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Wyszukujesz frazę ""Mutagenesis"" wg kryterium: Temat


Starter badań:

Tytuł :
Creation of Golden Gate constructs for gene doctoring.
Autorzy :
Thomson NM; Quadram Institute Bioscience, Norwich Research Park, Norwich, Norfolk, NR4 7UQ, UK.
Zhang C; Quadram Institute Bioscience, Norwich Research Park, Norwich, Norfolk, NR4 7UQ, UK.; National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.; Guangdong Key Laboratory for Veterinary Drug Development and Safety evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.
Trampari E; Quadram Institute Bioscience, Norwich Research Park, Norwich, Norfolk, NR4 7UQ, UK.
Pallen MJ; Quadram Institute Bioscience, Norwich Research Park, Norwich, Norfolk, NR4 7UQ, UK. .; School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, Norfolk, NR4 7TU, UK. .; School of Veterinary Medicine, University of Surrey, Daphne Jackson Road, Guildford, Surrey, GU2 7AL, UK. .
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Źródło :
BMC biotechnology [BMC Biotechnol] 2020 Oct 07; Vol. 20 (1), pp. 54. Date of Electronic Publication: 2020 Oct 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Engineering*
Mutagenesis*
Bacteria ; Chromosomes ; DNA ; Enterobacteriaceae ; Escherichia coli/genetics ; Gene Deletion ; Gene Editing ; Genetic Vectors ; Mutagenesis, Insertional ; Plasmids ; Whole Genome Sequencing
Czasopismo naukowe
Tytuł :
Efficient collection of a large number of mutations by mutagenesis of DNA damage response defective animals.
Autorzy :
Suehiro Y; Department of Physiology, Tokyo Women's Medical University, Shinjuku, Tokyo, Japan.
Yoshina S; Department of Physiology, Tokyo Women's Medical University, Shinjuku, Tokyo, Japan.
Motohashi T; Department of Physiology, Tokyo Women's Medical University, Shinjuku, Tokyo, Japan.
Iwata S; Chubu University Center for Education in Laboratory Animal Research, Kasugai, Aichi, Japan.
Dejima K; Department of Physiology, Tokyo Women's Medical University, Shinjuku, Tokyo, Japan.
Mitani S; Department of Physiology, Tokyo Women's Medical University, Shinjuku, Tokyo, Japan. .; Tokyo Women's Medical University Institute for Integrated Medical Sciences, Shinjuku, Tokyo, Japan. .
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Źródło :
Scientific reports [Sci Rep] 2021 Apr 07; Vol. 11 (1), pp. 7630. Date of Electronic Publication: 2021 Apr 07.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Repair/*genetics
Mutagenesis, Site-Directed/*methods
Animals ; Ataxia Telangiectasia Mutated Proteins/genetics ; Base Sequence/genetics ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans Proteins/genetics ; DNA/genetics ; DNA Damage/genetics ; Gene Library ; Genetic Techniques ; High-Throughput Nucleotide Sequencing/methods ; Mutagenesis/genetics ; Mutagens ; Mutation/genetics ; Phenotype ; Sequence Analysis, DNA/methods
Czasopismo naukowe
Tytuł :
Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide.
Autorzy :
Jamsen JA; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA.
Sassa A; Laboratory of Chromatin Metabolism and Epigenetics, Graduate School of Science, Chiba University, Chiba, Japan.
Shock DD; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA.
Beard WA; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA.
Wilson SH; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Apr 06; Vol. 12 (1), pp. 2059. Date of Electronic Publication: 2021 Apr 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
DNA Breaks, Double-Stranded*
DNA Repair*
DNA-Directed DNA Polymerase/*metabolism
Mutagenesis/*genetics
Nucleotides/*metabolism
Adenine/metabolism ; Base Pairing ; Biocatalysis ; Catalytic Domain ; Cytosine/metabolism ; Deoxyguanine Nucleotides/metabolism ; Humans ; Models, Molecular ; Mutagenesis, Insertional/genetics ; Oxidation-Reduction
Czasopismo naukowe
Tytuł :
Mutagenesis for Improvement of Activity and Stability of Prolyl Aminopeptidase from Aspergillus oryzae.
Autorzy :
Liu D; The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, China.
Zhang D; The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, China.
Huang Q; The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, China.
Gu L; The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, China.
Zhou N; The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, China. .
Tian Y; The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, China. .
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Źródło :
Applied biochemistry and biotechnology [Appl Biochem Biotechnol] 2020 Aug; Vol. 191 (4), pp. 1483-1498. Date of Electronic Publication: 2020 Mar 03.
