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Tytuł :
Insights into the Activation Mechanism of the ALX/FPR2 Receptor.
Autorzy :
Schmitz Nunes V; Laboratório de Química Computacional Medicinal, UFTM, Uberaba, Minas Gerais 38015-050, Brazil.; Programa de Pós-Graduação em Modelagem Computacional, UFJF, Juiz de Fora, Minas Gerais 36036-330, Brazil.
Rogério AP; Laboratório de Imunofarmacologia Experimental, UFTM, Uberaba, Minas Gerais 38025-180, Brazil.
Abrahão O Jr; Laboratório de Química Computacional Medicinal, UFTM, Uberaba, Minas Gerais 38015-050, Brazil.
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Źródło :
The journal of physical chemistry letters [J Phys Chem Lett] 2020 Nov 05; Vol. 11 (21), pp. 8952-8957. Date of Electronic Publication: 2020 Oct 08.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*chemistry
Docosahexaenoic Acids/*chemistry
N-Formylmethionine Leucyl-Phenylalanine/*analogs & derivatives
Receptors, Formyl Peptide/*agonists
Receptors, Lipoxin/*agonists
Amino Acid Sequence ; Anti-Inflammatory Agents/pharmacology ; Cytoplasm/metabolism ; Cytoplasm/ultrastructure ; Docosahexaenoic Acids/pharmacology ; Glucocorticoids/chemistry ; Humans ; Molecular Dynamics Simulation ; N-Formylmethionine Leucyl-Phenylalanine/chemistry ; N-Formylmethionine Leucyl-Phenylalanine/pharmacology ; Protein Conformation ; Receptors, Formyl Peptide/metabolism ; Receptors, Lipoxin/metabolism ; Signal Transduction ; Static Electricity
Czasopismo naukowe
Tytuł :
The Systemic Immune Response in COVID-19 Is Associated with a Shift to Formyl-Peptide Unresponsive Eosinophils.
Autorzy :
Koenderman L; Department of Respiratory Medicine, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.; Center for Translational Immunology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.
Siemers MJ; Department of Respiratory Medicine, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.; Center for Translational Immunology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.
van Aalst C; Department of Respiratory Medicine, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.; Center for Translational Immunology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.
Bongers SH; Center for Translational Immunology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.; Department of Trauma Surgery, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.
Spijkerman R; Department of Respiratory Medicine, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.; Center for Translational Immunology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.
Bindels BJJ; Department of Respiratory Medicine, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.; Center for Translational Immunology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.
Giustarini G; Department of Respiratory Medicine, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.; Center for Translational Immunology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.
van Goor HMR; Department of Internal Medicine, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.
Kaasjager KAH; Department of Internal Medicine, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.
Vrisekoop N; Department of Respiratory Medicine, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.; Center for Translational Immunology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.
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Źródło :
Cells [Cells] 2021 May 05; Vol. 10 (5). Date of Electronic Publication: 2021 May 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunity, Innate*
COVID-19/*immunology
Eosinophils/*immunology
N-Formylmethionine Leucyl-Phenylalanine/*metabolism
SARS-CoV-2/*immunology
Adult ; COVID-19/blood ; COVID-19/diagnosis ; COVID-19/virology ; COVID-19 Nucleic Acid Testing ; Case-Control Studies ; Cell Separation ; Cohort Studies ; Eosinophils/metabolism ; Flow Cytometry ; Healthy Volunteers ; Humans ; Leukocyte Count ; RNA, Viral/isolation & purification ; SARS-CoV-2/isolation & purification ; Severity of Illness Index
Czasopismo naukowe
Tytuł :
Adjunctive Immunotherapeutic Efficacy of N-Formylated Internal Peptide of Mycobacterial Glutamine Synthetase in Mouse Model of Tuberculosis.
Autorzy :
Mir SA; Department of Biochemistry, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh - 160012, India.; Department of Medical Laboratory Sciences, College of Applied Medical Science, Majmaah University, Al Majmaah-11952, Saudi Arabia.
Sharma S; Department of Biochemistry, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh - 160012, India.
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Źródło :
Protein and peptide letters [Protein Pept Lett] 2020; Vol. 27 (3), pp. 236-242.
