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Tytuł:
Expression of epigenetic pathway related genes in association with PD-L1, ER/PgR and MLH1 in endometrial carcinoma.
Autorzy:
Saglam O; Department of Pathology, Moffitt Cancer Center, Tampa, FL, United States of America.
Cao B; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, FL, United States of America.
Wang X; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, FL, United States of America.
Toruner GA; Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX, United States of America.
Conejo-Garcia JR; Department of Immunology, Moffitt Cancer Center, Tampa, FL, United States of America.
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Źródło:
PloS one [PLoS One] 2022 Feb 28; Vol. 17 (2), pp. e0264014. Date of Electronic Publication: 2022 Feb 28 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Epigenesis, Genetic*
Gene Expression Regulation, Neoplastic*
B7-H1 Antigen/*biosynthesis
Endometrial Neoplasms/*metabolism
MutL Protein Homolog 1/*biosynthesis
Neoplasm Proteins/*biosynthesis
Receptors, Progesterone/*biosynthesis
Aged ; Endometrial Neoplasms/pathology ; Female ; Humans ; Middle Aged
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Haploinsufficiency by minute MutL homolog 1 promoter DNA methylation may represent unique phenotypes of microsatellite instability-gastric carcinogenesis.
Autorzy:
Harada H; Department of Upper-gastrointestinal Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Nie Y; Department of General, Pediatric and Hepatobiliary-Pancreatic Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Araki I; Department of Upper-gastrointestinal Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Soeno T; Department of Upper-gastrointestinal Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Chuman M; Department of Upper-gastrointestinal Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Washio M; Department of Upper-gastrointestinal Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Sakuraya M; Department of Upper-gastrointestinal Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Ushiku H; Department of Upper-gastrointestinal Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Niihara M; Department of Upper-gastrointestinal Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Hosoda K; Department of Upper-gastrointestinal Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Kumamoto Y; Department of General, Pediatric and Hepatobiliary-Pancreatic Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Naitoh T; Department of Lower Gastrointestinal Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Sangai T; Department of Breast and Thyroid Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Hiki N; Department of Upper-gastrointestinal Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Yamashita K; Department of Upper-gastrointestinal Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.; Division of Advanced Surgical Oncology, Department of Research and Development Center for New Medical Frontiers, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
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Źródło:
PloS one [PLoS One] 2021 Dec 22; Vol. 16 (12), pp. e0260303. Date of Electronic Publication: 2021 Dec 22 (Print Publication: 2021).
Typ publikacji:
Journal Article
MeSH Terms:
DNA Methylation*
Microsatellite Instability*
Epstein-Barr Virus Infections/*genetics
MutL Protein Homolog 1/*genetics
Neoplasms, Multiple Primary/*surgery
Stomach Neoplasms/*surgery
Age Factors ; Cell Line, Tumor ; DNA, Viral/genetics ; Female ; Gastrectomy ; Haploinsufficiency ; Herpesvirus 4, Human/genetics ; Humans ; Male ; Neoplasms, Multiple Primary/genetics ; Neoplasms, Multiple Primary/virology ; Phenotype ; Polymerase Chain Reaction ; Promoter Regions, Genetic ; Stomach Neoplasms/genetics ; Stomach Neoplasms/virology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
MLH1 focus mapping in the guinea fowl (Numida meleagris) give insights into the crossover landscapes in birds.
Autorzy:
Del Priore L; INBIOMED (CONICET-UBA), Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
Pigozzi MI; INBIOMED (CONICET-UBA), Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
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Źródło:
PloS one [PLoS One] 2020 Oct 05; Vol. 15 (10), pp. e0240245. Date of Electronic Publication: 2020 Oct 05 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
MutL Protein Homolog 1/*metabolism
Synaptonemal Complex/*metabolism
Animals ; Chickens ; Karyotype ; Oocytes ; Phylogeny
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Targeted sequencing of genes associated with the mismatch repair pathway in patients with endometrial cancer.
Autorzy:
Singh AK; Department of Medical Genetics, St. Olavs Hospital, Trondheim, Norway.; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, Trondheim, Norway.
Talseth-Palmer B; Department of Medical Genetics, St. Olavs Hospital, Trondheim, Norway.; School of Biomedical Science and Pharmacy, Faculty of Health and Medicine, University of Newcastle and Hunter Medical Research Institute, Newcastle, Australia.; Department of Research and Development, Møre og Romsdal Hospital Trust, Molde, Norway.
McPhillips M; NSW Health Pathology, Molecular Medicine, John Hunter Hospital, Newcastle, NSW, Australia.
