Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""Mutant"" wg kryterium: Temat


Tytuł :
Low-frequency collective motion of DNA-binding domain defines p53 function.
Autorzy :
Zhang G; CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China.; Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.
Tang C; CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China.; Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.
Pan L; School of Mechatronical Engineering, Beijing Institute of Technology, Beijing, China.
Lü J; CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China.; Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, China.
Pokaż więcej
Źródło :
Proteins [Proteins] 2022 Mar; Vol. 90 (3), pp. 881-888. Date of Electronic Publication: 2021 Nov 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutant Proteins/*chemistry
Tumor Suppressor Protein p53/*chemistry
Amino Acid Sequence ; Binding Sites ; DNA/chemistry ; Humans ; Models, Molecular ; Mutant Proteins/genetics ; Mutation ; Protein Binding ; Protein Domains ; Structure-Activity Relationship ; Tumor Suppressor Protein p53/genetics
Czasopismo naukowe
Tytuł :
Molecular insights on the conformational dynamics of a P76C mutant of human cytochrome c and the enhancement on its peroxidase activity.
Autorzy :
Samsri S; Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand.
Prasertsuk P; Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand.
Nutho B; Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand. Electronic address: .
Pornsuwan S; Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand. Electronic address: .
Pokaż więcej
Źródło :
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2022 Feb 15; Vol. 716, pp. 109112. Date of Electronic Publication: 2021 Dec 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytochromes c/*metabolism
Mutant Proteins/*metabolism
Peroxidases/*metabolism
Amino Acid Sequence ; Cardiolipins/metabolism ; Cysteine/chemistry ; Cytochromes c/genetics ; Enzyme Activation ; Heme/metabolism ; Humans ; Molecular Dynamics Simulation ; Mutant Proteins/genetics ; Mutation ; Protein Conformation ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Computational prediction of intracellular targets of wild-type or mutant vesicular stomatitis matrix protein.
Autorzy :
Morris MC; Center for Clinical Systems Biology, Rochester General Hospital, Rochester, NY, United States of America.
Russell TM; Thomas Gosnell School of Life Sciences, Rochester Institute of Technology, Rochester, NY, United States of America.
Lyman CA; Center for Clinical Systems Biology, Rochester General Hospital, Rochester, NY, United States of America.
Wong WK; Thomas Gosnell School of Life Sciences, Rochester Institute of Technology, Rochester, NY, United States of America.
Broderick G; Center for Clinical Systems Biology, Rochester General Hospital, Rochester, NY, United States of America.
Ferran MC; Thomas Gosnell School of Life Sciences, Rochester Institute of Technology, Rochester, NY, United States of America.
Pokaż więcej
Źródło :
PloS one [PLoS One] 2022 Feb 02; Vol. 17 (2), pp. e0263065. Date of Electronic Publication: 2022 Feb 02 (Print Publication: 2022).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Transcriptome*
Computational Biology/*methods
Fibroblasts/*metabolism
Mutant Proteins/*metabolism
NF-kappa B/*metabolism
Vesicular Stomatitis/*metabolism
Viral Matrix Proteins/*metabolism
Animals ; Fibroblasts/virology ; Interferon Type I/metabolism ; Mice ; Mutant Proteins/genetics ; NF-kappa B/genetics ; Vesicular Stomatitis/genetics ; Vesicular Stomatitis/virology ; Vesicular stomatitis Indiana virus/physiology ; Viral Matrix Proteins/genetics
Czasopismo naukowe
Tytuł :
The E2 ubiquitin-conjugating enzyme HIP2 is a crucial regulator of quality control against mutant SOD1 proteotoxicity.
Autorzy :
Tak YJ; Division of Life Sciences, Korea University, Seoul 02841, Republic of Korea.
Kang S; Division of Life Sciences, Korea University, Seoul 02841, Republic of Korea. Electronic address: .
Pokaż więcej
Źródło :
Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2022 Feb 01; Vol. 1868 (2), pp. 166316. Date of Electronic Publication: 2021 Nov 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Motor Neurons/*pathology
Mutant Proteins/*metabolism
Superoxide Dismutase-1/*metabolism
Ubiquitin/*metabolism
Ubiquitin-Conjugating Enzymes/*metabolism
Animals ; Female ; HEK293 Cells ; Humans ; Male ; Mice ; Mice, Transgenic ; Motor Neurons/metabolism ; Mutant Proteins/genetics ; Quality Control ; Superoxide Dismutase-1/genetics ; Ubiquitin-Conjugating Enzymes/genetics ; Ubiquitination
Czasopismo naukowe
Tytuł :
The effects of mutation on the drug binding affinity of Neuraminidase: case study of Capsaicin using steered molecular dynamics simulation.
