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Tytuł:
N-Acetylcysteine Suppresses Microglial Inflammation and Induces Mortality Dose-Dependently via Tumor Necrosis Factor-α Signaling.
Autorzy:
Sakai M; Department of Psychiatric Nursing, Graduate School of Medicine, Tohoku University, Sendai 980-8575, Japan.
Yu Z; Department of Psychiatry, Graduate School of Medicine, Tohoku University, Sendai 980-8575, Japan.
Taniguchi M; Division of Pharmacology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Picotin R; Medical Faculty, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.
Oyama N; Department of Psychiatric Nursing, Graduate School of Medicine, Tohoku University, Sendai 980-8575, Japan.
Stellwagen D; Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Center, Montreal, QC H3G 1A4, Canada.
Ono C; Department of Psychiatry, Graduate School of Medicine, Tohoku University, Sendai 980-8575, Japan.
Kikuchi Y; Department of Psychiatry, Graduate School of Medicine, Tohoku University, Sendai 980-8575, Japan.
Matsui K; Super-network Brain Physiology, Graduate School of Life Sciences, Tohoku University, Sendai 980-8577, Japan.
Nakanishi M; Department of Psychiatric Nursing, Graduate School of Medicine, Tohoku University, Sendai 980-8575, Japan.
Yoshii H; Department of Psychiatric Nursing, Graduate School of Medicine, Tohoku University, Sendai 980-8575, Japan.
Furuyashiki T; Division of Pharmacology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Abe T; Department of Biomedical Engineering Regenerative and Biomedical Engineering Medical Science, Graduate School of Biomedical Engineering, Tohoku University, Sendai 980-8575, Japan.
Tomita H; Department of Psychiatry, Graduate School of Medicine, Tohoku University, Sendai 980-8575, Japan.; Department of Disaster Psychiatry, International Research Institute for Disaster Science, Tohoku University, Sendai 980-8573, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Feb 14; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 14.
Typ publikacji:
Journal Article
MeSH Terms:
Acetylcysteine*/pharmacology
Inflammation*/metabolism
Inflammation*/pathology
Microglia*/drug effects
Microglia*/metabolism
Microglia*/pathology
Tumor Necrosis Factor-alpha*/metabolism
Animals ; Humans ; Mice ; Lipopolysaccharides/pharmacology ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Novel Benzoxazoles Containing 4-Amino-Butanamide Moiety Inhibited LPS-Induced Inflammation by Modulating IL-6 or IL-1β mRNA Expression.
Autorzy:
Yoo J; Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul 03760, Korea.
Park J; Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul 03760, Korea.; Fluorescence Core Imaging Center, Department of Life Science, Ewha Womans University, Seoul 03760, Korea.
Kim D; Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul 03760, Korea.
Huh Y; Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul 03760, Korea.
Park Choo HY; Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul 03760, Korea.
Woo HA; Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul 03760, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 May 10; Vol. 23 (10). Date of Electronic Publication: 2022 May 10.
Typ publikacji:
Journal Article
MeSH Terms:
Benzoxazoles*/pharmacology
Inflammation*/drug therapy
Inflammation*/genetics
Inflammation*/metabolism
Interleukin-6*/genetics
Interleukin-6*/metabolism
RNA, Messenger*/biosynthesis
RNA, Messenger*/genetics
RNA, Messenger*/metabolism
Tumor Necrosis Factor-alpha*/genetics
Tumor Necrosis Factor-alpha*/metabolism
Cytokines/genetics ; Cytokines/metabolism ; Humans ; Lipopolysaccharides/administration & dosage
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Central role for neurally dysregulated IL-17A in dynamic networks of systemic and local inflammation in combat casualties.
Autorzy:
Zamora R; Department of Surgery, University of Pittsburgh, W944 Starzl Biomedical Sciences Tower, 200 Lothrop St., Pittsburgh, PA, 15213, USA.; Center for Inflammation and Regeneration Modeling, McGowan Institute for Regenerative Medicine, Pittsburgh, PA, 15219, USA.; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Forsberg JA; Department of Surgery, Uniformed Services University of Health Sciences and Walter Reed National Military Medical Center, Bethesda, MD, 20814, USA.
Shah AM; Department of Surgery, University of Pittsburgh, W944 Starzl Biomedical Sciences Tower, 200 Lothrop St., Pittsburgh, PA, 15213, USA.