Lavik LAS; Department of Medical Genetics, St. Olavs Hospital, Trondheim, Norway.
Xavier A; School of Biomedical Science and Pharmacy, Faculty of Health and Medicine, University of Newcastle and Hunter Medical Research Institute, Newcastle, Australia.
Drabløs F; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, Trondheim, Norway.
Sjursen W; Department of Medical Genetics, St. Olavs Hospital, Trondheim, Norway.; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, Trondheim, Norway.
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Źródło:
PloS one [PLoS One] 2020 Jul 07; Vol. 15 (7), pp. e0235613. Date of Electronic Publication: 2020 Jul 07 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA Mismatch Repair*
Endometrial Neoplasms/*pathology
Mismatch Repair Endonuclease PMS2/*genetics
MutL Protein Homolog 1/*genetics
MutS Homolog 2 Protein/*genetics
Colorectal Neoplasms, Hereditary Nonpolyposis/genetics ; Colorectal Neoplasms, Hereditary Nonpolyposis/pathology ; DNA Copy Number Variations ; DNA, Neoplasm/blood ; DNA, Neoplasm/chemistry ; DNA, Neoplasm/metabolism ; Endometrial Neoplasms/genetics ; Exons ; Female ; High-Throughput Nucleotide Sequencing ; Humans ; Introns ; Risk Factors ; Untranslated Regions/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Investigation on the hereditary basis of colorectal cancers in an African population with frequent early onset cases.
Autorzy:
Katsidzira L; Department of Medicine, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.; MRC/UCT Research Unit for Genomic and Precision Medicine, Division of Human Genetics, Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Vorster A; MRC/UCT Research Unit for Genomic and Precision Medicine, Division of Human Genetics, Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.; Central Analytical Facility (CAF), DNA Sequencing Unit, Stellenbosch University, Stellenbosch, South Africa.
Gangaidzo IT; Department of Medicine, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
Makunike-Mutasa R; Department of Histopathology, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
Govender D; Division of Anatomical Pathology, Faculty of Health Sciences, University of Cape Town, and National Health Laboratory Service Groote Schuur hospital, Cape Town, South Africa.
Rusakaniko S; Department of Community Medicine, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
Thomson S; Division of Gastroenterology, Department of Medicine, University of Cape Town, Cape Town, Groote Schuur Hospital, Cape Town, South Africa.
Matenga JA; Department of Medicine, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
Ramesar R; MRC/UCT Research Unit for Genomic and Precision Medicine, Division of Human Genetics, Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
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Źródło:
PloS one [PLoS One] 2019 Oct 24; Vol. 14 (10), pp. e0224023. Date of Electronic Publication: 2019 Oct 24 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genetic Predisposition to Disease*
Germ-Line Mutation*
Black People/*genetics
Colorectal Neoplasms/*genetics
Epithelial Cell Adhesion Molecule/*genetics
MutL Protein Homolog 1/*genetics
MutS Homolog 2 Protein/*genetics
Adult ; Age of Onset ; Colorectal Neoplasms/epidemiology ; Cross-Sectional Studies ; Female ; Humans ; Incidence ; Male ; Microsatellite Instability ; Middle Aged ; Prognosis ; Prospective Studies ; Zimbabwe/epidemiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Downregulation of SPTAN1 is related to MLH1 deficiency and metastasis in colorectal cancer.
Autorzy:
Ackermann A; Medical Clinic I, Biomedical Research Laboratory, University Clinic Frankfurt, Frankfurt am Main, Germany.
Schrecker C; Medical Clinic I, Biomedical Research Laboratory, University Clinic Frankfurt, Frankfurt am Main, Germany.
Bon D; Institute for Biostatistics and Mathematical Modelling, Goethe University, Frankfurt am Main, Germany.
Friedrichs N; Institute of Pathology, University of Cologne Medical School, Cologne, Germany.
Bankov K; Dr. Senckenberg Institute of Pathology, University Hospital Frankfurt, Frankfurt am Main, Germany.
Wild P; Dr. Senckenberg Institute of Pathology, University Hospital Frankfurt, Frankfurt am Main, Germany.
Plotz G; Medical Clinic I, Biomedical Research Laboratory, University Clinic Frankfurt, Frankfurt am Main, Germany.
Zeuzem S; Medical Clinic I, Biomedical Research Laboratory, University Clinic Frankfurt, Frankfurt am Main, Germany.
Herrmann E; Institute for Biostatistics and Mathematical Modelling, Goethe University, Frankfurt am Main, Germany.
