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Tytuł:
Binding of N-methylscopolamine to the extracellular domain of muscarinic acetylcholine receptors.
Autorzy:
Jakubík J; Institute of Physiology, Czech Academy of Sciences, 14220 Prague, Czech Republic.
Randáková A; Institute of Physiology, Czech Academy of Sciences, 14220 Prague, Czech Republic.
Zimčík P; Institute of Physiology, Czech Academy of Sciences, 14220 Prague, Czech Republic.
El-Fakahany EE; Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Minneapolis, MN 55455, USA (EEE).
Doležal V; Institute of Physiology, Czech Academy of Sciences, 14220 Prague, Czech Republic.
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Źródło:
Scientific reports [Sci Rep] 2017 Jan 16; Vol. 7, pp. 40381. Date of Electronic Publication: 2017 Jan 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
N-Methylscopolamine/*metabolism
Receptors, Muscarinic/*chemistry
Receptors, Muscarinic/*metabolism
Acceleration ; Animals ; Binding Sites ; CHO Cells ; Cricetinae ; Cricetulus ; Humans ; Kinetics ; Ligands ; Models, Biological ; Molecular Dynamics Simulation ; Mutant Proteins/chemistry ; Mutant Proteins/metabolism ; N-Methylscopolamine/chemistry ; Protein Binding ; Protein Domains ; Protein Structure, Secondary ; Tritium/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
50 years ago in The Journal of Pediatrics: congenital pyloric stenosis: a controlled evaluation of medical treatment utilizing methyl-scopolamine-nitrate.
Autorzy:
Gisser JM; Gastroenterology and Nutrition, Nationwide Children's Hospital, Columbus, Ohio.
Hill ID; Gastroenterology and Nutrition, Nationwide Children's Hospital, Columbus, Ohio.
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Źródło:
The Journal of pediatrics [J Pediatr] 2015 Mar; Vol. 166 (3), pp. 593.
Typ publikacji:
Historical Article; Journal Article
MeSH Terms:
N-Methylscopolamine/*history
Parasympatholytics/*history
Pediatrics/*history
Pyloric Stenosis/*history
Child ; History, 20th Century ; Humans ; N-Methylscopolamine/therapeutic use ; Parasympatholytics/therapeutic use ; Pyloric Stenosis/congenital ; Pyloric Stenosis/drug therapy
Czasopismo naukowe
Szczegóły
Tytuł:
Widespread Changes in Positive Allosteric Modulation of the Muscarinic M1 Receptor in Some Participants With Schizophrenia.
Autorzy:
Hopper S; The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.; Cooperative Research Centre for Mental Health, Parkville, Victoria, Australia.
Pavey GM; The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.
Gogos A; The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.
Dean B; The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.; Cooperative Research Centre for Mental Health, Parkville, Victoria, Australia.; The Centre for Mental Health, Swinburne University, Hawthorn, Victoria, Australia.
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Źródło:
The international journal of neuropsychopharmacology [Int J Neuropsychopharmacol] 2019 Oct 01; Vol. 22 (10), pp. 640-650.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Allosteric Regulation*
Receptor, Muscarinic M1/*agonists
Schizophrenia/*metabolism
Autoradiography ; Case-Control Studies ; Cerebral Cortex/metabolism ; Corpus Striatum/metabolism ; Female ; Hippocampus/metabolism ; Humans ; Male ; Middle Aged ; N-Methylscopolamine/metabolism ; Protein Binding/drug effects ; Quinolones/metabolism ; Radioligand Assay/methods ; Receptor, Muscarinic M1/deficiency ; Tritium/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Synthesis of novel and functionally selective non-competitive muscarinic antagonists as chemical probes.
Autorzy:
Boulos JF; Department of Physical Sciences, Barry University, Miami Shores, FL, USA.
Jakubik J; Department of Neurochemistry, Institute of Physiology of the Academy of Sciences of the Czech Republic, Prague, Czech Republic.
Boulos JM; Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.
Randakova A; Department of Neurochemistry, Institute of Physiology of the Academy of Sciences of the Czech Republic, Prague, Czech Republic.