Unselt D; Department of Surgery, Uniformed Services University of Health Sciences and Walter Reed National Military Medical Center, Bethesda, MD, 20814, USA.; Surgical Critical Care Initiative (SC2i), Uniformed Services University of Health Sciences, Bethesda, MD, 20814, USA.; The Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, 20817, USA.
Grey S; Department of Surgery, Uniformed Services University of Health Sciences and Walter Reed National Military Medical Center, Bethesda, MD, 20814, USA.; Surgical Critical Care Initiative (SC2i), Uniformed Services University of Health Sciences, Bethesda, MD, 20814, USA.; The Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, 20817, USA.
Lisboa FA; Department of Surgery, Uniformed Services University of Health Sciences and Walter Reed National Military Medical Center, Bethesda, MD, 20814, USA.; Surgical Critical Care Initiative (SC2i), Uniformed Services University of Health Sciences, Bethesda, MD, 20814, USA.; The Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, 20817, USA.
Billiar TR; Department of Surgery, University of Pittsburgh, W944 Starzl Biomedical Sciences Tower, 200 Lothrop St., Pittsburgh, PA, 15213, USA.; Center for Inflammation and Regeneration Modeling, McGowan Institute for Regenerative Medicine, Pittsburgh, PA, 15219, USA.; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Schobel SA; Department of Surgery, Uniformed Services University of Health Sciences and Walter Reed National Military Medical Center, Bethesda, MD, 20814, USA.; Surgical Critical Care Initiative (SC2i), Uniformed Services University of Health Sciences, Bethesda, MD, 20814, USA.; The Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, 20817, USA.
Potter BK; Department of Surgery, Uniformed Services University of Health Sciences and Walter Reed National Military Medical Center, Bethesda, MD, 20814, USA.; Surgical Critical Care Initiative (SC2i), Uniformed Services University of Health Sciences, Bethesda, MD, 20814, USA.
Elster EA; Department of Surgery, Uniformed Services University of Health Sciences and Walter Reed National Military Medical Center, Bethesda, MD, 20814, USA.; Surgical Critical Care Initiative (SC2i), Uniformed Services University of Health Sciences, Bethesda, MD, 20814, USA.
Vodovotz Y; Department of Surgery, University of Pittsburgh, W944 Starzl Biomedical Sciences Tower, 200 Lothrop St., Pittsburgh, PA, 15213, USA. .; Center for Inflammation and Regeneration Modeling, McGowan Institute for Regenerative Medicine, Pittsburgh, PA, 15219, USA. .; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, 15213, USA. .
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Źródło:
Scientific reports [Sci Rep] 2023 Apr 24; Vol. 13 (1), pp. 6618. Date of Electronic Publication: 2023 Apr 24.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Interleukin-17*/pharmacology
Inflammation*
Humans ; Tumor Necrosis Factor-alpha/pharmacology ; Interferon-gamma/pharmacology ; Biomarkers ; Th17 Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Chlamydia trachomatis antigen induces TLR4-TAB1-mediated inflammation, but not cell death, in maternal decidua cells.
Autorzy:
Ortiz B; School of Medicine, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Driscoll A; School of Medicine, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Menon R; Division of Basic Science and Translational Research, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Taylor BD; Division of Basic Science and Translational Research, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Richardson LS; Division of Basic Science and Translational Research, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
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Źródło:
American journal of reproductive immunology (New York, N.Y. : 1989) [Am J Reprod Immunol] 2023 Mar; Vol. 89 (3), pp. e13664. Date of Electronic Publication: 2022 Dec 19.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Chlamydia trachomatis*/physiology
Inflammation*/metabolism
Toll-Like Receptor 4*/metabolism
Female ; Humans ; Pregnancy ; Adaptor Proteins, Signal Transducing/metabolism ; Cytokines/metabolism ; Decidua/metabolism ; Interleukin-6/metabolism ; Necrosis/metabolism ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
7,8-Dihydroxyflavone Attenuates Inflammatory Response and Insulin Resistance Induced by the Paracrine Interaction between Adipocytes and Macrophages.
Autorzy:
Shin YE; Department of Food Science & Nutrition, The Catholic University of Korea, Bucheon 14662, Republic of Korea.
Choi JW; Department of Biotechnology, Graduate School, The Catholic University of Korea, Bucheon 14662, Republic of Korea.
Park YI; Department of Biotechnology, Graduate School, The Catholic University of Korea, Bucheon 14662, Republic of Korea.
Kim HK; Department of Food Science & Nutrition, The Catholic University of Korea, Bucheon 14662, Republic of Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Feb 09; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 09.
