Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Wyszukujesz frazę ""Mutant Proteins"" wg kryterium: Temat


Tytuł:
Improve thermostability of Bacillus sp. TS chitosanase through structure-based alignment.
Autorzy:
Zhou Z; Tianjin Sinonocy Biological Technology Co. Ltd., Tianjin, 300308, China.
Wang X; Nanfang College of Sun Yat-Sen University, Guangzhou, 510970, China. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2021 Aug 04; Vol. 11 (1), pp. 15846. Date of Electronic Publication: 2021 Aug 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Hot Temperature*
Mutation*
Bacillus/*enzymology
Glycoside Hydrolases/*chemistry
Mutant Proteins/*chemistry
Catalysis ; Enzyme Stability ; Glycoside Hydrolases/genetics ; Glycoside Hydrolases/metabolism ; Kinetics ; Models, Molecular ; Mutant Proteins/genetics ; Mutant Proteins/metabolism ; Protein Conformation
Czasopismo naukowe
Tytuł:
Discovery of the allosteric inhibitor from actinomyces metabolites to target EGFR mutant protein: molecular modeling and free energy approach.
Autorzy:
Saini R; School of Biochemical Engineering, Indian Institute of Technology (BHU), Varanasi, 221005, India.
Kumari S; School of Biochemical Engineering, Indian Institute of Technology (BHU), Varanasi, 221005, India.
Bhatnagar A; School of Biochemical Engineering, Indian Institute of Technology (BHU), Varanasi, 221005, India.
Singh A; Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India. .
Mishra A; School of Biochemical Engineering, Indian Institute of Technology (BHU), Varanasi, 221005, India. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2023 Jun 01; Vol. 13 (1), pp. 8885. Date of Electronic Publication: 2023 Jun 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*/genetics
Lung Neoplasms*/genetics
Humans ; ErbB Receptors/metabolism ; Molecular Docking Simulation ; Mutant Proteins/genetics ; Ligands ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/chemistry ; Mutation ; Molecular Dynamics Simulation
Czasopismo naukowe
Tytuł:
Quantifying mutant huntingtin protein in human cerebrospinal fluid to support the development of huntingtin-lowering therapies.
Autorzy:
Vauleon S; Regulated Bioanalysis, Pharmaceutical Sciences, Pharma Research and Early Development (pRED), F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Schutz K; Regulated Bioanalysis, Pharmaceutical Sciences, Pharma Research and Early Development (pRED), F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Massonnet B; Regulated Bioanalysis, Pharmaceutical Sciences, Pharma Research and Early Development (pRED), F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Gruben N; ICON Bioanalytical Laboratories, Assen, The Netherlands.
Manchester M; Pharmaceutical Sciences, Pharma Research and Early Development (pRED), F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Buehler A; Regulated Bioanalysis, Pharmaceutical Sciences, Pharma Research and Early Development (pRED), F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Schick E; Regulated Bioanalysis, Pharmaceutical Sciences, Pharma Research and Early Development (pRED), F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Boak L; F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Hawellek DJ; Biomarkers and Translational Technologies, Pharma Research and Early Development (pRED), F. Hoffmann-La Roche Ltd, Basel, Switzerland. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2023 Apr 01; Vol. 13 (1), pp. 5332. Date of Electronic Publication: 2023 Apr 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Huntington Disease*/drug therapy
Huntington Disease*/genetics
Huntington Disease*/cerebrospinal fluid
Humans ; Huntingtin Protein/genetics ; Huntingtin Protein/metabolism ; Mutant Proteins ; Recombinant Proteins/genetics ; Biomarkers
Czasopismo naukowe
Tytuł:
Impaired NEPHRIN localization in kidney organoids derived from nephrotic patient iPS cells.
Autorzy:
Ohmori T; Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto, 860-0811, Japan.
De S; Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto, 860-0811, Japan.
Tanigawa S; Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto, 860-0811, Japan.
Miike K; Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto, 860-0811, Japan.
Islam M; Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto, 860-0811, Japan.
Soga M; Department of Cell Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, 860-0811, Japan.
Era T; Department of Cell Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, 860-0811, Japan.
Shiona S; Department of Pediatrics, Oita Prefectural Hospital, Oita, 870-0855, Japan.
Nakanishi K; Department of Child Health and Welfare (Pediatrics), Graduate School of Medicine, University of the Ryukyus, Okinawa, 903-0215, Japan.; Genetic Consulting Unit, University of the Ryukyus Hospital, Okinawa, 903-0215, Japan.
Nakazato H; Department of Pediatrics, Faculty of Life Sciences, Kumamoto University, Kumamoto, 860-8556, Japan.
