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Wyszukujesz frazę ""MutL Protein Homolog 1"" wg kryterium: Temat


Tytuł:
Classification of MLH1 Missense VUS Using Protein Structure-Based Deep Learning-Ramachandran Plot-Molecular Dynamics Simulations Method.
Autorzy:
Tam B; Ministry of Education Frontiers Science Center for Precision Oncology, Faculty of Health Sciences, University of Macau, Macau SAR, China.; Cancer Centre, Faculty of Health Sciences, University of Macau, Macau SAR, China.; Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Qin Z; Ministry of Education Frontiers Science Center for Precision Oncology, Faculty of Health Sciences, University of Macau, Macau SAR, China.; Cancer Centre, Faculty of Health Sciences, University of Macau, Macau SAR, China.; Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Zhao B; Ministry of Education Frontiers Science Center for Precision Oncology, Faculty of Health Sciences, University of Macau, Macau SAR, China.; Cancer Centre, Faculty of Health Sciences, University of Macau, Macau SAR, China.; Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Sinha S; Ministry of Education Frontiers Science Center for Precision Oncology, Faculty of Health Sciences, University of Macau, Macau SAR, China.; Cancer Centre, Faculty of Health Sciences, University of Macau, Macau SAR, China.; Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Lei CL; Ministry of Education Frontiers Science Center for Precision Oncology, Faculty of Health Sciences, University of Macau, Macau SAR, China.; Cancer Centre, Faculty of Health Sciences, University of Macau, Macau SAR, China.; Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Wang SM; Ministry of Education Frontiers Science Center for Precision Oncology, Faculty of Health Sciences, University of Macau, Macau SAR, China.; Cancer Centre, Faculty of Health Sciences, University of Macau, Macau SAR, China.; Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 10; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 10.
Typ publikacji:
Journal Article
MeSH Terms:
Colorectal Neoplasms, Hereditary Nonpolyposis*/genetics
Deep Learning*
MutL Protein Homolog 1*/genetics
Humans ; Databases, Factual ; DNA Mismatch Repair ; Molecular Dynamics Simulation
Czasopismo naukowe
Tytuł:
Association between colorectal cancer, the frequency of Bacteroides fragilis, and the level of mismatch repair genes expression in the biopsy samples of Iranian patients.
Autorzy:
Nazarinejad N; Department of Microbiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
Hajikhani B; Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Vaezi AA; Department of Internal Medicine, Alborz University of Medical Sciences, Karaj, Iran.
Firoozeh F; Department of Microbiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
Sameni F; Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran.
Yaslianifard S; Department of Microbiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
Goudarzi M; Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Dadashi M; Department of Microbiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran. m_.; Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran. m_.
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Źródło:
BMC gastroenterology [BMC Gastroenterol] 2024 Feb 23; Vol. 24 (1), pp. 82. Date of Electronic Publication: 2024 Feb 23.
Typ publikacji:
Journal Article
MeSH Terms:
Colorectal Neoplasms*/pathology
Colorectal Neoplasms, Hereditary Nonpolyposis*/diagnosis
Colorectal Neoplasms, Hereditary Nonpolyposis*/genetics
Colorectal Neoplasms, Hereditary Nonpolyposis*/pathology
Humans ; DNA Mismatch Repair/genetics ; Bacteroides fragilis/genetics ; Bacteroides fragilis/metabolism ; Iran ; MutS Homolog 2 Protein/genetics ; MutS Homolog 2 Protein/metabolism ; Microsatellite Instability ; DNA-Binding Proteins/genetics ; MutL Protein Homolog 1/genetics ; MutL Protein Homolog 1/metabolism ; Biopsy
Czasopismo naukowe
Tytuł:
Epigenetic MLH1 silencing concurs with mismatch repair deficiency in sporadic, naturally occurring colorectal cancer in rhesus macaques.
