Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""MutL Protein Homolog 1"" wg kryterium: Wszystkie pola


Tytuł :
Lynch syndrome-associated repeated stroke with MLH1 frame-shift mutation.
Autorzy :
Zhang M; Department of Neurology, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China.
Yang H; Department of Neurology, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China.
Chen Z; Department of Neurology, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China.
Fan Y; Department of Neurology, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China.
Hu X; Department of Neurology, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China.
Liu W; Department of Neurology, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China. .
Pokaż więcej
Źródło :
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2021 Apr; Vol. 42 (4), pp. 1631-1635. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Colorectal Neoplasms, Hereditary Nonpolyposis*/complications
Colorectal Neoplasms, Hereditary Nonpolyposis*/diagnostic imaging
Colorectal Neoplasms, Hereditary Nonpolyposis*/genetics
MutL Protein Homolog 1*/genetics
Stroke*
Adult ; DNA Mismatch Repair ; Female ; Genetic Predisposition to Disease ; Humans ; Mutation
Czasopismo naukowe
Tytuł :
Protons and High-Linear Energy Transfer Radiation Induce Genetically Similar Lymphomas With High Penetrance in a Mouse Model of the Aging Human Hematopoietic System.
Autorzy :
Patel R; Department of Radiation Oncology, Duke University, Durham, North Carolina.
Zhang L; Department of Medicine, Case Western Reserve University, Cleveland, Ohio.
Desai A; Department of Medicine, Case Western Reserve University, Cleveland, Ohio; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio.
Hoenerhoff MJ; Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, Michigan.
Kennedy LH; Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, Michigan.
Radivoyevitch T; Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio.
La Tessa C; University of Trento, Trento, Italy; Trento Institute for Fundamental Physics and Applications TIFPA-INFN, Trento, Italy.
Gerson SL; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio.
Welford SM; Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida; Department of Radiation Oncology, University of Miami, Miami, Florida. Electronic address: .
Pokaż więcej
Źródło :
International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 2020 Nov 15; Vol. 108 (4), pp. 1091-1102. Date of Electronic Publication: 2020 Jul 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Linear Energy Transfer*
Hematopoietic System/*radiation effects
Lymphoma/*genetics
MutL Protein Homolog 1/*deficiency
Neoplasms, Radiation-Induced/*genetics
Protons/*adverse effects
Silicon/*adverse effects
Aging ; Animals ; DNA Mismatch Repair ; Disease Models, Animal ; Female ; Gene Expression Profiling ; Hematopoietic System/physiology ; Humans ; Lymphoma/pathology ; Male ; Mice ; MutL Protein Homolog 1/genetics ; Neoplasms, Radiation-Induced/pathology ; Penetrance ; Radiation Exposure/adverse effects ; Sequence Analysis, RNA/methods ; Space Flight ; Whole-Body Irradiation/adverse effects ; Whole-Body Irradiation/methods
Czasopismo naukowe
Tytuł :
Comparisons of screening strategies for identifying Lynch syndrome among patients with MLH1-deficient colorectal cancer.
Autorzy :
Xiao B; Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, 510060, China.
Luo J; Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences; Cancer Hospital of the University of Chinese Academy of Sciences; Zhejiang Cancer Hospital, Zhejiang, China.
Xie E; Department of General Surgery, the Affiliated Shantou Hospital of Sun Yat-sen University, Guangdong, 515000, China.
Kong L; Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, 510060, China.
Tang J; Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, 510060, China.
Liu D; Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, 510060, China.
Mao L; Guangzhou Kingmed Diagnostics Group Co., Ltd. Clinical Genome Center, KingMed Center for Clinical Laboratory Co., Ltd., Guangzhou, China.
Sui Q; Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, 510060, China.
Li W; Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, 510060, China.
Hong Z; Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, 510060, China.
Pan Z; Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, 510060, China. .
Jiang W; Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, 510060, China. .
Ding PR; Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, 510060, China. .
Pokaż więcej
Źródło :
European journal of human genetics : EJHG [Eur J Hum Genet] 2020 Nov; Vol. 28 (11), pp. 1555-1562. Date of Electronic Publication: 2020 Jul 13.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Colorectal Neoplasms, Hereditary Nonpolyposis/*genetics
Genetic Testing/*methods
MutL Protein Homolog 1/*deficiency
Colorectal Neoplasms, Hereditary Nonpolyposis/diagnosis ; Costs and Cost Analysis ; DNA Methylation ; Female ; Genetic Testing/economics ; Genetic Testing/standards ; Humans ; Male ; Middle Aged ; MutL Protein Homolog 1/genetics ; Mutation ; Proto-Oncogene Proteins B-raf
Czasopismo naukowe
Tytuł :
Dynamics of genomic and immune responses during primary immunotherapy resistance in mismatch repair-deficient tumors.