Typ publikacji :
Journal Article
MeSH Terms :
Mutagenesis*
Aminopeptidases/*metabolism
Aspergillus oryzae/*enzymology
Aminopeptidases/genetics ; Enzyme Stability ; Escherichia coli/metabolism ; Hydrogen-Ion Concentration ; Industrial Microbiology ; Kinetics ; Molecular Docking Simulation ; Mutagenesis, Site-Directed ; Mutation ; Temperature
Czasopismo naukowe
Tytuł :
Mutation Maker, An Open Source Oligo Design Platform for Protein Engineering.
Autorzy :
Hiraga K; Protein Engineering, MRL, Merck & Co. Inc., Rahway, New Jersey 07065, United States.
Mejzlik P; AI & Big Data Analytics, MSD Czech Republic s.r.o., 150 00 Prague, Czech Republic.
Marcisin M; R&D Informatics Solutions, MSD Czech Republic s.r.o., 150 00 Prague, Czech Republic.
Vostrosablin N; AI & Big Data Analytics, MSD Czech Republic s.r.o., 150 00 Prague, Czech Republic.
Gromek A; R&D Informatics Solutions, MSD Czech Republic s.r.o., 150 00 Prague, Czech Republic.
Arnold J; AI & Big Data Analytics, MSD Czech Republic s.r.o., 150 00 Prague, Czech Republic.
Wiewiora S; AI & Big Data Analytics, MSD Czech Republic s.r.o., 150 00 Prague, Czech Republic.
Svarba R; R&D Informatics Solutions, MSD Czech Republic s.r.o., 150 00 Prague, Czech Republic.
Prihoda D; R&D Informatics Solutions, MSD Czech Republic s.r.o., 150 00 Prague, Czech Republic.; Department of Informatics and Chemistry, Faculty of Chemical Technology, University of Chemistry and Technology, 166 28 Prague, Czech Republic.
Clarova K; R&D Informatics Solutions, MSD Czech Republic s.r.o., 150 00 Prague, Czech Republic.; Department of Informatics and Chemistry, Faculty of Chemical Technology, University of Chemistry and Technology, 166 28 Prague, Czech Republic.
Klempir O; R&D Informatics Solutions, MSD Czech Republic s.r.o., 150 00 Prague, Czech Republic.
Navratil J; R&D Informatics Solutions, MSD Czech Republic s.r.o., 150 00 Prague, Czech Republic.
Tupa O; R&D Informatics Solutions, MSD Czech Republic s.r.o., 150 00 Prague, Czech Republic.
Vazquez-Otero A; R&D Informatics Solutions, MSD Czech Republic s.r.o., 150 00 Prague, Czech Republic.
Walas MW; R&D Informatics Solutions, MSD Czech Republic s.r.o., 150 00 Prague, Czech Republic.
Holy L; R&D Informatics Solutions, MSD Czech Republic s.r.o., 150 00 Prague, Czech Republic.
Spale M; R&D Informatics Solutions, MSD Czech Republic s.r.o., 150 00 Prague, Czech Republic.
Kotowski J; AI & Big Data Analytics, MSD Czech Republic s.r.o., 150 00 Prague, Czech Republic.
Dzamba D; R&D Informatics Solutions, MSD Czech Republic s.r.o., 150 00 Prague, Czech Republic.
Temesi G; R&D Informatics Solutions, MSD Czech Republic s.r.o., 150 00 Prague, Czech Republic.
Russell JH; Protein Engineering, MRL, Merck & Co. Inc., Rahway, New Jersey 07065, United States.
Marshall NM; Protein Engineering, MRL, Merck & Co. Inc., Rahway, New Jersey 07065, United States.
Murphy GS; Protein Engineering, MRL, Merck & Co. Inc., Rahway, New Jersey 07065, United States.
Bitton DA; R&D Informatics Solutions, MSD Czech Republic s.r.o., 150 00 Prague, Czech Republic.
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Źródło :
ACS synthetic biology [ACS Synth Biol] 2021 Feb 19; Vol. 10 (2), pp. 357-370. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutagenesis*
Mutation*
Software*
Mutagenesis, Site-Directed/*methods
Oligonucleotides/*genetics
Proteins/*genetics
Algorithms ; Codon/genetics ; Computer Simulation ; Directed Molecular Evolution/methods ; Escherichia coli/genetics ; Gene Library ; Mutant Proteins
Czasopismo naukowe
Tytuł :
Mutagenicity of a novel 2-phenylbenzotriazole (non-chlorinated 2-phenylbenzotriazole-9) in mice.
Autorzy :
Rodrigues Tanamachi A; Department of Pathology, Medical School, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.; National Institute for Alternative Technologies of Detection, Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM), Institute of Chemistry, Araraquara, São Paulo, Brazil.
