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Wyszukujesz frazę ""N-Myc Proto-Oncogene Protein"" wg kryterium: Temat


Tytuł :
LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors.
Autorzy :
Tao T; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215.
Shi H; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215.
Mariani L; Department of Medicine, Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.
Abraham BJ; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105.
Durbin AD; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215.; Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.; Broad Institute, Cambridge, MA 02142.
Zimmerman MW; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215.
Powers JT; Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.
Missios P; Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.
Ross KN; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215.
Perez-Atayde AR; Department of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.
Bulyk ML; Department of Medicine, Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115; .; Broad Institute, Cambridge, MA 02142.; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.
Young RA; Whitehead Institute for Biomedical Research, Cambridge, MA 02142; .; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142.
Daley GQ; Stem Cell Program, Division of Hematology/Oncology, Manton Center for Orphan Disease Research, Boston Children's Hospital and Dana-Farber Cancer Institute, Boston, MA 02115; .; Department of Biological Chemistry and Molecular Pharmacology, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115.; Harvard Stem Cell Institute, Cambridge, MA 02138.
Look AT; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Jul 14; Vol. 117 (28), pp. 16516-16526. Date of Electronic Publication: 2020 Jun 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
N-Myc Proto-Oncogene Protein/*metabolism
Neuroblastoma/*metabolism
RNA-Binding Proteins/*metabolism
Trans-Activators/*metabolism
Animals ; Animals, Genetically Modified ; Cell Movement ; Gene Expression Regulation, Neoplastic ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; N-Myc Proto-Oncogene Protein/genetics ; Neuroblastoma/genetics ; Neuroblastoma/physiopathology ; Protein Binding ; RNA-Binding Proteins/genetics ; Trans-Activators/genetics ; Zebrafish
Czasopismo naukowe
Tytuł :
The PLAGL2/MYCN/miR-506-3p interplay regulates neuroblastoma cell fate and associates with neuroblastoma progression.
Autorzy :
Zhao Z; Department of Chemistry and Biochemistry, Texas State University, 601 University Drive, San Marcos, TX, 78666, USA.
Shelton SD; Department of Chemistry and Biochemistry, Texas State University, 601 University Drive, San Marcos, TX, 78666, USA.
Oviedo A; Department of Chemistry and Biochemistry, Texas State University, 601 University Drive, San Marcos, TX, 78666, USA.
Baker AL; Department of Chemistry and Biochemistry, Texas State University, 601 University Drive, San Marcos, TX, 78666, USA.
Bryant CP; Department of Chemistry and Biochemistry, Texas State University, 601 University Drive, San Marcos, TX, 78666, USA.
Omidvarnia S; Department of Chemistry and Biochemistry, Texas State University, 601 University Drive, San Marcos, TX, 78666, USA.
Du L; Department of Chemistry and Biochemistry, Texas State University, 601 University Drive, San Marcos, TX, 78666, USA. .
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Źródło :
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2020 Feb 22; Vol. 39 (1), pp. 41. Date of Electronic Publication: 2020 Feb 22.
Typ publikacji :
Journal Article
MeSH Terms :
DNA-Binding Proteins/*genetics
MicroRNAs/*genetics
N-Myc Proto-Oncogene Protein/*genetics
Neuroblastoma/*genetics
RNA-Binding Proteins/*genetics
Transcription Factors/*genetics
3' Untranslated Regions ; Cell Differentiation/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; DNA-Binding Proteins/metabolism ; Disease Progression ; Gene Expression Regulation, Neoplastic ; Humans ; N-Myc Proto-Oncogene Protein/metabolism ; Neuroblastoma/metabolism ; Neuroblastoma/mortality ; Promoter Regions, Genetic ; RNA-Binding Proteins/metabolism ; Survival Analysis ; Transcription Factors/metabolism ; Tretinoin/pharmacology
Czasopismo naukowe
Tytuł :
MYCN amplification and ATRX mutations are incompatible in neuroblastoma.
Autorzy :
Zeineldin M; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Federico S; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Chen X; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.; St. Jude Children's Research Hospital-Washington University Pediatric Cancer Genome Project, St. Louis, MO, USA.
Fan Y; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Xu B; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Stewart E; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Zhou X; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Jeon J; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Griffiths L; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Nguyen R; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Norrie J; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Easton J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Mulder H; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Yergeau D; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Liu Y; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Wu J; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Van Ryn C; Children's Oncology Group Statistics and Data Center, Department of Biostatistics, University of Florida, Gainesville, FlL, 32607, USA.
Naranjo A; Children's Oncology Group Statistics and Data Center, Department of Biostatistics, University of Florida, Gainesville, FlL, 32607, USA.
Hogarty MD; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Kamiński MM; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Valentine M; Cytogenetics Shared Resource, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Pruett-Miller SM; Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Pappo A; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Zhang J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Clay MR; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Bahrami A; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Vogel P; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Lee S; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Shelat A; Department of Chemical Biology and Therapeutics St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Sarthy JF; Basic Science Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
Meers MP; Basic Science Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
George RE; Department of Hematology/Oncology, Dana Farber Cancer Institute, Boston, MA, 02215, USA.
Mardis ER; The Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, 43205, USA.
Wilson RK; The Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, 43205, USA.
Henikoff S; Basic Science Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, 20815, USA.
Downing JR; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Dyer MA; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA. .; St. Jude Children's Research Hospital-Washington University Pediatric Cancer Genome Project, St. Louis, MO, USA. .; Howard Hughes Medical Institute, Chevy Chase, MD, 20815, USA. .; Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Feb 14; Vol. 11 (1), pp. 913. Date of Electronic Publication: 2020 Feb 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
N-Myc Proto-Oncogene Protein/*genetics
Neuroblastoma/*metabolism
X-linked Nuclear Protein/*genetics
Animals ; Child, Preschool ; Cohort Studies ; Female ; Gene Amplification ; Humans ; Infant ; Male ; Mice ; Mitochondria/genetics ; Mitochondria/metabolism ; Mutation ; N-Myc Proto-Oncogene Protein/metabolism ; Neuroblastoma/genetics ; Reactive Oxygen Species/metabolism ; X-linked Nuclear Protein/metabolism
Czasopismo naukowe
Tytuł :
Lipid desaturation-associated endoplasmic reticulum stress regulates MYCN gene expression in hepatocellular carcinoma cells.