Typ publikacji :
Journal Article
MeSH Terms :
Glutamate-Ammonia Ligase/*chemistry
Isoniazid/*administration & dosage
Mycobacterium tuberculosis/*enzymology
N-Formylmethionine Leucyl-Phenylalanine/*administration & dosage
Rifampin/*administration & dosage
Tuberculosis/*drug therapy
Animals ; Bacterial Load/drug effects ; Bacterial Proteins/chemistry ; Bacterial Proteins/immunology ; Disease Models, Animal ; Drug Therapy, Combination ; Female ; Glutamate-Ammonia Ligase/immunology ; Isoniazid/pharmacology ; Lung/drug effects ; Lung/microbiology ; Mice ; Mycobacterium tuberculosis/immunology ; N-Formylmethionine Leucyl-Phenylalanine/immunology ; N-Formylmethionine Leucyl-Phenylalanine/pharmacology ; Neutrophils/drug effects ; Neutrophils/metabolism ; Reactive Oxygen Species/metabolism ; Rifampin/pharmacology ; Spleen/drug effects ; Spleen/microbiology ; Tuberculosis/immunology
Czasopismo naukowe
Tytuł :
Dynamic Changes in the Ability to Release Neutrophil ExtraCellular Traps in the Course of Childhood Acute Leukemias.
Autorzy :
Ostafin M; Department of Laboratory Diagnostics and Clinical Immunology of the Developmental Age, Medical University of Warsaw, 63A Żwirki i Wigury St., 02-091 Warsaw, Poland.
Ciepiela O; Department of Laboratory Diagnostics and Clinical Immunology of the Developmental Age, Medical University of Warsaw, 63A Żwirki i Wigury St., 02-091 Warsaw, Poland.; Department of Laboratory Medicine, Medical University of Warsaw, 1A Banacha St., 02-097 Warsaw, Poland.
Pruchniak M; Department of Laboratory Diagnostics and Clinical Immunology of the Developmental Age, Medical University of Warsaw, 63A Żwirki i Wigury St., 02-091 Warsaw, Poland.
Wachowska M; Department of Laboratory Diagnostics and Clinical Immunology of the Developmental Age, Medical University of Warsaw, 63A Żwirki i Wigury St., 02-091 Warsaw, Poland.
Ulińska E; Department of Pediatric Hematology and Oncology, Medical University of Warsaw, 63A Żwirki i Wigury St., 02-091 Warsaw, Poland.
Mrówka P; Department of Biophysics and Human Physiology, Medical University of Warsaw, 5A Chalubinskiego St., 02-004 Warsaw, Poland.; Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, 15 Indiry Gandhi St., 02-776 Warsaw, Poland.
Głodkowska-Mrówka E; Department of Laboratory Diagnostics and Clinical Immunology of the Developmental Age, Medical University of Warsaw, 63A Żwirki i Wigury St., 02-091 Warsaw, Poland.; Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, 15 Indiry Gandhi St., 02-776 Warsaw, Poland.; Department of Hematological and Transfusion Immunology, Institute of Hematology and Transfusion Medicine, 15 Indiry Gandhi St., 02-776 Warsaw, Poland.
Demkow U; Department of Laboratory Diagnostics and Clinical Immunology of the Developmental Age, Medical University of Warsaw, 63A Żwirki i Wigury St., 02-091 Warsaw, Poland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jan 15; Vol. 22 (2). Date of Electronic Publication: 2021 Jan 15.
Typ publikacji :
Journal Article
MeSH Terms :
Extracellular Traps/*immunology
Immunity, Innate/*immunology
Leukemia/*immunology
Neutrophils/*immunology
Acute Disease ; Adolescent ; Calcium Ionophores/pharmacology ; Cells, Cultured ; Child ; Child, Preschool ; Humans ; Immunity, Innate/drug effects ; Infant ; Leukemia/blood ; Leukemia/drug therapy ; N-Formylmethionine Leucyl-Phenylalanine/pharmacology ; Neutrophils/drug effects ; Neutrophils/metabolism ; Tetradecanoylphorbol Acetate/pharmacology
Czasopismo naukowe
Tytuł :
A new dimeric protoberberine alkaloid and other compounds from the tubers of Tinospora dentata .
Autorzy :
Lam SH; School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Jian SD; Chuang Song Zong Pharmaceutical Co., LTD, Kaohsiung City, Taiwan.
Hwang TL; Graduate Institute of Natural Products, School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan.; Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Chen PJ; Department of Cosmetic Science, Providence University, Taichung, Taiwan.
Hung HY; School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Kuo PC; School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Wu TS; School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Department of Pharmacy, College of Pharmacy and Health Care, Tajen University, Pingtung, Taiwan.
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Źródło :
Natural product research [Nat Prod Res] 2021 Jan; Vol. 35 (1), pp. 17-24. Date of Electronic Publication: 2019 May 28.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents, Non-Steroidal/*chemistry
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Tinospora/*chemistry
Alkaloids/chemistry ; Alkaloids/pharmacology ; Berberine Alkaloids/chemistry ; Cytochalasin B/pharmacology ; Humans ; Molecular Structure ; N-Formylmethionine Leucyl-Phenylalanine/pharmacology ; Neutrophils/drug effects ; Neutrophils/metabolism ; Pancreatic Elastase/metabolism ; Plant Tubers/chemistry ; Plants, Medicinal/chemistry ; Superoxides/metabolism
Czasopismo naukowe
Tytuł :
Estradiol inhibits fMLP-induced neutrophil migration and superoxide production by upregulating MKP-2 and dephosphorylating ERK.
Autorzy :
Zhang P; Institute of Hand Surgery, Ruihua Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215100, China.
Fu Y; Department of Human Anatomy, Histology and Embryology, School of Biology and Basic Medical Sciences, Soochow University, Suzhou, Jiangsu 215007, China.
Ju J; Department of Hand Surgery, Ruihua Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215100, China.
Wan D; Institute of Hand Surgery, Ruihua Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215100, China.
Su H; Institute of Hand Surgery, Ruihua Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215100, China.
Wang Z; Institute of Hand Surgery, Ruihua Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215100, China.
Rui H; Department of Clinical Laboratory, Ruihua Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215100, China.
Jin Q; Department of Hand Surgery, Ruihua Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215100, China.
Le Y; CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Hou R; Institute of Hand Surgery, Ruihua Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215100, China; Department of Hand Surgery, Ruihua Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215100, China. Electronic address: .
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Źródło :
International immunopharmacology [Int Immunopharmacol] 2019 Oct; Vol. 75, pp. 105787. Date of Electronic Publication: 2019 Aug 08.
Typ publikacji :
Journal Article
MeSH Terms :
N-Formylmethionine Leucyl-Phenylalanine*
Anti-Inflammatory Agents/*pharmacology
Chemotaxis, Leukocyte/*drug effects
Estradiol/*pharmacology
Estrogens/*pharmacology
Neutrophils/*drug effects
Superoxides/*metabolism
Dual-Specificity Phosphatases/metabolism ; Extracellular Signal-Regulated MAP Kinases/metabolism ; HL-60 Cells ; Humans ; Male ; Mitogen-Activated Protein Kinase Phosphatases/metabolism ; Neutrophils/physiology ; Phosphorylation/drug effects ; Up-Regulation/drug effects
Czasopismo naukowe
Tytuł :
A Genetic Model of Constitutively Active Integrin CD11b/CD18.
Autorzy :
Martinez L; DeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136.
Li X; Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612.
Ramos-Echazabal G; DeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136.
Faridi H; Department of Pharmaceutical Sciences, College of Pharmacy, Chicago State University, Chicago, IL 60612; and.
Zigmond ZM; Department of Molecular and Cellular Pharmacology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136.
Santos Falcon N; DeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136.
Hernandez DR; DeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136.
Shehadeh SA; DeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136.
Velazquez OC; DeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136.
Gupta V; Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612; .
Vazquez-Padron RI; DeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136; .
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2020 Nov 01; Vol. 205 (9), pp. 2545-2553. Date of Electronic Publication: 2020 Sep 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
CD11b Antigen/*genetics
CD18 Antigens/*genetics
Integrins/*genetics
Animals ; Cell Adhesion/genetics ; Chemotaxis, Leukocyte/genetics ; Disease Models, Animal ; Female ; Fibrinogen/genetics ; Leukocytes/metabolism ; Macrophages/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Models, Genetic ; N-Formylmethionine Leucyl-Phenylalanine/analogs & derivatives ; N-Formylmethionine Leucyl-Phenylalanine/metabolism ; Neutrophils/metabolism
Czasopismo naukowe
Tytuł :
The formyl peptide fMLF primes platelet activation and augments thrombus formation.