Fernandes FH; Department of Pathology, Medical School, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.; National Institute for Alternative Technologies of Detection, Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM), Institute of Chemistry, Araraquara, São Paulo, Brazil.
de Souza Vendemiatti JA; School of Technology, State University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.
Prediger P; School of Technology, State University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.
Camparotto NG; School of Technology, State University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.
Sousa Rocha N; School of Veterinary and Zootechnics, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.
Aragão Umbuzeiro G; School of Technology, State University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.
Fávero Salvadori DM; Department of Pathology, Medical School, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.; National Institute for Alternative Technologies of Detection, Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM), Institute of Chemistry, Araraquara, São Paulo, Brazil.
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Źródło :
Environmental and molecular mutagenesis [Environ Mol Mutagen] 2021 Oct; Vol. 62 (8), pp. 471-477. Date of Electronic Publication: 2021 Sep 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Damage*
Mutagenesis*
Mutagens/*toxicity
Triazoles/*toxicity
Water Pollutants, Chemical/*toxicity
Animals ; Male ; Mice ; Mutagenicity Tests
Czasopismo naukowe
Tytuł :
Genome-wide identification of probiotic Escherichia coli Nissle 1917 (EcN) fitness genes during adhesion to the intestinal epithelial cells Caco-2.
Autorzy :
Jayashree S; Department of Genetics, School of Biological Sciences, Madurai Kamaraj University, Madurai, India.
Sivakumar R; Department of Genetics, School of Biological Sciences, Madurai Kamaraj University, Madurai, India.
Karthikeyan R; Department of Genetics, School of Biological Sciences, Madurai Kamaraj University, Madurai, India.
Gunasekaran P; VIT Bhopal University, Sahore, India.
Rajendhran J; Department of Genetics, School of Biological Sciences, Madurai Kamaraj University, Madurai, India. Electronic address: .
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Źródło :
Gene [Gene] 2021 Nov 30; Vol. 803, pp. 145890. Date of Electronic Publication: 2021 Aug 08.
Typ publikacji :
Journal Article
MeSH Terms :
Mutagenesis, Insertional*
Escherichia coli/*physiology
Escherichia coli Proteins/*genetics
Sequence Analysis, DNA/*methods
Bacterial Adhesion ; Caco-2 Cells ; DNA Transposable Elements ; Escherichia coli/genetics ; Genetic Fitness ; High-Throughput Nucleotide Sequencing ; Humans ; Probiotics
Czasopismo naukowe
Tytuł :
Prognostic Value of EGFR Exon-20 Insertions in Czech Patients With Advanced Non-small Cell Lung Cancer.
Autorzy :
Skrickova J; Department of Pulmonary Diseases and Tuberculosis, University Hospital Brno, Brno, Czech Republic.
Pesek M; Department of Pneumology, University Hospital Pilsen, Pilsen, Czech Republic.
Opalka P; Clinic of Pneumology, Bulovka Hospital, Prague, Czech Republic.
Koubkova L; Department of Pneumology, Motol University Hospital, Prague, Czech Republic.
Zemanova M; Department of Oncology, General University Hospital in Prague, Prague, Czech Republic.; First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
Hrnciarik M; Department of Pneumology, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.; Faculty of Medicine, Charles University in Hradec Kralove, Hradec Kralove, Czech Republic.
Blazek J; Department of Pneumology, University Hospital Pilsen, Pilsen, Czech Republic.
Svaton M; Department of Pneumology, University Hospital Pilsen, Pilsen, Czech Republic.
Krejci J; Clinic of Pneumology, Bulovka Hospital, Prague, Czech Republic.
Coupkova H; Clinic of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
Dolezal D; Department of Pneumology, Masaryk Hospital Usti nad Labem, Usti nad Labem, Czech Republic.
Tuzova T; Department of Oncology, Hospital Jihlava, Jihlava, Czech Republic.
Holubec L; Department of Clinical Oncology, Na Homolce Hospital, Prague, Czech Republic.
Mahadevia P; Janssen Global Medical Affairs, Raritan, NJ, U.S.A.
Sandstrom K; Janssen Global Services, Stockholm, Sweden.
Kunovszki P; Janssen Global Services, Budapest, Hungary; .
Barinova M; Institute of Biostatistics and Analyses Ltd., Brno, Czech Republic.
Hurdalkova K; Institute of Biostatistics and Analyses Ltd., Brno, Czech Republic.
Fischer O; Department of Pulmonary Diseases and Tuberculosis, University Hospital Olomouc, Olomouc, Czech Republic.
Cernovska M; Department of Pneumology, University Hospital Pilsen, Pilsen, Czech Republic.
Bratova M; Department of Pulmonary Diseases and Tuberculosis, University Hospital Brno, Brno, Czech Republic.