Typ publikacji:
Journal Article
MeSH Terms:
Adipocytes*/metabolism
Inflammation*/metabolism
Insulin Resistance*
Macrophages*/metabolism
Flavones*/metabolism
Flavones*/pharmacology
Animals ; Mice ; 3T3-L1 Cells ; Coculture Techniques ; Insulin/metabolism ; Obesity/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Paracrine Communication
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Teriflunomide shifts the astrocytic bioenergetic profile from oxidative metabolism to glycolysis and attenuates TNFα-induced inflammatory responses.
Autorzy:
Kabiraj P; Department of Neurology, Mayo Clinic, Rochester, MN, 55905, USA.; Translational Neuroimmunology Lab, Mayo Clinic, Guggenheim 1542C, 200 First Street SW, Rochester, MN, 55905, USA.
Grund EM; Translational Neuroimmunology Lab, Mayo Clinic, Guggenheim 1542C, 200 First Street SW, Rochester, MN, 55905, USA.; Mayo Graduate School Neuroscience PhD Program and Medical Scientist Training Program, Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN, 55905, USA.
Clarkson BDS; Department of Neurology, Mayo Clinic, Rochester, MN, 55905, USA.; Translational Neuroimmunology Lab, Mayo Clinic, Guggenheim 1542C, 200 First Street SW, Rochester, MN, 55905, USA.; Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, 55905, USA.
Johnson RK; Department of Neurology, Mayo Clinic, Rochester, MN, 55905, USA.; Translational Neuroimmunology Lab, Mayo Clinic, Guggenheim 1542C, 200 First Street SW, Rochester, MN, 55905, USA.
LaFrance-Corey RG; Department of Neurology, Mayo Clinic, Rochester, MN, 55905, USA.; Translational Neuroimmunology Lab, Mayo Clinic, Guggenheim 1542C, 200 First Street SW, Rochester, MN, 55905, USA.
Lucchinetti CF; Department of Neurology, Mayo Clinic, Rochester, MN, 55905, USA.; Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, 55905, USA.
Howe CL; Department of Neurology, Mayo Clinic, Rochester, MN, 55905, USA. .; Translational Neuroimmunology Lab, Mayo Clinic, Guggenheim 1542C, 200 First Street SW, Rochester, MN, 55905, USA. .; Division of Experimental Neurology, Mayo Clinic, Rochester, MN, 55905, USA. .; Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, 55905, USA. .
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Źródło:
Scientific reports [Sci Rep] 2022 Feb 23; Vol. 12 (1), pp. 3049. Date of Electronic Publication: 2022 Feb 23.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Astrocytes/*metabolism
Crotonates/*pharmacology
Hydroxybutyrates/*pharmacology
Inflammation/*metabolism
Nitriles/*pharmacology
Toluidines/*pharmacology
Tumor Necrosis Factor-alpha/*pharmacology
Adenosine Triphosphate/metabolism ; Animals ; Animals, Newborn ; Astrocytes/cytology ; Astrocytes/drug effects ; Cells, Cultured ; Chemokines/metabolism ; Energy Metabolism/drug effects ; Glycolysis/drug effects ; Lipocalin-2/metabolism ; Mice, Inbred C57BL ; Mitochondria/drug effects ; Oxidation-Reduction/drug effects ; Oxidative Phosphorylation/drug effects ; Tumor Necrosis Factor-alpha/metabolism ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
TNF-α antagonism rescues the effect of ageing on stroke: Perspectives for targeting inflamm-ageing.
Autorzy:
Liberale L; Center for Molecular Cardiology, University of Zürich, Schlieren, Switzerland.; Department of Internal Medicine, First Clinic of Internal Medicine, University of Genoa, Genoa, Italy.
Bonetti NR; Center for Molecular Cardiology, University of Zürich, Schlieren, Switzerland.; Department of Internal Medicine, Cantonal Hospital of Baden, Baden, Switzerland.
Puspitasari YM; Center for Molecular Cardiology, University of Zürich, Schlieren, Switzerland.
Vukolic A; Center for Molecular Cardiology, University of Zürich, Schlieren, Switzerland.
Akhmedov A; Center for Molecular Cardiology, University of Zürich, Schlieren, Switzerland.
Diaz-Cañestro C; Center for Molecular Cardiology, University of Zürich, Schlieren, Switzerland.
Keller S; Center for Molecular Cardiology, University of Zürich, Schlieren, Switzerland.
Montecucco F; Department of Internal Medicine, First Clinic of Internal Medicine, University of Genoa, Genoa, Italy.; IRCCS Ospedale Policlinico San Martino Genoa - Italian Cardiovascular Network, Genoa, Italy.