Nishinakamura R; Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto, 860-0811, Japan. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2021 Feb 17; Vol. 11 (1), pp. 3982. Date of Electronic Publication: 2021 Feb 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Induced Pluripotent Stem Cells/*metabolism
Membrane Proteins/*metabolism
Mutant Proteins/*metabolism
Nephrotic Syndrome/*physiopathology
Organoids/*metabolism
Amino Acid Sequence ; HEK293 Cells ; Humans ; Intracellular Signaling Peptides and Proteins/metabolism ; Kidney ; Male ; Membrane Proteins/genetics ; Mutant Proteins/genetics ; Mutation, Missense
SCR Disease Name:
Nephrosis, congenital
Czasopismo naukowe
Tytuł:
Atypical chemokine receptor ACKR2-V41A has decreased CCL2 binding, scavenging, and activation, supporting sustained inflammation and increased Alzheimer's disease risk.
Autorzy:
Murcia JDG; Brigham Young University, Department of Biology, 4102 Life Sciences Building, Provo, Utah, 84602, USA.
Weinert A; Brigham Young University, Department of Microbiology and Molecular Biology, 4007 Life Sciences Building, Provo, Utah, 84602, USA.
Freitas CMT; Brigham Young University, Department of Microbiology and Molecular Biology, 4007 Life Sciences Building, Provo, Utah, 84602, USA.; Roseman University of Health Science College of Dental Medicine 10894 S, River Front Parkway, South Jordan, UT, 84095, USA.
Arens DK; Brigham Young University, Department of Microbiology and Molecular Biology, 4007 Life Sciences Building, Provo, Utah, 84602, USA.
Ferrel MN; Brigham Young University, Department of Biology, 4102 Life Sciences Building, Provo, Utah, 84602, USA.
Grose JH; Brigham Young University, Department of Microbiology and Molecular Biology, 4007 Life Sciences Building, Provo, Utah, 84602, USA.
Ridge PG; Brigham Young University, Department of Biology, 4102 Life Sciences Building, Provo, Utah, 84602, USA.
Wilson E; Brigham Young University, Department of Microbiology and Molecular Biology, 4007 Life Sciences Building, Provo, Utah, 84602, USA.
Kauwe JSK; Brigham Young University, Department of Biology, 4102 Life Sciences Building, Provo, Utah, 84602, USA. .
Weber KS; Brigham Young University, Department of Microbiology and Molecular Biology, 4007 Life Sciences Building, Provo, Utah, 84602, USA. scott_.
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2020 May 15; Vol. 10 (1), pp. 8019. Date of Electronic Publication: 2020 May 15.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Mutant Proteins*
Alzheimer Disease/*etiology
Chemokine CCL2/*metabolism
Inflammation/*metabolism
Receptors, Chemokine/*chemistry
Receptors, Chemokine/*metabolism
Actin Depolymerizing Factors/metabolism ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amino Acid Substitution ; Animals ; CHO Cells ; Cricetulus ; Disease Susceptibility ; Humans ; Hydrophobic and Hydrophilic Interactions ; Inflammation/complications ; Inflammation/genetics ; Kinetics ; Models, Molecular ; Phosphorylation ; Protein Binding ; Protein Conformation ; Receptors, Chemokine/genetics ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł:
Identification of thiostrepton as a pharmacological approach to rescue misfolded alpha-sarcoglycan mutant proteins from degradation.
Autorzy:
Hoch L; CECS, I-Stem, 91100, Corbeil-Essonnes, France.; INSERM U861, I-Stem, 91100, Corbeil-Essonnes, France.; UEVE U861, I-Stem, 91100, Corbeil-Essonnes, France.
Henriques SF; INTEGRARE, Genethon, Inserm, Univ Evry, Université Paris-Saclay, Evry, France.
Bruge C; CECS, I-Stem, 91100, Corbeil-Essonnes, France.; INSERM U861, I-Stem, 91100, Corbeil-Essonnes, France.; UEVE U861, I-Stem, 91100, Corbeil-Essonnes, France.
Marsolier J; INTEGRARE, Genethon, Inserm, Univ Evry, Université Paris-Saclay, Evry, France.
Benabides M; CECS, I-Stem, 91100, Corbeil-Essonnes, France.; INSERM U861, I-Stem, 91100, Corbeil-Essonnes, France.; UEVE U861, I-Stem, 91100, Corbeil-Essonnes, France.
Bourg N; INTEGRARE, Genethon, Inserm, Univ Evry, Université Paris-Saclay, Evry, France.
Tournois J; CECS, I-Stem, 91100, Corbeil-Essonnes, France.; INSERM U861, I-Stem, 91100, Corbeil-Essonnes, France.; UEVE U861, I-Stem, 91100, Corbeil-Essonnes, France.
Mahé G; CECS, I-Stem, 91100, Corbeil-Essonnes, France.; INSERM U861, I-Stem, 91100, Corbeil-Essonnes, France.; UEVE U861, I-Stem, 91100, Corbeil-Essonnes, France.