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Źródło :
Anticancer research [Anticancer Res] 2021 Nov; Vol. 41 (11), pp. 5625-5634.
Typ publikacji :
Journal Article
MeSH Terms :
Mutagenesis, Insertional*
Carcinoma, Non-Small-Cell Lung/*genetics
Lung Neoplasms/*genetics
Adult ; Aged ; Aged, 80 and over ; Antineoplastic Agents/therapeutic use ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/mortality ; Carcinoma, Non-Small-Cell Lung/pathology ; Czech Republic ; Disease Progression ; Drug Resistance, Neoplasm ; ErbB Receptors/genetics ; Exons ; Female ; Genetic Predisposition to Disease ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/mortality ; Lung Neoplasms/pathology ; Male ; Middle Aged ; Phenotype ; Protein Kinase Inhibitors/therapeutic use ; Registries ; Retrospective Studies ; Time Factors ; Treatment Outcome ; Young Adult
Czasopismo naukowe
Tytuł :
Complex Transposon Insertion as a Novel Cause of Pompe Disease.
Autorzy :
Bychkov I; Research Centre for Medical Genetics, 115478 Moscow, Russia.
Baydakova G; Research Centre for Medical Genetics, 115478 Moscow, Russia.
Filatova A; Research Centre for Medical Genetics, 115478 Moscow, Russia.
Migiaev O; Research Centre for Medical Genetics, 115478 Moscow, Russia.
Marakhonov A; Research Centre for Medical Genetics, 115478 Moscow, Russia.
Pechatnikova N; Morozov Children's City Clinical Hospital, 119049 Moscow, Russia.
Pomerantseva E; Center of Genetics and Reproductive Medicine GENETICO, JSC, 119333 Moscow, Russia.
Konovalov F; Independent Clinical Bioinformatics Laboratory, 123181 Moscow, Russia.
Ampleeva M; Independent Clinical Bioinformatics Laboratory, 123181 Moscow, Russia.
Kaimonov V; Center of Genetics and Reproductive Medicine GENETICO, JSC, 119333 Moscow, Russia.
Skoblov M; Research Centre for Medical Genetics, 115478 Moscow, Russia.
Zakharova E; Research Centre for Medical Genetics, 115478 Moscow, Russia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 08; Vol. 22 (19). Date of Electronic Publication: 2021 Oct 08.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Mutagenesis, Insertional*
DNA Transposable Elements/*genetics
Glycogen Storage Disease Type II/*pathology
alpha-Glucosidases/*genetics
Child ; Female ; Glycogen Storage Disease Type II/etiology ; Glycogen Storage Disease Type II/metabolism ; Humans ; Infant ; Male ; Pedigree ; Prognosis
Czasopismo naukowe
Tytuł :
Epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus.
Autorzy :
Habig M; Environmental Genomics, Christian-Albrechts University of Kiel, Kiel, Germany. .; Max Planck Institute for Evolutionary Biology, Plön, Germany. .
Lorrain C; Environmental Genomics, Christian-Albrechts University of Kiel, Kiel, Germany.; Max Planck Institute for Evolutionary Biology, Plön, Germany.
Feurtey A; Environmental Genomics, Christian-Albrechts University of Kiel, Kiel, Germany.; Max Planck Institute for Evolutionary Biology, Plön, Germany.
Komluski J; Environmental Genomics, Christian-Albrechts University of Kiel, Kiel, Germany.; Max Planck Institute for Evolutionary Biology, Plön, Germany.
Stukenbrock EH; Environmental Genomics, Christian-Albrechts University of Kiel, Kiel, Germany. .; Max Planck Institute for Evolutionary Biology, Plön, Germany. .
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Źródło :
Nature communications [Nat Commun] 2021 Oct 07; Vol. 12 (1), pp. 5869. Date of Electronic Publication: 2021 Oct 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epigenesis, Genetic*
Mutagenesis*
Mutation Rate*
Fungi/*genetics
Ascomycota/genetics ; DNA Methylation ; DNA Transposable Elements ; Evolution, Molecular ; Genomic Instability ; Histone Code ; Histones ; Mutation ; Mutation Accumulation ; Temperature
Czasopismo naukowe
Tytuł :
The origin of human mutation in light of genomic data.
Autorzy :
Seplyarskiy VB; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Sunyaev S; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. .; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. .
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Źródło :
Nature reviews. Genetics [Nat Rev Genet] 2021 Oct; Vol. 22 (10), pp. 672-686. Date of Electronic Publication: 2021 Jun 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Genome, Human*
Mutagenesis*
Mutation*
Mutation Rate*
Genomics/*methods
Germ Cells/*metabolism
Humans
Czasopismo naukowe
Tytuł :
In Silico Mutagenesis-Based Remodelling of SARS-CoV-1 Peptide (ATLQAIAS) to Inhibit SARS-CoV-2: Structural-Dynamics and Free Energy Calculations.