Hansmann ML; Dr. Senckenberg Institute of Pathology, University Hospital Frankfurt, Frankfurt am Main, Germany.
Brieger A; Medical Clinic I, Biomedical Research Laboratory, University Clinic Frankfurt, Frankfurt am Main, Germany.
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Źródło:
PloS one [PLoS One] 2019 Mar 11; Vol. 14 (3), pp. e0213411. Date of Electronic Publication: 2019 Mar 11 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Carrier Proteins/*metabolism
Colorectal Neoplasms/*metabolism
Colorectal Neoplasms/*pathology
Microfilament Proteins/*metabolism
MutL Protein Homolog 1/*deficiency
Aged ; Aged, 80 and over ; Caco-2 Cells ; Carrier Proteins/antagonists & inhibitors ; Carrier Proteins/genetics ; Cell Adhesion ; Cell Line, Tumor ; Cell Movement ; Cell Survival ; Cohort Studies ; Colorectal Neoplasms/genetics ; Disease Progression ; Down-Regulation ; Female ; Gene Knockdown Techniques ; Humans ; Immunohistochemistry ; Male ; Microfilament Proteins/antagonists & inhibitors ; Microfilament Proteins/genetics ; Middle Aged ; Neoplasm Metastasis/genetics ; Neoplasm Metastasis/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Systematic immunohistochemical screening for mismatch repair and ERCC1 gene expression from colorectal cancers in China: Clinicopathological characteristics and effects on survival.
Autorzy:
Li P; Department of Hematology and Oncology, Medizinische Klinik und Poliklinik IV, Ludwig Maximilians University, Munich, Germany.
Xiao Z; Department of Colorectal Surgery, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, China.
Braciak TA; Department of Hematology and Oncology, Medizinische Klinik und Poliklinik IV, Ludwig Maximilians University, Munich, Germany.
Ou Q; Department of Colorectal Surgery, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, China.
Chen G; Department of Colorectal Surgery, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, China.
Oduncu FS; Department of Hematology and Oncology, Medizinische Klinik und Poliklinik IV, Ludwig Maximilians University, Munich, Germany.
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Źródło:
PloS one [PLoS One] 2017 Aug 02; Vol. 12 (8), pp. e0181615. Date of Electronic Publication: 2017 Aug 02 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
Gene Expression*
Colorectal Neoplasms/*pathology
DNA-Binding Proteins/*metabolism
Endonucleases/*metabolism
Mismatch Repair Endonuclease PMS2/*metabolism
MutL Protein Homolog 1/*metabolism
MutS Homolog 2 Protein/*metabolism
Adult ; Aged ; Aged, 80 and over ; China ; Colorectal Neoplasms/metabolism ; DNA Mismatch Repair ; Female ; Humans ; Male ; Middle Aged ; Prognosis ; Survival Analysis ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Meiotic Recombination Analyses in Pigs Carrying Different Balanced Structural Chromosomal Rearrangements.
Autorzy:
Mary N; INRA, UMR1388 Génétique, Physiologie et Systèmes d'Elevage, Castanet-Tolosan, France.; Université de Toulouse INPT ENSAT, UMR1388 Génétique, Physiologie et Systèmes d'Elevage, Castanet-Tolosan, France.; Université de Toulouse INPT ENVT, UMR1388 Génétique, Physiologie et Systèmes d'Elevage, Toulouse, France.
Barasc H; Université de Toulouse INPT ENVT, UMR1388 Génétique, Physiologie et Systèmes d'Elevage, Toulouse, France.; Université de Toulouse INPT ENSAT, UMR1388 Génétique, Physiologie et Systèmes d'Elevage, Castanet-Tolosan, France.; INRA, UMR1388 Génétique, Physiologie et Systèmes d'Elevage, Castanet-Tolosan, France.
Ferchaud S; UE1372 GenESI Génétique, Expérimentation et Système Innovants, Surgères, France.
Priet A; UE1372 GenESI Génétique, Expérimentation et Système Innovants, Surgères, France.
Calgaro A; Université de Toulouse INPT ENVT, UMR1388 Génétique, Physiologie et Systèmes d'Elevage, Toulouse, France.; Université de Toulouse INPT ENSAT, UMR1388 Génétique, Physiologie et Systèmes d'Elevage, Castanet-Tolosan, France.; INRA, UMR1388 Génétique, Physiologie et Systèmes d'Elevage, Castanet-Tolosan, France.
Loustau-Dudez AM; INRA, UMR1388 Génétique, Physiologie et Systèmes d'Elevage, Castanet-Tolosan, France.; Université de Toulouse INPT ENSAT, UMR1388 Génétique, Physiologie et Systèmes d'Elevage, Castanet-Tolosan, France.; Université de Toulouse INPT ENVT, UMR1388 Génétique, Physiologie et Systèmes d'Elevage, Toulouse, France.
Bonnet N; Université de Toulouse INPT ENVT, UMR1388 Génétique, Physiologie et Systèmes d'Elevage, Toulouse, France.; Université de Toulouse INPT ENSAT, UMR1388 Génétique, Physiologie et Systèmes d'Elevage, Castanet-Tolosan, France.; INRA, UMR1388 Génétique, Physiologie et Systèmes d'Elevage, Castanet-Tolosan, France.
Yerle M; INRA, UMR1388 Génétique, Physiologie et Systèmes d'Elevage, Castanet-Tolosan, France.; Université de Toulouse INPT ENSAT, UMR1388 Génétique, Physiologie et Systèmes d'Elevage, Castanet-Tolosan, France.; Université de Toulouse INPT ENVT, UMR1388 Génétique, Physiologie et Systèmes d'Elevage, Toulouse, France.
Ducos A; Université de Toulouse INPT ENVT, UMR1388 Génétique, Physiologie et Systèmes d'Elevage, Toulouse, France.; Université de Toulouse INPT ENSAT, UMR1388 Génétique, Physiologie et Systèmes d'Elevage, Castanet-Tolosan, France.; INRA, UMR1388 Génétique, Physiologie et Systèmes d'Elevage, Castanet-Tolosan, France.
Pinton A; INRA, UMR1388 Génétique, Physiologie et Systèmes d'Elevage, Castanet-Tolosan, France.; Université de Toulouse INPT ENSAT, UMR1388 Génétique, Physiologie et Systèmes d'Elevage, Castanet-Tolosan, France.; Université de Toulouse INPT ENVT, UMR1388 Génétique, Physiologie et Systèmes d'Elevage, Toulouse, France.
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Źródło:
PloS one [PLoS One] 2016 Apr 28; Vol. 11 (4), pp. e0154635. Date of Electronic Publication: 2016 Apr 28 (Print Publication: 2016).
Typ publikacji:
Journal Article
MeSH Terms:
Chromosome Inversion/*genetics
Chromosome Inversion/*veterinary
Chromosome Pairing/*physiology
Meiosis/*genetics
MutL Protein Homolog 1/*genetics
Sus scrofa/*genetics
Translocation, Genetic/*genetics
Animals ; Crossing Over, Genetic/genetics ; DNA Breaks, Double-Stranded ; DNA Repair/genetics ; In Situ Hybridization, Fluorescence ; Male ; Sister Chromatid Exchange/genetics ; Swine
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
High concordance rate of capillary electrophoresis workflow for microsatellite instability analysis and mismatch repair (MMR) immunostaining in colorectal carcinoma.
Autorzy:
Huang W; Department of Pathology, Molecular Diagnosis Laboratory, National Cheng Kung University Hospital, Tainan, Taiwan.; Molecular Medicine Core Laboratory, Research Center of Clinical Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.; Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Ho CL; Department of Pathology, Molecular Diagnosis Laboratory, National Cheng Kung University Hospital, Tainan, Taiwan.; Molecular Medicine Core Laboratory, Research Center of Clinical Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.; Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Lee CT; Department of Pathology, Molecular Diagnosis Laboratory, National Cheng Kung University Hospital, Tainan, Taiwan.; Molecular Medicine Core Laboratory, Research Center of Clinical Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.; Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Chen WL; Department of Pathology, Molecular Diagnosis Laboratory, National Cheng Kung University Hospital, Tainan, Taiwan.; Molecular Medicine Core Laboratory, Research Center of Clinical Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.
Yang SC; Department of Pathology, Molecular Diagnosis Laboratory, National Cheng Kung University Hospital, Tainan, Taiwan.; Molecular Medicine Core Laboratory, Research Center of Clinical Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.
Chow NH; Department of Pathology, Molecular Diagnosis Laboratory, National Cheng Kung University Hospital, Tainan, Taiwan.; Molecular Medicine Core Laboratory, Research Center of Clinical Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.; Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Chen YL; Department of Pathology, Molecular Diagnosis Laboratory, National Cheng Kung University Hospital, Tainan, Taiwan.; Molecular Medicine Core Laboratory, Research Center of Clinical Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.; Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
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Źródło:
PloS one [PLoS One] 2023 Apr 25; Vol. 18 (4), pp. e0284227. Date of Electronic Publication: 2023 Apr 25 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Microsatellite Instability*
Colorectal Neoplasms*/diagnosis
Colorectal Neoplasms*/genetics
Colorectal Neoplasms*/pathology
Humans ; DNA Mismatch Repair/genetics ; Workflow ; Microsatellite Repeats/genetics ; DNA-Binding Proteins/genetics ; Electrophoresis, Capillary ; MutL Protein Homolog 1/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Functional characterization of MLH1 missense variants unveils mechanisms of pathogenicity and clarifies role in cancer.