Autorzy :
Takahashi N; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.
Rajapakse VN; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.
Pongor L; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.
Kumar S; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.
Tlemsani C; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.
Erwin-Cohen R; Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA.
Young HA; Laboratory of Cancer Immunometabolism, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA.
Hewitt S; Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.
Wei JS; Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.
Khan J; Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.
Villarino AV; Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA.
Trepel JB; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.
Thomas A; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.
Pokaż więcej
Źródło :
Cold Spring Harbor molecular case studies [Cold Spring Harb Mol Case Stud] 2020 Oct 07; Vol. 6 (5). Date of Electronic Publication: 2020 Oct 07 (Print Publication: 2020).
Typ publikacji :
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Janus Kinase 1/*genetics
MutL Protein Homolog 1/*genetics
Neoplasms/*metabolism
Biomarkers, Tumor/genetics ; DNA Mismatch Repair/genetics ; DNA Mismatch Repair/physiology ; Female ; Genomics ; Humans ; Immunity/immunology ; Immunotherapy/methods ; Janus Kinase 1/metabolism ; Microsatellite Instability ; Middle Aged ; MutL Protein Homolog 1/metabolism ; Mutation
Czasopismo naukowe
Tytuł :
Regulation of the MLH1-MLH3 endonuclease in meiosis.
Autorzy :
Cannavo E; Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana (USI), Bellinzona, Switzerland.
Sanchez A; Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana (USI), Bellinzona, Switzerland.
Anand R; Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana (USI), Bellinzona, Switzerland.
Ranjha L; Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana (USI), Bellinzona, Switzerland.
Hugener J; Department of Biology, Institute of Biochemistry, Eidgenössische Technische Hochschule (ETH), Zürich, Switzerland.
Adam C; Institut Curie, PSL Research University, CNRS UMR3244, Paris, France.; Paris Sorbonne Université, Paris, France.
Acharya A; Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana (USI), Bellinzona, Switzerland.; Department of Biology, Institute of Biochemistry, Eidgenössische Technische Hochschule (ETH), Zürich, Switzerland.
Weyland N; Institute of Molecular Cancer Research, University of Zürich, Zürich, Switzerland.
Aran-Guiu X; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK.
Charbonnier JB; I2BC, iBiTec-S, CEA, CNRS UMR 9198, Université Paris-Sud, Gif-sur-Yvette, France.; Université Paris Sud, Orsay, France.
Hoffmann ER; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK.; DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Borde V; Institut Curie, PSL Research University, CNRS UMR3244, Paris, France.; Paris Sorbonne Université, Paris, France.
Matos J; Department of Biology, Institute of Biochemistry, Eidgenössische Technische Hochschule (ETH), Zürich, Switzerland.
Cejka P; Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana (USI), Bellinzona, Switzerland. .; Department of Biology, Institute of Biochemistry, Eidgenössische Technische Hochschule (ETH), Zürich, Switzerland. .
Pokaż więcej
Źródło :
Nature [Nature] 2020 Oct; Vol. 586 (7830), pp. 618-622. Date of Electronic Publication: 2020 Aug 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Crossing Over, Genetic*
Meiosis*
Endonucleases/*metabolism
MutL Protein Homolog 1/*metabolism
MutL Proteins/*metabolism
Amino Acid Motifs ; Amino Acid Sequence ; Cell Cycle Proteins/metabolism ; Chromosomes, Human/genetics ; Conserved Sequence ; DNA/metabolism ; DNA Cleavage ; DNA Repair Enzymes/metabolism ; DNA, Cruciform/metabolism ; Exodeoxyribonucleases/metabolism ; Humans ; MutL Protein Homolog 1/chemistry ; MutL Proteins/chemistry ; MutS Proteins/metabolism ; Proliferating Cell Nuclear Antigen/metabolism ; Replication Protein C/metabolism
Czasopismo naukowe
Tytuł :
Identification of a novel pathogenic MLH1 mutation and recommended genetic screening strategy: An investigation of three Chinese Lynch syndrome pedigrees.
Autorzy :
Li F; Department of General Surgery, The Second Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Xia Y; Department of General Surgery, The Second Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Wang G; Department of General Surgery, The Second Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Tang C; Department of General Surgery, The Second Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Zhan T; Department of General Surgery, The Second Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Shen J; Department of General Surgery, The Second Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Zhang J; Department of General Surgery, The Second Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Pokaż więcej
Źródło :
Molecular genetics & genomic medicine [Mol Genet Genomic Med] 2020 Aug; Vol. 8 (8), pp. e1295. Date of Electronic Publication: 2020 Jun 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Colorectal Neoplasms, Hereditary Nonpolyposis/*genetics
Genetic Testing/*methods
MutL Protein Homolog 1/*genetics
Cells, Cultured ; China ; Colorectal Neoplasms, Hereditary Nonpolyposis/diagnosis ; Genetic Testing/standards ; Humans ; Loss of Function Mutation ; MutL Protein Homolog 1/chemistry ; MutL Protein Homolog 1/metabolism ; Pedigree ; Protein Domains ; RNA Stability
Czasopismo naukowe
Tytuł :
DNMT1 promotes cell proliferation via methylating hMLH1 and hMSH2 promoters in EGFR-mutated non-small cell lung cancer.
Autorzy :
Wu XY; Department of Respiration, Jinhua Guangfu Cancer Hospital, No. 1296, North Huancheng Rd, Wucheng District, Jinhua, Zhejiang 321000, China.
Chen HC; Department of Respiration, Jinhua Guangfu Cancer Hospital, No. 1296, North Huancheng Rd, Wucheng District, Jinhua, Zhejiang 321000, China.
Li WW; Department of Respiration, Jinhua Guangfu Cancer Hospital, No. 1296, North Huancheng Rd, Wucheng District, Jinhua, Zhejiang 321000, China.
Yan JD; Department of Respiration, Jinhua Guangfu Cancer Hospital, No. 1296, North Huancheng Rd, Wucheng District, Jinhua, Zhejiang 321000, China.
Lv RY; Department of Respiration, Jinhua Guangfu Cancer Hospital, No. 1296, North Huancheng Rd, Wucheng District, Jinhua, Zhejiang 321000, China.
Pokaż więcej
Źródło :
Journal of biochemistry [J Biochem] 2020 Aug 01; Vol. 168 (2), pp. 151-157.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Methylation*
Promoter Regions, Genetic*
Carcinoma, Non-Small-Cell Lung/*genetics
DNA (Cytosine-5-)-Methyltransferase 1/*metabolism
Lung Neoplasms/*genetics
MutL Protein Homolog 1/*genetics
MutS Homolog 2 Protein/*genetics
A549 Cells ; Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Proliferation ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Female ; Humans ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Male ; Middle Aged ; MutL Protein Homolog 1/metabolism ; MutS Homolog 2 Protein/metabolism ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Prediction Model for Gastric Cancer With DNA Mismatch Repair Deficiency.
Autorzy :
Suzuki O; Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan; .
Yamaguchi T; Department of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan.; Department of Clinical Genetics, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan.
Fukuchi M; Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
Mochiki E; Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
Arai T; Department of Pathology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan.
Akagi K; Division of Molecular Diagnosis and Cancer Prevention, Saitama Cancer Center, Saitama, Japan.
Ishida H; Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
Pokaż więcej
Źródło :
Anticancer research [Anticancer Res] 2021 Feb; Vol. 41 (2), pp. 975-982.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Mismatch Repair*
DNA-Binding Proteins/*deficiency
Mismatch Repair Endonuclease PMS2/*deficiency
MutL Protein Homolog 1/*deficiency
Stomach Neoplasms/*pathology
Adult ; Aged ; Aged, 80 and over ; Area Under Curve ; Biomarkers, Tumor/metabolism ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Grading ; Neoplasm Invasiveness ; Sex Characteristics ; Stomach Neoplasms/metabolism ; Tumor Burden ; Young Adult
Czasopismo naukowe
Tytuł :
Cytological Monitoring of Meiotic Crossovers in Spermatocytes and Oocytes.
Autorzy :
Yun Y; Howard Hughes Medical Institute, Department of Microbiology and Molecular Genetics, Davis, University of California, Davis, CA, USA.
Ito M; Howard Hughes Medical Institute, Department of Microbiology and Molecular Genetics, Davis, University of California, Davis, CA, USA.
Sandhu S; Howard Hughes Medical Institute, Department of Microbiology and Molecular Genetics, Davis, University of California, Davis, CA, USA.
Hunter N; Howard Hughes Medical Institute, Department of Microbiology and Molecular Genetics, Davis, University of California, Davis, CA, USA. .
Pokaż więcej
Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2153, pp. 267-286.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Crossing Over, Genetic*
MutL Protein Homolog 1/*metabolism
Oocytes/*cytology
Spermatocytes/*cytology
Aneuploidy ; Animals ; Cells, Cultured ; Chromosomes, Mammalian/metabolism ; Female ; Immunohistochemistry ; Male ; Mice ; Oocytes/metabolism ; Pachytene Stage ; Spermatocytes/metabolism
Czasopismo naukowe
Tytuł :
Human MutLγ, the MLH1-MLH3 heterodimer, is an endonuclease that promotes DNA expansion.