Autorzy :
Khan A; Department of Bioinformatics and Biological Statistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China.
Umbreen S; Department of Botany, University of Okara, Okara, Punjab, Pakistan.
Hameed A; Department of Botany, University of Azad Jammu & Kashmir, Muzaffarabad, Azad Jammu & Kashmir, Pakistan.
Fatima R; Department of Chemistry, Bahauddin Zakariya University, Multan, Pakistan.
Zahoor U; Department of Botany, Women University, Bagh, Azad Jammu & Kashmir, Pakistan.
Babar Z; Center for Viticulture and Enology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China.
Waseem M; Faculty of Rehabilitation and Allied Health Science, Riphah International University, Islamabad, Pakistan.
Hussain Z; Center for Biotechnology and Microbiology, University of Swat, Swat, Khyber Pakhtunkhwa, Pakistan.
Rizwan M; Center for Biotechnology and Microbiology, University of Swat, Swat, Khyber Pakhtunkhwa, Pakistan.
Zaman N; Center for Biotechnology and Microbiology, University of Swat, Swat, Khyber Pakhtunkhwa, Pakistan.
Ali S; Center for Biotechnology and Microbiology, University of Swat, Swat, Khyber Pakhtunkhwa, Pakistan.
Suleman M; Center for Biotechnology and Microbiology, University of Swat, Swat, Khyber Pakhtunkhwa, Pakistan.
Shah A; Department of Biotechnology, Shaheed Benazir Bhutto University, Sheringal, Dir, Khyber Pakhtunkhwa, Pakistan.
Ali L; Department of Biological Sciences, National University of Medical Sciences (NUMS), Rawalpindi, Pakistan.
Ali SS; Center for Biotechnology and Microbiology, University of Swat, Swat, Khyber Pakhtunkhwa, Pakistan.
Wei DQ; Department of Bioinformatics and Biological Statistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China. .; State Key Laboratory of Microbial Metabolism, Shanghai-Islamabad-Belgrade Joint Innovation Center On Antibacterial Resistances, Joint Laboratory of International Cooperation in Metabolic and Developmental Sciences, Ministry of Education and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200030, People's Republic of China. .; Peng Cheng Laboratory, Vanke Cloud City Phase I Building 8, Xili Street, Nashan District, Shenzhen, Guangdong, 518055, People's Republic of China. .
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Źródło :
Interdisciplinary sciences, computational life sciences [Interdiscip Sci] 2021 Sep; Vol. 13 (3), pp. 521-534. Date of Electronic Publication: 2021 Jul 29.
Typ publikacji :
Journal Article
MeSH Terms :
Computer Simulation*
Molecular Dynamics Simulation*
Mutagenesis*
SARS Virus*/chemistry
SARS Virus*/genetics
Coronavirus 3C Proteases/*antagonists & inhibitors
Peptides/*chemistry
Peptides/*pharmacology
SARS-CoV-2/*drug effects
Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; COVID-19/virology ; Humans ; Molecular Docking Simulation ; Peptides/genetics ; Protease Inhibitors/chemistry ; Protease Inhibitors/pharmacology ; Protease Inhibitors/therapeutic use ; SARS-CoV-2/enzymology ; Thermodynamics
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Genes associated with amyloid-beta-induced inflammasome-mediated neuronal death identified using functional gene trap mutagenesis approach.
Autorzy :
Yap JKY; School of Postgraduate Studies, International Medical University, Kuala Lumpur, Malaysia.
Pickard BS; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, G4 0RE, United Kingdom.
Gan SY; Department of Life Sciences, School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia.
Chan EWL; Institute for Research, Development and Innovation, International Medical University, Kuala Lumpur, Malaysia. Electronic address: .
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Źródło :
The international journal of biochemistry & cell biology [Int J Biochem Cell Biol] 2021 Jul; Vol. 136, pp. 106014. Date of Electronic Publication: 2021 May 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Markers*
Mutagenesis*
Alzheimer Disease/*pathology
Amyloid beta-Peptides/*pharmacology
Inflammasomes/*genetics
Neuroblastoma/*pathology
Alzheimer Disease/etiology ; Alzheimer Disease/metabolism ; Humans ; Inflammasomes/metabolism ; NLR Proteins/genetics ; NLR Proteins/metabolism ; Neuroblastoma/etiology ; Neuroblastoma/metabolism ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Molnupiravir: coding for catastrophe.
Autorzy :
Malone B; Laboratory of Molecular Biophysics, The Rockefeller University, New York, NY, USA.
Campbell EA; Laboratory of Molecular Biophysics, The Rockefeller University, New York, NY, USA. .
