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Wyszukujesz frazę ""NERVE growth factor"" wg kryterium: Temat


Tytuł :
Nerve Growth Factor: The First Molecule of the Neurotrophin Family.
Autorzy :
Lorenzini L; Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy.; Health Science and Technologies Interdepartmental Center for Industrial Research (HST-ICIR), University of Bologna, Bologna, Italy.
Baldassarro VA; Health Science and Technologies Interdepartmental Center for Industrial Research (HST-ICIR), University of Bologna, Bologna, Italy.
Stanzani A; Health Science and Technologies Interdepartmental Center for Industrial Research (HST-ICIR), University of Bologna, Bologna, Italy.
Giardino L; Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy. .; Health Science and Technologies Interdepartmental Center for Industrial Research (HST-ICIR), University of Bologna, Bologna, Italy. .; IRET Foundation, Bologna, Italy. .
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Źródło :
Advances in experimental medicine and biology [Adv Exp Med Biol] 2021; Vol. 1331, pp. 3-10.
Typ publikacji :
Journal Article
MeSH Terms :
Receptors, Nerve Growth Factor*/genetics
Signal Transduction*
Cell Differentiation ; Nerve Growth Factor/genetics ; Neurogenesis ; Protein Binding
Czasopismo naukowe
Tytuł :
c-Jun N-terminal Kinase Mediates Ligand-independent p75 Signaling in Mesencephalic Cells Subjected to Oxidative Stress.
Autorzy :
Kraemer BR; From the Department of Biological Sciences, Eastern Kentucky University, Richmond, KY 40475, United States. Electronic address: .
Clements RT; From the Department of Biological Sciences, Eastern Kentucky University, Richmond, KY 40475, United States.
Escobedo CM; From the Department of Biological Sciences, Eastern Kentucky University, Richmond, KY 40475, United States.
Nelson KS; From the Department of Biological Sciences, Eastern Kentucky University, Richmond, KY 40475, United States.
Waugh CD; From the Department of Biological Sciences, Eastern Kentucky University, Richmond, KY 40475, United States.
Elliott AS; From the Department of Biological Sciences, Eastern Kentucky University, Richmond, KY 40475, United States.
Hall WC; From the Department of Biological Sciences, Eastern Kentucky University, Richmond, KY 40475, United States.
Schemanski MT; From the Department of Biological Sciences, Eastern Kentucky University, Richmond, KY 40475, United States.
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Źródło :
Neuroscience [Neuroscience] 2021 Jan 15; Vol. 453, pp. 222-236. Date of Electronic Publication: 2020 Nov 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
JNK Mitogen-Activated Protein Kinases*/metabolism
Receptors, Nerve Growth Factor*/metabolism
Humans ; Ligands ; Mesencephalon/metabolism ; Oxidative Stress ; Receptor, Nerve Growth Factor/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
The Effects of P75NTR on Learning Memory Mediated by Hippocampal Apoptosis and Synaptic Plasticity.
Autorzy :
Tang JJ; College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China.
Feng S; College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China.
Chen XD; College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China.
Huang H; College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China.
Mao M; College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China.
Wang HY; State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital, Army Medical University, Chongqing 400042, China.
Li S; State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital, Army Medical University, Chongqing 400042, China.
Lu XM; College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China.
Wang YT; State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital, Army Medical University, Chongqing 400042, China.
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Źródło :
Current pharmaceutical design [Curr Pharm Des] 2021; Vol. 27 (4), pp. 531-539.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hippocampus*/metabolism
Receptors, Nerve Growth Factor*/metabolism
Apoptosis ; Humans ; Nerve Tissue Proteins ; Neuronal Plasticity ; Receptor, Nerve Growth Factor/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Modulation of p75 on Mesenchymal Stem Cells Increases Their Vascular Protection in Retinal Ischemia-Reperfusion Mouse Model.
Autorzy :
Elshaer SL; Augusta Biomedical Research Corporation, Charlie Norwood VA Medical Center, Augusta, GA 30901, USA.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
Park HS; Department of Surgery, University of Illinois at Chicago, Chicago, IL 60612, USA.; Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL 60637, USA.
Pearson L; Augusta Biomedical Research Corporation, Charlie Norwood VA Medical Center, Augusta, GA 30901, USA.
Hill WD; Augusta Biomedical Research Corporation, Charlie Norwood VA Medical Center, Augusta, GA 30901, USA.; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29403, USA.; Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC 29403, USA.
Longo FM; Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, CA 94304, USA.
El-Remessy AB; Augusta Biomedical Research Corporation, Charlie Norwood VA Medical Center, Augusta, GA 30901, USA.; Department of Surgery, University of Illinois at Chicago, Chicago, IL 60612, USA.; Department of the Pharmacy, Doctors Hospital of Augusta, Augusta, GA 30909, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jan 15; Vol. 22 (2). Date of Electronic Publication: 2021 Jan 15.
Typ publikacji :
Journal Article
MeSH Terms :
Mesenchymal Stem Cells/*cytology
Receptors, Nerve Growth Factor/*genetics
Reperfusion Injury/*metabolism
Retinal Vessels/*metabolism
Animals ; Capillaries/metabolism ; Cell Movement ; Cell Proliferation ; Coculture Techniques ; Culture Media, Conditioned/chemistry ; Disease Models, Animal ; Endothelial Cells/metabolism ; Endothelium/metabolism ; Gene Deletion ; Gene Silencing ; Green Fluorescent Proteins/metabolism ; Humans ; Intravitreal Injections ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neovascularization, Pathologic ; Nerve Growth Factor/metabolism ; Nerve Tissue Proteins/genetics ; Receptor, Nerve Growth Factor/metabolism ; Reperfusion Injury/genetics ; Vascular Endothelial Growth Factor A/metabolism
Czasopismo naukowe
Tytuł :
Downregulation of OIP5-AS1 affects proNGF-induced pancreatic cancer metastasis by inhibiting p75NTR levels.
Autorzy :
Li A; Department of Pancreatic Surgery, West China Hospital of Sichuan University, Chengdu 610041, China.
Feng L; Department of Biliary Surgery, West China Hospital of Sichuan University, Chengdu 610041, China.
Niu X; Department of Biliary Surgery, West China Hospital of Sichuan University, Chengdu 610041, China.
Zeng Q; Department of Biliary Surgery, West China Hospital of Sichuan University, Chengdu 610041, China.
Li B; Department of Biliary Surgery, West China Hospital of Sichuan University, Chengdu 610041, China.
You Z; Department of Biliary Surgery, West China Hospital of Sichuan University, Chengdu 610041, China.
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Źródło :
Aging [Aging (Albany NY)] 2021 Apr 03; Vol. 13 (7), pp. 10688-10702. Date of Electronic Publication: 2021 Apr 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Down-Regulation*
Neoplasm Metastasis/*genetics
Nerve Growth Factor/*metabolism
Nerve Tissue Proteins/*metabolism
Pancreatic Neoplasms/*metabolism
Protein Precursors/*metabolism
RNA, Long Noncoding/*metabolism
Receptors, Nerve Growth Factor/*metabolism
Cell Line, Tumor ; Databases, Factual ; Gene Expression Regulation, Neoplastic ; Humans ; Neoplasm Metastasis/pathology ; Nerve Growth Factor/genetics ; Nerve Tissue Proteins/genetics ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/pathology ; Prognosis ; Protein Precursors/genetics ; RNA, Long Noncoding/genetics ; Receptors, Nerve Growth Factor/genetics ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł :
Nerve Growth Factor: A Potential Therapeutic Target for Lung Diseases.
Autorzy :
Liu P; Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China.
Li S; Department of Immunology, School of Basic Medical Sciences, Chengdu Medical College, Chengdu 610500, China.; Non-Coding RNA and Drug Discovery Key Laboratory of Sichuan Province, Chengdu Medical College, Chengdu 610500, China.
Tang L; Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 24; Vol. 22 (17). Date of Electronic Publication: 2021 Aug 24.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Airway Remodeling/*drug effects
Lung/*pathology
Nerve Growth Factor/*antagonists & inhibitors
Signal Transduction/*drug effects
Asthma/drug therapy ; Asthma/pathology ; COVID-19/drug therapy ; COVID-19/pathology ; Humans ; Hypertension, Pulmonary/drug therapy ; Hypertension, Pulmonary/pathology ; Lung/drug effects ; Lung Neoplasms/drug therapy ; Lung Neoplasms/pathology ; Molecular Targeted Therapy/methods ; Nerve Growth Factor/metabolism ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Pulmonary Disease, Chronic Obstructive/pathology ; Pulmonary Fibrosis/drug therapy ; Pulmonary Fibrosis/pathology
Czasopismo naukowe
Tytuł :
NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma.
Autorzy :
Lee S; Department of Pathology, Johns Hopkins University, Baltimore, MD, USA.
Hwang C; Department of Surgery, Center for Organogenesis and Trauma, University of Texas, Southwestern, TX, USA.
Marini S; Department of Epidemiology, University of Florida, Gainesville, FL, USA.
Tower RJ; Department of Orthopaedics, Johns Hopkins University, Baltimore, MD, USA.
Qin Q; Department of Pathology, Johns Hopkins University, Baltimore, MD, USA.
Negri S; Department of Pathology, Johns Hopkins University, Baltimore, MD, USA.; Department of Orthopaedics and Traumatology, University of Verona, Verona, Italy.
Pagani CA; Department of Surgery, Center for Organogenesis and Trauma, University of Texas, Southwestern, TX, USA.
Sun Y; Department of Surgery, Center for Organogenesis and Trauma, University of Texas, Southwestern, TX, USA.
Stepien DM; Department of Surgery, Center for Organogenesis and Trauma, University of Texas, Southwestern, TX, USA.
Sorkin M; Department of Surgery, Center for Organogenesis and Trauma, University of Texas, Southwestern, TX, USA.
Kubiak CA; Department of Surgery, Center for Organogenesis and Trauma, University of Texas, Southwestern, TX, USA.
Visser ND; Department of Surgery, Center for Organogenesis and Trauma, University of Texas, Southwestern, TX, USA.
Meyers CA; Department of Pathology, Johns Hopkins University, Baltimore, MD, USA.
Wang Y; Department of Pathology, Johns Hopkins University, Baltimore, MD, USA.
Rasheed HA; Department of Surgery, Center for Organogenesis and Trauma, University of Texas, Southwestern, TX, USA.
Xu J; Department of Pathology, Johns Hopkins University, Baltimore, MD, USA.
Miller S; Department of Pathology, Johns Hopkins University, Baltimore, MD, USA.
Huber AK; Department of Surgery, Center for Organogenesis and Trauma, University of Texas, Southwestern, TX, USA.
Minichiello L; Department of Pharmacology, Oxford University, Oxford, UK.
Cederna PS; Department of Surgery, Center for Organogenesis and Trauma, University of Texas, Southwestern, TX, USA.
Kemp SWP; Department of Surgery, Center for Organogenesis and Trauma, University of Texas, Southwestern, TX, USA.
Clemens TL; Department of Orthopaedics, Johns Hopkins University, Baltimore, MD, USA.; Baltimore Veterans Administration Medical Center, Baltimore, MD, USA.
James AW; Department of Pathology, Johns Hopkins University, Baltimore, MD, USA. .
Levi B; Department of Surgery, Center for Organogenesis and Trauma, University of Texas, Southwestern, TX, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Aug 16; Vol. 12 (1), pp. 4939. Date of Electronic Publication: 2021 Aug 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Cell Differentiation*
Signal Transduction*
Nerve Growth Factor/*metabolism
Receptor, trkA/*metabolism
Wounds and Injuries/*metabolism
Animals ; Axons/metabolism ; Cartilage/metabolism ; Mice ; Mice, Inbred C57BL ; Nerve Growth Factor/genetics ; Osteogenesis ; Stem Cells/metabolism ; Wounds and Injuries/pathology
Czasopismo naukowe
Tytuł :
Effect of cat seminal plasma and purified llama ovulation-inducing factor (β-NGF) on ovarian function in queens.
Autorzy :
Nuñez Favre R; CONICET, Godoy Cruz 2290, CABA, C1425FQB, Argentina; Instituto de Investigaciones en Reproduccion Animal (INIRA), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Calle 60 y 118, La Plata, B1900AVW, Buenos Aires, Argentina. Electronic address: .
García MF; CONICET, Godoy Cruz 2290, CABA, C1425FQB, Argentina; Instituto de Investigaciones en Reproduccion Animal (INIRA), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Calle 60 y 118, La Plata, B1900AVW, Buenos Aires, Argentina.
Ratto MH; Departamento de Ciencia Animal, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, Valdivia, Los Ríos, Chile.
Rearte R; CONICET, Godoy Cruz 2290, CABA, C1425FQB, Argentina; Cátedra de Epidemiología y Salud Pública, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Calle 60 y 118, La Plata, B1900AVW, Buenos Aires, Argentina.
Stornelli MC; Instituto de Investigaciones en Reproduccion Animal (INIRA), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Calle 60 y 118, La Plata, B1900AVW, Buenos Aires, Argentina.
de la Sota RL; CONICET, Godoy Cruz 2290, CABA, C1425FQB, Argentina; Instituto de Investigaciones en Reproduccion Animal (INIRA), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Calle 60 y 118, La Plata, B1900AVW, Buenos Aires, Argentina.
Stornelli MA; Instituto de Investigaciones en Reproduccion Animal (INIRA), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Calle 60 y 118, La Plata, B1900AVW, Buenos Aires, Argentina.
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Źródło :
Theriogenology [Theriogenology] 2021 Jul 15; Vol. 169, pp. 29-35. Date of Electronic Publication: 2021 Apr 21.
Typ publikacji :
Journal Article
MeSH Terms :
Nerve Growth Factor*
Semen*
Ovary/*physiology
Animals ; Camelids, New World ; Cats ; Female ; Male ; Ovulation ; Progesterone
Czasopismo naukowe
Tytuł :
Acceleration of TAA-Induced Liver Fibrosis by Stress Exposure Is Associated with Upregulation of Nerve Growth Factor and Glycopattern Deviations.
Autorzy :
Atorrasagasti C; Instituto de Investigaciones en Medicina Traslacional, Facultad de Ciencias Biomédicas, CONICET, Universidad Austral, Derqui-Pilar B1629, Argentina.
Piccioni F; Laboratorio de Oncología Molecular y Nuevos Blancos Terapéuticos, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires C1428, Argentina.
Borowski S; Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; Experimental and Clinical Research Center, a Cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association, and the Charité-Universitätsmedizin Berlin, AG GlycoImmunology, 13125 Berlin, Germany.
Tirado-González I; Experimental and Clinical Research Center, a Cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association, and the Charité-Universitätsmedizin Berlin, AG GlycoImmunology, 13125 Berlin, Germany.; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, 60596 Frankfurt, Germany.
Freitag N; Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; Experimental and Clinical Research Center, a Cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association, and the Charité-Universitätsmedizin Berlin, AG GlycoImmunology, 13125 Berlin, Germany.
Cantero MJ; Instituto de Investigaciones en Medicina Traslacional, Facultad de Ciencias Biomédicas, CONICET, Universidad Austral, Derqui-Pilar B1629, Argentina.
Bayo J; Instituto de Investigaciones en Medicina Traslacional, Facultad de Ciencias Biomédicas, CONICET, Universidad Austral, Derqui-Pilar B1629, Argentina.
Mazzolini G; Instituto de Investigaciones en Medicina Traslacional, Facultad de Ciencias Biomédicas, CONICET, Universidad Austral, Derqui-Pilar B1629, Argentina.
Alaniz LD; Laboratorio de Microambiente Tumoral, Centro de Investigaciones Básicas y Aplicadas (CIBA), Centro de Investigaciones y Transferencia del Noroeste de la Pcia. de Bs. As. (CIT NOBA UNNOBA-CONICET), Universidad Nacional del Noroeste de la Pcia. de Bs. As., Junín B6000, Argentina.
Blois SM; Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Garcia MG; Instituto de Investigaciones en Medicina Traslacional, Facultad de Ciencias Biomédicas, CONICET, Universidad Austral, Derqui-Pilar B1629, Argentina.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 11; Vol. 22 (10). Date of Electronic Publication: 2021 May 11.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation*
Stress, Physiological*
Liver Cirrhosis/*pathology
Nerve Growth Factor/*metabolism
Polysaccharides/*metabolism
Receptors, Nerve Growth Factor/*metabolism
Thioacetamide/*toxicity
Animals ; Liver Cirrhosis/chemically induced ; Liver Cirrhosis/genetics ; Liver Cirrhosis/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Nerve Growth Factor/genetics ; Receptors, Nerve Growth Factor/genetics
Czasopismo naukowe
Tytuł :
Valproic acid upregulates the expression of the p75NTR/sortilin receptor complex to induce neuronal apoptosis.
Autorzy :
Dedoni S; Laboratory of Cellular and Molecular Pharmacology, Section of Neurosciences and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, 09042, Monserrato, CA, Italy.
Marras L; Section of Microbiology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Olianas MC; Laboratory of Cellular and Molecular Pharmacology, Section of Neurosciences and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, 09042, Monserrato, CA, Italy.
Ingianni A; Section of Microbiology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Onali P; Laboratory of Cellular and Molecular Pharmacology, Section of Neurosciences and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, 09042, Monserrato, CA, Italy. .
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Źródło :
Apoptosis : an international journal on programmed cell death [Apoptosis] 2020 Oct; Vol. 25 (9-10), pp. 697-714.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Vesicular Transport/*genetics
Apoptosis/*genetics
LDL-Receptor Related Proteins/*genetics
Membrane Transport Proteins/*genetics
Nerve Tissue Proteins/*genetics
Receptors, Nerve Growth Factor/*genetics
Animals ; Cell Line, Tumor ; DNA-Binding Proteins/genetics ; Gene Expression Regulation/drug effects ; Histone Deacetylase 1/genetics ; Histone Deacetylase Inhibitors/pharmacology ; Humans ; Mice ; Nerve Growth Factor/genetics ; Neuroblastoma/drug therapy ; Neuroblastoma/genetics ; Neuroblastoma/pathology ; Neurons/metabolism ; Neurons/pathology ; Primary Cell Culture ; Transcription Factors/genetics ; Valproic Acid/pharmacology
Czasopismo naukowe
Tytuł :
Evolution of delayed resistance to immunotherapy in a melanoma responder.
Autorzy :
Liu D; Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Lin JR; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA.
Robitschek EJ; Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Kasumova GG; Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.
Heyde A; Program for Evolutionary Dynamics, Harvard University, Cambridge, MA, USA.; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.
Shi A; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA, USA.
Kraya A; Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Zhang G; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA.; Preston Robert Tisch Brain Tumor Center, Department of Neurosurgery, Department of Pathology, Duke University School of Medicine, Durham, NC, USA.
Moll T; Division of Medical Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Frederick DT; Division of Medical Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Chen YA; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA.
Wang S; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA.
Schapiro D; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Ho LL; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA, USA.
Bi K; Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Sahu A; Dana-Farber Cancer Institute, Boston, MA, USA.
Mei S; Dana-Farber Cancer Institute, Boston, MA, USA.; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA.
Miao B; Division of Medical Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Sharova T; Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.
Alvarez-Breckenridge C; Department of Neurosurgery, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.
Stocking JH; Division of Medical Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Kim T; Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.
Fadden R; Division of Medical Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Lawrence D; Division of Medical Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Hoang MP; Department of Pathology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.
Cahill DP; Department of Neurosurgery, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.
Malehmir M; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.
Nowak MA; Program for Evolutionary Dynamics, Harvard University, Cambridge, MA, USA.; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.; Department of Mathematics, Harvard University, Cambridge, MA, USA.
Brastianos PK; Division of Medical Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Lian CG; Department of Pathology, Harvard Medical School, Brigham and Woman's Hospital, Boston, MA, USA.
Ruppin E; Cancer Data Science Lab, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Izar B; Division of Hematology and Oncology, Columbia University Irving Medical Center, New York, NY, USA.; Columbia Center for Translation Immunology, New York, NY, USA.
Herlyn M; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA.
Van Allen EM; Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Nathanson K; Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Basser Center for BRCA, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Flaherty KT; Division of Medical Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Sullivan RJ; Division of Medical Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Kellis M; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA, USA.
Sorger PK; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA.; Department of Systems Biology, Harvard Medical School, Cambridge, MA, USA.
Boland GM; Broad Institute of Harvard and MIT, Cambridge, MA, USA. .; Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA. .
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Źródło :
Nature medicine [Nat Med] 2021 Jun; Vol. 27 (6), pp. 985-992. Date of Electronic Publication: 2021 May 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
B7-H1 Antigen/*genetics
Immune Checkpoint Inhibitors/*therapeutic use
Melanoma/*therapy
Nerve Tissue Proteins/*genetics
Receptors, Nerve Growth Factor/*genetics
B7-H1 Antigen/antagonists & inhibitors ; B7-H1 Antigen/immunology ; Chromosomes, Human, Pair 15/genetics ; Drug Resistance, Neoplasm/drug effects ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Immune Checkpoint Inhibitors/adverse effects ; Immunotherapy/adverse effects ; Male ; Melanoma/genetics ; Melanoma/immunology ; Melanoma/pathology ; Neoplasm Metastasis ; Neoplasm Recurrence, Local/genetics ; Neoplasm Recurrence, Local/immunology ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/therapy ; Nerve Tissue Proteins/immunology ; Phylogeny ; Receptors, Nerve Growth Factor/immunology ; Tumor Microenvironment/drug effects
Czasopismo naukowe
Tytuł :
The antibiotic doxycycline mimics the NGF signaling in PC12 cells: A relevant mechanism for neuroprotection.
Autorzy :
Amaral LD; Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto - USP, Av Do Café S/n, 14040-903, Ribeirão Preto, SP, Brazil.
Santos NAGD; Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto - USP, Av Do Café S/n, 14040-903, Ribeirão Preto, SP, Brazil.
Sisti FM; Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto - USP, Av Do Café S/n, 14040-903, Ribeirão Preto, SP, Brazil.
Del Bel E; Departamento de Morfologia, Estomatologia e Fisiologia, Faculdade de Odontologia de Ribeirão Preto - USP, 14040-904, Ribeirão Preto, SP, Brazil.
Santos ACD; Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto - USP, Av Do Café S/n, 14040-903, Ribeirão Preto, SP, Brazil. Electronic address: .
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2021 May 25; Vol. 341, pp. 109454. Date of Electronic Publication: 2021 Mar 30.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Bacterial Agents/*pharmacology
Doxycycline/*pharmacology
Nerve Growth Factor/*metabolism
Animals ; Carbazoles/pharmacology ; Cell Survival/drug effects ; GAP-43 Protein/metabolism ; Indole Alkaloids/pharmacology ; MAP Kinase Signaling System/drug effects ; Nerve Growth Factor/pharmacology ; Neurofilament Proteins/metabolism ; Neuronal Outgrowth/drug effects ; Neuroprotective Agents/pharmacology ; PC12 Cells ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Receptor, trkA/antagonists & inhibitors ; Receptor, trkA/metabolism ; Signal Transduction/drug effects ; Synapsins/metabolism
Czasopismo naukowe
Tytuł :
Immunoexpression of BDNF, TrkB, and p75NTR receptors in peripheral neural lesions of the head and neck.
Autorzy :
Ribeiro JT; Department of Oral Pathology, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Thieme S; Department of Oral Pathology, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Zettermann P; Department of Oral Pathology, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Leite AA; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, SP, Brazil.
Zanella VG; Department of Oral Pathology, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.; Head and Neck Surgery Department, Hospital Santa Rita, Complexo Hospitalar Santa Casa, Porto Alegre, Brazil.
Pilar EFS; Experimental Pathology Unit, Clinics Hospital of Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Fonseca FP; Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Mesquita RA; Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Vargas PA; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, SP, Brazil.
Dos Santos JN; Department of Oral Pathology, School of Dentistry, Federal University of Bahia, Salvador, Brazil.
Martins MD; Department of Oral Pathology, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.; Head and Neck Surgery Department, Hospital Santa Rita, Complexo Hospitalar Santa Casa, Porto Alegre, Brazil.; Department of Oral Medicine, Porto Alegre Clinics Hospital (HCPA/UFRGS), Porto Alegre, Brazil.
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Źródło :
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology [J Oral Pathol Med] 2021 May; Vol. 50 (5), pp. 492-501. Date of Electronic Publication: 2020 Dec 30.
Typ publikacji :
Journal Article
MeSH Terms :
Brain-Derived Neurotrophic Factor*/metabolism
Head and Neck Neoplasms*/metabolism
Receptors, Nerve Growth Factor*/metabolism
Cross-Sectional Studies ; Down-Regulation ; Humans ; Immunohistochemistry ; Membrane Glycoproteins/metabolism ; Nerve Tissue Proteins/metabolism ; Receptor, trkB/metabolism
Czasopismo naukowe
Tytuł :
Influence of Previous COVID-19 and Mastitis Infections on the Secretion of Brain-Derived Neurotrophic Factor and Nerve Growth Factor in Human Milk.