Momirov J; Department of Physical Sciences, Barry University, Miami Shores, FL, USA.
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Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2018 Jan; Vol. 91 (1), pp. 93-104. Date of Electronic Publication: 2017 Jul 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Muscarinic Antagonists/*chemical synthesis
Receptors, Muscarinic/*metabolism
Acetylcholinesterase/metabolism ; Allosteric Regulation ; Animals ; Binding Sites ; CHO Cells ; Cricetinae ; Cricetulus ; Drug Design ; Humans ; Ligands ; Muscarinic Antagonists/chemistry ; Muscarinic Antagonists/metabolism ; N-Methylscopolamine/chemical synthesis ; N-Methylscopolamine/chemistry ; N-Methylscopolamine/metabolism ; Pilot Projects ; Protein Isoforms/chemistry ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Pyridines/chemistry ; Receptors, Muscarinic/chemistry ; Receptors, Muscarinic/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Characterization of methanthelinium binding and function at human M 1 -M 5 muscarinic acetylcholine receptors.
Autorzy:
Irmen M; Pharmacology and Toxicology, Institute of Pharmacy, University of Bonn, Gerhard-Domagk-Straße 3, 53121, Bonn, Germany.
Holze J; Pharmacology and Toxicology, Institute of Pharmacy, University of Bonn, Gerhard-Domagk-Straße 3, 53121, Bonn, Germany.
Bödefeld T; Pharmacology and Toxicology, Institute of Pharmacy, University of Bonn, Gerhard-Domagk-Straße 3, 53121, Bonn, Germany.
Tränkle C; Pharmacology and Toxicology, Institute of Pharmacy, University of Bonn, Gerhard-Domagk-Straße 3, 53121, Bonn, Germany. .
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Źródło:
Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2018 Oct; Vol. 391 (10), pp. 1037-1052. Date of Electronic Publication: 2018 Jun 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Methantheline/*pharmacology
Muscarinic Antagonists/*pharmacology
Receptors, Muscarinic/*metabolism
Animals ; Binding, Competitive ; CHO Cells ; Cricetulus ; Humans ; N-Methylscopolamine/pharmacology ; Protein Binding ; Radioligand Assay ; Receptors, Muscarinic/genetics
Czasopismo naukowe
Szczegóły
Tytuł:
Structure-Based Design and Discovery of New M 2 Receptor Agonists.
Autorzy:
Fish I; Department of Pharmaceutical Chemistry, University of California, San Francisco , San Francisco, California 94158, United States.; Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences, Tel-Aviv University , Ramat Aviv, Israel.
Stößel A; Department of Chemistry and Pharmacy, Medicinal Chemistry, Emil Fischer Center, Friedrich Alexander University , Schuhstraße 19, 91052 Erlangen, Germany.
Eitel K; Department of Chemistry and Pharmacy, Medicinal Chemistry, Emil Fischer Center, Friedrich Alexander University , Schuhstraße 19, 91052 Erlangen, Germany.
Valant C; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville Victoria 3052, Australia.
Albold S; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville Victoria 3052, Australia.
Huebner H; Department of Chemistry and Pharmacy, Medicinal Chemistry, Emil Fischer Center, Friedrich Alexander University , Schuhstraße 19, 91052 Erlangen, Germany.
Möller D; Department of Chemistry and Pharmacy, Medicinal Chemistry, Emil Fischer Center, Friedrich Alexander University , Schuhstraße 19, 91052 Erlangen, Germany.
Clark MJ; Department of Pharmacology, University of California, San Diego , La Jolla, California 92093, United States.
Sunahara RK; Department of Pharmacology, University of California, San Diego , La Jolla, California 92093, United States.
Christopoulos A; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville Victoria 3052, Australia.
Shoichet BK; Department of Pharmaceutical Chemistry, University of California, San Francisco , San Francisco, California 94158, United States.
Gmeiner P; Department of Chemistry and Pharmacy, Medicinal Chemistry, Emil Fischer Center, Friedrich Alexander University , Schuhstraße 19, 91052 Erlangen, Germany.