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Źródło :
Nature structural & molecular biology [Nat Struct Mol Biol] 2021 Sep; Vol. 28 (9), pp. 706-708.
Typ publikacji :
Journal Article
MeSH Terms :
Mutagenesis*
Antiviral Agents/*pharmacology
COVID-19/*drug therapy
Cytidine/*analogs & derivatives
Genome, Viral/*drug effects
Hydroxylamines/*pharmacology
SARS-CoV-2/*drug effects
Antiviral Agents/chemistry ; Antiviral Agents/therapeutic use ; Base Pairing ; Cytidine/chemistry ; Cytidine/pharmacology ; Cytidine/therapeutic use ; DNA-Directed RNA Polymerases/metabolism ; Genes, Lethal ; Humans ; Hydroxylamines/chemistry ; Hydroxylamines/therapeutic use ; Molecular Structure ; Nucleic Acid Conformation ; RNA, Viral/biosynthesis ; RNA, Viral/chemistry ; RNA, Viral/drug effects ; RNA, Viral/genetics ; SARS-CoV-2/genetics ; Substrate Specificity ; Templates, Genetic ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
Plastomes from tribe Plantagineae (Plantaginaceae) reveal infrageneric structural synapormorphies and localized hypermutation for Plantago and functional loss of ndh genes from Littorella.
Autorzy :
Mower JP; Center for Plant Science Innovation, University of Nebraska, Lincoln, NE 68588, USA; Department of Agronomy and Horticulture, University of Nebraska, Lincoln, NE 68583, USA. Electronic address: .
Guo W; Center for Plant Science Innovation, University of Nebraska, Lincoln, NE 68588, USA; School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA.
Partha R; Center for Plant Science Innovation, University of Nebraska, Lincoln, NE 68588, USA.
Fan W; Center for Plant Science Innovation, University of Nebraska, Lincoln, NE 68588, USA; Department of Agronomy and Horticulture, University of Nebraska, Lincoln, NE 68583, USA.
Levsen N; School of Natural and Environmental Sciences, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK.
Wolff K; School of Natural and Environmental Sciences, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK.
Nugent JM; Department of Biology, National University of Ireland Maynooth, Maynooth, Co. Kildare, Ireland.
Pabón-Mora N; Instituto de Biología, Universidad de Antioquia, Apartado 1226, Medellín, Colombia.
González F; Universidad Nacional de Colombia, Sede Bogotá, Facultad de Ciencias, Instituto de Ciencias Naturales, Apartado 7495, Colombia.
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Źródło :
Molecular phylogenetics and evolution [Mol Phylogenet Evol] 2021 Sep; Vol. 162, pp. 107217. Date of Electronic Publication: 2021 Jun 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Evolution, Molecular*
Genome, Plastid*
Mutagenesis*
Phylogeny*
Genes, Plant/*genetics
NADH Dehydrogenase/*genetics
Plantaginaceae/*genetics
Photosynthesis ; Plantago/genetics ; Plastids/genetics
Czasopismo naukowe
Tytuł :
A body map of somatic mutagenesis in morphologically normal human tissues.
Autorzy :
Li R; Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University (PKU), Beijing, China.; Beijing Advanced Innovation Center for Genomics (ICG), Peking University, Beijing, China.
Di L; Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University (PKU), Beijing, China.; Beijing Advanced Innovation Center for Genomics (ICG), Peking University, Beijing, China.
Li J; School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China.; Beijing Advanced Innovation Center for Structural Biology (ICSB), Tsinghua University, Beijing, China.
Fan W; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China.
Liu Y; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China.
Guo W; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China.
Liu W; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China.
Liu L; Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University (PKU), Beijing, China.; Beijing Advanced Innovation Center for Genomics (ICG), Peking University, Beijing, China.
Li Q; School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China.; Beijing Advanced Innovation Center for Structural Biology (ICSB), Tsinghua University, Beijing, China.
Chen L; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China.
Chen Y; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China.
Miao C; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China.
Liu H; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China.
Wang Y; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China.
Ma Y; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China.
Xu D; Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University (PKU), Beijing, China.; Beijing Advanced Innovation Center for Genomics (ICG), Peking University, Beijing, China.
Lin D; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China. .; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China. .; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangzhou, China. .; CAMS Key Laboratory of Cancer Genomic Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. .
Huang Y; Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University (PKU), Beijing, China. .; Beijing Advanced Innovation Center for Genomics (ICG), Peking University, Beijing, China. .; College of Chemistry and Molecular Engineering, Beijing National Laboratory for Molecular Sciences, Peking University, Beijing, China. .; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China. .; Institute for Cell Analysis, Shenzhen Bay Laboratory, Guangdong, China. .
