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Tytuł:
Meiotic DNA breaks drive multifaceted mutagenesis in the human germ line.
Autorzy:
Hinch R; Big Data Institute, University of Oxford, Oxford, UK.
Donnelly P; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Genomics plc, Oxford, UK.
Hinch AG; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Dec; Vol. 382 (6674), pp. eadh2531. Date of Electronic Publication: 2023 Dec 01.
Typ publikacji:
Journal Article
MeSH Terms:
DNA Breaks, Double-Stranded*
DNA Repair*
Genome, Human*
Meiosis*/genetics
Mutagenesis*
Recombination, Genetic*
Humans ; Male ; Mutation ; Ovum/metabolism ; Semen/metabolism ; Translesion DNA Synthesis ; Female
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Genome editing with retroelements.
Autorzy:
Tang S; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Sternberg SH; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Oct 27; Vol. 382 (6669), pp. 370-371. Date of Electronic Publication: 2023 Oct 26.
Typ publikacji:
Journal Article
MeSH Terms:
Gene Editing*/methods
Retroelements*
RNA, Guide, CRISPR-Cas Systems*/chemistry
Mutagenesis, Insertional*/methods
CRISPR-Associated Protein 9*/chemistry
CRISPR-Cas Systems ; Genome, Human ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Evelyn M. Witkin (1921-2023).
Autorzy:
Sweasy JB; The University of Arizona Comprehensive Cancer Center, Tucson, AZ, USA.
Hanawalt PC; Department of Biology, Stanford University, Stanford, CA, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Sep 08; Vol. 381 (6662), pp. 1052. Date of Electronic Publication: 2023 Sep 07.
Typ publikacji:
Journal Article
MeSH Terms:
DNA Repair*
Genetics*/history
Mutagenesis*
United States
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Enhancement of protein thermostability by three consecutive mutations using loop-walking method and machine learning.
Autorzy:
Yoshida K; Innovation Center, Amano Enzyme Inc., Technoplaza, Kakamigahara, Gifu, 509-0109, Japan.; Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University, Tsushima, Okayama, 700-8530, Japan.
Kawai S; Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Nagoya, 464-8601, Japan.
Fujitani M; Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Nagoya, 464-8601, Japan.
Koikeda S; Innovation Center, Amano Enzyme Inc., Technoplaza, Kakamigahara, Gifu, 509-0109, Japan. satoshi_.
Kato R; Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Nagoya, 464-8601, Japan. .
Ema T; Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University, Tsushima, Okayama, 700-8530, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2021 Jun 04; Vol. 11 (1), pp. 11883. Date of Electronic Publication: 2021 Jun 04.
Typ publikacji:
Journal Article
MeSH Terms:
Enzyme Stability*
Machine Learning*
Mutagenesis*
Mutation*
Burkholderia cepacia/*genetics
Lipase/*chemistry
Protein Engineering/*methods
Proteins/*chemistry
Proteins/*genetics
Computational Biology ; Escherichia coli/metabolism ; Hot Temperature ; Hydrolases/chemistry ; Kinetics ; Molecular Conformation ; Molecular Dynamics Simulation ; Mutagenesis, Site-Directed ; Plasmids/metabolism ; Polymerase Chain Reaction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Creation of Golden Gate constructs for gene doctoring.
Autorzy:
Thomson NM; Quadram Institute Bioscience, Norwich Research Park, Norwich, Norfolk, NR4 7UQ, UK.
Zhang C; Quadram Institute Bioscience, Norwich Research Park, Norwich, Norfolk, NR4 7UQ, UK.; National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.; Guangdong Key Laboratory for Veterinary Drug Development and Safety evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.
Trampari E; Quadram Institute Bioscience, Norwich Research Park, Norwich, Norfolk, NR4 7UQ, UK.
Pallen MJ; Quadram Institute Bioscience, Norwich Research Park, Norwich, Norfolk, NR4 7UQ, UK. .; School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, Norfolk, NR4 7TU, UK. .; School of Veterinary Medicine, University of Surrey, Daphne Jackson Road, Guildford, Surrey, GU2 7AL, UK. .
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Źródło:
BMC biotechnology [BMC Biotechnol] 2020 Oct 07; Vol. 20 (1), pp. 54. Date of Electronic Publication: 2020 Oct 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genetic Engineering*
Mutagenesis*
Bacteria ; Chromosomes ; DNA ; Enterobacteriaceae ; Escherichia coli/genetics ; Gene Deletion ; Gene Editing ; Genetic Vectors ; Mutagenesis, Insertional ; Plasmids ; Whole Genome Sequencing
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A guide to barley mutants.
Autorzy:
Hansson M; Department of Biology, Lund University, Sölvegatan 35, 22362, Lund, Sweden. .
Youssef HM; Faculty of Agriculture, Cairo University, Giza, 12613, Egypt.; Institute of Agricultural and Nutritional Sciences, Faculty of Natural Sciences III, Martin Luther University Halle-Wittenberg, Halle, 06120, Germany.
Zakhrabekova S; Department of Biology, Lund University, Sölvegatan 35, 22362, Lund, Sweden.
Stuart D; Department of Biology, Lund University, Sölvegatan 35, 22362, Lund, Sweden.
Svensson JT; Nordic Genetic Resource Center (NordGen), Växthusvägen 12, 23456, Alnarp, Sweden.
Dockter C; Carlsberg Research Laboratory, J. C. Jacobsens Gade 4, 1799, Copenhagen V, Denmark.
Stein N; Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), OT Gatersleben, Stadt Seeland, E06466, Germany.; Center for Integrated Breeding Research (CiBreed), Georg-August-University, Göttingen, Germany.
Waugh R; Cell and Molecular Sciences, The James Hutton Institute, Invergowrie, Dundee, DD2 5DA, UK.; Division of Plant Sciences, University of Dundee, The James Hutton Institute, Invergowrie, Dundee, DD2 5DA, UK.; School of Agriculture Food and Wine, Waite Campus, The University of Adelaide, Urrbrae, 5064, Australia.
Lundqvist U; Nordic Genetic Resource Center (NordGen), Växthusvägen 12, 23456, Alnarp, Sweden.
Franckowiak J; Department of Agronomy and Plant Genetics, University of Minnesota Twin Cities, 411 Borlaug Hall, 1991 Upper Buford Circle, St Paul, MN, 55108, USA.
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Źródło:
Hereditas [Hereditas] 2024 Mar 08; Vol. 161 (1), pp. 11. Date of Electronic Publication: 2024 Mar 08.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Hordeum*/genetics
Plant Breeding ; Mutagenesis ; Genomics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Genomics of predictive radiation mutagenesis in oilseed rape: modifying seed oil composition.
Autorzy:
Havlickova L; Department of Biology, University of York, York, UK.
He Z; Department of Biology, University of York, York, UK.
Berger M; Department of Biology, University of York, York, UK.
Wang L; Department of Biology, University of York, York, UK.
Sandmann G; Department of Biology, University of York, York, UK.
Chew YP; Department of Biology, University of York, York, UK.
Yoshikawa GV; Department of Biology, University of York, York, UK.
Lu G; Department of Rapeseed Genetics and Breeding, Oil Crops Research Institute, CAAS, Wuhan, China.; College of Biology and Food Engineering, Guangdong University of Petrochemical Technology, Maoming, China.
Hu Q; Department of Rapeseed Genetics and Breeding, Oil Crops Research Institute, CAAS, Wuhan, China.
Banga SS; Department of Plant Breeding and Genetics, Punjab Agricultural University, Ludhiana, India.
Beaudoin F; Plant Sciences for the Bioeconomy, Rothamsted Research, Harpenden, UK.
Bancroft I; Department of Biology, University of York, York, UK.
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Źródło:
Plant biotechnology journal [Plant Biotechnol J] 2024 Mar; Vol. 22 (3), pp. 738-750. Date of Electronic Publication: 2023 Nov 03.
Typ publikacji:
Journal Article
MeSH Terms:
Brassica napus*/genetics
Brassica rapa*/genetics
Plant Breeding ; Genomics ; Mutagenesis/genetics ; Seeds/genetics ; Plant Oils
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The cycad genotoxin methylazoxymethanol, linked to Guam ALS/PDC, induces transcriptional mutagenesis.
Autorzy:
Verheijen BM; School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA. .; Department of Neuroscience, Maastricht University, Maastricht, The Netherlands. .
Chung C; School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA.
Thompson B; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
Kim H; Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Nakahara A; Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan.
Anink JJ; Department of Neuropathology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Mills JD; Department of Neuropathology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Department of Clinical and Experimental Epilepsy, University College London Queen Square Institute of Neurology, London, WC1N 3BG, UK.; Chalfont Centre for Epilepsy, Chalfont St Peter, SL9 0RJ, UK.
Lee JH; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
Aronica E; Department of Neuropathology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Oyanagi K; Division of Neuropathology, Department of Brain Disease Research, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
Kakita A; Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan.
Gout JF; Department of Biological Sciences, Mississippi State University, Mississippi State, MS, 39762, USA.
Vermulst M; School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA.
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Corporate Authors:
NYGC ALS Consortium
Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Feb 21; Vol. 12 (1), pp. 30. Date of Electronic Publication: 2024 Feb 21.
Typ publikacji:
Letter
MeSH Terms:
Mutagens*
Amyotrophic Lateral Sclerosis*/genetics
Methylazoxymethanol Acetate/*analogs & derivatives
Humans ; Guam ; Mutagenesis
Opinia redakcyjna
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Enhancing cold resistance in Banana (Musa spp.) through EMS-induced mutagenesis, L-Hyp pressure selection: phenotypic alterations, biomass composition, and transcriptomic insights.
Autorzy:
Liu Y; National Key Laboratory for Tropical Crop Breeding, Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Sanya/Haikou, Hainan, 572024/571101, China.; College of Plant Science & Technology, Huazhong Agricultural University, Wuhan, 430070, China.
Li Y; National Key Laboratory for Tropical Crop Breeding, Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Sanya/Haikou, Hainan, 572024/571101, China.; Hainan Banana Healthy Seedling Propagation Engineering Research Center, Haikou Experimental Station, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, Hainan, China.
Wang A; National Key Laboratory for Tropical Crop Breeding, Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Sanya/Haikou, Hainan, 572024/571101, China.; Hainan Banana Healthy Seedling Propagation Engineering Research Center, Haikou Experimental Station, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, Hainan, China.
Xu Z; Hainan Banana Healthy Seedling Propagation Engineering Research Center, Haikou Experimental Station, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, Hainan, China.; College of Horticulture, Hainan University, Haikou, 571101, Hainan, China.
Li C; Collage of Tropical Crop, Yunnan Agricultural University, Puer, 611101, Yunnan, China.
Wang Z; Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, Hainan, China.
Guo B; National Key Laboratory for Tropical Crop Breeding, Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Sanya/Haikou, Hainan, 572024/571101, China.; College of Plant Science & Technology, Huazhong Agricultural University, Wuhan, 430070, China.
Chen Y; Collage of Tropical Crop, Yunnan Agricultural University, Puer, 611101, Yunnan, China.
Tang F; National Key Laboratory for Tropical Crop Breeding, Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Sanya/Haikou, Hainan, 572024/571101, China.; Hainan Banana Healthy Seedling Propagation Engineering Research Center, Haikou Experimental Station, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, Hainan, China.
Li J; National Key Laboratory for Tropical Crop Breeding, Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Sanya/Haikou, Hainan, 572024/571101, China. .; Hainan Banana Healthy Seedling Propagation Engineering Research Center, Haikou Experimental Station, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, Hainan, China. .
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Źródło:
BMC plant biology [BMC Plant Biol] 2024 Feb 09; Vol. 24 (1), pp. 101. Date of Electronic Publication: 2024 Feb 09.
Typ publikacji:
Journal Article
MeSH Terms:
Musa*/metabolism
Ethyl Methanesulfonate/metabolism ; Ethyl Methanesulfonate/pharmacology ; Biomass ; Gene Expression Profiling ; Mutagenesis ; Phenotype ; Cold Temperature ; Gene Expression Regulation, Plant
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Identification of 6-methyladenosine sites using novel feature encoding methods and ensemble models.
Autorzy:
Alromema, Nashwan (AUTHOR)
Suleman, Muhammad Taseer (AUTHOR)
Malebary, Sharaf J. (AUTHOR)
Ahmed, Amir (AUTHOR)
Ali Mohammed Al-Rami Al-Ghamdi, Bandar (AUTHOR)
Khan, Yaser Daanial (AUTHOR)
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Źródło:
Scientific Reports. 4/11/2024, Vol. 14 Issue 1, p1-13. 13p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A Combination of Library Screening and Rational Mutagenesis Expands the Available Color Palette of the Smallest Fluorogen-Activating Protein Tag nanoFAST.