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Źródło:
Journal of medicinal chemistry [J Med Chem] 2017 Nov 22; Vol. 60 (22), pp. 9239-9250. Date of Electronic Publication: 2017 Nov 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Muscarinic Agonists/*pharmacology
Receptor, Muscarinic M2/*agonists
Acetylcholine/metabolism ; Animals ; Arrestin/metabolism ; Benzofurans/chemical synthesis ; Benzofurans/chemistry ; Benzofurans/pharmacology ; CHO Cells ; Carbachol/pharmacology ; Cricetulus ; Drug Design ; HEK293 Cells ; Humans ; Isoxazoles/pharmacology ; Ligands ; Molecular Docking Simulation ; Muscarinic Agonists/chemical synthesis ; Muscarinic Agonists/chemistry ; N-Methylscopolamine/chemistry ; Quaternary Ammonium Compounds/chemical synthesis ; Quaternary Ammonium Compounds/chemistry ; Quaternary Ammonium Compounds/pharmacology ; Receptor, Muscarinic M1/agonists ; Receptor, Muscarinic M1/chemistry ; Receptor, Muscarinic M1/metabolism ; Receptor, Muscarinic M2/chemistry ; Receptor, Muscarinic M2/metabolism ; Receptor, Muscarinic M3/agonists ; Receptor, Muscarinic M3/chemistry ; Receptor, Muscarinic M3/metabolism ; Receptors, Nicotinic/chemistry ; Tritium
Czasopismo naukowe
Szczegóły
Tytuł:
Mice with conditional NeuroD1 knockout display reduced aberrant hippocampal neurogenesis but no change in epileptic seizures.
Autorzy:
Brulet R; Department of Molecular Biology and Hamon Center for Regenerative Science and Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Zhu J; Department of Molecular Biology and Hamon Center for Regenerative Science and Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Aktar M; Department of Molecular Biology and Hamon Center for Regenerative Science and Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Hsieh J; Department of Molecular Biology and Hamon Center for Regenerative Science and Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: .
Cho KO; Department of Pharmacology, Catholic Neuroscience Institute, School of Medicine, The Catholic University of Korea, Seoul 06591, South Korea. Electronic address: .
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Źródło:
Experimental neurology [Exp Neurol] 2017 Jul; Vol. 293, pp. 190-198. Date of Electronic Publication: 2017 Apr 18.
Typ publikacji:
Journal Article
MeSH Terms:
Basic Helix-Loop-Helix Transcription Factors/*deficiency
Epilepsy/*genetics
Epilepsy/*pathology
Hippocampus/*physiopathology
Neurogenesis/*physiology
Up-Regulation/*genetics
Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Disease Models, Animal ; Doublecortin Domain Proteins ; Epilepsy/chemically induced ; Female ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/genetics ; Homeodomain Proteins/metabolism ; Luminescent Proteins/genetics ; Luminescent Proteins/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Microtubule-Associated Proteins/metabolism ; Muscarinic Agonists/toxicity ; N-Methylscopolamine/toxicity ; Nestin/genetics ; Nestin/metabolism ; Neurogenesis/drug effects ; Neurogenesis/genetics ; Neurons/metabolism ; Neurons/pathology ; Neuropeptides/metabolism ; Pilocarpine/toxicity ; Tumor Suppressor Proteins/metabolism ; Up-Regulation/drug effects
Czasopismo naukowe
Szczegóły
Tytuł:
Therapeutic effects of anti-HMGB1 monoclonal antibody on pilocarpine-induced status epilepticus in mice.
Autorzy:
Fu L; Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, 700-8558, Japan.
Liu K; Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, 700-8558, Japan.
Wake H; Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, 700-8558, Japan.
Teshigawara K; Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, 700-8558, Japan.
Yoshino T; Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, 700-8558, Japan.
Takahashi H; Department of Pharmacology, Kinki University School of Medicine, Osakasayama, 589-8511, Japan.
Mori S; School of Pharmacy, Pharmacology, Shujitsu University, Okayama, 703-8516, Japan.