Autorzy :
Salamah MF; School of Pharmacy, University of Reading, Reading, UK.
Ravishankar D; School of Pharmacy, University of Reading, Reading, UK.
Vaiyapuri R; School of Pharmacy, University of Reading Malaysia, Johor, Malaysia.
Moraes LA; School of Pharmacy, University of Reading, Reading, UK.
Patel K; School of Biological Sciences, University of Reading, Reading, UK.
Perretti M; William Harvey Research Institute, Queen Mary University of London, London, UK.
Gibbins JM; School of Biological Sciences, University of Reading, Reading, UK.
Vaiyapuri S; School of Pharmacy, University of Reading, Reading, UK.
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Źródło :
Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2019 Jul; Vol. 17 (7), pp. 1120-1133. Date of Electronic Publication: 2019 May 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Blood Coagulation*
N-Formylmethionine Leucyl-Phenylalanine*
Platelet Activation*
Blood Platelets/*metabolism
Receptors, Formyl Peptide/*blood
Thrombosis/*chemically induced
Animals ; Cyclic AMP/blood ; Disease Models, Animal ; Humans ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, Formyl Peptide/deficiency ; Receptors, Formyl Peptide/genetics ; Signal Transduction ; Thrombosis/blood
Czasopismo naukowe
Tytuł :
Functional role of phosphatidylcholine-specific phospholipase C in regulating leukotriene synthesis and degranulation in human eosinophils.
Autorzy :
Sano A; Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, 377-2, Ohnohigashi Osakasayama, Osaka, 589-8511, Japan. Electronic address: .
Sano H; Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, 377-2, Ohnohigashi Osakasayama, Osaka, 589-8511, Japan.
Iwanaga T; Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, 377-2, Ohnohigashi Osakasayama, Osaka, 589-8511, Japan.
Tohda Y; Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, 377-2, Ohnohigashi Osakasayama, Osaka, 589-8511, Japan.
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2020 Oct 05; Vol. 884, pp. 173353. Date of Electronic Publication: 2020 Jul 22.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Degranulation*/drug effects
Eosinophils/*enzymology
Leukotrienes/*metabolism
Type C Phospholipases/*metabolism
Arachidonic Acid/metabolism ; Calcium Signaling ; Cytochalasin B/pharmacology ; Enzyme Activation ; Eosinophils/drug effects ; Group IV Phospholipases A2/metabolism ; Humans ; Leukotriene C4/metabolism ; N-Formylmethionine Leucyl-Phenylalanine/pharmacology ; Norbornanes/pharmacology ; Phosphodiesterase Inhibitors/pharmacology ; Signal Transduction ; Thiocarbamates/pharmacology ; Type C Phospholipases/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Formyl-methionine as an N-degron of a eukaryotic N-end rule pathway.
Autorzy :
Kim JM; Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, Republic of Korea.
Seok OH; Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, Republic of Korea.
Ju S; Center for Theragnosis, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea.; Department of Life Science and Research Institute for Natural Sciences, Hanyang University, Seoul 04763, Republic of Korea.
Heo JE; Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, Republic of Korea.
Yeom J; Center for Theragnosis, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea.; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Republic of Korea.
Kim DS; Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, Republic of Korea.
Yoo JY; Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, Republic of Korea.
Varshavsky A; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Lee C; Center for Theragnosis, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea. .; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Republic of Korea.; Department of Converging Science and Technology, KHU-KIST, Kyung Hee University, Seoul 02447, Republic of Korea.
Hwang CS; Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, Republic of Korea. .