Autorzy :
Sedighpour D; Faculty of Biomedical Engineering, Sahand University of Technology, Sahand, Tabriz, Iran.
Taghizadeh H; Tissue Mechanics Lab, Faculty of Biomedical Engineering, Sahand University of Technology, PO. BOX 51335/1996, Tabriz, Iran. .
Pokaż więcej
Źródło :
Journal of molecular modeling [J Mol Model] 2022 Jan 13; Vol. 28 (2), pp. 36. Date of Electronic Publication: 2022 Jan 13.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Docking Simulation*
Molecular Dynamics Simulation*
Capsaicin/*chemistry
Enzyme Inhibitors/*chemistry
Mutant Proteins/*chemistry
Neuraminidase/*chemistry
Amino Acid Substitution ; Binding Sites ; Capsaicin/pharmacology ; Enzyme Inhibitors/pharmacology ; Humans ; Ligands ; Molecular Conformation ; Mutant Proteins/antagonists & inhibitors ; Mutant Proteins/genetics ; Neuraminidase/antagonists & inhibitors ; Neuraminidase/genetics ; Protein Binding ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Molecular dynamics study of enhanced autophosphorylation by S904F mutation of the RET kinase domain.
Autorzy :
Chen YJ; Institute of Precision Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan.
Li PY; Department of Life Sciences, National University of Kaohsiung, Kaohsiung, Taiwan.
Yang CN; Institute of Precision Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan. Electronic address: .
Pokaż więcej
Źródło :
Journal of structural biology [J Struct Biol] 2021 Dec; Vol. 213 (4), pp. 107799. Date of Electronic Publication: 2021 Sep 23.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Dynamics Simulation*
Mutation*
Mutant Proteins/*genetics
Proto-Oncogene Proteins c-ret/*genetics
Adenosine Triphosphate/chemistry ; Adenosine Triphosphate/metabolism ; Algorithms ; Binding Sites/genetics ; Humans ; Kinetics ; Molecular Structure ; Mutant Proteins/chemistry ; Mutant Proteins/metabolism ; Phosphorylation ; Protein Binding ; Protein Domains ; Protein Stability ; Proto-Oncogene Proteins c-ret/chemistry ; Proto-Oncogene Proteins c-ret/metabolism ; Thermodynamics
Czasopismo naukowe
Tytuł :
A protective vaccine against the toxic activities following Brown spider accidents based on recombinant mutated phospholipases D as antigens.
Autorzy :
Polli NLC; Department of Cell Biology, Federal University of Paraná (UFPR), Curitiba 81530-900, PR, Brazil.
Justa HCD; Department of Cell Biology, Federal University of Paraná (UFPR), Curitiba 81530-900, PR, Brazil.
Antunes BC; Department of Cell Biology, Federal University of Paraná (UFPR), Curitiba 81530-900, PR, Brazil; Production and Research Center of Immunobiological Products (CPPI), State Department of Health, Piraquara 83302-200, PR, Brazil.
Silva TPD; Department of Cell Biology, Federal University of Paraná (UFPR), Curitiba 81530-900, PR, Brazil.
Dittrich RL; Veterinary Hospital, Federal University of Paraná (UFPR), Curitiba 80035-050, PR, Brazil.
de Souza GS; Veterinary Hospital, Federal University of Paraná (UFPR), Curitiba 80035-050, PR, Brazil.
Wille ACM; Department of Structural, Molecular Biology and Genetics, State University of Ponta Grossa (UEPG), Ponta Grossa 84030-900, PR, Brazil.
Matsubara FH; Department of Cell Biology, Federal University of Paraná (UFPR), Curitiba 81530-900, PR, Brazil.
Minozzo JC; Multiuser Center for Biomolecular Innovation, Departament of Physics, Universidade Estadual Paulista (UNESP), São José do Rio Preto 15054-000, SP, Brazil.
