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Wyszukujesz frazę ""Mycobacterium tuberculosis"" wg kryterium: Temat


Tytuł:
Novel rrs mutations in second-line injectable drug-resistant clinical isolates of Mycobacterium tuberculosis from the Punjab province of Pakistan.
Autorzy:
Sarwer MI; Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore. 1KM Defense Road, Lahore, 58810, Pakistan. Electronic address: .
Khan MT; Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore. 1KM Defense Road, Lahore, 58810, Pakistan. Electronic address: .
Khurshid S; Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore. 1KM Defense Road, Lahore, 58810, Pakistan. Electronic address: sanakhurshid_.
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Źródło:
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy [J Infect Chemother] 2022 Aug; Vol. 28 (8), pp. 1119-1124. Date of Electronic Publication: 2022 Apr 12.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Resistance, Multiple, Bacterial*/genetics
Mycobacterium tuberculosis*/genetics
Mycobacterium tuberculosis*/isolation & purification
Tuberculosis, Multidrug-Resistant*/drug therapy
Tuberculosis, Multidrug-Resistant*/genetics
Antitubercular Agents/adverse effects ; Antitubercular Agents/pharmacology ; Antitubercular Agents/therapeutic use ; Genes, Bacterial/genetics ; Humans ; Microbial Sensitivity Tests ; Mutation ; Pakistan ; Rifampin/pharmacology ; Rifampin/therapeutic use ; Tuberculosis, Lymph Node
Czasopismo naukowe
Tytuł:
Class Ⅰ histone deacetylase inhibitor regulate of Mycobacteria-Driven guanylate-binding protein 1 gene expression.
Autorzy:
Wei M; School of Life Science, Anhui Province Key Laboratory of Translational Cancer Research, Anhui Province Key Laboratory of Immunology in Chronic Diseases, Anhui Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu, Anhui, 233030, China; Anhui Province Key Laboratory of Local Livestock and Poultry Genetic Resource Conservation and Bio-breeding, College of Animal Science and Technology, Anhui Agricultural University, Hefei, 230036, China. Electronic address: .
Qin Y; School of Life Science, Anhui Province Key Laboratory of Translational Cancer Research, Anhui Province Key Laboratory of Immunology in Chronic Diseases, Anhui Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu, Anhui, 233030, China.
Qian K; School of Life Science, Anhui Province Key Laboratory of Translational Cancer Research, Anhui Province Key Laboratory of Immunology in Chronic Diseases, Anhui Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu, Anhui, 233030, China.
Shang S; School of Life Science, Anhui Province Key Laboratory of Translational Cancer Research, Anhui Province Key Laboratory of Immunology in Chronic Diseases, Anhui Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu, Anhui, 233030, China.
Zhao Y; School of Life Science, Anhui Province Key Laboratory of Translational Cancer Research, Anhui Province Key Laboratory of Immunology in Chronic Diseases, Anhui Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu, Anhui, 233030, China.
Xie T; School of Life Science, Anhui Province Key Laboratory of Translational Cancer Research, Anhui Province Key Laboratory of Immunology in Chronic Diseases, Anhui Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu, Anhui, 233030, China.
Xi J; School of Life Science, Anhui Province Key Laboratory of Translational Cancer Research, Anhui Province Key Laboratory of Immunology in Chronic Diseases, Anhui Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu, Anhui, 233030, China.
Tang B; School of Life Science, Anhui Province Key Laboratory of Translational Cancer Research, Anhui Province Key Laboratory of Immunology in Chronic Diseases, Anhui Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu, Anhui, 233030, China. Electronic address: .
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Źródło:
Microbial pathogenesis [Microb Pathog] 2022 Aug; Vol. 169, pp. 105655. Date of Electronic Publication: 2022 Jun 23.
Typ publikacji:
Journal Article
MeSH Terms:
Mycobacterium Infections*
Mycobacterium tuberculosis*/genetics
Mycobacterium tuberculosis*/metabolism
GTP-Binding Proteins/*metabolism
Cytokines/metabolism ; Gene Expression ; Histone Deacetylase Inhibitors/pharmacology ; Humans
Czasopismo naukowe
Tytuł:
The ΔCysK 2 mutant of Mycobacterium tuberculosis is sensitive to vancomycin associated with changes in cell wall phospholipid profile.
Autorzy:
Sao Emani C; Division of Infectious Diseases, Department of Medicine/Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: .
Richter A; Martin-Luther-University of Halle-Wittenberg, Kurt-Mothes-Straße 3, 06120, Halle, Germany.
Singh A; School of Biosciences and Institute of Microbiology and Infection, University of Birmingham, Birmingham, B15 2TT, UK.
Bhatt A; School of Biosciences and Institute of Microbiology and Infection, University of Birmingham, Birmingham, B15 2TT, UK.
Av-Gay Y; Division of Infectious Diseases, Department of Medicine/Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: .
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Źródło:
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2022 Oct 08; Vol. 624, pp. 120-126. Date of Electronic Publication: 2022 Aug 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mycobacterium tuberculosis*/genetics
Cell Wall ; Cysteine/genetics ; Phospholipids ; Vancomycin/pharmacology
Czasopismo naukowe
Tytuł:
Predicting antibiotic resistance in complex protein targets using alchemical free energy methods.
Autorzy:
Brankin AE; Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Fowler PW; Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.; National Institute of Health Research Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK.
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Źródło:
Journal of computational chemistry [J Comput Chem] 2022 Oct 05; Vol. 43 (26), pp. 1771-1782. Date of Electronic Publication: 2022 Aug 25.
Typ publikacji:
Journal Article
MeSH Terms:
Mycobacterium tuberculosis*/genetics
Mycobacterium tuberculosis*/metabolism
Tuberculosis*/drug therapy
Tuberculosis*/microbiology
DNA Gyrase/genetics ; DNA Gyrase/metabolism ; DNA Gyrase/pharmacology ; Drug Resistance, Microbial ; Humans ; Moxifloxacin/pharmacology ; Moxifloxacin/therapeutic use ; Mutation
Czasopismo naukowe
Tytuł:
Structural insights of the elongation factor EF-Tu complexes in protein translation of Mycobacterium tuberculosis.
Autorzy:
Zhan B; State Key Laboratory of Genetic Engineering, School of Life Sciences, Shanghai Engineering Research Center of Industrial Microorganisms, Fudan University, 200438, Shanghai, China.
Gao Y; State Key Laboratory of Genetic Engineering, School of Life Sciences, Shanghai Engineering Research Center of Industrial Microorganisms, Fudan University, 200438, Shanghai, China.
Gao W; State Key Laboratory of Genetic Engineering, School of Life Sciences, Shanghai Engineering Research Center of Industrial Microorganisms, Fudan University, 200438, Shanghai, China.
Li Y; State Key Laboratory of Genetic Engineering, School of Life Sciences, Shanghai Engineering Research Center of Industrial Microorganisms, Fudan University, 200438, Shanghai, China.
Li Z; State Key Laboratory of Genetic Engineering, School of Life Sciences, Shanghai Engineering Research Center of Industrial Microorganisms, Fudan University, 200438, Shanghai, China.
Qi Q; State Key Laboratory of Genetic Engineering, School of Life Sciences, Shanghai Engineering Research Center of Industrial Microorganisms, Fudan University, 200438, Shanghai, China.
Lan X; State Key Laboratory of Genetic Engineering, School of Life Sciences, Shanghai Engineering Research Center of Industrial Microorganisms, Fudan University, 200438, Shanghai, China.
Shen H; Shanghai Clinical Research Center for Infectious Disease (tuberculosis), Shanghai Pulmonary Hospital, Tongji University School of Medicine, 200433, Shanghai, China.
Gan J; State Key Laboratory of Genetic Engineering, School of Life Sciences, Shanghai Engineering Research Center of Industrial Microorganisms, Fudan University, 200438, Shanghai, China.
Zhao G; Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, 200031, Shanghai, China. .
Li J; State Key Laboratory of Genetic Engineering, School of Life Sciences, Shanghai Engineering Research Center of Industrial Microorganisms, Fudan University, 200438, Shanghai, China. .; Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University, 200040, Shanghai, China. .
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Źródło:
Communications biology [Commun Biol] 2022 Oct 03; Vol. 5 (1), pp. 1052. Date of Electronic Publication: 2022 Oct 03.
Typ publikacji:
Journal Article
MeSH Terms:
Mycobacterium tuberculosis*/genetics
Mycobacterium tuberculosis*/metabolism
Peptide Elongation Factor Tu*/genetics
Peptide Elongation Factor Tu*/metabolism
BCG Vaccine ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Guanosine Diphosphate/chemistry ; Guanosine Diphosphate/metabolism ; Peptide Elongation Factors/chemistry ; Peptide Elongation Factors/genetics ; Peptide Elongation Factors/metabolism ; Protein Biosynthesis ; Scattering, Small Angle ; X-Ray Diffraction
Czasopismo naukowe
Tytuł:
Novel HLA associations with outcomes of Mycobacterium tuberculosis exposure and sarcoidosis in individuals of African ancestry using nearest-neighbor feature selection.
Autorzy:
Dawkins BA; Department of Genes and Human Disease, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.
Garman L; Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Cejda N; Department of Genes and Human Disease, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.
Pezant N; Department of Genes and Human Disease, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.
Rasmussen A; Department of Genes and Human Disease, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.
Rybicki BA; Department of Public Health Sciences, Henry Ford Health System, Detroit, Michigan, USA.
Levin AM; Department of Public Health Sciences, Henry Ford Health System, Detroit, Michigan, USA.; Center for Bioinformatics, Henry Ford Health System, Detroit, Michigan, USA.
Benchek P; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA.
Seshadri C; Department of Medicine, University of Washington, Seattle, Washington, USA.
Mayanja-Kizza H; Department of Medicine, Makerere University and Mulago Hospital, Kampala, Uganda.
Iannuzzi MC; Department of Public Health Sciences, Henry Ford Health System, Detroit, Michigan, USA.
Stein CM; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA.; Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Montgomery CG; Department of Genes and Human Disease, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.
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Źródło:
Genetic epidemiology [Genet Epidemiol] 2022 Oct; Vol. 46 (7), pp. 463-474. Date of Electronic Publication: 2022 Jun 14.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Mycobacterium tuberculosis*/genetics
Sarcoidosis*/genetics
Tuberculosis*/genetics
Alleles ; Gene Frequency ; Genetic Predisposition to Disease ; HLA-DRB1 Chains/genetics ; Humans
Czasopismo naukowe
Tytuł:
High-throughput strategy for identification of Mycobacterium tuberculosis membrane protein expression conditions using folding reporter GFP.
Autorzy:
Grāve K; Department of Biochemistry and Biophysics, Stockholm University. Svante Arrhenius väg 16C, SE-10691, Stockholm, Sweden.
Bennett MD; Department of Biochemistry and Biophysics, Stockholm University. Svante Arrhenius väg 16C, SE-10691, Stockholm, Sweden.
Högbom M; Department of Biochemistry and Biophysics, Stockholm University. Svante Arrhenius väg 16C, SE-10691, Stockholm, Sweden. Electronic address: .
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Źródło:
Protein expression and purification [Protein Expr Purif] 2022 Oct; Vol. 198, pp. 106132. Date of Electronic Publication: 2022 Jun 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mycobacterium tuberculosis*/genetics
Mycobacterium tuberculosis*/metabolism
Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mycobacterium smegmatis/genetics ; Mycobacterium smegmatis/metabolism ; Promoter Regions, Genetic
Czasopismo naukowe
Tytuł:
Systemic prime exacerbates the ocular immune response to heat-killed Mycobacterium tuberculosis.
Autorzy:
Pepple KL; University of Washington, Department of Ophthalmology, Seattle, WA, 98104, USA; University of Washington, Roger and Angie Karalis Johnson Retina Center, Seattle, WA, 98109, USA. Electronic address: .
John S; University of Washington, Department of Ophthalmology, Seattle, WA, 98104, USA.
Wilson L; University of Washington, Department of Ophthalmology, Seattle, WA, 98104, USA.
Wang V; University of Washington, Department of Ophthalmology, Seattle, WA, 98104, USA.
Van Gelder RN; University of Washington, Department of Ophthalmology, Seattle, WA, 98104, USA; University of Washington, Department of Biological Structure, Seattle, WA, 98195, USA; University of Washington, Department of Laboratory Medicine and Pathology, Seattle, WA, 98195, USA; University of Washington, Roger and Angie Karalis Johnson Retina Center, Seattle, WA, 98109, USA.
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Źródło:
Experimental eye research [Exp Eye Res] 2022 Oct; Vol. 223, pp. 109198. Date of Electronic Publication: 2022 Jul 31.
Typ publikacji:
Journal Article
MeSH Terms:
Mycobacterium tuberculosis*
Uveitis*
Animals ; Chemokine CCL3 ; Chemokine CXCL10 ; Cytokines ; Hot Temperature ; Immunity ; Inflammation ; Interleukin-12 Subunit p40 ; Interleukin-17 ; Mice ; Vascular Endothelial Growth Factor A
Czasopismo naukowe
Tytuł:
External quality assessment by European mycobacterial laboratories: results of AFB microscopy and identification rounds.
Autorzy:
Mentula S; Finnish Institute for Health and Welfare, Dept. Health Security, Mycobacterial Reference Laboratory, Helsinki, Finland. Electronic address: .
Paakkanen J; Labquality, Helsinki, Finland.
Hyyryläinen HL; Finnish Institute for Health and Welfare, Dept. Health Security, Mycobacterial Reference Laboratory, Helsinki, Finland.
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Źródło:
Diagnostic microbiology and infectious disease [Diagn Microbiol Infect Dis] 2022 Oct; Vol. 104 (2), pp. 115757. Date of Electronic Publication: 2022 Jun 30.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Mycobacterium Infections, Nontuberculous*/diagnosis
Mycobacterium Infections, Nontuberculous*/microbiology
Mycobacterium tuberculosis*
Humans ; Laboratories ; Microscopy ; Nontuberculous Mycobacteria ; Sputum/microbiology
Czasopismo naukowe
Tytuł:
Drug screening approach against mycobacterial fatty acyl-AMP ligase FAAL32 renews the interest of the salicylanilide pharmacophore in the fight against tuberculosis.
Autorzy:
Le NH; Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France.
Constant P; Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France.
Tranier S; Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France.
Nahoum V; Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France.
Guillet V; Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France.
Maveyraud L; Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France.
Daffé M; Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France.
Mourey L; Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France. Electronic address: .
Verhaeghe P; Laboratoire de Chimie de Coordination (LCC), Université de Toulouse, CNRS, UPS, Toulouse, France; CHU de Nîmes, Service de Pharmacie, Nîmes, France. Electronic address: .
Marrakchi H; Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France. Electronic address: .
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Źródło:
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2022 Oct 01; Vol. 71, pp. 116938. Date of Electronic Publication: 2022 Jul 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mycobacterium tuberculosis*
Tuberculosis*/drug therapy
Tuberculosis*/microbiology
Adenosine Monophosphate/therapeutic use ; Antitubercular Agents/chemistry ; Drug Evaluation, Preclinical ; Humans ; Salicylanilides
Czasopismo naukowe
Tytuł:
mTOR-regulated mitochondrial metabolism limits mycobacterium-induced cytotoxicity.
Autorzy:
Pagán AJ; Molecular Immunity Unit, Cambridge Institute of Therapeutic Immunology and Infectious Diseases, Department of Medicine, University of Cambridge, Cambridge CB2 0AW, UK; MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK; Department of Microbiology, University of Washington, Seattle, WA 98195, USA. Electronic address: .
Lee LJ; Molecular Immunity Unit, Cambridge Institute of Therapeutic Immunology and Infectious Diseases, Department of Medicine, University of Cambridge, Cambridge CB2 0AW, UK; MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Edwards-Hicks J; Max Planck Institute of Immunobiology and Epigenetics, Freiburg im Breisgau, Germany.
Moens CB; Division of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Tobin DM; Department of Microbiology, University of Washington, Seattle, WA 98195, USA.
Busch-Nentwich EM; Molecular Immunity Unit, Cambridge Institute of Therapeutic Immunology and Infectious Diseases, Department of Medicine, University of Cambridge, Cambridge CB2 0AW, UK.
Pearce EL; Max Planck Institute of Immunobiology and Epigenetics, Freiburg im Breisgau, Germany.
Ramakrishnan L; Molecular Immunity Unit, Cambridge Institute of Therapeutic Immunology and Infectious Diseases, Department of Medicine, University of Cambridge, Cambridge CB2 0AW, UK; MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK; Department of Microbiology, University of Washington, Seattle, WA 98195, USA. Electronic address: .
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Źródło:
Cell [Cell] 2022 Sep 29; Vol. 185 (20), pp. 3720-3738.e13. Date of Electronic Publication: 2022 Sep 13.
Typ publikacji:
Journal Article
MeSH Terms:
Mycobacterium marinum*
Mycobacterium tuberculosis*/metabolism
Tuberculosis*
Animals ; TOR Serine-Threonine Kinases/metabolism ; Zebrafish
Czasopismo naukowe
Tytuł:
Recent Transmission and Prevalent Characterization of the Beijing Family Mycobacterium tuberculosis in Jiangxi, China.
Autorzy:
Luo D; Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Yu S; Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Huang Y; Queen Mary College, Jiangxi Medical College, Nanchang University, Nanchang, China.
Zhan J; Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Chen Q; Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Yan L; Department of Clinical Laboratory, Jiangxi Provincial Chest Hospital, Nanchang, China.
Chen K; Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, China.
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Źródło:
Polish journal of microbiology [Pol J Microbiol] 2022 Sep 24; Vol. 71 (3), pp. 371-380. Date of Electronic Publication: 2022 Sep 24 (Print Publication: 2022).
Typ publikacji:
Journal Article
MeSH Terms:
Mycobacterium tuberculosis*/genetics
Tuberculosis*/epidemiology
Tuberculosis*/microbiology
Tuberculosis, Multidrug-Resistant*/epidemiology
China/epidemiology ; Genotype ; Humans
Czasopismo naukowe
Tytuł:
Psychological stress creates an immune suppressive environment in the lung that increases susceptibility of aged mice to Mycobacterium tuberculosis infection.
Autorzy:
Lafuse WP; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, United States.
Wu Q; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, United States.
Kumar N; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, United States.
Saljoughian N; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, United States.
Sunkum S; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, United States.
Ahumada OS; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, United States.
Turner J; Host Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, TX, United States.
Rajaram MVS; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, United States.
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Źródło:
Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2022 Sep 16; Vol. 12, pp. 990402. Date of Electronic Publication: 2022 Sep 16 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Mycobacterium tuberculosis*
Tuberculosis*
Animals ; Cytokines/metabolism ; Integrin alpha2 ; Interleukin-10/genetics ; Lung/metabolism ; Mice ; RNA, Messenger ; Stress, Psychological
Czasopismo naukowe
Tytuł:
Mycobacterium tuberculosis KasA as a drug target: Structure-based inhibitor design.
Autorzy:
Rudraraju RS; Department of Microbiology, Biochemistry and Molecular Genetics, New Jersey Medical School, Rutgers University, Newark, NJ, United States.
Daher SS; Department of Pharmacology, Physiology, and Neuroscience, New Jersey Medical School, Rutgers University, Newark, NJ, United States.
Gallardo-Macias R; Department of Pharmacology, Physiology, and Neuroscience, New Jersey Medical School, Rutgers University, Newark, NJ, United States.
Wang X; Department of Immunology and Infectious Diseases, Harvard University T.H. Chan School of Public Health, Boston, MA, United States.
Neiditch MB; Department of Microbiology, Biochemistry and Molecular Genetics, New Jersey Medical School, Rutgers University, Newark, NJ, United States.
Freundlich JS; Department of Pharmacology, Physiology, and Neuroscience, New Jersey Medical School, Rutgers University, Newark, NJ, United States.; Department of Medicine, Center for Emerging and Re-emerging Pathogens, New Jersey Medical School, Rutgers University, Newark, NJ, United States.
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Źródło:
Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2022 Sep 15; Vol. 12, pp. 1008213. Date of Electronic Publication: 2022 Sep 15 (Print Publication: 2022).
Typ publikacji:
Journal Article; Review; Research Support, N.I.H., Extramural
MeSH Terms:
3-Oxoacyl-(Acyl-Carrier-Protein) Synthase*/chemistry
3-Oxoacyl-(Acyl-Carrier-Protein) Synthase*/metabolism
Mycobacterium tuberculosis*/metabolism
Acyl Carrier Protein ; Antitubercular Agents/pharmacology ; Bacterial Proteins/metabolism
Czasopismo naukowe
Tytuł:
Discovery and preclinical evaluations of JBD0131, a novel nitrodihydro-imidazooxazole anti-tuberculosis agent.
Autorzy:
Luo W; WuXi AppTec, 666 Gaoxin Road, East Lake High-tech Development Zone, Wuhan 430075, China.
Huang Z; WuXi AppTec, 666 Gaoxin Road, East Lake High-tech Development Zone, Wuhan 430075, China.
Xu D; WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China.
Yang M; WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China.
Zhu Y; WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China.
Shen L; WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China.
Chen S; WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China.
Tao X; Changzhou Yinsheng Pharmacy Co., Ltd., Weitang Chemical Industry Zone, Changzhou 213000, China.
Bin W; Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Beijing Tuberculosis, and Thoracic Tumor Research Institute, Beijing, China.
Hu Y; WuXi AppTec, 666 Gaoxin Road, East Lake High-tech Development Zone, Wuhan 430075, China.
Franzblau SG; Institute for Tuberculosis Research, College of Pharmacy, The University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, United States.
Jiang N; Jumbo Drug Bank Co., Ltd., No.18, Section 2, Bio-city Middle Road, High-tech Zone, Chengdu, Sichuan 610000, China.
Wei Y; State Key Lab of Biotherapy, Sichuan University, No 17, The Third Renmin South Road, Chengdu, Sichuan 610041, China.
Wei X; Jumbo Drug Bank Co., Ltd., No.18, Section 2, Bio-city Middle Road, High-tech Zone, Chengdu, Sichuan 610000, China. Electronic address: .
Ding CZ; WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China. Electronic address: charles_.
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Źródło:
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2022 Sep 15; Vol. 72, pp. 128871. Date of Electronic Publication: 2022 Jun 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mycobacterium tuberculosis*
Nitroimidazoles*/pharmacology
Nitroimidazoles*/therapeutic use
Tuberculosis, Multidrug-Resistant*/drug therapy
Tuberculosis, Pulmonary*/drug therapy
Tuberculosis, Pulmonary*/microbiology
Antitubercular Agents/pharmacology ; Antitubercular Agents/therapeutic use ; Humans ; Oxazoles/pharmacology ; Oxazoles/therapeutic use
Czasopismo naukowe
Tytuł:
Reversing BCG-mediated autophagy inhibition and mycobacterial survival to improve vaccine efficacy.
Autorzy:
Gonzalez-Orozco M; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Strong EJ; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Paroha R; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Lee S; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA. .
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Źródło:
BMC immunology [BMC Immunol] 2022 Sep 14; Vol. 23 (1), pp. 43. Date of Electronic Publication: 2022 Sep 14.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Mycobacterium tuberculosis*
Vaccine Efficacy*
Autophagy/physiology ; BCG Vaccine ; Macrophages
Czasopismo naukowe
Tytuł:
Cephem-Pyrazinoic Acid Conjugates: Circumventing Resistance in Mycobacterium tuberculosis.
Autorzy:
Cole MS; Department of Medicinal Chemistry, University of Minnesota, 308 Harvard St SE, Minneapolis, Minnesota 55455, USA.
Howe MD; Department of Microbiology, Immunology, University of Minnesota Medical School, 689 23rd Ave SE, Minneapolis, Minnesota 55455, USA.
Buonomo JA; Department of Medicinal Chemistry, University of Minnesota, 308 Harvard St SE, Minneapolis, Minnesota 55455, USA.
Sharma S; Department of Medicinal Chemistry, University of Minnesota, 308 Harvard St SE, Minneapolis, Minnesota 55455, USA.
Lamont EA; Department of Microbiology, Immunology, University of Minnesota Medical School, 689 23rd Ave SE, Minneapolis, Minnesota 55455, USA.
Brody SI; Department of Medicinal Chemistry, University of Minnesota, 308 Harvard St SE, Minneapolis, Minnesota 55455, USA.
Mishra NK; Department of Medicinal Chemistry, University of Minnesota, 308 Harvard St SE, Minneapolis, Minnesota 55455, USA.; Department of Biotechnology, Gandhi Institute of Technology and Management (GITAM) School of Science, Deemed to be University, Gandhi nagar, Rushikonda, Visakhapatnam-530045, Andhra Pradesh, India.
Minato Y; Department of Microbiology, Immunology, University of Minnesota Medical School, 689 23rd Ave SE, Minneapolis, Minnesota 55455, USA.; Department of Microbiology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan.
Thiede JM; Department of Microbiology, Immunology, University of Minnesota Medical School, 689 23rd Ave SE, Minneapolis, Minnesota 55455, USA.
Baughn AD; Department of Microbiology, Immunology, University of Minnesota Medical School, 689 23rd Ave SE, Minneapolis, Minnesota 55455, USA.
Aldrich CC; Department of Medicinal Chemistry, University of Minnesota, 308 Harvard St SE, Minneapolis, Minnesota 55455, USA.
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Źródło:
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2022 Sep 12; Vol. 28 (51), pp. e202200995. Date of Electronic Publication: 2022 Jul 27.
Typ publikacji:
Journal Article
MeSH Terms:
Mycobacterium tuberculosis*
Tuberculosis*/drug therapy
Tuberculosis*/microbiology
Antitubercular Agents/pharmacology ; Antitubercular Agents/therapeutic use ; Humans ; Microbial Sensitivity Tests ; Pyrazinamide/analogs & derivatives ; Pyrazinamide/pharmacology ; beta-Lactams/pharmacology
Czasopismo naukowe
Tytuł:
How Mycobacterium tuberculosis drug resistance has shaped anti-tubercular drug discovery.
Autorzy:
Bhagwat A; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, United States.
Deshpande A; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, United States.
Parish T; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, United States.
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Źródło:
Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2022 Sep 09; Vol. 12, pp. 974101. Date of Electronic Publication: 2022 Sep 09 (Print Publication: 2022).
Typ publikacji:
Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Mycobacterium tuberculosis*
Tuberculosis, Lymph Node*
Antitubercular Agents/pharmacology ; Antitubercular Agents/therapeutic use ; Drug Discovery ; Drug Resistance ; Humans
Czasopismo naukowe
Tytuł:
Identification of Small Molecule Inhibitors against Mycobacteria in Activated Macrophages.
Autorzy:
Vande Voorde R; Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA.
Dzalamidze E; Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA.
Nelson D; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, USA.
Danelishvili L; Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA.; Department of Microbiology, College of Science, Oregon State University, Corvallis, OR 97331, USA.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Sep 08; Vol. 27 (18). Date of Electronic Publication: 2022 Sep 08.
Typ publikacji:
Journal Article
MeSH Terms:
Mycobacterium Infections, Nontuberculous*/drug therapy
Mycobacterium Infections, Nontuberculous*/microbiology
Mycobacterium tuberculosis*
Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Humans ; Macrophages
Czasopismo naukowe
Tytuł:
The impact of Mycobacterium tuberculosis complex in the environment on one health approach.
Autorzy:
Zhang H; National Animal Tuberculosis Reference Laboratory, Division of Zoonoses Surveillance, China Animal Health and Epidemiology Center, Qingdao, China.
Liu M; National Animal Tuberculosis Reference Laboratory, Division of Zoonoses Surveillance, China Animal Health and Epidemiology Center, Qingdao, China.
Fan W; National Animal Tuberculosis Reference Laboratory, Division of Zoonoses Surveillance, China Animal Health and Epidemiology Center, Qingdao, China.
Sun S; National Animal Tuberculosis Reference Laboratory, Division of Zoonoses Surveillance, China Animal Health and Epidemiology Center, Qingdao, China.
Fan X; National Animal Tuberculosis Reference Laboratory, Division of Zoonoses Surveillance, China Animal Health and Epidemiology Center, Qingdao, China.
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Źródło:
Frontiers in public health [Front Public Health] 2022 Sep 07; Vol. 10, pp. 994745. Date of Electronic Publication: 2022 Sep 07 (Print Publication: 2022).
Typ publikacji:
Journal Article; Review
MeSH Terms:
Mycobacterium tuberculosis*
One Health*
Tuberculosis*/microbiology
Animals ; Dust ; Humans ; Soil ; Water
Czasopismo naukowe

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