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Źródło :
Science (New York, N.Y.) [Science] 2018 Nov 30; Vol. 362 (6418). Date of Electronic Publication: 2018 Nov 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Proteolysis*
Amino Acids/*deficiency
Hydroxymethyl and Formyl Transferases/*metabolism
N-Formylmethionine/*metabolism
Saccharomyces cerevisiae/*metabolism
Saccharomyces cerevisiae Proteins/*metabolism
Azides/pharmacology ; Cold Temperature ; Cytosol/metabolism ; Metabolic Networks and Pathways ; Mitochondria/enzymology ; N-Formylmethionine/chemistry ; Peptide Elongation Factors/metabolism ; Phosphorylation ; Protein-Serine-Threonine Kinases/metabolism ; Saccharomyces cerevisiae/drug effects ; Saccharomyces cerevisiae/enzymology ; Ubiquitin-Protein Ligases/metabolism ; Up-Regulation
Czasopismo naukowe
Tytuł :
Lipopeptide PAM3CYS4 Synergizes N-Formyl-Met-Leu-Phe (fMLP)-Induced Calcium Transients in Mouse Neutrophils.
Autorzy :
Ding R; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.; Department of Intensive Care Unit, The First Hospital of China Medical University, Shenyang, China.
Xu G; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Feng Y; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.; Department of Anesthesiology, Shock Trauma Anesthesiology Research Center, University of Maryland School of Medicine, Baltimore, Maryland.
Zou L; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.; Department of Anesthesiology, Shock Trauma Anesthesiology Research Center, University of Maryland School of Medicine, Baltimore, Maryland.
Chao W; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.; Department of Anesthesiology, Shock Trauma Anesthesiology Research Center, University of Maryland School of Medicine, Baltimore, Maryland.
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Źródło :
Shock (Augusta, Ga.) [Shock] 2018 Oct; Vol. 50 (4), pp. 493-499.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Calcium/*metabolism
Lipopeptides/*pharmacology
N-Formylmethionine Leucyl-Phenylalanine/*analogs & derivatives
Neutrophils/*drug effects
Neutrophils/*metabolism
Animals ; Lipopolysaccharides/pharmacology ; Mice ; Mice, Inbred C57BL ; Myeloid Differentiation Factor 88/metabolism ; N-Formylmethionine Leucyl-Phenylalanine/pharmacology ; Signal Transduction/drug effects ; Teichoic Acids/pharmacology ; Toll-Like Receptor 2/metabolism ; Toll-Like Receptor 4/metabolism
Czasopismo naukowe
Tytuł :
Role of the Intracellular Sodium Homeostasis in Chemotaxis of Activated Murine Neutrophils.
Autorzy :
Najder K; Institute of Physiology II, University Hospital Münster, Münster, Germany.
Rugi M; Institute of Physiology II, University Hospital Münster, Münster, Germany.; University of Florence, Florence, Italy.
Lebel M; University of Sherbrooke, Sherbrooke, QC, Canada.
Schröder J; Institute of Physiology II, University Hospital Münster, Münster, Germany.
Oster L; Institute of Physiology II, University Hospital Münster, Münster, Germany.
Schimmelpfennig S; Institute of Physiology II, University Hospital Münster, Münster, Germany.
Sargin S; Institute of Physiology II, University Hospital Münster, Münster, Germany.
Pethő Z; Institute of Physiology II, University Hospital Münster, Münster, Germany.
Bulk E; Institute of Physiology II, University Hospital Münster, Münster, Germany.
Schwab A; Institute of Physiology II, University Hospital Münster, Münster, Germany.
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Źródło :
Frontiers in immunology [Front Immunol] 2020 Sep 08; Vol. 11, pp. 2124. Date of Electronic Publication: 2020 Sep 08 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chemotaxis, Leukocyte/*immunology
Homeostasis/*immunology
Sodium/*physiology
TRPM Cation Channels/*physiology
Animals ; Calcium/physiology ; Cell Line, Tumor ; Cells, Cultured ; Chemotaxis, Leukocyte/drug effects ; Complement C5a/immunology ; Complement C5a/pharmacology ; Intracellular Fluid/immunology ; Leukemia, Myeloid ; Mice ; Mice, Inbred C57BL ; N-Formylmethionine Leucyl-Phenylalanine/pharmacology ; Neutrophil Activation/drug effects ; Sodium-Calcium Exchanger/physiology ; Sodium-Potassium-Exchanging ATPase/physiology ; TRPM Cation Channels/deficiency
Czasopismo naukowe
Tytuł :
Polymorphonuclear Cell Chemotaxis and Suicidal NETosis: Simultaneous Observation Using fMLP, PMA, H7, and Live Cell Imaging.