Autorzy:
Deycmar S; Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.; Roche Postdoctoral Fellowship (RPF) Program, Basel, Switzerland.
Johnson BJ; Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Ray K; Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, USA.
Schaaf GW; Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Ryan DP; School of Veterinary Medicine, University of California Davis, Davis, CA, USA.
Cullin C; Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, USA.
Dozier BL; Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, USA.
Ferguson B; Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, USA.
Bimber BN; Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, USA.
Olson JD; Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Caudell DL; Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Whitlow CT; Department of Radiology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Solingapuram Sai KK; Department of Radiology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Romero EC; New Iberia Research Center, University of Louisiana-Lafayette, New Iberia, LA, USA.
Villinger FJ; New Iberia Research Center, University of Louisiana-Lafayette, New Iberia, LA, USA.
Burgos AG; Caribbean Primate Research Center, University of Puerto Rico, Toa Baja, PR, USA.
Ainsworth HC; Department of Biostatistics and Data Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Miller LD; Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.; Center for Cancer Genomics and Precision Oncology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Hawkins GA; Center for Cancer Genomics and Precision Oncology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.; Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Chou JW; Center for Cancer Genomics and Precision Oncology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Gomes B; Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland.
Hettich M; Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland.
Ceppi M; Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland.; iTeos Therapeutics, Translational Medicine, Gosselies, Belgium.
Charo J; Roche Pharma Research and Early Development, Roche Innovation Center Zurich, Zurich, Switzerland.
Cline JM; Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC, USA. .
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Źródło:
Journal of translational medicine [J Transl Med] 2024 Mar 19; Vol. 22 (1), pp. 292. Date of Electronic Publication: 2024 Mar 19.
Typ publikacji:
Journal Article
MeSH Terms:
Microsatellite Instability*
Colorectal Neoplasms*/pathology
Brain Neoplasms*
Neoplastic Syndromes, Hereditary*
Humans ; Animals ; Macaca mulatta/genetics ; Macaca mulatta/metabolism ; MutL Protein Homolog 1/genetics ; Mismatch Repair Endonuclease PMS2/genetics ; Mismatch Repair Endonuclease PMS2/metabolism ; DNA Methylation/genetics ; Epigenesis, Genetic ; Transcription Factors/genetics ; Transcription Factors/metabolism ; DNA/metabolism ; DNA Mismatch Repair/genetics
SCR Disease Name:
Turcot syndrome
Czasopismo naukowe
Tytuł:
Germline variants screening of MLH1, MSH2, MSH6 and PMS2 genes in 64 Algerian Lynch syndrome families: The first nationwide study.
Autorzy:
Boumehdi AL; Molecular Genetics Team, LMCB, Faculty of Biological Sciences, University of Science and Technology Houari Boumediene, Algiers, Algeria.
Cherbal F; Molecular Genetics Team, LMCB, Faculty of Biological Sciences, University of Science and Technology Houari Boumediene, Algiers, Algeria.
Khider F; Molecular Genetics Team, LMCB, Faculty of Biological Sciences, University of Science and Technology Houari Boumediene, Algiers, Algeria.
Oukkal M; Clinic of Medical Oncology Amine Zirout, University Hospital of Beni-Messous, School of Medicine, University of Algiers-1, Algiers, Algeria.
Mahfouf H; Mohamed El Kolli Public Hospital, Academic Medical Oncology Services, School of Medicine, University of Algiers-1, Rouiba, Algeria.
Zebboudj F; Mohamed El Kolli Public Hospital, Academic General Surgery Services, School of Medicine, University of Algiers-1, Rouiba, Algeria.
Maaoui M; Bachir Mentouri Public Hospital, Academic General Surgery Services, School of Medicine, University of Algiers-1, Kouba, Algeria.
