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Wyszukujesz frazę ""MutL Protein Homolog 1"" wg kryterium: Temat


Tytuł:
Target gene mutational pattern in Lynch syndrome colorectal carcinomas according to tumour location and germline mutation.
Autorzy:
Pinheiro M; Department of Genetics, Portuguese Oncology Institute, Rua Doutor António Bernardino Almeida, 4200-072 Porto, Portugal.
Pinto C; Department of Genetics, Portuguese Oncology Institute, Rua Doutor António Bernardino Almeida, 4200-072 Porto, Portugal.
Peixoto A; Department of Genetics, Portuguese Oncology Institute, Rua Doutor António Bernardino Almeida, 4200-072 Porto, Portugal.
Veiga I; Department of Genetics, Portuguese Oncology Institute, Rua Doutor António Bernardino Almeida, 4200-072 Porto, Portugal.
Lopes P; Department of Pathology, Portuguese Oncology Institute, Rua Doutor António Bernardino Almeida, 4200-072 Porto, Portugal.
Henrique R; 1] Department of Pathology, Portuguese Oncology Institute, Rua Doutor António Bernardino Almeida, 4200-072 Porto, Portugal [2] Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, University of Porto, Largo Professor Abel Salazar, 4099-003 Porto, Portugal.
Baldaia H; Department of Pathology, Centro Hospitalar de São João, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal.
Carneiro F; 1] Department of Pathology, Centro Hospitalar de São João, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal [2] Medical Faculty of the University of Porto, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal [3] Instituto de Investigação e Inovação em Saúde, Universidade do Porto and Institute of Molecular Pathology and Immunology of the University of Porto, Rua Dr Roberto Frias, 4200-465 Porto, Portugal.
Seruca R; 1] Medical Faculty of the University of Porto, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal [2] Instituto de Investigação e Inovação em Saúde, Universidade do Porto and Institute of Molecular Pathology and Immunology of the University of Porto, Rua Dr Roberto Frias, 4200-465 Porto, Portugal.
Tomlinson I; 1] Molecular and Population Genetics Laboratory, Nuffield Department of Clinical Medicine, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK [2] Oxford NIHR Comprehensive Biomedical Research Centre, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.
Kovac M; 1] Research Group Human Genomics, Department of Biomedicine, University of Basel, Hebelstrasse 20, 4031 Basel, Switzerland [2] Medical Genetics, University Hospital Basel, Burgfelderstrasse 101, 4055 Basel, Switzerland.
Heinimann K; 1] Research Group Human Genomics, Department of Biomedicine, University of Basel, Hebelstrasse 20, 4031 Basel, Switzerland [2] Medical Genetics, University Hospital Basel, Burgfelderstrasse 101, 4055 Basel, Switzerland.
Teixeira MR; 1] Department of Genetics, Portuguese Oncology Institute, Rua Doutor António Bernardino Almeida, 4200-072 Porto, Portugal [2] Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, University of Porto, Largo Professor Abel Salazar, 4099-003 Porto, Portugal.
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Źródło:
British journal of cancer [Br J Cancer] 2015 Aug 11; Vol. 113 (4), pp. 686-92. Date of Electronic Publication: 2015 Aug 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Colorectal Neoplasms/*genetics
Colorectal Neoplasms, Hereditary Nonpolyposis/*genetics
Germ-Line Mutation/*genetics
Activin Receptors, Type II/genetics ; Adaptor Proteins, Signal Transducing/genetics ; Adolescent ; Adult ; Aged ; Bone Morphogenetic Protein Receptors, Type II/genetics ; Carcinogenesis/genetics ; DNA-Binding Proteins/genetics ; Female ; Humans ; Male ; Microsatellite Instability ; Middle Aged ; MutL Protein Homolog 1 ; MutS Homolog 2 Protein/genetics ; MutS Homolog 3 Protein ; Nuclear Proteins/genetics ; Protein Serine-Threonine Kinases/genetics ; Receptor, Transforming Growth Factor-beta Type II ; Receptors, Transforming Growth Factor beta/genetics ; Young Adult
Czasopismo naukowe
Tytuł:
A randomised, phase II trial of the DNA-hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in combination with carboplatin vs carboplatin alone in patients with recurrent, partially platinum-sensitive ovarian cancer.
