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Wyszukujesz frazę ""Mutagenesis"" wg kryterium: Temat


Tytuł:
Targeted mutagenesis in rabbit using an engineered BhCas12b variant.
Autorzy:
Jia Y; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science, Jilin University, Changchun 130062, China.
Wang T; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science, Jilin University, Changchun 130062, China.
Zhao D; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science, Jilin University, Changchun 130062, China.
Liu Z; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science, Jilin University, Changchun 130062, China.
Sui T; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science, Jilin University, Changchun 130062, China.
Chen S; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science, Jilin University, Changchun 130062, China.
Li J; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science, Jilin University, Changchun 130062, China.
Lai L; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science, Jilin University, Changchun 130062, China.; CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.; Guangzhou Regenerative Medicine and Health Guang Dong Laboratory (GRMH-GDL), Guangzhou 510005, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.
Li Z; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science, Jilin University, Changchun 130062, China.
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Źródło:
Journal of molecular cell biology [J Mol Cell Biol] 2023 Apr 20; Vol. 14 (12).
Typ publikacji:
Letter; Research Support, Non-U.S. Gov't
MeSH Terms:
Mutagenesis*/genetics
Animals ; Rabbits ; Mutagenesis, Site-Directed
Raport
Tytuł:
Base-editing mutagenesis maps alleles to tune human T cell functions.
Autorzy:
Schmidt R; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. .; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria. .
Ward CC; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. .
Dajani R; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
Armour-Garb Z; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
Ota M; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; Department of Genetics, Stanford University, Stanford, CA, USA.
Allain V; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Université Paris Cité, INSERM UMR976, Hôpital Saint-Louis, Paris, France.
Hernandez R; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Layeghi M; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
Xing G; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; Center for Computational Biology, University of California, Berkeley, Berkeley, CA, USA.
Goudy L; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
Dorovskyi D; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.
Wang C; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; Biomedical Sciences Graduate Program, University of California, San Francisco, CA, USA.
Chen YY; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
Ye CJ; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Institute for Human Genetics (IHG), University of California, San Francisco, San Francisco, CA, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA.; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA.; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, USA.
Shy BR; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.
Gilbert LA; UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.; Department of Urology, University of California, San Francisco, San Francisco, USA.; Arc Institute, Palo Alto, CA, USA.
Eyquem J; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.; Institute for Human Genetics (IHG), University of California, San Francisco, San Francisco, CA, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA.; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.
Pritchard JK; Department of Genetics, Stanford University, Stanford, CA, USA.; Department of Biology, Stanford University, Stanford, CA, USA.
Dodgson SE; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
Marson A; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. .; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA. .; UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA. .; Institute for Human Genetics (IHG), University of California, San Francisco, San Francisco, CA, USA. .; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA. .; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA. .; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA. .; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA. .
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Źródło:
Nature [Nature] 2024 Jan; Vol. 625 (7996), pp. 805-812. Date of Electronic Publication: 2023 Dec 13.
Typ publikacji:
Journal Article
MeSH Terms:
Alleles*
Gene Editing*
Mutagenesis*/genetics
T-Lymphocytes*/immunology
T-Lymphocytes*/metabolism
Humans ; Amino Acids/genetics ; CRISPR-Cas Systems/genetics ; RNA, Guide, CRISPR-Cas Systems/genetics ; Lymphocyte Activation ; Cytokines/biosynthesis ; Cytokines/metabolism ; Gain of Function Mutation ; Loss of Function Mutation
Czasopismo naukowe
Tytuł:
Meiotic DNA breaks drive multifaceted mutagenesis in the human germ line.
Autorzy:
Hinch R; Big Data Institute, University of Oxford, Oxford, UK.
Donnelly P; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Genomics plc, Oxford, UK.
Hinch AG; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Dec; Vol. 382 (6674), pp. eadh2531. Date of Electronic Publication: 2023 Dec 01.
Typ publikacji:
Journal Article
MeSH Terms:
DNA Breaks, Double-Stranded*
DNA Repair*
Genome, Human*
Meiosis*/genetics
Mutagenesis*
Recombination, Genetic*
Humans ; Male ; Mutation ; Ovum/metabolism ; Semen/metabolism ; Translesion DNA Synthesis ; Female
Czasopismo naukowe
Tytuł:
Single-cell CRISPR screens in vivo map T cell fate regulomes in cancer.
Autorzy:
Zhou P; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Shi H; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Huang H; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Sun X; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Yuan S; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Chapman NM; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Connelly JP; Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, TN, USA.
Lim SA; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Saravia J; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Kc A; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Pruett-Miller SM; Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, TN, USA.
Chi H; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA. .
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Źródło:
Nature [Nature] 2023 Dec; Vol. 624 (7990), pp. 154-163. Date of Electronic Publication: 2023 Nov 15.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Differentiation*/drug effects
Cell Differentiation*/genetics
Clustered Regularly Interspaced Short Palindromic Repeats*/genetics
Gene Editing*
Mutagenesis*
Neoplasms*/genetics
Neoplasms*/immunology
Single-Cell Analysis*/methods
T-Lymphocytes, Cytotoxic*/cytology
T-Lymphocytes, Cytotoxic*/drug effects
T-Lymphocytes, Cytotoxic*/immunology
T-Lymphocytes, Cytotoxic*/metabolism
Humans ; Immune Checkpoint Inhibitors/immunology ; Immune Checkpoint Inhibitors/pharmacology
Czasopismo naukowe
Tytuł:
DNA mismatch repair protects the genome from oxygen-induced replicative mutagenesis.
Autorzy:
Lózsa R; Institute of Enzymology, Research Centre for Natural Sciences, H-1117 Budapest, Hungary.
Németh E; Institute of Enzymology, Research Centre for Natural Sciences, H-1117 Budapest, Hungary.
Gervai JZ; Institute of Enzymology, Research Centre for Natural Sciences, H-1117 Budapest, Hungary.
Márkus BG; Stavropoulos Center for Complex Quantum Matter, Department of Physics and Astronomy, University of Notre Dame, Notre Dame, IN 46556, USA.; Institute for Solid State Physics and Optics, Wigner Research Centre for Physics, H-1525 Budapest, Hungary.; Department of Physics, Institute of Physics, Budapest University of Technology and Economics, H-1111 Budapest, Hungary.
Kollarics S; Institute for Solid State Physics and Optics, Wigner Research Centre for Physics, H-1525 Budapest, Hungary.; Department of Physics, Institute of Physics, Budapest University of Technology and Economics, H-1111 Budapest, Hungary.
Gyüre Z; Institute of Enzymology, Research Centre for Natural Sciences, H-1117 Budapest, Hungary.; Doctoral School of Molecular Medicine, Semmelweis University, H-1085 Budapest, Hungary.; Turbine Simulated Cell Technologies, H-1027 Budapest, Hungary.
Tóth J; Institute of Enzymology, Research Centre for Natural Sciences, H-1117 Budapest, Hungary.; Department of Applied Biotechnology and Food Science, Budapest University of Technology and Economics, H-1111 Budapest, Hungary.
Simon F; Institute for Solid State Physics and Optics, Wigner Research Centre for Physics, H-1525 Budapest, Hungary.; Department of Physics, Institute of Physics, Budapest University of Technology and Economics, H-1111 Budapest, Hungary.
Szüts D; Institute of Enzymology, Research Centre for Natural Sciences, H-1117 Budapest, Hungary.; National Laboratory for Drug Research and Development, H-1117 Budapest, Hungary.
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Źródło:
Nucleic acids research [Nucleic Acids Res] 2023 Nov 10; Vol. 51 (20), pp. 11040-11055.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA Mismatch Repair*
Mutagenesis*
Oxygen*
Humans ; Base Pair Mismatch ; DNA Repair ; DNA Replication ; Mutation ; Cell Line
Czasopismo naukowe
Tytuł:
A molnupiravir-associated mutational signature in global SARS-CoV-2 genomes.
Autorzy:
Sanderson T; Francis Crick Institute, London, UK. .
Hisner R; Department of Bioinformatics, University of Cape Town, Cape Town, South Africa.
Donovan-Banfield I; Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.; Health Protection Research Unit in Emerging and Zoonotic Infections, National Institute for Health and Care Research, Liverpool, UK.
Hartman H; UK Health Security Agency, London, UK.
Løchen A; UK Health Security Agency, London, UK.
Peacock TP; Department of Infectious Disease, Imperial College London, London, UK.; The Pirbright Institute, Pirbright, UK.
Ruis C; Molecular Immunity Unit, University of Cambridge Department of Medicine, Medical Research Council-Laboratory of Molecular Biology, Cambridge, UK. .; Department of Veterinary Medicine, University of Cambridge, Cambridge, UK. .; Cambridge Centre for AI in Medicine, University of Cambridge, Cambridge, UK. .; Victor Phillip Dahdaleh Heart & Lung Research Institute, University of Cambridge, Cambridge, UK. .
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Źródło:
Nature [Nature] 2023 Nov; Vol. 623 (7987), pp. 594-600. Date of Electronic Publication: 2023 Sep 25.
Typ publikacji:
Journal Article
MeSH Terms:
Antiviral Agents*/pharmacology
Antiviral Agents*/therapeutic use
COVID-19*/epidemiology
COVID-19*/transmission
COVID-19*/virology
Cytidine*/analogs & derivatives
Cytidine*/pharmacology
Cytidine*/therapeutic use
Hydroxylamines*/pharmacology
Hydroxylamines*/therapeutic use
Mutation*/drug effects
SARS-CoV-2*/drug effects
SARS-CoV-2*/genetics
Mutagenesis*/drug effects
Humans ; Genome, Viral/drug effects ; Genome, Viral/genetics ; Phylogeny ; Viral Load ; Virus Replication/drug effects ; Virus Replication/genetics ; Evolution, Molecular ; COVID-19 Drug Treatment
Czasopismo naukowe
Tytuł:
Genome editing with retroelements.
Autorzy:
Tang S; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Sternberg SH; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Oct 27; Vol. 382 (6669), pp. 370-371. Date of Electronic Publication: 2023 Oct 26.
Typ publikacji:
Journal Article
MeSH Terms:
Gene Editing*/methods
Retroelements*
RNA, Guide, CRISPR-Cas Systems*/chemistry
Mutagenesis, Insertional*/methods
CRISPR-Associated Protein 9*/chemistry
CRISPR-Cas Systems ; Genome, Human ; Humans
Czasopismo naukowe
Tytuł:
Rational and random mutagenesis of GDEst-95 carboxylesterase: New functionality insights.
Autorzy:
Malunavicius V; Institute of Biosciences, Life Sciences Center, Vilnius University, Sauletekis avenue 7, LT-10257 Vilnius, Lithuania.
Vaskevicius L; Institute of Biosciences, Life Sciences Center, Vilnius University, Sauletekis avenue 7, LT-10257 Vilnius, Lithuania.
Gusaite A; Institute of Biosciences, Life Sciences Center, Vilnius University, Sauletekis avenue 7, LT-10257 Vilnius, Lithuania.
Gudiukaite R; Institute of Biosciences, Life Sciences Center, Vilnius University, Sauletekis avenue 7, LT-10257 Vilnius, Lithuania. Electronic address: .
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Źródło:
International journal of biological macromolecules [Int J Biol Macromol] 2024 Jan; Vol. 256 (Pt 1), pp. 128331. Date of Electronic Publication: 2023 Nov 25.
Typ publikacji:
Journal Article
MeSH Terms:
Carboxylesterase*/chemistry
Geobacillus*
Mutagenesis ; Carboxylic Ester Hydrolases/chemistry ; Mutagenesis, Site-Directed
Czasopismo naukowe
Tytuł:
Evelyn M. Witkin (1921-2023).
Autorzy:
Sweasy JB; The University of Arizona Comprehensive Cancer Center, Tucson, AZ, USA.
Hanawalt PC; Department of Biology, Stanford University, Stanford, CA, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Sep 08; Vol. 381 (6662), pp. 1052. Date of Electronic Publication: 2023 Sep 07.
Typ publikacji:
Journal Article
MeSH Terms:
DNA Repair*
Genetics*/history
Mutagenesis*
United States
Czasopismo naukowe
Tytuł:
Evolutionary histories of breast cancer and related clones.
Autorzy:
Nishimura T; Department of Pathology and Tumour Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Department of Next-generation Clinical Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Department of Breast Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kakiuchi N; Department of Pathology and Tumour Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; The Hakubi Center for Advanced Research, Kyoto University, Kyoto, Japan.; Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Yoshida K; Department of Pathology and Tumour Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Division of Cancer Evolution, National Cancer Center Research Institute, Tokyo, Japan.
Sakurai T; Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan.; Department of Diagnostic Pathology, Osaka Red Cross Hospital, Osaka, Japan.
Kataoka TR; Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan.; Department of Pathology, Iwate Medical University, Iwate, Japan.
Kondoh E; Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Department of Obstetrics and Gynecology Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Chigusa Y; Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kawai M; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Sawada M; Adachi Hospital, Kyoto, Japan.
Inoue T; Adachi Hospital, Kyoto, Japan.
Takeuchi Y; Department of Pathology and Tumour Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan.
Maeda H; Department of Pathology and Tumour Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan.
Baba S; Pathology Project for Molecular Targets, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.; Division of Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.; Department of Pathology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
Shiozawa Y; Department of Pathology and Tumour Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Saiki R; Department of Pathology and Tumour Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Nakagawa MM; Department of Pathology and Tumour Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Department of Next-generation Clinical Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Nannya Y; Department of Pathology and Tumour Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Division of Hematopoietic Disease Control, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Ochi Y; Department of Pathology and Tumour Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Hirano T; Department of Pathology and Tumour Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan.
Nakagawa T; Department of Pathology and Tumour Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan.
Inagaki-Kawata Y; Department of Pathology and Tumour Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Department of Breast Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Aoki K; Department of Pathology and Tumour Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Hirata M; Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan.
Nanki K; Department of Organoid Medicine, Sakaguchi Laboratory, Keio University School of Medicine, Tokyo, Japan.
Matano M; Department of Organoid Medicine, Sakaguchi Laboratory, Keio University School of Medicine, Tokyo, Japan.
Saito M; Department of Organoid Medicine, Sakaguchi Laboratory, Keio University School of Medicine, Tokyo, Japan.; Osaka Research Center for Drug Discovery, Otsuka Pharmaceutical Company, Limited, Osaka, Japan.
Suzuki E; Department of Breast Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Breast Surgery Department, Kobe City Medical Center General Hospital, Hyogo, Japan.
Takada M; Department of Breast Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kawashima M; Department of Breast Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kawaguchi K; Department of Breast Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Chiba K; Division of Genome Analysis Platform Development, National Cancer Center Research Institute, Tokyo, Japan.
Shiraishi Y; Division of Genome Analysis Platform Development, National Cancer Center Research Institute, Tokyo, Japan.
Takita J; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Miyano S; Department of Integrated Analytics, M&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan.; Human Genome Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Mandai M; Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Sato T; Department of Organoid Medicine, Sakaguchi Laboratory, Keio University School of Medicine, Tokyo, Japan.
Takeuchi K; Pathology Project for Molecular Targets, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.; Division of Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.; Department of Pathology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
Haga H; Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan.
Toi M; Department of Breast Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Ogawa S; Department of Pathology and Tumour Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. .; Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan. .; Department of Medicine, Centre for Haematology and Regenerative Medicine, Karolinska Institute, Stockholm, Sweden. .
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Źródło:
Nature [Nature] 2023 Aug; Vol. 620 (7974), pp. 607-614. Date of Electronic Publication: 2023 Jul 26.
Typ publikacji:
Journal Article
MeSH Terms:
Breast Neoplasms*/diagnosis
Breast Neoplasms*/genetics
Breast Neoplasms*/pathology
Cell Lineage*/genetics
Clone Cells*/metabolism
Clone Cells*/pathology
Evolution, Molecular*
Mutagenesis*
Mutation*
Adolescent ; Adult ; Female ; Humans ; Young Adult ; Epigenesis, Genetic ; Epithelial Cells/cytology ; Epithelial Cells/metabolism ; Epithelium/pathology ; Microdissection ; Mutation Rate ; Premenopause ; Tumor Microenvironment
Czasopismo naukowe
Tytuł:
DNA polymerase ε leading strand signature mutations result from defects in its proofreading activity.
Autorzy:
Johnson RE; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Prakash L; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Prakash S; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2023 Jul; Vol. 299 (7), pp. 104913. Date of Electronic Publication: 2023 Jun 10.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
DNA Polymerase II*/metabolism
DNA Replication*/genetics
Mutation*
Saccharomyces cerevisiae*/enzymology
Saccharomyces cerevisiae*/genetics
Saccharomyces cerevisiae Proteins*/metabolism
Mutagenesis*
DNA Polymerase III/metabolism
Czasopismo naukowe
Tytuł:
Enhancement of protein thermostability by three consecutive mutations using loop-walking method and machine learning.
Autorzy:
Yoshida K; Innovation Center, Amano Enzyme Inc., Technoplaza, Kakamigahara, Gifu, 509-0109, Japan.; Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University, Tsushima, Okayama, 700-8530, Japan.
Kawai S; Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Nagoya, 464-8601, Japan.
Fujitani M; Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Nagoya, 464-8601, Japan.
Koikeda S; Innovation Center, Amano Enzyme Inc., Technoplaza, Kakamigahara, Gifu, 509-0109, Japan. satoshi_.
Kato R; Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Nagoya, 464-8601, Japan. .
Ema T; Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University, Tsushima, Okayama, 700-8530, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2021 Jun 04; Vol. 11 (1), pp. 11883. Date of Electronic Publication: 2021 Jun 04.
Typ publikacji:
Journal Article
MeSH Terms:
Enzyme Stability*
Machine Learning*
Mutagenesis*
Mutation*
Burkholderia cepacia/*genetics
Lipase/*chemistry
Protein Engineering/*methods
Proteins/*chemistry
Proteins/*genetics
Computational Biology ; Escherichia coli/metabolism ; Hot Temperature ; Hydrolases/chemistry ; Kinetics ; Molecular Conformation ; Molecular Dynamics Simulation ; Mutagenesis, Site-Directed ; Plasmids/metabolism ; Polymerase Chain Reaction
Czasopismo naukowe
Tytuł:
Experimental modification in thermal stability of oligomers by alanine substitution and site saturation mutagenesis of interfacial residues.
Autorzy:
Hoya M; Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan; Sagami Chemical Research Institute, 2743-1 Hayakawa, Ayase, Kanagawa, 252-1193, Japan.
Matsunaga R; Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan; Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.
Nagatoishi S; Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan; Project Division of Advanced Biopharmaceutical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan. Electronic address: .
Tsumoto K; Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan; Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan; Project Division of Advanced Biopharmaceutical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan. Electronic address: .
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Źródło:
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Jan 08; Vol. 691, pp. 149316. Date of Electronic Publication: 2023 Nov 25.
Typ publikacji:
Journal Article
MeSH Terms:
Alanine*/genetics
Mutagenesis ; Mutation ; Mutagenesis, Site-Directed ; Chloramphenicol O-Acetyltransferase ; Enzyme Stability
Czasopismo naukowe
Tytuł:
Creation of Golden Gate constructs for gene doctoring.
Autorzy:
Thomson NM; Quadram Institute Bioscience, Norwich Research Park, Norwich, Norfolk, NR4 7UQ, UK.
Zhang C; Quadram Institute Bioscience, Norwich Research Park, Norwich, Norfolk, NR4 7UQ, UK.; National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.; Guangdong Key Laboratory for Veterinary Drug Development and Safety evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.
Trampari E; Quadram Institute Bioscience, Norwich Research Park, Norwich, Norfolk, NR4 7UQ, UK.
Pallen MJ; Quadram Institute Bioscience, Norwich Research Park, Norwich, Norfolk, NR4 7UQ, UK. .; School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, Norfolk, NR4 7TU, UK. .; School of Veterinary Medicine, University of Surrey, Daphne Jackson Road, Guildford, Surrey, GU2 7AL, UK. .
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Źródło:
BMC biotechnology [BMC Biotechnol] 2020 Oct 07; Vol. 20 (1), pp. 54. Date of Electronic Publication: 2020 Oct 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genetic Engineering*
Mutagenesis*
Bacteria ; Chromosomes ; DNA ; Enterobacteriaceae ; Escherichia coli/genetics ; Gene Deletion ; Gene Editing ; Genetic Vectors ; Mutagenesis, Insertional ; Plasmids ; Whole Genome Sequencing
Czasopismo naukowe
Tytuł:
UV-ARTP compound mutagenesis breeding improves macrolactins production of Bacillus siamensis and reveals metabolism changes by proteomic.
Autorzy:
Yu L; Department of Food Science and Engineering, College of Light Industry and Food Engineering, Guangxi University, Nanning, Guangxi 530004, China.
Li F; Guangxi Key Laboratory of Marine Environmental Science, Beibu Gulf Marine Research Center, Guangxi Academy of Sciences, Nanning 530007, China. Electronic address: .
Ni J; Department of Chemistry and Chemical, Guilin Normal College, Guilin 541199, China. Electronic address: .
Qin X; Guangxi Key Laboratory of Marine Environmental Science, Beibu Gulf Marine Research Center, Guangxi Academy of Sciences, Nanning 530007, China.
Lai J; Guangxi Key Laboratory of Marine Environmental Science, Beibu Gulf Marine Research Center, Guangxi Academy of Sciences, Nanning 530007, China.
Su X; Guangxi Key Laboratory of Marine Environmental Science, Beibu Gulf Marine Research Center, Guangxi Academy of Sciences, Nanning 530007, China.
Li Z; Guangxi Key Laboratory of Marine Environmental Science, Beibu Gulf Marine Research Center, Guangxi Academy of Sciences, Nanning 530007, China.
Zhang M; Department of Food Science and Engineering, College of Light Industry and Food Engineering, Guangxi University, Nanning, Guangxi 530004, China.
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Źródło:
Journal of biotechnology [J Biotechnol] 2024 Feb 10; Vol. 381, pp. 36-48. Date of Electronic Publication: 2024 Jan 06.
Typ publikacji:
Journal Article
MeSH Terms:
Proteomics*
Bacillus*/genetics
Bacillus*/chemistry
Mutagenesis ; Macrolides
SCR Organism:
Bacillus siamensis
Czasopismo naukowe
Tytuł:
Expanded MutaT7 toolkit efficiently and simultaneously accesses all possible transition mutations in bacteria.
Autorzy:
Mengiste AA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Wilson RH; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Weissman RF; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Papa Iii LJ; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Hendel SJ; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Moore CL; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Butty VL; BioMicroCenter, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Shoulders MD; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
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Źródło:
Nucleic acids research [Nucleic Acids Res] 2023 Apr 11; Vol. 51 (6), pp. e31.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Mutagenesis*
Adenosine Deaminase/genetics ; Escherichia coli/genetics ; Escherichia coli Proteins/genetics ; Mutation ; Genetic Techniques
Czasopismo naukowe
Tytuł:
Large-scale mapping and mutagenesis of human transcriptional effector domains.
Autorzy:
DelRosso N; Biophysics Program, Stanford University, Stanford, CA, USA.
Tycko J; Department of Genetics, Stanford University, Stanford, CA, USA.
Suzuki P; Department of Bioengineering, Stanford University, Stanford, CA, USA.
Andrews C; Department of Developmental Biology, Stanford University, Stanford, CA, USA.
Aradhana; Department of Genetics, Stanford University, Stanford, CA, USA.
Mukund A; Biophysics Program, Stanford University, Stanford, CA, USA.
Liongson I; Department of Biology, Stanford University, Stanford, CA, USA.
Ludwig C; Department of Bioengineering, Stanford University, Stanford, CA, USA.
Spees K; Department of Genetics, Stanford University, Stanford, CA, USA.
Fordyce P; Department of Genetics, Stanford University, Stanford, CA, USA.; Department of Bioengineering, Stanford University, Stanford, CA, USA.; ChEM-H Institute, Stanford University, Stanford, CA, USA.; Chan Zuckerberg Biohub, San Francisco, CA, USA.
Bassik MC; Department of Genetics, Stanford University, Stanford, CA, USA.
Bintu L; Department of Bioengineering, Stanford University, Stanford, CA, USA. .
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Źródło:
Nature [Nature] 2023 Apr; Vol. 616 (7956), pp. 365-372. Date of Electronic Publication: 2023 Apr 05.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Mutagenesis*
Transcription Factors*/chemistry
Transcription Factors*/genetics
Transcription Factors*/metabolism
Transcription, Genetic*
Protein Domains*/genetics
Gene Expression Regulation*
Humans ; Chromatin/genetics ; Chromatin/metabolism ; Genes, Reporter/genetics ; Repressor Proteins/chemistry ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Sumoylation
Czasopismo naukowe
Tytuł:
Mutagenesis for Improvement of Activity and Stability of Prolyl Aminopeptidase from Aspergillus oryzae.
Autorzy:
Liu D; The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, China.
Zhang D; The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, China.
Huang Q; The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, China.
Gu L; The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, China.
Zhou N; The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, China. .
Tian Y; The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, China. .
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Źródło:
Applied biochemistry and biotechnology [Appl Biochem Biotechnol] 2020 Aug; Vol. 191 (4), pp. 1483-1498. Date of Electronic Publication: 2020 Mar 03.
Typ publikacji:
Journal Article
MeSH Terms:
Mutagenesis*
Aminopeptidases/*metabolism
Aspergillus oryzae/*enzymology
Aminopeptidases/genetics ; Enzyme Stability ; Escherichia coli/metabolism ; Hydrogen-Ion Concentration ; Industrial Microbiology ; Kinetics ; Molecular Docking Simulation ; Mutagenesis, Site-Directed ; Mutation ; Temperature
Czasopismo naukowe
Tytuł:
A guide to barley mutants.
Autorzy:
Hansson M; Department of Biology, Lund University, Sölvegatan 35, 22362, Lund, Sweden. .
Youssef HM; Faculty of Agriculture, Cairo University, Giza, 12613, Egypt.; Institute of Agricultural and Nutritional Sciences, Faculty of Natural Sciences III, Martin Luther University Halle-Wittenberg, Halle, 06120, Germany.
Zakhrabekova S; Department of Biology, Lund University, Sölvegatan 35, 22362, Lund, Sweden.
Stuart D; Department of Biology, Lund University, Sölvegatan 35, 22362, Lund, Sweden.
Svensson JT; Nordic Genetic Resource Center (NordGen), Växthusvägen 12, 23456, Alnarp, Sweden.
Dockter C; Carlsberg Research Laboratory, J. C. Jacobsens Gade 4, 1799, Copenhagen V, Denmark.
Stein N; Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), OT Gatersleben, Stadt Seeland, E06466, Germany.; Center for Integrated Breeding Research (CiBreed), Georg-August-University, Göttingen, Germany.
Waugh R; Cell and Molecular Sciences, The James Hutton Institute, Invergowrie, Dundee, DD2 5DA, UK.; Division of Plant Sciences, University of Dundee, The James Hutton Institute, Invergowrie, Dundee, DD2 5DA, UK.; School of Agriculture Food and Wine, Waite Campus, The University of Adelaide, Urrbrae, 5064, Australia.
Lundqvist U; Nordic Genetic Resource Center (NordGen), Växthusvägen 12, 23456, Alnarp, Sweden.
Franckowiak J; Department of Agronomy and Plant Genetics, University of Minnesota Twin Cities, 411 Borlaug Hall, 1991 Upper Buford Circle, St Paul, MN, 55108, USA.
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Źródło:
Hereditas [Hereditas] 2024 Mar 08; Vol. 161 (1), pp. 11. Date of Electronic Publication: 2024 Mar 08.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Hordeum*/genetics
Plant Breeding ; Mutagenesis ; Genomics
Czasopismo naukowe
Tytuł:
Genomics of predictive radiation mutagenesis in oilseed rape: modifying seed oil composition.
Autorzy:
Havlickova L; Department of Biology, University of York, York, UK.
He Z; Department of Biology, University of York, York, UK.
Berger M; Department of Biology, University of York, York, UK.
Wang L; Department of Biology, University of York, York, UK.
Sandmann G; Department of Biology, University of York, York, UK.
Chew YP; Department of Biology, University of York, York, UK.
Yoshikawa GV; Department of Biology, University of York, York, UK.
Lu G; Department of Rapeseed Genetics and Breeding, Oil Crops Research Institute, CAAS, Wuhan, China.; College of Biology and Food Engineering, Guangdong University of Petrochemical Technology, Maoming, China.
Hu Q; Department of Rapeseed Genetics and Breeding, Oil Crops Research Institute, CAAS, Wuhan, China.
Banga SS; Department of Plant Breeding and Genetics, Punjab Agricultural University, Ludhiana, India.
Beaudoin F; Plant Sciences for the Bioeconomy, Rothamsted Research, Harpenden, UK.
Bancroft I; Department of Biology, University of York, York, UK.
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Źródło:
Plant biotechnology journal [Plant Biotechnol J] 2024 Mar; Vol. 22 (3), pp. 738-750. Date of Electronic Publication: 2023 Nov 03.
Typ publikacji:
Journal Article
MeSH Terms:
Brassica napus*/genetics
Brassica rapa*/genetics
Plant Breeding ; Genomics ; Mutagenesis/genetics ; Seeds/genetics ; Plant Oils
Czasopismo naukowe

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