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Źródło:
Annals of human genetics [Ann Hum Genet] 2022 Nov; Vol. 86 (6), pp. 328-352. Date of Electronic Publication: 2022 Sep 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Colorectal Neoplasms, Hereditary Nonpolyposis*/genetics
Colorectal Neoplasms, Hereditary Nonpolyposis*/diagnosis
Colorectal Neoplasms, Hereditary Nonpolyposis*/pathology
Mismatch Repair Endonuclease PMS2*/genetics
MutL Protein Homolog 1*/genetics
MutS Homolog 2 Protein*/genetics
Female ; Humans ; Male ; Algeria ; Germ-Line Mutation
Czasopismo naukowe
Tytuł:
Rare germline mutation and MSH2-&MSH6 + expression in a double primary carcinoma of colorectal carcinoma and endometrial carcinoma: a case report.
Autorzy:
Zhang T; Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou Guangdong, 510623, China.
Huang X; Guangzhou KingMed Center for Clinical Laboratory Co. Ltd, Guangzhou, China. .
Liu W; Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou Guangdong, 510623, China.
Ling X; Meizhou Maternal and Child Health Care Hospital, Meizhou, 514000, Guangdong, China.
Su Z; Shenzhen KingMed Medical Laboratory, Shenzhen, China.
Huang M; Meizhou Maternal and Child Health Care Hospital, Meizhou, 514000, Guangdong, China.
Che S; Guangzhou KingMed Center for Clinical Laboratory Co. Ltd, Guangzhou, China. .
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Źródło:
Diagnostic pathology [Diagn Pathol] 2024 Jan 31; Vol. 19 (1), pp. 25. Date of Electronic Publication: 2024 Jan 31.
Typ publikacji:
Case Reports; Journal Article
MeSH Terms:
Brain Neoplasms*
Colorectal Neoplasms*/genetics
Colorectal Neoplasms, Hereditary Nonpolyposis*/diagnosis
Colorectal Neoplasms, Hereditary Nonpolyposis*/genetics
Endometrial Neoplasms*/genetics
Endometrial Neoplasms*/pathology
Neoplastic Syndromes, Hereditary*
Female ; Humans ; Middle Aged ; DNA Mismatch Repair ; Germ-Line Mutation ; Mismatch Repair Endonuclease PMS2/genetics ; MutL Protein Homolog 1/genetics ; MutS Homolog 2 Protein/genetics
SCR Disease Name:
Turcot syndrome
Czasopismo naukowe
Tytuł:
Association of a novel frameshift variant and a known deleterious variant in MMR genes with Lynch syndrome in Chinese families.
Autorzy:
Li J; Department of Pharmacy, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. .
Ni H; Department of Pathology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Wang X; Department of Pain, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Cheng W; Department of Endocrinology, Institute of Geriatric Medicine, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Li L; Department of Oncology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Cheng Y; Department of Gastrointestinal Surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Liu C; Hubei Key Laboratory of Diabetes and Angiopathy, Hubei University of Science and Technology, Xianning, Hubei, 437000, China.
Li Y; Department of Pharmacy, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. .
Deng A; Department of Pharmacy, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. .
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Źródło:
World journal of surgical oncology [World J Surg Oncol] 2024 Jan 27; Vol. 22 (1), pp. 36. Date of Electronic Publication: 2024 Jan 27.
Typ publikacji:
Journal Article
MeSH Terms:
Colorectal Neoplasms, Hereditary Nonpolyposis*/genetics
Colorectal Neoplasms, Hereditary Nonpolyposis*/pathology
Neoplastic Syndromes, Hereditary*
Humans ; DNA Mismatch Repair/genetics ; Germ-Line Mutation ; DNA-Binding Proteins/genetics ; China/epidemiology ; MutL Protein Homolog 1/genetics ; Mismatch Repair Endonuclease PMS2/genetics ; Mismatch Repair Endonuclease PMS2/metabolism
Czasopismo naukowe
Tytuł:
Comparison of immediate germline sequencing and multi-step screening for Lynch syndrome detection in high-risk endometrial and colorectal cancer patients.