Nishibori M; Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, 700-8558, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2017 Apr 26; Vol. 7 (1), pp. 1179. Date of Electronic Publication: 2017 Apr 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antibodies, Monoclonal/*administration & dosage
HMGB1 Protein/*antagonists & inhibitors
Immunologic Factors/*administration & dosage
Status Epilepticus/*drug therapy
Animals ; Blood-Brain Barrier/drug effects ; Blood-Brain Barrier/physiopathology ; Cerebral Cortex/pathology ; Female ; Hippocampus/pathology ; Mice, Inbred C57BL ; N-Methylscopolamine/toxicity ; Pilocarpine/toxicity ; Status Epilepticus/chemically induced ; Treatment Outcome
Czasopismo naukowe
Szczegóły
Tytuł:
Reduced NPY Y1 receptor hippocampal expression and signs of decreased vagal modulation of heart rate in mice.
Autorzy:
Statello R; Department of Neuroscience, University of Parma, Italy.
Carnevali L; Department of Neuroscience, University of Parma, Italy.
Paterlini S; Department of Neuroscience, University of Parma, Italy.
Gioiosa L; Department of Neuroscience, University of Parma, Italy.
Bertocchi I; Neuroscience Institute Cavalieri-Ottolenghi Foundation, University of Turin, Italy.
Oberto A; Neuroscience Institute Cavalieri-Ottolenghi Foundation, University of Turin, Italy.
Eva C; Neuroscience Institute Cavalieri-Ottolenghi Foundation, University of Turin, Italy.
Palanza P; Department of Neuroscience, University of Parma, Italy.
Sgoifo A; Department of Neuroscience, University of Parma, Italy. Electronic address: .
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Źródło:
Physiology & behavior [Physiol Behav] 2017 Apr 01; Vol. 172, pp. 31-39. Date of Electronic Publication: 2016 Jul 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Heart Rate/*physiology
Hippocampus/*metabolism
Receptors, Neuropeptide Y/*biosynthesis
Receptors, Neuropeptide Y/*physiology
Vagus Nerve/*physiology
Animals ; Male ; Mice ; Mice, Knockout ; N-Methylscopolamine/pharmacology ; Stress, Psychological/physiopathology ; Telemetry ; Vagus Nerve/drug effects
Czasopismo naukowe
Szczegóły
Tytuł:
Midazolam-ketamine dual therapy stops cholinergic status epilepticus and reduces Morris water maze deficits.
Autorzy:
Niquet J; Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, U.S.A.; Epilepsy Research Laboratory (151), Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, U.S.A.
Baldwin R; Epilepsy Research Laboratory (151), Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, U.S.A.
Norman K; Epilepsy Research Laboratory (151), Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, U.S.A.
Suchomelova L; Epilepsy Research Laboratory (151), Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, U.S.A.
Lumley L; US Army Medical Research Institute of Chemical Defense (USAMRICD), Aberdeen Proving Ground, Maryland, U.S.A.
Wasterlain CG; Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, U.S.A.; Epilepsy Research Laboratory (151), Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, U.S.A.; Brain Research Institute, David Geffen School of Medicine at UCLA, Los Angeles, California, U.S.A.
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Źródło:
Epilepsia [Epilepsia] 2016 Sep; Vol. 57 (9), pp. 1406-15. Date of Electronic Publication: 2016 Aug 08.
Typ publikacji:
Journal Article
MeSH Terms:
Status Epilepticus*/chemically induced
Status Epilepticus*/drug therapy
Status Epilepticus*/pathology
Anticonvulsants/*therapeutic use
Cholinergic Agents/*toxicity
Ketamine/*therapeutic use
Learning Disabilities/*drug therapy
Maze Learning/*drug effects
Midazolam/*therapeutic use
Animals ; Brain/pathology ; Disease Models, Animal ; Drug Synergism ; Drug Therapy, Combination ; Learning Disabilities/etiology ; Lithium Chloride/toxicity ; Male ; N-Methylscopolamine/toxicity ; Pilocarpine/toxicity ; Rats ; Rats, Sprague-Dawley ; Valproic Acid/therapeutic use
Czasopismo naukowe
Szczegóły
Tytuł:
Segment-dependent expression of muscarinic acetylcholine receptors and G-protein coupling in the equine respiratory tract.