Merlini M; Blood & Brain @ Caen-Normandie Institute, GIP Cyceron, Caen, France.
Semerano A; Department of Neurology, San Raffaele Scientific Institute, Milano, Italy.
Giacalone G; Department of Neurology, San Raffaele Scientific Institute, Milano, Italy.
Bacigaluppi M; Department of Neurology, San Raffaele Scientific Institute, Milano, Italy.
Sessa M; Department of Neurology, Papa Giovanni XXIII Hospital, Bergamo, Italy.
Ruschitzka F; Department of Cardiology, University Heart Center, University Hospital Zurich, Zurich, Switzerland.
Lüscher TF; Center for Molecular Cardiology, University of Zürich, Schlieren, Switzerland.; Royal Brompton and Harefield Hospitals and Imperial College, London, UK.
Libby P; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Beer JH; Center for Molecular Cardiology, University of Zürich, Schlieren, Switzerland.; Department of Internal Medicine, Cantonal Hospital of Baden, Baden, Switzerland.
Camici GG; Center for Molecular Cardiology, University of Zürich, Schlieren, Switzerland.; Department of Cardiology, University Heart Center, University Hospital Zurich, Zurich, Switzerland.; Department of Research and Education, University Hospital Zurich, Zurich, Switzerland.
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Źródło:
European journal of clinical investigation [Eur J Clin Invest] 2021 Nov; Vol. 51 (11), pp. e13600. Date of Electronic Publication: 2021 Jun 02.
Typ publikacji:
Journal Article
MeSH Terms:
Adalimumab/*pharmacology
Aging/*drug effects
Infarction, Middle Cerebral Artery/*metabolism
Inflammation/*metabolism
Tumor Necrosis Factor Inhibitors/*pharmacology
Tumor Necrosis Factor-alpha/*drug effects
Aged ; Aged, 80 and over ; Aging/metabolism ; Animals ; Blood-Brain Barrier/metabolism ; Cadherins/metabolism ; Female ; Humans ; Interleukin-1beta/metabolism ; Ischemic Stroke/metabolism ; Male ; Mice ; Middle Aged ; Recovery of Function ; Reperfusion Injury/metabolism ; Tight Junction Proteins/metabolism ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Inflammation and necrosis syndrome is associated with alterations in blood and metabolism in pigs.
Autorzy:
Loewenstein F; Department of Veterinary Clinical Sciences, Clinic for Swine, Justus-Liebig-University, Frankfurter Strasse 112, 35392, Giessen, Germany.; LSZ Boxberg, Seehöfer Str. 50, 97944, Boxberg, Germany.
Becker S; Department of Veterinary Clinical Sciences, Clinic for Swine, Justus-Liebig-University, Frankfurter Strasse 112, 35392, Giessen, Germany.
Kuehling J; Department of Veterinary Clinical Sciences, Clinic for Swine, Justus-Liebig-University, Frankfurter Strasse 112, 35392, Giessen, Germany.
Schrade H; LSZ Boxberg, Seehöfer Str. 50, 97944, Boxberg, Germany.
Lechner M; UEG Hohenlohe, Am Wasen 20, 91567, Herrieden, Germany.
Ringseis R; Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig University Giessen, Heinrich-Buff-Ring 26-32, 35392, Giessen, Germany.
Eder K; Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig University Giessen, Heinrich-Buff-Ring 26-32, 35392, Giessen, Germany.
Moritz A; Department of Veterinary Clinical Sciences, Clinic for Small Animals, Justus-Liebig-University, Frankfurter Strasse, 35392, Giessen, Germany.
Reiner G; Department of Veterinary Clinical Sciences, Clinic for Swine, Justus-Liebig-University, Frankfurter Strasse 112, 35392, Giessen, Germany. .
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Źródło:
BMC veterinary research [BMC Vet Res] 2022 Jan 19; Vol. 18 (1), pp. 50. Date of Electronic Publication: 2022 Jan 19.
Typ publikacji:
Journal Article
MeSH Terms:
Inflammation*/veterinary
Necrosis*/veterinary
Swine Diseases*/blood
Swine Diseases*/metabolism
Acute-Phase Proteins ; Animals ; Swine
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Effects of tumor necrosis factor-α inhibition on kidney fibrosis and inflammation in a mouse model of aristolochic acid nephropathy.
Autorzy:
Taguchi S; Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan.
Azushima K; Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan. .
Yamaji T; Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan.; Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore, Singapore.