Autorzy :
Qin XY; Liver Cancer Prevention Research Unit, RIKEN Cluster for Pioneering Research, Wako, Saitama, 351-0198, Japan. .
Su T; Liver Cancer Prevention Research Unit, RIKEN Cluster for Pioneering Research, Wako, Saitama, 351-0198, Japan.; Department of Intensive Care Unit, the Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, 210008, China.
Yu W; Department of Intensive Care Unit, the Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, 210008, China.
Kojima S; Liver Cancer Prevention Research Unit, RIKEN Cluster for Pioneering Research, Wako, Saitama, 351-0198, Japan.
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Źródło :
Cell death & disease [Cell Death Dis] 2020 Jan 27; Vol. 11 (1), pp. 66. Date of Electronic Publication: 2020 Jan 27.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Hepatocellular/*metabolism
Endoplasmic Reticulum Stress/*genetics
Fatty Acids, Unsaturated/*metabolism
Liver Neoplasms/*metabolism
N-Myc Proto-Oncogene Protein/*metabolism
Activating Transcription Factor 3/genetics ; Activating Transcription Factor 3/metabolism ; Carcinoma, Hepatocellular/genetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Chromatography, Liquid ; Endoplasmic Reticulum Stress/drug effects ; Fatty Acids, Unsaturated/chemistry ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Liver Neoplasms/genetics ; Magnetic Resonance Spectroscopy ; Mass Spectrometry ; Metabolome ; N-Myc Proto-Oncogene Protein/genetics ; Neoplastic Stem Cells/metabolism ; Organoids/drug effects ; Organoids/metabolism ; RNA, Small Interfering ; RNA-Seq ; Signal Transduction/drug effects ; Signal Transduction/genetics ; Stearoyl-CoA Desaturase/antagonists & inhibitors ; Tretinoin/analogs & derivatives ; Tretinoin/metabolism ; Tretinoin/pharmacology
Czasopismo naukowe
Tytuł :
A Novel MYCN-Specific Antigene Oligonucleotide Deregulates Mitochondria and Inhibits Tumor Growth in MYCN-Amplified Neuroblastoma.
Autorzy :
Montemurro L; Interdepartmental Center for Cancer Research, University of Bologna, Bologna, Italy.
Raieli S; R&D Department, BIOGENERA SpA, Bologna, Italy.
Angelucci S; Interdepartmental Center for Cancer Research, University of Bologna, Bologna, Italy.
Bartolucci D; Interdepartmental Center for Cancer Research, University of Bologna, Bologna, Italy.
Amadesi C; R&D Department, BIOGENERA SpA, Bologna, Italy.
Lampis S; R&D Department, BIOGENERA SpA, Bologna, Italy.
Scardovi AL; R&D Department, BIOGENERA SpA, Bologna, Italy.
Venturelli L; R&D Department, BIOGENERA SpA, Bologna, Italy.
Nieddu G; R&D Department, BIOGENERA SpA, Bologna, Italy.
Cerisoli L; R&D Department, BIOGENERA SpA, Bologna, Italy.
Fischer M; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Teti G; Department of Biomedical and Neuromotor Sciences-DBNS, University of Bologna, Bologna, Italy.
Falconi M; Department of Biomedical and Neuromotor Sciences-DBNS, University of Bologna, Bologna, Italy.
Pession A; Interdepartmental Center for Cancer Research, University of Bologna, Bologna, Italy.
Hrelia P; Department of Pharmacy and Biotechnologies, University of Bologna, Bologna, Italy.
Tonelli R; Department of Pharmacy and Biotechnologies, University of Bologna, Bologna, Italy. .
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Źródło :
Cancer research [Cancer Res] 2019 Dec 15; Vol. 79 (24), pp. 6166-6177. Date of Electronic Publication: 2019 Oct 15.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic/*drug effects
Mitochondria/*drug effects
N-Myc Proto-Oncogene Protein/*metabolism
Neuroblastoma/*pathology
Peptide Nucleic Acids/*pharmacology
Adolescent ; Adult ; Animals ; Apoptosis/drug effects ; Cell Differentiation/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Child ; Child, Preschool ; Female ; HSP90 Heat-Shock Proteins/metabolism ; Humans ; Infant ; Infant, Newborn ; Kaplan-Meier Estimate ; Male ; Mice ; Mitochondria/metabolism ; Mitochondria/pathology ; Mitophagy/drug effects ; N-Myc Proto-Oncogene Protein/antagonists & inhibitors ; N-Myc Proto-Oncogene Protein/genetics ; Neuroblastoma/drug therapy ; Neuroblastoma/genetics ; Neuroblastoma/mortality ; Peptide Nucleic Acids/genetics ; Peptide Nucleic Acids/therapeutic use ; Prognosis ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Reactive Oxygen Species/metabolism ; Xenograft Model Antitumor Assays ; Young Adult
Czasopismo naukowe
Tytuł :
BET and Aurora Kinase A inhibitors synergize against MYCN-positive human glioblastoma cells.
Autorzy :
Čančer M; Department of Immunology, Genetics and Pathology, Science For Life Laboratory, Uppsala University, Uppsala, Sweden.
Drews LF; Department of Immunology, Genetics and Pathology, Science For Life Laboratory, Uppsala University, Uppsala, Sweden.
Bengtsson J; Department of Immunology, Genetics and Pathology, Science For Life Laboratory, Uppsala University, Uppsala, Sweden.
Bolin S; Department of Immunology, Genetics and Pathology, Science For Life Laboratory, Uppsala University, Uppsala, Sweden.
Rosén G; Department of Immunology, Genetics and Pathology, Science For Life Laboratory, Uppsala University, Uppsala, Sweden.
Westermark B; Department of Immunology, Genetics and Pathology, Science For Life Laboratory, Uppsala University, Uppsala, Sweden.
Nelander S; Department of Immunology, Genetics and Pathology, Science For Life Laboratory, Uppsala University, Uppsala, Sweden.
Forsberg-Nilsson K; Department of Immunology, Genetics and Pathology, Science For Life Laboratory, Uppsala University, Uppsala, Sweden.
Uhrbom L; Department of Immunology, Genetics and Pathology, Science For Life Laboratory, Uppsala University, Uppsala, Sweden.
Weishaupt H; Department of Immunology, Genetics and Pathology, Science For Life Laboratory, Uppsala University, Uppsala, Sweden.
Swartling FJ; Department of Immunology, Genetics and Pathology, Science For Life Laboratory, Uppsala University, Uppsala, Sweden. .
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Źródło :
Cell death & disease [Cell Death Dis] 2019 Nov 21; Vol. 10 (12), pp. 881. Date of Electronic Publication: 2019 Nov 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Aurora Kinase A/*antagonists & inhibitors
Brain Neoplasms/*drug therapy
N-Myc Proto-Oncogene Protein/*genetics
Proteins/*antagonists & inhibitors
Adult ; Aged ; Azepines/administration & dosage ; Azepines/pharmacology ; Brain Neoplasms/genetics ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Drug Synergism ; Female ; Glioblastoma/drug therapy ; Humans ; Male ; Middle Aged ; N-Myc Proto-Oncogene Protein/biosynthesis ; N-Myc Proto-Oncogene Protein/metabolism ; Temozolomide/administration & dosage ; Temozolomide/pharmacology ; Triazoles/administration & dosage ; Triazoles/pharmacology
Czasopismo naukowe
Tytuł :
Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma.
Autorzy :
Helmsauer K; Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Valieva ME; RG Development & Disease, Max Planck Institute for Molecular Genetics, Ihnestraße 63-73, 14195, Berlin, Germany.; Institute for Medical and Human Genetics, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Ali S; RG Development & Disease, Max Planck Institute for Molecular Genetics, Ihnestraße 63-73, 14195, Berlin, Germany.; Institute for Medical and Human Genetics, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.; Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Chamorro González R; Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Schöpflin R; RG Development & Disease, Max Planck Institute for Molecular Genetics, Ihnestraße 63-73, 14195, Berlin, Germany.; Institute for Medical and Human Genetics, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Röefzaad C; Experimental and Clinical Research Center (ECRC), Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Lindenberger Weg 80, 13125, Berlin, Germany.
Bei Y; Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Dorado Garcia H; Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Rodriguez-Fos E; Barcelona Supercomputing Center, Joint BSC-CRG-IRB Research Program in Computational Biology, Jordi Girona 29, 08034, Barcelona, Spain.
Puiggròs M; Barcelona Supercomputing Center, Joint BSC-CRG-IRB Research Program in Computational Biology, Jordi Girona 29, 08034, Barcelona, Spain.
Kasack K; German Cancer Consortium (DKTK), partner site Berlin, and German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.
Haase K; Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Keskeny C; Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.; German Cancer Consortium (DKTK), partner site Berlin, and German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.
Chen CY; Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Kuschel LP; Department of Neurology with Experimental Neurology, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Euskirchen P; German Cancer Consortium (DKTK), partner site Berlin, and German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.; Department of Neurology with Experimental Neurology, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.; Berlin Institute of Health, Anna-Louisa-Karsch-Str. 2, 10178, Berlin, Germany.
Heinrich V; Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Ihnestraße 63-73, 14195, Berlin, Germany.
Robson MI; RG Development & Disease, Max Planck Institute for Molecular Genetics, Ihnestraße 63-73, 14195, Berlin, Germany.
Rosswog C; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Kerpener Straße 62, 50937, Köln, Germany.
Toedling J; Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Szymansky A; Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Hertwig F; Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Fischer M; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Kerpener Straße 62, 50937, Köln, Germany.
Torrents D; Barcelona Supercomputing Center, Joint BSC-CRG-IRB Research Program in Computational Biology, Jordi Girona 29, 08034, Barcelona, Spain.; Institució Catalana de Recerca i Estudis Avançats (ICREA), Passeig Lluís Companys 23, 08010, Barcelona, Spain.
Eggert A; Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.; German Cancer Consortium (DKTK), partner site Berlin, and German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.; Berlin Institute of Health, Anna-Louisa-Karsch-Str. 2, 10178, Berlin, Germany.
Schulte JH; Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.; German Cancer Consortium (DKTK), partner site Berlin, and German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.; Berlin Institute of Health, Anna-Louisa-Karsch-Str. 2, 10178, Berlin, Germany.
Mundlos S; RG Development & Disease, Max Planck Institute for Molecular Genetics, Ihnestraße 63-73, 14195, Berlin, Germany.; Institute for Medical and Human Genetics, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.; Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Henssen AG; Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany. .; Experimental and Clinical Research Center (ECRC), Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Lindenberger Weg 80, 13125, Berlin, Germany. .; German Cancer Consortium (DKTK), partner site Berlin, and German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. .; Berlin Institute of Health, Anna-Louisa-Karsch-Str. 2, 10178, Berlin, Germany. .
Koche RP; Berlin Institute of Health, Anna-Louisa-Karsch-Str. 2, 10178, Berlin, Germany. .; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, 430 East 67th Street, New York, NY, 10065, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 16; Vol. 11 (1), pp. 5823. Date of Electronic Publication: 2020 Nov 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromosomes, Human/*genetics
Enhancer Elements, Genetic/*genetics
N-Myc Proto-Oncogene Protein/*genetics
Neuroblastoma/*genetics
Acetylation ; Base Sequence ; Cell Line, Tumor ; DNA Methylation/genetics ; DNA, Circular/genetics ; Epigenesis, Genetic ; Histones/metabolism ; Humans ; Kaplan-Meier Estimate ; Lysine/metabolism ; Nanopore Sequencing
Czasopismo naukowe
Tytuł :
MYCN and PRC1 cooperatively repress docosahexaenoic acid synthesis in neuroblastoma via ELOVL2.
Autorzy :
Ding Y; Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200011, China.; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, 200011, China.
Yang J; Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200011, China.; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, 200011, China.
Ma Y; Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200011, China.; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, 200011, China.
Yao T; Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200011, China.; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, 200011, China.
Chen X; Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200011, China.; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, 200011, China.
Ge S; Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200011, China. .; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, 200011, China. .
Wang L; Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200011, China. .; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, 200011, China. .
Fan X; Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200011, China. .; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, 200011, China. .
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Źródło :
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2019 Dec 19; Vol. 38 (1), pp. 498. Date of Electronic Publication: 2019 Dec 19.
Typ publikacji :
Journal Article
MeSH Terms :
Docosahexaenoic Acids/*biosynthesis
Fatty Acid Elongases/*genetics
N-Myc Proto-Oncogene Protein/*metabolism
Neuroblastoma/*genetics
Neuroblastoma/*metabolism
Polycomb Repressive Complex 1/*metabolism
Animals ; Cell Line, Tumor ; Disease Models, Animal ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Heterografts ; Histones/metabolism ; Humans ; Mice ; Models, Biological ; N-Myc Proto-Oncogene Protein/genetics ; Neuroblastoma/mortality ; Neuroblastoma/pathology ; Polycomb Repressive Complex 1/genetics
Czasopismo naukowe
Tytuł :
Human bone marrow-derived mesenchymal stem cell-secreted exosomes overexpressing microRNA-34a ameliorate glioblastoma development via down-regulating MYCN.
Autorzy :
Wang B; Department of Neurosurgery, Henan Province People's Hospital, Zhengzhou University, No. 7, Weiwu Road, Zhengzhou, 450003, Henan Province, People's Republic of China.; Department of Neurosurgery, People's Hospital Affiliated with Zhengzhou University, No. 7, Weiwu Road, Zhengzhou, 450003, Henan Province, People's Republic of China.; Department of Neurosurgery, People's Hospital Affiliated with Medical college of Henan University, No. 7, Weiwu Road, Zhengzhou, 450003, Henan Province, People's Republic of China.
Wu ZH; Department of Neurosurgery, Henan Province People's Hospital, Zhengzhou University, No. 7, Weiwu Road, Zhengzhou, 450003, Henan Province, People's Republic of China.; Department of Neurosurgery, People's Hospital Affiliated with Zhengzhou University, No. 7, Weiwu Road, Zhengzhou, 450003, Henan Province, People's Republic of China.; Department of Neurosurgery, People's Hospital Affiliated with Medical college of Henan University, No. 7, Weiwu Road, Zhengzhou, 450003, Henan Province, People's Republic of China.
Lou PY; Department of Neurosurgery, Henan Province People's Hospital, Zhengzhou University, No. 7, Weiwu Road, Zhengzhou, 450003, Henan Province, People's Republic of China.; Department of Neurosurgery, People's Hospital Affiliated with Zhengzhou University, No. 7, Weiwu Road, Zhengzhou, 450003, Henan Province, People's Republic of China.; Department of Neurosurgery, People's Hospital Affiliated with Medical college of Henan University, No. 7, Weiwu Road, Zhengzhou, 450003, Henan Province, People's Republic of China.
Chai C; Department of Ophthalmology, Henan Province People's Hospital, Zhengzhou University, Zhengzhou, 450003, People's Republic of China.
Han SY; Center for Translational Medicine, Henan Province People's Hospital, Zhengzhou University, Zhengzhou, 450003, People's Republic of China.
Ning JF; Department of Neurosurgery, University of Minnesota, Minneapolis, 55455, USA.
Li M; Department of Neurosurgery, Henan Province People's Hospital, Zhengzhou University, No. 7, Weiwu Road, Zhengzhou, 450003, Henan Province, People's Republic of China. .; Department of Neurosurgery, People's Hospital Affiliated with Zhengzhou University, No. 7, Weiwu Road, Zhengzhou, 450003, Henan Province, People's Republic of China. .; Department of Neurosurgery, People's Hospital Affiliated with Medical college of Henan University, No. 7, Weiwu Road, Zhengzhou, 450003, Henan Province, People's Republic of China. .
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Źródło :
Cellular oncology (Dordrecht) [Cell Oncol (Dordr)] 2019 Dec; Vol. 42 (6), pp. 783-799. Date of Electronic Publication: 2019 Jul 22.
Typ publikacji :
Journal Article
MeSH Terms :
Down-Regulation*
Exosomes/*metabolism
Glioblastoma/*therapy
Mesenchymal Stem Cells/*metabolism
MicroRNAs/*metabolism
N-Myc Proto-Oncogene Protein/*genetics
Animals ; Base Sequence ; Cell Differentiation/drug effects ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Drug Resistance, Neoplasm/drug effects ; Exosomes/drug effects ; Exosomes/ultrastructure ; Gene Expression Regulation, Neoplastic/drug effects ; Glioblastoma/genetics ; Glioblastoma/pathology ; Humans ; Male ; Mesenchymal Stem Cells/drug effects ; Mice, Inbred BALB C ; Mice, Nude ; MicroRNAs/genetics ; Models, Biological ; N-Myc Proto-Oncogene Protein/metabolism ; Neoplasm Invasiveness ; Temozolomide/pharmacology ; Temozolomide/therapeutic use
Czasopismo naukowe
Tytuł :
Quantitative Proteomics of Th-MYCN Transgenic Mice Reveals Aurora Kinase Inhibitor Altered Metabolic Pathways and Enhanced ACADM To Suppress Neuroblastoma Progression.