Wang J; School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China. .; Beijing Advanced Innovation Center for Structural Biology (ICSB), Tsinghua University, Beijing, China. .
Bai F; Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University (PKU), Beijing, China. .; Beijing Advanced Innovation Center for Genomics (ICG), Peking University, Beijing, China. .; Center for Translational Cancer Research, Peking University First Hospital, Beijing, China. .
Wu C; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China. .; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China. .; CAMS Key Laboratory of Cancer Genomic Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. .; CAMS Oxford Institute (COI), CAMS, Beijing, China. .
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Źródło :
Nature [Nature] 2021 Sep; Vol. 597 (7876), pp. 398-403. Date of Electronic Publication: 2021 Aug 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Health*
Mutagenesis*
Mutation*
Organ Specificity*
Clone Cells/*metabolism
Aged, 80 and over ; Biopsy ; Cadaver ; Cardia/metabolism ; Cell Proliferation ; Clone Cells/cytology ; Esophagus/metabolism ; Female ; Genomics ; Humans ; Male
Czasopismo naukowe
Tytuł :
CRISPR/Cas9-mediated targeted mutagenesis in Japanese cedar (Cryptomeria japonica D. Don).
Autorzy :
Nanasato Y; Forest Bio-Research Center, Forestry and Forest Products Research Institute, 3809-1 Ishi, Juo, Hitachi, Ibaraki, 319-1301, Japan. .
Mikami M; Graduate School of Nanobioscience, Yokohama City University, 22-2 Seto, Yokohama, Kanagawa, 236-0027, Japan.; Plant Genome Engineering Research Unit, Institute of Agrobiological Sciences, National Agriculture and Food Research Organization, 1-2 Owashi, Tsukuba, Ibaraki, 305-8634, Japan.
Futamura N; Department of Forest Molecular Genetics and Biotechnology, Forestry and Forest Products Research Institute, 1 Matsunosato, Tsukuba, Ibaraki, 305-8687, Japan.
Endo M; Graduate School of Nanobioscience, Yokohama City University, 22-2 Seto, Yokohama, Kanagawa, 236-0027, Japan.; Plant Genome Engineering Research Unit, Institute of Agrobiological Sciences, National Agriculture and Food Research Organization, 1-2 Owashi, Tsukuba, Ibaraki, 305-8634, Japan.; Kihara Institute for Biological Research, Yokohama City University, 641-12 Maioka-cho, Yokohama, Kanagawa, 244-0813, Japan.
Nishiguchi M; Department of Forest Molecular Genetics and Biotechnology, Forestry and Forest Products Research Institute, 1 Matsunosato, Tsukuba, Ibaraki, 305-8687, Japan.
Ohmiya Y; Department of Forest Molecular Genetics and Biotechnology, Forestry and Forest Products Research Institute, 1 Matsunosato, Tsukuba, Ibaraki, 305-8687, Japan.
Konagaya KI; Forest Bio-Research Center, Forestry and Forest Products Research Institute, 3809-1 Ishi, Juo, Hitachi, Ibaraki, 319-1301, Japan.
Taniguchi T; Forest Bio-Research Center, Forestry and Forest Products Research Institute, 3809-1 Ishi, Juo, Hitachi, Ibaraki, 319-1301, Japan.; Tohoku Regional Office, Forest Tree Breeding Center, Forestry and Forest Products Research Institute, 95 Osaki, Takizawa, Iwate, 020-0621, Japan.
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Źródło :
Scientific reports [Sci Rep] 2021 Aug 10; Vol. 11 (1), pp. 16186. Date of Electronic Publication: 2021 Aug 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CRISPR-Cas Systems*
Gene Editing*
Mutagenesis*
Mutation*
Cryptomeria/*genetics
Lyases/*antagonists & inhibitors
Plants, Genetically Modified/*genetics
Cryptomeria/growth & development ; Genetic Vectors ; Genome, Plant ; Japan ; Lyases/genetics ; Plants, Genetically Modified/growth & development
Czasopismo naukowe
Tytuł :
In silico saturation mutagenesis of cancer genes.
Autorzy :
Muiños F; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain. .
Martínez-Jiménez F; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Pich O; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Gonzalez-Perez A; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain. .; Research Program on Biomedical Informatics, Universitat Pompeu Fabra, Barcelona, Spain. .
Lopez-Bigas N; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain. .; Research Program on Biomedical Informatics, Universitat Pompeu Fabra, Barcelona, Spain. .; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain. .
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Źródło :
Nature [Nature] 2021 Aug; Vol. 596 (7872), pp. 428-432. Date of Electronic Publication: 2021 Jul 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Computer Simulation*
Machine Learning*
Mutagenesis*
Mutation*
Neoplasms/*genetics
Oncogenes/*genetics
Cell Transformation, Neoplastic/genetics ; Humans ; Models, Genetic ; Organ Specificity/genetics ; Precision Medicine ; Probability ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice.