Autorzy:
Mahdouani M; Laboratory of Human Cytogenetics, Molecular Genetics and Reproductive Biology, Farhat Hached University Hospital, Sousse, Tunisia.; Higher Institute of Biotechnology of Monastir, University of Monastir, Monastir, Tunisia.
Ben Ahmed S; Department of Oncology, Farhat Hached University Hospital, Sousse, Tunisia.; Faculty of Medicine Ibn El Jazzar of Sousse, University of Sousse, Sousse, Tunisia.
Hmila F; Faculty of Medicine Ibn El Jazzar of Sousse, University of Sousse, Sousse, Tunisia.; Department of General and Digestive Surgery, Farhat Hached University Hospital, Sousse, Tunisia.
Rais H; Medical Service, Salah Azaiez Institute, Tunis, Tunisia.
Ben Sghaier R; Laboratory of Human Cytogenetics, Molecular Genetics and Reproductive Biology, Farhat Hached University Hospital, Sousse, Tunisia.; Higher Institute of Biotechnology of Monastir, University of Monastir, Monastir, Tunisia.
Saad H; Laboratory of Human Cytogenetics, Molecular Genetics and Reproductive Biology, Farhat Hached University Hospital, Sousse, Tunisia.; Higher Institute of Biotechnology of Monastir, University of Monastir, Monastir, Tunisia.
Ben Said M; Laboratory of Molecular and Cellular Screening Processes, Centre of Biotechnology of Sfax, Sfax, Tunisia.
Masmoudi S; Laboratory of Molecular and Cellular Screening Processes, Centre of Biotechnology of Sfax, Sfax, Tunisia.
Hmida D; Laboratory of Human Cytogenetics, Molecular Genetics and Reproductive Biology, Farhat Hached University Hospital, Sousse, Tunisia.; Faculty of Medicine Ibn El Jazzar of Sousse, University of Sousse, Sousse, Tunisia.
Brieger A; Biomedical Research Laboratory, Department of Internal Medicine 1, University Hospital, Goethe University, Frankfurt am Main, Germany.
Zeuzem S; Biomedical Research Laboratory, Department of Internal Medicine 1, University Hospital, Goethe University, Frankfurt am Main, Germany.
Saad A; Laboratory of Human Cytogenetics, Molecular Genetics and Reproductive Biology, Farhat Hached University Hospital, Sousse, Tunisia.; Faculty of Medicine Ibn El Jazzar of Sousse, University of Sousse, Sousse, Tunisia.
Gribaa M; Laboratory of Human Cytogenetics, Molecular Genetics and Reproductive Biology, Farhat Hached University Hospital, Sousse, Tunisia.; Faculty of Medicine Ibn El Jazzar of Sousse, University of Sousse, Sousse, Tunisia.
Plotz G; Biomedical Research Laboratory, Department of Internal Medicine 1, University Hospital, Goethe University, Frankfurt am Main, Germany.
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Źródło:
PloS one [PLoS One] 2022 Dec 01; Vol. 17 (12), pp. e0278283. Date of Electronic Publication: 2022 Dec 01 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mutation, Missense*
Colorectal Neoplasms, Hereditary Nonpolyposis*/genetics
Humans ; Virulence ; DNA Mismatch Repair ; Germ-Line Mutation ; MutL Protein Homolog 1/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Genomic landscape of pathogenic mutation of APC, KRAS, TP53, PIK3CA, and MLH1 in Indonesian colorectal cancer.
Autorzy:
Marbun VMG; Department of General Surgery, Digestive Division, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.
Erlina L; Department of Medical Chemistry, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.
Lalisang TJM; Department of General Surgery, Digestive Division, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.
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Źródło:
PloS one [PLoS One] 2022 Jun 16; Vol. 17 (6), pp. e0267090. Date of Electronic Publication: 2022 Jun 16 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Colorectal Neoplasms*/pathology
Proto-Oncogene Proteins p21(ras)*/genetics
Class I Phosphatidylinositol 3-Kinases/genetics ; Genomics ; Humans ; Indonesia ; MutL Protein Homolog 1/genetics ; Mutation ; Tumor Suppressor Protein p53/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Targeting mitochondrial DNA polymerase gamma for selective inhibition of MLH1 deficient colon cancer growth.
Autorzy:
Somuncu B; Department of Medical Biotechnology, Institute of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.
Ekmekcioglu A; Department of Medical Biotechnology, Institute of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.
Antmen FM; Department of Medical Biotechnology, Institute of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.
Ertuzun T; Department of Medical Biotechnology, Institute of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.
Deniz E; Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.
Keskin N; Molecular Biology, Genetics and Bioengineering Program, Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul, Turkey.
Park J; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, United States of America.
Yazici IE; Department of Medical Biotechnology, Institute of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.
Simsek B; Molecular Biology, Genetics and Bioengineering Program, Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul, Turkey.
Erman B; Molecular Biology, Genetics and Bioengineering Program, Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul, Turkey.; Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Bogazici University, Istanbul, Turkey.
Yin W; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, United States of America.
Erman B; Department of Chemical and Biological Engineering, Koc University, Istanbul, Turkey.
Muftuoglu M; Department of Medical Biotechnology, Institute of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.; Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.
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Źródło:
PloS one [PLoS One] 2022 Jun 03; Vol. 17 (6), pp. e0268391. Date of Electronic Publication: 2022 Jun 03 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents*/therapeutic use
Colonic Neoplasms*/drug therapy
Colonic Neoplasms*/genetics
Colonic Neoplasms*/pathology
Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; DNA Methylation ; DNA Mismatch Repair ; DNA Polymerase gamma/genetics ; DNA Polymerase gamma/metabolism ; DNA, Mitochondrial/metabolism ; Female ; Humans ; Mitochondria/metabolism ; MutL Protein Homolog 1/metabolism ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
DACH1 mutation frequency in endometrial cancer is associated with high tumor mutation burden.
Autorzy:
Riggs MJ; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Kentucky, Lexington, Kentucky, United States of America.
Lin N; College of Pharmacy, University of Kentucky, Lexington, Kentucky, United States of America.
Wang C; Department of Biostatistics, College of Public Health, University of Kentucky, Lexington, Kentucky, United States of America.; Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America.
Piecoro DW; Division of Pathology, Department of Pathology and Laboratory Medicine, University of Kentucky, Lexington, Kentucky, United States of America.
Miller RW; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Kentucky, Lexington, Kentucky, United States of America.; Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America.
Hampton OA; Department of Bioinformatics and Biostatistics, M2Gen, Tampa, Florida, United States of America.
Rao M; Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Ueland FR; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Kentucky, Lexington, Kentucky, United States of America.; Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America.
Kolesar JM; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Kentucky, Lexington, Kentucky, United States of America.; College of Pharmacy, University of Kentucky, Lexington, Kentucky, United States of America.; Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America.
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Źródło:
PloS one [PLoS One] 2020 Dec 30; Vol. 15 (12), pp. e0244558. Date of Electronic Publication: 2020 Dec 30 (Print Publication: 2020).
Typ publikacji:
Comparative Study; Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Mutation Rate*
Endometrial Neoplasms/*pathology
Eye Proteins/*genetics
Transcription Factors/*genetics
Aged ; DNA Polymerase II/genetics ; Databases, Genetic ; Endometrial Neoplasms/genetics ; Female ; Humans ; Kentucky ; Microsatellite Instability ; Middle Aged ; Mismatch Repair Endonuclease PMS2/genetics ; MutL Protein Homolog 1/genetics ; Neoplasm Grading ; Poly-ADP-Ribose Binding Proteins/genetics ; Prevalence ; Prognosis ; Registries ; Sequence Analysis, RNA ; Exome Sequencing
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Protein expression-based classification of gastric cancer by immunohistochemistry of tissue microarray.
Autorzy:
Zhao C; Department of Gastroenterology, Guangzhou First People's Hospital, Medical School, South China University of Technology, Guangzhou, China.; Department of Gastroenterology, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
Feng Z; Department of Gastroenterology, Guangzhou First People's Hospital, Medical School, South China University of Technology, Guangzhou, China.; Department of Gastroenterology, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
He H; Department of Gastroenterology, Guangzhou First People's Hospital, Medical School, South China University of Technology, Guangzhou, China.; Department of Gastroenterology, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
Zang D; Department of Pathology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.
Du H; Department of Pathology, Guangzhou First People's Hospital, Medical School, South China University of Technology, Guangzhou, China.