Autorzy :
Hsieh CH
Cheung CHY
Liu YL; Department of Pediatrics , Taipei Medical University Hospital , Taipei 110 , Taiwan.
Hou CL
Hsu CL; Department of Medical Research , National Taiwan University Hospital , Taipei 100 , Taiwan.
Huang CT
Yang TS; Department of Surgery , National Taiwan University Hospital and College of Medicine National Taiwan University , Taipei 100 , Taiwan.
Chen SF; Department of Chemistry , National Taiwan Normal University , Taipei 116 , Taiwan.
Chen CN; Department of Surgery , National Taiwan University Hospital and College of Medicine National Taiwan University , Taipei 100 , Taiwan.
Hsu WM; Department of Surgery , National Taiwan University Hospital and College of Medicine National Taiwan University , Taipei 100 , Taiwan.
Huang HC; Institute of Biomedical Informatics , National Yang-Ming University , Taipei 112 , Taiwan.
Juan HF
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Źródło :
Journal of proteome research [J Proteome Res] 2019 Nov 01; Vol. 18 (11), pp. 3850-3866. Date of Electronic Publication: 2019 Oct 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acyl-CoA Dehydrogenase/*metabolism
Metabolic Networks and Pathways/*drug effects
N-Myc Proto-Oncogene Protein/*metabolism
Neuroblastoma/*metabolism
Protein Kinase Inhibitors/*pharmacology
Proteomics/*methods
Acyl-CoA Dehydrogenase/genetics ; Animals ; Aurora Kinases/antagonists & inhibitors ; Aurora Kinases/genetics ; Aurora Kinases/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Disease Progression ; Gene Expression Profiling/methods ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Metabolic Networks and Pathways/genetics ; Mice, 129 Strain ; Mice, Transgenic ; N-Myc Proto-Oncogene Protein/genetics ; Neuroblastoma/drug therapy ; Neuroblastoma/genetics ; Piperazines/pharmacology ; Survival Analysis
Czasopismo naukowe
Tytuł :
Differential Clinical Significance of Neurotrophin-3 Expression according to MYCN Amplification and TrkC Expression in Neuroblastoma.
Autorzy :
Seo E; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Kim JS; Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.; Department of Health Sciences and Technology, Sungkyunkwan University, Samsung Advanced Institute for Health Sciences & Technology, Seoul, Korea.
Ma YE; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Cho HW; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Ju HY; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Lee SH; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Lee JW; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Yoo KH; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Sung KW; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. .
Koo HH; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
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Źródło :
Journal of Korean medical science [J Korean Med Sci] 2019 Oct 14; Vol. 34 (39), pp. e254. Date of Electronic Publication: 2019 Oct 14.
Typ publikacji :
Journal Article
MeSH Terms :
N-Myc Proto-Oncogene Protein/*metabolism
Neuroblastoma/*diagnosis
Neurotrophin 3/*metabolism
Receptor, trkC/*metabolism
Adolescent ; Antineoplastic Agents/therapeutic use ; Child ; Child, Preschool ; Female ; Humans ; Immunohistochemistry ; Infant ; Infant, Newborn ; Male ; N-Myc Proto-Oncogene Protein/genetics ; Neoplasm Staging ; Neuroblastoma/drug therapy ; Neuroblastoma/pathology ; Neurotrophin 3/genetics ; Prognosis ; Progression-Free Survival ; Proportional Hazards Models ; Real-Time Polymerase Chain Reaction ; Receptor, trkC/genetics
Czasopismo naukowe
Tytuł :
A combined experimental and computational study on peptide nucleic acid (PNA) analogues of tumor suppressive miRNA-34a.
Autorzy :
Piacenti V; RCSI, Dept. of Pharmaceutical & Medicinal Chemistry, 123 St Stephen's Green, Dublin 2, Ireland.
Langella E; National Research Council (CNR)-IBB, via Mezzocannone 16, 80134 Naples, Italy.
Autiero I; National Research Council (CNR)-IBB, via Mezzocannone 16, 80134 Naples, Italy.
Nolan JC; RCSI, Dept. of Cancer Genetics, York Street, Dublin 2, Ireland.
Piskareva O; RCSI, Dept. of Cancer Genetics, York Street, Dublin 2, Ireland.
Adamo MFA; RCSI, Dept. of Pharmaceutical & Medicinal Chemistry, 123 St Stephen's Green, Dublin 2, Ireland.
Saviano M; National Research Council (CNR)-IC, via G. Amendola 122/O, 70126 Bari, Italy.
Moccia M; National Research Council (CNR)-IC, via G. Amendola 122/O, 70126 Bari, Italy. Electronic address: .
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2019 Oct; Vol. 91, pp. 103165. Date of Electronic Publication: 2019 Aug 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Proliferation*
MicroRNAs/*genetics
N-Myc Proto-Oncogene Protein/*antagonists & inhibitors
Neuroblastoma/*drug therapy
Peptide Nucleic Acids/*pharmacology
RNA, Messenger/*antagonists & inhibitors
Computational Chemistry ; Humans ; Microscopy, Confocal ; Molecular Dynamics Simulation ; N-Myc Proto-Oncogene Protein/genetics ; Neuroblastoma/genetics ; Neuroblastoma/pathology ; Peptide Nucleic Acids/chemical synthesis ; RNA, Messenger/genetics ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis.
Autorzy :
Huang M; Department of Neurology and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.
Tailor J; Wellcome Trust-MRC Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK; Institute of Cancer Research, Sutton, London SM2 5NG, UK; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada.
Zhen Q; Department of Neurology and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.
Gillmor AH; Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB, Canada; Charbonneau Cancer Institute, University of Calgary, Calgary, AB, Canada; Alberta Children's Hospital Research Institute, Calgary, AB, Canada.
Miller ML; Department of Neurology and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.