Autorzy:
Abraham G; Institute of Pharmacology, Pharmacy and Toxicology, Leipzig University, Leipzig.
Kottke C
Ammer H
Dhein S
Ungemach FR
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Źródło:
Veterinary research communications [Vet Res Commun] 2007 Feb; Vol. 31 (2), pp. 207-26. Date of Electronic Publication: 2006 Dec 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
GTP-Binding Proteins/*metabolism
Horse Diseases/*metabolism
N-Methylscopolamine/*pharmacokinetics
Pulmonary Disease, Chronic Obstructive/*veterinary
Receptors, Muscarinic/*metabolism
Adenylyl Cyclases/metabolism ; Animals ; Binding, Competitive ; Blotting, Western/veterinary ; Horse Diseases/drug therapy ; Horses ; In Vitro Techniques ; Muscarinic Agonists/pharmacology ; Muscarinic Antagonists/pharmacology ; N-Methylscopolamine/antagonists & inhibitors ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Pulmonary Disease, Chronic Obstructive/metabolism ; Receptors, Muscarinic/biosynthesis ; Receptors, Muscarinic/drug effects ; Respiratory System/drug effects ; Respiratory System/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Kinetic evidence for different mechanisms of interaction of black mamba toxins MT alpha and MT beta with muscarinic receptors.
Autorzy:
Jolkkonen M; Department of Physiology, Biomedical Centre, Uppsala University, Sweden. />Oras A
Toomela T
Karlsson E
Järv J
Akerman KE
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Źródło:
Toxicon : official journal of the International Society on Toxinology [Toxicon] 2001 Feb-Mar; Vol. 39 (2-3), pp. 377-82.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Elapidae*
Elapid Venoms/*metabolism
Elapid Venoms/*toxicity
N-Methylscopolamine/*metabolism
Parasympatholytics/*metabolism
Receptors, Muscarinic/*drug effects
Animals ; Brain/drug effects ; Brain/metabolism ; Drug Interactions ; Kinetics ; N-Methylscopolamine/pharmacokinetics ; Parasympatholytics/pharmacokinetics ; Radioligand Assay ; Rats ; Receptors, Muscarinic/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Modes of allosteric interactions with free and [3H]N-methylscopolamine-occupied muscarinic M2 receptors as deduced from buffer-dependent potency shifts.
Autorzy:
Schröter A; Department of Pharmacology and Toxicology, Institute of Pharmacy, University of Bonn, Germany.
Tränkle C
Mohr K
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Źródło:
Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2000 Dec; Vol. 362 (6), pp. 512-9.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cholinergic Agents/*metabolism
N-Methylscopolamine/*metabolism
Receptors, Muscarinic/*metabolism
Alcuronium/metabolism ; Alcuronium/pharmacology ; Animals ; Binding Sites ; Binding, Competitive ; Buffers ; Cholinergic Agents/pharmacology ; Dose-Response Relationship, Drug ; Gallamine Triethiodide/metabolism ; Gallamine Triethiodide/pharmacology ; Kinetics ; Muscarinic Antagonists/metabolism ; Myocardium/metabolism ; N-Methylscopolamine/pharmacology ; Nicotinic Agonists/metabolism ; Nicotinic Agonists/pharmacology ; Pyridinium Compounds/metabolism ; Pyridinium Compounds/pharmacology ; Receptor, Muscarinic M2 ; Swine ; Tritium
Czasopismo naukowe
Szczegóły
Tytuł:
Apolipoprotein E4 reduces evoked hippocampal acetylcholine release in adult mice.
Autorzy:
Dolejší E; Department of Neurochemistry, Institute of Physiology CAS, Vídeňská, Czech Republic.
Liraz O; Department of Neurobiology, Sagol School of Neurosciences, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.
Rudajev V; Department of Neurochemistry, Institute of Physiology CAS, Vídeňská, Czech Republic.
Zimčík P; Department of Neurochemistry, Institute of Physiology CAS, Vídeňská, Czech Republic.
Doležal V; Department of Neurochemistry, Institute of Physiology CAS, Vídeňská, Czech Republic.
Michaelson DM; Department of Neurobiology, Sagol School of Neurosciences, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.
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Źródło:
Journal of neurochemistry [J Neurochem] 2016 Feb; Vol. 136 (3), pp. 503-9. Date of Electronic Publication: 2015 Nov 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Acetylcholine/*metabolism
Apolipoprotein E4/*metabolism
Hippocampus/*metabolism
Age Factors ; Animals ; Apolipoprotein E3/genetics ; Apolipoprotein E4/genetics ; Choline O-Acetyltransferase/metabolism ; Guanosine 5'-O-(3-Thiotriphosphate)/pharmacology ; Hippocampus/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; N-Methylscopolamine/pharmacology ; Receptors, Muscarinic/metabolism ; Tritium/metabolism ; Vesicular Acetylcholine Transport Proteins/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Investigation of the presence and antinociceptive function of muscarinic acetylcholine receptors in the African naked mole-rat (Heterocephalus glaber).
Autorzy:
Jørgensen KB; Department of Experimental Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamvej 3B, 2200, Copenhagen, Denmark.
Krogh-Jensen K; Department of Experimental Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamvej 3B, 2200, Copenhagen, Denmark.
Pickering DS; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen, Denmark.
Kanui TI; School of Agricultural and Veterinary Sciences, South Eastern Kenya University, P.O. BOX 170-90200, Kitui, Kenya.
Abelson KS; Department of Experimental Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamvej 3B, 2200, Copenhagen, Denmark. .
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Źródło:
Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology [J Comp Physiol A Neuroethol Sens Neural Behav Physiol] 2016 Jan; Vol. 202 (1), pp. 7-15. Date of Electronic Publication: 2015 Oct 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mole Rats/*physiology
Nociception/*physiology
Receptors, Muscarinic/*metabolism
Animals ; Female ; Formaldehyde ; Male ; Mole Rats/genetics ; Muscarinic Agonists/pharmacology ; N-Methylscopolamine ; Nociception/drug effects ; Pyridines/pharmacology ; Radioligand Assay ; Radiopharmaceuticals ; Receptors, Muscarinic/genetics ; Spinal Cord/drug effects ; Spinal Cord/metabolism ; Thiadiazoles/pharmacology ; Thiophenes/pharmacology ; Tritium
Czasopismo naukowe
Szczegóły
Tytuł:
New insight into active muscarinic receptors with the novel radioagonist [³H]iperoxo.
Autorzy:
Schrage R; Pharmacology & Toxicology Section, Institute of Pharmacy, University of Bonn, Gerhard-Domagk-Straße 3, 53121 Bonn, Germany.
Holze J; Pharmacology & Toxicology Section, Institute of Pharmacy, University of Bonn, Gerhard-Domagk-Straße 3, 53121 Bonn, Germany.
Klöckner J; Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.
Balkow A; Pharmacology & Toxicology Section, Institute of Pharmacy, University of Bonn, Gerhard-Domagk-Straße 3, 53121 Bonn, Germany.
Klause AS; Pharmacology & Toxicology Section, Institute of Pharmacy, University of Bonn, Gerhard-Domagk-Straße 3, 53121 Bonn, Germany.
Schmitz AL; Molecular-, Cellular-, and Pharmacobiology Section, Institute of Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.
De Amici M; Dipartimento di Scienze Farmaceutiche, Sezione di Chimica Farmaceutica 'Pietro Pratesi', Università degli Studi di Milano, via L. Mangiagalli 25, 20133 Milan, Italy.
Kostenis E; Molecular-, Cellular-, and Pharmacobiology Section, Institute of Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.
Tränkle C; Pharmacology & Toxicology Section, Institute of Pharmacy, University of Bonn, Gerhard-Domagk-Straße 3, 53121 Bonn, Germany.
Holzgrabe U; Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.