Huang H; Department of Gastroenterology, Guangzhou First People's Hospital, Medical School, South China University of Technology, Guangzhou, China.; Department of Gastroenterology, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
Du Y; Department of Gastroenterology, Guangzhou First People's Hospital, Medical School, South China University of Technology, Guangzhou, China.; Department of Gastroenterology, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
He J; Department of Gastroenterology, Guangzhou First People's Hospital, Medical School, South China University of Technology, Guangzhou, China.; Department of Gastroenterology, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
Zhou Y; Department of Gastroenterology, Guangzhou First People's Hospital, Medical School, South China University of Technology, Guangzhou, China.; Department of Gastroenterology, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
Nie Y; Department of Gastroenterology, Guangzhou First People's Hospital, Medical School, South China University of Technology, Guangzhou, China.; Department of Gastroenterology, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
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Źródło:
PloS one [PLoS One] 2020 Oct 23; Vol. 15 (10), pp. e0238836. Date of Electronic Publication: 2020 Oct 23 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Neoplasm Proteins/*metabolism
Stomach Neoplasms/*classification
Stomach Neoplasms/*metabolism
Adult ; Aged ; Aged, 80 and over ; Antigens, CD/metabolism ; Biomarkers, Tumor/metabolism ; Cadherins/metabolism ; China ; Cohort Studies ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; DNA Mismatch Repair ; DNA-Binding Proteins/metabolism ; Female ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Mismatch Repair Endonuclease PMS2/metabolism ; MutL Protein Homolog 1/metabolism ; MutS Homolog 2 Protein/metabolism ; Prognosis ; Retrospective Studies ; Stomach Neoplasms/pathology ; Tissue Array Analysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cost-effectiveness analysis of genetic diagnostic strategies for Lynch syndrome in Italy.
Autorzy:
Pastorino R; Department of Woman and Child Health and Public Health-Public Health Area, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia.
Basile M; Università Cattolica del Sacro Cuore, Alta Scuola di Economia e Management dei Sistemi Sanitari (ALTEMS), Roma, Italia.
Tognetto A; Section of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Roma, Italia.
Di Marco M; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Grossi A; Section of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Roma, Italia.
Lucci-Cordisco E; Department of Laboratory and Infectious Sciences, Medical Genetics Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.; Dipartimento di Scienze della Vita e di Sanità Pubblica, Sezione di Medicina Genomica, Università Cattolica del Sacro Cuore, Rome, Italy.
Scaldaferri F; UOC Medicina Interna, Gastroenterologia e Malattie del Fegato, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
De Censi A; Medical Oncology Unit, Galliera Hospital, Genova, Italy.
Federici A; Direction of Prevention, Ministry of Health, Rome, Italy.
Villari P; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Genuardi M; Department of Laboratory and Infectious Sciences, Medical Genetics Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.; Dipartimento di Scienze della Vita e di Sanità Pubblica, Sezione di Medicina Genomica, Università Cattolica del Sacro Cuore, Rome, Italy.
Ricciardi W; Department of Woman and Child Health and Public Health-Public Health Area, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia.; Section of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Roma, Italia.
Boccia S; Department of Woman and Child Health and Public Health-Public Health Area, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia.; Section of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Roma, Italia.
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Źródło:
PloS one [PLoS One] 2020 Jul 01; Vol. 15 (7), pp. e0235038. Date of Electronic Publication: 2020 Jul 01 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Colorectal Neoplasms/*diagnosis
Colorectal Neoplasms, Hereditary Nonpolyposis/*diagnosis
Genetic Testing/*economics
Colorectal Neoplasms/economics ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms, Hereditary Nonpolyposis/economics ; Colorectal Neoplasms, Hereditary Nonpolyposis/epidemiology ; Colorectal Neoplasms, Hereditary Nonpolyposis/genetics ; Cost-Benefit Analysis ; DNA Mismatch Repair ; Genetic Testing/methods ; Humans ; Italy/epidemiology ; MutL Protein Homolog 1/genetics ; Pedigree ; Probability ; Quality-Adjusted Life Years
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
RPL22L1 induction in colorectal cancer is associated with poor prognosis and 5-FU resistance.
Autorzy:
Rao S; Center for Translational Medicine, Department of Surgery, George Washington University, Washington, DC, United States of America.
Peri S; Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA, United States of America.
Hoffmann J; Experimental Pharmacology & Oncology Berlin-Buch GMBH, Berlin-Buch, Germany.
Cai KQ; Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, United States of America.
Harris B; Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA, United States of America.
Rhodes M; Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA, United States of America.
Connolly DC; Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA, United States of America.
Testa JR; Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, United States of America.
Wiest DL; Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA, United States of America.
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Źródło:
PloS one [PLoS One] 2019 Oct 03; Vol. 14 (10), pp. e0222392. Date of Electronic Publication: 2019 Oct 03 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Drug Resistance, Neoplasm*
Colorectal Neoplasms/*drug therapy
Colorectal Neoplasms/*metabolism
Fluorouracil/*therapeutic use
RNA-Binding Proteins/*metabolism
Ribosomal Proteins/*metabolism
Animals ; Cell Proliferation ; Colorectal Neoplasms/pathology ; DNA Modification Methylases/metabolism ; DNA Repair Enzymes/metabolism ; Humans ; Mice ; MutL Protein Homolog 1/metabolism ; Prognosis ; Proto-Oncogene Proteins/metabolism ; Tumor Suppressor Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The prevalence and persistence of aberrant promoter DNA methylation in benzene-exposed Chinese workers.
Autorzy:
Ren J; Henan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, Medicine, School of Public Health, Xinxiang Medical University, Xinxiang, China.
Cui JP; Henan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, Medicine, School of Public Health, Xinxiang Medical University, Xinxiang, China.
Luo M; Henan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, Medicine, School of Public Health, Xinxiang Medical University, Xinxiang, China.
Liu H; Henan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, Medicine, School of Public Health, Xinxiang Medical University, Xinxiang, China.
Hao P; Xinxiang Center for Disease Control and Prevention, Xinxiang, China.
Wang X; Henan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, Medicine, School of Public Health, Xinxiang Medical University, Xinxiang, China.
Zhang GH; Henan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, Medicine, School of Public Health, Xinxiang Medical University, Xinxiang, China.
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Źródło:
PloS one [PLoS One] 2019 Aug 05; Vol. 14 (8), pp. e0220500. Date of Electronic Publication: 2019 Aug 05 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Benzene/*adverse effects
DNA Methylation/*drug effects
Environmental Pollutants/*adverse effects
Occupational Exposure/*adverse effects
Promoter Regions, Genetic/*drug effects
Adolescent ; Adult ; Aged ; Cell Line ; Female ; Humans ; Long Interspersed Nucleotide Elements/drug effects ; Male ; Middle Aged ; MutL Protein Homolog 1/genetics ; O(6)-Methylguanine-DNA Methyltransferase/genetics ; Occupational Exposure/analysis ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Genome-wide alteration in DNA hydroxymethylation in the sperm from bisphenol A-exposed men.
Autorzy:
Zheng H; Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai, China.; WHO Collaborating Center for Research in Human Reproduction, Shanghai, China.
Zhou X; Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai, China.; WHO Collaborating Center for Research in Human Reproduction, Shanghai, China.
Li DK; Division of Research, Kaiser Foundation Research Institute, Kaiser Permanente Northern California, Oakland, and Department of Health Research and Policy, School of Medicine, Stanford University, Stanford, California, United States of America.
Yang F; Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai, China.; WHO Collaborating Center for Research in Human Reproduction, Shanghai, China.
Pan H; Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai, China.; WHO Collaborating Center for Research in Human Reproduction, Shanghai, China.
Li T; Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai, China.; WHO Collaborating Center for Research in Human Reproduction, Shanghai, China.
Miao M; Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai, China.; WHO Collaborating Center for Research in Human Reproduction, Shanghai, China.
Li R; Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai, China.; WHO Collaborating Center for Research in Human Reproduction, Shanghai, China.
Yuan W; Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai, China.; WHO Collaborating Center for Research in Human Reproduction, Shanghai, China.
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Źródło:
PloS one [PLoS One] 2017 Jun 05; Vol. 12 (6), pp. e0178535. Date of Electronic Publication: 2017 Jun 05 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
Epigenesis, Genetic*
5-Methylcytosine/*analogs & derivatives
Air Pollutants, Occupational/*pharmacology
Benzhydryl Compounds/*pharmacology
Estrogens, Non-Steroidal/*pharmacology
Phenols/*pharmacology
Spermatogenesis/*drug effects
5-Methylcytosine/metabolism ; Adult ; DNA Methylation ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Environmental Exposure/adverse effects ; Genome, Human ; Histones/genetics ; Histones/metabolism ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Humans ; Hydroxylation ; Male ; Middle Aged ; MutL Protein Homolog 1/genetics ; MutL Protein Homolog 1/metabolism ; Promoter Regions, Genetic ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Sperm Count ; Spermatozoa/drug effects ; Spermatozoa/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
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