Weishaupt H; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 751 85 Uppsala, Sweden.
Chen J; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Zheng T; Department of Neurology and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.
Nash EK; Department of Neurology and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.
McHenry LK; Department of Neurology and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.
An Z; Department of Neurology and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.
Ye F; Department of Neurology and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.
Takashima Y; Wellcome Trust-MRC Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.
Clarke J; Wellcome Trust-MRC Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.
Ayetey H; Wellcome Trust-MRC Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.
Cavalli FMG; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
Luu B; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
Moriarity BS; Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA; Center for Genome Engineering, University of Minnesota, Minneapolis, MN 55455, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.
Ilkhanizadeh S; Department of Neurology and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.
Chavez L; Hopp-Children's Cancer Center (KiTZ), Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.
Yu C; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.
Kurian KM; Institute of Clinical Neurosciences, Level 1, Learning and Research Building, Southmead Hospital, University of Bristol, Bristol BS10 5NB, UK.
Magnaldo T; Institute for Research on Cancer and Aging, Nice UMR CNRS 7284 INSERM U1081 UNS/UCA, Nice, France.
Sevenet N; Institut Bergonie & INSERM U1218, Universite de Bordeaux, 229 cours de l'Argonne, 33076 Bordeaux Cedex, France.
Koch P; Central Institute of Mental Health, University of Heidelberg/Medical Faculty Mannheim and Hector Institut for Translational Brain Research (HITBR gGmbH), Mannheim, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany.
Pollard SM; MRC Centre for Regenerative Medicine and Cancer Research UK Edinburgh Centre, University of Edinburgh, Edinburgh, UK.
Dirks P; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
Snyder MP; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Largaespada DA; Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA; Center for Genome Engineering, University of Minnesota, Minneapolis, MN 55455, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.
Cho YJ; Division of Pediatric Neurology, Department of Pediatrics, Oregon Health & Science University, Portland, OR, USA; Papé Family Pediatric Research Institute, Department of Pediatrics, Oregon Health & Science University, Portland, OR, USA; Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.
Phillips JJ; Departments of Neurological Surgery and Pathology, University of California, San Francisco, CA 94158, USA.
Swartling FJ; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 751 85 Uppsala, Sweden.
Morrissy AS; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB, Canada; Charbonneau Cancer Institute, University of Calgary, Calgary, AB, Canada; Alberta Children's Hospital Research Institute, Calgary, AB, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
Kool M; Hopp-Children's Cancer Center (KiTZ), Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.
Pfister SM; Hopp-Children's Cancer Center (KiTZ), Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany; Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany.
Taylor MD; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Smith A; Wellcome Trust-MRC Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.
Weiss WA; Department of Neurology and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA; Departments of Pediatrics, Neurosurgery and Brain Tumor Research Center, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: .
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Źródło :
Cell stem cell [Cell Stem Cell] 2019 Sep 05; Vol. 25 (3), pp. 433-446.e7. Date of Electronic Publication: 2019 Jun 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Basal Cell Nevus Syndrome/*genetics
Brain Neoplasms/*genetics
Medulloblastoma/*genetics
N-Myc Proto-Oncogene Protein/*metabolism
Neural Stem Cells/*physiology
Neuroepithelial Cells/*physiology
Pluripotent Stem Cells/*physiology
Animals ; Basal Cell Nevus Syndrome/metabolism ; Basal Cell Nevus Syndrome/pathology ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Carcinogenesis/genetics ; DEAD-box RNA Helicases/genetics ; Disease Models, Animal ; Genetic Engineering ; Genetic Predisposition to Disease ; Humans ; Medulloblastoma/metabolism ; Medulloblastoma/pathology ; Mice ; Mice, SCID ; N-Myc Proto-Oncogene Protein/genetics ; Neoplasm Proteins/genetics ; Patched-1 Receptor/genetics ; Stem Cell Transplantation ; Transplantation, Heterologous
Czasopismo naukowe
Tytuł :
N-Myc-mediated epigenetic reprogramming drives lineage plasticity in advanced prostate cancer.
Autorzy :
Berger A; Department of Pathology and Laboratory Medicine.
Brady NJ; Department of Pathology and Laboratory Medicine.
Bareja R; Caryl and Israel Englander Institute for Precision Medicine, NewYork-Presbyterian Hospital.
Robinson B; Department of Pathology and Laboratory Medicine.; Caryl and Israel Englander Institute for Precision Medicine, NewYork-Presbyterian Hospital.
Conteduca V; Department of Medicine.
Augello MA; Department of Urology, and.
Puca L; Department of Medicine.
Ahmed A; Department of Biochemistry, Weill Cornell Medicine, New York, New York, USA.
Dardenne E; Department of Pathology and Laboratory Medicine.
Lu X; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Hwang I; Department of Pathology and Laboratory Medicine.
Bagadion AM; Department of Pathology and Laboratory Medicine.
Sboner A; Department of Pathology and Laboratory Medicine.; Caryl and Israel Englander Institute for Precision Medicine, NewYork-Presbyterian Hospital.; Department of Physiology and Biophysics, Institute for Computational Biomedicine, and.; Meyer Cancer Center, Weill Cornell Medicine, New York, New York, USA.
Elemento O; Caryl and Israel Englander Institute for Precision Medicine, NewYork-Presbyterian Hospital.; Department of Physiology and Biophysics, Institute for Computational Biomedicine, and.; Meyer Cancer Center, Weill Cornell Medicine, New York, New York, USA.
Paik J; Department of Pathology and Laboratory Medicine.; Meyer Cancer Center, Weill Cornell Medicine, New York, New York, USA.
Yu J; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Barbieri CE; Caryl and Israel Englander Institute for Precision Medicine, NewYork-Presbyterian Hospital.; Department of Urology, and.; Meyer Cancer Center, Weill Cornell Medicine, New York, New York, USA.