Mohr K; Pharmacology & Toxicology Section, Institute of Pharmacy, University of Bonn, Gerhard-Domagk-Straße 3, 53121 Bonn, Germany. Electronic address: .
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Źródło:
Biochemical pharmacology [Biochem Pharmacol] 2014 Aug 01; Vol. 90 (3), pp. 307-19. Date of Electronic Publication: 2014 May 23.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Models, Biological*
Isoxazoles/*pharmacology
Muscarinic Agonists/*pharmacology
Quaternary Ammonium Compounds/*pharmacology
Receptors, Muscarinic/*metabolism
Allosteric Regulation ; Animals ; CHO Cells ; Cell Membrane/drug effects ; Cell Membrane/metabolism ; Cricetulus ; Drug Inverse Agonism ; Drug Stability ; GTP-Binding Protein alpha Subunits, Gi-Go/metabolism ; Humans ; Isoxazoles/agonists ; Isoxazoles/chemistry ; Kinetics ; Ligands ; Muscarinic Agonists/chemistry ; N-Methylscopolamine/agonists ; N-Methylscopolamine/chemistry ; N-Methylscopolamine/pharmacology ; Protein Conformation/drug effects ; Quaternary Ammonium Compounds/agonists ; Quaternary Ammonium Compounds/chemistry ; Radioligand Assay ; Receptor, Muscarinic M2/agonists ; Receptor, Muscarinic M2/genetics ; Receptor, Muscarinic M2/metabolism ; Receptor, Muscarinic M4/agonists ; Receptor, Muscarinic M4/genetics ; Receptor, Muscarinic M4/metabolism ; Receptors, Muscarinic/chemistry ; Receptors, Muscarinic/genetics ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism ; Tritium
Czasopismo naukowe
Szczegóły
Tytuł:
M2 Subtype preferring dibenzodiazepinone-type muscarinic receptor ligands: Effect of chemical homo-dimerization on orthosteric (and allosteric?) binding.
Autorzy:
Keller M; Department of Pharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Universitätsstr. 31, D-93053 Regensburg, Germany; School of Chemistry, University of New South Wales, UNSW Sydney NSW 2052, Australia. Electronic address: .
Tränkle C; Department of Pharmacology and Toxicology, Institute of Pharmacy, University of Bonn, Gerhard-Domagk-Straße 3, D-53121 Bonn, Germany.
She X; Department of Pharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Universitätsstr. 31, D-93053 Regensburg, Germany.
Pegoli A; Department of Pharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Universitätsstr. 31, D-93053 Regensburg, Germany.
Bernhardt G; Department of Pharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Universitätsstr. 31, D-93053 Regensburg, Germany.
Buschauer A; Department of Pharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Universitätsstr. 31, D-93053 Regensburg, Germany.
Read RW; School of Chemistry, University of New South Wales, UNSW Sydney NSW 2052, Australia. Electronic address: .
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Źródło:
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2015 Jul 15; Vol. 23 (14), pp. 3970-90. Date of Electronic Publication: 2015 Jan 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Structure-Activity Relationship*
Benzodiazepinones/*chemistry
Receptor, Muscarinic M2/*metabolism
Allosteric Site ; Animals ; Benzodiazepinones/chemical synthesis ; Benzodiazepinones/metabolism ; CHO Cells/drug effects ; Chemistry Techniques, Synthetic ; Cricetulus ; Dimerization ; Dose-Response Relationship, Drug ; Humans ; Inhibitory Concentration 50 ; Ligands ; N-Methylscopolamine/metabolism ; Piperidines/chemistry ; Radioligand Assay ; Receptor, Muscarinic M2/genetics
Czasopismo naukowe
Szczegóły
Tytuł:
Functional and biochemical characteristics of urinary bladder muscarinic receptors in long-term alloxan diabetic rats.
Autorzy:
Rocha JN; Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
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Źródło:
Einstein (Sao Paulo, Brazil) [Einstein (Sao Paulo)] 2015 Jul-Sep; Vol. 13 (3), pp. 404-9.
Typ publikacji:
Journal Article
MeSH Terms:
Diabetes Mellitus, Experimental/*metabolism
Receptors, Muscarinic/*metabolism
Urinary Bladder/*metabolism
Alloxan/administration & dosage ; Animals ; Bethanechol/administration & dosage ; Diabetes Mellitus, Experimental/chemically induced ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Male ; Muscle Contraction/drug effects ; Muscle Contraction/physiology ; N-Methylscopolamine/administration & dosage ; Rats, Wistar ; Receptors, Muscarinic/drug effects ; Time Factors ; Urinary Bladder/drug effects ; Urinary Bladder/physiopathology ; Urination/drug effects ; Urination/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Low vagally-mediated heart rate variability and increased susceptibility to ventricular arrhythmias in rats bred for high anxiety.
Autorzy:
Carnevali L; Department of Neuroscience, University of Parma, Italy. Electronic address: .
Trombini M; Department of Neuroscience, University of Parma, Italy.
Graiani G; Department of Clinical and Experimental Medicine, University of Parma, Italy.
Madeddu D; Department of Clinical and Experimental Medicine, University of Parma, Italy.
Quaini F; Department of Clinical and Experimental Medicine, University of Parma, Italy.
Landgraf R; Max Planck Institute of Psychiatry, Munich, Germany.
Neumann ID; Department of Behavioural and Molecular Neurobiology, University of Regensburg, Germany.
Nalivaiko E; School of Biomedical Sciences and Pharmacy, University of Newcastle, New South Wales, Australia.
Sgoifo A; Department of Neuroscience, University of Parma, Italy.
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Źródło:
Physiology & behavior [Physiol Behav] 2014 Apr 10; Vol. 128, pp. 16-25. Date of Electronic Publication: 2014 Feb 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Anxiety/*complications
Arrhythmias, Cardiac/*etiology
Heart Rate/*physiology
Adrenergic beta-1 Receptor Antagonists/pharmacology ; Adrenergic beta-Agonists/pharmacology ; Animals ; Anxiety/physiopathology ; Arrhythmias, Cardiac/physiopathology ; Atenolol/pharmacology ; Electrocardiography ; Heart Rate/drug effects ; Isoproterenol/pharmacology ; Male ; Muscarinic Antagonists/pharmacology ; N-Methylscopolamine/pharmacology ; Rats ; Rats, Inbred Strains/physiology ; Rats, Wistar ; Vagus Nerve/drug effects ; Vagus Nerve/physiology ; Vagus Nerve Stimulation
Czasopismo naukowe
Szczegóły
Tytuł:
Long-term activation upon brief exposure to xanomleline is unique to M1 and M4 subtypes of muscarinic acetylcholine receptors.
Autorzy:
Šantrůčková E; Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Minneapolis, United States of America.
Doležal V; Institute of Physiology Academy of Sciences of the Czech Republic, Prague, Czech Republic.
El-Fakahany EE; Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Minneapolis, United States of America.
Jakubík J; Institute of Physiology Academy of Sciences of the Czech Republic, Prague, Czech Republic.
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Źródło:
PloS one [PLoS One] 2014 Feb 18; Vol. 9 (2), pp. e88910. Date of Electronic Publication: 2014 Feb 18 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Pyridines/*pharmacology
Receptor, Muscarinic M1/*agonists
Receptor, Muscarinic M1/*metabolism
Receptor, Muscarinic M4/*agonists
Receptor, Muscarinic M4/*metabolism
Thiadiazoles/*pharmacology
Animals ; Binding Sites/drug effects ; CHO Cells ; Calcium/metabolism ; Cell Membrane/drug effects ; Cell Membrane/metabolism ; Cricetinae ; Cricetulus ; Cyclic AMP/metabolism ; Extracellular Space/drug effects ; Extracellular Space/metabolism ; Humans ; Intracellular Space/drug effects ; Intracellular Space/metabolism ; Kinetics ; N-Methylscopolamine/pharmacology ; Receptor, Muscarinic M1/antagonists & inhibitors ; Receptor, Muscarinic M4/antagonists & inhibitors ; Time Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 270

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