Autorzy :
Pai D; Department of Anesthesiology, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany.
Gruber M; Department of Anesthesiology, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany.
Pfaehler SM; Department of Anesthesiology, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany.
Bredthauer A; Department of Anesthesiology, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany.
Lehle K; Department of Cardiothoracic Surgery, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany.
Trabold B; Department of Anesthesiology, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany.
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Źródło :
Journal of immunology research [J Immunol Res] 2020 Aug 17; Vol. 2020, pp. 1415947. Date of Electronic Publication: 2020 Aug 17 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Chemotaxis, Leukocyte/*immunology
Extracellular Traps/*immunology
Extracellular Traps/*metabolism
Neutrophils/*physiology
Chemotaxis, Leukocyte/drug effects ; Humans ; Molecular Imaging/methods ; N-Formylmethionine Leucyl-Phenylalanine ; Oxidation-Reduction ; Reactive Oxygen Species ; Tetradecanoylphorbol Acetate/pharmacology ; Time-Lapse Imaging
Czasopismo naukowe
Tytuł :
Synthesis and evaluation of a [ F]formyl-Met-Leu-Phe derivative: A positron emission tomography imaging probe for bacterial infections.
Autorzy :
Kimura H; Department of Patho-Functional Bioanalysis, Kyoto University Graduate School of Pharmaceutical Sciences, 46-29, Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan; Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan. Electronic address: .
Yamauchi S; Department of Patho-Functional Bioanalysis, Kyoto University Graduate School of Pharmaceutical Sciences, 46-29, Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan.
Kawashima H; Radioisotope Research Center, Kyoto Pharmaceutical University, 1 Misasagi-shichono-cho, Yamashina-ku, Kyoto 607-8412, Japan; Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.
Arimitsu K; Department of Patho-Functional Bioanalysis, Kyoto University Graduate School of Pharmaceutical Sciences, 46-29, Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan; Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan.
Yagi Y; Department of Patho-Functional Bioanalysis, Kyoto University Graduate School of Pharmaceutical Sciences, 46-29, Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan; Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan.
Nakamoto Y; Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.
Togashi K; Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.
Ono M; Department of Patho-Functional Bioanalysis, Kyoto University Graduate School of Pharmaceutical Sciences, 46-29, Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan.
Saji H; Department of Patho-Functional Bioanalysis, Kyoto University Graduate School of Pharmaceutical Sciences, 46-29, Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2018 Sep 15; Vol. 28 (17), pp. 2949-2952. Date of Electronic Publication: 2018 Jul 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Positron-Emission Tomography*
Escherichia coli Infections/*diagnostic imaging
Molecular Probes/*chemistry
N-Formylmethionine Leucyl-Phenylalanine/*chemistry
Dose-Response Relationship, Drug ; Fluorine Radioisotopes ; Molecular Probes/chemical synthesis ; Molecular Structure ; N-Formylmethionine Leucyl-Phenylalanine/chemical synthesis ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Anti-inflammatory alkaloids from the root bark of Hernandia nymphaeifolia.
Autorzy :
Lai YW; Division of Urology, Taipei City Hospital Renai Branch, Taipei, Taiwan; Department of Urology, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Wang SW; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Medicine, Mackay Medical College, New Taipei City, Taiwan.
Hu YY; Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung, Taiwan.
Hwang TL; Graduate Institute of Natural Products, School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan.
Cheng MJ; Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu, Taiwan.
Chen IS; School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.
Sung PJ; National Museum of Marine Biology and Aquarium, Pingtung, Taiwan; Department of Medicine, Mackay Medical College, New Taipei City, Taiwan.
Chen JJ; Faculty of Pharmacy, School of Pharmaceutical Sciences, National Yang-Ming University, Taipei, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan. Electronic address: .
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Źródło :
Phytochemistry [Phytochemistry] 2020 May; Vol. 173, pp. 112326. Date of Electronic Publication: 2020 Feb 28.
Typ publikacji :
Journal Article
MeSH Terms :
Alkaloids*
Hernandiaceae*
Anti-Inflammatory Agents ; N-Formylmethionine Leucyl-Phenylalanine ; Neutrophils ; Pancreatic Elastase ; Plant Bark ; Superoxides
Czasopismo naukowe
Tytuł :
Hv1/VSOP regulates neutrophil directional migration and ERK activity by tuning ROS production.