Autorzy:
Chao AS; Department of Obstetrics and Gynecology, New Taipei Municipal Tu Cheng Hospital, New Taipei City, Taiwan.; Department of Obstetrics and Gynecology, Linkou Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Taoyuan, Taiwan.
Chao A; Department of Obstetrics and Gynecology, Linkou Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Taoyuan, Taiwan.; Gynecologic Cancer Research Center, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Lai CH; Department of Obstetrics and Gynecology, Linkou Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Taoyuan, Taiwan.; Gynecologic Cancer Research Center, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Lin CY; Department of Obstetrics and Gynecology, Linkou Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Taoyuan, Taiwan.; Gynecologic Cancer Research Center, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Yang LY; Biostatistics Unit, Clinical Trial Center, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Chang SC; Department of Laboratory Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Wu RC; Gynecologic Cancer Research Center, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.; Department of Pathology, Chang Gung Memorial Hospital Linkou Medical Center and Chang Gung University College of Medicine, Taoyuan, Taiwan. .
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Źródło:
Journal of gynecologic oncology [J Gynecol Oncol] 2024 Jan; Vol. 35 (1), pp. e5. Date of Electronic Publication: 2023 Sep 05.
Typ publikacji:
Journal Article
MeSH Terms:
Colorectal Neoplasms, Hereditary Nonpolyposis*/diagnosis
Colorectal Neoplasms, Hereditary Nonpolyposis*/genetics
Endometrial Neoplasms*/diagnosis
Endometrial Neoplasms*/genetics
Endometrial Neoplasms*/pathology
Humans ; Female ; Biomarkers, Tumor/analysis ; Early Detection of Cancer/methods ; Germ Cells/chemistry ; Germ Cells/metabolism ; Germ Cells/pathology ; DNA Mismatch Repair/genetics ; MutL Protein Homolog 1/genetics ; DNA Methylation
Czasopismo naukowe
Tytuł:
Prevalence and characteristics of patients with upper urinary tract urothelial carcinoma having potential Lynch syndrome identified by immunohistochemical universal screening and Amsterdam criteria II.
Autorzy:
Tanabe K; Department of Urology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa-Shi, Chiba, 277-8577, Japan.
Nakanishi Y; Department of Urology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa-Shi, Chiba, 277-8577, Japan. .
Okubo N; Department of Urology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa-Shi, Chiba, 277-8577, Japan.
Matsumoto S; Department of Urology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa-Shi, Chiba, 277-8577, Japan.
Umino Y; Department of Urology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa-Shi, Chiba, 277-8577, Japan.
Kataoka M; Department of Urology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa-Shi, Chiba, 277-8577, Japan.
Yajima S; Department of Urology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa-Shi, Chiba, 277-8577, Japan.
Yoshida T; Department of Genetic Medicine, National Cancer Center Hospital, Tokyo, Japan.
Miyazaki S; Department of Pathology and Clinical Laboratories, National Cancer Center Hospital East, Chiba, Japan.
Kuwata T; Department of Pathology and Clinical Laboratories, National Cancer Center Hospital East, Chiba, Japan.; Department of Genetic Medicine, National Cancer Center Hospital East, Chiba, Japan.
Ishii G; Department of Pathology and Clinical Laboratories, National Cancer Center Hospital East, Chiba, Japan.
Watanabe R; Department of Genetic Medicine, National Cancer Center Hospital, Tokyo, Japan.; Department of Pathology, St. Marianna University School of Medicine, Kanagawa, Japan.
Masuda H; Department of Urology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa-Shi, Chiba, 277-8577, Japan.