Dephoure N; Department of Biochemistry, Weill Cornell Medicine, New York, New York, USA.; Meyer Cancer Center, Weill Cornell Medicine, New York, New York, USA.
Beltran H; Caryl and Israel Englander Institute for Precision Medicine, NewYork-Presbyterian Hospital.; Department of Medicine.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Rickman DS; Department of Pathology and Laboratory Medicine.; Caryl and Israel Englander Institute for Precision Medicine, NewYork-Presbyterian Hospital.; Meyer Cancer Center, Weill Cornell Medicine, New York, New York, USA.
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2019 Jul 01; Vol. 129 (9), pp. 3924-3940. Date of Electronic Publication: 2019 Jul 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Cell Lineage*
Epigenesis, Genetic*
N-Myc Proto-Oncogene Protein/*metabolism
Prostatic Neoplasms/*metabolism
Prostatic Neoplasms, Castration-Resistant/*metabolism
Animals ; Cell Line, Tumor ; Cell Plasticity ; DNA/chemistry ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Mice ; Mice, Transgenic ; N-Myc Proto-Oncogene Protein/genetics ; Neoplasm Transplantation ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Prostatic Neoplasms, Castration-Resistant/genetics ; Receptors, Androgen/genetics ; Signal Transduction ; Transcriptome
Czasopismo naukowe
Tytuł :
Downregulation of PIF1, a potential new target of MYCN, induces apoptosis and inhibits cell migration in neuroblastoma cells.
Autorzy :
Chen B; Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China; Medical Research Center, Liaoning Key Laboratory of Research and Application of Animal Models for Environmental and Metabolic Diseases, Shengjing Hospital of China Medical University, Shenyang, China.
Hua Z; Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China; Medical Research Center, Liaoning Key Laboratory of Research and Application of Animal Models for Environmental and Metabolic Diseases, Shengjing Hospital of China Medical University, Shenyang, China.
Gong B; Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China; Medical Research Center, Liaoning Key Laboratory of Research and Application of Animal Models for Environmental and Metabolic Diseases, Shengjing Hospital of China Medical University, Shenyang, China.
Tan X; Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China; Medical Research Center, Liaoning Key Laboratory of Research and Application of Animal Models for Environmental and Metabolic Diseases, Shengjing Hospital of China Medical University, Shenyang, China.
Zhang S; Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China; Medical Research Center, Liaoning Key Laboratory of Research and Application of Animal Models for Environmental and Metabolic Diseases, Shengjing Hospital of China Medical University, Shenyang, China.
Li Q; Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China; Medical Research Center, Liaoning Key Laboratory of Research and Application of Animal Models for Environmental and Metabolic Diseases, Shengjing Hospital of China Medical University, Shenyang, China.
Chen Y; Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China; Medical Research Center, Liaoning Key Laboratory of Research and Application of Animal Models for Environmental and Metabolic Diseases, Shengjing Hospital of China Medical University, Shenyang, China.
Zhang J; Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China; Medical Research Center, Liaoning Key Laboratory of Research and Application of Animal Models for Environmental and Metabolic Diseases, Shengjing Hospital of China Medical University, Shenyang, China.
Li Z; Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China; Medical Research Center, Liaoning Key Laboratory of Research and Application of Animal Models for Environmental and Metabolic Diseases, Shengjing Hospital of China Medical University, Shenyang, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Sep 01; Vol. 256, pp. 117820. Date of Electronic Publication: 2020 Jun 05.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*genetics
Cell Movement/*genetics
DNA Helicases/*genetics
N-Myc Proto-Oncogene Protein/*genetics
Neuroblastoma/*pathology
Cell Line, Tumor ; Cell Survival/genetics ; Computational Biology ; Down-Regulation ; Gene Expression Regulation, Neoplastic ; Humans ; Neuroblastoma/genetics ; RNA, Messenger/metabolism ; RNA, Small Interfering/genetics ; Up-Regulation
Czasopismo naukowe
Tytuł :
Association of heterogeneous MYCN amplification with clinical features, biological characteristics and outcomes in neuroblastoma: A report from the Children's Oncology Group.
Autorzy :
Campbell K; Dana-Farber / Boston Children's Cancer and Blood Disorders Center and Harvard Medical School, Boston, MA, USA.
Naranjo A; Children's Oncology Group Statistics and Data Center, University of Florida, Gainesville, FL, USA.
Hibbitts E; Children's Oncology Group Statistics and Data Center, University of Florida, Gainesville, FL, USA.
Gastier-Foster JM; Institute for Genomic Medicine, Nationwide Children's Hospital, Departments of Pathology and Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA.
Bagatell R; Department of Pediatrics, Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Irwin MS; Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada.
Shimada H; Department of Pathology, Stanford University, USA.
Hogarty M; Department of Pediatrics, Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Park JR; Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.
DuBois SG; Dana-Farber / Boston Children's Cancer and Blood Disorders Center and Harvard Medical School, Boston, MA, USA. Electronic address: .
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Źródło :
European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2020 Jul; Vol. 133, pp. 112-119. Date of Electronic Publication: 2020 May 31.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Amplification*
N-Myc Proto-Oncogene Protein/*genetics
Neuroblastoma/*diagnosis
Neuroblastoma/*genetics
Child ; Child, Preschool ; Cohort Studies ; Female ; Genetic Association Studies ; Genetic Heterogeneity ; Humans ; Infant ; Male ; Neuroblastoma/mortality ; Prognosis ; Retrospective Studies ; Survival Analysis
Czasopismo naukowe
Tytuł :
Thymidylate synthase inhibitor raltitrexed can induce high levels of DNA damage in MYCN-amplified neuroblastoma cells.
Autorzy :
Yamashita K; Department of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kiyonari S; Department of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Division of Biochemistry, Kitasato University School of Medicine, Sagamihara, Japan.
Tsubota S; Department of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kishida S; Department of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Sakai R; Division of Biochemistry, Kitasato University School of Medicine, Sagamihara, Japan.
Kadomatsu K; Department of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan.
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Źródło :
Cancer science [Cancer Sci] 2020 Jul; Vol. 111 (7), pp. 2431-2439. Date of Electronic Publication: 2020 Jun 10.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Damage*
Gene Amplification*
N-Myc Proto-Oncogene Protein/*genetics
Neuroblastoma/*genetics
Quinazolines/*pharmacology
Thiophenes/*pharmacology
Thymidylate Synthase/*antagonists & inhibitors
Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation ; Dose-Response Relationship, Drug ; Humans ; Metabolic Networks and Pathways ; Neuroblastoma/metabolism
Czasopismo naukowe
Tytuł :
Crocin inhibits proliferation and induces apoptosis through suppressing MYCN expression in retinoblastoma.
Autorzy :
Deng L; Department of TCM Ophthalmology, Jinan Second People's Hospital, Jinan, Shandong, China.
Li J; Department of TCM, Shandong Provincial Western Hospital, Jinan, Shandong, China.
Lu S; Department of Acupuncture, Affiliated Hospital of Shandong University of TCM, Jinan, Shandong, China.
Su Y; Department of TCM Ophthalmology, Jinan Second People's Hospital, Jinan, Shandong, China.
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Źródło :
Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2019 May; Vol. 33 (5), pp. e22292. Date of Electronic Publication: 2019 Jan 23.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Carotenoids/*pharmacology
Cell Proliferation/*drug effects
Gene Expression Regulation, Neoplastic/*drug effects
N-Myc Proto-Oncogene Protein/*biosynthesis
Retinoblastoma/*drug therapy
Cell Line, Tumor ; Drug Screening Assays, Antitumor ; Humans ; N-Myc Proto-Oncogene Protein/antagonists & inhibitors ; Protein Stability/drug effects ; Retinoblastoma/metabolism ; Retinoblastoma/pathology
Czasopismo naukowe
Tytuł :
Targeting excessive MYCN expression using MLN8237 and JQ1 impairs the growth of hepatoblastoma cells.
Autorzy :
Eberherr C; Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, D‑80337 Munich, Germany.
Beck A; Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, D‑80337 Munich, Germany.
Vokuhl C; Institute of Paidopathology, Pediatric Tumor Registry, Christian‑Albrecht's‑University Kiel, D‑24105 Kiel, Germany.
Becker K; Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, D‑80337 Munich, Germany.
Häberle B; Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, D‑80337 Munich, Germany.
Von Schweinitz D; Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, D‑80337 Munich, Germany.
Kappler R; Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, D‑80337 Munich, Germany.
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Źródło :
International journal of oncology [Int J Oncol] 2019 May; Vol. 54 (5), pp. 1853-1863. Date of Electronic Publication: 2019 Mar 05.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Methylation*/drug effects
Azepines/*pharmacology
Hepatoblastoma/*genetics
Liver Neoplasms/*genetics
N-Myc Proto-Oncogene Protein/*genetics
Neoplasm Proteins/*genetics
Pyrimidines/*pharmacology
RNA, Antisense/*genetics
Triazoles/*pharmacology
Adolescent ; Biomarkers, Tumor/genetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Child ; Child, Preschool ; Early Detection of Cancer ; Epigenesis, Genetic/drug effects ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Infant ; Infant, Newborn ; Male ; N-Myc Proto-Oncogene Protein/drug effects ; Up-Regulation/drug effects
Czasopismo naukowe
Tytuł :
Transcriptome profiling of caspase-2 deficient EμMyc and Th-MYCN mouse tumors identifies distinct putative roles for caspase-2 in neuronal differentiation and immune signaling.
Autorzy :
Dorstyn L; Centre for Cancer Biology, University of South Australia and SA Pathology, GPO Box 2471, Adelaide, SA, 5001, Australia. .
Hackett-Jones E; Centre for Cancer Biology, University of South Australia and SA Pathology, GPO Box 2471, Adelaide, SA, 5001, Australia.
Nikolic A; Centre for Cancer Biology, University of South Australia and SA Pathology, GPO Box 2471, Adelaide, SA, 5001, Australia.
Norris MD; Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW, Sydney, NSW, 2052, Australia.
Lim Y; Centre for Cancer Biology, University of South Australia and SA Pathology, GPO Box 2471, Adelaide, SA, 5001, Australia.
Toubia J; Centre for Cancer Biology, University of South Australia and SA Pathology, GPO Box 2471, Adelaide, SA, 5001, Australia.
Haber M; Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW, Sydney, NSW, 2052, Australia.
Kumar S; Centre for Cancer Biology, University of South Australia and SA Pathology, GPO Box 2471, Adelaide, SA, 5001, Australia. .
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Źródło :
Cell death & disease [Cell Death Dis] 2019 Jan 22; Vol. 10 (2), pp. 56. Date of Electronic Publication: 2019 Jan 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Caspase 2/*deficiency
Lymphoma/*genetics
N-Myc Proto-Oncogene Protein/*genetics
Neuroblastoma/*genetics
Animals ; B-Lymphocytes/metabolism ; B-Lymphocytes/pathology ; Caspase 2/genetics ; Caspase 2/immunology ; Caspase 2/metabolism ; Cell Differentiation/physiology ; Disease Models, Animal ; Gene Expression Profiling ; Lymphoma/immunology ; Lymphoma/metabolism ; Lymphoma/pathology ; Mice ; N-Myc Proto-Oncogene Protein/immunology ; N-Myc Proto-Oncogene Protein/metabolism ; Neuroblastoma/immunology ; Neuroblastoma/metabolism ; Neuroblastoma/pathology ; Neurons/metabolism ; Neurons/pathology ; Signal Transduction/immunology ; Survival Analysis ; Thoracic Neoplasms/genetics ; Thoracic Neoplasms/immunology ; Thoracic Neoplasms/metabolism ; Thoracic Neoplasms/pathology ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism
Czasopismo naukowe

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