Autorzy :
Okochi Y; Integrative Physiology, Graduate School of Medicine, Osaka University, Osaka, Japan.
Umemoto E; Laboratory of Microbiology and Immunology, School of Pharmaceutical Sciences, University of Shizuoka, Japan.
Okamura Y; Integrative Physiology, Graduate School of Medicine, Osaka University, Osaka, Japan.; Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2020 May; Vol. 107 (5), pp. 819-831. Date of Electronic Publication: 2020 Apr 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chemotaxis, Leukocyte/*physiology
Ion Channels/*metabolism
MAP Kinase Signaling System/*physiology
Neutrophils/*metabolism
Reactive Oxygen Species/*metabolism
Animals ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; N-Formylmethionine Leucyl-Phenylalanine/pharmacology
Czasopismo naukowe
Tytuł :
Simultaneous recording of intra- and inter-residue linking experiments for backbone assignments in proteins at MAS frequencies higher than 60 kHz.
Autorzy :
Sharma K; TIFR Centre for Interdisciplinary Sciences, Tata Institute of Fundamental Research Hyderabad, 36/P Gopanpally, Serlingampally Mandal, Rangareddy District, Hyderabad, 500107, India.
Madhu PK; TIFR Centre for Interdisciplinary Sciences, Tata Institute of Fundamental Research Hyderabad, 36/P Gopanpally, Serlingampally Mandal, Rangareddy District, Hyderabad, 500107, India.
Agarwal V; TIFR Centre for Interdisciplinary Sciences, Tata Institute of Fundamental Research Hyderabad, 36/P Gopanpally, Serlingampally Mandal, Rangareddy District, Hyderabad, 500107, India. .
Mote KR; TIFR Centre for Interdisciplinary Sciences, Tata Institute of Fundamental Research Hyderabad, 36/P Gopanpally, Serlingampally Mandal, Rangareddy District, Hyderabad, 500107, India. .
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Źródło :
Journal of biomolecular NMR [J Biomol NMR] 2020 May; Vol. 74 (4-5), pp. 229-237. Date of Electronic Publication: 2020 Jan 01.
Typ publikacji :
Journal Article
MeSH Terms :
Nuclear Magnetic Resonance, Biomolecular/*methods
Carbon Isotopes ; N-Formylmethionine Leucyl-Phenylalanine/chemistry ; Nitrogen Isotopes
Czasopismo naukowe
Tytuł :
A synthesized heterocyclic chalcone inhibits neutrophilic inflammation through K -dependent pH regulation.
Autorzy :
Yang SC; Department of Anesthesiology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan.; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Wang YH; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Division of Natural Products, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Tsai YF; Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Chang YW; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Wu TS; Department of Pharmacy, College of Pharmacy and Health Care, Tajen University, Pingtung, Taiwan.; School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Ho CM; Department of Anesthesiology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan.
Hwang TL; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Division of Natural Products, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.; Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, and Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan.; Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan.; Department of Chemical Engineering, Ming Chi University of Technology, New Taipei City, Taiwan.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2020 May; Vol. 34 (5), pp. 7127-7143. Date of Electronic Publication: 2020 Apr 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chalcones/*pharmacology
Morpholines/*pharmacology
Neutrophils/*drug effects
Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Calcium Signaling/drug effects ; Cell Degranulation/drug effects ; Cell Movement/drug effects ; Chalcones/chemical synthesis ; Chalcones/chemistry ; Humans ; Hydrogen-Ion Concentration ; In Vitro Techniques ; Inflammation/drug therapy ; Inflammation/metabolism ; Inflammation/pathology ; Morpholines/chemical synthesis ; Morpholines/chemistry ; N-Formylmethionine Leucyl-Phenylalanine/pharmacology ; Neutrophil Activation/drug effects ; Neutrophils/pathology ; Neutrophils/physiology ; Potassium/metabolism ; Respiratory Burst/drug effects
Czasopismo naukowe
Tytuł :
Immune profile of hyaluronic acid hydrogel polyethylene glycol crosslinked: An in vitro evaluation in human polymorphonuclear leukocytes.
