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Wyszukujesz frazę ""Myeloid-Derived Suppressor Cells"" wg kryterium: Temat


Tytuł :
Metabolic reprogramming of myeloid-derived suppressor cells: An innovative approach confronting challenges.
Autorzy :
Li X; Bone Marrow Transplantation Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.; Institute of Hematology, Zhejiang University, Hangzhou, Zhejiang, China.; Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, Zhejiang, China.; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, Zhejiang, China.
Li Y; Bone Marrow Transplantation Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.; Institute of Hematology, Zhejiang University, Hangzhou, Zhejiang, China.; Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, Zhejiang, China.; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, Zhejiang, China.
Yu Q; Bone Marrow Transplantation Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.; Institute of Hematology, Zhejiang University, Hangzhou, Zhejiang, China.; Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, Zhejiang, China.; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, Zhejiang, China.
Qian P; Institute of Hematology, Zhejiang University, Hangzhou, Zhejiang, China.; Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, Zhejiang, China.; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, Zhejiang, China.
Huang H; Bone Marrow Transplantation Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.; Institute of Hematology, Zhejiang University, Hangzhou, Zhejiang, China.; Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, Zhejiang, China.; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, Zhejiang, China.
Lin Y; Bone Marrow Transplantation Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.; Institute of Hematology, Zhejiang University, Hangzhou, Zhejiang, China.; Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, Zhejiang, China.; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, Zhejiang, China.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2021 Aug; Vol. 110 (2), pp. 257-270. Date of Electronic Publication: 2021 Jun 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Energy Metabolism*
Immunomodulation*
Metabolic Networks and Pathways*
Myeloid-Derived Suppressor Cells/*immunology
Myeloid-Derived Suppressor Cells/*metabolism
Adenosine/metabolism ; Amino Acids/metabolism ; Biomarkers ; Cellular Microenvironment/immunology ; Disease Management ; Disease Susceptibility ; Extracellular Space/metabolism ; Glucose/metabolism ; Homeostasis ; Humans ; Lipid Metabolism ; Molecular Targeted Therapy ; Myeloid-Derived Suppressor Cells/drug effects
Czasopismo naukowe
Tytuł :
Chronic restraint stress promotes the mobilization and recruitment of myeloid-derived suppressor cells through β-adrenergic-activated CXCL5-CXCR2-Erk signaling cascades.
Autorzy :
Cao M; Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, China.
Huang W; Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, China.
Chen Y; Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, China.
Li G; Medical College, Tibet University, Lhasa, Tibet Autonomous Region, China.
Liu N; Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, China.
Wu Y; Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, China.
Wang G; Medical College, Tibet University, Lhasa, Tibet Autonomous Region, China.
Li Q; Medical College, Tibet University, Lhasa, Tibet Autonomous Region, China.
Kong D; Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, China.
Xue T; Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, China.
Yang N; Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, China.
Liu Y; Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, China.; Medical College, Tibet University, Lhasa, Tibet Autonomous Region, China.
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Źródło :
International journal of cancer [Int J Cancer] 2021 Jul 15; Vol. 149 (2), pp. 460-472. Date of Electronic Publication: 2021 Apr 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adrenergic beta-Antagonists/*administration & dosage
Carcinoma, Hepatocellular/*drug therapy
Liver Neoplasms/*drug therapy
Myeloid-Derived Suppressor Cells/*metabolism
Propranolol/*administration & dosage
Stress, Psychological/*complications
Adrenergic beta-Antagonists/pharmacology ; Animals ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Cell Line, Tumor ; Chemokine CXCL5 ; Gene Expression Regulation, Neoplastic/drug effects ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; MAP Kinase Signaling System/drug effects ; Male ; Mice ; Myeloid-Derived Suppressor Cells/drug effects ; Neoplasm Transplantation ; Propranolol/pharmacology ; Receptors, Interleukin-8B ; Spleen/immunology ; Stress, Psychological/etiology ; Stress, Psychological/metabolism
Czasopismo naukowe
Tytuł :
Immune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells.
Autorzy :
Vito A; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada.
Salem O; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada.
El-Sayes N; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada.
MacFawn IP; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Portillo AL; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada.
Milne K; Deeley Research Centre, BC Cancer, Victoria, BC, Canada.
Harrington D; Deeley Research Centre, BC Cancer, Victoria, BC, Canada.
Ashkar AA; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada.
Wan Y; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada.
Workenhe ST; Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.
Nelson BH; Deeley Research Centre, BC Cancer, Victoria, BC, Canada.; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada.; Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Bruno TC; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Mossman KL; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada. .; Department of Medicine, McMaster University, Hamilton, ON, Canada. .
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Źródło :
Communications biology [Commun Biol] 2021 Jul 12; Vol. 4 (1), pp. 859. Date of Electronic Publication: 2021 Jul 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
B-Lymphocytes/*drug effects
Immune Checkpoint Inhibitors/*therapeutic use
Immunotherapy/*methods
Lymphocytes, Tumor-Infiltrating/*drug effects
Myeloid-Derived Suppressor Cells/*drug effects
Triple Negative Breast Neoplasms/*therapy
Animals ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Cell Line, Tumor ; Chlorocebus aethiops ; Combined Modality Therapy ; Female ; Humans ; Immune Checkpoint Inhibitors/immunology ; Kaplan-Meier Estimate ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/metabolism ; Mice, Inbred C57BL ; Myeloid-Derived Suppressor Cells/immunology ; Myeloid-Derived Suppressor Cells/metabolism ; Oncolytic Virotherapy/methods ; Triple Negative Breast Neoplasms/immunology ; Triple Negative Breast Neoplasms/pathology ; Vero Cells
Czasopismo naukowe
Tytuł :
Targeting Myeloid-Derived Suppressor Cells to Enhance a Trans-Sialidase-Based Vaccine Against Trypanosoma cruzi .
Autorzy :
Gamba JC; Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina.
Roldán C; Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina.
Prochetto E; Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina.
Lupi G; Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina.
Bontempi I; Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina.; Facultad de Ciencias Médicas, Universidad Nacional del Litoral, Santa Fe, Argentina.
Poncini CV; Departamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
Vermeulen M; Laboratorio de Inmunología Oncológica, Instituto de Medicina Experimental (IMEX-CONICET), Academia Nacional de Medicina, Buenos Aires, Argentina.
Pérez AR; IDICER-CONICET and Instituto de Inmunología, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Santa Fe, Argentina.
Marcipar I; Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina.; Facultad de Ciencias Médicas, Universidad Nacional del Litoral, Santa Fe, Argentina.
Cabrera G; Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina.; Facultad de Ciencias Médicas, Universidad Nacional del Litoral, Santa Fe, Argentina.
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Źródło :
Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2021 Jul 06; Vol. 11, pp. 671104. Date of Electronic Publication: 2021 Jul 06 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chagas Disease*/prevention & control
Myeloid-Derived Suppressor Cells*
Protozoan Vaccines*
Trypanosoma cruzi*
Animals ; Glycoproteins ; Mice ; Neuraminidase
Czasopismo naukowe
Tytuł :
Granulocytic and Monocytic Myeloid-Derived Suppressor Cells are Functionally and Prognostically Different in Patients with Chronic Myeloid Leukemia.
Autorzy :
Ahn A; Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Park CJ; Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.
Kim MS; Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.
Cho YU; Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.
Jang S; Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.
Bae MH; Department of Laboratory Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.
Lee JH; Department of Internal Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.
Lee JH; Department of Internal Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.
Koh KN; Department of Pediatrics, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.
Im HJ; Department of Pediatrics, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.
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Źródło :
Annals of laboratory medicine [Ann Lab Med] 2021 Sep 01; Vol. 41 (5), pp. 479-484.
Typ publikacji :
Journal Article
MeSH Terms :
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/diagnosis
Myeloid-Derived Suppressor Cells*/immunology
Granulocytes ; HLA-DR Antigens ; Humans ; Monocytes
Czasopismo naukowe
Tytuł :
[Exosomes derived from PMN-MDSCs preconditioned by hypoxia attenuate arthropathy of collagen-induced arthritis mice].
Autorzy :
Chu X; Department of Laboratory Medicine, Nanjing Second Hospital, Nanjing University of Chinese Medicine, Nanjing 210009, China.
Chen L; Department of Laboratory Medicine, Yifu Hospital, Nanjing Medical University, Nanjing 211100, China.
Zhang Y; Department of Laboratory Medicine, Nanjing Second Hospital, Nanjing University of Chinese Medicine, Nanjing 210009, China . *Corresponding author, E-mail: .
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Źródło :
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology [Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi] 2021 Aug; Vol. 37 (8), pp. 728-735.
Typ publikacji :
Journal Article
MeSH Terms :
Arthritis, Experimental*
Exosomes*
Myeloid-Derived Suppressor Cells*
Animals ; Cattle ; Cell Proliferation ; Hypoxia ; Mice
Czasopismo naukowe
Tytuł :
MicroRNA-150 inhibits myeloid-derived suppressor cells proliferation and function through negative regulation of ARG-1 in sepsis.
Autorzy :
Liu Q; Department of Traumatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Division of Plastic Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Wang Y; Department of Traumatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zheng Q; Department of Traumatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Dong X; Department of Traumatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xie Z; Department of Traumatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Panayi A; Division of Plastic Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Bai X; Department of Traumatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: .
Li Z; Department of Traumatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Aug 01; Vol. 278, pp. 119626. Date of Electronic Publication: 2021 May 15.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Proliferation*
Arginase/*metabolism
MicroRNAs/*genetics
Myeloid-Derived Suppressor Cells/*immunology
Sepsis/*pathology
Adolescent ; Adult ; Aged ; Animals ; Arginase/genetics ; Case-Control Studies ; Cytokines/metabolism ; Female ; Gene Expression Regulation ; Humans ; Immune Tolerance/immunology ; Male ; Mice ; Mice, Inbred C57BL ; Middle Aged ; Myeloid-Derived Suppressor Cells/cytology ; Sepsis/genetics ; Sepsis/immunology ; Sepsis/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
Circulating CD15 PMN-MDSCs are a potential biomarker for the early diagnosis of non-small-cell lung cancer.
Autorzy :
Tian X; Department of Laboratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu, China.
Wang T; Department of Laboratory Medicine, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Zheng Q; Department of Laboratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu, China.
Tao Y; Department of Laboratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu, China.
Dai L; Department of Laboratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu, China.
Shen H; Department of Laboratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu, China.
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Źródło :
International journal of clinical practice [Int J Clin Pract] 2021 Aug; Vol. 75 (8), pp. e14317. Date of Electronic Publication: 2021 May 17.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Non-Small-Cell Lung*/diagnosis
Lung Neoplasms*/diagnosis
Myeloid-Derived Suppressor Cells*
Antigens, Neoplasm ; Biomarkers ; Early Detection of Cancer ; Humans ; Keratin-19 ; Neoplasm Recurrence, Local ; Scavenger Receptors, Class E
Czasopismo naukowe
Tytuł :
[Effect of gMDSCs on natural killer cell functionality in chronic hepatitis C patients treated with direct-acting antiviral agents].
Autorzy :
Shi JJ; Key Medical Laboratory of Stem Cell Transformation and Application,the First People's Hospital of Zhengzhou, Zhengzhou 450000, China.
Zhou WJ; Department of Infectious Diseases, Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China.
Lu C; Key Medical Laboratory of Stem Cell Transformation and Application,the First People's Hospital of Zhengzhou, Zhengzhou 450000, China.
Jia XY; Department of Infectious Diseases, Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China.
Chang WX; Department of Infectious Diseases, Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China.
Zhang JY; Department of Infectious Diseases, Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China.
Li YY; Department of Infectious Diseases, Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China.
Mu XL; Key Medical Laboratory of Stem Cell Transformation and Application,the First People's Hospital of Zhengzhou, Zhengzhou 450000, China.
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Źródło :
Zhonghua yi xue za zhi [Zhonghua Yi Xue Za Zhi] 2021 Jul 20; Vol. 101 (27), pp. 2133-2139.
Typ publikacji :
Journal Article
MeSH Terms :
Hepatitis C, Chronic*/drug therapy
Myeloid-Derived Suppressor Cells*
Adult ; Aged ; Antiviral Agents/therapeutic use ; Female ; Flow Cytometry ; Humans ; Killer Cells, Natural ; Male ; Middle Aged ; Young Adult
Czasopismo naukowe
Tytuł :
Severe COVID-19 Is Characterized by an Impaired Type I Interferon Response and Elevated Levels of Arginase Producing Granulocytic Myeloid Derived Suppressor Cells.
Autorzy :
Dean MJ; Louisiana State University Cancer Center, New Orleans, LA, United States.
Ochoa JB; Department of Surgery, Ochsner Medical Center, New Orleans, LA, United States.
Sanchez-Pino MD; Louisiana State University Cancer Center, New Orleans, LA, United States.; Department of Genetics, LSU Health, New Orleans, LA, United States.
Zabaleta J; Louisiana State University Cancer Center, New Orleans, LA, United States.; Department of Pediatrics, LSU Health, New Orleans, LA, United States.
Garai J; Louisiana State University Cancer Center, New Orleans, LA, United States.
Del Valle L; Louisiana State University Cancer Center, New Orleans, LA, United States.; Department of Pathology LSU Health, New Orleans, LA, United States.
Wyczechowska D; Louisiana State University Cancer Center, New Orleans, LA, United States.
Baiamonte LB; Tissue Biorepository, Ochsner Medical Center, New Orleans, LA, United States.
Philbrook P; Louisiana State University Cancer Center, New Orleans, LA, United States.; Department of Genetics, LSU Health, New Orleans, LA, United States.
Majumder R; Department of Biochemistry, LSU Health, New Orleans, LA, United States.
Vander Heide RS; Department of Pathology LSU Health, New Orleans, LA, United States.
Dunkenberger L; Louisiana State University Cancer Center, New Orleans, LA, United States.
Thylur RP; Louisiana State University Cancer Center, New Orleans, LA, United States.
Nossaman B; Department of Surgery, Ochsner Medical Center, New Orleans, LA, United States.
Roberts WM; Department of Internal Medicine, Ochsner Medical Center, New Orleans, LA, United States.
Chapple AG; Louisiana State University Cancer Center, New Orleans, LA, United States.; School of Public Health, LSU Health, New Orleans, LA, United States.
Wu J; Department of Genetics, LSU Health, New Orleans, LA, United States.
Hicks C; Department of Genetics, LSU Health, New Orleans, LA, United States.
Collins J; Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, MD, United States.
Luke B; Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, MD, United States.
Johnson R; Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, MD, United States.
Koul HK; Louisiana State University Cancer Center, New Orleans, LA, United States.; Department of Biochemistry, LSU Health, New Orleans, LA, United States.
Rees CA; Division of Emergency Medicine, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA, United States.
Morris CR; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, Children's Healthcare of Atlanta, Atlanta, GA, United States.
Garcia-Diaz J; Tissue Biorepository, Ochsner Medical Center, New Orleans, LA, United States.
Ochoa AC; Louisiana State University Cancer Center, New Orleans, LA, United States.; Department of Pediatrics, LSU Health, New Orleans, LA, United States.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Jul 14; Vol. 12, pp. 695972. Date of Electronic Publication: 2021 Jul 14 (Print Publication: 2021).
Typ publikacji :
Journal Article; Observational Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19/*immunology
Granulocytes/*immunology
Myeloid-Derived Suppressor Cells/*immunology
SARS-CoV-2/*immunology
Adult ; Aged ; Aged, 80 and over ; Antiviral Agents/administration & dosage ; Arginase/antagonists & inhibitors ; Arginase/metabolism ; Arginine/administration & dosage ; Arginine/blood ; Arginine/metabolism ; Asymptomatic Infections ; COVID-19/blood ; COVID-19/diagnosis ; COVID-19/drug therapy ; Case-Control Studies ; Drug Therapy, Combination/methods ; Enzyme Inhibitors/administration & dosage ; Female ; Granulocytes/metabolism ; Healthy Volunteers ; Humans ; Interferon Type I/metabolism ; Male ; Middle Aged ; Myeloid-Derived Suppressor Cells/metabolism ; Severity of Illness Index ; Signal Transduction/immunology ; T-Lymphocytes/immunology
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Redox-responsive nanoassembly restrained myeloid-derived suppressor cells recruitment through autophagy-involved lactate dehydrogenase A silencing for enhanced cancer immunochemotherapy.
Autorzy :
Xia C; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Li M; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Ran G; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Wang X; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Lu Z; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Li T; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Tang X; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Zhang Z; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
He Q; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China. Electronic address: .
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Źródło :
Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2021 Jul 10; Vol. 335, pp. 557-574. Date of Electronic Publication: 2021 May 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Myeloid-Derived Suppressor Cells*
Neoplasms*
Autophagy ; Humans ; Lactate Dehydrogenase 5 ; Oxidation-Reduction
Czasopismo naukowe
Tytuł :
Expression of a constitutively active p38α mutant in mice causes early death, anemia, and accumulation of immunosuppressive cells.
Autorzy :
Darlyuk-Saadon I; CREATE-NUS-HUJ, Molecular Mechanisms of Inflammatory Diseases Program, National University of Singapore, Singapore.; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Heng CKM; CREATE-NUS-HUJ, Molecular Mechanisms of Inflammatory Diseases Program, National University of Singapore, Singapore.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, Singapore.
Bai C; CREATE-NUS-HUJ, Molecular Mechanisms of Inflammatory Diseases Program, National University of Singapore, Singapore.; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Gilad N; CREATE-NUS-HUJ, Molecular Mechanisms of Inflammatory Diseases Program, National University of Singapore, Singapore.; Department of Biological Chemistry, The Institute of Life Science, The Hebrew University of Jerusalem, Israel.
Yu WP; Animal Gene Editing Laboratory (AGEL), Biological Resource Centre, Agency for Science, Technology and Research (A*STAR), Singapore.; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore.
Meng Huang Mok M; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Wong WSF; CREATE-NUS-HUJ, Molecular Mechanisms of Inflammatory Diseases Program, National University of Singapore, Singapore.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, Singapore.; Immunology Programme, Life Science Institute, National University of Singapore, Singapore.
Engelberg D; CREATE-NUS-HUJ, Molecular Mechanisms of Inflammatory Diseases Program, National University of Singapore, Singapore.; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Biological Chemistry, The Institute of Life Science, The Hebrew University of Jerusalem, Israel.
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Źródło :
The FEBS journal [FEBS J] 2021 Jul; Vol. 288 (13), pp. 3978-3999. Date of Electronic Publication: 2021 Jan 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Enzymologic*
Mutation*
Anemia/*genetics
Macrophages/*metabolism
Mitogen-Activated Protein Kinase 14/*genetics
Myeloid-Derived Suppressor Cells/*metabolism
Anemia/enzymology ; Animals ; Body Weight/genetics ; Cytokines/blood ; Cytokines/metabolism ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Macrophages/classification ; Macrophages/immunology ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Mitogen-Activated Protein Kinase 14/metabolism ; Myeloid-Derived Suppressor Cells/immunology ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Targeting Myeloid-Derived Suppressor Cells for Premetastatic Niche Disruption After Tumor Resection.
Autorzy :
Tang F; Laboratory of Aging Research and Cancer Drug Target, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.; Department of Orthopeadics, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
Tie Y; Department of Oncology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, People's Republic of China.
Hong W; Laboratory of Aging Research and Cancer Drug Target, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
Wei Y; Laboratory of Aging Research and Cancer Drug Target, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
Tu C; Department of Orthopeadics, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. .
Wei X; Laboratory of Aging Research and Cancer Drug Target, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. .
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Źródło :
Annals of surgical oncology [Ann Surg Oncol] 2021 Jul; Vol. 28 (7), pp. 4030-4048. Date of Electronic Publication: 2020 Nov 30.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Agents*
Myeloid-Derived Suppressor Cells*
Neoplastic Cells, Circulating*
Humans ; Lung ; Neoplasm Recurrence, Local
Czasopismo naukowe
Tytuł :
[Progress in immune regulation involving exosomes in hypoxic tumor microenvironment].
Autorzy :
Wang L; Sichuan Cancer Hospital & Sichuan Key Laboratory of Radiation Oncology, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China.
Zhu G; Sichuan Cancer Hospital & Sichuan Key Laboratory of Radiation Oncology, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041; West China Hospital of Stomatology, Sichuan University, National Clinical Research Center for Oral Diseases, State Key Laboratory of Oral Disease, Chengdu 610041, China. *Corresponding authors, E-mail: .
Li L; Sichuan Cancer Hospital & Sichuan Key Laboratory of Radiation Oncology, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China. *Corresponding authors, E-mail: .
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Źródło :
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology [Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi] 2021 Jul; Vol. 37 (7), pp. 651-656.
Typ publikacji :
Journal Article
MeSH Terms :
Exosomes*
Myeloid-Derived Suppressor Cells*
Cell Line, Tumor ; Humans ; Hypoxia ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
GMI, an Immunomodulatory Peptide from Ganoderma microsporum , Restrains Periprosthetic Joint Infections via Modulating the Functions of Myeloid-Derived Suppressor Cells and Effector T Cells.
Autorzy :
Peng KT; Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Puzi 61363, Taiwan.; College of Medicine, Chang Gung University, Taoyuan 33303, Taiwan.
Chen JL; Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Puzi 61363, Taiwan.
Kuo LT; Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Puzi 61363, Taiwan.; College of Medicine, Chang Gung University, Taoyuan 33303, Taiwan.
Yu PA; Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Puzi 61363, Taiwan.
Hsu WH; Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Puzi 61363, Taiwan.; College of Medicine, Chang Gung University, Taoyuan 33303, Taiwan.
Lee CW; Division of Basic Medical Sciences and Recurrent Diseases, Health Promotion Research Center, Department of Nursing, Chang Gung University of Science and Technology, Puzi 61363, Taiwan.; Research Center for Industry of Human Ecology, Research Center for Chinese Herbal Medicine, Chang Gung University of Science and Technology, Taoyuan 33303, Taiwan.; Department of Rehabilitation, Chang Gung Memorial Hospital, Puzi 61363, Taiwan.
Chang PJ; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang-Gung University, Taoyuan 33302, Taiwan.; Department of Nephrology, Chang-Gung Memorial Hospital, Chiayi 61363, Taiwan.
Huang TY; College of Medicine, Chang Gung University, Taoyuan 33303, Taiwan.; Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital, Chiayi 61363, Taiwan.; Department of Nursing, Chiayi Campus, Chang Gung University of Science and Technology, Chiayi 61363, Taiwan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 25; Vol. 22 (13). Date of Electronic Publication: 2021 Jun 25.
Typ publikacji :
Journal Article
MeSH Terms :
Ganoderma/*chemistry
Immunomodulation/*drug effects
Myeloid-Derived Suppressor Cells/*drug effects
Myeloid-Derived Suppressor Cells/*immunology
Peptides/*pharmacology
T-Lymphocytes/*drug effects
T-Lymphocytes/*immunology
Animals ; Arthritis, Infectious/diagnosis ; Arthritis, Infectious/drug therapy ; Arthritis, Infectious/etiology ; Arthritis, Infectious/metabolism ; Biofilms/drug effects ; Biomarkers ; Biopsy ; Cytokines/metabolism ; Disease Models, Animal ; Disease Susceptibility ; Male ; Mice ; Myeloid-Derived Suppressor Cells/metabolism ; Peptides/chemistry ; Prosthesis-Related Infections/diagnosis ; Prosthesis-Related Infections/drug therapy ; Prosthesis-Related Infections/etiology ; Prosthesis-Related Infections/metabolism ; Reactive Oxygen Species ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/physiology ; T-Lymphocytes/metabolism
Czasopismo naukowe
Tytuł :
[Roles of Myeloid-derived Suppressor Cells in Breast Cancer Metastasis].
Autorzy :
Peng XY; The First Clinical College of Zhejiang Chinese Medical University,Hangzhou 310053,China.
Li Y; Department of Oncology,the First Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou 310006,China.
Xu ZL; The First Clinical College of Zhejiang Chinese Medical University,Hangzhou 310053,China.
Guo Y; Department of Oncology,the First Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou 310006,China.
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Źródło :
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae [Zhongguo Yi Xue Ke Xue Yuan Xue Bao] 2021 Jun 30; Vol. 43 (3), pp. 445-451.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Breast Neoplasms*
Lung Neoplasms*
Myeloid-Derived Suppressor Cells*
Female ; Humans ; Neoplasm Metastasis ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Comments on the ambiguity of selected surface markers, signaling pathways and omics profiles hampering the identification of myeloid-derived suppressor cells.
Autorzy :
Lutz MB; Institute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany. Electronic address: .
Eckert IN; Institute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany.
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Źródło :
Cellular immunology [Cell Immunol] 2021 Jun; Vol. 364, pp. 104347. Date of Electronic Publication: 2021 Mar 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biomarkers/*metabolism
Gene Expression Profiling/*methods
Myeloid-Derived Suppressor Cells/*immunology
Proteomics/*methods
Signal Transduction/*immunology
Animals ; B7-H1 Antigen/genetics ; B7-H1 Antigen/immunology ; B7-H1 Antigen/metabolism ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19/virology ; Cells, Cultured ; Humans ; Mice ; Myeloid-Derived Suppressor Cells/metabolism ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/metabolism ; Programmed Cell Death 1 Receptor/genetics ; Programmed Cell Death 1 Receptor/immunology ; Programmed Cell Death 1 Receptor/metabolism ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/physiology ; Signal Transduction/genetics ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism
Czasopismo naukowe
Tytuł :
Obesity-Associated Myeloid Immunosuppressive Cells, Key Players in Cancer Risk and Response to Immunotherapy.
Autorzy :
Sanchez-Pino MD; Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center School of Medicine, New Orleans, Louisiana, USA.; Department of Genetics, Louisiana State University Health Sciences Center School of Medicine, New Orleans, Louisiana, USA.
Gilmore LA; University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Ochoa AC; Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center School of Medicine, New Orleans, Louisiana, USA.; Department of Pediatrics, Louisiana State University Health Sciences Center School of Medicine, New Orleans, Louisiana, USA.
Brown JC; Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center School of Medicine, New Orleans, Louisiana, USA.; Department of Genetics, Louisiana State University Health Sciences Center School of Medicine, New Orleans, Louisiana, USA.; LSU Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
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Źródło :
Obesity (Silver Spring, Md.) [Obesity (Silver Spring)] 2021 Jun; Vol. 29 (6), pp. 944-953. Date of Electronic Publication: 2021 Feb 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Immunotherapy*/methods
Myeloid-Derived Suppressor Cells/*physiology
Neoplasms/*etiology
Obesity/*immunology
Adipose Tissue/metabolism ; Animals ; Carcinogenesis/immunology ; Carcinogenesis/metabolism ; Carcinogenesis/pathology ; Humans ; Inflammation Mediators/metabolism ; Leptin/metabolism ; Macrophages/metabolism ; Myeloid-Derived Suppressor Cells/immunology ; Myeloid-Derived Suppressor Cells/metabolism ; Myeloid-Derived Suppressor Cells/pathology ; Neoplasm Metastasis ; Neoplasms/immunology ; Neoplasms/pathology ; Neoplasms/prevention & control ; Obesity/complications ; Obesity/metabolism ; Obesity/therapy ; Risk Factors ; Tumor Microenvironment/immunology
Czasopismo naukowe
Tytuł :
Role of myeloid-derived suppressor cells in metastasis.
Autorzy :
Cole K; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Pravoverov K; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Talmadge JE; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, 68198, USA. .; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198-5950, USA. .; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 68198-6495, USA. .
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Źródło :
Cancer metastasis reviews [Cancer Metastasis Rev] 2021 Jun; Vol. 40 (2), pp. 391-411. Date of Electronic Publication: 2021 Jan 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Myeloid-Derived Suppressor Cells/*pathology
Neoplasms/*pathology
Animals ; Humans ; Myeloid-Derived Suppressor Cells/immunology ; Neoplasm Metastasis ; Neoplasms/immunology ; Neoplasms/therapy ; Translational Medical Research
Czasopismo naukowe
Tytuł :
Human splenic myeloid derived suppressor cells: Phenotypic and clustering analysis.
Autorzy :
Cole KE; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, United States.
Ly QP; Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198-4990, United States.
Hollingsworth MA; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198-5950, United States.
Cox JL; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, United States.
Padussis JC; Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198-4990, United States.
Foster JM; Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198-4990, United States.
Vargas LM; Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198-4990, United States.
Talmadge JE; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, United States; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, United States. Electronic address: .
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Źródło :
Cellular immunology [Cell Immunol] 2021 May; Vol. 363, pp. 104317. Date of Electronic Publication: 2021 Mar 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Myeloid-Derived Suppressor Cells/*metabolism
Spleen/*immunology
Adult ; Aged ; Arginase/metabolism ; B7-H1 Antigen/metabolism ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cluster Analysis ; Female ; Flow Cytometry/methods ; Gastrointestinal Neoplasms/immunology ; HLA-DR Antigens/metabolism ; Humans ; Male ; Middle Aged ; Myeloid-Derived Suppressor Cells/cytology ; Myeloid-Derived Suppressor Cells/immunology ; Neoplasms/immunology ; Programmed Cell Death 1 Receptor/metabolism ; Scavenger Receptors, Class E/metabolism ; Spleen/pathology
Czasopismo naukowe

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