Urate S; Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan.
Suzuki T; Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan.
Abe E; Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan.
Tanaka S; Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan.
Tsukamoto S; Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan.
Kamimura D; Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan.
Kinguchi S; Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan.
Yamashita A; Department of Investigative Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Wakui H; Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan. .
Tamura K; Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan.
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Źródło:
Scientific reports [Sci Rep] 2021 Dec 08; Vol. 11 (1), pp. 23587. Date of Electronic Publication: 2021 Dec 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Aristolochic Acids/*pharmacology
Fibrosis/*metabolism
Inflammation/*metabolism
Kidney/*metabolism
Renal Insufficiency, Chronic/*chemically induced
Renal Insufficiency, Chronic/*metabolism
Tumor Necrosis Factor-alpha/*antagonists & inhibitors
Albuminuria/drug therapy ; Albuminuria/metabolism ; Animals ; Collagen/metabolism ; Disease Models, Animal ; Etanercept/pharmacology ; Fibrosis/drug therapy ; Inflammation/drug therapy ; Interleukin-1beta/metabolism ; Interleukin-6/metabolism ; Kidney/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; RNA, Messenger/metabolism ; Renal Insufficiency, Chronic/drug therapy ; Tumor Necrosis Factor-alpha/metabolism ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Ataxin-10 Inhibits TNF- α -Induced Endothelial Inflammation via Suppressing Interferon Regulatory Factor-1.
Autorzy:
Li Y; Department of Anesthesiology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Zhang Q; The National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, China.
Li N; School of Future Technology, Nanchang University, Nanchang, China.
Ding L; The National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, China.
Yi J; Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Xiao Y; First School of Clinical Medicine, Nanchang University, Nanchang, China.
Chen S; Department of Anesthesiology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Huang X; The National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, China.
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Źródło:
Mediators of inflammation [Mediators Inflamm] 2021 Nov 23; Vol. 2021, pp. 7042148. Date of Electronic Publication: 2021 Nov 23 (Print Publication: 2021).
Typ publikacji:
Journal Article
MeSH Terms:
Ataxin-10/*physiology
Endothelial Cells/*drug effects
Inflammation/*prevention & control
Interferon Regulatory Factor-1/*antagonists & inhibitors
Tumor Necrosis Factor-alpha/*pharmacology
Atherosclerosis/etiology ; Cells, Cultured ; Endothelial Cells/physiology ; Human Umbilical Vein Endothelial Cells ; Humans ; Monocytes/physiology ; NF-kappa B/physiology ; Tumor Necrosis Factor-alpha/antagonists & inhibitors ; Vascular Cell Adhesion Molecule-1/analysis ; Vascular Cell Adhesion Molecule-1/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Desulfovibrio fairfieldensis -Derived Outer Membrane Vesicles Damage Epithelial Barrier and Induce Inflammation and Pyroptosis in Macrophages.
Autorzy:
Nie Y; School of Life Sciences and Health Engineering, Jiangnan University, Wuxi 214122, China.
Xie XQ; School of Life Sciences and Health Engineering, Jiangnan University, Wuxi 214122, China.
Zhou L; The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China.
Guan Q; National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi 214122, China.; Jiangsu Engineering Research Center for Bioactive Products Processing Technology, Jiangnan University, Wuxi 214122, China.
Ren Y; Department of Gastroenterology, Affiliated Hospital of Jiangnan University, Wuxi 214122, China.
Mao Y; Department of Oncology, Affiliated Hospital of Jiangnan University, Wuxi214122, China.
Shi JS; School of Life Sciences and Health Engineering, Jiangnan University, Wuxi 214122, China.
Xu ZH; The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China.; National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi 214122, China.; Jiangsu Engineering Research Center for Bioactive Products Processing Technology, Jiangnan University, Wuxi 214122, China.
Geng Y; School of Life Sciences and Health Engineering, Jiangnan University, Wuxi 214122, China.
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Źródło:
Cells [Cells] 2022 Dec 25; Vol. 12 (1). Date of Electronic Publication: 2022 Dec 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Pyroptosis*
Inflammation*/metabolism
Humans ; Caco-2 Cells ; Tumor Necrosis Factor-alpha/metabolism ; Macrophages/metabolism
SCR Organism:
Desulfovibrio fairfieldensis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Effects of exercise on inflammatory factors and IGF system in breast cancer survivors: a meta-analysis.
Autorzy:
Zhou Y; College of Physical Education, Shandong Normal University, Jinan, 250014, China.
