 Protein/*genetics
A549 Cells ; Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Proliferation ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Female ; Humans ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Male ; Middle Aged ; MutL Protein Homolog 1/metabolism ; MutS Homolog 2 Protein/metabolism ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Enhanced Tumoral MLH1-Expression in MLH1-/PMS2-Deficient Colon Cancer Is Indicative of Sporadic Colon Cancer and Not HNPCC.
Autorzy :
Tarancón-Diez M; Institute of Pathology, University of Cologne Medical School, Kerpener Str. 62, 50937, Cologne, Germany.
Büttner R; Institute of Pathology, University of Cologne Medical School, Kerpener Str. 62, 50937, Cologne, Germany.
Friedrichs N; Institute of Pathology, University of Cologne Medical School, Kerpener Str. 62, 50937, Cologne, Germany. .
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Źródło :
Pathology oncology research : POR [Pathol Oncol Res] 2020 Jul; Vol. 26 (3), pp. 1435-1439. Date of Electronic Publication: 2019 Jan 06.
Typ publikacji :
Journal Article
MeSH Terms :
Biomarkers, Tumor/*analysis
Colonic Neoplasms/*diagnosis
Colorectal Neoplasms, Hereditary Nonpolyposis/*diagnosis
MutL Protein Homolog 1/*biosynthesis
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Female ; Humans ; Immunohistochemistry/methods ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Mismatch Repair Endonuclease PMS2/analysis ; Mismatch Repair Endonuclease PMS2/biosynthesis ; MutL Protein Homolog 1/analysis ; Retrospective Studies ; Young Adult
Czasopismo naukowe
Tytuł :
Prediction Model for Gastric Cancer With DNA Mismatch Repair Deficiency.
Autorzy :
Suzuki O; Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan; .
Yamaguchi T; Department of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan.; Department of Clinical Genetics, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan.
Fukuchi M; Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
Mochiki E; Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
Arai T; Department of Pathology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan.
Akagi K; Division of Molecular Diagnosis and Cancer Prevention, Saitama Cancer Center, Saitama, Japan.
Ishida H; Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
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Źródło :
Anticancer research [Anticancer Res] 2021 Feb; Vol. 41 (2), pp. 975-982.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Mismatch Repair*
DNA-Binding Proteins/*deficiency
Mismatch Repair Endonuclease PMS2/*deficiency
MutL Protein Homolog 1/*deficiency
Stomach Neoplasms/*pathology
Adult ; Aged ; Aged, 80 and over ; Area Under Curve ; Biomarkers, Tumor/metabolism ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Grading ; Neoplasm Invasiveness ; Sex Characteristics ; Stomach Neoplasms/metabolism ; Tumor Burden ; Young Adult
Czasopismo naukowe
Tytuł :
Mismatch repair protein and MLH1 methylation status as predictors of response to adjuvant therapy in endometrial cancer.
Autorzy :
Loukovaara M; Department of Obstetrics and Gynecology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Pasanen A; Department of Pathology, Faculty of Medicine, Helsinki University Hospital and Research Program in Applied Tumor Genomics, University of Helsinki, Helsinki, Finland.
Bützow R; Department of Obstetrics and Gynecology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.; Department of Pathology, Faculty of Medicine, Helsinki University Hospital and Research Program in Applied Tumor Genomics, University of Helsinki, Helsinki, Finland.
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Źródło :
Cancer medicine [Cancer Med] 2021 Feb; Vol. 10 (3), pp. 1034-1042. Date of Electronic Publication: 2021 Jan 15.
Typ publikacji :
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Methylation*
Mutation*
Biomarkers, Tumor/*genetics
Chemoradiotherapy, Adjuvant/*mortality
DNA Repair Enzymes/*genetics
Endometrial Neoplasms/*pathology
MutL Protein Homolog 1/*genetics
Aged ; DNA Mismatch Repair ; Endometrial Neoplasms/drug therapy ; Endometrial Neoplasms/genetics ; Female ; Follow-Up Studies ; Gene Expression Regulation, Neoplastic ; Humans ; Middle Aged ; Prognosis ; Retrospective Studies ; Survival Rate
Czasopismo naukowe
Tytuł :
Lymphocyte-activation gene 3 expression associates with poor prognosis and immunoevasive contexture in Epstein-Barr virus-positive and MLH1-defective gastric cancer patients.
