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Wyszukujesz frazę ""MutL Protein Homolog 1"" wg kryterium: Temat


Tytuł :
Switch/sucrose nonfermenting nucleosome complex-deficient colorectal carcinomas have distinct clinicopathologic features.
Autorzy :
Villatoro TM; Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Ma C; Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Pai RK; Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. Electronic address: .
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Źródło :
Human pathology [Hum Pathol] 2020 May; Vol. 99, pp. 53-61. Date of Electronic Publication: 2020 Mar 25.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Adenocarcinoma/*chemistry
Biomarkers, Tumor/*analysis
Colorectal Neoplasms/*chemistry
DNA Helicases/*analysis
DNA-Binding Proteins/*analysis
Nuclear Proteins/*analysis
SMARCB1 Protein/*analysis
Transcription Factors/*analysis
Adenocarcinoma/genetics ; Adenocarcinoma/pathology ; Adenocarcinoma/surgery ; Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/genetics ; Cell Differentiation ; Cell Proliferation ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/surgery ; DNA Mismatch Repair ; Female ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; MutL Protein Homolog 1/analysis ; Prognosis ; Retrospective Studies ; Tissue Array Analysis ; Young Adult
Czasopismo naukowe
Tytuł :
Loss of MLH1 sensitizes colon cancer cells to DNA-PKcs inhibitor KU60648.
Autorzy :
Hinrichsen I; Medical Clinic I, Biomedical Research Laboratory, Goethe-University, Frankfurt a.M., Germany.
Ackermann A; Medical Clinic I, Biomedical Research Laboratory, Goethe-University, Frankfurt a.M., Germany.
Düding T; Medical Clinic I, Biomedical Research Laboratory, Goethe-University, Frankfurt a.M., Germany.
Graband A; Medical Clinic I, Biomedical Research Laboratory, Goethe-University, Frankfurt a.M., Germany.
Filmann N; Institute of Biostatistics and Mathematical Modeling, Goethe University Frankfurt, Germany.
Plotz G; Medical Clinic I, Biomedical Research Laboratory, Goethe-University, Frankfurt a.M., Germany.
Zeuzem S; Medical Clinic I, Biomedical Research Laboratory, Goethe-University, Frankfurt a.M., Germany.
Brieger A; Medical Clinic I, Biomedical Research Laboratory, Goethe-University, Frankfurt a.M., Germany.
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Źródło :
Molecular carcinogenesis [Mol Carcinog] 2017 Jul; Vol. 56 (7), pp. 1816-1824. Date of Electronic Publication: 2017 Mar 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Colonic Neoplasms/*drug therapy
DNA-Activated Protein Kinase/*antagonists & inhibitors
Drug Resistance, Neoplasm/*drug effects
MutL Protein Homolog 1/*antagonists & inhibitors
Nuclear Proteins/*antagonists & inhibitors
Protein Kinase Inhibitors/*pharmacology
Apoptosis/drug effects ; Cell Proliferation/drug effects ; Colonic Neoplasms/metabolism ; Colonic Neoplasms/pathology ; DNA Mismatch Repair/drug effects ; Humans ; MutL Protein Homolog 1/genetics ; MutL Protein Homolog 1/metabolism ; RNA, Small Interfering/genetics ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Morphological Features and Prognostic Significance of ARID1A-Deficient Esophageal Adenocarcinomas.
Autorzy :
Drage MG
Tippayawong M
Agoston AT
Zheng Y
Bueno R
Hornick JL
Odze RD
Srivastava A; From the Departments of Pathology (Drs Drage, Tippayawong, Agoston, Hornick, Odze, and Srivastava) and Surgery (Drs Zheng and Bueno), Brigham and Women's Hospital, Boston, Massachusetts. Dr Drage is now with the Department of Pathology, University of Rochester Medical Center, Rochester, New York.
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Źródło :
Archives of pathology & laboratory medicine [Arch Pathol Lab Med] 2017 Jul; Vol. 141 (7), pp. 970-977. Date of Electronic Publication: 2017 Apr 25.
Typ publikacji :
Journal Article
MeSH Terms :
Adenocarcinoma/*genetics
Adenocarcinoma/*pathology
Esophageal Neoplasms/*genetics
Esophageal Neoplasms/*pathology
Nuclear Proteins/*deficiency
Transcription Factors/*deficiency
Adult ; Aged ; Aged, 80 and over ; DNA-Binding Proteins ; Female ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Male ; Middle Aged ; MutL Protein Homolog 1/biosynthesis ; MutL Protein Homolog 1/genetics ; Nuclear Proteins/genetics ; Prognosis ; Transcription Factors/genetics
SCR Disease Name :
Adenocarcinoma Of Esophagus
Czasopismo naukowe
Tytuł :
PD-L1 expression in HNPCC-associated colorectal cancer.
Autorzy :
Shiraliyeva N; Institute of Pathology, University of Cologne Medical School, Kerpener Str. 62, 50937, Cologne, Germany.
Friedrichs J; Institute of Pathology, University of Cologne Medical School, Kerpener Str. 62, 50937, Cologne, Germany.
Buettner R; Institute of Pathology, University of Cologne Medical School, Kerpener Str. 62, 50937, Cologne, Germany.
Friedrichs N; Institute of Pathology, University of Cologne Medical School, Kerpener Str. 62, 50937, Cologne, Germany. Electronic address: .
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Źródło :
Pathology, research and practice [Pathol Res Pract] 2017 Dec; Vol. 213 (12), pp. 1552-1555. Date of Electronic Publication: 2017 Sep 18.
Typ publikacji :
Journal Article
MeSH Terms :
B7-H1 Antigen/*metabolism
Colorectal Neoplasms/*metabolism
Colorectal Neoplasms, Hereditary Nonpolyposis/*metabolism
Nuclear Proteins/*metabolism
Adaptor Proteins, Signal Transducing/metabolism ; Adult ; Carrier Proteins/metabolism ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms, Hereditary Nonpolyposis/diagnosis ; DNA Mismatch Repair/physiology ; Female ; Humans ; Male ; Middle Aged ; MutL Protein Homolog 1/metabolism ; Mutation/genetics ; Nuclear Proteins/genetics
Czasopismo naukowe
Tytuł :
Associations Between Cancer Predisposition Testing Panel Genes and Breast Cancer.
Autorzy :
Couch FJ; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.; Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
Shimelis H; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
Hu C; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
Hart SN; Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
Polley EC; Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
Na J; Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
Hallberg E; Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
Moore R; Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
Thomas A; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
Lilyquist J; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
Feng B; Huntsman Cancer Institute, Department of Dermatology, University of Utah, Salt Lake City.
McFarland R; Department of Clinical Diagnostics, Ambry Genetics Inc, Aliso Viejo, California.
Pesaran T; Department of Clinical Diagnostics, Ambry Genetics Inc, Aliso Viejo, California.
Huether R; Department of Clinical Diagnostics, Ambry Genetics Inc, Aliso Viejo, California.
LaDuca H; Department of Clinical Diagnostics, Ambry Genetics Inc, Aliso Viejo, California.
Chao EC; Department of Clinical Diagnostics, Ambry Genetics Inc, Aliso Viejo, California.; Now, Division of Genetics and Genomics, Department of Pediatrics, University of California-Irvine.
Goldgar DE; Huntsman Cancer Institute, Department of Dermatology, University of Utah, Salt Lake City.
Dolinsky JS; Department of Clinical Diagnostics, Ambry Genetics Inc, Aliso Viejo, California.
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Źródło :
JAMA oncology [JAMA Oncol] 2017 Sep 01; Vol. 3 (9), pp. 1190-1196.