Autorzy :
Demers-Mathieu V; Department of Neonatal Immunology and Microbiology, Medolac Laboratories A Public Benefit Corporation, Boulder City, NV 89005, USA.
Hines DJ; Department of Psychology, University of Nevada Las Vegas, Las Vegas, NV 89154, USA.
Hines RM; Department of Psychology, University of Nevada Las Vegas, Las Vegas, NV 89154, USA.
Lavangnananda S; Department of Neonatal Immunology and Microbiology, Medolac Laboratories A Public Benefit Corporation, Boulder City, NV 89005, USA.
Fels S; Department of Neonatal Immunology and Microbiology, Medolac Laboratories A Public Benefit Corporation, Boulder City, NV 89005, USA.
Medo E; Department of Neonatal Immunology and Microbiology, Medolac Laboratories A Public Benefit Corporation, Boulder City, NV 89005, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 08; Vol. 22 (8). Date of Electronic Publication: 2021 Apr 08.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Brain-Derived Neurotrophic Factor/*metabolism
COVID-19/*metabolism
Mastitis/*metabolism
Milk, Human/*chemistry
Nerve Growth Factor/*metabolism
Adult ; Bodily Secretions/chemistry ; Brain-Derived Neurotrophic Factor/analysis ; COVID-19/complications ; Female ; Humans ; Mastitis/complications ; Mothers ; Nerve Growth Factor/analysis
Czasopismo naukowe
Tytuł :
Implication of TrkC-miR2 in neurotrophin signalling pathway regulation through NGFR transcript targeting.
Autorzy :
Dokaneheifard S; Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.; Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Soltani BM; Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
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Źródło :
Journal of cellular and molecular medicine [J Cell Mol Med] 2021 Apr; Vol. 25 (7), pp. 3381-3390. Date of Electronic Publication: 2021 Mar 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Signal Transduction*
MicroRNAs/*metabolism
Nerve Growth Factors/*metabolism
Nerve Tissue Proteins/*genetics
Receptor, trkC/*genetics
Receptors, Nerve Growth Factor/*genetics
HEK293 Cells ; HeLa Cells ; Hep G2 Cells ; Humans ; MicroRNAs/genetics ; Nerve Tissue Proteins/metabolism ; Receptor, trkC/metabolism ; Receptors, Nerve Growth Factor/metabolism
Czasopismo naukowe
Tytuł :
Pleiotropic activity of nerve growth factor in regulating cardiac functions and counteracting pathogenesis.
Autorzy :
Pius-Sadowska E; Department of General Pathology, Pomeranian Medical University, Powstańców Wlkp. 72, Szczecin, 70111, Poland.
Machaliński B; Department of General Pathology, Pomeranian Medical University, Powstańców Wlkp. 72, Szczecin, 70111, Poland.
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Źródło :
ESC heart failure [ESC Heart Fail] 2021 Apr; Vol. 8 (2), pp. 974-987. Date of Electronic Publication: 2021 Jan 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Cardiovascular System*
Nerve Growth Factor*
Humans ; Myocytes, Cardiac ; Neurons ; Sympathetic Nervous System
Czasopismo naukowe
Tytuł :
Nerve growth factor regulates liver cancer cell polarity and motility.
Autorzy :
Lin H; Department of Gastroenterology, Yantian District People's Hospital, Shenzhen, Guangdong 518000, P.R. China.
Huang H; Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China.
Yu Y; Department of Gastroenterology, Yantian District People's Hospital, Shenzhen, Guangdong 518000, P.R. China.
Chen W; Department of Gastroenterology, Yantian District People's Hospital, Shenzhen, Guangdong 518000, P.R. China.
Zhang S; Department of Gastroenterology, Yantian District People's Hospital, Shenzhen, Guangdong 518000, P.R. China.
Zhang Y; Department of Gastroenterology, Yantian District People's Hospital, Shenzhen, Guangdong 518000, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2021 Apr; Vol. 23 (4). Date of Electronic Publication: 2021 Mar 02.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Cell Movement/*genetics
Cell Polarity/*genetics
Liver Neoplasms/*genetics
Nerve Growth Factor/*genetics
Anoikis/genetics ; Apoptosis/genetics ; Cell Proliferation/genetics ; Epithelial-Mesenchymal Transition/genetics ; Hep G2 Cells ; Humans ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Nerve Growth Factor/metabolism
Czasopismo naukowe
Tytuł :
Fabry disease-associated globotriaosylceramide induces mechanical allodynia via activation of signaling through proNGF-p75 but not mature NGF-TrkA.
Autorzy :
Sugimoto J; Department of Scientific Research, Fujimoto Pharmaceutical Corporation, 1-3-40 Nishiotsuka, Matsubara, Osaka, 580-8503, Japan.
Satoyoshi H; Department of Scientific Research, Fujimoto Pharmaceutical Corporation, 1-3-40 Nishiotsuka, Matsubara, Osaka, 580-8503, Japan.
Takahata K; Department of Scientific Research, Fujimoto Pharmaceutical Corporation, 1-3-40 Nishiotsuka, Matsubara, Osaka, 580-8503, Japan. Electronic address: .
Muraoka S; Department of Scientific Research, Fujimoto Pharmaceutical Corporation, 1-3-40 Nishiotsuka, Matsubara, Osaka, 580-8503, Japan.
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2021 Mar 15; Vol. 895, pp. 173882. Date of Electronic Publication: 2021 Jan 20.
Typ publikacji :
Journal Article
MeSH Terms :
Pain Threshold*/drug effects
Trihexosylceramides*
Ganglia, Spinal/*metabolism
Hyperalgesia/*metabolism
Nerve Growth Factor/*metabolism
Protein Precursors/*metabolism
Receptors, Nerve Growth Factor/*metabolism
Skin/*metabolism
Analgesics/pharmacology ; Animals ; Antibodies, Neutralizing/pharmacology ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Disease Models, Animal ; Ganglia, Spinal/physiopathology ; Hyperalgesia/chemically induced ; Hyperalgesia/physiopathology ; Hyperalgesia/prevention & control ; Male ; Membrane Microdomains/metabolism ; Mice, Inbred C57BL ; Nerve Growth Factor/antagonists & inhibitors ; Protein Precursors/antagonists & inhibitors ; Receptor, trkA/metabolism ; Receptors, Nerve Growth Factor/antagonists & inhibitors ; Signal Transduction
Czasopismo naukowe
Tytuł :
[Effects of n-hexane on learning and memory and the expressions of nerve growth factor mRNA and nerve growth factor receptor mRNA of brain tissue in mice exposed to N-hexane].
Autorzy :
Gao JF; Yishui Center Hospital of Linyi City, Yishui 276400, China.
Zhang XY; Yishui Center Hospital of Linyi City, Yishui 276400, China.
Lin Q; Yishui Center Hospital of Linyi City, Yishui 276400, China.
Chen YP; Yishui Center Hospital of Linyi City, Yishui 276400, China.
Zhang ZQ; The School of Public Health and Management, Jining Medical University, Jining 272067, China.
Lin L; The School of Public Health and Management, Jining Medical University, Jining 272067, China.
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Źródło :
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases [Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi] 2019 Mar 20; Vol. 37 (3), pp. 217-220.
Typ publikacji :
Journal Article
MeSH Terms :
Hexanes*/toxicity
Learning*/drug effects
Memory*/drug effects
Nerve Growth Factor*/drug effects
Nerve Growth Factor*/metabolism
Receptor, Nerve Growth Factor*
Animals ; Brain ; Mice ; RNA, Messenger/drug effects ; RNA, Messenger/metabolism ; Random Allocation ; Receptors, Nerve Growth Factor
Czasopismo naukowe
Tytuł :
The Biased Ligands NGF and NT-3 Differentially Stabilize Trk-A Dimers.
Autorzy :
Ahmed F; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland.
Zapata-Mercado E; Program in Molecular Biophysics, Johns Hopkins University, Baltimore, Maryland; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland.
Rahman S; Program in Molecular Biophysics, Johns Hopkins University, Baltimore, Maryland.
Hristova K; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland; Program in Molecular Biophysics, Johns Hopkins University, Baltimore, Maryland; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland. Electronic address: .
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Źródło :
Biophysical journal [Biophys J] 2021 Jan 05; Vol. 120 (1), pp. 55-63. Date of Electronic Publication: 2020 Dec 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Nerve Growth Factor*
Receptors, Nerve Growth Factor*
Cell Membrane ; Ligands ; Neurons ; Receptor, trkA
Czasopismo naukowe

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