Autorzy:
Glasspool RM; The Beatson West of Scotland Cancer Centre, 1053 Great Western Road, Glasgow G12 0YN, UK.
Brown R; Department Surgery and Cancer, Imperial College London, Hammersmith Hospital, London W12 0NN, UK.
Gore ME; Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey SM2 5PT, UK.
Rustin GJ; Mount Vernon Cancer Centre, Northwood, Middlesex HA6 2RN, UK.
McNeish IA; St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK.
Wilson RH; Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast BT9 7AB, N. Ireland, UK.
Pledge S; Sheffield Weston Park Hospital, Whitham Road, Sheffield, South Yorkshire S10 2SJ, UK.
Paul J; The Beatson West of Scotland Cancer Centre, 1053 Great Western Road, Glasgow G12 0YN, UK.
Mackean M; Edinburgh Western General Hospital, Crewe Road S, Edinburgh EH4 2XU, UK.
Hall GD; St James's Institute of Oncology, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK.
Gabra H; Department Surgery and Cancer, Imperial College London, Hammersmith Hospital, London W12 0NN, UK.
Halford SE; Drug Development Office Cancer Research UK, Angel Building, 407 Street, John Street, Islington, London EC1V 4AD, UK.
Walker J; Analytical Services Unit, Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow G61 1QH, UK.
Appleton K; Analytical Services Unit, Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow G61 1QH, UK.
Ullah R; Analytical Services Unit, Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow G61 1QH, UK.
Kaye S; Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey SM2 5PT, UK.
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Corporate Authors:
Scottish Gynaecological Trials Group
Źródło:
British journal of cancer [Br J Cancer] 2014 Apr 15; Vol. 110 (8), pp. 1923-9. Date of Electronic Publication: 2014 Mar 18.
Typ publikacji:
Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Azacitidine/*analogs & derivatives
Carboplatin/*administration & dosage
DNA Methylation/*genetics
Neoplasm Recurrence, Local/*drug therapy
Ovarian Neoplasms/*drug therapy
Adaptor Proteins, Signal Transducing/blood ; Adaptor Proteins, Signal Transducing/genetics ; Aged ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Azacitidine/administration & dosage ; Azacitidine/adverse effects ; Carboplatin/adverse effects ; Decitabine ; Drug Resistance, Neoplasm ; Female ; Humans ; Middle Aged ; MutL Protein Homolog 1 ; Neoplasm Recurrence, Local/genetics ; Neoplasm Recurrence, Local/pathology ; Nuclear Proteins/blood ; Nuclear Proteins/genetics ; Ovarian Neoplasms/blood ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology ; Platinum/administration & dosage
Czasopismo naukowe
Tytuł:
Cytosine-based nucleoside analogs are selectively lethal to DNA mismatch repair-deficient tumour cells by enhancing levels of intracellular oxidative stress.
Autorzy:
Hewish M; The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK.
Martin SA
Elliott R
Cunningham D
Lord CJ
Ashworth A
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Źródło:
British journal of cancer [Br J Cancer] 2013 Mar 05; Vol. 108 (4), pp. 983-92. Date of Electronic Publication: 2013 Jan 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adaptor Proteins, Signal Transducing/*genetics
Antimetabolites, Antineoplastic/*therapeutic use
Cytarabine/*pharmacology
DNA Mismatch Repair/*drug effects
DNA Repair-Deficiency Disorders/*drug therapy
MutS Homolog 2 Protein/*genetics
Neoplasms/*genetics
Nuclear Proteins/*genetics
Oxidative Stress/*drug effects
Cell Line, Tumor ; Humans ; MutL Protein Homolog 1 ; Nucleosides ; Oxidative Stress/genetics
Czasopismo naukowe
Tytuł:
Frequency of mutations in mismatch repair genes in a population-based study of women with ovarian cancer.
Autorzy:
Pal T; Departments of Cancer Epidemiology, Biostatistics, Anatomic Pathology and Experimental Therapeutics, Moffitt Cancer Center, MRC-CANCONT, 12902 Magnolia Drive, Tampa, FL 33612, USA. />Akbari MR
Sun P
Lee JH
Fulp J
Thompson Z
Coppola D
Nicosia S
Sellers TA
McLaughlin J
Risch HA
Rosen B
Shaw P
Schildkraut J
Narod SA
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Źródło:
British journal of cancer [Br J Cancer] 2012 Nov 06; Vol. 107 (10), pp. 1783-90. Date of Electronic Publication: 2012 Oct 09.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
DNA Mismatch Repair*
Mutation*
Neoplasms, Glandular and Epithelial/*genetics
Ovarian Neoplasms/*genetics
Adaptor Proteins, Signal Transducing/genetics ; Carcinoma, Ovarian Epithelial ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms, Hereditary Nonpolyposis/genetics ; DNA-Binding Proteins/genetics ; Female ; Humans ; Middle Aged ; MutL Protein Homolog 1 ; MutS Homolog 2 Protein/genetics ; Nuclear Proteins/genetics
Czasopismo naukowe
Tytuł:
Mismatch repair deficiency: a temozolomide resistance factor in medulloblastoma cell lines that is uncommon in primary medulloblastoma tumours.
Autorzy:
von Bueren AO; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Germany. />Bacolod MD
Hagel C
Heinimann K
Fedier A
Kordes U
Pietsch T
Koster J
Grotzer MA
Friedman HS
Marra G
Kool M
Rutkowski S
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Źródło:
British journal of cancer [Br J Cancer] 2012 Oct 09; Vol. 107 (8), pp. 1399-408. Date of Electronic Publication: 2012 Sep 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adaptor Proteins, Signal Transducing/*genetics
Antineoplastic Agents, Alkylating/*therapeutic use
Cerebellar Neoplasms/*genetics
DNA Mismatch Repair/*genetics
Dacarbazine/*analogs & derivatives
Drug Resistance, Neoplasm/*genetics
Medulloblastoma/*genetics
Nuclear Proteins/*genetics
Adaptor Proteins, Signal Transducing/biosynthesis ; Cell Line, Tumor ; Cerebellar Neoplasms/drug therapy ; Cerebellar Neoplasms/metabolism ; Child ; Child, Preschool ; DNA Modification Methylases/biosynthesis ; DNA Modification Methylases/genetics ; DNA Repair Enzymes/biosynthesis ; DNA Repair Enzymes/genetics ; Dacarbazine/therapeutic use ; Female ; Humans ; Male ; Medulloblastoma/drug therapy ; Medulloblastoma/metabolism ; MutL Protein Homolog 1 ; Nuclear Proteins/biosynthesis ; O(6)-Methylguanine-DNA Methyltransferase/metabolism ; Temozolomide ; Tumor Suppressor Proteins/biosynthesis ; Tumor Suppressor Proteins/genetics
Czasopismo naukowe
Tytuł:
Body mass index in early adulthood and colorectal cancer risk for carriers and non-carriers of germline mutations in DNA mismatch repair genes.
Autorzy:
Win AK; Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Melbourne School of Population Health, Level 3, 207 Bouverie Street, Parkville, Victoria 3010, Australia.
Dowty JG
English DR
Campbell PT
Young JP
Winship I
Macrae FA
Lipton L
Parry S
Young GP
Buchanan DD
Martínez ME
Jacobs ET
Ahnen DJ
Haile RW
Casey G
Baron JA
Lindor NM
Thibodeau SN
Newcomb PA
Potter JD
Le Marchand L
Gallinger S
Hopper JL
Jenkins MA
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Źródło:
British journal of cancer [Br J Cancer] 2011 Jun 28; Vol. 105 (1), pp. 162-9. Date of Electronic Publication: 2011 May 10.
Typ publikacji:
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Body Mass Index*
Adaptor Proteins, Signal Transducing/*genetics
Adenosine Triphosphatases/*genetics
Colorectal Neoplasms/*genetics
DNA Repair Enzymes/*genetics
DNA-Binding Proteins/*genetics
Germ-Line Mutation/*genetics
MutS Homolog 2 Protein/*genetics
Nuclear Proteins/*genetics
Adult ; DNA Mismatch Repair ; Female ; Follow-Up Studies ; Heterozygote ; Humans ; Male ; Middle Aged ; Mismatch Repair Endonuclease PMS2 ; MutL Protein Homolog 1 ; Prognosis ; Risk Factors ; Young Adult
Czasopismo naukowe
Tytuł:
MLH1 mediates PARP-dependent cell death in response to the methylating agent N-methyl-N-nitrosourea.
Autorzy:
McDaid JR; Stem Cells and Epigenetics Research Group, Centre for Molecular Biosciences, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland, UK.
Loughery J
Dunne P
Boyer JC
Downes CS
Farber RA
Walsh CP
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Źródło:
British journal of cancer [Br J Cancer] 2009 Aug 04; Vol. 101 (3), pp. 441-51. Date of Electronic Publication: 2009 Jul 21.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Adaptor Proteins, Signal Transducing/*physiology
Alkylating Agents/*pharmacology
Apoptosis/*drug effects
Methylnitrosourea/*pharmacology
Nuclear Proteins/*physiology
Poly(ADP-ribose) Polymerases/*physiology
Ataxia Telangiectasia Mutated Proteins ; Caspases/physiology ; Cell Cycle/drug effects ; Cell Cycle Proteins/physiology ; Cell Line, Tumor ; Cell Survival/drug effects ; DNA-Binding Proteins/physiology ; Histones/metabolism ; Humans ; Isoquinolines/pharmacology ; MutL Protein Homolog 1 ; Phosphorylation ; Piperidines/pharmacology ; Protein Serine-Threonine Kinases/physiology ; Telomerase/physiology ; Thioguanine/pharmacology ; Tumor Suppressor Protein p53/physiology ; Tumor Suppressor Proteins/physiology
Czasopismo naukowe
Tytuł:
Combined inhibition of DNA methylation and histone acetylation enhances gene re-expression and drug sensitivity in vivo.
Autorzy:
Steele N; Centre for Oncology and Applied Pharmacology, University of Glasgow, UK.
Finn P
Brown R
Plumb JA
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Źródło:
British journal of cancer [Br J Cancer] 2009 Mar 10; Vol. 100 (5), pp. 758-63.
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
DNA (Cytosine-5-)-Methyltransferases/*antagonists & inhibitors
Drug Resistance, Neoplasm/*drug effects
Enzyme Inhibitors/*administration & dosage
Gene Expression Regulation, Neoplastic/*drug effects
Histone Acetyltransferases/*antagonists & inhibitors
Ovarian Neoplasms/*drug therapy
Acetylation/drug effects ; Adaptor Proteins, Signal Transducing/genetics ; Animals ; Antigens, Neoplasm/genetics ; Antigens, Neoplasm/metabolism ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Azacitidine/administration & dosage ; Azacitidine/analogs & derivatives ; Azacitidine/pharmacology ; DNA Methylation/drug effects ; Decitabine ; Drug Resistance, Neoplasm/genetics ; Enzyme Inhibitors/pharmacology ; Female ; Humans ; Hydroxamic Acids/administration & dosage ; Melanoma-Specific Antigens ; Mice ; Mice, Nude ; MutL Protein Homolog 1 ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Nuclear Proteins/genetics ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/metabolism ; Ovarian Neoplasms/pathology ; Sulfonamides ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł:
The G67E mutation in hMLH1 is associated with an unusual presentation of Lynch syndrome.
Autorzy:
Clyne M; MRC Genome Damage and Stability Centre, University of Sussex, Brighton, UK.
Offman J
Shanley S
Virgo JD
Radulovic M
Wang Y
Ardern-Jones A
Eeles R
Hoffmann E
Yu VP
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Źródło:
British journal of cancer [Br J Cancer] 2009 Jan 27; Vol. 100 (2), pp. 376-80. Date of Electronic Publication: 2009 Jan 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adaptor Proteins, Signal Transducing/*genetics
Colorectal Neoplasms, Hereditary Nonpolyposis/*genetics
DNA Mismatch Repair/*genetics
Mutation/*genetics
Nuclear Proteins/*genetics
Adaptor Proteins, Signal Transducing/metabolism ; Colorectal Neoplasms, Hereditary Nonpolyposis/metabolism ; Colorectal Neoplasms, Hereditary Nonpolyposis/pathology ; Family ; Genetic Complementation Test ; Humans ; Immunoblotting ; Male ; Middle Aged ; MutL Protein Homolog 1 ; Nuclear Proteins/metabolism ; Phenotype ; Saccharomycetales
Czasopismo naukowe
Tytuł:
Deficient mismatch repair system in patients with sporadic advanced colorectal cancer.
Autorzy:
Koopman M; Department of Medical Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. />Kortman GA
Mekenkamp L
Ligtenberg MJ
Hoogerbrugge N
Antonini NF
Punt CJ
van Krieken JH
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Źródło:
British journal of cancer [Br J Cancer] 2009 Jan 27; Vol. 100 (2), pp. 266-73.
Typ publikacji:
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Adenocarcinoma/*genetics
Adenocarcinoma, Mucinous/*genetics
Carcinoma, Adenosquamous/*genetics
Colorectal Neoplasms/*genetics
DNA Mismatch Repair/*genetics
Adaptor Proteins, Signal Transducing ; Adenocarcinoma/drug therapy ; Adenocarcinoma/secondary ; Adenocarcinoma, Mucinous/drug therapy ; Adenocarcinoma, Mucinous/secondary ; Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Camptothecin/administration & dosage ; Camptothecin/analogs & derivatives ; Capecitabine ; Carcinoma, Adenosquamous/drug therapy ; Carcinoma, Adenosquamous/secondary ; Clinical Trials, Phase III as Topic ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/pathology ; DNA Methylation ; Deoxycytidine/administration & dosage ; Deoxycytidine/analogs & derivatives ; Female ; Fluorouracil/administration & dosage ; Fluorouracil/analogs & derivatives ; Humans ; Immunoenzyme Techniques ; Incidence ; Irinotecan ; Male ; Microsatellite Instability ; Middle Aged ; MutL Protein Homolog 1 ; Nuclear Proteins ; Organoplatinum Compounds/administration & dosage ; Oxaliplatin ; Prognosis ; Promoter Regions, Genetic/genetics ; Randomized Controlled Trials as Topic ; Survival Rate ; Treatment Outcome
Czasopismo naukowe
Tytuł:
Microsatellite instability due to hMLH1 deficiency is associated with increased cytotoxicity to irinotecan in human colorectal cancer cell lines.
Autorzy:
Vilar E; Department of Medical Oncology and Laboratory of Oncology Research, Vall d'Hebron University Hospital, Barcelona, Spain. />Scaltriti M
Balmaña J
Saura C
Guzman M
Arribas J
Baselga J
Tabernero J
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Źródło:
British journal of cancer [Br J Cancer] 2008 Nov 18; Vol. 99 (10), pp. 1607-12. Date of Electronic Publication: 2008 Oct 21.