Typ publikacji :
Journal Article
MeSH Terms :
Genetic Predisposition to Disease*
Ataxia Telangiectasia Mutated Proteins/*genetics
Breast Neoplasms/*genetics
Checkpoint Kinase 2/*genetics
DNA-Binding Proteins/*genetics
Nuclear Proteins/*genetics
Ovarian Neoplasms/*genetics
Tumor Suppressor Proteins/*genetics
Ubiquitin-Protein Ligases/*genetics
Acid Anhydride Hydrolases ; Adult ; Case-Control Studies ; Cell Cycle Proteins/genetics ; Cyclin-Dependent Kinase Inhibitor p16 ; Cyclin-Dependent Kinase Inhibitor p18/genetics ; DNA Repair Enzymes/genetics ; European Continental Ancestry Group/genetics ; Fanconi Anemia Complementation Group N Protein ; Fanconi Anemia Complementation Group Proteins ; Female ; Genetic Testing ; Germ-Line Mutation ; Humans ; MRE11 Homologue Protein ; Middle Aged ; Mismatch Repair Endonuclease PMS2/genetics ; MutL Protein Homolog 1/genetics ; MutS Homolog 2 Protein/genetics ; Neurofibromin 1/genetics ; Phenotype ; RNA Helicases/genetics ; Risk Factors
Czasopismo naukowe
Tytuł :
The XY Body of the Cat (Felis catus): Structural Differentiations and Protein Immunolocalization.
Autorzy :
Sciurano RB; 2da. U.A. Biología Celular, Histología, Embriología y Genética, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
De Luca G
Rahn IM
Solari AJ
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Źródło :
Cytogenetic and genome research [Cytogenet Genome Res] 2017; Vol. 152 (3), pp. 137-147. Date of Electronic Publication: 2017 Aug 25.
Typ publikacji :
Journal Article
MeSH Terms :
Cats/*genetics
Nuclear Proteins/*metabolism
Pachytene Stage/*genetics
Synaptonemal Complex/*metabolism
X Chromosome/*metabolism
X Chromosome/*ultrastructure
Y Chromosome/*metabolism
Y Chromosome/*ultrastructure
Animals ; BRCA1 Protein/genetics ; BRCA1 Protein/metabolism ; Chromatin/metabolism ; Chromatin/ultrastructure ; Histones/genetics ; Histones/metabolism ; Male ; Microscopy, Fluorescence ; MutL Protein Homolog 1/genetics ; MutL Protein Homolog 1/metabolism ; Spermatocytes/metabolism ; Synaptonemal Complex/genetics
Czasopismo naukowe
Tytuł :
Mismatch Repair Protein Expression in Clear Cell Carcinoma of the Ovary: Incidence and Morphologic Associations in 109 Cases.
Autorzy :
Bennett JA; Departments of *Pathology ‡Surgery, Massachusetts General Hospital, Boston †Department of Pathology, Lahey Hospital and Medical Center, Burlington, MA §Department of Pathology, Stanford University, Stanford, CA.
Morales-Oyarvide V
Campbell S
Longacre TA
Oliva E
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Źródło :
The American journal of surgical pathology [Am J Surg Pathol] 2016 May; Vol. 40 (5), pp. 656-63.
Typ publikacji :
Journal Article; Multicenter Study
MeSH Terms :
DNA Mismatch Repair*
Adaptor Proteins, Signal Transducing/*analysis
Adenosine Triphosphatases/*analysis
Biomarkers, Tumor/*analysis
Carcinoma/*enzymology
Colorectal Neoplasms, Hereditary Nonpolyposis/*enzymology
DNA Repair Enzymes/*analysis
DNA-Binding Proteins/*analysis
MutS Homolog 2 Protein/*analysis
Nuclear Proteins/*analysis
Ovarian Neoplasms/*enzymology
Adult ; Aged ; Aged, 80 and over ; Biopsy ; Boston/epidemiology ; California/epidemiology ; Carcinoma/genetics ; Carcinoma/mortality ; Carcinoma/pathology ; Colorectal Neoplasms, Hereditary Nonpolyposis/genetics ; Colorectal Neoplasms, Hereditary Nonpolyposis/mortality ; Colorectal Neoplasms, Hereditary Nonpolyposis/pathology ; Female ; Humans ; Immunohistochemistry ; Incidence ; Kaplan-Meier Estimate ; Lymphocytes, Tumor-Infiltrating/pathology ; Middle Aged ; Mismatch Repair Endonuclease PMS2 ; MutL Protein Homolog 1 ; Neoplasm Staging ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/mortality ; Ovarian Neoplasms/pathology ; Stromal Cells/pathology ; Time Factors
Czasopismo naukowe
Tytuł :
Frequent mismatch-repair defects link prostate cancer to Lynch syndrome.
Autorzy :
Dominguez-Valentin M; Institute of Clinical Sciences, Division of Oncology and Pathology, Lund University, SE-22381, Lund, Sweden.
Joost P; Institute of Clinical Sciences, Division of Oncology and Pathology, Lund University, SE-22381, Lund, Sweden.
Therkildsen C; HNPCC-Register, Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark.
Jonsson M; Institute of Clinical Sciences, Division of Oncology and Pathology, Lund University, SE-22381, Lund, Sweden.
Rambech E; Institute of Clinical Sciences, Division of Oncology and Pathology, Lund University, SE-22381, Lund, Sweden.
Nilbert M; Institute of Clinical Sciences, Division of Oncology and Pathology, Lund University, SE-22381, Lund, Sweden. .; HNPCC-Register, Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark. .
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Źródło :
BMC urology [BMC Urol] 2016 Mar 24; Vol. 16, pp. 15. Date of Electronic Publication: 2016 Mar 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Registries*
Adaptor Proteins, Signal Transducing/*genetics
Adenocarcinoma/*genetics
Colorectal Neoplasms, Hereditary Nonpolyposis/*genetics
DNA-Binding Proteins/*genetics
MutS Homolog 2 Protein/*genetics
Nuclear Proteins/*genetics
Prostatic Neoplasms/*genetics
Aged ; Aged, 80 and over ; DNA Mismatch Repair/genetics ; Denmark ; Germ-Line Mutation ; Humans ; Immunohistochemistry ; Male ; Microsatellite Instability ; Middle Aged ; MutL Protein Homolog 1 ; Mutation
Czasopismo naukowe
Tytuł :
Polymorphisms in mismatch repair genes are associated with risk and microsatellite instability of gastric cancer, and interact with life exposures.
Autorzy :
Zhu H; The Cancer Therapy Center, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
Li X; The Cancer Therapy Center, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
Zhang X; Genetics and Molecular Biology Laboratory, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Chen D; The Cancer Therapy Center, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
Li D; The Cancer Therapy Center, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
Ren J; The Cancer Therapy Center, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
Gu H; The Cancer Therapy Center, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
Shu Y; Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. Electronic address: .
Wang D; The Cancer Therapy Center, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China; Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. Electronic address: .
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Źródło :
Gene [Gene] 2016 Mar 15; Vol. 579 (1), pp. 52-7. Date of Electronic Publication: 2015 Dec 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Microsatellite Instability*
Polymorphism, Single Nucleotide*
Adaptor Proteins, Signal Transducing/*genetics
Asian Continental Ancestry Group/*genetics
Nuclear Proteins/*genetics
Stomach Neoplasms/*genetics
Aged ; China ; DNA Repair Enzymes/genetics ; Exodeoxyribonucleases/genetics ; Female ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Male ; Middle Aged ; MutL Protein Homolog 1 ; MutS Homolog 2 Protein/genetics ; Phosphoproteins/genetics
Czasopismo naukowe
Tytuł :
An intact Pms2 ATPase domain is not essential for male fertility.
Autorzy :
Fischer JM; Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR 97239, USA.
Dudley S; Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR 97239, USA.
Miller AJ; Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR 97239, USA.
Liskay RM; Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR 97239, USA. Electronic address: .
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Źródło :
DNA repair [DNA Repair (Amst)] 2016 Mar; Vol. 39, pp. 46-51. Date of Electronic Publication: 2015 Dec 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
DNA Mismatch Repair*
Fertility*
Sequence Deletion*
Adaptor Proteins, Signal Transducing/*metabolism
Adenosine Triphosphatases/*metabolism
DNA Repair Enzymes/*metabolism
DNA-Binding Proteins/*metabolism
Nuclear Proteins/*metabolism
Testis/*metabolism
Adaptor Proteins, Signal Transducing/genetics ; Adenosine Triphosphatases/genetics ; Amino Acid Motifs ; Animals ; DNA Repair Enzymes/genetics ; DNA-Binding Proteins/genetics ; Gene Expression ; Male ; Mice ; Mice, Knockout ; Mismatch Repair Endonuclease PMS2 ; MutL Protein Homolog 1 ; Nuclear Proteins/genetics ; Testis/physiology
Czasopismo naukowe
Tytuł :
Constitutional Mismatch Repair Deficiency in Israel: High Proportion of Founder Mutations in MMR Genes and Consanguinity.
Autorzy :
Baris HN; The Genetics Institute, Rambam Health Care Campus, Haifa, Israel.; Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Barnes-Kedar I; The Raphael Recanati Genetic Institute, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel.
Toledano H; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Department of Pediatric Oncology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
Halpern M; Department of Pathology, Rabin Medical Center, Hasharon Hospital, Petach Tikva, Israel.
Hershkovitz D; Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.; Department of Pathology, Rambam Health Care Campus, Haifa, Israel.
Lossos A; Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Lerer I; Department of Human Genetics, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Peretz T; Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Kariv R; Department of Gastroenterology & Liver Disease, Sourasky Medical Center, Tel Aviv, Israel.
Cohen S; The Pediatric Gastroenterology Unit, Sourasky Medical Center, Tel Aviv, Israel.
Half EE; Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.; Department of Gastroenterology, Rambam Health Care Campus, Haifa, Israel.
Magal N; The Raphael Recanati Genetic Institute, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel.
Drasinover V; The Raphael Recanati Genetic Institute, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel.
Wimmer K; Division of Human Genetics, Medical University Innsbruck, Innsbruck, Austria.
Goldberg Y; Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Bercovich D; Human Molecular Genetics, Tel Hai College, Israel.
Levi Z; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Gastroenterology Division, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel.
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Źródło :
Pediatric blood & cancer [Pediatr Blood Cancer] 2016 Mar; Vol. 63 (3), pp. 418-27. Date of Electronic Publication: 2015 Nov 06.
Typ publikacji :
Journal Article
MeSH Terms :
Consanguinity*
Founder Effect*
Adaptor Proteins, Signal Transducing/*genetics
Adenosine Triphosphatases/*genetics
Colorectal Neoplasms, Hereditary Nonpolyposis/*genetics
DNA Mismatch Repair/*genetics
DNA Repair Enzymes/*genetics
DNA-Binding Proteins/*genetics
MutS Homolog 2 Protein/*genetics
Nuclear Proteins/*genetics
Adolescent ; Cafe-au-Lait Spots/genetics ; Child ; Child, Preschool ; Female ; Humans ; Immunohistochemistry ; Israel ; Lymphoma/genetics ; Male ; Mismatch Repair Endonuclease PMS2 ; MutL Protein Homolog 1 ; Mutation ; Pedigree ; Young Adult
Czasopismo naukowe
Tytuł :
Various ARID1A expression patterns and their clinical significance in gastric cancers.
Autorzy :
Kim YB; Department of Pathology, Ajou University School of Medicine, Suwon 443-380, Republic of Korea.
Ham IH; Department of Surgery, Ajou University School of Medicine, Suwon 443-380, Republic of Korea.
Hur H; Department of Surgery, Ajou University School of Medicine, Suwon 443-380, Republic of Korea.
Lee D; Department of Pathology, Ajou University School of Medicine, Suwon 443-380, Republic of Korea. Electronic address: .
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Źródło :
Human pathology [Hum Pathol] 2016 Mar; Vol. 49, pp. 61-70. Date of Electronic Publication: 2015 Nov 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenocarcinoma/*chemistry
Biomarkers, Tumor/*analysis
Nuclear Proteins/*analysis
Stomach Neoplasms/*chemistry
Transcription Factors/*analysis
Adaptor Proteins, Signal Transducing/analysis ; Adenocarcinoma/mortality ; Adenocarcinoma/pathology ; Adenocarcinoma/surgery ; Adult ; Aged ; Aged, 80 and over ; Biopsy ; Cell Differentiation ; DNA-Binding Proteins ; Disease-Free Survival ; Down-Regulation ; Female ; Gastrectomy ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Male ; Middle Aged ; MutL Protein Homolog 1 ; Predictive Value of Tests ; Proportional Hazards Models ; Ribosomal Protein S6 Kinases/analysis ; Risk Factors ; Stomach Neoplasms/mortality ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery ; Time Factors ; Treatment Outcome ; Young Adult
Czasopismo naukowe
Tytuł :
Gene methylation profile of gastric cancerous tissue according to tumor site in the stomach.
Autorzy :
Kupcinskaite-Noreikiene R; Oncology Institute of the Lithuanian University of Health Sciences, Eiveniu 2, Kaunas, 50009, Lithuania. .
Ugenskiene R; Oncology Institute of the Lithuanian University of Health Sciences, Eiveniu 2, Kaunas, 50009, Lithuania.
Noreika A; Kaunas University of Technology, Studentu 50, Kaunas, 50009, Lithuania.
Rudzianskas V; Oncology Institute of the Lithuanian University of Health Sciences, Eiveniu 2, Kaunas, 50009, Lithuania.
Gedminaite J; Oncology Institute of the Lithuanian University of Health Sciences, Eiveniu 2, Kaunas, 50009, Lithuania.
Skieceviciene J; Laboratory of Clinical and Molecular Gastroenterology, Lithuanian University of Health Sciences, Eiveniu 2, Kaunas, 50009, Lithuania.
Juozaityte E; Oncology Institute of the Lithuanian University of Health Sciences, Eiveniu 2, Kaunas, 50009, Lithuania.
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Źródło :
BMC cancer [BMC Cancer] 2016 Jan 26; Vol. 16, pp. 40. Date of Electronic Publication: 2016 Jan 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing/*genetics
DNA Methylation/*genetics
DNA Modification Methylases/*genetics
DNA Repair Enzymes/*genetics
Death-Associated Protein Kinases/*genetics
Nuclear Proteins/*genetics
Stomach Neoplasms/*genetics
Tumor Suppressor Proteins/*genetics
Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; MutL Protein Homolog 1 ; Neoplasm Staging ; Promoter Regions, Genetic ; Stomach/pathology ; Stomach Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Exonic Splicing Mutations Are More Prevalent than Currently Estimated and Can Be Predicted by Using In Silico Tools.
Autorzy :
Soukarieh O; Inserm U1079-IRIB, University of Rouen, Normandy Centre for Genomic and Personalized Medicine, Rouen, France.
Gaildrat P; Inserm U1079-IRIB, University of Rouen, Normandy Centre for Genomic and Personalized Medicine, Rouen, France.
Hamieh M; Inserm U1079-IRIB, University of Rouen, Normandy Centre for Genomic and Personalized Medicine, Rouen, France.
Drouet A; Inserm U1079-IRIB, University of Rouen, Normandy Centre for Genomic and Personalized Medicine, Rouen, France.
Baert-Desurmont S; Inserm U1079-IRIB, University of Rouen, Normandy Centre for Genomic and Personalized Medicine, Rouen, France.; Department of Genetics, University Hospital, Normandy Centre for Genomic and Personalized Medicine, Rouen, France.
Frébourg T; Inserm U1079-IRIB, University of Rouen, Normandy Centre for Genomic and Personalized Medicine, Rouen, France.; Department of Genetics, University Hospital, Normandy Centre for Genomic and Personalized Medicine, Rouen, France.
Tosi M; Inserm U1079-IRIB, University of Rouen, Normandy Centre for Genomic and Personalized Medicine, Rouen, France.
Martins A; Inserm U1079-IRIB, University of Rouen, Normandy Centre for Genomic and Personalized Medicine, Rouen, France.
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Źródło :
PLoS genetics [PLoS Genet] 2016 Jan 13; Vol. 12 (1), pp. e1005756. Date of Electronic Publication: 2016 Jan 13 (Print Publication: 2016).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing/*genetics
Exons/*genetics
Nuclear Proteins/*genetics
Ovarian Neoplasms/*genetics
RNA Splice Sites/*genetics
BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; Computer Simulation ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Female ; Humans ; MutL Protein Homolog 1 ; Neurofibromin 1/genetics ; Ovarian Neoplasms/pathology ; RNA Splicing/genetics
Czasopismo naukowe
Tytuł :
Clinicopathologic Risk Factor Distributions for MLH1 Promoter Region Methylation in CIMP-Positive Tumors.
Autorzy :
Levine AJ; Stanford Cancer Institute, Stanford University, Palo Alto, California. .
Phipps AI; Epidemiology Department, University of Washington, Seattle, Washington. Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Baron JA; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Buchanan DD; Colorectal Oncogenomics Group, Genetic Epidemiology Laboratory, Centre for Epidemiology and Biostatistics and Department of Pathology, The University of Melbourne, Victoria, Australia.
Ahnen DJ; University of Colorado School of Medicine, Denver, Colorado.
Cohen SA; Division of Oncology, University of Washington, Seattle, Washington. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Lindor NM; Clinical and Molecular Genetics, Department of Health Science Research, Mayo Clinic Arizona, Scottsdale, Arizona.
Newcomb PA; Epidemiology Department, University of Washington, Seattle, Washington. Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Rosty C; Envoi Pathology, Brisbane, QLD, The University of Melbourne, Melbourne, Australia. Department of Pathology, The University of Melbourne, Melbourne, Australia.
Haile RW; Stanford Cancer Institute, Stanford University, Palo Alto, California.
Laird PW; Center for Epigenomics, Van Andel Research Institute, Grand Rapids, Michigan.
Weisenberger DJ; Department of Biochemistry and Molecular Biology, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California.
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Źródło :
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2016 Jan; Vol. 25 (1), pp. 68-75. Date of Electronic Publication: 2015 Oct 28.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
DNA Methylation*
Microsatellite Instability*
Adaptor Proteins, Signal Transducing/*genetics
Colorectal Neoplasms/*genetics
Colorectal Neoplasms/*pathology
CpG Islands/*genetics
Nuclear Proteins/*genetics
Promoter Regions, Genetic/*genetics
Aged ; Biomarkers, Tumor ; Case-Control Studies ; Colorectal Neoplasms/epidemiology ; Female ; Follow-Up Studies ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Middle Aged ; MutL Protein Homolog 1 ; Mutation/genetics ; Neoplasm Staging ; Prognosis ; Risk Factors ; Survival Rate
Czasopismo naukowe
Tytuł :
Cancer emerging from the recurrence of sessile serrated adenoma/polyp resected endoscopically 5 years ago.
Autorzy :
Chino A; Digestive of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo .
Nagayama S; Digestive of Surgery Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo.
Ishikawa H; Digestive of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo.
Morishige K; Digestive of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo.
Kishihara T; Digestive of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo.
Arai M; Clinical Genetic Oncology Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo.
Sugiura Y; Pathology Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
Motoi N; Pathology Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
Yamamoto N; Pathology Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
Tamegai Y; Digestive of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo.
Igarashi M; Digestive of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo.
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Źródło :
Japanese journal of clinical oncology [Jpn J Clin Oncol] 2016 Jan; Vol. 46 (1), pp. 89-95. Date of Electronic Publication: 2015 Nov 03.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Colonoscopy*
Adaptor Proteins, Signal Transducing/*analysis
Adenocarcinoma/*diagnosis
Adenoma/*surgery
Colonic Neoplasms/*diagnosis
Colonic Neoplasms/*surgery
Colonic Polyps/*surgery
Neoplasm Recurrence, Local/*diagnosis
Nuclear Proteins/*analysis
Adenocarcinoma/chemistry ; Adenocarcinoma/pathology ; Adenocarcinoma/surgery ; Adenoma/chemistry ; Aged ; Colonic Neoplasms/chemistry ; Colonic Neoplasms/pathology ; Colonic Polyps/chemistry ; Colonic Polyps/pathology ; Female ; Humans ; Hyperplasia ; Immunohistochemistry ; MutL Protein Homolog 1 ; Neoplasm Recurrence, Local/chemistry
Czasopismo naukowe
Tytuł :
Distinctive Genetic Profile With IDH1, TP53, and MLH1 Mutations in a Radiation-Induced Anaplastic Astrocytoma.
Autorzy :
Mascelli S; Istituto Giannina Gaslini, via G. Gaslini 5, 16147 Genoa, Italy.
Nozza P; Istituto Giannina Gaslini, via G. Gaslini 5, 16147 Genoa, Italy.
Sak K; Asper Biotechnology, Ltd., Tartu, Estonia.
Joost K; Asper Biotechnology, Ltd., Tartu, Estonia.
Cama A; Istituto Giannina Gaslini, via G. Gaslini 5, 16147 Genoa, Italy.
Capra V; Istituto Giannina Gaslini, via G. Gaslini 5, 16147 Genoa, Italy.
Garrè ML; Istituto Giannina Gaslini, via G. Gaslini 5, 16147 Genoa, Italy.
Raso A; Istituto Giannina Gaslini, via G. Gaslini 5, 16147 Genoa, Italy.
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Źródło :
Pediatric blood & cancer [Pediatr Blood Cancer] 2016 Jan; Vol. 63 (1), pp. 179. Date of Electronic Publication: 2015 Jul 16.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Adaptor Proteins, Signal Transducing/*genetics
Astrocytoma/*genetics
Genes, p53/*genetics
Isocitrate Dehydrogenase/*genetics
Neoplasms, Radiation-Induced/*genetics
Nuclear Proteins/*genetics
Humans ; MutL Protein Homolog 1
Raport
Tytuł :
Interdependence of DNA mismatch repair proteins MLH1 and MSH2 in apoptosis in human colorectal carcinoma cell lines.
Autorzy :
Hassen S; Department of Biology, College of Arts, Letters and Sciences, University of Arkansas at Little Rock, 2801 S. University Avenue, Little Rock, AR, 72204, USA.
Ali AA; Department of Biology, College of Arts, Letters and Sciences, University of Arkansas at Little Rock, 2801 S. University Avenue, Little Rock, AR, 72204, USA.; CATX Inc., Gladwyne, PA, 19035, USA.
Kilaparty SP; Department of Biology, College of Arts, Letters and Sciences, University of Arkansas at Little Rock, 2801 S. University Avenue, Little Rock, AR, 72204, USA.
Al-Anbaky QA; Department of Biology, College of Arts, Letters and Sciences, University of Arkansas at Little Rock, 2801 S. University Avenue, Little Rock, AR, 72204, USA.
Majeed W; Center for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock, Little Rock, AR, 72204, USA.
Boman BM; Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Kimmel Cancer Center, Philadelphia, PA, 19107, USA.; Center for Translational Cancer Research, University of Delaware, Helen F Graham Cancer Center, Newark, DE, 19713, USA.; CATX Inc., Gladwyne, PA, 19035, USA.
Fields JZ; CATX Inc., Gladwyne, PA, 19035, USA.
Ali N; Department of Biology, College of Arts, Letters and Sciences, University of Arkansas at Little Rock, 2801 S. University Avenue, Little Rock, AR, 72204, USA. .
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Źródło :
Molecular and cellular biochemistry [Mol Cell Biochem] 2016 Jan; Vol. 412 (1-2), pp. 297-305. Date of Electronic Publication: 2016 Jan 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
DNA Mismatch Repair*
Adaptor Proteins, Signal Transducing/*physiology
Apoptosis/*physiology
Colorectal Neoplasms/*pathology
MutS Homolog 2 Protein/*physiology
Nuclear Proteins/*physiology
Antineoplastic Agents/therapeutic use ; Caspase 3/metabolism ; Colorectal Neoplasms/drug therapy ; Etoposide/therapeutic use ; Humans ; MutL Protein Homolog 1 ; Proteolysis
Czasopismo naukowe
Tytuł :
Combined Microsatellite Instability, MLH1 Methylation Analysis, and Immunohistochemistry for Lynch Syndrome Screening in Endometrial Cancers From GOG210: An NRG Oncology and Gynecologic Oncology Group Study.
Autorzy :
Goodfellow PJ; Paul J. Goodfellow, Caroline C. Billingsley, David E. Cohn, Heather Hampel, Alexis S. Chassen, Luke V. Simmons, and Floor Backes, Ohio State University; Nilsa Ramirez, Research Institute at Nationwide Children's Hospital, Columbus, OH; Heather A. Lankes and Shamshad Ali, NRG Oncology Statistics and Data Management Center; Shashikant B. Lele, Roswell Park Cancer Institute, Buffalo; Michael L. Pearl, Stony Brook University Hospital, Stony Brook, NY; Russell J. Broaddus, University of Texas MD Anderson Cancer Center, Houston, TX; Colin C. Pritchard, University of Washington, Seattle, WA; Amy P. Schmidt, Feng Gao, Matthew A. Powell, and David Mutch, Washington University School of Medicine, St Louis, MO; Louise A. Brinton, National Cancer Institute, Washington, DC; Lisa M. Landrum, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Melissa A. Geller, University of Minnesota, Minneapolis, MN; Paul A. DiSilvestro, Women and Infants Hospital of Rhode Island, Providence, RI; and Richard J. Zaino, Penn State Milton S. Hershey Medical Center, Hershey, PA. .
Billingsley CC; Paul J. Goodfellow, Caroline C. Billingsley, David E. Cohn, Heather Hampel, Alexis S. Chassen, Luke V. Simmons, and Floor Backes, Ohio State University; Nilsa Ramirez, Research Institute at Nationwide Children's Hospital, Columbus, OH; Heather A. Lankes and Shamshad Ali, NRG Oncology Statistics and Data Management Center; Shashikant B. Lele, Roswell Park Cancer Institute, Buffalo; Michael L. Pearl, Stony Brook University Hospital, Stony Brook, NY; Russell J. Broaddus, University of Texas MD Anderson Cancer Center, Houston, TX; Colin C. Pritchard, University of Washington, Seattle, WA; Amy P. Schmidt, Feng Gao, Matthew A. Powell, and David Mutch, Washington University School of Medicine, St Louis, MO; Louise A. Brinton, National Cancer Institute, Washington, DC; Lisa M. Landrum, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Melissa A. Geller, University of Minnesota, Minneapolis, MN; Paul A. DiSilvestro, Women and Infants Hospital of Rhode Island, Providence, RI; and Richard J. Zaino, Penn State Milton S. Hershey Medical Center, Hershey, PA.
Lankes HA; Paul J. Goodfellow, Caroline C. Billingsley, David E. Cohn, Heather Hampel, Alexis S. Chassen, Luke V. Simmons, and Floor Backes, Ohio State University; Nilsa Ramirez, Research Institute at Nationwide Children's Hospital, Columbus, OH; Heather A. Lankes and Shamshad Ali, NRG Oncology Statistics and Data Management Center; Shashikant B. Lele, Roswell Park Cancer Institute, Buffalo; Michael L. Pearl, Stony Brook University Hospital, Stony Brook, NY; Russell J. Broaddus, University of Texas MD Anderson Cancer Center, Houston, TX; Colin C. Pritchard, University of Washington, Seattle, WA; Amy P. Schmidt, Feng Gao, Matthew A. Powell, and David Mutch, Washington University School of Medicine, St Louis, MO; Louise A. Brinton, National Cancer Institute, Washington, DC; Lisa M. Landrum, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Melissa A. Geller, University of Minnesota, Minneapolis, MN; Paul A. DiSilvestro, Women and Infants Hospital of Rhode Island, Providence, RI; and Richard J. Zaino, Penn State Milton S. Hershey Medical Center, Hershey, PA.
Ali S; Paul J. Goodfellow, Caroline C. Billingsley, David E. Cohn, Heather Hampel, Alexis S. Chassen, Luke V. Simmons, and Floor Backes, Ohio State University; Nilsa Ramirez, Research Institute at Nationwide Children's Hospital, Columbus, OH; Heather A. Lankes and Shamshad Ali, NRG Oncology Statistics and Data Management Center; Shashikant B. Lele, Roswell Park Cancer Institute, Buffalo; Michael L. Pearl, Stony Brook University Hospital, Stony Brook, NY; Russell J. Broaddus, University of Texas MD Anderson Cancer Center, Houston, TX; Colin C. Pritchard, University of Washington, Seattle, WA; Amy P. Schmidt, Feng Gao, Matthew A. Powell, and David Mutch, Washington University School of Medicine, St Louis, MO; Louise A. Brinton, National Cancer Institute, Washington, DC; Lisa M. Landrum, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Melissa A. Geller, University of Minnesota, Minneapolis, MN; Paul A. DiSilvestro, Women and Infants Hospital of Rhode Island, Providence, RI; and Richard J. Zaino, Penn State Milton S. Hershey Medical Center, Hershey, PA.
Cohn DE; Paul J. Goodfellow, Caroline C. Billingsley, David E. Cohn, Heather Hampel, Alexis S. Chassen, Luke V. Simmons, and Floor Backes, Ohio State University; Nilsa Ramirez, Research Institute at Nationwide Children's Hospital, Columbus, OH; Heather A. Lankes and Shamshad Ali, NRG Oncology Statistics and Data Management Center; Shashikant B. Lele, Roswell Park Cancer Institute, Buffalo; Michael L. Pearl, Stony Brook University Hospital, Stony Brook, NY; Russell J. Broaddus, University of Texas MD Anderson Cancer Center, Houston, TX; Colin C. Pritchard, University of Washington, Seattle, WA; Amy P. Schmidt, Feng Gao, Matthew A. Powell, and David Mutch, Washington University School of Medicine, St Louis, MO; Louise A. Brinton, National Cancer Institute, Washington, DC; Lisa M. Landrum, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Melissa A. Geller, University of Minnesota, Minneapolis, MN; Paul A. DiSilvestro, Women and Infants Hospital of Rhode Island, Providence, RI; and Richard J. Zaino, Penn State Milton S. Hershey Medical Center, Hershey, PA.
Broaddus RJ; Paul J. Goodfellow, Caroline C. Billingsley, David E. Cohn, Heather Hampel, Alexis S. Chassen, Luke V. Simmons, and Floor Backes, Ohio State University; Nilsa Ramirez, Research Institute at Nationwide Children's Hospital, Columbus, OH; Heather A. Lankes and Shamshad Ali, NRG Oncology Statistics and Data Management Center; Shashikant B. Lele, Roswell Park Cancer Institute, Buffalo; Michael L. Pearl, Stony Brook University Hospital, Stony Brook, NY; Russell J. Broaddus, University of Texas MD Anderson Cancer Center, Houston, TX; Colin C. Pritchard, University of Washington, Seattle, WA; Amy P. Schmidt, Feng Gao, Matthew A. Powell, and David Mutch, Washington University School of Medicine, St Louis, MO; Louise A. Brinton, National Cancer Institute, Washington, DC; Lisa M. Landrum, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Melissa A. Geller, University of Minnesota, Minneapolis, MN; Paul A. DiSilvestro, Women and Infants Hospital of Rhode Island, Providence, RI; and Richard J. Zaino, Penn State Milton S. Hershey Medical Center, Hershey, PA.
Ramirez N; Paul J. Goodfellow, Caroline C. Billingsley, David E. Cohn, Heather Hampel, Alexis S. Chassen, Luke V. Simmons, and Floor Backes, Ohio State University; Nilsa Ramirez, Research Institute at Nationwide Children's Hospital, Columbus, OH; Heather A. Lankes and Shamshad Ali, NRG Oncology Statistics and Data Management Center; Shashikant B. Lele, Roswell Park Cancer Institute, Buffalo; Michael L. Pearl, Stony Brook University Hospital, Stony Brook, NY; Russell J. Broaddus, University of Texas MD Anderson Cancer Center, Houston, TX; Colin C. Pritchard, University of Washington, Seattle, WA; Amy P. Schmidt, Feng Gao, Matthew A. Powell, and David Mutch, Washington University School of Medicine, St Louis, MO; Louise A. Brinton, National Cancer Institute, Washington, DC; Lisa M. Landrum, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Melissa A. Geller, University of Minnesota, Minneapolis, MN; Paul A. DiSilvestro, Women and Infants Hospital of Rhode Island, Providence, RI; and Richard J. Zaino, Penn State Milton S. Hershey Medical Center, Hershey, PA.
Pritchard CC; Paul J. Goodfellow, Caroline C. Billingsley, David E. Cohn, Heather Hampel, Alexis S. Chassen, Luke V. Simmons, and Floor Backes, Ohio State University; Nilsa Ramirez, Research Institute at Nationwide Children's Hospital, Columbus, OH; Heather A. Lankes and Shamshad Ali, NRG Oncology Statistics and Data Management Center; Shashikant B. Lele, Roswell Park Cancer Institute, Buffalo; Michael L. Pearl, Stony Brook University Hospital, Stony Brook, NY; Russell J. Broaddus, University of Texas MD Anderson Cancer Center, Houston, TX; Colin C. Pritchard, University of Washington, Seattle, WA; Amy P. Schmidt, Feng Gao, Matthew A. Powell, and David Mutch, Washington University School of Medicine, St Louis, MO; Louise A. Brinton, National Cancer Institute, Washington, DC; Lisa M. Landrum, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Melissa A. Geller, University of Minnesota, Minneapolis, MN; Paul A. DiSilvestro, Women and Infants Hospital of Rhode Island, Providence, RI; and Richard J. Zaino, Penn State Milton S. Hershey Medical Center, Hershey, PA.
Hampel H; Paul J. Goodfellow, Caroline C. Billingsley, David E. Cohn, Heather Hampel, Alexis S. Chassen, Luke V. Simmons, and Floor Backes, Ohio State University; Nilsa Ramirez, Research Institute at Nationwide Children's Hospital, Columbus, OH; Heather A. Lankes and Shamshad Ali, NRG Oncology Statistics and Data Management Center; Shashikant B. Lele, Roswell Park Cancer Institute, Buffalo; Michael L. Pearl, Stony Brook University Hospital, Stony Brook, NY; Russell J. Broaddus, University of Texas MD Anderson Cancer Center, Houston, TX; Colin C. Pritchard, University of Washington, Seattle, WA; Amy P. Schmidt, Feng Gao, Matthew A. Powell, and David Mutch, Washington University School of Medicine, St Louis, MO; Louise A. Brinton, National Cancer Institute, Washington, DC; Lisa M. Landrum, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Melissa A. Geller, University of Minnesota, Minneapolis, MN; Paul A. DiSilvestro, Women and Infants Hospital of Rhode Island, Providence, RI; and Richard J. Zaino, Penn State Milton S. Hershey Medical Center, Hershey, PA.
Chassen AS; Paul J. Goodfellow, Caroline C. Billingsley, David E. Cohn, Heather Hampel, Alexis S. Chassen, Luke V. Simmons, and Floor Backes, Ohio State University; Nilsa Ramirez, Research Institute at Nationwide Children's Hospital, Columbus, OH; Heather A. Lankes and Shamshad Ali, NRG Oncology Statistics and Data Management Center; Shashikant B. Lele, Roswell Park Cancer Institute, Buffalo; Michael L. Pearl, Stony Brook University Hospital, Stony Brook, NY; Russell J. Broaddus, University of Texas MD Anderson Cancer Center, Houston, TX; Colin C. Pritchard, University of Washington, Seattle, WA; Amy P. Schmidt, Feng Gao, Matthew A. Powell, and David Mutch, Washington University School of Medicine, St Louis, MO; Louise A. Brinton, National Cancer Institute, Washington, DC; Lisa M. Landrum, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Melissa A. Geller, University of Minnesota, Minneapolis, MN; Paul A. DiSilvestro, Women and Infants Hospital of Rhode Island, Providence, RI; and Richard J. Zaino, Penn State Milton S. Hershey Medical Center, Hershey, PA.
Simmons LV; Paul J. Goodfellow, Caroline C. Billingsley, David E. Cohn, Heather Hampel, Alexis S. Chassen, Luke V. Simmons, and Floor Backes, Ohio State University; Nilsa Ramirez, Research Institute at Nationwide Children's Hospital, Columbus, OH; Heather A. Lankes and Shamshad Ali, NRG Oncology Statistics and Data Management Center; Shashikant B. Lele, Roswell Park Cancer Institute, Buffalo; Michael L. Pearl, Stony Brook University Hospital, Stony Brook, NY; Russell J. Broaddus, University of Texas MD Anderson Cancer Center, Houston, TX; Colin C. Pritchard, University of Washington, Seattle, WA; Amy P. Schmidt, Feng Gao, Matthew A. Powell, and David Mutch, Washington University School of Medicine, St Louis, MO; Louise A. Brinton, National Cancer Institute, Washington, DC; Lisa M. Landrum, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Melissa A. Geller, University of Minnesota, Minneapolis, MN; Paul A. DiSilvestro, Women and Infants Hospital of Rhode Island, Providence, RI; and Richard J. Zaino, Penn State Milton S. Hershey Medical Center, Hershey, PA.
Schmidt AP; Paul J. Goodfellow, Caroline C. Billingsley, David E. Cohn, Heather Hampel, Alexis S. Chassen, Luke V. Simmons, and Floor Backes, Ohio State University; Nilsa Ramirez, Research Institute at Nationwide Children's Hospital, Columbus, OH; Heather A. Lankes and Shamshad Ali, NRG Oncology Statistics and Data Management Center; Shashikant B. Lele, Roswell Park Cancer Institute, Buffalo; Michael L. Pearl, Stony Brook University Hospital, Stony Brook, NY; Russell J. Broaddus, University of Texas MD Anderson Cancer Center, Houston, TX; Colin C. Pritchard, University of Washington, Seattle, WA; Amy P. Schmidt, Feng Gao, Matthew A. Powell, and David Mutch, Washington University School of Medicine, St Louis, MO; Louise A. Brinton, National Cancer Institute, Washington, DC; Lisa M. Landrum, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Melissa A. Geller, University of Minnesota, Minneapolis, MN; Paul A. DiSilvestro, Women and Infants Hospital of Rhode Island, Providence, RI; and Richard J. Zaino, Penn State Milton S. Hershey Medical Center, Hershey, PA.
Gao F; Paul J. Goodfellow, Caroline C. Billingsley, David E. Cohn, Heather Hampel, Alexis S. Chassen, Luke V. Simmons, and Floor Backes, Ohio State University; Nilsa Ramirez, Research Institute at Nationwide Children's Hospital, Columbus, OH; Heather A. Lankes and Shamshad Ali, NRG Oncology Statistics and Data Management Center; Shashikant B. Lele, Roswell Park Cancer Institute, Buffalo; Michael L. Pearl, Stony Brook University Hospital, Stony Brook, NY; Russell J. Broaddus, University of Texas MD Anderson Cancer Center, Houston, TX; Colin C. Pritchard, University of Washington, Seattle, WA; Amy P. Schmidt, Feng Gao, Matthew A. Powell, and David Mutch, Washington University School of Medicine, St Louis, MO; Louise A. Brinton, National Cancer Institute, Washington, DC; Lisa M. Landrum, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Melissa A. Geller, University of Minnesota, Minneapolis, MN; Paul A. DiSilvestro, Women and Infants Hospital of Rhode Island, Providence, RI; and Richard J. Zaino, Penn State Milton S. Hershey Medical Center, Hershey, PA.
Brinton LA; Paul J. Goodfellow, Caroline C. Billingsley, David E. Cohn, Heather Hampel, Alexis S. Chassen, Luke V. Simmons, and Floor Backes, Ohio State University; Nilsa Ramirez, Research Institute at Nationwide Children's Hospital, Columbus, OH; Heather A. Lankes and Shamshad Ali, NRG Oncology Statistics and Data Management Center; Shashikant B. Lele, Roswell Park Cancer Institute, Buffalo; Michael L. Pearl, Stony Brook University Hospital, Stony Brook, NY; Russell J. Broaddus, University of Texas MD Anderson Cancer Center, Houston, TX; Colin C. Pritchard, University of Washington, Seattle, WA; Amy P. Schmidt, Feng Gao, Matthew A. Powell, and David Mutch, Washington University School of Medicine, St Louis, MO; Louise A. Brinton, National Cancer Institute, Washington, DC; Lisa M. Landrum, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Melissa A. Geller, University of Minnesota, Minneapolis, MN; Paul A. DiSilvestro, Women and Infants Hospital of Rhode Island, Providence, RI; and Richard J. Zaino, Penn State Milton S. Hershey Medical Center, Hershey, PA.
Backes F; Paul J. Goodfellow, Caroline C. Billingsley, David E. Cohn, Heather Hampel, Alexis S. Chassen, Luke V. Simmons, and Floor Backes, Ohio State University; Nilsa Ramirez, Research Institute at Nationwide Children's Hospital, Columbus, OH; Heather A. Lankes and Shamshad Ali, NRG Oncology Statistics and Data Management Center; Shashikant B. Lele, Roswell Park Cancer Institute, Buffalo; Michael L. Pearl, Stony Brook University Hospital, Stony Brook, NY; Russell J. Broaddus, University of Texas MD Anderson Cancer Center, Houston, TX; Colin C. Pritchard, University of Washington, Seattle, WA; Amy P. Schmidt, Feng Gao, Matthew A. Powell, and David Mutch, Washington University School of Medicine, St Louis, MO; Louise A. Brinton, National Cancer Institute, Washington, DC; Lisa M. Landrum, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Melissa A. Geller, University of Minnesota, Minneapolis, MN; Paul A. DiSilvestro, Women and Infants Hospital of Rhode Island, Providence, RI; and Richard J. Zaino, Penn State Milton S. Hershey Medical Center, Hershey, PA.
Landrum LM; Paul J. Goodfellow, Caroline C. Billingsley, David E. Cohn, Heather Hampel, Alexis S. Chassen, Luke V. Simmons, and Floor Backes, Ohio State University; Nilsa Ramirez, Research Institute at Nationwide Children's Hospital, Columbus, OH; Heather A. Lankes and Shamshad Ali, NRG Oncology Statistics and Data Management Center; Shashikant B. Lele, Roswell Park Cancer Institute, Buffalo; Michael L. Pearl, Stony Brook University Hospital, Stony Brook, NY; Russell J. Broaddus, University of Texas MD Anderson Cancer Center, Houston, TX; Colin C. Pritchard, University of Washington, Seattle, WA; Amy P. Schmidt, Feng Gao, Matthew A. Powell, and David Mutch, Washington University School of Medicine, St Louis, MO; Louise A. Brinton, National Cancer Institute, Washington, DC; Lisa M. Landrum, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Melissa A. Geller, University of Minnesota, Minneapolis, MN; Paul A. DiSilvestro, Women and Infants Hospital of Rhode Island, Providence, RI; and Richard J. Zaino, Penn State Milton S. Hershey Medical Center, Hershey, PA.
Geller MA; Paul J. Goodfellow, Caroline C. Billingsley, David E. Cohn, Heather Hampel, Alexis S. Chassen, Luke V. Simmons, and Floor Backes, Ohio State University; Nilsa Ramirez, Research Institute at Nationwide Children's Hospital, Columbus, OH; Heather A. Lankes and Shamshad Ali, NRG Oncology Statistics and Data Management Center; Shashikant B. Lele, Roswell Park Cancer Institute, Buffalo; Michael L. Pearl, Stony Brook University Hospital, Stony Brook, NY; Russell J. Broaddus, University of Texas MD Anderson Cancer Center, Houston, TX; Colin C. Pritchard, University of Washington, Seattle, WA; Amy P. Schmidt, Feng Gao, Matthew A. Powell, and David Mutch, Washington University School of Medicine, St Louis, MO; Louise A. Brinton, National Cancer Institute, Washington, DC; Lisa M. Landrum, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Melissa A. Geller, University of Minnesota, Minneapolis, MN; Paul A. DiSilvestro, Women and Infants Hospital of Rhode Island, Providence, RI; and Richard J. Zaino, Penn State Milton S. Hershey Medical Center, Hershey, PA.
DiSilvestro PA; Paul J. Goodfellow, Caroline C. Billingsley, David E. Cohn, Heather Hampel, Alexis S. Chassen, Luke V. Simmons, and Floor Backes, Ohio State University; Nilsa Ramirez, Research Institute at Nationwide Children's Hospital, Columbus, OH; Heather A. Lankes and Shamshad Ali, NRG Oncology Statistics and Data Management Center; Shashikant B. Lele, Roswell Park Cancer Institute, Buffalo; Michael L. Pearl, Stony Brook University Hospital, Stony Brook, NY; Russell J. Broaddus, University of Texas MD Anderson Cancer Center, Houston, TX; Colin C. Pritchard, University of Washington, Seattle, WA; Amy P. Schmidt, Feng Gao, Matthew A. Powell, and David Mutch, Washington University School of Medicine, St Louis, MO; Louise A. Brinton, National Cancer Institute, Washington, DC; Lisa M. Landrum, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Melissa A. Geller, University of Minnesota, Minneapolis, MN; Paul A. DiSilvestro, Women and Infants Hospital of Rhode Island, Providence, RI; and Richard J. Zaino, Penn State Milton S. Hershey Medical Center, Hershey, PA.
Pearl ML; Paul J. Goodfellow, Caroline C. Billingsley, David E. Cohn, Heather Hampel, Alexis S. Chassen, Luke V. Simmons, and Floor Backes, Ohio State University; Nilsa Ramirez, Research Institute at Nationwide Children's Hospital, Columbus, OH; Heather A. Lankes and Shamshad Ali, NRG Oncology Statistics and Data Management Center; Shashikant B. Lele, Roswell Park Cancer Institute, Buffalo; Michael L. Pearl, Stony Brook University Hospital, Stony Brook, NY; Russell J. Broaddus, University of Texas MD Anderson Cancer Center, Houston, TX; Colin C. Pritchard, University of Washington, Seattle, WA; Amy P. Schmidt, Feng Gao, Matthew A. Powell, and David Mutch, Washington University School of Medicine, St Louis, MO; Louise A. Brinton, National Cancer Institute, Washington, DC; Lisa M. Landrum, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Melissa A. Geller, University of Minnesota, Minneapolis, MN; Paul A. DiSilvestro, Women and Infants Hospital of Rhode Island, Providence, RI; and Richard J. Zaino, Penn State Milton S. Hershey Medical Center, Hershey, PA.