Jia N; College of Physical Education, Shandong Normal University, Jinan, 250014, China.
Ding M; College of Physical Education, Shandong Normal University, Jinan, 250014, China.
Yuan K; Department of General Surgery, The First Affiliated Hospital of Shandong First Medical University, Jinan, 262799, Shandong, China. .
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Źródło:
BMC women's health [BMC Womens Health] 2022 Dec 08; Vol. 22 (1), pp. 507. Date of Electronic Publication: 2022 Dec 08.
Typ publikacji:
Systematic Review; Meta-Analysis; Journal Article
MeSH Terms:
Cancer Survivors*
Exercise*
Breast Neoplasms*/metabolism
Inflammation*
Humans ; Insulin-Like Growth Factor I ; Interleukin-10 ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Female
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Randomized, double-blinded, controlled clinical trial of the effect of captopril, telmisartan and their combination on systemic inflammation of patients on hemodialysis.
Autorzy:
Ordaz-Medina SM; Unidad de Investigación Médica en Enfermedades Renales, Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Belisario Domínguez No. 1000, Col. Independencia, CP 44320, Guadalajara, Jalisco, Mexico.
Cueto-Manzano AM; Unidad de Investigación Médica en Enfermedades Renales, Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Belisario Domínguez No. 1000, Col. Independencia, CP 44320, Guadalajara, Jalisco, Mexico. a_cueto_.
González-Plascencia J; Departamento de Nefrología, Hospital General Regional No. 110, IMSS, Guadalajara, Jalisco, Mexico.
Montañez-Fernández JL; Departamento de Nefrología, Hospital General Regional No. 110, IMSS, Guadalajara, Jalisco, Mexico.
Ordaz-Medina EJ; Unidad de Investigación Médica en Enfermedades Renales, Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Belisario Domínguez No. 1000, Col. Independencia, CP 44320, Guadalajara, Jalisco, Mexico.
Martín-Del-Campo F; Unidad de Investigación Médica en Enfermedades Renales, Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Belisario Domínguez No. 1000, Col. Independencia, CP 44320, Guadalajara, Jalisco, Mexico.
Cueto-Ramírez AM; Unidad de Investigación Médica en Enfermedades Renales, Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Belisario Domínguez No. 1000, Col. Independencia, CP 44320, Guadalajara, Jalisco, Mexico.
Martínez-Martínez P; Unidad de Investigación Médica en Enfermedades Renales, Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Belisario Domínguez No. 1000, Col. Independencia, CP 44320, Guadalajara, Jalisco, Mexico.
Cortés-Sanabria L; Unidad de Investigación Médica en Enfermedades Renales, Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Belisario Domínguez No. 1000, Col. Independencia, CP 44320, Guadalajara, Jalisco, Mexico.
Rojas-Campos E; Unidad de Investigación Médica en Enfermedades Renales, Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Belisario Domínguez No. 1000, Col. Independencia, CP 44320, Guadalajara, Jalisco, Mexico.
Trujillo-Hernández B; Facultad de Medicina, Universidad de Colima, Colima, Colima, Mexico.
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Źródło:
Scientific reports [Sci Rep] 2022 Oct 20; Vol. 12 (1), pp. 17568. Date of Electronic Publication: 2022 Oct 20.
Typ publikacji:
Randomized Controlled Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Captopril*/therapeutic use
Inflammation*/drug therapy
Inflammation*/etiology
Renal Dialysis*/adverse effects
Telmisartan*/therapeutic use
Humans ; Biomarkers ; C-Reactive Protein/metabolism ; Double-Blind Method ; Interleukin-6 ; Tumor Necrosis Factor-alpha
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Having an Old Friend for Dinner: The Interplay between Apoptotic Cells and Efferocytes.
Autorzy:
Lam AL; Department of Microbiology and Immunology and the Center for Human Immunology, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada.
Heit B; Department of Microbiology and Immunology and the Center for Human Immunology, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada.; Robarts Research Institute, London, ON N6A 3K7, Canada.
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Źródło:
Cells [Cells] 2021 May 20; Vol. 10 (5). Date of Electronic Publication: 2021 May 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Apoptosis*
Necrosis*
Phagocytosis*
Inflammation/*immunology
Inflammation/*pathology
Animals ; Humans ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The CD200 Regulates Inflammation in Mice Independently of TNF-α Production.
Autorzy:
Tonecka K; Department of Immunology, Medical University of Warsaw, 02-097 Warsaw, Poland.
Braniewska A; Department of Immunology, Medical University of Warsaw, 02-097 Warsaw, Poland.
Pilch Z; Department of Immunology, Medical University of Warsaw, 02-097 Warsaw, Poland.
Sas Z; Department of Immunology, Medical University of Warsaw, 02-097 Warsaw, Poland.
Skorzynski M; Department of Immunology, Medical University of Warsaw, 02-097 Warsaw, Poland.
Manuali E; Laboratory of Veterinary and Comparative Histopathology, Istituto Zooprofilattico Sperimentale Umbria e Marche 'Togo Rosati', 06126 Perugia, Italy.
Rygiel TP; Department of Immunology, Medical University of Warsaw, 02-097 Warsaw, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 May 19; Vol. 22 (10). Date of Electronic Publication: 2021 May 19.
Typ publikacji:
Journal Article
MeSH Terms:
Antigens, CD/*genetics
Inflammation/*immunology
Tumor Necrosis Factor-alpha/*metabolism
Animals ; Antigens, CD/metabolism ; Colitis/pathology ; Colon/pathology ; Cytokines/metabolism ; Endothelial Cells/metabolism ; Female ; Gene Expression/genetics ; Gene Expression Regulation/genetics ; Inflammation/genetics ; Inflammatory Bowel Diseases/metabolism ; Inflammatory Bowel Diseases/physiopathology ; Macrophages/metabolism ; Male ; Membrane Glycoproteins/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, Immunologic/metabolism ; Tumor Necrosis Factor-alpha/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
MicroRNA23a Overexpression in Crohn's Disease Targets Tumour Necrosis Factor Alpha Inhibitor Protein 3, Increasing Sensitivity to TNF and Modifying the Epithelial Barrier.
Autorzy:
Felwick RK; Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton School of Medicine, Southampton, UK.; Gastroenterology, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Dingley GJR; Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton School of Medicine, Southampton, UK.; Wessex Renal and Transplant Unit, Queen Alexandra Hospital, Cosham, Portsmouth, UK.
Martinez-Nunez R; Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton School of Medicine, Southampton, UK.; MRC-Asthma UK Centre, King's College London, London, UK.
Sanchez-Elsner T; Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton School of Medicine, Southampton, UK.
Cummings JRF; Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton School of Medicine, Southampton, UK.; Gastroenterology, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Collins JE; Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton School of Medicine, Southampton, UK.
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Źródło:
Journal of Crohn's & colitis [J Crohns Colitis] 2020 Mar 13; Vol. 14 (3), pp. 381-392.
Typ publikacji:
Journal Article
MeSH Terms:
Crohn Disease*/genetics
Crohn Disease*/immunology
Inflammation/*metabolism
Intestinal Mucosa/*metabolism
MicroRNAs/*genetics
Tumor Necrosis Factor alpha-Induced Protein 3/*metabolism
Biopsy/methods ; Gene Expression Regulation/immunology ; Humans ; Immunohistochemistry ; Laser Capture Microdissection/methods ; NF-kappa B/metabolism ; Permeability ; Signal Transduction ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Non-granulomatous inflammatory lesions of CNS: Approach to diagnosis.
Autorzy:
Nandeesh BN; Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Rao S; Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Mahadevan A; Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
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Źródło:
Indian journal of pathology & microbiology [Indian J Pathol Microbiol] 2022 May; Vol. 65 (Supplement), pp. S135-S145.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Fungi*
Inflammation*
Humans ; Necrosis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
In Silico Characterization of Growth Differentiation Factors as Inhibitors of TNF-Alpha and IL-6 in Immune-Mediated Inflammatory Disease Rheumatoid Arthritis.
Autorzy:
Mustafa G; Department of Biochemistry, Government College University, Faisalabad 38000, Pakistan.
Mahrosh HS; Department of Biochemistry, Government College University, Faisalabad 38000, Pakistan.
Arif R; Department of Biochemistry, Government College University, Faisalabad 38000, Pakistan.
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Źródło:
BioMed research international [Biomed Res Int] 2021 Mar 26; Vol. 2021, pp. 5538535. Date of Electronic Publication: 2021 Mar 26 (Print Publication: 2021).
Typ publikacji:
Journal Article; Retracted Publication
MeSH Terms:
Computer Simulation*
Arthritis, Rheumatoid/*immunology
Arthritis, Rheumatoid/*metabolism
Bone Morphogenetic Proteins/*metabolism
Growth Differentiation Factors/*metabolism
Inflammation/*pathology
Interleukin-6/*antagonists & inhibitors
Tumor Necrosis Factor-alpha/*antagonists & inhibitors
Amino Acid Sequence ; Biological Availability ; Bone Morphogenetic Proteins/genetics ; Growth Differentiation Factors/genetics ; Humans ; Interleukin-6/metabolism ; Ligands ; Molecular Docking Simulation ; Peptides/chemistry ; Peptides/metabolism ; Peptides/pharmacokinetics ; Phylogeny ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
High Inflammatory Factor Levels Increase Cardiovascular Complications in Diabetic Patients Undergoing Coronary Artery Bypass Grafting.
Autorzy:
Chen J; Department of Radiology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou 213164, China.
Wu Q; Department of Thoracic and Cardiac Surgery, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou 213164, China.
Shi H; Department of Radiology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou 213164, China.
Zhang Y; Department of Radiology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou 213164, China.
Wang T; Department of Radiology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou 213164, China.
Yin R; Department of Radiology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou 213164, China.
Pan C; Department of Radiology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou 213164, China.
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Źródło:
BioMed research international [Biomed Res Int] 2022 May 21; Vol. 2022, pp. 7151414. Date of Electronic Publication: 2022 May 21 (Print Publication: 2022).
Typ publikacji:
Journal Article; Retracted Publication
MeSH Terms:
Coronary Artery Disease*/complications
Coronary Artery Disease*/surgery
Diabetes Mellitus*
Inflammation*/complications
Coronary Artery Bypass ; Humans ; Interleukin-18 ; Interleukin-6 ; Tumor Necrosis Factor-alpha
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Characterization of a Cutibacterium acnes Camp Factor 1-Related Peptide as a New TLR-2 Modulator in In Vitro and Ex Vivo Models of Inflammation.
Autorzy:
Mayslich C; Département DRC, Développement, Reproduction et Cancer, Institut Cochin, INSERM U1016-CNRS UMR8104, Université Paris Cité, 75014 Paris, France.
Grange PA; Département DRC, Développement, Reproduction et Cancer, Institut Cochin, INSERM U1016-CNRS UMR8104, Université Paris Cité, 75014 Paris, France.; Service de Dermatologie-Vénéréologie et CeGIDD, Groupe Hospitalier APHP.centre, CNR IST Bactériennes-Laboratoire Associé Syphilis, 75014 Paris, France.; Hôpital Cochin, U1016, Equipe Biologie Cutanée-CNR IST bactériennes-Syphilis 24, rue du faubourg Saint-Jacques, 75014 Paris, France.
Castela M; Département DRC, Développement, Reproduction et Cancer, Institut Cochin, INSERM U1016-CNRS UMR8104, Université Paris Cité, 75014 Paris, France.
Marcelin AG; National Reference Centre for Herpesviruses, Virology Department, Team 3 THERAVIR, and AP-HP, Pitié-Salpêtrière-Charles Foix University Hospital, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), INSERM, Sorbonne Université, 75013 Paris, France.
Calvez V; National Reference Centre for Herpesviruses, Virology Department, Team 3 THERAVIR, and AP-HP, Pitié-Salpêtrière-Charles Foix University Hospital, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), INSERM, Sorbonne Université, 75013 Paris, France.
Dupin N; Département DRC, Développement, Reproduction et Cancer, Institut Cochin, INSERM U1016-CNRS UMR8104, Université Paris Cité, 75014 Paris, France.; Service de Dermatologie-Vénéréologie et CeGIDD, Groupe Hospitalier APHP.centre, CNR IST Bactériennes-Laboratoire Associé Syphilis, 75014 Paris, France.; Hôpital Cochin, U1016, Equipe Biologie Cutanée-CNR IST bactériennes-Syphilis 24, rue du faubourg Saint-Jacques, 75014 Paris, France.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 May 03; Vol. 23 (9). Date of Electronic Publication: 2022 May 03.
Typ publikacji:
Journal Article
MeSH Terms:
Bacterial Proteins*/pharmacology
Bacterial Proteins*/therapeutic use
Inflammation*/drug therapy
Inflammation*/metabolism
Propionibacteriaceae*/chemistry
Toll-Like Receptor 2*/genetics
Toll-Like Receptor 2*/metabolism
Chemokines/metabolism ; Granulocyte-Macrophage Colony-Stimulating Factor/metabolism ; Humans ; Interleukin-10/metabolism ; Ligands ; Peptides/pharmacology ; Peptides/therapeutic use ; Tumor Necrosis Factor-alpha/metabolism
SCR Organism:
Cutibacterium acnes subsp. acnes
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 33087

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