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Źródło:
BMC cancer [BMC Cancer] 2023 Oct 05; Vol. 23 (1), pp. 940. Date of Electronic Publication: 2023 Oct 05.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Transitional Cell*/diagnosis
Carcinoma, Transitional Cell*/epidemiology
Carcinoma, Transitional Cell*/genetics
Colorectal Neoplasms, Hereditary Nonpolyposis*/diagnosis
Colorectal Neoplasms, Hereditary Nonpolyposis*/epidemiology
Colorectal Neoplasms, Hereditary Nonpolyposis*/genetics
Urinary Bladder Neoplasms*
Kidney Neoplasms*
Ureteral Neoplasms*/diagnosis
Ureteral Neoplasms*/epidemiology
Urinary Tract*/metabolism
Urinary Tract*/pathology
Humans ; Female ; Male ; Mismatch Repair Endonuclease PMS2/genetics ; Mismatch Repair Endonuclease PMS2/metabolism ; Retrospective Studies ; Prevalence ; MutS Homolog 2 Protein/genetics ; MutS Homolog 2 Protein/metabolism ; MutL Protein Homolog 1/genetics ; MutL Protein Homolog 1/metabolism ; DNA Mismatch Repair
Czasopismo naukowe
Tytuł:
Key role of phosphorylation sites in ATPase domain and Linker region of MLH1 for DNA binding and functionality of MutLα.
Autorzy:
Firnau MB; Goethe University Frankfurt, University Hospital, Medical Clinic 1, Biomedical Research Laboratory, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.
Plotz G; Goethe University Frankfurt, University Hospital, Medical Clinic 1, Biomedical Research Laboratory, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.
Zeuzem S; Goethe University Frankfurt, University Hospital, Medical Clinic 1, Biomedical Research Laboratory, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.
Brieger A; Goethe University Frankfurt, University Hospital, Medical Clinic 1, Biomedical Research Laboratory, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany. .
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Źródło:
Scientific reports [Sci Rep] 2023 Aug 02; Vol. 13 (1), pp. 12503. Date of Electronic Publication: 2023 Aug 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA Mismatch Repair*
DNA*/metabolism
Humans ; Mismatch Repair Endonuclease PMS2/genetics ; Mismatch Repair Endonuclease PMS2/metabolism ; MutL Protein Homolog 1/genetics ; MutL Protein Homolog 1/metabolism ; Phosphorylation ; Protein Domains ; MutL Proteins/genetics ; MutL Proteins/metabolism
Czasopismo naukowe
Tytuł:
Double Duty: Complete Pathologic Response of Two Colonic Primaries with Mosaicism of a Novel MLH1 Mutation to Neoadjuvant Pembrolizumab.
Autorzy:
Preti B; Division of Medical Oncology, Department of Oncology, Western University, London, ON N6A 3K7, Canada.
Schenkel L; Division of Molecular Diagnostics, Western University, London, ON N6A 3K7, Canada.
Cecchini M; Department of Pathology and Laboratory Medicine, Western University, London, ON N6A 3K7, Canada.
Romagnoli T; Department of Pathology and Laboratory Medicine, Western University, London, ON N6A 3K7, Canada.; Schulich School of Medicine & Dentistry, Western University, London, ON N6A 3K7, Canada.
Sanatani MS; Division of Medical Oncology, Department of Oncology, Western University, London, ON N6A 3K7, Canada.
French K; Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A1, Canada.
Colquhoun P; Department of Surgery, Western University, London, ON N6A 3K7, Canada.
Vincent MD; Division of Medical Oncology, Department of Oncology, Western University, London, ON N6A 3K7, Canada.
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Źródło:
Current oncology (Toronto, Ont.) [Curr Oncol] 2023 Oct 06; Vol. 30 (10), pp. 9039-9048. Date of Electronic Publication: 2023 Oct 06.
Typ publikacji:
Case Reports
MeSH Terms:
Mosaicism*
Neoadjuvant Therapy*
Colonic Neoplasms*/drug therapy
Colonic Neoplasms*/genetics
Humans ; Male ; Middle Aged ; Microsatellite Instability ; Mutation ; MutL Protein Homolog 1/genetics
Raport

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