Autorzy :
Kadyrova LY; Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, IL 62901.
Gujar V; Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, IL 62901.
Burdett V; Department of Biochemistry, Duke University Medical Center, Durham, NC 27710.
Modrich PL; Department of Biochemistry, Duke University Medical Center, Durham, NC 27710; .; Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710.
Kadyrov FA; Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, IL 62901; .
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Feb 18; Vol. 117 (7), pp. 3535-3542. Date of Electronic Publication: 2020 Feb 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
MutL Protein Homolog 1/*metabolism
MutL Proteins/*metabolism
DNA Mismatch Repair ; Dimerization ; Endonucleases/chemistry ; Endonucleases/genetics ; Endonucleases/metabolism ; Humans ; MutL Protein Homolog 1/chemistry ; MutL Protein Homolog 1/genetics ; MutL Proteins/chemistry ; MutL Proteins/genetics ; Trinucleotide Repeat Expansion
Czasopismo naukowe
Tytuł :
Extracellular vesicles transmitted miR-31-5p promotes sorafenib resistance by targeting MLH1 in renal cell carcinoma.
Autorzy :
He J; Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.; Department of Head and Neck Cancer, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
He J; State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Min L; Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
He Y; Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Guan H; Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Wang J; Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Peng X; Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Pokaż więcej
Źródło :
International journal of cancer [Int J Cancer] 2020 Feb 15; Vol. 146 (4), pp. 1052-1063. Date of Electronic Publication: 2019 Jul 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Renal Cell/*drug therapy
Extracellular Vesicles/*metabolism
MicroRNAs/*metabolism
MutL Protein Homolog 1/*metabolism
Sorafenib/*pharmacology
Animals ; Antineoplastic Agents/pharmacology ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/metabolism ; Extracellular Vesicles/genetics ; Humans ; Kidney Neoplasms/drug therapy ; Kidney Neoplasms/genetics ; Kidney Neoplasms/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; MutL Protein Homolog 1/biosynthesis ; MutL Protein Homolog 1/genetics ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Correlation of MLH1 polymorphisms, survival statistics, in silico assessment and gene downregulation with clinical outcomes among breast cancer cases.
Autorzy :
Malik SS; Fatima Jinnah Women University, The Mall Rawalpindi, Rawalpindi, Pakistan. .; Armed Forces Institute of Pathology, Rawalpindi, Pakistan. .
Zia A; National Centre for Bioinformatics, Quaid-i-Azam University, Islamabad, Pakistan.
Mubarik S; Department of Epidemiology and Biostatistics, School of Health Sciences, Wuhan University, Wuhan, China.
Masood N; Fatima Jinnah Women University, The Mall Rawalpindi, Rawalpindi, Pakistan.
Rashid S; National Centre for Bioinformatics, Quaid-i-Azam University, Islamabad, Pakistan.
Sherrard A; Department of Cellular and Molecular Medicine, School of Life Sciences, Bristol University, Bristol, UK.
Khan MB; Armed Forces Institute of Pathology, Rawalpindi, Pakistan.
Khadim MT; Armed Forces Institute of Pathology, Rawalpindi, Pakistan.
Pokaż więcej
Źródło :
Molecular biology reports [Mol Biol Rep] 2020 Jan; Vol. 47 (1), pp. 683-692. Date of Electronic Publication: 2019 Nov 08.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms*/chemistry
Breast Neoplasms*/genetics
Breast Neoplasms*/mortality
MutL Protein Homolog 1*/analysis
MutL Protein Homolog 1*/chemistry
MutL Protein Homolog 1*/genetics
MutL Protein Homolog 1*/metabolism
Adult ; Breast/chemistry ; DNA Mutational Analysis ; Down-Regulation/genetics ; Female ; Humans ; Middle Aged ; Polymorphism, Single Nucleotide/genetics
Czasopismo naukowe
Tytuł :
Nucleus-specific linker histones Hho1 and Mlh1 form distinct protein interactions during growth, starvation and development in Tetrahymena thermophila.
Autorzy :
Nabeel-Shah S; Department of Chemistry and Biology, Ryerson University, 350 Victoria St., Toronto, M5B 2K3, Canada.; Donnelly Centre, University of Toronto, Toronto, M5S 3E1, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, M5S 1A8, Canada.
Ashraf K; Department of Biology, York University, 4700 Keele St., Toronto, M3J 1P3, Canada.
Saettone A; Department of Chemistry and Biology, Ryerson University, 350 Victoria St., Toronto, M5B 2K3, Canada.
Garg J; Department of Biology, York University, 4700 Keele St., Toronto, M3J 1P3, Canada.
Derynck J; Department of Chemistry and Biology, Ryerson University, 350 Victoria St., Toronto, M5B 2K3, Canada.
Lambert JP; Department of Molecular Medicine and Cancer Research Centre, Université Laval, Quebec, Canada.; CHU de Québec Research Center, CHUL, 2705 Laurier Boulevard, Quebec, G1V 4G2, Canada.
Pearlman RE; Department of Biology, York University, 4700 Keele St., Toronto, M3J 1P3, Canada. .
Fillingham J; Department of Chemistry and Biology, Ryerson University, 350 Victoria St., Toronto, M5B 2K3, Canada. .
Pokaż więcej
Źródło :
Scientific reports [Sci Rep] 2020 Jan 13; Vol. 10 (1), pp. 168. Date of Electronic Publication: 2020 Jan 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Developmental*
High Mobility Group Proteins/*metabolism
Histones/*metabolism
MutL Protein Homolog 1/*metabolism
Proteome/*analysis
Protozoan Proteins/*metabolism
Tetrahymena thermophila/*growth & development
Amino Acid Sequence ; Animals ; Cell Nucleus/genetics ; Cell Nucleus/metabolism ; Chromatin/genetics ; Chromatin/metabolism ; Gene Expression Regulation ; High Mobility Group Proteins/genetics ; MutL Protein Homolog 1/genetics ; Protein Interaction Domains and Motifs ; Protozoan Proteins/genetics ; Starvation ; Tetrahymena thermophila/genetics ; Tetrahymena thermophila/metabolism
Czasopismo naukowe
Tytuł :
MLH1 deficiency leads to deregulated mitochondrial metabolism.
Autorzy :
Rashid S; Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Freitas MO; Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Cucchi D; Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Bridge G; Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Yao Z; Department of Cell and Developmental Biology, Consortium for Mitochondrial Research, University College London, London, WC1E 6BT, UK.
Gay L; Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Williams M; Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Wang J; Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Suraweera N; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London, E1 2AT, UK.
Silver A; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London, E1 2AT, UK.
McDonald SAC; Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Chelala C; Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Szabadkai G; Department of Cell and Developmental Biology, Consortium for Mitochondrial Research, University College London, London, WC1E 6BT, UK.; Department of Biomedical Sciences, University of Padua, Padua, 35131, Italy.; The Francis Crick Institute, London, NW1 1AT, UK.
Martin SA; Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK. .
Pokaż więcej
Źródło :
Cell death & disease [Cell Death Dis] 2019 Oct 22; Vol. 10 (11), pp. 795. Date of Electronic Publication: 2019 Oct 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mitochondria/*metabolism
MutL Protein Homolog 1/*deficiency
Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; DNA Mismatch Repair ; Electron Transport Complex I/antagonists & inhibitors ; Electron Transport Complex I/genetics ; Electron Transport Complex I/metabolism ; Endometrial Neoplasms/genetics ; Endometrial Neoplasms/metabolism ; Endometrial Neoplasms/pathology ; Female ; HCT116 Cells ; HT29 Cells ; Humans ; Male ; Mitochondria/genetics ; MutL Protein Homolog 1/genetics ; MutL Protein Homolog 1/metabolism ; Mutation ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/metabolism ; Ovarian Neoplasms/pathology ; Rotenone/pharmacology ; Transfection
Czasopismo naukowe
Tytuł :
Highly sensitive MLH1 methylation analysis in blood identifies a cancer patient with low-level mosaic MLH1 epimutation.
Autorzy :
Dámaso E; Hereditary Cancer Program, Catalan Institute of Oncology, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), ONCOBELL Program, Av. Gran Via de l'Hospitalet, 199-203, 08908 L' Hospitalet de Llobregat, Barcelona, Spain.
Canet-Hermida J; Hereditary Cancer Program, Catalan Institute of Oncology, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), ONCOBELL Program, Av. Gran Via de l'Hospitalet, 199-203, 08908 L' Hospitalet de Llobregat, Barcelona, Spain.
Vargas-Parra G; Hereditary Cancer Program, Catalan Institute of Oncology, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), ONCOBELL Program, Av. Gran Via de l'Hospitalet, 199-203, 08908 L' Hospitalet de Llobregat, Barcelona, Spain.; Department of General and Digestive Surgery, Dr Josep Trueta University Hospital, Girona, Spain.
Velasco À; Department of General and Digestive Surgery, Dr Josep Trueta University Hospital, Girona, Spain.; Hereditary Cancer Program, Catalan Institute of Oncology, Institut d'Investigació Biomèdica de Girona (IDIBGI), Girona, Spain.
Marín F; Hereditary Cancer Program, Catalan Institute of Oncology, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), ONCOBELL Program, Av. Gran Via de l'Hospitalet, 199-203, 08908 L' Hospitalet de Llobregat, Barcelona, Spain.; Department of General and Digestive Surgery, Dr Josep Trueta University Hospital, Girona, Spain.