Morizur L; CECS, I-Stem, 91100, Corbeil-Essonnes, France.; INSERM U861, I-Stem, 91100, Corbeil-Essonnes, France.; UEVE U861, I-Stem, 91100, Corbeil-Essonnes, France.
Jarrige M; CECS, I-Stem, 91100, Corbeil-Essonnes, France.; INSERM U861, I-Stem, 91100, Corbeil-Essonnes, France.; UEVE U861, I-Stem, 91100, Corbeil-Essonnes, France.
Bigot A; Institut de Myologie, INSERM U974, Sorbonne Université, Paris, France.
Richard I; INTEGRARE, Genethon, Inserm, Univ Evry, Université Paris-Saclay, Evry, France. .
Nissan X; CECS, I-Stem, 91100, Corbeil-Essonnes, France. .; INSERM U861, I-Stem, 91100, Corbeil-Essonnes, France. .; UEVE U861, I-Stem, 91100, Corbeil-Essonnes, France. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2019 May 06; Vol. 9 (1), pp. 6915. Date of Electronic Publication: 2019 May 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mutant Proteins/*chemistry
Mutant Proteins/*metabolism
Protein Folding/*drug effects
Proteolysis/*drug effects
Sarcoglycans/*chemistry
Sarcoglycans/*metabolism
Thiostrepton/*pharmacology
Cell Line ; Cell Membrane/drug effects ; Cell Membrane/metabolism ; Drug Evaluation, Preclinical ; Humans ; Induced Pluripotent Stem Cells/cytology ; Mutant Proteins/genetics ; Myoblasts/cytology ; Myoblasts/drug effects ; Sarcoglycans/genetics
Czasopismo naukowe
Tytuł:
The conserved C-terminal residues of FAM83H are required for the recruitment of casein kinase 1 to the keratin cytoskeleton.
Autorzy:
Kuga T; Laboratory of Analytics for Biomolecules, Faculty of Pharmaceutical Science, Setsunan University, 45-1 Nagaotoge-cho, Hirakata-shi, Osaka, 573-0101, Japan. .
Inoue N; Laboratory of Analytics for Biomolecules, Faculty of Pharmaceutical Science, Setsunan University, 45-1 Nagaotoge-cho, Hirakata-shi, Osaka, 573-0101, Japan.
Sometani K; Laboratory of Analytics for Biomolecules, Faculty of Pharmaceutical Science, Setsunan University, 45-1 Nagaotoge-cho, Hirakata-shi, Osaka, 573-0101, Japan.
Murataka S; Laboratory of Analytics for Biomolecules, Faculty of Pharmaceutical Science, Setsunan University, 45-1 Nagaotoge-cho, Hirakata-shi, Osaka, 573-0101, Japan.
Saraya M; Laboratory of Analytics for Biomolecules, Faculty of Pharmaceutical Science, Setsunan University, 45-1 Nagaotoge-cho, Hirakata-shi, Osaka, 573-0101, Japan.
Sugita R; Laboratory of Analytics for Biomolecules, Faculty of Pharmaceutical Science, Setsunan University, 45-1 Nagaotoge-cho, Hirakata-shi, Osaka, 573-0101, Japan.
Mikami T; Pax Creation Medical Lab., LLC, Iwate, 020-0805, Japan.
Takeda Y; Division of Clinical Pathology, Department of Reconstructive Oral and Maxillofacial Surgery, School of Dentistry, Iwate Medical University, Iwate, 028-3694, Japan.
Taniguchi M; Laboratory of Analytics for Biomolecules, Faculty of Pharmaceutical Science, Setsunan University, 45-1 Nagaotoge-cho, Hirakata-shi, Osaka, 573-0101, Japan.
Nishida K; Department of Integrative Pharmaceutical Sciences, Faculty of Pharmaceutical Science, Setsunan University, Osaka, 573-0101, Japan.
Yamagishi N; Laboratory of Analytics for Biomolecules, Faculty of Pharmaceutical Science, Setsunan University, 45-1 Nagaotoge-cho, Hirakata-shi, Osaka, 573-0101, Japan.
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2022 Jul 12; Vol. 12 (1), pp. 11819. Date of Electronic Publication: 2022 Jul 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Casein Kinase I*/genetics
Casein Kinase I*/metabolism
Keratins*/genetics
Keratins*/metabolism
Amino Acids/metabolism ; Animals ; Casein Kinases/metabolism ; Cytoskeleton/metabolism ; Microtubules/metabolism ; Mutant Proteins/metabolism
Czasopismo naukowe
Tytuł:
Molecular modelling evaluation of exon 18 His845_Asn848delinsPro PDGFRα mutation in a metastatic GIST patient responding to imatinib.
Autorzy:
Nannini M; Department of Specialized, Experimental and Diagnostic Medicine, Sant'Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 9, 40138, Bologna, Italy.
Tarantino G; 'Giorgio Prodi' Cancer Research Centre, University of Bologna, Bologna, Italy.
Indio V; 'Giorgio Prodi' Cancer Research Centre, University of Bologna, Bologna, Italy. .
Ravegnini G; Department of Pharmacy and Biotechnology, Via Irnerio 48, 40126, Bologna, Italy.
Astolfi A; 'Giorgio Prodi' Cancer Research Centre, University of Bologna, Bologna, Italy.
Urbini M; Department of Specialized, Experimental and Diagnostic Medicine, Sant'Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 9, 40138, Bologna, Italy.
De Leo A; Pathology Unit, S.Orsola-Malpighi Hospital, Via Massarenti 9, 40138, Bologna, Italy.
Santini D; Pathology Unit, S.Orsola-Malpighi Hospital, Via Massarenti 9, 40138, Bologna, Italy.
Ceccarelli C; Pathology Unit, S.Orsola-Malpighi Hospital, Via Massarenti 9, 40138, Bologna, Italy.
Gruppioni E; Laboratory of Oncologic Molecular Pathology, S.Orsola-Malpighi Hospital, Via Massarenti 9, 40138, Bologna, Italy.
Altimari A; Laboratory of Oncologic Molecular Pathology, S.Orsola-Malpighi Hospital, Via Massarenti 9, 40138, Bologna, Italy.
Castellucci P; Nuclear Medicine Unit, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.
Fanti S; Nuclear Medicine Unit, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.
Di Scioscio V; Department of Radiology, S. Orsola Malpighi Hospital, University of Bologna, Bologna, Italy.
Saponara M; Department of Specialized, Experimental and Diagnostic Medicine, Sant'Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 9, 40138, Bologna, Italy.
Gatto L; Department of Specialized, Experimental and Diagnostic Medicine, Sant'Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 9, 40138, Bologna, Italy.
Pession A; 'Giorgio Prodi' Cancer Research Centre, University of Bologna, Bologna, Italy.
Martelli PL; Biocomputing Group, Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
Casadio R; Biocomputing Group, Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
Pantaleo MA; Department of Specialized, Experimental and Diagnostic Medicine, Sant'Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 9, 40138, Bologna, Italy.; 'Giorgio Prodi' Cancer Research Centre, University of Bologna, Bologna, Italy.
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2019 Feb 18; Vol. 9 (1), pp. 2172. Date of Electronic Publication: 2019 Feb 18.
Typ publikacji:
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
INDEL Mutation*
Gastrointestinal Neoplasms/*enzymology
Gastrointestinal Neoplasms/*genetics
Gastrointestinal Stromal Tumors/*enzymology
Gastrointestinal Stromal Tumors/*genetics
Mutant Proteins/*chemistry
Mutant Proteins/*genetics
Receptor, Platelet-Derived Growth Factor alpha/*chemistry
Receptor, Platelet-Derived Growth Factor alpha/*genetics
Aged ; Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/therapeutic use ; Binding Sites ; Computer Simulation ; Exons ; Female ; Gastrointestinal Neoplasms/drug therapy ; Gastrointestinal Stromal Tumors/drug therapy ; Humans ; Imatinib Mesylate/pharmacokinetics ; Imatinib Mesylate/therapeutic use ; Models, Molecular ; Molecular Docking Simulation ; Mutant Proteins/metabolism ; Protein Conformation ; Receptor, Platelet-Derived Growth Factor alpha/metabolism
Czasopismo naukowe
Tytuł:
Identification of Thermus aquaticus DNA polymerase variants with increased mismatch discrimination and reverse transcriptase activity from a smart enzyme mutant library.
Autorzy:
Raghunathan G; Department of Chemistry, University of Konstanz, Universitätsstraße 10, D-78457, Konstanz, Germany.
Marx A; Department of Chemistry, University of Konstanz, Universitätsstraße 10, D-78457, Konstanz, Germany. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2019 Jan 24; Vol. 9 (1), pp. 590. Date of Electronic Publication: 2019 Jan 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA-Directed DNA Polymerase/*metabolism
Mutant Proteins/*metabolism
RNA-Directed DNA Polymerase/*metabolism
Thermus/*enzymology
DNA-Directed DNA Polymerase/genetics ; DNA-Directed DNA Polymerase/isolation & purification ; Enzyme Stability ; Genetic Testing ; Kinetics ; Mutant Proteins/genetics ; Mutant Proteins/isolation & purification ; RNA-Directed DNA Polymerase/genetics ; RNA-Directed DNA Polymerase/isolation & purification ; Substrate Specificity
SCR Organism:
Thermus aquaticus
Czasopismo naukowe
Tytuł:
Suppression of Hepatic Bile Acid Synthesis by a non-tumorigenic FGF19 analogue Protects Mice from Fibrosis and Hepatocarcinogenesis.