Lele SB; Paul J. Goodfellow, Caroline C. Billingsley, David E. Cohn, Heather Hampel, Alexis S. Chassen, Luke V. Simmons, and Floor Backes, Ohio State University; Nilsa Ramirez, Research Institute at Nationwide Children's Hospital, Columbus, OH; Heather A. Lankes and Shamshad Ali, NRG Oncology Statistics and Data Management Center; Shashikant B. Lele, Roswell Park Cancer Institute, Buffalo; Michael L. Pearl, Stony Brook University Hospital, Stony Brook, NY; Russell J. Broaddus, University of Texas MD Anderson Cancer Center, Houston, TX; Colin C. Pritchard, University of Washington, Seattle, WA; Amy P. Schmidt, Feng Gao, Matthew A. Powell, and David Mutch, Washington University School of Medicine, St Louis, MO; Louise A. Brinton, National Cancer Institute, Washington, DC; Lisa M. Landrum, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Melissa A. Geller, University of Minnesota, Minneapolis, MN; Paul A. DiSilvestro, Women and Infants Hospital of Rhode Island, Providence, RI; and Richard J. Zaino, Penn State Milton S. Hershey Medical Center, Hershey, PA.
Powell MA; Paul J. Goodfellow, Caroline C. Billingsley, David E. Cohn, Heather Hampel, Alexis S. Chassen, Luke V. Simmons, and Floor Backes, Ohio State University; Nilsa Ramirez, Research Institute at Nationwide Children's Hospital, Columbus, OH; Heather A. Lankes and Shamshad Ali, NRG Oncology Statistics and Data Management Center; Shashikant B. Lele, Roswell Park Cancer Institute, Buffalo; Michael L. Pearl, Stony Brook University Hospital, Stony Brook, NY; Russell J. Broaddus, University of Texas MD Anderson Cancer Center, Houston, TX; Colin C. Pritchard, University of Washington, Seattle, WA; Amy P. Schmidt, Feng Gao, Matthew A. Powell, and David Mutch, Washington University School of Medicine, St Louis, MO; Louise A. Brinton, National Cancer Institute, Washington, DC; Lisa M. Landrum, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Melissa A. Geller, University of Minnesota, Minneapolis, MN; Paul A. DiSilvestro, Women and Infants Hospital of Rhode Island, Providence, RI; and Richard J. Zaino, Penn State Milton S. Hershey Medical Center, Hershey, PA.
Zaino RJ; Paul J. Goodfellow, Caroline C. Billingsley, David E. Cohn, Heather Hampel, Alexis S. Chassen, Luke V. Simmons, and Floor Backes, Ohio State University; Nilsa Ramirez, Research Institute at Nationwide Children's Hospital, Columbus, OH; Heather A. Lankes and Shamshad Ali, NRG Oncology Statistics and Data Management Center; Shashikant B. Lele, Roswell Park Cancer Institute, Buffalo; Michael L. Pearl, Stony Brook University Hospital, Stony Brook, NY; Russell J. Broaddus, University of Texas MD Anderson Cancer Center, Houston, TX; Colin C. Pritchard, University of Washington, Seattle, WA; Amy P. Schmidt, Feng Gao, Matthew A. Powell, and David Mutch, Washington University School of Medicine, St Louis, MO; Louise A. Brinton, National Cancer Institute, Washington, DC; Lisa M. Landrum, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Melissa A. Geller, University of Minnesota, Minneapolis, MN; Paul A. DiSilvestro, Women and Infants Hospital of Rhode Island, Providence, RI; and Richard J. Zaino, Penn State Milton S. Hershey Medical Center, Hershey, PA.
Mutch D; Paul J. Goodfellow, Caroline C. Billingsley, David E. Cohn, Heather Hampel, Alexis S. Chassen, Luke V. Simmons, and Floor Backes, Ohio State University; Nilsa Ramirez, Research Institute at Nationwide Children's Hospital, Columbus, OH; Heather A. Lankes and Shamshad Ali, NRG Oncology Statistics and Data Management Center; Shashikant B. Lele, Roswell Park Cancer Institute, Buffalo; Michael L. Pearl, Stony Brook University Hospital, Stony Brook, NY; Russell J. Broaddus, University of Texas MD Anderson Cancer Center, Houston, TX; Colin C. Pritchard, University of Washington, Seattle, WA; Amy P. Schmidt, Feng Gao, Matthew A. Powell, and David Mutch, Washington University School of Medicine, St Louis, MO; Louise A. Brinton, National Cancer Institute, Washington, DC; Lisa M. Landrum, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Melissa A. Geller, University of Minnesota, Minneapolis, MN; Paul A. DiSilvestro, Women and Infants Hospital of Rhode Island, Providence, RI; and Richard J. Zaino, Penn State Milton S. Hershey Medical Center, Hershey, PA.
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Źródło :
Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2015 Dec 20; Vol. 33 (36), pp. 4301-8. Date of Electronic Publication: 2015 Nov 09.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
DNA Methylation*
DNA Mismatch Repair*/genetics
Genetic Testing*/methods
Germ-Line Mutation*
Microsatellite Instability*
Adaptor Proteins, Signal Transducing/*genetics
Colorectal Neoplasms, Hereditary Nonpolyposis/*diagnosis
Colorectal Neoplasms, Hereditary Nonpolyposis/*genetics
Early Detection of Cancer/*methods
Endometrial Neoplasms/*genetics
Endometrial Neoplasms/*pathology
Nuclear Proteins/*genetics
Population Surveillance/*methods
Adenosine Triphosphatases/genetics ; Adult ; Age Factors ; Aged ; Colorectal Neoplasms, Hereditary Nonpolyposis/pathology ; Colorectal Neoplasms, Hereditary Nonpolyposis/prevention & control ; DNA Repair Enzymes/genetics ; DNA-Binding Proteins/genetics ; Early Detection of Cancer/standards ; Endometrial Neoplasms/chemistry ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry ; Middle Aged ; Mismatch Repair Endonuclease PMS2 ; MutL Protein Homolog 1 ; MutS Homolog 2 Protein/genetics ; Pedigree ; Predictive Value of Tests
Czasopismo naukowe
Tytuł :
Identification of germline genetic mutations in patients with pancreatic cancer.
Autorzy :
Salo-Mullen EE; Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, New York.
O'Reilly EM; Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, New York.
Kelsen DP; Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, New York.
Ashraf AM; Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, New York.
Lowery MA; Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, New York.
Yu KH; Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, New York.
Reidy DL; Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, New York.
Epstein AS; Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, New York.
Lincoln A; Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, New York.
Saldia A; Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, New York.
Jacobs LM; Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, New York.
Rau-Murthy R; Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, New York.
Zhang L; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Kurtz RC; Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, New York.
Saltz L; Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, New York.
Offit K; Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, New York.
Robson ME; Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, New York.
Stadler ZK; Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, New York.
Pokaż więcej
Źródło :
Cancer [Cancer] 2015 Dec 15; Vol. 121 (24), pp. 4382-8. Date of Electronic Publication: 2015 Oct 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, BRCA1*
Genes, BRCA2*
Genes, p16*
Germ-Line Mutation*
Adenocarcinoma/*genetics
DNA Mismatch Repair/*genetics
Nuclear Proteins/*genetics
Pancreatic Neoplasms/*genetics
Tumor Suppressor Proteins/*genetics
Adaptor Proteins, Signal Transducing/genetics ; Adenosine Triphosphatases/genetics ; Adult ; Aged ; Aged, 80 and over ; Colorectal Neoplasms, Hereditary Nonpolyposis/genetics ; DNA Repair Enzymes/genetics ; DNA-Binding Proteins/genetics ; Fanconi Anemia Complementation Group N Protein ; Female ; Hereditary Breast and Ovarian Cancer Syndrome/genetics ; Humans ; Jews/genetics ; Male ; Middle Aged ; Mismatch Repair Endonuclease PMS2 ; MutL Protein Homolog 1 ; MutS Homolog 2 Protein/genetics ; Neoplastic Syndromes, Hereditary/genetics
Czasopismo naukowe

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