Autorzy :
Marino F; Department of Medicine and Surgery, University of Insubria, Varese, Italy.
Cosentino M; Department of Medicine and Surgery, University of Insubria, Varese, Italy.
Legnaro M; Department of Medicine and Surgery, University of Insubria, Varese, Italy.
Luini A; Department of Medicine and Surgery, University of Insubria, Varese, Italy.
Sigova J; Department of Neonatology, Faculty of Continued Medical Education of Pirogov Russian National Research Medical University, Moscow, Russia.
Mocchi R; UB-CARE, Laboratories of the University of Pavia, Pavia, Italy.
Lotti T; Department of Dermatology, Guglielmo Marconi University, Rome, Italy.
Zerbinati N; Department of Medicine and Surgery, University of Insubria, Varese, Italy.
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Źródło :
Dermatologic therapy [Dermatol Ther] 2020 May; Vol. 33 (3), pp. e13388. Date of Electronic Publication: 2020 May 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hyaluronic Acid*/pharmacology
Neutrophils*
Humans ; Hydrogels ; N-Formylmethionine Leucyl-Phenylalanine/pharmacology ; Polyethylene Glycols/pharmacology
Czasopismo naukowe
Tytuł :
Structural basis of ligand binding modes at the human formyl peptide receptor 2.
Autorzy :
Chen T; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, 201203, Pudong, Shanghai, China.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, 201203, Pudong, Shanghai, China.; University of Chinese Academy of Sciences, No.19A Yuquan Road, 100049, Beijing, China.
Xiong M; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, 201203, Pudong, Shanghai, China.; University of Chinese Academy of Sciences, No.19A Yuquan Road, 100049, Beijing, China.
Zong X; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, 201203, Pudong, Shanghai, China.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, 201203, Pudong, Shanghai, China.; University of Chinese Academy of Sciences, No.19A Yuquan Road, 100049, Beijing, China.
Ge Y; Institute of Chinese Medical Sciences, University of Macau, 999078, Macau Special Administrative Region, China.
Zhang H; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, 201203, Pudong, Shanghai, China.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, 201203, Pudong, Shanghai, China.; University of Chinese Academy of Sciences, No.19A Yuquan Road, 100049, Beijing, China.
Wang M; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, 201203, Pudong, Shanghai, China.; School of Life Science and Technology, ShanghaiTech University, 393 Hua Xia Zhong Road, 201210, Shanghai, China.
Won Han G; Department of Chemistry, Bridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, 1002 West Childs Way, Los Angeles, CA, 90089, USA.
Yi C; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, 201203, Pudong, Shanghai, China.
Ma L; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, 201203, Pudong, Shanghai, China.
Ye RD; School of Life and Health Sciences, The Chinese University of Hong Kong, 518172, Shenzhen, China.
Xu Y; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, 201203, Pudong, Shanghai, China. .; University of Chinese Academy of Sciences, No.19A Yuquan Road, 100049, Beijing, China. .
Zhao Q; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, 201203, Pudong, Shanghai, China. .; University of Chinese Academy of Sciences, No.19A Yuquan Road, 100049, Beijing, China. .
Wu B; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, 201203, Pudong, Shanghai, China. .; University of Chinese Academy of Sciences, No.19A Yuquan Road, 100049, Beijing, China. .; School of Life Science and Technology, ShanghaiTech University, 393 Hua Xia Zhong Road, 201210, Shanghai, China. .
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Źródło :
Nature communications [Nat Commun] 2020 Mar 05; Vol. 11 (1), pp. 1208. Date of Electronic Publication: 2020 Mar 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Receptors, Formyl Peptide/*chemistry
Receptors, Formyl Peptide/*metabolism
Receptors, Lipoxin/*chemistry
Receptors, Lipoxin/*metabolism
Amino Acid Sequence ; Binding Sites ; Humans ; Ligands ; Molecular Docking Simulation ; Mutation/genetics ; N-Formylmethionine Leucyl-Phenylalanine/chemistry ; N-Formylmethionine Leucyl-Phenylalanine/metabolism ; Protein Conformation ; Signal Transduction ; Structure-Activity Relationship
Czasopismo naukowe

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