Autorzy:
Gadaleta RM; Department of Interdisciplinary Medicine, 'Aldo Moro' University of Bari, Bari, Italy.; INBB, National Institute for Biostructures and Biosystems, Rome, Italy.
Scialpi N; Department of Interdisciplinary Medicine, 'Aldo Moro' University of Bari, Bari, Italy.; INBB, National Institute for Biostructures and Biosystems, Rome, Italy.
Peres C; Department of Interdisciplinary Medicine, 'Aldo Moro' University of Bari, Bari, Italy.; INBB, National Institute for Biostructures and Biosystems, Rome, Italy.
Cariello M; Department of Interdisciplinary Medicine, 'Aldo Moro' University of Bari, Bari, Italy.
Ko B; NGM Biopharmaceuticals, South San Francisco, CA, USA.
Luo J; NGM Biopharmaceuticals, South San Francisco, CA, USA.
Porru E; Department of Chemistry 'Giacomo Ciamician', Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Roda A; Department of Chemistry 'Giacomo Ciamician', Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Sabbà C; Department of Interdisciplinary Medicine, 'Aldo Moro' University of Bari, Bari, Italy.
Moschetta A; Department of Interdisciplinary Medicine, 'Aldo Moro' University of Bari, Bari, Italy. .; National Cancer Center, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2018 Nov 21; Vol. 8 (1), pp. 17210. Date of Electronic Publication: 2018 Nov 21.
Typ publikacji:
Journal Article
MeSH Terms:
Bile Acids and Salts/*biosynthesis
Biological Products/*administration & dosage
Carcinoma, Hepatocellular/*prevention & control
Fibroblast Growth Factors/*metabolism
Liver Cirrhosis/*prevention & control
Mutant Proteins/*metabolism
Animals ; Bile Acids and Salts/antagonists & inhibitors ; Disease Models, Animal ; Fibroblast Growth Factors/administration & dosage ; Fibroblast Growth Factors/genetics ; Gastrointestinal Agents/administration & dosage ; Liver Cirrhosis/complications ; Mice ; Mice, Knockout ; Mutant Proteins/administration & dosage ; Mutant Proteins/genetics ; Treatment Outcome
Czasopismo naukowe
Tytuł:
Structural basis for dimerization of the death effector domain of the F122A mutant of Caspase-8.
Autorzy:
Shen C; State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China.
Pei J; State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China.
Guo X; State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China.
Zhou L; School of Pharmacy, Fudan University, Shanghai, 201203, China.
Li Q; State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China.
Quan J; State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2018 Nov 13; Vol. 8 (1), pp. 16723. Date of Electronic Publication: 2018 Nov 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Death Effector Domain*
Point Mutation*
Protein Multimerization*
Caspase 8/*chemistry
Caspase 8/*genetics
Mutant Proteins/*chemistry
Mutant Proteins/*genetics
Caspase 8/metabolism ; Crystallography, X-Ray ; Enzyme Stability ; HeLa Cells ; Humans ; Jurkat Cells ; Models, Molecular ; Mutant Proteins/metabolism ; Protein Structure, Quaternary ; Solubility ; fas Receptor/metabolism
Czasopismo naukowe
Tytuł:
Topological data analysis gives two folding paths in HP35(nle-nle), double mutant of villin headpiece subdomain.
Autorzy:
Ichinomiya T; Department of Systems Biology, Gifu University School of Medicine, Yanagido 1-1, Gifu, 501-1194, Japan. .; The United Graduate School of Drug Discovery and Medical Information Sciences of Gifu University, Yanagido 1-1, Gifu, 501-1194, Japan. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2022 Feb 17; Vol. 12 (1), pp. 2719. Date of Electronic Publication: 2022 Feb 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Data Analysis*
Protein Folding*
Microfilament Proteins/*chemistry
Microfilament Proteins/*genetics
Mutant Proteins/*chemistry
Mutant Proteins/*genetics
Molecular Dynamics Simulation ; Protein Domains ; Protein Structure, Tertiary
Czasopismo naukowe
Tytuł:
Rational design of a helical peptide inhibitor targeting c-Myb-KIX interaction.
Autorzy:
Suetaka S; Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro, Tokyo, 153-8902, Japan.
Oka Y; Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro, Tokyo, 153-8902, Japan.
Kunihara T; Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro, Tokyo, 153-8902, Japan.
Hayashi Y; Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro, Tokyo, 153-8902, Japan.
Arai M; Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro, Tokyo, 153-8902, Japan. .; Department of Physics, Graduate School of Science, The University of Tokyo, 3-8-1 Komaba, Meguro, Tokyo, 153-8902, Japan. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2022 Jan 20; Vol. 12 (1), pp. 816. Date of Electronic Publication: 2022 Jan 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Design*
CREB-Binding Protein/*metabolism
Peptides/*metabolism
Proto-Oncogene Proteins c-myb/*metabolism
Binding Sites ; CREB-Binding Protein/chemistry ; Models, Molecular ; Mutant Proteins/chemistry ; Mutant Proteins/metabolism ; Peptides/chemistry ; Peptides/pharmacology ; Protein Binding ; Protein Conformation ; Protein Domains ; Protein Structure, Secondary ; Proto-Oncogene Proteins c-myb/genetics
Czasopismo naukowe
Tytuł:
The K-Ras(G12D)-inhibitory peptide KS-58 suppresses growth of murine CT26 colorectal cancer cell-derived tumors.
Autorzy:
Sakamoto K; Research & Development Department, Ichimaru Pharcos Company Limited, 318-1 Asagi, Motosu, Gifu, 501-0475, Japan. .
Lin B; Center for Supporting Drug Discovery and Life Science Research, Graduate School of Pharmaceutical Science, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Nunomura K; Center for Supporting Drug Discovery and Life Science Research, Graduate School of Pharmaceutical Science, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Izawa T; Laboratory of Veterinary Pathology, Osaka Prefecture University, 1-58 Rinku-Orai-Kita, Izumisano, Osaka, 598-8531, Japan.
Nakagawa S; Center for Supporting Drug Discovery and Life Science Research, Graduate School of Pharmaceutical Science, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan.; Laboratory of Biopharmaceutics, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2022 May 17; Vol. 12 (1), pp. 8121. Date of Electronic Publication: 2022 May 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Colorectal Neoplasms*/drug therapy
Colorectal Neoplasms*/genetics
Peptides*/therapeutic use
Proto-Oncogene Proteins p21(ras)*/genetics
Animals ; Mice ; Cell Line, Tumor ; Cell Proliferation ; Mutant Proteins/genetics ; Mutation
Czasopismo naukowe
Tytuł:
p.(Asp47Asn) and p.(Thr62Met): non deleterious LDL receptor missense variants functionally characterized in vitro.
Autorzy:
Benito-Vicente A; Instituto Biofisika (UPV/EHU, CSIC) and Departamento de Bioquímica, Universidad del País Vasco, Apdo. 644, 48080, Bilbao, Spain.
Siddiqi H; Instituto Biofisika (UPV/EHU, CSIC) and Departamento de Bioquímica, Universidad del País Vasco, Apdo. 644, 48080, Bilbao, Spain.
Uribe KB; Instituto Biofisika (UPV/EHU, CSIC) and Departamento de Bioquímica, Universidad del País Vasco, Apdo. 644, 48080, Bilbao, Spain.
Jebari S; Instituto Biofisika (UPV/EHU, CSIC) and Departamento de Bioquímica, Universidad del País Vasco, Apdo. 644, 48080, Bilbao, Spain.
Galicia-Garcia U; Instituto Biofisika (UPV/EHU, CSIC) and Departamento de Bioquímica, Universidad del País Vasco, Apdo. 644, 48080, Bilbao, Spain.
Larrea-Sebal A; Instituto Biofisika (UPV/EHU, CSIC) and Departamento de Bioquímica, Universidad del País Vasco, Apdo. 644, 48080, Bilbao, Spain.
Stef M; Progenika Biopharma, a Grifols Company, Derio, Spain.
Ostolaza H; Instituto Biofisika (UPV/EHU, CSIC) and Departamento de Bioquímica, Universidad del País Vasco, Apdo. 644, 48080, Bilbao, Spain.
Palacios L; Progenika Biopharma, a Grifols Company, Derio, Spain.
Martin C; Instituto Biofisika (UPV/EHU, CSIC) and Departamento de Bioquímica, Universidad del País Vasco, Apdo. 644, 48080, Bilbao, Spain. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2018 Nov 09; Vol. 8 (1), pp. 16614. Date of Electronic Publication: 2018 Nov 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mutation, Missense*
Hyperlipoproteinemia Type II/*pathology
Lipoproteins/*metabolism
Mutant Proteins/*metabolism
Receptors, LDL/*genetics
Receptors, LDL/*metabolism
Algorithms ; Animals ; CHO Cells ; Cricetinae ; Cricetulus ; Humans ; Hyperlipoproteinemia Type II/genetics ; Hyperlipoproteinemia Type II/metabolism ; In Vitro Techniques ; Mutant Proteins/genetics
Czasopismo naukowe
Tytuł:
Understanding Colour Tuning Rules and Predicting Absorption Wavelengths of Microbial Rhodopsins by Data-Driven Machine-Learning Approach.
Autorzy:
Karasuyama M; Department of Computer Science, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya, Aichi, 466-8555, Japan.; PRESTO, Japan Science and Technological Agency (JST), 4-1-8 Honcho, Kawaguchi, Saitama, 332-0012, Japan.; Center for Materials research by Information Integration, National Institute for Materials Science (NIMS), Tsukuba, 305-0047, Japan.