Autorzy :
Lv K; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Li R; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Cao Y; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Gu Y; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Liu X; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
He X; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Jin K; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Fang H; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Fei Y; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Shi M; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Liu H; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Li H; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
He H; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Lin C; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Zhang H; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Xu J; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
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Źródło :
International journal of cancer [Int J Cancer] 2021 Feb 01; Vol. 148 (3), pp. 759-768. Date of Electronic Publication: 2020 Nov 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigens, CD/*metabolism
Epstein-Barr Virus Infections/*genetics
MutL Protein Homolog 1/*deficiency
Stomach Neoplasms/*virology
Cohort Studies ; Epstein-Barr Virus Infections/immunology ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Prognosis ; Stomach Neoplasms/genetics ; Stomach Neoplasms/metabolism ; Survival Analysis
Czasopismo naukowe
Tytuł :
Coexistent Dedifferentiated Endometrioid Carcinoma of the Uterus and Adenocarcinoma of the Bladder in Lynch Syndrome: Case Report and Review of the Literature.
Autorzy :
Groth JV; Departments of Pathology.
Prabhu S; Department of Pathology, Northwestern University, Chicago, IL.
Periakaruppan R; Departments of Pathology.
Ohlander S; Urology.
Emmadi R; Departments of Pathology.
Kothari R; Obstetrics and Gynecology, University of Illinois Hospital & Health Sciences System.
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Źródło :
Applied immunohistochemistry & molecular morphology : AIMM [Appl Immunohistochem Mol Morphol] 2020 Mar; Vol. 28 (3), pp. e26-e30.
Typ publikacji :
Case Reports; Journal Article; Review
MeSH Terms :
Adenocarcinoma*/diagnostic imaging
Adenocarcinoma*/genetics
Adenocarcinoma*/metabolism
Adenocarcinoma*/surgery
Carcinoma, Endometrioid*/diagnostic imaging
Carcinoma, Endometrioid*/genetics
Carcinoma, Endometrioid*/metabolism
Carcinoma, Endometrioid*/surgery
Colorectal Neoplasms, Hereditary Nonpolyposis*/diagnostic imaging
Colorectal Neoplasms, Hereditary Nonpolyposis*/genetics
Colorectal Neoplasms, Hereditary Nonpolyposis*/surgery
Endometrial Neoplasms*/diagnostic imaging
Endometrial Neoplasms*/genetics
Endometrial Neoplasms*/metabolism
Endometrial Neoplasms*/surgery
MutL Protein Homolog 1*/genetics
MutL Protein Homolog 1*/metabolism
Mutation, Missense*
Neoplasm Proteins*/genetics
Neoplasm Proteins*/metabolism
Neoplasms, Second Primary*/diagnostic imaging
Neoplasms, Second Primary*/genetics
Neoplasms, Second Primary*/metabolism
Neoplasms, Second Primary*/surgery
Urinary Bladder Neoplasms*/diagnostic imaging
Urinary Bladder Neoplasms*/genetics
Urinary Bladder Neoplasms*/surgery
Amino Acid Substitution ; Female ; Humans ; Middle Aged
Czasopismo naukowe
Tytuł :
Human MutLγ, the MLH1-MLH3 heterodimer, is an endonuclease that promotes DNA expansion.
Autorzy :
Kadyrova LY; Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, IL 62901.
Gujar V; Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, IL 62901.
Burdett V; Department of Biochemistry, Duke University Medical Center, Durham, NC 27710.
Modrich PL; Department of Biochemistry, Duke University Medical Center, Durham, NC 27710; .; Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710.
Kadyrov FA; Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, IL 62901; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Feb 18; Vol. 117 (7), pp. 3535-3542. Date of Electronic Publication: 2020 Feb 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
MutL Protein Homolog 1/*metabolism
MutL Proteins/*metabolism
DNA Mismatch Repair ; Dimerization ; Endonucleases/chemistry ; Endonucleases/genetics ; Endonucleases/metabolism ; Humans ; MutL Protein Homolog 1/chemistry ; MutL Protein Homolog 1/genetics ; MutL Proteins/chemistry ; MutL Proteins/genetics ; Trinucleotide Repeat Expansion
Czasopismo naukowe
Tytuł :
Extracellular vesicles transmitted miR-31-5p promotes sorafenib resistance by targeting MLH1 in renal cell carcinoma.
Autorzy :
He J; Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.; Department of Head and Neck Cancer, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
He J; State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Min L; Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
He Y; Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Guan H; Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Wang J; Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Peng X; Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
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Źródło :
International journal of cancer [Int J Cancer] 2020 Feb 15; Vol. 146 (4), pp. 1052-1063. Date of Electronic Publication: 2019 Jul 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Renal Cell/*drug therapy
Extracellular Vesicles/*metabolism
MicroRNAs/*metabolism
MutL Protein Homolog 1/*metabolism
Sorafenib/*pharmacology
Animals ; Antineoplastic Agents/pharmacology ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/metabolism ; Extracellular Vesicles/genetics ; Humans ; Kidney Neoplasms/drug therapy ; Kidney Neoplasms/genetics ; Kidney Neoplasms/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; MutL Protein Homolog 1/biosynthesis ; MutL Protein Homolog 1/genetics ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Correlation of MLH1 polymorphisms, survival statistics, in silico assessment and gene downregulation with clinical outcomes among breast cancer cases.
Autorzy :
Malik SS; Fatima Jinnah Women University, The Mall Rawalpindi, Rawalpindi, Pakistan. .; Armed Forces Institute of Pathology, Rawalpindi, Pakistan. .
Zia A; National Centre for Bioinformatics, Quaid-i-Azam University, Islamabad, Pakistan.
Mubarik S; Department of Epidemiology and Biostatistics, School of Health Sciences, Wuhan University, Wuhan, China.
Masood N; Fatima Jinnah Women University, The Mall Rawalpindi, Rawalpindi, Pakistan.
Rashid S; National Centre for Bioinformatics, Quaid-i-Azam University, Islamabad, Pakistan.
Sherrard A; Department of Cellular and Molecular Medicine, School of Life Sciences, Bristol University, Bristol, UK.
Khan MB; Armed Forces Institute of Pathology, Rawalpindi, Pakistan.
Khadim MT; Armed Forces Institute of Pathology, Rawalpindi, Pakistan.
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Źródło :
Molecular biology reports [Mol Biol Rep] 2020 Jan; Vol. 47 (1), pp. 683-692. Date of Electronic Publication: 2019 Nov 08.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms*/chemistry
Breast Neoplasms*/genetics
Breast Neoplasms*/mortality
MutL Protein Homolog 1*/analysis
MutL Protein Homolog 1*/chemistry
MutL Protein Homolog 1*/genetics
MutL Protein Homolog 1*/metabolism
Adult ; Breast/chemistry ; DNA Mutational Analysis ; Down-Regulation/genetics ; Female ; Humans ; Middle Aged ; Polymorphism, Single Nucleotide/genetics
Czasopismo naukowe
Tytuł :
Nucleus-specific linker histones Hho1 and Mlh1 form distinct protein interactions during growth, starvation and development in Tetrahymena thermophila.
Autorzy :
Nabeel-Shah S; Department of Chemistry and Biology, Ryerson University, 350 Victoria St., Toronto, M5B 2K3, Canada.; Donnelly Centre, University of Toronto, Toronto, M5S 3E1, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, M5S 1A8, Canada.
Ashraf K; Department of Biology, York University, 4700 Keele St., Toronto, M3J 1P3, Canada.
Saettone A; Department of Chemistry and Biology, Ryerson University, 350 Victoria St., Toronto, M5B 2K3, Canada.
Garg J; Department of Biology, York University, 4700 Keele St., Toronto, M3J 1P3, Canada.
Derynck J; Department of Chemistry and Biology, Ryerson University, 350 Victoria St., Toronto, M5B 2K3, Canada.
Lambert JP; Department of Molecular Medicine and Cancer Research Centre, Université Laval, Quebec, Canada.; CHU de Québec Research Center, CHUL, 2705 Laurier Boulevard, Quebec, G1V 4G2, Canada.
Pearlman RE; Department of Biology, York University, 4700 Keele St., Toronto, M3J 1P3, Canada. .
Fillingham J; Department of Chemistry and Biology, Ryerson University, 350 Victoria St., Toronto, M5B 2K3, Canada. .
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Źródło :
Scientific reports [Sci Rep] 2020 Jan 13; Vol. 10 (1), pp. 168. Date of Electronic Publication: 2020 Jan 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Developmental*
High Mobility Group Proteins/*metabolism
Histones/*metabolism
MutL Protein Homolog 1/*metabolism
Proteome/*analysis
Protozoan Proteins/*metabolism
Tetrahymena thermophila/*growth & development
Amino Acid Sequence ; Animals ; Cell Nucleus/genetics ; Cell Nucleus/metabolism ; Chromatin/genetics ; Chromatin/metabolism ; Gene Expression Regulation ; High Mobility Group Proteins/genetics ; MutL Protein Homolog 1/genetics ; Protein Interaction Domains and Motifs ; Protozoan Proteins/genetics ; Starvation ; Tetrahymena thermophila/genetics ; Tetrahymena thermophila/metabolism
Czasopismo naukowe
Tytuł :
Highly sensitive MLH1 methylation analysis in blood identifies a cancer patient with low-level mosaic MLH1 epimutation.
Autorzy :
Dámaso E; Hereditary Cancer Program, Catalan Institute of Oncology, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), ONCOBELL Program, Av. Gran Via de l'Hospitalet, 199-203, 08908 L' Hospitalet de Llobregat, Barcelona, Spain.
Canet-Hermida J; Hereditary Cancer Program, Catalan Institute of Oncology, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), ONCOBELL Program, Av. Gran Via de l'Hospitalet, 199-203, 08908 L' Hospitalet de Llobregat, Barcelona, Spain.
Vargas-Parra G; Hereditary Cancer Program, Catalan Institute of Oncology, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), ONCOBELL Program, Av. Gran Via de l'Hospitalet, 199-203, 08908 L' Hospitalet de Llobregat, Barcelona, Spain.; Department of General and Digestive Surgery, Dr Josep Trueta University Hospital, Girona, Spain.
Velasco À; Department of General and Digestive Surgery, Dr Josep Trueta University Hospital, Girona, Spain.; Hereditary Cancer Program, Catalan Institute of Oncology, Institut d'Investigació Biomèdica de Girona (IDIBGI), Girona, Spain.
Marín F; Hereditary Cancer Program, Catalan Institute of Oncology, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), ONCOBELL Program, Av. Gran Via de l'Hospitalet, 199-203, 08908 L' Hospitalet de Llobregat, Barcelona, Spain.; Department of General and Digestive Surgery, Dr Josep Trueta University Hospital, Girona, Spain.
Darder E; Hereditary Cancer Program, Catalan Institute of Oncology, Institut d'Investigació Biomèdica de Girona (IDIBGI), Girona, Spain.
Del Valle J; Hereditary Cancer Program, Catalan Institute of Oncology, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), ONCOBELL Program, Av. Gran Via de l'Hospitalet, 199-203, 08908 L' Hospitalet de Llobregat, Barcelona, Spain.; Department of General and Digestive Surgery, Dr Josep Trueta University Hospital, Girona, Spain.
Fernández A; Hereditary Cancer Program, Catalan Institute of Oncology, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), ONCOBELL Program, Av. Gran Via de l'Hospitalet, 199-203, 08908 L' Hospitalet de Llobregat, Barcelona, Spain.
Izquierdo À; Hereditary Cancer Program, Catalan Institute of Oncology, Institut d'Investigació Biomèdica de Girona (IDIBGI), Girona, Spain.
Mateu G; Pathology Department, Dr Josep Trueta University Hospital, Girona, Spain.
Oliveras G; Pathology Department, Dr Josep Trueta University Hospital, Girona, Spain.
Escribano C; Pathology Department, Clínica Girona, Girona, Spain.
Piñol V; Department of Gastroenterology, Dr Josep Trueta University Hospital, Girona, Spain.
Uchima HI; Department of Gastroenterology, Dr Josep Trueta University Hospital, Girona, Spain.
Soto JL; Hereditary Cancer Program Valencian Region, Molecular Genetics Laboratory, Elche University Hospital, Elche, Alicante, Spain.
Hitchins M; Department of Biomedical Sciences, Cedars-Sinai Medical Center, CA, Los Angeles, USA.
Farrés R; Department of General and Digestive Surgery, Dr Josep Trueta University Hospital, Girona, Spain.
Lázaro C; Hereditary Cancer Program, Catalan Institute of Oncology, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), ONCOBELL Program, Av. Gran Via de l'Hospitalet, 199-203, 08908 L' Hospitalet de Llobregat, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.
Queralt B; Department of Medical Oncology, Catalan Institute of Oncology, Girona, Spain.
Brunet J; Hereditary Cancer Program, Catalan Institute of Oncology, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), ONCOBELL Program, Av. Gran Via de l'Hospitalet, 199-203, 08908 L' Hospitalet de Llobregat, Barcelona, Spain.; Hereditary Cancer Program, Catalan Institute of Oncology, Institut d'Investigació Biomèdica de Girona (IDIBGI), Girona, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.; Department of Medical Sciences Department, School of Medicine, University of Girona, Girona, Spain.
Capellá G; Hereditary Cancer Program, Catalan Institute of Oncology, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), ONCOBELL Program, Av. Gran Via de l'Hospitalet, 199-203, 08908 L' Hospitalet de Llobregat, Barcelona, Spain. .; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain. .
Pineda M; Hereditary Cancer Program, Catalan Institute of Oncology, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), ONCOBELL Program, Av. Gran Via de l'Hospitalet, 199-203, 08908 L' Hospitalet de Llobregat, Barcelona, Spain. .; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain. .
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Źródło :
Clinical epigenetics [Clin Epigenetics] 2019 Nov 28; Vol. 11 (1), pp. 171. Date of Electronic Publication: 2019 Nov 28.
Typ publikacji :
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Methylation*
Mutation*
Colorectal Neoplasms/*genetics
Genetic Testing/*methods
MutL Protein Homolog 1/*genetics
Adult ; Colorectal Neoplasms/blood ; DNA/blood ; Female ; Humans ; Male ; Middle Aged ; Mosaicism ; MutL Protein Homolog 1/blood ; Promoter Regions, Genetic ; Young Adult
Czasopismo naukowe

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