Darder E; Hereditary Cancer Program, Catalan Institute of Oncology, Institut d'Investigació Biomèdica de Girona (IDIBGI), Girona, Spain.
Del Valle J; Hereditary Cancer Program, Catalan Institute of Oncology, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), ONCOBELL Program, Av. Gran Via de l'Hospitalet, 199-203, 08908 L' Hospitalet de Llobregat, Barcelona, Spain.; Department of General and Digestive Surgery, Dr Josep Trueta University Hospital, Girona, Spain.
Fernández A; Hereditary Cancer Program, Catalan Institute of Oncology, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), ONCOBELL Program, Av. Gran Via de l'Hospitalet, 199-203, 08908 L' Hospitalet de Llobregat, Barcelona, Spain.
Izquierdo À; Hereditary Cancer Program, Catalan Institute of Oncology, Institut d'Investigació Biomèdica de Girona (IDIBGI), Girona, Spain.
Mateu G; Pathology Department, Dr Josep Trueta University Hospital, Girona, Spain.
Oliveras G; Pathology Department, Dr Josep Trueta University Hospital, Girona, Spain.
Escribano C; Pathology Department, Clínica Girona, Girona, Spain.
Piñol V; Department of Gastroenterology, Dr Josep Trueta University Hospital, Girona, Spain.
Uchima HI; Department of Gastroenterology, Dr Josep Trueta University Hospital, Girona, Spain.
Soto JL; Hereditary Cancer Program Valencian Region, Molecular Genetics Laboratory, Elche University Hospital, Elche, Alicante, Spain.
Hitchins M; Department of Biomedical Sciences, Cedars-Sinai Medical Center, CA, Los Angeles, USA.
Farrés R; Department of General and Digestive Surgery, Dr Josep Trueta University Hospital, Girona, Spain.
Lázaro C; Hereditary Cancer Program, Catalan Institute of Oncology, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), ONCOBELL Program, Av. Gran Via de l'Hospitalet, 199-203, 08908 L' Hospitalet de Llobregat, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.
Queralt B; Department of Medical Oncology, Catalan Institute of Oncology, Girona, Spain.
Brunet J; Hereditary Cancer Program, Catalan Institute of Oncology, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), ONCOBELL Program, Av. Gran Via de l'Hospitalet, 199-203, 08908 L' Hospitalet de Llobregat, Barcelona, Spain.; Hereditary Cancer Program, Catalan Institute of Oncology, Institut d'Investigació Biomèdica de Girona (IDIBGI), Girona, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.; Department of Medical Sciences Department, School of Medicine, University of Girona, Girona, Spain.
Capellá G; Hereditary Cancer Program, Catalan Institute of Oncology, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), ONCOBELL Program, Av. Gran Via de l'Hospitalet, 199-203, 08908 L' Hospitalet de Llobregat, Barcelona, Spain. .; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain. .
Pineda M; Hereditary Cancer Program, Catalan Institute of Oncology, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), ONCOBELL Program, Av. Gran Via de l'Hospitalet, 199-203, 08908 L' Hospitalet de Llobregat, Barcelona, Spain. .; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain. .
Pokaż więcej
Źródło :
Clinical epigenetics [Clin Epigenetics] 2019 Nov 28; Vol. 11 (1), pp. 171. Date of Electronic Publication: 2019 Nov 28.
Typ publikacji :
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Methylation*
Mutation*
Colorectal Neoplasms/*genetics
Genetic Testing/*methods
MutL Protein Homolog 1/*genetics
Adult ; Colorectal Neoplasms/blood ; DNA/blood ; Female ; Humans ; Male ; Middle Aged ; Mosaicism ; MutL Protein Homolog 1/blood ; Promoter Regions, Genetic ; Young Adult
Czasopismo naukowe
Tytuł :
Relationship between MLH1, PMS2, MSH2 and MSH6 gene-specific alterations and tumor mutational burden in 1057 microsatellite instability-high solid tumors.
Autorzy :
Salem ME; Levine Cancer Institute, Atrium Health, Charlotte, North Carolina, USA.
Bodor JN; Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.
Puccini A; Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.; Medical Oncology Unit 1, University of Genoa, Ospedale Policlinico San Martino IRCCS, Genoa, Italy.
Xiu J; Caris Life Sciences, Scottsdale, Arizona, USA.
Goldberg RM; West Virginia University Cancer Institute, Morgantown, West Virginia, USA.
Grothey A; West Cancer Center, Germantown, Tennessee, USA.
Korn WM; Caris Life Sciences, Scottsdale, Arizona, USA.; Division of Hematology/Oncology, University of California San Francisco, San Francisco, California, USA.
Shields AF; Karmanos Cancer Institute, Detroit, Michigan, USA.
Worrilow WM; Levine Cancer Institute, Atrium Health, Charlotte, North Carolina, USA.
Kim ES; Levine Cancer Institute, Atrium Health, Charlotte, North Carolina, USA.
Lenz HJ; Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
Marshall JL; Georgetown Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, USA.
Hall MJ; Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.
Pokaż więcej
Źródło :
International journal of cancer [Int J Cancer] 2020 Nov 15; Vol. 147 (10), pp. 2948-2956. Date of Electronic Publication: 2020 Jun 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Microsatellite Instability*
DNA-Binding Proteins/*metabolism
Mismatch Repair Endonuclease PMS2/*metabolism
MutL Protein Homolog 1/*metabolism
MutS Homolog 2 Protein/*metabolism
Neoplasms/*genetics
Aged ; Female ; Gene Expression Regulation, Neoplastic ; High-Throughput Nucleotide Sequencing ; Humans ; Male ; Middle Aged ; Mutation, Missense ; Retrospective Studies ; Sequence Analysis, DNA
Czasopismo naukowe
Tytuł :
Molecular tumor testing in patients with Lynch-like syndrome reveals a de novo mosaic variant of a mismatch repair gene transmitted to offspring.
Autorzy :
Guillerm E; Department of Genetics, Hôpital Universitaire Pitié Salpêtrière (Assistance Publique-Hôpitaux de Paris), Paris VI University, Paris, France. .; INSERM, UMRS 938-Centre de Recherche Saint-Antoine, Equipe 'Instabilité des Microsatellites et Cancers', Equipe labellisée par la Ligue Nationale contre le Cancer, Paris, France. .; France Université Pierre et Marie Curie, Paris, France. .
Svrcek M; INSERM, UMRS 938-Centre de Recherche Saint-Antoine, Equipe 'Instabilité des Microsatellites et Cancers', Equipe labellisée par la Ligue Nationale contre le Cancer, Paris, France.; France Université Pierre et Marie Curie, Paris, France.; Department of Pathology, Hôpital Saint Antoine (Assistance Publique-Hôpitaux de Paris), Paris VI University, Paris, France.
Bardier-Dupas A; Department of Pathology, Hôpital Universitaire Pitié Salpêtrière (Assistance Publique-Hôpitaux de Paris), Paris VI University, Paris, France.
Basset N; Department of Genetics, Hôpital Universitaire Pitié Salpêtrière (Assistance Publique-Hôpitaux de Paris), Paris VI University, Paris, France.; INSERM, UMRS 938-Centre de Recherche Saint-Antoine, Equipe 'Instabilité des Microsatellites et Cancers', Equipe labellisée par la Ligue Nationale contre le Cancer, Paris, France.; France Université Pierre et Marie Curie, Paris, France.
Coulet F; Department of Genetics, Hôpital Universitaire Pitié Salpêtrière (Assistance Publique-Hôpitaux de Paris), Paris VI University, Paris, France.; INSERM, UMRS 938-Centre de Recherche Saint-Antoine, Equipe 'Instabilité des Microsatellites et Cancers', Equipe labellisée par la Ligue Nationale contre le Cancer, Paris, France.; France Université Pierre et Marie Curie, Paris, France.
Colas C; Department of Genetics, Hôpital Universitaire Pitié Salpêtrière (Assistance Publique-Hôpitaux de Paris), Paris VI University, Paris, France.; INSERM, UMRS 938-Centre de Recherche Saint-Antoine, Equipe 'Instabilité des Microsatellites et Cancers', Equipe labellisée par la Ligue Nationale contre le Cancer, Paris, France.; France Université Pierre et Marie Curie, Paris, France.; Department of Genetics, Curie Institute, Paris, France.
Pokaż więcej
Źródło :
European journal of human genetics : EJHG [Eur J Hum Genet] 2020 Nov; Vol. 28 (11), pp. 1624-1628. Date of Electronic Publication: 2020 Jul 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Colorectal Neoplasms, Hereditary Nonpolyposis/*genetics
MutL Protein Homolog 1/*genetics
Colon/metabolism ; Colon/pathology ; Colorectal Neoplasms, Hereditary Nonpolyposis/pathology ; Female ; Humans ; Male ; Mosaicism ; Mutation ; Pedigree
Czasopismo naukowe
Tytuł :
MLH1 single-nucleotide variant in circulating tumor DNA predicts overall survival of patients with hepatocellular carcinoma.
Autorzy :
Kim SS; Department of Gastroenterology, Ajou University School of Medicine, Suwon, Republic of Korea.
Eun JW; Department of Gastroenterology, Ajou University School of Medicine, Suwon, Republic of Korea.
Choi JH; Department of Physiology, Ajou University School of Medicine, Suwon, Republic of Korea.
Woo HG; Department of Physiology, Ajou University School of Medicine, Suwon, Republic of Korea.
Cho HJ; Department of Gastroenterology, Ajou University School of Medicine, Suwon, Republic of Korea.
Ahn HR; Department of Biomedical Science, Ajou University Graduate School of Medicine, Suwon, Republic of Korea.
Suh CW; Department of Biomedical Science, Ajou University Graduate School of Medicine, Suwon, Republic of Korea.
Baek GO; Department of Gastroenterology, Ajou University School of Medicine, Suwon, Republic of Korea.
Cho SW; Department of Gastroenterology, Ajou University School of Medicine, Suwon, Republic of Korea.
Cheong JY; Department of Gastroenterology, Ajou University School of Medicine, Suwon, Republic of Korea. .
Pokaż więcej
Źródło :
Scientific reports [Sci Rep] 2020 Oct 20; Vol. 10 (1), pp. 17862. Date of Electronic Publication: 2020 Oct 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Polymorphism, Single Nucleotide*
Carcinoma, Hepatocellular/*pathology
DNA, Neoplasm/*blood
Liver Neoplasms/*pathology
MutL Protein Homolog 1/*genetics
Aged ; Carcinoma, Hepatocellular/blood ; Carcinoma, Hepatocellular/genetics ; DNA, Neoplasm/genetics ; Female ; Humans ; Liver Neoplasms/blood ; Liver Neoplasms/genetics ; Male ; Middle Aged ; PTEN Phosphohydrolase/genetics ; Prognosis ; Survival Analysis ; beta Catenin/genetics
Czasopismo naukowe
Tytuł :
MLH1 focus mapping in the guinea fowl (Numida meleagris) give insights into the crossover landscapes in birds.
Autorzy :
Del Priore L; INBIOMED (CONICET-UBA), Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
Pigozzi MI; INBIOMED (CONICET-UBA), Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
Pokaż więcej
Źródło :
PloS one [PLoS One] 2020 Oct 05; Vol. 15 (10), pp. e0240245. Date of Electronic Publication: 2020 Oct 05 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
MutL Protein Homolog 1/*metabolism
Synaptonemal Complex/*metabolism
Animals ; Chickens ; Karyotype ; Oocytes ; Phylogeny
Czasopismo naukowe
Tytuł :
DNA damage signalling as an anti-cancer barrier in gastric intestinal metaplasia.
Autorzy :
Krishnan V; Cancer Science Institute of Singapore, National University of Singapore, Singapore.; Program in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore.
Lim DXE; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Hoang PM; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Srivastava S; Department of Pathology, National University of Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Matsuo J; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Huang KK; Program in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore.
Zhu F; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Ho KY; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Gastroenterology and Hepatology, National University Health System, Singapore.
So JBY; Department of Surgery, National University of Singapore, Singapore.; Singapore Gastric Cancer Consortium, Singapore.
Khor C; Department of Gastroenterology & Hepatology, Singapore General Hospital, Singapore.
Tsao S; Department of Gastroenterology and Hepatology, Tan Tock Seng Hospital, Singapore.
Teh M; Department of Pathology, National University of Singapore, Singapore.
Fock KM; Department of Gastroenterology, Changi General Hospital, Singapore.
Ang TL; Department of Gastroenterology, Changi General Hospital, Singapore.
Jeyasekharan AD; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Tan P; Program in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore.; Singapore Gastric Cancer Consortium, Singapore.
Yeoh KG; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore .; Department of Gastroenterology and Hepatology, National University Health System, Singapore.; Singapore Gastric Cancer Consortium, Singapore.
Ito Y; Cancer Science Institute of Singapore, National University of Singapore, Singapore .; Singapore Gastric Cancer Consortium, Singapore.
Pokaż więcej
Źródło :
Gut [Gut] 2020 Oct; Vol. 69 (10), pp. 1738-1749. Date of Electronic Publication: 2020 Jan 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Stomach Neoplasms*/genetics
Stomach Neoplasms*/pathology
Gastric Mucosa/*pathology
Histones/*genetics
Minichromosome Maintenance Complex Component 2/*genetics
MutL Protein Homolog 1/*genetics
Rad52 DNA Repair and Recombination Protein/*genetics
Werner Syndrome Helicase/*genetics
Biopsy/methods ; DNA Damage/genetics ; DNA Methylation ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Hyaluronan Receptors/analysis ; Male ; Metaplasia/genetics ; Metaplasia/pathology ; Middle Aged ; Mutation ; Protective Factors ; Signal Transduction
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies