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Tytuł:
Dimensionality reduction methods for extracting functional networks from large-scale CRISPR screens.
Autorzy:
Hassan AZ; Department of Computer Science and Engineering, University of Minnesota - Twin Cities, Minneapolis, MN, USA.
Ward HN; Bioinformatics and Computational Biology Graduate Program, University of Minnesota - Twin Cities, Minneapolis, MN, USA.
Rahman M; Department of Computer Science and Engineering, University of Minnesota - Twin Cities, Minneapolis, MN, USA.
Billmann M; Department of Computer Science and Engineering, University of Minnesota - Twin Cities, Minneapolis, MN, USA.; Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.
Lee Y; Bioinformatics and Computational Biology Graduate Program, University of Minnesota - Twin Cities, Minneapolis, MN, USA.
Myers CL; Department of Computer Science and Engineering, University of Minnesota - Twin Cities, Minneapolis, MN, USA.; Bioinformatics and Computational Biology Graduate Program, University of Minnesota - Twin Cities, Minneapolis, MN, USA.
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Źródło:
Molecular systems biology [Mol Syst Biol] 2023 Nov 09; Vol. 19 (11), pp. e11657. Date of Electronic Publication: 2023 Sep 26.
Typ publikacji:
Journal Article
MeSH Terms:
Oncogenes*
Gene Regulatory Networks*
Humans ; Cell Line, Tumor ; CRISPR-Cas Systems/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Systems-level transcriptional regulation of Caenorhabditis elegans metabolism.
Autorzy:
Nanda S; Department of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Jacques MA; Department of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Wang W; Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN, USA.
Myers CL; Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN, USA.
Yilmaz LS; Department of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Walhout AJ; Department of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
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Źródło:
Molecular systems biology [Mol Syst Biol] 2023 May 09; Vol. 19 (5), pp. e11443. Date of Electronic Publication: 2023 Mar 21.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Caenorhabditis elegans*/genetics
Caenorhabditis elegans*/metabolism
Caenorhabditis elegans Proteins*/genetics
Caenorhabditis elegans Proteins*/metabolism
Animals ; Humans ; Gene Expression Regulation ; Software
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Repression of essential cell cycle genes increases cellular fitness.
Autorzy:
Conti MM; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America.
Ghizzoni JM; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America.
Gil-Bona A; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America.
Wang W; Department of Computer Science and Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America.
Costanzo M; Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Li R; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America.
Flynn MJ; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America.
Zhu LJ; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America.; Program in Bioinformatics and Integrative Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America.; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America.
Myers CL; Department of Computer Science and Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America.
Boone C; Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Andrews BJ; Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Benanti JA; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America.
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Źródło:
PLoS genetics [PLoS Genet] 2022 Aug 29; Vol. 18 (8), pp. e1010349. Date of Electronic Publication: 2022 Aug 29 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Genes, cdc*
Saccharomyces cerevisiae Proteins*/genetics
Saccharomyces cerevisiae Proteins*/metabolism
Cell Cycle/genetics ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cyclin-Dependent Kinases/genetics ; Cyclin-Dependent Kinases/metabolism ; Mitosis/genetics ; Phosphorylation ; Saccharomyces cerevisiae/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Environmental robustness of the global yeast genetic interaction network.
Autorzy:
Costanzo M; The Donnelly Centre, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada.
Hou J; The Donnelly Centre, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada.
Messier V; The Donnelly Centre, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada.
Nelson J; Department of Computer Science and Engineering, University of Minnesota-Twin Cities, 200 Union Street, Minneapolis, MN 55455, USA.; Program in Biomedical Informatics and Computational Biology, University of Minnesota-Twin Cities, 200 Union Street, Minneapolis, MN 55455, USA.
Rahman M; Department of Computer Science and Engineering, University of Minnesota-Twin Cities, 200 Union Street, Minneapolis, MN 55455, USA.; Program in Biomedical Informatics and Computational Biology, University of Minnesota-Twin Cities, 200 Union Street, Minneapolis, MN 55455, USA.
VanderSluis B; Department of Computer Science and Engineering, University of Minnesota-Twin Cities, 200 Union Street, Minneapolis, MN 55455, USA.
Wang W; Department of Computer Science and Engineering, University of Minnesota-Twin Cities, 200 Union Street, Minneapolis, MN 55455, USA.
Pons C; Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute for Science and Technology, Barcelona, Spain.
Ross C; The Donnelly Centre, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada.
Ušaj M; The Donnelly Centre, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada.
San Luis BJ; The Donnelly Centre, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada.
Shuteriqi E; The Donnelly Centre, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada.
Koch EN; Department of Computer Science and Engineering, University of Minnesota-Twin Cities, 200 Union Street, Minneapolis, MN 55455, USA.
Aloy P; Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute for Science and Technology, Barcelona, Spain.; Institució Catalana de Recerca I Estudis Avaçats (ICREA), Barcelona, Spain.
Myers CL; Department of Computer Science and Engineering, University of Minnesota-Twin Cities, 200 Union Street, Minneapolis, MN 55455, USA. .; Program in Biomedical Informatics and Computational Biology, University of Minnesota-Twin Cities, 200 Union Street, Minneapolis, MN 55455, USA.
Boone C; The Donnelly Centre, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada. .; Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada.; RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan.
Andrews B; The Donnelly Centre, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada. .; Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada.
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Źródło:
Science (New York, N.Y.) [Science] 2021 May 07; Vol. 372 (6542).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Regulatory Networks*
Gene-Environment Interaction*
Saccharomyces cerevisiae/*genetics
Saccharomyces cerevisiae Proteins/*genetics
Alleles ; Genetic Fitness ; Mutation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A method for benchmarking genetic screens reveals a predominant mitochondrial bias.
Autorzy:
Rahman M; Department of Computer Science and Engineering, University of Minnesota - Twin Cities, Minneapolis, MN, USA.
Billmann M; Department of Computer Science and Engineering, University of Minnesota - Twin Cities, Minneapolis, MN, USA.
Costanzo M; Donnelly Centre, University of Toronto, Toronto, ON, Canada.
Aregger M; Donnelly Centre, University of Toronto, Toronto, ON, Canada.
Tong AHY; Donnelly Centre, University of Toronto, Toronto, ON, Canada.
Chan K; Donnelly Centre, University of Toronto, Toronto, ON, Canada.
Ward HN; Bioinformatics and Computational Biology Graduate Program, University of Minnesota - Twin Cities, Minneapolis, MN, USA.
Brown KR; Donnelly Centre, University of Toronto, Toronto, ON, Canada.
Andrews BJ; Donnelly Centre, University of Toronto, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
Boone C; Donnelly Centre, University of Toronto, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
Moffat J; Donnelly Centre, University of Toronto, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
Myers CL; Department of Computer Science and Engineering, University of Minnesota - Twin Cities, Minneapolis, MN, USA.; Bioinformatics and Computational Biology Graduate Program, University of Minnesota - Twin Cities, Minneapolis, MN, USA.
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Źródło:
Molecular systems biology [Mol Syst Biol] 2021 May; Vol. 17 (5), pp. e10013.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Gene Regulatory Networks*
Genetic Testing/*methods
Mitochondria/*genetics
Systems Biology/*methods
Algorithms ; Benchmarking ; Bias ; CRISPR-Cas Systems ; Cell Line ; HEK293 Cells ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Systematic analysis of bypass suppression of essential genes.
Autorzy:
van Leeuwen J; Center for Integrative Genomics, Bâtiment Génopode, University of Lausanne, Lausanne, Switzerland.; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.
Pons C; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute for Science and Technology, Barcelona, Spain.
Tan G; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.
Wang JZ; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
Hou J; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.
Weile J; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.
Gebbia M; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.
Liang W; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.
Shuteriqi E; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.
Li Z; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.
Lopes M; Center for Integrative Genomics, Bâtiment Génopode, University of Lausanne, Lausanne, Switzerland.
Ušaj M; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.
Dos Santos Lopes A; Center for Integrative Genomics, Bâtiment Génopode, University of Lausanne, Lausanne, Switzerland.
van Lieshout N; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.
Myers CL; Department of Computer Science and Engineering, University of Minnesota-Twin Cities, Minneapolis, MN, USA.
Roth FP; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.; Department of Computer Science, University of Toronto, Toronto, ON, Canada.
Aloy P; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute for Science and Technology, Barcelona, Spain.; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
Andrews BJ; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
Boone C; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
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Źródło:
Molecular systems biology [Mol Syst Biol] 2020 Sep; Vol. 16 (9), pp. e9828.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Genes, Essential*
Genes, Fungal*
Suppression, Genetic*
Saccharomyces cerevisiae/*genetics
Aneuploidy ; Evolution, Molecular ; Gene Deletion ; Gene Duplication ; Gene Regulatory Networks ; Genes, Suppressor ; Multiprotein Complexes/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Exploring whole-genome duplicate gene retention with complex genetic interaction analysis.
Autorzy:
Kuzmin E; Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada.
VanderSluis B; Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
Nguyen Ba AN; Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada.; Center for Analysis of Evolution and Function, University of Toronto, Toronto, Ontario, Canada.
Wang W; Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
Koch EN; Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
Usaj M; Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada.
Khmelinskii A; Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany.
Usaj MM; Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada.
van Leeuwen J; Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada.
Kraus O; Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada.
Tresenrider A; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.
Pryszlak M; Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada.
Hu MC; Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada.
Varriano B; Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada.
Costanzo M; Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada.
Knop M; Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany.; Cell Morphogenesis and Signal Transduction, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Moses A; Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada.; Center for Analysis of Evolution and Function, University of Toronto, Toronto, Ontario, Canada.; Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada.
Myers CL; Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN 55455, USA. .
Andrews BJ; Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada. .; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada.
Boone C; Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada. .; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada.
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Źródło:
Science (New York, N.Y.) [Science] 2020 Jun 26; Vol. 368 (6498).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Duplication*
Genes, Duplicate*
Genome, Fungal*
Protein Interaction Maps/*genetics
Saccharomyces cerevisiae/*genetics
Saccharomyces cerevisiae Proteins/*genetics
Gene Deletion ; Gene Regulatory Networks ; Genetic Techniques ; Membrane Proteins/genetics ; Peroxins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Dbf4-Dependent Kinase (DDK)-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A in Saccharomyces cerevisiae .
Autorzy:
Eisenstatt JR; Genetics Branch, Center for Cancer Research, National Cancer Institute.
Boeckmann L; Genetics Branch, Center for Cancer Research, National Cancer Institute.
Au WC; Genetics Branch, Center for Cancer Research, National Cancer Institute.
Garcia V; Genetics Branch, Center for Cancer Research, National Cancer Institute.
Bursch L; Genetics Branch, Center for Cancer Research, National Cancer Institute.
Ocampo J; Division of Developmental Biology, Eunice Kennedy Shriver National Institute for Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20894.
Costanzo M; Department of Molecular Genetics.; Donnelly Centre for Cellular and Biomolecular Research, Toronto, Ontario M5S 3E1, Canada.
Weinreich M; Van Andel Research Institute, 333 Bostwick Ave NE, Grand Rapids, MI 49503.
Sclafani RA; Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado 80045.
Baryshnikova A; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544.
Myers CL; Department of Computer Science and Engineering, University of Minnesota-Twin Cities, Minneapolis, Minnesota 55455, and.
Boone C; Department of Molecular Genetics.; Donnelly Centre for Cellular and Biomolecular Research, Toronto, Ontario M5S 3E1, Canada.
Clark DJ; Division of Developmental Biology, Eunice Kennedy Shriver National Institute for Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20894.
Baker R; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts 01655.
Basrai MA; Genetics Branch, Center for Cancer Research, National Cancer Institute, .
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Źródło:
G3 (Bethesda, Md.) [G3 (Bethesda)] 2020 Jun 01; Vol. 10 (6), pp. 2057-2068. Date of Electronic Publication: 2020 Jun 01.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Saccharomyces cerevisiae*/genetics
Saccharomyces cerevisiae*/metabolism
Saccharomyces cerevisiae Proteins*/genetics
Saccharomyces cerevisiae Proteins*/metabolism
Cell Cycle Proteins/genetics ; Centromere/metabolism ; Centromere Protein A ; Chromosomal Proteins, Non-Histone/genetics ; Chromosomal Proteins, Non-Histone/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Humans ; Protein Serine-Threonine Kinases ; Proteolysis ; Ubiquitination
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Predicting bioprocess targets of chemical compounds through integration of chemical-genetic and genetic interactions.
Autorzy:
Simpkins SW; University of Minnesota-Twin Cities, Bioinformatics and Computational Biology Graduate Program, Minneapolis, Minnesota, United States of America.
Nelson J; University of Minnesota-Twin Cities, Bioinformatics and Computational Biology Graduate Program, Minneapolis, Minnesota, United States of America.
Deshpande R; University of Minnesota-Twin Cities, Department of Computer Science and Engineering, Minneapolis, Minnesota, United States of America.
Li SC; RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan.
Piotrowski JS; RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan.
Wilson EH; University of Minnesota-Twin Cities, Department of Computer Science and Engineering, Minneapolis, Minnesota, United States of America.
Gebre AA; University of Tokyo, Department of Integrated Biosciences, Graduate School of Frontier Sciences, Kashiwa, Chiba, Japan.
Safizadeh H; University of Minnesota-Twin Cities, Department of Computer Science and Engineering, Minneapolis, Minnesota, United States of America.; University of Minnesota, Department of Electrical and Computer Engineering, Minneapolis, Minnesota, United States of America.
Okamoto R; RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan.
Yoshimura M; RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan.
Costanzo M; University of Toronto, Donnelly Centre, Toronto, Ontario, Canada.
Yashiroda Y; RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan.
Ohya Y; University of Tokyo, Department of Integrated Biosciences, Graduate School of Frontier Sciences, Kashiwa, Chiba, Japan.
Osada H; RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan.
Yoshida M; RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan.
Boone C; RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan.; University of Toronto, Donnelly Centre, Toronto, Ontario, Canada.
Myers CL; University of Minnesota-Twin Cities, Bioinformatics and Computational Biology Graduate Program, Minneapolis, Minnesota, United States of America.; University of Minnesota-Twin Cities, Department of Computer Science and Engineering, Minneapolis, Minnesota, United States of America.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2018 Oct 30; Vol. 14 (10), pp. e1006532. Date of Electronic Publication: 2018 Oct 30 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Cell Cycle*/drug effects
Cell Cycle*/genetics
Gene Regulatory Networks*/drug effects
Gene Regulatory Networks*/genetics
Small Molecule Libraries*
Drug Discovery/*methods
Systems Biology/*methods
Colchicine/pharmacology ; Protein Multimerization/drug effects ; Reproducibility of Results ; Tubulin/drug effects ; Tubulin/metabolism ; Tubulin Modulators/pharmacology ; Yeasts/drug effects ; Yeasts/genetics ; Yeasts/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Systematic analysis of complex genetic interactions.
Autorzy:
Kuzmin E; The Donnelly Centre, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.; Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
VanderSluis B; Department of Computer Science and Engineering, University of Minnesota-Twin Cities, 200 Union Street, Minneapolis, MN 55455, USA.
Wang W; Department of Computer Science and Engineering, University of Minnesota-Twin Cities, 200 Union Street, Minneapolis, MN 55455, USA.
Tan G; The Donnelly Centre, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
Deshpande R; Department of Computer Science and Engineering, University of Minnesota-Twin Cities, 200 Union Street, Minneapolis, MN 55455, USA.
Chen Y; The Donnelly Centre, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
Usaj M; The Donnelly Centre, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
Balint A; The Donnelly Centre, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.; Department of Biochemistry, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
Mattiazzi Usaj M; The Donnelly Centre, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
van Leeuwen J; The Donnelly Centre, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
Koch EN; Department of Computer Science and Engineering, University of Minnesota-Twin Cities, 200 Union Street, Minneapolis, MN 55455, USA.
Pons C; Department of Computer Science and Engineering, University of Minnesota-Twin Cities, 200 Union Street, Minneapolis, MN 55455, USA.
Dagilis AJ; Department of Integrative Biology, 1 University Station C0990, University of Texas at Austin, Austin, TX 78712, USA.
Pryszlak M; The Donnelly Centre, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
Wang JZY; The Donnelly Centre, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.; Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
Hanchard J; The Donnelly Centre, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.; Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
Riggi M; Department of Molecular Biology, University of Geneva, Geneva 1211, Switzerland.; Department of Biochemistry, University of Geneva, 1211 Geneva, Switzerland.; iGE3 (Institute of Genetics and Genomics of Geneva), 1211 Geneva, Switzerland.; Swiss National Centre for Competence in Research Programme Chemical Biology, 1211 Geneva, Switzerland.
Xu K; Department of Computer Science and Engineering, University of Minnesota-Twin Cities, 200 Union Street, Minneapolis, MN 55455, USA.
Heydari H; The Donnelly Centre, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.; Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
San Luis BJ; The Donnelly Centre, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
Shuteriqi E; The Donnelly Centre, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
Zhu H; The Donnelly Centre, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
Van Dyk N; The Donnelly Centre, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
Sharifpoor S; The Donnelly Centre, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
Costanzo M; The Donnelly Centre, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
Loewith R; Department of Molecular Biology, University of Geneva, Geneva 1211, Switzerland.; iGE3 (Institute of Genetics and Genomics of Geneva), 1211 Geneva, Switzerland.; Swiss National Centre for Competence in Research Programme Chemical Biology, 1211 Geneva, Switzerland.
Caudy A; The Donnelly Centre, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.; Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
Bolnick D; Department of Integrative Biology, 1 University Station C0990, University of Texas at Austin, Austin, TX 78712, USA.
Brown GW; The Donnelly Centre, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.; Department of Biochemistry, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
Andrews BJ; The Donnelly Centre, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada. .; Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
Boone C; The Donnelly Centre, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada. .; Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.; RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan.
Myers CL; Department of Computer Science and Engineering, University of Minnesota-Twin Cities, 200 Union Street, Minneapolis, MN 55455, USA. .
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Źródło:
Science (New York, N.Y.) [Science] 2018 Apr 20; Vol. 360 (6386).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Gene Regulatory Networks*
Saccharomyces cerevisiae/*genetics
Saccharomyces cerevisiae Proteins/*genetics
Mutation ; Oligonucleotide Array Sequence Analysis
Czasopismo naukowe
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Tytuł:
Chemical genomic guided engineering of gamma-valerolactone tolerant yeast.
Autorzy:
Bottoms S; Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, 1552 University Ave, Madison, WI, USA.; Lehrstuhl für Chemie Biogener Rohstoffe, Technische Universität München, Schulgasse 16, 94315, Straubing, Germany.
Dickinson Q; Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, 1552 University Ave, Madison, WI, USA.; School of Biology, Georgia Institute of Technology, Atlanta, GA, USA.
McGee M; Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, 1552 University Ave, Madison, WI, USA.
Hinchman L; Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, 1552 University Ave, Madison, WI, USA.
Higbee A; University of Wisconsin Biotechnology Center, Madison, WI, USA.
Hebert A; Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI, USA.
Serate J; Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, 1552 University Ave, Madison, WI, USA.
Xie D; Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, 1552 University Ave, Madison, WI, USA.
Zhang Y; Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, 1552 University Ave, Madison, WI, USA.
Coon JJ; Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI, USA.; Morgridge Institute for Research, Madison, WI, USA.; Department of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.; Genome Center of Wisconsin, Madison, WI, USA.
Myers CL; Department of Computer Science and Engineering, University of Minnesota-Twin Cities, Minneapolis, MN, USA.
Landick R; Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, 1552 University Ave, Madison, WI, USA.
Piotrowski JS; Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, 1552 University Ave, Madison, WI, USA. .; Yumanity Therapeutics, 790 Memorial Drive, Suite 2C, Cambridge, MA, 02139, USA. .
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Źródło:
Microbial cell factories [Microb Cell Fact] 2018 Jan 12; Vol. 17 (1), pp. 5. Date of Electronic Publication: 2018 Jan 12.
Typ publikacji:
Journal Article
MeSH Terms:
Genetic Engineering/*methods
Genomics/*methods
Lactones/*pharmacology
Saccharomyces cerevisiae/*drug effects
Saccharomyces cerevisiae/*genetics
Biocatalysis ; Biofuels ; Biomass ; Carboxy-Lyases/deficiency ; Carboxy-Lyases/genetics ; Drug Resistance, Fungal ; Ergosterol/metabolism ; Ethanol/metabolism ; Ethanol/pharmacology ; Fermentation ; Lignin/metabolism ; Mutation ; Proteomics ; Saccharomyces cerevisiae/metabolism ; Xylose/metabolism
Czasopismo naukowe
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Tytuł:
Up For A Challenge (U4C): Stimulating innovation in breast cancer genetic epidemiology.
Autorzy:
Mechanic LE; Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
Lindström S; Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington, United States of America.
Daily KM; Sage Bionetworks, Seattle, Washington, United States of America.
Sieberts SK; Sage Bionetworks, Seattle, Washington, United States of America.
Amos CI; Department of Biomedical Data Sciences, Dartmouth College, Lebanon, New Hampshire, United States of America.
Chen HS; Surveillance Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
Cox NJ; Division of Genetic Medicine, Vanderbilt University, Nashville, Tennessee, United States of America.
Dathe M; Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
Feuer EJ; Surveillance Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
Guertin MJ; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, United States of America.
Hoffman J; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America.
Liu Y; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, United States of America.
Moore JH; Division of Informatics, Department of Biostatistics and Epidemiology, Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
Myers CL; Department of Computer Science and Engineering, University of Minnesota-Twin Cities, Minneapolis, Minnesota, United States of America.
Ritchie MD; Department of Biochemistry and Molecular Biology, Center for Systems Genomics, Pennsylvania State University, University Park, Pennsylvania, United States of America.; Biomedical and Translational Informatics, Geisinger Health System, Danville, Pennsylvania, United States of America.
Schildkraut J; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America.
Schumacher F; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America.
Witte JS; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America.
Wang W; Department of Computer Science and Engineering, University of Minnesota-Twin Cities, Minneapolis, Minnesota, United States of America.
Williams SM; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America.
Gillanders EM; Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
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Corporate Authors:
U4C Challenge Participants
U4C Challenge Data Contributors
Źródło:
PLoS genetics [PLoS Genet] 2017 Sep 28; Vol. 13 (9), pp. e1006945. Date of Electronic Publication: 2017 Sep 28 (Print Publication: 2017).
Typ publikacji:
Editorial; Research Support, N.I.H., Extramural
MeSH Terms:
Breast Neoplasms/*genetics
Genome-Wide Association Study/*methods
Breast Neoplasms/epidemiology ; Female ; Genome-Wide Association Study/statistics & numerical data ; Genome-Wide Association Study/trends ; Humans ; Inventions ; Research Report
Raport
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