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
Microsatellite Instability*
Adaptor Proteins, Signal Transducing/*genetics
Antineoplastic Agents, Phytogenic/*pharmacology
Camptothecin/*analogs & derivatives
Colorectal Neoplasms/*drug therapy
DNA Repair Enzymes/*genetics
Nuclear Proteins/*genetics
Acid Anhydride Hydrolases ; Camptothecin/pharmacology ; Cell Line, Tumor/drug effects ; Cytotoxins/pharmacology ; DNA-Binding Proteins/genetics ; Humans ; Irinotecan ; MRE11 Homologue Protein ; MutL Protein Homolog 1
Czasopismo naukowe
Tytuł:
DLEC1 and MLH1 promoter methylation are associated with poor prognosis in non-small cell lung carcinoma.
Autorzy:
Seng TJ; Cancer Research Program, Garvan Institute of Medical Research, Sydney 2010, Australia.
Currey N
Cooper WA
Lee CS
Chan C
Horvath L
Sutherland RL
Kennedy C
McCaughan B
Kohonen-Corish MR
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Źródło:
British journal of cancer [Br J Cancer] 2008 Jul 22; Vol. 99 (2), pp. 375-82. Date of Electronic Publication: 2008 Jul 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA Methylation*
Adaptor Proteins, Signal Transducing/*genetics
Carcinoma, Non-Small-Cell Lung/*genetics
Lung Neoplasms/*genetics
Nuclear Proteins/*genetics
Tumor Suppressor Proteins/*genetics
Adult ; Aged ; Aged, 80 and over ; Carcinoma, Non-Small-Cell Lung/pathology ; Chromosomes, Human, Pair 3 ; Cytoskeletal Proteins ; Female ; Genes, Tumor Suppressor ; Humans ; Lung Neoplasms/pathology ; Male ; Microsatellite Instability ; Middle Aged ; MutL Protein Homolog 1 ; Prognosis ; Promoter Regions, Genetic ; Receptors, Retinoic Acid/genetics
Czasopismo naukowe
Tytuł:
Patients with an unexplained microsatellite instable tumour have a low risk of familial cancer.
Autorzy:
Overbeek LI; Department of Human Genetics 849, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.
Kets CM
Hebeda KM
Bodmer D
van der Looij E
Willems R
Goossens M
Arts N
Brunner HG
van Krieken JH
Hoogerbrugge N
Ligtenberg MJ
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Źródło:
British journal of cancer [Br J Cancer] 2007 May 21; Vol. 96 (10), pp. 1605-12. Date of Electronic Publication: 2007 Apr 24.
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
Genetic Predisposition to Disease*
Microsatellite Instability*
Carcinoma/*genetics
Colorectal Neoplasms/*genetics
Colorectal Neoplasms, Hereditary Nonpolyposis/*genetics
Adaptor Proteins, Signal Transducing/genetics ; Adult ; Aged ; Algorithms ; DNA Methylation ; DNA Mismatch Repair ; DNA-Binding Proteins/genetics ; Family ; Germ-Line Mutation ; Humans ; Middle Aged ; MutL Protein Homolog 1 ; MutS Homolog 2 Protein/genetics ; Nuclear Proteins/genetics ; Promoter Regions, Genetic ; Risk Factors
Czasopismo naukowe
Tytuł:
The role of MYH and microsatellite instability in the development of sporadic colorectal cancer.
Autorzy:
Colebatch A; Department of Medical Oncology, St Vincent's Hospital, Victoria Street, Darlinghurst, NSW 2010, Australia.
Hitchins M
Williams R
Meagher A
Hawkins NJ
Ward RL
Pokaż więcej
Źródło:
British journal of cancer [Br J Cancer] 2006 Nov 06; Vol. 95 (9), pp. 1239-43. Date of Electronic Publication: 2006 Oct 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Microsatellite Instability*
Colorectal Neoplasms/*genetics
DNA Glycosylases/*genetics
Adaptor Proteins, Signal Transducing ; Adult ; Aged ; Aged, 80 and over ; Australia ; Base Sequence ; Carrier Proteins/genetics ; Cohort Studies ; Colorectal Neoplasms/etiology ; Colorectal Neoplasms/pathology ; DNA Glycosylases/metabolism ; DNA Methylation ; DNA Mutational Analysis ; Female ; Gene Frequency ; Germ-Line Mutation/genetics ; Heterozygote ; Humans ; Lymphocytes, Tumor-Infiltrating/metabolism ; Lymphocytes, Tumor-Infiltrating/pathology ; Male ; Middle Aged ; MutL Protein Homolog 1 ; Nuclear Proteins/genetics ; Pedigree ; Polymorphism, Genetic/genetics ; Promoter Regions, Genetic/genetics
Czasopismo naukowe
Tytuł:
Genetic and epigenetic changes in the development of multiple colorectal cancers in the general population.
Autorzy:
Watanabe T
Kanazawa T
Kazama Y
Tanaka J
Tanaka T
Tada T
Nagawa H
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Źródło:
British journal of cancer [Br J Cancer] 2005 Nov 28; Vol. 93 (11), pp. 1317.
Typ publikacji:
Letter; Comment
MeSH Terms:
Epigenesis, Genetic*
Adenoma/*genetics
Colorectal Neoplasms/*genetics
Neoplasms, Multiple Primary/*genetics
Adaptor Proteins, Signal Transducing ; Carrier Proteins/genetics ; Humans ; MutL Protein Homolog 1 ; Nuclear Proteins/genetics ; Phenotype ; Risk Factors
Opinia redakcyjna
Tytuł:
Aspirin-induced nuclear translocation of NFkappaB and apoptosis in colorectal cancer is independent of p53 status and DNA mismatch repair proficiency.
Autorzy:
Din FV; Department of Oncology, Division of Clinical and Molecular Medicine and MRC Human Genetics Unit, Western General Hospital, University of Edinburgh, Crewe Rd, Edinburgh EH4 2XU, Scotland, UK.
Stark LA
Dunlop MG
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Źródło:
British journal of cancer [Br J Cancer] 2005 Mar 28; Vol. 92 (6), pp. 1137-43.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Base Pair Mismatch*
Active Transport, Cell Nucleus/*drug effects
Apoptosis/*drug effects
Aspirin/*pharmacology
Colorectal Neoplasms/*drug therapy
NF-kappa B/*metabolism
Adaptor Proteins, Signal Transducing ; Carrier Proteins ; Cell Line, Tumor ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Humans ; I-kappa B Proteins/metabolism ; MutL Protein Homolog 1 ; NF-KappaB Inhibitor alpha ; Neoplasm Proteins/physiology ; Nuclear Proteins ; Tumor Suppressor Protein p53/physiology
Czasopismo naukowe
Tytuł:
hMSH2 is the most commonly mutated MMR gene in a cohort of Greek HNPCC patients.
Autorzy:
Apessos A; Molecular Biology Research Center HYGEIA - Antonis Papayiannis, Kifissias Ave & Erythrou Stavrou 4 Str, 15123 Maroussi, Athens, Greece.
Mihalatos M
Danielidis I
Kallimanis G
Agnantis NJ
Triantafillidis JK
Fountzilas G
Kosmidis PA
Razis E
Georgoulias VA
Nasioulas G
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Źródło:
British journal of cancer [Br J Cancer] 2005 Jan 31; Vol. 92 (2), pp. 396-404.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Colorectal Neoplasms, Hereditary Nonpolyposis/*genetics
DNA-Binding Proteins/*genetics
Proto-Oncogene Proteins/*genetics
Adaptor Proteins, Signal Transducing ; Base Sequence ; Carrier Proteins ; Chromatography, High Pressure Liquid ; Colorectal Neoplasms, Hereditary Nonpolyposis/epidemiology ; Female ; Greece ; Humans ; Male ; MutL Protein Homolog 1 ; MutS Homolog 2 Protein ; Mutation ; Neoplasm Proteins/genetics ; Nuclear Proteins ; Pedigree ; Reverse Transcriptase Polymerase Chain Reaction
Czasopismo naukowe

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