Mariutti RB; Multiuser Center for Biomolecular Innovation, Departament of Physics, Universidade Estadual Paulista (UNESP), São José do Rio Preto 15054-000, SP, Brazil.
Arni RK; Multiuser Center for Biomolecular Innovation, Departament of Physics, Universidade Estadual Paulista (UNESP), São José do Rio Preto 15054-000, SP, Brazil.
Senff-Ribeiro A; Department of Cell Biology, Federal University of Paraná (UFPR), Curitiba 81530-900, PR, Brazil.
Veiga SS; Department of Cell Biology, Federal University of Paraná (UFPR), Curitiba 81530-900, PR, Brazil.
Gremski LH; Department of Cell Biology, Federal University of Paraná (UFPR), Curitiba 81530-900, PR, Brazil. Electronic address: .
Pokaż więcej
Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Dec 01; Vol. 192, pp. 757-770. Date of Electronic Publication: 2021 Oct 09.
Typ publikacji :
Journal Article
MeSH Terms :
Brown Recluse Spider*
Mutant Proteins/*immunology
Phospholipase D/*immunology
Spider Bites/*immunology
Spider Bites/*therapy
Vaccines/*immunology
Accidents ; Animals ; Antibodies, Neutralizing/blood ; Antibodies, Neutralizing/immunology ; Antivenins/blood ; Antivenins/immunology ; Biomarkers ; Disease Models, Animal ; Immunogenicity, Vaccine ; Leukocyte Count ; Mice ; Models, Molecular ; Mutant Proteins/chemistry ; Mutant Proteins/genetics ; Neutralization Tests ; Phospholipase D/chemistry ; Phospholipase D/genetics ; Rabbits ; Spider Bites/diagnosis ; Spider Bites/prevention & control ; Spider Venoms/immunology ; Structure-Activity Relationship ; Treatment Outcome ; Vaccination ; Vaccines/administration & dosage
Czasopismo naukowe
Tytuł :
Redox Sensitive Cysteine Residues as Crucial Regulators of Wild-Type and Mutant p53 Isoforms.
Autorzy :
Butturini E; Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biochemistry, University of Verona, 37134 Verona, Italy.
Butera G; Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biochemistry, University of Verona, 37134 Verona, Italy.
Pacchiana R; Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biochemistry, University of Verona, 37134 Verona, Italy.
Carcereri de Prati A; Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biochemistry, University of Verona, 37134 Verona, Italy.
Mariotto S; Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biochemistry, University of Verona, 37134 Verona, Italy.
Donadelli M; Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biochemistry, University of Verona, 37134 Verona, Italy.
Pokaż więcej
Źródło :
Cells [Cells] 2021 Nov 12; Vol. 10 (11). Date of Electronic Publication: 2021 Nov 12.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cysteine/*metabolism
Mutant Proteins/*chemistry
Tumor Suppressor Protein p53/*chemistry
Tumor Suppressor Protein p53/*metabolism
Animals ; Humans ; Mutant Proteins/metabolism ; Oxidation-Reduction ; Protein Isoforms/chemistry ; Protein Isoforms/metabolism ; Protein Processing, Post-Translational ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
The biochemical association between R157H mutation in human αB-crystallin and development of cardiomyopathy: Structural and functional analyses of the mutant protein.
Autorzy :
Nasiri P; Protein Chemistry Laboratory (PCL), Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran.
Ghahramani M; Protein Chemistry Laboratory (PCL), Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran.
Tavaf Z; Protein Chemistry Laboratory (PCL), Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran.
Niazi A; Institute of Biotechnology, Shiraz University, Shiraz, Iran.
Moosavi-Movahedi AA; Institute of Biochemistry and Biophysics (IBB), The University of Tehran, Tehran, Iran.
Kurganov BI; Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, 33, Bld. 2 Leninsky Ave., Moscow 119071, Russia.
Yousefi R; Protein Chemistry Laboratory (PCL), Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran. Electronic address: .
Pokaż więcej
Źródło :
Biochimie [Biochimie] 2021 Nov; Vol. 190, pp. 36-49. Date of Electronic Publication: 2021 Jul 05.
Typ publikacji :
Journal Article
MeSH Terms :
Cardiomyopathies/*genetics
Mutant Proteins/*chemistry
Mutant Proteins/*metabolism
alpha-Crystallin B Chain/*chemistry
alpha-Crystallin B Chain/*genetics
Amyloid/metabolism ; Circular Dichroism ; Dynamic Light Scattering ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Humans ; Molecular Chaperones/metabolism ; Mutagenesis, Site-Directed ; Mutant Proteins/genetics ; Point Mutation ; Protein Conformation ; Protein Folding ; Protein Stability ; Proteolysis ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Spectrometry, Fluorescence ; Spectroscopy, Fourier Transform Infrared ; Spectrum Analysis, Raman ; Temperature ; alpha-Crystallin B Chain/metabolism
Czasopismo naukowe
Tytuł :
WDR37 syndrome: identification of a distinct new cluster of disease-associated variants and functional analyses of mutant proteins.
Autorzy :
Sorokina EA; Department of Pediatrics and Children's Research Institute, Medical College of Wisconsin, Children's of Wisconsin, Milwaukee, WI, USA.
Reis LM; Department of Pediatrics and Children's Research Institute, Medical College of Wisconsin, Children's of Wisconsin, Milwaukee, WI, USA.
Thompson S; Department of Pediatrics and Children's Research Institute, Medical College of Wisconsin, Children's of Wisconsin, Milwaukee, WI, USA.
Agre K; Department of Clinical Genomics, Mayo Clinic, Rochester, MN, USA.
Babovic-Vuksanovic D; Department of Clinical Genomics, Mayo Clinic, Rochester, MN, USA.; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Ellingson MS; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Hasadsri L; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
van Bever Y; Department of Clinical Genetics, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Semina EV; Department of Pediatrics and Children's Research Institute, Medical College of Wisconsin, Children's of Wisconsin, Milwaukee, WI, USA. .; Departments of Ophthalmology and Visual Sciences and Cell Biology, Neurobiology and Anatomy, The Medical College of Wisconsin, Milwaukee, WI, USA. .
Pokaż więcej
Źródło :
Human genetics [Hum Genet] 2021 Dec; Vol. 140 (12), pp. 1775-1789. Date of Electronic Publication: 2021 Oct 12.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Abnormalities, Multiple/*genetics
Mutant Proteins/*genetics
Nuclear Proteins/*genetics
Abnormalities, Multiple/metabolism ; Adolescent ; Animals ; Cells, Cultured ; Child ; Child, Preschool ; Cognitive Dysfunction/genetics ; Female ; Humans ; Male ; Mutant Proteins/metabolism ; Nuclear Proteins/metabolism ; Pedigree ; Protein Binding ; Syndrome ; Two-Hybrid System Techniques ; Vesicular Transport Proteins/metabolism
Czasopismo naukowe
Tytuł :
The Fusion of CLEC12A and MIR223HG Arises from a trans -Splicing Event in Normal and Transformed Human Cells.
Autorzy :
Dhungel BP; Gene and Stem Cell Therapy Program Centenary Institute, The University of Sydney, Camperdown, NSW 2050, Australia.; Faculty of Medicine & Health, The University of Sydney, Camperdown, NSW 2006, Australia.
Monteuuis G; Department of Biochemistry and Developmental Biology, University of Helsinki, 00014 Helsinki, Finland.
Giardina C; Gene and Stem Cell Therapy Program Centenary Institute, The University of Sydney, Camperdown, NSW 2050, Australia.
Tabar MS; Gene and Stem Cell Therapy Program Centenary Institute, The University of Sydney, Camperdown, NSW 2050, Australia.
Feng Y; Gene and Stem Cell Therapy Program Centenary Institute, The University of Sydney, Camperdown, NSW 2050, Australia.
Metierre C; Gene and Stem Cell Therapy Program Centenary Institute, The University of Sydney, Camperdown, NSW 2050, Australia.
Ho S; Gene and Stem Cell Therapy Program Centenary Institute, The University of Sydney, Camperdown, NSW 2050, Australia.
Nagarajah R; Gene and Stem Cell Therapy Program Centenary Institute, The University of Sydney, Camperdown, NSW 2050, Australia.
Fontaine ARM; Centenary Imaging and Sydney Cytometry Centenary Institute, The University of Sydney, Camperdown, NSW 2050, Australia.
Shah JS; Gene and Stem Cell Therapy Program Centenary Institute, The University of Sydney, Camperdown, NSW 2050, Australia.
Gokal D; Gene and Stem Cell Therapy Program Centenary Institute, The University of Sydney, Camperdown, NSW 2050, Australia.; Faculty of Medicine & Health, The University of Sydney, Camperdown, NSW 2006, Australia.
Bailey CG; Gene and Stem Cell Therapy Program Centenary Institute, The University of Sydney, Camperdown, NSW 2050, Australia.; Faculty of Medicine & Health, The University of Sydney, Camperdown, NSW 2006, Australia.; Cancer & Gene Regulation Laboratory Centenary Institute, The University of Sydney, Camperdown, NSW 2050, Australia.
Schmitz U; Department of Molecular & Cell Biology, College of Public Health, Medical & Vet Sciences, James Cook University, Townsville, QLD 4811, Australia.
Rasko JEJ; Gene and Stem Cell Therapy Program Centenary Institute, The University of Sydney, Camperdown, NSW 2050, Australia.; Faculty of Medicine & Health, The University of Sydney, Camperdown, NSW 2006, Australia.; Cell and Molecular Therapies, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Nov 10; Vol. 22 (22). Date of Electronic Publication: 2021 Nov 10.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Fusion*
Trans-Splicing*
Lectins, C-Type/*genetics
Leukemia, Myeloid/*genetics
MicroRNAs/*genetics
Mutant Chimeric Proteins/*genetics
Receptors, Mitogen/*genetics
Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Cell Differentiation/genetics ; Cell Line ; Cytarabine/pharmacology ; Humans ; Lectins, C-Type/metabolism ; Leukemia, Myeloid/metabolism ; MicroRNAs/metabolism ; Mutant Chimeric Proteins/metabolism ; Receptors, Mitogen/metabolism ; Transcriptional Activation
Czasopismo naukowe
Tytuł :
Analysis of the Structure-Function-Dynamics Relationships of GALT Enzyme and of Its Pathogenic Mutant p.Q188R: A Molecular Dynamics Simulation Study in Different Experimental Conditions.
Autorzy :
Verdino A; Department of Chemistry and Biology 'A. Zambelli', University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano (SA), Italy.
D'Urso G; Department of Chemistry and Biology 'A. Zambelli', University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano (SA), Italy.
Tammone C; Department of Chemistry and Biology 'A. Zambelli', University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano (SA), Italy.
Scafuri B; Department of Chemistry and Biology 'A. Zambelli', University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano (SA), Italy.; Interuniversity Center, ELFID-European Laboratory for Food Induced Diseases, University of Salerno, 84084 Fisciano (SA), Italy.
Marabotti A; Department of Chemistry and Biology 'A. Zambelli', University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano (SA), Italy.; Interuniversity Center, ELFID-European Laboratory for Food Induced Diseases, University of Salerno, 84084 Fisciano (SA), Italy.
Pokaż więcej
Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Sep 30; Vol. 26 (19). Date of Electronic Publication: 2021 Sep 30.
Typ publikacji :
Journal Article
MeSH Terms :
Mutation*
Galactosemias/*pathology
Mutant Proteins/*chemistry
Mutant Proteins/*metabolism
UTP-Hexose-1-Phosphate Uridylyltransferase/*chemistry
UTP-Hexose-1-Phosphate Uridylyltransferase/*metabolism
Galactosemias/genetics ; Humans ; Models, Molecular ; Molecular Dynamics Simulation ; Mutant Proteins/genetics ; Protein Conformation ; Structure-Activity Relationship ; UTP-Hexose-1-Phosphate Uridylyltransferase/genetics
Czasopismo naukowe
Tytuł :
Improve thermostability of Bacillus sp. TS chitosanase through structure-based alignment.
Autorzy :
Zhou Z; Tianjin Sinonocy Biological Technology Co. Ltd., Tianjin, 300308, China.
Wang X; Nanfang College of Sun Yat-Sen University, Guangzhou, 510970, China. .
Pokaż więcej
Źródło :
Scientific reports [Sci Rep] 2021 Aug 04; Vol. 11 (1), pp. 15846. Date of Electronic Publication: 2021 Aug 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hot Temperature*
Mutation*
Bacillus/*enzymology
Glycoside Hydrolases/*chemistry
Mutant Proteins/*chemistry
Catalysis ; Enzyme Stability ; Glycoside Hydrolases/genetics ; Glycoside Hydrolases/metabolism ; Kinetics ; Models, Molecular ; Mutant Proteins/genetics ; Mutant Proteins/metabolism ; Protein Conformation
Czasopismo naukowe
Tytuł :
Autophagy-independent cytoprotection by optineurin from toxicity of aggregates formed by mutant huntingtin and mutant ataxin-3.
Autorzy :
Moharir SC; CSIR-Centre for Cellular and Molecular Biology, Hyderabad 500007, India.; Tata Institute for Genetics and Society, Bangalore 560065, India.
Raghawan AK; CSIR-Centre for Cellular and Molecular Biology, Hyderabad 500007, India.
Ramaswamy R; CSIR-Centre for Cellular and Molecular Biology, Hyderabad 500007, India.
Swarup G; CSIR-Centre for Cellular and Molecular Biology, Hyderabad 500007, India.
Pokaż więcej
Źródło :
Journal of biochemistry [J Biochem] 2022 May 11; Vol. 171 (5), pp. 555-565.
Typ publikacji :
Journal Article
MeSH Terms :
Cytoprotection*
Protein Aggregates*
Animals ; Ataxin-3/genetics ; Autophagy/physiology ; Fibroblasts ; Glutamine ; Mice ; Mutant Proteins
Czasopismo naukowe
Tytuł :
The DREAM complex represses growth in response to DNA damage in Arabidopsis .
Autorzy :
Lang L; Department of Developmental Biology, University of Hamburg, Institute for Plant Sciences and Microbiology, Hamburg, Germany.
Pettkó-Szandtner A; Laboratory of Proteomic Research, Biological Research Centre, Szeged, Hungary.; Institute of Plant Biology, Biological Research Centre, Szeged, Hungary.
Tunçay Elbaşı H; Department of Developmental Biology, University of Hamburg, Institute for Plant Sciences and Microbiology, Hamburg, Germany.
Takatsuka H; School of Biological Science and Technology, College of Science and Engineering, Kanazawa University, Kanazawa, Japan.
Nomoto Y; School of Biological Science and Technology, College of Science and Engineering, Kanazawa University, Kanazawa, Japan.
Zaki A; Department of Biological Sciences, Centre for Systems and Synthetic Biology, Royal Holloway University of London, Egham, UK.; School of Life Sciences, University of Warwick, Coventry, UK.
Dorokhov S; Department of Biological Sciences, Centre for Systems and Synthetic Biology, Royal Holloway University of London, Egham, UK.
De Jaeger G; Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.; Vlaams Instituut voor Biotechnologie (VIB) Center for Plant Systems Biology, Ghent, Belgium.
Eeckhout D; Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.; Vlaams Instituut voor Biotechnologie (VIB) Center for Plant Systems Biology, Ghent, Belgium.
Ito M; School of Biological Science and Technology, College of Science and Engineering, Kanazawa University, Kanazawa, Japan.
Magyar Z; Institute of Plant Biology, Biological Research Centre, Szeged, Hungary.
Bögre L; Vlaams Instituut voor Biotechnologie (VIB) Center for Plant Systems Biology, Ghent, Belgium.
Heese M; Department of Developmental Biology, University of Hamburg, Institute for Plant Sciences and Microbiology, Hamburg, Germany .
Schnittger A; Department of Developmental Biology, University of Hamburg, Institute for Plant Sciences and Microbiology, Hamburg, Germany .
Pokaż więcej
Źródło :
Life science alliance [Life Sci Alliance] 2021 Sep 28; Vol. 4 (12). Date of Electronic Publication: 2021 Sep 28 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Arabidopsis/*genetics
Arabidopsis/*growth & development
Arabidopsis Proteins/*metabolism
DNA Damage/*genetics
E2F Transcription Factors/*metabolism
Mutant Proteins/*metabolism
Signal Transduction/*genetics
Trans-Activators/*metabolism
Transcription Factors/*metabolism
Arabidopsis Proteins/genetics ; Cell Cycle Checkpoints/genetics ; DNA Repair/genetics ; E2F Transcription Factors/genetics ; Gene Expression Regulation, Plant ; Mutant Proteins/genetics ; Mutation ; Plant Roots/genetics ; Plant Roots/growth & development ; Plants, Genetically Modified ; Trans-Activators/genetics
Czasopismo naukowe
Tytuł :
NBD2 Is Required for the Rescue of Mutant F508del CFTR by a Thiazole-Based Molecule: A Class II Corrector for the Multi-Drug Therapy of Cystic Fibrosis.
Autorzy :
Brandas C; Istituto di Biofisica, Consiglio Nazionale delle Ricerche, Via De Marini 6, 16149 Genova, Italy.
Ludovico A; Istituto di Biofisica, Consiglio Nazionale delle Ricerche, Via De Marini 6, 16149 Genova, Italy.
Parodi A; Department of Experimental Medicine, Section of Biochemistry, University of Genova, Viale Benedetto XV 1, 16132 Genova, Italy.
Moran O; Istituto di Biofisica, Consiglio Nazionale delle Ricerche, Via De Marini 6, 16149 Genova, Italy.
Millo E; Department of Experimental Medicine, Section of Biochemistry, University of Genova, Viale Benedetto XV 1, 16132 Genova, Italy.
Cichero E; Department of Pharmacy, Section of Medicinal Chemistry, School of Medical and Pharmaceutical Sciences, University of Genova, Viale Benedetto XV 3, 16132 Genova, Italy.
Baroni D; Istituto di Biofisica, Consiglio Nazionale delle Ricerche, Via De Marini 6, 16149 Genova, Italy.
Pokaż więcej
Źródło :
Biomolecules [Biomolecules] 2021 Sep 28; Vol. 11 (10). Date of Electronic Publication: 2021 Sep 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cystic Fibrosis/*drug therapy
Cystic Fibrosis Transmembrane Conductance Regulator/*genetics
Mutant Proteins/*genetics
Thiazoles/*pharmacology
Cell Membrane/drug effects ; Cell Membrane/genetics ; Cystic Fibrosis/genetics ; Cystic Fibrosis/pathology ; Epithelial Cells/drug effects ; Gene Expression Regulation/drug effects ; HEK293 Cells ; Humans ; Mutant Proteins/drug effects ; Phenylalanine/genetics
Czasopismo naukowe
Tytuł :
A Sort-Seq Approach to the Development of Single Fluorescent Protein Biosensors.
Autorzy :
Koberstein JN; Vollum Institute, Oregon Health & Science University, Portland, Oregon 97239, United States.
Stewart ML; Vollum Institute, Oregon Health & Science University, Portland, Oregon 97239, United States.
Mighell TL; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon 97239, United States.
Smith CB; Vollum Institute, Oregon Health & Science University, Portland, Oregon 97239, United States.
Cohen MS; Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, Oregon 97239, United States.
Pokaż więcej
Źródło :
ACS chemical biology [ACS Chem Biol] 2021 Sep 17; Vol. 16 (9), pp. 1709-1720. Date of Electronic Publication: 2021 Aug 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Green Fluorescent Proteins/*chemistry
Mutant Proteins/*chemistry
Single Molecule Imaging/*methods
Amino Acid Sequence ; Escherichia coli/genetics ; Flow Cytometry/methods ; Gene Library ; Green Fluorescent Proteins/genetics ; High-Throughput Screening Assays ; Machine Learning ; Maltose/chemistry ; Mutant Proteins/genetics ; Protein Binding ; Protein Domains ; Pyruvic Acid/chemistry
Czasopismo naukowe
Tytuł :
Identification of Ubiquitin Variants That Inhibit the E2 Ubiquitin Conjugating Enzyme, Ube2k.
Autorzy :
Middleton AJ; Department of Biochemistry, School of Biomedical Sciences, University of Otago, Dunedin 9054, New Zealand.
Teyra J; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
Zhu J; Department of Biochemistry, School of Biomedical Sciences, University of Otago, Dunedin 9054, New Zealand.
Sidhu SS; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
Day CL; Department of Biochemistry, School of Biomedical Sciences, University of Otago, Dunedin 9054, New Zealand.
Pokaż więcej
Źródło :
ACS chemical biology [ACS Chem Biol] 2021 Sep 17; Vol. 16 (9), pp. 1745-1756. Date of Electronic Publication: 2021 Aug 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutant Proteins/*metabolism
Ubiquitin/*metabolism
Ubiquitin-Conjugating Enzymes/*antagonists & inhibitors
Catalysis ; Catalytic Domain ; Escherichia coli/genetics ; Hydrophobic and Hydrophilic Interactions ; Models, Molecular ; Mutant Proteins/genetics ; Protein Binding ; Protein Domains ; Protein Processing, Post-Translational ; Structure-Activity Relationship ; Substrate Specificity ; Ubiquitin/genetics ; Ubiquitin-Activating Enzymes/metabolism
Czasopismo naukowe
Tytuł :
McH-lpr/lpr-RA1 mice: A novel spontaneous mouse model of autoimmune sialadenitis.
Autorzy :
Saito K; Liaison Centre for Innovative Dentistry, Tohoku University Graduate School of Dentistry, Sendai, Japan.
Mori S; Department of Oral and Maxillofacial Surgery, Tohoku University Hospital, Sendai, Japan; Laboratory of Biomedical Engineering for Cancer, Department of Biomedical Engineering, Tohoku University Graduate School of Biomedical Engineering, Sendai, Japan.
Kodama T; Laboratory of Biomedical Engineering for Cancer, Department of Biomedical Engineering, Tohoku University Graduate School of Biomedical Engineering, Sendai, Japan. Electronic address: .
Pokaż więcej
Źródło :
Immunology letters [Immunol Lett] 2021 Sep; Vol. 237, pp. 3-10. Date of Electronic Publication: 2021 Jun 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Sjogren's Syndrome*/genetics
Sjogren's Syndrome*/immunology
Autoimmune Diseases/*immunology
Mice, Inbred Strains/*immunology
Mice, Mutant Strains/*immunology
Sialadenitis/*immunology
Vasculitis/*immunology
Animals ; Animals, Congenic ; Apoptosis ; Aquaporin 5/biosynthesis ; Aquaporin 5/genetics ; Autoantigens/biosynthesis ; Autoantigens/genetics ; Autoimmune Diseases/genetics ; Autoimmune Diseases/pathology ; DNA, Single-Stranded/analysis ; Female ; Genetic Predisposition to Disease ; Mice ; Mice, Inbred C3H ; Mice, Inbred Strains/genetics ; Mice, Mutant Strains/genetics ; NADPH Oxidase 2/biosynthesis ; NADPH Oxidase 2/genetics ; Ribonucleoproteins/biosynthesis ; Ribonucleoproteins/genetics ; Severity of Illness Index ; Sialadenitis/genetics ; Sialadenitis/pathology ; Submandibular Gland/metabolism ; Submandibular Gland/pathology ; Vasculitis/genetics ; Vasculitis/pathology
Czasopismo naukowe
Tytuł :
Transglutaminase 6 Is Colocalized and Interacts with Mutant Huntingtin in Huntington Disease Rodent Animal Models.
Autorzy :
Schulze-Krebs A; Experimental Therapy, Preclinical Experimental Center, University Hospital Erlangen (UKEr), Friedrich-Alexander-University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Canneva F; Experimental Therapy, Preclinical Experimental Center, University Hospital Erlangen (UKEr), Friedrich-Alexander-University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Stemick J; Department of Molecular Neurology, University Hospital Erlangen (UKEr), Friedrich-Alexander-University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Plank AC; Experimental Therapy, Preclinical Experimental Center, University Hospital Erlangen (UKEr), Friedrich-Alexander-University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Harrer J; Experimental Therapy, Preclinical Experimental Center, University Hospital Erlangen (UKEr), Friedrich-Alexander-University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Bates GP; Huntington's Disease Centre, Department of Neurodegenerative Disease and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Aeschlimann D; Matrix Biology and Tissue Repair Research Unit, College of Biomedical and Life Sciences, School of Dentistry, Cardiff University, Cardiff CF14 4XY, UK.
Steffan JS; Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA.; Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697, USA.
von Hörsten S; Experimental Therapy, Preclinical Experimental Center, University Hospital Erlangen (UKEr), Friedrich-Alexander-University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 18; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 18.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
Mutation*
Huntingtin Protein/*metabolism
Huntington Disease/*pathology
Mutant Proteins/*metabolism
Neurons/*metabolism
Transglutaminases/*metabolism
Animals ; Huntingtin Protein/genetics ; Huntington Disease/genetics ; Huntington Disease/metabolism ; Mice ; Mice, Transgenic ; Mutant Proteins/genetics ; Rats ; Transglutaminases/genetics
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies