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Wyświetlanie 61-80 z 93530
Tytuł:
Amivantamab compared with real-world therapies in patients with advanced non-small cell lung cancer EGFR Exon 20 insertion mutations after platinum-based chemotherapy.
Autorzy:
Kim TM; Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Girard N; Institut Curie, Institute du Thorax Curie-Montsouris, Paris, France.
Low GKM; Medical Affairs, Janssen Asia Pacific Medical Affairs, a division of Johnson & Johnson International (Singapore) Pte. Ltd.
Zhuo J; Statistics and Decision Science, Janssen China Research & Development, China.
Yu DY; Real World Evidence, Janssen Asia Pacific, Republic of Korea.
Yang Y; Statistics and Decision Science, Janssen China Research & Development, China.
Murota M; Global Development, Medical Affair Operations, Janssen Research & Development, Tokyo, Japan.
Lim CTK; Real World Solutions, IQVIA Solutions Asia Pte Ltd, Singapore.
Kleinman NJ; Real World Solutions, IQVIA Hong Kong, Kwai Fong, Hong Kong, P.R. China.
Cho BC; Department of Medical Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea.
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Źródło:
Acta oncologica (Stockholm, Sweden) [Acta Oncol] 2023 Dec; Vol. 62 (12), pp. 1689-1697. Date of Electronic Publication: 2023 Nov 25.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*/drug therapy
Carcinoma, Non-Small-Cell Lung*/genetics
Carcinoma, Non-Small-Cell Lung*/pathology
Lung Neoplasms*/drug therapy
Lung Neoplasms*/genetics
Lung Neoplasms*/pathology
Humans ; Platinum/therapeutic use ; Mutagenesis, Insertional ; Protein Kinase Inhibitors/therapeutic use ; ErbB Receptors/genetics ; Exons/genetics ; Mutation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Neuronal Scaffold Protein ARMS Interacts with Synaptotagmin-4 C2AB through the Ankyrin Repeat Domain with an Unexpected Mode.
Autorzy:
Zhang F; Hefei National Research Center for Physical Sciences at the Microscale, MOE Key Laboratory for Membraneless Organelles & Cellular Dynamics, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Biomedical Sciences and Health Laboratory of Anhui Province, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China.
Chen J; Hefei National Research Center for Physical Sciences at the Microscale, MOE Key Laboratory for Membraneless Organelles & Cellular Dynamics, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Biomedical Sciences and Health Laboratory of Anhui Province, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China.
Li Y; Hefei National Research Center for Physical Sciences at the Microscale, MOE Key Laboratory for Membraneless Organelles & Cellular Dynamics, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Biomedical Sciences and Health Laboratory of Anhui Province, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China.
Ye J; Hefei National Research Center for Physical Sciences at the Microscale, MOE Key Laboratory for Membraneless Organelles & Cellular Dynamics, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Biomedical Sciences and Health Laboratory of Anhui Province, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China.; Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China.
Wang C; Hefei National Research Center for Physical Sciences at the Microscale, MOE Key Laboratory for Membraneless Organelles & Cellular Dynamics, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Biomedical Sciences and Health Laboratory of Anhui Province, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China.; Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Nov 30; Vol. 24 (23). Date of Electronic Publication: 2023 Nov 30.
Typ publikacji:
Journal Article
MeSH Terms:
Ankyrin Repeat*
Brain-Derived Neurotrophic Factor*/metabolism
Neurons/metabolism ; Mutagenesis ; Protein Binding ; Calcium/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Targeted mutagenesis of Medicago truncatula Nodule-specific Cysteine-Rich (NCR) genes using the Agrobacterium rhizogenes-mediated CRISPR/Cas9 system.
Autorzy:
Güngör B; Institute of Plant Biology, HUN-REN Biological Research Centre, Szeged, Hungary.; Institute of Genetics and Biotechnology, Hungarian University of Agriculture and Life Sciences, Gödöllő, Hungary.
Biró JB; Institute of Plant Biology, HUN-REN Biological Research Centre, Szeged, Hungary.
Domonkos Á; Institute of Genetics and Biotechnology, Hungarian University of Agriculture and Life Sciences, Gödöllő, Hungary.
Horváth B; Institute of Genetics and Biotechnology, Hungarian University of Agriculture and Life Sciences, Gödöllő, Hungary.
Kaló P; Institute of Plant Biology, HUN-REN Biological Research Centre, Szeged, Hungary. .; Institute of Genetics and Biotechnology, Hungarian University of Agriculture and Life Sciences, Gödöllő, Hungary. .
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Źródło:
Scientific reports [Sci Rep] 2023 Nov 24; Vol. 13 (1), pp. 20676. Date of Electronic Publication: 2023 Nov 24.
Typ publikacji:
Journal Article
MeSH Terms:
Medicago truncatula*/metabolism
Sinorhizobium meliloti*/genetics
Cysteine/metabolism ; CRISPR-Cas Systems/genetics ; Mutagenesis ; Peptides/metabolism ; Symbiosis/genetics ; Nitrogen Fixation/genetics ; Root Nodules, Plant/microbiology
SCR Organism:
Agrobacterium rhizogenes
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Epidemiological characteristics and therapeutic advances of EGFR exon 20 insertion mutations in non-small cell lung cancer.
Autorzy:
Pan B; Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Liang J; Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Shi H; Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Rao K; Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Guo W; Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.; Department of Thoracic Surgery and Urology, Shigatse People's Hospital, Shigatse, China.
Zhan C; Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
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Źródło:
Thoracic cancer [Thorac Cancer] 2023 Nov; Vol. 14 (33), pp. 3247-3258. Date of Electronic Publication: 2023 Oct 05.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*/drug therapy
Carcinoma, Non-Small-Cell Lung*/epidemiology
Carcinoma, Non-Small-Cell Lung*/genetics
Lung Neoplasms*/drug therapy
Lung Neoplasms*/epidemiology
Lung Neoplasms*/genetics
Humans ; Mutagenesis, Insertional ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Mutation ; ErbB Receptors ; Exons
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Hypermutation of specific genomic loci of Pseudomonas putida for continuous evolution of target genes.
Autorzy:
Velázquez E; Systems Biology Department, Centro Nacional de Biotecnología (CNB-CSIC), 28049, Madrid, Spain.
Álvarez B; Microbiology Department, Centro Nacional de Biotecnología (CNB-CSIC), 28049, Madrid, Spain.
Fernández LÁ; Microbiology Department, Centro Nacional de Biotecnología (CNB-CSIC), 28049, Madrid, Spain.
de Lorenzo V; Systems Biology Department, Centro Nacional de Biotecnología (CNB-CSIC), 28049, Madrid, Spain.
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Źródło:
Microbial biotechnology [Microb Biotechnol] 2022 Sep; Vol. 15 (9), pp. 2309-2323. Date of Electronic Publication: 2022 Jun 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Directed Molecular Evolution*/methods
Genes, Bacterial*
Mutagenesis*
Pseudomonas putida*/genetics
Cytosine/metabolism ; Cytosine Deaminase/genetics ; Cytosine Deaminase/metabolism ; DNA, Bacterial/genetics ; DNA-Directed RNA Polymerases/genetics ; DNA-Directed RNA Polymerases/metabolism ; Genetic Loci ; Genomics ; Mutation ; Plasmids/genetics ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Viral Proteins/genetics ; Viral Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Insight into de-regulation of amino acid feedback inhibition: a focus on structure analysis method.
Autorzy:
Naz S; Biodesign Center, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.
Liu P; Biodesign Center, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.
Farooq U; Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, Islamabad, 22060, Pakistan.
Ma H; Biodesign Center, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China. ma_.
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Źródło:
Microbial cell factories [Microb Cell Fact] 2023 Aug 23; Vol. 22 (1), pp. 161. Date of Electronic Publication: 2023 Aug 23.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Amino Acids*
Biotechnology*
Feedback ; Mutagenesis ; Mutation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Rapid selection of potyviral cross-protection effective mutants from the local lesion host after nitrous acid mutagenesis.
Autorzy:
Goh RP; Department of Plant Pathology, National Chung Hsing University, Taichung, Taiwan.
Xie XY; Department of Plant Pathology, National Chung Hsing University, Taichung, Taiwan.
Lin YC; Department of Plant Pathology, National Chung Hsing University, Taichung, Taiwan.
Cheng HW; Department of Plant Pathology, National Chung Hsing University, Taichung, Taiwan.; Advanced Plant Biotechnology Center, National Chung Hsing University, Taichung, Taiwan.
Raja JAJ; Department of Plant Pathology, National Chung Hsing University, Taichung, Taiwan.; Advanced Plant Biotechnology Center, National Chung Hsing University, Taichung, Taiwan.
Yeh SD; Department of Plant Pathology, National Chung Hsing University, Taichung, Taiwan.; Advanced Plant Biotechnology Center, National Chung Hsing University, Taichung, Taiwan.
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Źródło:
Molecular plant pathology [Mol Plant Pathol] 2023 Aug; Vol. 24 (8), pp. 973-988. Date of Electronic Publication: 2023 May 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Potyvirus*/genetics
Cucurbita*
Nitrous Acid ; Mutagenesis ; RNA Interference
SCR Organism:
Zucchini yellow mosaic virus
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A shifting mutational landscape in 6 nutritional states: Stress-induced mutagenesis as a series of distinct stress input-mutation output relationships.
Autorzy:
Maharjan RP; School of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia.
Ferenci T; School of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia.
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Źródło:
PLoS biology [PLoS Biol] 2017 Jun 08; Vol. 15 (6), pp. e2001477. Date of Electronic Publication: 2017 Jun 08 (Print Publication: 2017).
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
DNA, Bacterial*/metabolism
Gene-Environment Interaction*
Models, Genetic*
Mutagenesis*
Mutation*
Stress, Physiological*
Escherichia coli K12/*physiology
Carbohydrate Epimerases/genetics ; Carbohydrate Epimerases/metabolism ; Clone Cells ; Cluster Analysis ; Escherichia coli K12/genetics ; Escherichia coli K12/growth & development ; Escherichia coli K12/isolation & purification ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; Fermentation ; Gene Expression Profiling ; Gene Expression Regulation, Bacterial ; INDEL Mutation ; Mutagenesis, Insertional ; Mutation Rate ; Mutation, Missense ; Nutrigenomics/methods ; Point Mutation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Structural Insight into the Catalytic Mechanisms of an L‐Sorbosone Dehydrogenase.
Autorzy:
Li, Dong (AUTHOR)
Deng, Zhiwei (AUTHOR)
Hou, Xiaodong (AUTHOR)
Qin, Zhijie (AUTHOR)
Wang, Xinglong (AUTHOR)
Yin, Dejing (AUTHOR)
Chen, Yue (AUTHOR)
Rao, Yijian (AUTHOR)
Chen, Jian (AUTHOR)
Zhou, Jingwen (AUTHOR)
Pokaż więcej
Źródło:
Advanced Science. 10/26/2023, Vol. 10 Issue 30, p1-15. 15p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Design of a chimeric glycosyltransferase OleD for the site‐specific O‐monoglycosylation of 3‐hydroxypyridine in nosiheptide.
Autorzy:
Zhao, Ling (AUTHOR)
Xu, Yuncong (AUTHOR)
Chen, Manting (AUTHOR)
Wu, Lingrui (AUTHOR)
Li, Meng (AUTHOR)
Lu, Yuanyuan (AUTHOR)
Lu, Meiling (AUTHOR)
Chen, Yijun (AUTHOR)
Wu, Xuri (AUTHOR)
Pokaż więcej
Źródło:
Microbial Biotechnology. Oct2023, Vol. 16 Issue 10, p1971-1984. 14p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
DNA-bridging by an archaeal histone variant via a unique tetramerisation interface.
Autorzy:
Ofer, Sapir (AUTHOR)
Blombach, Fabian (AUTHOR)
Erkelens, Amanda M. (AUTHOR)
Barker, Declan (AUTHOR)
Soloviev, Zoja (AUTHOR)
Schwab, Samuel (AUTHOR)
Smollett, Katherine (AUTHOR)
Matelska, Dorota (AUTHOR)
Fouqueau, Thomas (AUTHOR)
van der Vis, Nico (AUTHOR)
Kent, Nicholas A. (AUTHOR)
Thalassinos, Konstantinos (AUTHOR)
Dame, Remus T. (AUTHOR)
Werner, Finn (AUTHOR)
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Źródło:
Communications Biology. 9/22/2023, Vol. 6 Issue 1, p1-16. 16p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Structural Similarities and Overlapping Activities among Dihydroflavonol 4-Reductase, Flavanone 4-Reductase, and Anthocyanidin Reductase Offer Metabolic Flexibility in the Flavonoid Pathway.
Autorzy:
Lewis, Jacob A. (AUTHOR)
Zhang, Bixia (AUTHOR)
Harza, Rishi (AUTHOR)
Palmer, Nathan (AUTHOR)
Sarath, Gautam (AUTHOR)
Sattler, Scott E. (AUTHOR)
Twigg, Paul (AUTHOR)
Vermerris, Wilfred (AUTHOR)
Kang, ChulHee (AUTHOR)
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Źródło:
International Journal of Molecular Sciences. Sep2023, Vol. 24 Issue 18, p13901. 30p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Celastrol Combats Methicillin‐Resistant Staphylococcus aureus by Targeting Δ‐Pyrroline‐5‐Carboxylate Dehydrogenase.
Autorzy:
Yuan, Zhongwei (AUTHOR)
Wang, Jun (AUTHOR)
Qu, Qianwei (AUTHOR)
Zhu, Zhenxin (AUTHOR)
Xu, Marc (AUTHOR)
Zhao, Mengmeng (AUTHOR)
Sun, Chongxiang (AUTHOR)
Peng, Haixin (AUTHOR)
Huang, Xingyu (AUTHOR)
Dong, Yue (AUTHOR)
Dong, Chunliu (AUTHOR)
Zheng, Yadan (AUTHOR)
Yuan, Shuguang (AUTHOR)
Li, Yanhua (AUTHOR)
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Źródło:
Advanced Science. 9/5/2023, Vol. 10 Issue 25, p1-20. 20p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Beyond rational—biosensor-guided isolation of 100 independently evolved bacterial strain variants and comparative analysis of their genomes.
Autorzy:
Baumann, Philipp T. (AUTHOR)
Dal Molin, Michael (AUTHOR)
Aring, Hannah (AUTHOR)
Krumbach, Karin (AUTHOR)
Müller, Moritz-Fabian (AUTHOR)
Vroling, Bas (AUTHOR)
van Summeren-Wesenhagen, Philana V. (AUTHOR)
Noack, Stephan (AUTHOR)
Marienhagen, Jan (AUTHOR)
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Źródło:
BMC Biology. 9/4/2023, Vol. 21 Issue 1, p1-18. 18p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Site-directed mutagenesis in Cry proteins of Bacillusthuringiensis to demonstrate the role of domain II and domain III in toxicity enhancement toward Spodopteralitura.
Autorzy:
Khurshid, Huma (AUTHOR)
Zaheer, Hafsa (AUTHOR)
Yunus, Fakhar-un-Nisa (AUTHOR)
Manzoor, Farkhanda (AUTHOR)
Latif, Aasma Abdul (AUTHOR)
Rashid, Farzana (AUTHOR)
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Źródło:
Egyptian Journal of Biological Pest Control. 8/30/2023, Vol. 33 Issue 1, p1-9. 9p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Molecular modelling and site-directed mutagenesis provide insight into saccharide pyruvylation by the Paenibacillus alvei CsaB enzyme.
Autorzy:
Stefanović, Cordula (AUTHOR)
Hager-Mair, Fiona F. (AUTHOR)
Breslmayr, Erik (AUTHOR)
López-Guzmán, Arturo (AUTHOR)
Lim, Charlie (AUTHOR)
Blaukopf, Markus (AUTHOR)
Kosma, Paul (AUTHOR)
Oostenbrink, Chris (AUTHOR)
Ludwig, Roland (AUTHOR)
Schäffer, Christina (AUTHOR)
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Źródło:
Scientific Reports. 8/17/2023, Vol. 13 Issue 1, p1-13. 13p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 61-80 z 93530

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