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Wyszukujesz frazę ""Mutation Rate"" wg kryterium: Temat


Tytuł :
Enhanced Mutation Rate, Relaxed Selection, and the "Domino Effect" are associated with Gene Loss in Blattabacterium, A Cockroach Endosymbiont.
Autorzy :
Kinjo Y; Okinawa Institute of Science & Technology Graduate University, Tancha, Onna-son, Okinawa, Japan.
Lo N; School of Life and Environmental Sciences, University of Sydney, Sydney, NSW, Australia.
Martín PV; Okinawa Institute of Science & Technology Graduate University, Tancha, Onna-son, Okinawa, Japan.
Tokuda G; Tropical Biosphere Research Center, University of the Ryukyus, Nishihara, Okinawa, Japan.
Pigolotti S; Okinawa Institute of Science & Technology Graduate University, Tancha, Onna-son, Okinawa, Japan.
Bourguignon T; Okinawa Institute of Science & Technology Graduate University, Tancha, Onna-son, Okinawa, Japan.
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Źródło :
Molecular biology and evolution [Mol Biol Evol] 2021 Aug 23; Vol. 38 (9), pp. 3820-3831.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genome, Bacterial*
Mutation Rate*
Bacteroidetes/*genetics
Cockroaches/*microbiology
Symbiosis/*genetics
Animals ; Selection, Genetic
Czasopismo naukowe
Tytuł :
Frequency and types of EGFR mutations in Moroccan patients with non-small cell lung cancer.
Autorzy :
Lemine Sow M; Department of Medical Oncology, National Institute of Oncology, Faculty of Medicine and Pharmacy, Mohamed V University, Rabat, Morocco.
El Yacoubi H; Faculty of Medicine and Pharmacy, Mohamed V University, Rabat, Morocco.
Moukafih B; Department of Medical Oncology, National Institute of Oncology, Faculty of Medicine and Pharmacy, Mohamed V University, Rabat, Morocco.
Balde S; Department of Medical Oncology, National Institute of Oncology, Faculty of Medicine and Pharmacy, Mohamed V University, Rabat, Morocco.
Akimana G; Department of Medical Oncology, National Institute of Oncology, Faculty of Medicine and Pharmacy, Mohamed V University, Rabat, Morocco.
Najem S; Department of Medical Oncology, National Institute of Oncology, Faculty of Medicine and Pharmacy, Mohamed V University, Rabat, Morocco.
El Khoyaali S; Department of Medical Oncology, National Institute of Oncology, Faculty of Medicine and Pharmacy, Mohamed V University, Rabat, Morocco.
Abahssain H; Department of Medical Oncology, National Institute of Oncology, Faculty of Medicine and Pharmacy, Mohamed V University, Rabat, Morocco.
Chaibi A; Faculty of Medicine and Pharmacy, Mohamed V University, Rabat, Morocco.
Zeb Khan S; Department of Clinical Oncology, BINOR Cancer Hospital, Bannu, Pakistan.
Trapani D; Department of Oncology and Hematology, University of Milan.; Division of New Drug Development, European Institute of Oncology, Milan, Italy.
Benzekri A; Department of Medical Oncology, National Institute of Oncology, Faculty of Medicine and Pharmacy, Mohamed V University, Rabat, Morocco.
Ghaouti M; Department of Medical Oncology, National Institute of Oncology, Faculty of Medicine and Pharmacy, Mohamed V University, Rabat, Morocco.
Gamra L; Department of Medical Oncology, National Institute of Oncology, Faculty of Medicine and Pharmacy, Mohamed V University, Rabat, Morocco.
Mestari A; Department of Medical Oncology, National Institute of Oncology, Faculty of Medicine and Pharmacy, Mohamed V University, Rabat, Morocco.
Kettani F; Department of Medical Oncology, National Institute of Oncology, Faculty of Medicine and Pharmacy, Mohamed V University, Rabat, Morocco.
Rahali Y; Faculty of Medicine and Pharmacy, Mohamed V University, Rabat, Morocco.
Mrabti H; Department of Medical Oncology, National Institute of Oncology, Faculty of Medicine and Pharmacy, Mohamed V University, Rabat, Morocco.
Elghissassi I; Department of Medical Oncology, National Institute of Oncology, Faculty of Medicine and Pharmacy, Mohamed V University, Rabat, Morocco.
Errihani H; Department of Medical Oncology, National Institute of Oncology, Faculty of Medicine and Pharmacy, Mohamed V University, Rabat, Morocco.
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Źródło :
Tumori [Tumori] 2021 Aug; Vol. 107 (4), pp. 335-340. Date of Electronic Publication: 2020 Oct 20.
Typ publikacji :
Journal Article
MeSH Terms :
Mutation Rate*
Adenocarcinoma of Lung/*epidemiology
Biomarkers, Tumor/*genetics
Carcinoma, Non-Small-Cell Lung/*epidemiology
Lung Neoplasms/*epidemiology
Adenocarcinoma of Lung/genetics ; Adenocarcinoma of Lung/pathology ; Adult ; Aged ; Aged, 80 and over ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; ErbB Receptors/genetics ; Female ; Follow-Up Studies ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Male ; Middle Aged ; Morocco/epidemiology ; Prognosis ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Base-substitution mutation rate across the nuclear genome of Alpheus snapping shrimp and the timing of isolation by the Isthmus of Panama.
Autorzy :
Silliman K; School of Fisheries, Aquaculture, and Aquatic Sciences, Auburn University, Auburn, AL, 36849, USA. .; Committee on Evolutionary Biology, University of Chicago, Chicago, IL, 60637, USA. .
Indorf JL; Department of Biology, University of Miami, Coral Gables, FL, 33146, USA.
Knowlton N; National Museum of Natural History, Smithsonian Institution, Washington, DC, USA.
Browne WE; Department of Biology, University of Miami, Coral Gables, FL, 33146, USA.
Hurt C; Department of Biology, University of Miami, Coral Gables, FL, 33146, USA.; Department of Biology, Tennessee Tech University, Cookeville, TN, 38505, USA.
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Źródło :
BMC ecology and evolution [BMC Ecol Evol] 2021 May 28; Vol. 21 (1), pp. 104. Date of Electronic Publication: 2021 May 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Decapoda*/genetics
Mutation Rate*
Animals ; Bayes Theorem ; Panama ; Phylogeny
Czasopismo naukowe
Tytuł :
Analysis of EGFR, KRAS, and PIK3CA gene mutation rates and clinical distribution in patients with different types of lung cancer.
Autorzy :
Li S; Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China.
Li X; Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China. .
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Źródło :
World journal of surgical oncology [World J Surg Oncol] 2021 Jul 03; Vol. 19 (1), pp. 197. Date of Electronic Publication: 2021 Jul 03.
Typ publikacji :
Journal Article
MeSH Terms :
Lung Neoplasms*
Mutation Rate*
Class I Phosphatidylinositol 3-Kinases ; ErbB Receptors/genetics ; Female ; Hospital Distribution Systems ; Humans ; Male ; Mutation ; Prognosis ; Proto-Oncogene Proteins p21(ras)
Czasopismo naukowe
Tytuł :
Unexpectedly high mutation rate of a deep-sea hyperthermophilic anaerobic archaeon.
Autorzy :
Gu J; State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, 200240, China.; State Key Laboratory of Ocean Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
Wang X; Simon F. S. Li Marine Science Laboratory, School of Life Sciences and State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
Ma X; State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, 200240, China.; State Key Laboratory of Ocean Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
Sun Y; Simon F. S. Li Marine Science Laboratory, School of Life Sciences and State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
Xiao X; State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, 200240, China. .; State Key Laboratory of Ocean Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China. .
Luo H; Simon F. S. Li Marine Science Laboratory, School of Life Sciences and State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China. .; Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, 518000, China. .; Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Hong Kong SAR, China. .
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Źródło :
The ISME journal [ISME J] 2021 Jun; Vol. 15 (6), pp. 1862-1869. Date of Electronic Publication: 2021 Jan 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation Rate*
Thermococcus*/genetics
Anaerobiosis ; Base Sequence ; Phylogeny ; Seawater
Czasopismo naukowe
Tytuł :
A nearly-neutral biallelic Moran model with biased mutation and linear and quadratic selection.
Autorzy :
Vogl C; Department of Biomedical Sciences, Vetmeduni Vienna, Veterinärplatz 1, A-1210 Wien, Austria; Vienna Graduate School of Population Genetics, A-1210 Wien, Austria. Electronic address: .
Mikula LC; Centre for Biological Diversity, School of Biology, University of St. Andrews, St Andrews KY16 9TH, UK. Electronic address: .
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Źródło :
Theoretical population biology [Theor Popul Biol] 2021 Jun; Vol. 139, pp. 1-17. Date of Electronic Publication: 2021 May 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drosophila melanogaster*/genetics
Mutation Rate*
Animals ; Drosophila simulans ; Evolution, Molecular ; Models, Genetic ; Mutation ; Polymorphism, Genetic ; Selection, Genetic
Czasopismo naukowe
Tytuł :
The role of E255K/V-inclusive mutations in a Philadelphia-positive acute lymphoblastic leukemia with mutation evolution during sequential TKIs therapies: A case report.
Autorzy :
Zhao M; Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan.
Gui X; Department of Hematology, People's Hospital of Hanchuan, Wuhan University, Hanchuan, Hubei, China.
Wu Q; Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan.
Xia L; Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan.
Wang Y; Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan.
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Źródło :
Medicine [Medicine (Baltimore)] 2021 May 07; Vol. 100 (18), pp. e25579.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Mutation Rate*
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Drug Resistance, Neoplasm/*genetics
Neoplasm Recurrence, Local/*genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*drug therapy
Protein Kinase Inhibitors/*pharmacology
Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; DNA Mutational Analysis ; Fatal Outcome ; Female ; Fusion Proteins, bcr-abl/genetics ; Humans ; Imidazoles/pharmacology ; Imidazoles/therapeutic use ; Karyotyping ; Philadelphia Chromosome ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Protein Kinase Inhibitors/therapeutic use ; Pyridazines/pharmacology ; Pyridazines/therapeutic use
Czasopismo naukowe
Tytuł :
Mutation Rates and Selection on Synonymous Mutations in SARS-CoV-2.
Autorzy :
De Maio N; European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridgeshire, United Kingdom.
Walker CR; European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridgeshire, United Kingdom.; Department of Genetics, University of Cambridge, United Kingdom.
Turakhia Y; Department of Biomolecular Engineering, University of California, Santa Cruz, California, USA.; Genomics Institute, University of California, Santa Cruz, California, USA.
Lanfear R; Department of Ecology and Evolution, Research School of Biology, Australian National University, Canberra, ACT, Australia.
Corbett-Detig R; Department of Biomolecular Engineering, University of California, Santa Cruz, California, USA.; Genomics Institute, University of California, Santa Cruz, California, USA.
Goldman N; European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridgeshire, United Kingdom.
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Źródło :
Genome biology and evolution [Genome Biol Evol] 2021 May 07; Vol. 13 (5).
Typ publikacji :
Journal Article
MeSH Terms :
Mutation Rate*
Selection, Genetic*
SARS-CoV-2/*genetics
Silent Mutation/*genetics
COVID-19/virology ; Evolution, Molecular ; Genome, Viral ; Phylogeny ; RNA, Viral/genetics ; SARS-CoV-2/classification ; Sequence Analysis, RNA
Czasopismo naukowe
Tytuł :
Temporal Dynamics and Evolution of SARS-CoV-2 Demonstrate the Necessity of Ongoing Viral Genome Sequencing in Ontario, Canada.
Autorzy :
Sjaarda CP; Department of Psychiatry, Queen's University, Kingston, Ontario, Canada .; Queen's Genomics Lab at Ongwanada (Q-GLO), Ongwanada Resource Centre, Kingston, Ontario, Canada.
Guthrie JL; Public Health Ontario, Toronto, Ontario, Canada.
Mubareka S; Sunnybrook Health Science Centre, Division of Infectious Diseases, Toronto, Ontario, Canada.; Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Simpson JT; Ontario Institute for Cancer Research, Toronto, Ontario, Canada.; Department of Computer Science, University of Toronto, Toronto, Ontario, Canada.
Hamelin B; Ontario Genomics Institute, Toronto, Ontario, Canada.
Wong H; Division of Microbiology, Kingston Health Sciences Centre, Kingston, Ontario, Canada.
Mortimer L; Division of Microbiology, Eastern Ontario Regional Laboratories, Ottawa, Ontario, Canada.; Department of Laboratory Medicine and Pathology, CHEO, Ottawa, Ontario, Canada.; Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Slinger R; Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Department of Pediatrics, University of Ottawa, Ottawa, Ontario, Canada.
McArthur AG; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.; M.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.
Desjardins M; Division of Microbiology, Eastern Ontario Regional Laboratories, Ottawa, Ontario, Canada.; Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
McGeer A; Department of Microbiology, Mount Sinai Hospital, University Health Network, Toronto, Ontario, Canada.; Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada.
Mazzulli T; Public Health Ontario, Toronto, Ontario, Canada.; Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.; Department of Microbiology, Mount Sinai Hospital, University Health Network, Toronto, Ontario, Canada.
Douchant K; Department of Biomedical & Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
Brabant-Kirwan D; Division of Microbiology, Health Sciences North, Sudbury, Ontario, Canada.
Fattouh R; St. Michael's Unity Health, Toronto, Ontario, Canada.
Campigotto A; Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.; Hospital for Sick Children, Toronto, Ontario, Canada.
Patel SN; Public Health Ontario, Toronto, Ontario, Canada.; Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Fittipaldi N; Public Health Ontario, Toronto, Ontario, Canada.; Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.; Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada.
Colautti RI; Biology Department, Queen's University, Kingston, Ontario, Canada.
Sheth PM; Division of Microbiology, Kingston Health Sciences Centre, Kingston, Ontario, Canada.; Department of Biomedical & Molecular Sciences, Queen's University, Kingston, Ontario, Canada.; Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada.; Gastrointestinal Disease Research Unit, Kingston Health Sciences Center, Kingston, Ontario, Canada.
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Źródło :
MSphere [mSphere] 2021 May 05; Vol. 6 (3). Date of Electronic Publication: 2021 May 05.
Typ publikacji :
Journal Article
MeSH Terms :
Mutation Rate*
Genetic Variation/*genetics
Genome, Viral/*genetics
SARS-CoV-2/*genetics
Spike Glycoprotein, Coronavirus/*genetics
Base Sequence ; COVID-19/pathology ; Humans ; Ontario ; Phylogeny ; Sequence Analysis, RNA
Czasopismo naukowe
Tytuł :
The role of Mfd in Mycobacterium tuberculosis physiology and underlying regulatory network.
Autorzy :
Han S; Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Ministry of Education Eco-Environment of the Three Gorges Reservoir Region, Ministry of Education, Chongqing Municipal Key Laboratory of Karst Environment, School of Life Sciences, Southwest University, Beibei, Chongqing, 400715, China.
Gong Z; Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Ministry of Education Eco-Environment of the Three Gorges Reservoir Region, Ministry of Education, Chongqing Municipal Key Laboratory of Karst Environment, School of Life Sciences, Southwest University, Beibei, Chongqing, 400715, China.
Liang T; Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Ministry of Education Eco-Environment of the Three Gorges Reservoir Region, Ministry of Education, Chongqing Municipal Key Laboratory of Karst Environment, School of Life Sciences, Southwest University, Beibei, Chongqing, 400715, China.
Chen Y; Department of Tuberculosis, Shenyang Tenth People's Hospital and Shenyang Chest Hospital, Shenyang, Liaoning Province, 110044, China. Electronic address: .
Xie J; Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Ministry of Education Eco-Environment of the Three Gorges Reservoir Region, Ministry of Education, Chongqing Municipal Key Laboratory of Karst Environment, School of Life Sciences, Southwest University, Beibei, Chongqing, 400715, China. Electronic address: .
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Źródło :
Microbiological research [Microbiol Res] 2021 May; Vol. 246, pp. 126718. Date of Electronic Publication: 2021 Feb 03.
Typ publikacji :
Journal Article; Review
MeSH Terms :
DNA Repair*
Drug Discovery*
Mutation Rate*
Bacterial Proteins/*physiology
Mycobacterium tuberculosis/*physiology
Transcription Factors/*physiology
DNA, Bacterial ; DNA-Directed RNA Polymerases/physiology ; Drug Resistance, Bacterial ; Gene Expression Regulation, Bacterial ; Gene Regulatory Networks ; Humans ; Mutagenesis ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Mutation Rate Variability across Human Y-Chromosome Haplogroups.
Autorzy :
Ding Q; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY.
Hu Y; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY.; New York Genome Center, New York, NY.
Koren A; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY.
Clark AG; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY.; Department of Computational Biology, Cornell University, Ithaca, NY.
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Źródło :
Molecular biology and evolution [Mol Biol Evol] 2021 Mar 09; Vol. 38 (3), pp. 1000-1005.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Chromosomes, Human, Y*
Mutation Rate*
Germ-Line Mutation ; Haplotypes ; Humans ; Male ; Phylogeny
Czasopismo naukowe
Tytuł :
Benchmark dose analysis of multiple genotoxicity endpoints in gpt delta mice exposed to aristolochic acid I.
Autorzy :
Chen R; School of Public Health, Hongqiao International Institute of Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
You X; School of Public Health, Hongqiao International Institute of Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Cao Y; School of Public Health, Hongqiao International Institute of Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Masumura K; Division of Genetics and Mutagenesis, National Institute of Health Sciences, Tonomachi, Kawasaki-ku, Kawasaki City, Kanagawa, Japan.
Ando T; Division of Genetics and Mutagenesis, National Institute of Health Sciences, Tonomachi, Kawasaki-ku, Kawasaki City, Kanagawa, Japan.
Hamada S; Tokyo Laboratory BoZo Research Center Inc., Hanegi, Setagaya, Tokyo, Japan.
Horibata K; Division of Genetics and Mutagenesis, National Institute of Health Sciences, Tonomachi, Kawasaki-ku, Kawasaki City, Kanagawa, Japan.
Wan J; School of Public Health, Hongqiao International Institute of Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xi J; School of Public Health, Hongqiao International Institute of Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhang X; School of Public Health, Hongqiao International Institute of Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Honma M; Division of Genetics and Mutagenesis, National Institute of Health Sciences, Tonomachi, Kawasaki-ku, Kawasaki City, Kanagawa, Japan.
Luan Y; School of Public Health, Hongqiao International Institute of Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
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Źródło :
Mutagenesis [Mutagenesis] 2021 Apr 28; Vol. 36 (1), pp. 87-94.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Adducts*
DNA Damage*
Mutation Rate*
Aristolochic Acids/*toxicity
Escherichia coli Proteins/*metabolism
Pentosyltransferases/*metabolism
Animals ; Benchmarking ; Escherichia coli Proteins/genetics ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Micronucleus Tests ; Mutagenicity Tests ; Mutagens/toxicity ; Pentosyltransferases/genetics
Czasopismo naukowe
Tytuł :
Identification of NTRK3 as a potential prognostic biomarker associated with tumor mutation burden and immune infiltration in bladder cancer.
Autorzy :
Zhang Z; Department of Urology, The Affiliated Hospital of Qingdao University, No.16 Jiangsu Road, Qingdao, 266000, China.
Yu Y; Department of Urology, The Affiliated Hospital of Qingdao University, No.16 Jiangsu Road, Qingdao, 266000, China.
Zhang P; Department of Urology, The Affiliated Hospital of Qingdao University, No.16 Jiangsu Road, Qingdao, 266000, China.
Ma G; Department of Urology, The Affiliated Hospital of Qingdao University, No.16 Jiangsu Road, Qingdao, 266000, China.
Zhang M; Department of Urology, The Affiliated Hospital of Qingdao University, No.16 Jiangsu Road, Qingdao, 266000, China.
Liang Y; Key Laboratory, Department of Urology and Andrology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Jiao W; Department of Urology, The Affiliated Hospital of Qingdao University, No.16 Jiangsu Road, Qingdao, 266000, China. .
Niu H; Department of Urology, The Affiliated Hospital of Qingdao University, No.16 Jiangsu Road, Qingdao, 266000, China. .; Key Laboratory, Department of Urology and Andrology, The Affiliated Hospital of Qingdao University, Qingdao, China. .
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Źródło :
BMC cancer [BMC Cancer] 2021 Apr 24; Vol. 21 (1), pp. 458. Date of Electronic Publication: 2021 Apr 24.
Typ publikacji :
Journal Article
MeSH Terms :
Mutation Rate*
Biomarkers, Tumor/*genetics
Receptor, trkC/*genetics
Urinary Bladder Neoplasms/*genetics
Databases, Genetic ; Gene Expression Profiling ; Humans ; Kaplan-Meier Estimate ; Mutation ; Prognosis ; Proportional Hazards Models ; Transcriptome ; Urinary Bladder Neoplasms/immunology ; Urinary Bladder Neoplasms/mortality
Czasopismo naukowe
Tytuł :
Achromobacter xylosoxidans and Stenotrophomonas maltophilia : Emerging Pathogens Well-Armed for Life in the Cystic Fibrosis Patients' Lung.
Autorzy :
Menetrey Q; HydroSciences Montpellier, CNRS, IRD, Univ Montpellier, 34093 Montpellier, France.
Sorlin P; HydroSciences Montpellier, CNRS, IRD, Univ Montpellier, 34093 Montpellier, France.
Jumas-Bilak E; HydroSciences Montpellier, CNRS, IRD, Univ Montpellier, Department d'Hygiène Hospitalière, CHU Montpellier, 34093 Montpellier, France.
Chiron R; HydroSciences Montpellier, Université de Montpellier, CNRS, IRD, Centre de Ressources et de Compétences de la Mucoviscidose, CHU de Montpellier, 34093 Montpellier, France.
Dupont C; HydroSciences Montpellier, CNRS, IRD, Univ Montpellier, Department d'Hygiène Hospitalière, CHU Montpellier, 34093 Montpellier, France.
Marchandin H; HydroSciences Montpellier, CNRS, IRD, Univ Montpellier, Service de Microbiologie et Hygiène Hospitalière, CHU Nîmes, 34093 Nîmes, France.; UMR 5151 HydroSciences Montpellier, Equipe Pathogènes Hydriques Santé Environnements, U.F.R. des Sciences Pharmaceutiques et Biologiques, Université de Montpellier, 15, Avenue Charles Flahault, BP 14491, CEDEX 5, 34093 Montpellier, France.
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Źródło :
Genes [Genes (Basel)] 2021 Apr 21; Vol. 12 (5). Date of Electronic Publication: 2021 Apr 21.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Mutation Rate*
Achromobacter denitrificans/*genetics
Cystic Fibrosis/*microbiology
Gram-Negative Bacterial Infections/*microbiology
Stenotrophomonas maltophilia/*genetics
Achromobacter denitrificans/pathogenicity ; Adaptation, Physiological ; Cystic Fibrosis/complications ; Gram-Negative Bacterial Infections/complications ; Humans ; Lung/microbiology ; Stenotrophomonas maltophilia/pathogenicity
Czasopismo naukowe
Tytuł :
Mutagenic mechanisms of cancer-associated DNA polymerase ϵ alleles.
Autorzy :
Herzog M; The Wellcome/Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.; The Wellcome Sanger Institute, Hinxton CB10 1HH, UK.
Alonso-Perez E; Department of Chemistry and Molecular Biology, University of Gothenburg, Medicinaregatan 9 C, 413 90, Göteborg, Sweden.
Salguero I; The Wellcome/Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.
Warringer J; Department of Chemistry and Molecular Biology, University of Gothenburg, Medicinaregatan 9 C, 413 90, Göteborg, Sweden.
Adams DJ; The Wellcome Sanger Institute, Hinxton CB10 1HH, UK.
Jackson SP; The Wellcome/Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.
Puddu F; The Wellcome/Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Apr 19; Vol. 49 (7), pp. 3919-3931.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Colorectal Neoplasms*/enzymology
Colorectal Neoplasms*/genetics
DNA Polymerase II*/genetics
DNA Polymerase II*/metabolism
Mutation Rate*
Poly-ADP-Ribose Binding Proteins*/genetics
Poly-ADP-Ribose Binding Proteins*/metabolism
Saccharomyces cerevisiae Proteins*/genetics
Saccharomyces cerevisiae Proteins*/metabolism
DNA Replication ; Humans ; Mutagenesis ; Mutation ; Saccharomyces cerevisiae/enzymology ; Saccharomyces cerevisiae/genetics
Czasopismo naukowe
Tytuł :
Compartmentalized evolution of hepatitis B virus contributes differently to the prognosis of hepatocellular carcinoma.
Autorzy :
Yin J; Department of Epidemiology, Faculty of Navy Medicine, Second Military Medical University, 8 Panshan Rd, Yangpu District, Shanghai 200433, China.
Chen X; Department of Epidemiology, Faculty of Navy Medicine, Second Military Medical University, 8 Panshan Rd, Yangpu District, Shanghai 200433, China.
Li N; Department of Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 8 Panshan Rd, Yangpu District, Shanghai 200433, China.
Han X; Department of Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 8 Panshan Rd, Yangpu District, Shanghai 200433, China.
Liu W; Department of Epidemiology, Faculty of Navy Medicine, Second Military Medical University, 8 Panshan Rd, Yangpu District, Shanghai 200433, China.
Pu R; Department of Epidemiology, Faculty of Navy Medicine, Second Military Medical University, 8 Panshan Rd, Yangpu District, Shanghai 200433, China.
Wu T; Department of Epidemiology, Faculty of Navy Medicine, Second Military Medical University, 8 Panshan Rd, Yangpu District, Shanghai 200433, China.
Ding Y; Department of Epidemiology, Faculty of Navy Medicine, Second Military Medical University, 8 Panshan Rd, Yangpu District, Shanghai 200433, China.
Zhang H; Department of Epidemiology, Faculty of Navy Medicine, Second Military Medical University, 8 Panshan Rd, Yangpu District, Shanghai 200433, China.
Zhao J; Department of Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 8 Panshan Rd, Yangpu District, Shanghai 200433, China.
Han X; Division of Chronic Diseases, Center for Disease Control and Prevention of Yangpu District, Shanghai, China.
Wang H; Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer, Ministry of Education, Shanghai, China.; Shanghai Key Laboratory of Hepatobiliary Tumor Biology, Shanghai, China.
Cheng S; Department of Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 8 Panshan Rd, Yangpu District, Shanghai 200433, China.; Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer, Ministry of Education, Shanghai, China.; Shanghai Key Laboratory of Hepatobiliary Tumor Biology, Shanghai, China.
Cao G; Department of Epidemiology, Faculty of Navy Medicine, Second Military Medical University, 8 Panshan Rd, Yangpu District, Shanghai 200433, China.; Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer, Ministry of Education, Shanghai, China.; Shanghai Key Laboratory of Hepatobiliary Tumor Biology, Shanghai, China.
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Źródło :
Carcinogenesis [Carcinogenesis] 2021 Apr 17; Vol. 42 (3), pp. 461-470.
Typ publikacji :
Journal Article; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation Rate*
Carcinoma, Hepatocellular/*mortality
Hepatitis B virus/*genetics
Hepatitis B, Chronic/*mortality
Liver Neoplasms/*mortality
Neoplasm Recurrence, Local/*epidemiology
Adult ; Antiviral Agents/therapeutic use ; Carcinoma, Hepatocellular/blood ; Carcinoma, Hepatocellular/therapy ; Carcinoma, Hepatocellular/virology ; DNA Mutational Analysis ; DNA, Viral/analysis ; DNA, Viral/genetics ; DNA, Viral/isolation & purification ; Datasets as Topic ; Disease-Free Survival ; Female ; Follow-Up Studies ; Hepatectomy ; Hepatitis B virus/isolation & purification ; Hepatitis B, Chronic/blood ; Hepatitis B, Chronic/therapy ; Hepatitis B, Chronic/virology ; Humans ; Liver/pathology ; Liver/surgery ; Liver/virology ; Liver Neoplasms/blood ; Liver Neoplasms/therapy ; Liver Neoplasms/virology ; Male ; Middle Aged ; Neoplasm Recurrence, Local/virology ; Prognosis ; Prospective Studies ; Risk Assessment/methods
Czasopismo naukowe
Tytuł :
Molecular and Genetic Mechanism of Non-Syndromic Congenital Cataracts. Mutation Screening in Spanish Families.
Autorzy :
Fernández-Alcalde C; Department of Ophthalmology, Hospital Universitario La Paz, 28046 Madrid, Spain.
Nieves-Moreno M; Department of Ophthalmology, Hospital Universitario La Paz, 28046 Madrid, Spain.
Noval S; Department of Ophthalmology, Hospital Universitario La Paz, 28046 Madrid, Spain.
Peralta JM; Department of Ophthalmology, Hospital Universitario La Paz, 28046 Madrid, Spain.
Montaño VEF; Department of Molecular Ophthalmology, Medical and Molecular Genetics Institute (INGEMM) IdiPaz, CIBERER, Hospital Universitario La Paz, 28046 Madrid, Spain.
Del Pozo Á; Department of Clinical Bioinformatics, Medical and Molecular Genetics Institute (INGEMM) IdiPaz, CIBERER, Hospital Universitario La Paz, 28046 Madrid, Spain.
Santos-Simarro F; Department of Clinical Genetics, Medical and Molecular Genetics Institute (INGEMM) IdiPaz, CIBERER, Hospital Universitario La Paz, 28046 Madrid, Spain.
Vallespín E; Department of Molecular Ophthalmology, Medical and Molecular Genetics Institute (INGEMM) IdiPaz, CIBERER, Hospital Universitario La Paz, 28046 Madrid, Spain.
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Źródło :
Genes [Genes (Basel)] 2021 Apr 16; Vol. 12 (4). Date of Electronic Publication: 2021 Apr 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Regulatory Networks*
Mutation Rate*
Cataract/*congenital
DNA Mutational Analysis/*methods
Cataract/genetics ; Female ; Genetic Predisposition to Disease ; High-Throughput Nucleotide Sequencing ; Humans ; Male ; Pedigree ; Sequence Analysis, DNA ; Spain
Czasopismo naukowe
Tytuł :
Estimating divergence times from DNA sequences.
Autorzy :
Sjödin P; Human Evolution, Department of Organismal Biology, Uppsala University, Norbyvägen 18 A, Uppsala 752 36, Sweden.
McKenna J; Human Evolution, Department of Organismal Biology, Uppsala University, Norbyvägen 18 A, Uppsala 752 36, Sweden.
Jakobsson M; Human Evolution, Department of Organismal Biology, Uppsala University, Norbyvägen 18 A, Uppsala 752 36, Sweden.; Science for Life Laboratory, Uppsala University, Norbyvägen 18 A, Uppsala 752 36, Sweden.
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Źródło :
Genetics [Genetics] 2021 Apr 15; Vol. 217 (4).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation Rate*
Polymorphism, Genetic*
Population/*genetics
Animals ; DNA, Ancient ; Genetic Drift ; Humans ; Neanderthals/genetics ; Time
Czasopismo naukowe
Tytuł :
ATP-Dependent Ligases and AEP Primases Affect the Profile and Frequency of Mutations in Mycobacteria under Oxidative Stress.
Autorzy :
Brzostek A; Laboratory of Genetics and Physiology of Mycobacterium, Institute of Medical Biology of the Polish Academy of Sciences, 93-232 Lodz, Poland.
Gąsior F; Laboratory of Genetics and Physiology of Mycobacterium, Institute of Medical Biology of the Polish Academy of Sciences, 93-232 Lodz, Poland.; BioMedChem Doctoral School of the University of Lodz and the Institutes of the Polish Academy of Sciences in Lodz, 90-237 Lodz, Poland.
Lach J; Biobank Lab, Department of Molecular Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, 90-237 Lodz, Poland.
Żukowska L; Laboratory of Genetics and Physiology of Mycobacterium, Institute of Medical Biology of the Polish Academy of Sciences, 93-232 Lodz, Poland.; BioMedChem Doctoral School of the University of Lodz and the Institutes of the Polish Academy of Sciences in Lodz, 90-237 Lodz, Poland.
Lechowicz E; Laboratory of Genetics and Physiology of Mycobacterium, Institute of Medical Biology of the Polish Academy of Sciences, 93-232 Lodz, Poland.; Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Lodz, 90-237 Lodz, Poland.
Korycka-Machała M; Laboratory of Genetics and Physiology of Mycobacterium, Institute of Medical Biology of the Polish Academy of Sciences, 93-232 Lodz, Poland.
Strapagiel D; Biobank Lab, Department of Molecular Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, 90-237 Lodz, Poland.
Dziadek J; Laboratory of Genetics and Physiology of Mycobacterium, Institute of Medical Biology of the Polish Academy of Sciences, 93-232 Lodz, Poland.
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Źródło :
Genes [Genes (Basel)] 2021 Apr 09; Vol. 12 (4). Date of Electronic Publication: 2021 Apr 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation Rate*
Oxidative Stress*
Adenosine Triphosphate/*metabolism
Bacterial Proteins/*metabolism
DNA Primase/*metabolism
Ligases/*metabolism
Mycobacterium/*genetics
Bacterial Proteins/genetics ; DNA Primase/genetics ; Ligases/genetics ; Mycobacterium/growth & development ; Mycobacterium/metabolism
Czasopismo naukowe
Tytuł :
Folate Intake Alters Mutation Frequency and Profiles in a Tissue- and Dose-Specific Manner in MutaMouse Male Mice.
Autorzy :
Diaz G S; Nutrition Research Division, Health Canada, Ottawa, Canada.; Department of Biology, Carleton University, Ottawa, Canada.
LeBlanc DP; Nutrition Research Division, Health Canada, Ottawa, Canada.
Gagné R; Environmental Health Science and Research Bureau, Health Canada, Ottawa, Canada.
Behan NA; Department of Biology, Carleton University, Ottawa, Canada.
Wong A; Department of Biology, Carleton University, Ottawa, Canada.
Marchetti F; Department of Biology, Carleton University, Ottawa, Canada.; Environmental Health Science and Research Bureau, Health Canada, Ottawa, Canada.
MacFarlane AJ; Nutrition Research Division, Health Canada, Ottawa, Canada.; Department of Biology, Carleton University, Ottawa, Canada.
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Źródło :
The Journal of nutrition [J Nutr] 2021 Apr 08; Vol. 151 (4), pp. 800-809.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation Rate*
Folic Acid/*administration & dosage
Animals ; Bone Marrow/drug effects ; Bone Marrow/metabolism ; Colon/drug effects ; Colon/metabolism ; Dose-Response Relationship, Drug ; Folic Acid/adverse effects ; Folic Acid/blood ; Folic Acid Deficiency/blood ; Folic Acid Deficiency/genetics ; High-Throughput Nucleotide Sequencing ; Lac Operon/drug effects ; Male ; Mice ; Mice, Mutant Strains ; Mice, Transgenic ; Mutagenesis ; Organ Specificity
Czasopismo naukowe

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