Autorzy:
Baleeva, Nadezhda S. (AUTHOR)
Bogdanova, Yulia A. (AUTHOR)
Goncharuk, Marina V. (AUTHOR)
Sokolov, Anatolii I. (AUTHOR)
Myasnyanko, Ivan N. (AUTHOR)
Kublitski, Vadim S. (AUTHOR)
Smirnov, Alexander Yu. (AUTHOR)
Gilvanov, Aidar R. (AUTHOR)
Goncharuk, Sergey A. (AUTHOR)
Mineev, Konstantin S. (AUTHOR)
Baranov, Mikhail S. (AUTHOR)
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Źródło:
International Journal of Molecular Sciences. Mar2024, Vol. 25 Issue 5, p3054. 14p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
RNA three-dimensional structure drives the sequence organization of potato spindle tuber viroid quasispecies.
Autorzy:
Wu J; State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agroproducts, Institute of Plant Virology, Ningbo University, Ningbo, China.; Key Laboratory of Biotechnology in Plant Protection of MARA and Zhejiang Province, Institute of Plant Virology, Ningbo University, Ningbo, China.; Department of Molecular Genetics, Center for Applied Plant Sciences, Center for RNA Biology, and Infectious Diseases Institute, The Ohio State University, Columbus, Ohio, United States of America.
Zhang Y; State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agroproducts, Institute of Plant Virology, Ningbo University, Ningbo, China.; Key Laboratory of Biotechnology in Plant Protection of MARA and Zhejiang Province, Institute of Plant Virology, Ningbo University, Ningbo, China.
Nie Y; State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agroproducts, Institute of Plant Virology, Ningbo University, Ningbo, China.; Key Laboratory of Biotechnology in Plant Protection of MARA and Zhejiang Province, Institute of Plant Virology, Ningbo University, Ningbo, China.
Yan F; State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agroproducts, Institute of Plant Virology, Ningbo University, Ningbo, China.; Key Laboratory of Biotechnology in Plant Protection of MARA and Zhejiang Province, Institute of Plant Virology, Ningbo University, Ningbo, China.
Zirbel CL; Department of Mathematics and Statistics, Bowling Green State University, Bowling Green, Ohio, United States of America.
Bisaro DM; Department of Molecular Genetics, Center for Applied Plant Sciences, Center for RNA Biology, and Infectious Diseases Institute, The Ohio State University, Columbus, Ohio, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2024 Apr 04; Vol. 20 (4), pp. e1012142. Date of Electronic Publication: 2024 Apr 04 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Viroids*/genetics
Solanum tuberosum*/genetics
Plant Viruses*/genetics
RNA, Viral/genetics ; RNA, Viral/chemistry ; Quasispecies ; Mutagenesis ; Plant Diseases
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Application of CRISPR/Cas9 for targeted mutagenesis in teosinte Zea mays ssp. parviglumis.
Autorzy:
Zobrist JD; Department of Agronomy, Iowa State University, Ames, Iowa, USA.; Crop Bioengineering Center, Iowa State University, Ames, Iowa, USA.; Interdepartmental Genetics and Genomics Major, Iowa State University, Ames, Iowa, USA.
Lee K; Department of Agronomy, Iowa State University, Ames, Iowa, USA.; Crop Bioengineering Center, Iowa State University, Ames, Iowa, USA.
Wang K; Department of Agronomy, Iowa State University, Ames, Iowa, USA.; Crop Bioengineering Center, Iowa State University, Ames, Iowa, USA.
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Źródło:
Plant biotechnology journal [Plant Biotechnol J] 2024 Apr; Vol. 22 (4), pp. 796-798. Date of Electronic Publication: 2023 Dec 12.
Typ publikacji:
Journal Article
MeSH Terms:
Zea mays*/genetics
CRISPR-Cas Systems*/genetics
Chromosome Mapping ; Mutagenesis/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The evolutionary safety of mutagenic drugs should be assessed before drug approval.
Autorzy:
Lobinska G; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Tretyachenko V; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Dahan O; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Nowak MA; Department of Mathematics & Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America.
Pilpel Y; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
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Źródło:
PLoS biology [PLoS Biol] 2024 Mar 15; Vol. 22 (3), pp. e3002570. Date of Electronic Publication: 2024 Mar 15 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Drug Approval*
Mutagens*/toxicity
Mutagenesis ; Mutation Rate ; Phenotype
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Mutagenic Plasticity of the Cholera Toxin B-Subunit Surface Residues: Stability and Affinity.
Autorzy:
Au CW; School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK.
Manfield I; School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK.; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK.
Webb ME; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK.; School of Chemistry, University of Leeds, Leeds LS2 9JT, UK.
Paci E; Dipartimento di Fisica e Astronomia 'Augusto Righi', Viale Berti Pichat 6/2, 40127 Bologna, Italy.
Turnbull WB; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK.; School of Chemistry, University of Leeds, Leeds LS2 9JT, UK.
Ross JF; School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK.; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK.
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Źródło:
Toxins [Toxins (Basel)] 2024 Mar 04; Vol. 16 (3). Date of Electronic Publication: 2024 Mar 04.
Typ publikacji:
Journal Article
MeSH Terms:
Mutagens*
Cholera Toxin*
Humans ; G(M1) Ganglioside ; Ligands ; Mutagenesis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
CRISPR-mediated germline mutagenesis for genetic sterilization of Anopheles gambiae males.
Autorzy:
Smidler AL; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.; Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA.; Department of Biology, University of California - San Diego, San Diego, CA, 92093, USA.
Marrogi E; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
Kauffman J; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
Paton DG; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.; Department of Infectious Diseases, University of Georgia, Athens, GA, 30602, USA.
Westervelt KA; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
Church GM; Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA.
Esvelt KM; Media Lab, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Shaw WR; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA. .; Howard Hughes Medical Institute, Chevy Chase, MD, 20815, USA. .
Catteruccia F; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA. .; Howard Hughes Medical Institute, Chevy Chase, MD, 20815, USA. .
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Źródło:
Scientific reports [Sci Rep] 2024 Feb 19; Vol. 14 (1), pp. 4057. Date of Electronic Publication: 2024 Feb 19.
Typ publikacji:
Journal Article
MeSH Terms:
Anopheles*/genetics
Infertility, Male*/genetics
Malaria*
Humans ; Animals ; Male ; Female ; Mosquito Control/methods ; Mosquito Vectors/genetics ; Semen ; RNA, Guide, CRISPR-Cas Systems ; Mutagenesis ; Germ Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Tyrosine Sulfation at Antibody Light Chain CDR-1 Increases Binding Affinity and Neutralization Potency to Interleukine-4.
Autorzy:
D'Antona AM; BioMedicine Design, Pfizer Research & Development, 610 Main Street, Cambridge, MA 02139, USA.
Lee JM; Translational Clinical Sciences, Pfizer Discovery & Early Development, 610 Main Street, Cambridge, MA 02139, USA.
Zhang M; Inflammation and Immunology Research Unit, Pfizer Research & Development, 610 Main Street, Cambridge, MA 02139, USA.
Friedman C; BioMedicine Design, Pfizer Research & Development, 610 Main Street, Cambridge, MA 02139, USA.
He T; BioMedicine Design, Pfizer Research & Development, 610 Main Street, Cambridge, MA 02139, USA.
Mosyak L; BioMedicine Design, Pfizer Research & Development, 610 Main Street, Cambridge, MA 02139, USA.
Bennett E; BioMedicine Design, Pfizer Research & Development, 610 Main Street, Cambridge, MA 02139, USA.
Lin L; BioMedicine Design, Pfizer Research & Development, 610 Main Street, Cambridge, MA 02139, USA.
Silverman M; BioMedicine Design, Pfizer Research & Development, 610 Main Street, Cambridge, MA 02139, USA.
Cometa F; BioMedicine Design, Pfizer Research & Development, 610 Main Street, Cambridge, MA 02139, USA.
Meade C; BioMedicine Design, Pfizer Research & Development, 610 Main Street, Cambridge, MA 02139, USA.
Hageman T; BioMedicine Design, Pfizer Research & Development, 610 Main Street, Cambridge, MA 02139, USA.
Sousa E; BioMedicine Design, Pfizer Research & Development, 610 Main Street, Cambridge, MA 02139, USA.
Cohen J; BioMedicine Design, Pfizer Research & Development, 610 Main Street, Cambridge, MA 02139, USA.
Marquette K; BioMedicine Design, Pfizer Research & Development, 610 Main Street, Cambridge, MA 02139, USA.
Ferguson D; BioMedicine Design, Pfizer Research & Development, 610 Main Street, Cambridge, MA 02139, USA.
Zhong X; BioMedicine Design, Pfizer Research & Development, 610 Main Street, Cambridge, MA 02139, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 05; Vol. 25 (3). Date of Electronic Publication: 2024 Feb 05.
Typ publikacji:
Journal Article
MeSH Terms:
Tyrosine*/metabolism
Interleukin-4*
Humans ; HEK293 Cells ; Golgi Apparatus/metabolism ; Mutagenesis
Czasopismo naukowe
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