Autorzy :
Rios JJ; Center for Pediatric Bone Biology and Translational Research, Scottish Rite for Children, Dallas, TX, USA.; Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX, USA.; McDermott Center for Human Growth and Development, UT Southwestern Medical Center, Dallas, TX, USA.; Department of Orthopaedic Surgery, UT Southwestern Medical Center, Dallas, TX, USA.; Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX, USA.
Denton K; Center for Pediatric Bone Biology and Translational Research, Scottish Rite for Children, Dallas, TX, USA.
Russell J; Center for Genetics of Host Defense, UT Southwestern Medical Center, Dallas, TX, USA.
Kozlitina J; McDermott Center for Human Growth and Development, UT Southwestern Medical Center, Dallas, TX, USA.
Ferreira CR; Skeletal Genomics Unit, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Lewanda AF; Rare Disease Institute, Children's National Hospital, Washington, DC, USA.
Mayfield JE; Department of Pharmacology, University of California, San Diego, CA, USA.
Moresco E; Center for Genetics of Host Defense, UT Southwestern Medical Center, Dallas, TX, USA.
Ludwig S; Center for Genetics of Host Defense, UT Southwestern Medical Center, Dallas, TX, USA.
Tang M; Center for Genetics of Host Defense, UT Southwestern Medical Center, Dallas, TX, USA.
Li X; Center for Genetics of Host Defense, UT Southwestern Medical Center, Dallas, TX, USA.
Lyon S; Center for Genetics of Host Defense, UT Southwestern Medical Center, Dallas, TX, USA.
Khanshour A; Center for Pediatric Bone Biology and Translational Research, Scottish Rite for Children, Dallas, TX, USA.
Paria N; Center for Pediatric Bone Biology and Translational Research, Scottish Rite for Children, Dallas, TX, USA.
Khalid A; Center for Pediatric Bone Biology and Translational Research, Scottish Rite for Children, Dallas, TX, USA.
Li Y; Center for Pediatric Bone Biology and Translational Research, Scottish Rite for Children, Dallas, TX, USA.
Xie X; Department of Restorative Sciences, School of Dentistry, Texas A&M University, Dallas, TX, USA.
Feng JQ; Department of Restorative Sciences, School of Dentistry, Texas A&M University, Dallas, TX, USA.
Xu Q; Department of Restorative Sciences, School of Dentistry, Texas A&M University, Dallas, TX, USA.
Lu Y; Department of Restorative Sciences, School of Dentistry, Texas A&M University, Dallas, TX, USA.
Hammer RE; Department of Biochemistry, UT Southwestern Medical Center, Dallas, TX, USA.
Wise CA; Center for Pediatric Bone Biology and Translational Research, Scottish Rite for Children, Dallas, TX, USA.; Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX, USA.; McDermott Center for Human Growth and Development, UT Southwestern Medical Center, Dallas, TX, USA.; Department of Orthopaedic Surgery, UT Southwestern Medical Center, Dallas, TX, USA.
Beutler B; Center for Genetics of Host Defense, UT Southwestern Medical Center, Dallas, TX, USA.
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Źródło :
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research [J Bone Miner Res] 2021 Aug; Vol. 36 (8), pp. 1548-1565. Date of Electronic Publication: 2021 May 10.
Typ publikacji :
Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Germ Cells*
Mutagenesis*
Bone Diseases/*genetics
Animals ; Ethylnitrosourea ; Humans ; Mice ; Mutation ; Phenotype ; Phosphotransferases (Alcohol Group Acceptor)/genetics
Czasopismo naukowe
Tytuł :
The mutagenic impact of melphalan in multiple myeloma.
Autorzy :
Maura F; Myeloma Program, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA. .
Weinhold N; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit (CCU) Molecular Hematology/Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Diamond B; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Kazandjian D; Myeloma Program, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.; Multiple Myeloma Program, Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Rasche L; Department of Internal Medicine II, Division of Oncology and Hematology, Würzburg University Hospital, Würzburg, Germany.
Morgan G; Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA.
Landgren O; Myeloma Program, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA. .
Pokaż więcej
Źródło :
Leukemia [Leukemia] 2021 Aug; Vol. 35 (8), pp. 2145-2150. Date of Electronic Publication: 2021 May 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Mutagenesis*
Mutation*
Melphalan/*adverse effects
Multiple Myeloma/*pathology
Mutagens/*adverse effects
Neoplasm Proteins/*genetics
Humans ; Multiple Myeloma/drug therapy ; Multiple Myeloma/genetics
Czasopismo naukowe

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