Inoue K; PRESTO, Japan Science and Technological Agency (JST), 4-1-8 Honcho, Kawaguchi, Saitama, 332-0012, Japan.; Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya, Aichi, 466-8555, Japan.; OptoBioTechnology Research Center, Gokiso, Showa-ku, Nagoya, Aichi, 466-8555, Japan.; The Institute for Solid State Physics, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba, 277-8581, Japan.
Nakamura R; RIKEN Center for Advanced Intelligence Project, Nihonbashi 1-chome, 1-4-1 Nihonbashi, Chuo-ku, Tokyo, 103-0027, Japan.
Kandori H; Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya, Aichi, 466-8555, Japan. .; OptoBioTechnology Research Center, Gokiso, Showa-ku, Nagoya, Aichi, 466-8555, Japan. .
Takeuchi I; Department of Computer Science, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya, Aichi, 466-8555, Japan. .; Center for Materials research by Information Integration, National Institute for Materials Science (NIMS), Tsukuba, 305-0047, Japan. .; RIKEN Center for Advanced Intelligence Project, Nihonbashi 1-chome, 1-4-1 Nihonbashi, Chuo-ku, Tokyo, 103-0027, Japan. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2018 Oct 22; Vol. 8 (1), pp. 15580. Date of Electronic Publication: 2018 Oct 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chemical Phenomena*
Color*
Mutant Proteins/*chemistry
Rhodopsins, Microbial/*chemistry
Machine Learning ; Models, Statistical ; Mutant Proteins/genetics ; Rhodopsins, Microbial/genetics
Czasopismo naukowe
Tytuł:
Tryptophan 32-mediated SOD1 aggregation is attenuated by pyrimidine-like compounds in living cells.
Autorzy:
Pokrishevsky E; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, V6T 2B5, Canada.
McAlary L; Faculty of Science Medicine and Health, University of Wollongong, Wollongong, NSW, 2522, Australia.; Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, 2522, Australia.
Farrawell NE; Faculty of Science Medicine and Health, University of Wollongong, Wollongong, NSW, 2522, Australia.; Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, 2522, Australia.
Zhao B; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, V6T 2B5, Canada.
Sher M; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, V6T 2B5, Canada.
Yerbury JJ; Faculty of Science Medicine and Health, University of Wollongong, Wollongong, NSW, 2522, Australia. .; Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, 2522, Australia. .
Cashman NR; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, V6T 2B5, Canada. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2018 Oct 22; Vol. 8 (1), pp. 15590. Date of Electronic Publication: 2018 Oct 22.
Typ publikacji:
Journal Article
MeSH Terms:
Protein Aggregation, Pathological*
Mutant Proteins/*metabolism
Pyrimidines/*metabolism
Superoxide Dismutase-1/*metabolism
Tryptophan/*metabolism
Amino Acid Substitution ; Flow Cytometry ; HEK293 Cells ; Humans ; Mass Spectrometry ; Mutant Proteins/chemistry ; Protein Stability ; Superoxide Dismutase-1/chemistry ; Superoxide Dismutase-1/genetics
Czasopismo naukowe
Tytuł:
The role of lysine palmitoylation/myristoylation in the function of the TEAD transcription factors.
Autorzy:
Mesrouze Y; Disease Area Oncology, Novartis Institutes for Biomedical Research, Novartis, 4002, Basel, Switzerland.
Aguilar G; Biozentrum, University of Basel, Spitalstrasse 41, 4056, Basel, Switzerland.
Meyerhofer M; Disease Area Oncology, Novartis Institutes for Biomedical Research, Novartis, 4002, Basel, Switzerland.
Bokhovchuk F; Disease Area Oncology, Novartis Institutes for Biomedical Research, Novartis, 4002, Basel, Switzerland.
Zimmermann C; Disease Area Oncology, Novartis Institutes for Biomedical Research, Novartis, 4002, Basel, Switzerland.
Fontana P; Disease Area Oncology, Novartis Institutes for Biomedical Research, Novartis, 4002, Basel, Switzerland.
Vissières A; Analytical Sciences and Imaging, Novartis Institutes for Biomedical Research, Novartis, WSJ 386 4.02.01, 4002, Basel, Switzerland.
Voshol H; Analytical Sciences and Imaging, Novartis Institutes for Biomedical Research, Novartis, WSJ 386 4.02.01, 4002, Basel, Switzerland.
Erdmann D; Disease Area Oncology, Novartis Institutes for Biomedical Research, Novartis, 4002, Basel, Switzerland.
Affolter M; Biozentrum, University of Basel, Spitalstrasse 41, 4056, Basel, Switzerland.
Chène P; Disease Area Oncology, Novartis Institutes for Biomedical Research, Novartis, 4002, Basel, Switzerland. patrick_.
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2022 Mar 23; Vol. 12 (1), pp. 4984. Date of Electronic Publication: 2022 Mar 23.
Typ publikacji:
Journal Article
MeSH Terms:
Drosophila Proteins*/genetics
Drosophila Proteins*/metabolism
TEA Domain Transcription Factors*
Animals ; Cysteine/metabolism ; Drosophila/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Lipoylation ; Lysine/metabolism ; Mutant Proteins/metabolism ; Protein Serine-Threonine Kinases/genetics ; Signal Transduction/genetics ; Trans-Activators/metabolism
Czasopismo naukowe
Tytuł:
Pathogenic nsSNPs that increase the risks of cancers among the Orang Asli and Malays.
Autorzy:
Khoruddin NA; Integrative Pharmacogenomics Institute (iPROMISE), Universiti Teknologi MARA (UiTM), Selangor Branch, Puncak Alam Campus, 42300, Puncak Alam, Selangor, Malaysia.; Faculty of Applied Sciences, Universiti Teknologi MARA (UiTM), Shah Alam Campus, Selangor, Malaysia.
Noorizhab MN; Integrative Pharmacogenomics Institute (iPROMISE), Universiti Teknologi MARA (UiTM), Selangor Branch, Puncak Alam Campus, 42300, Puncak Alam, Selangor, Malaysia.; Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Selangor Branch, Puncak Alam Campus, 42300, Puncak Alam, Selangor, Malaysia.
Teh LK; Integrative Pharmacogenomics Institute (iPROMISE), Universiti Teknologi MARA (UiTM), Selangor Branch, Puncak Alam Campus, 42300, Puncak Alam, Selangor, Malaysia.; Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Selangor Branch, Puncak Alam Campus, 42300, Puncak Alam, Selangor, Malaysia.
Mohd Yusof FZ; Integrative Pharmacogenomics Institute (iPROMISE), Universiti Teknologi MARA (UiTM), Selangor Branch, Puncak Alam Campus, 42300, Puncak Alam, Selangor, Malaysia.; Faculty of Applied Sciences, Universiti Teknologi MARA (UiTM), Shah Alam Campus, Selangor, Malaysia.
Salleh MZ; Integrative Pharmacogenomics Institute (iPROMISE), Universiti Teknologi MARA (UiTM), Selangor Branch, Puncak Alam Campus, 42300, Puncak Alam, Selangor, Malaysia. .; Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Selangor Branch, Puncak Alam Campus, 42300, Puncak Alam, Selangor, Malaysia. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2021 Aug 09; Vol. 11 (1), pp. 16158. Date of Electronic Publication: 2021 Aug 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Polymorphism, Single Nucleotide*
Ethnicity/*genetics
Neoplasms/*genetics
Computational Biology ; Computer Simulation ; Conserved Sequence ; Databases, Genetic/statistics & numerical data ; Female ; Genetic Predisposition to Disease ; Genome-Wide Association Study/statistics & numerical data ; Guanine Nucleotide Exchange Factors/chemistry ; Guanine Nucleotide Exchange Factors/genetics ; Humans ; Malaysia ; Male ; Models, Molecular ; Molecular Docking Simulation ; Monophenol Monooxygenase/chemistry ; Monophenol Monooxygenase/genetics ; Mutant Proteins/chemistry ; Mutant Proteins/genetics ; Mutation ; Protein Interaction Domains and Motifs ; Protein Stability ; Structural Homology, Protein ; Exome Sequencing/statistics & numerical data
Czasopismo naukowe
Tytuł:
Characterization of Split Fluorescent Protein Variants and Quantitative Analyses of Their Self-Assembly Process.
Autorzy:
Köker T; Department of Biological Sciences, University of Southern California, 1050 Child Way, Los Angeles, 90089, California, USA.
Fernandez A; Department of Biological Sciences, University of Southern California, 1050 Child Way, Los Angeles, 90089, California, USA.
Pinaud F; Department of Biological Sciences, University of Southern California, 1050 Child Way, Los Angeles, 90089, California, USA. .; Department of Chemistry, University of Southern California, 1050 Child Way, Los Angeles, 90089, California, USA. .; Department of Physics and Astronomy, University of Southern California, 1050 Child Way, Los Angeles, 90089, California, USA. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2018 Mar 28; Vol. 8 (1), pp. 5344. Date of Electronic Publication: 2018 Mar 28.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Mutant Proteins*
Protein Multimerization*
Luminescent Proteins/*chemistry
Luminescent Proteins/*metabolism
Fluorescence ; Gene Expression ; Green Fluorescent Proteins/chemistry ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Kinetics ; Luminescent Proteins/genetics ; Microscopy, Fluorescence ; Protein Binding ; Protein Folding ; Recombinant Proteins ; Spectrometry, Fluorescence
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies