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Wyszukujesz frazę ""NF-kappa B p50 Subunit"" wg kryterium: Temat


Tytuł :
Dll1 quiescent tumor stem cells drive chemoresistance in breast cancer through NF-κB survival pathway.
Autorzy :
Kumar S; Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Nandi A; Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Singh S; Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Regulapati R; Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Li N; Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Tobias JW; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Siebel CW; Department of Discovery Oncology, Genentech Inc., South San Francisco, CA, 94080, USA.
Blanco MA; Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Klein-Szanto AJ; Histopathology Facility, Fox Chase Cancer Center, Philadelphia, PA, USA.
Lengner C; Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Welm AL; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, 84112, USA.
Kang Y; Department of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA.
Chakrabarti R; Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA, 19104, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 18; Vol. 12 (1), pp. 432. Date of Electronic Publication: 2021 Jan 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Breast Neoplasms/*drug therapy
Calcium-Binding Proteins/*metabolism
Drug Resistance, Neoplasm/*genetics
Membrane Proteins/*metabolism
NF-kappa B p50 Subunit/*metabolism
Animals ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Benzamides/pharmacology ; Benzamides/therapeutic use ; Breast/pathology ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Calcium-Binding Proteins/antagonists & inhibitors ; Calcium-Binding Proteins/genetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Cell Survival/drug effects ; Cell Survival/genetics ; Datasets as Topic ; Disease Models, Animal ; Doxorubicin/pharmacology ; Doxorubicin/therapeutic use ; Drug Resistance, Neoplasm/drug effects ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Mice ; Mice, Knockout ; NF-kappa B p50 Subunit/antagonists & inhibitors ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism ; RNA-Seq ; Receptors, Notch/metabolism ; Signal Transduction/drug effects ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Anti-mastitis SNV identification of NFκB1 in Chinese Holstein cows and the possible anti-inflammation role of NFκB1/p105 in bovine MECs.
Autorzy :
Chen L; School of Modern Agriculture & Biotechnology, Ankang University, Ankang 725000, China.
Tian R; School of Modern Agriculture & Biotechnology, Ankang University, Ankang 725000, China.
Zhang H; College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Liu X; College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
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Źródło :
Acta biochimica et biophysica Sinica [Acta Biochim Biophys Sin (Shanghai)] 2020 Dec 11; Vol. 52 (11), pp. 1191-1201.
Typ publikacji :
Journal Article
MeSH Terms :
Mastitis, Bovine/*genetics
NF-kappa B p50 Subunit/*metabolism
Polymorphism, Single Nucleotide/*genetics
Alveolar Epithelial Cells/metabolism ; Animals ; Cattle ; Cell Line, Transformed ; China ; DNA Copy Number Variations ; Epithelial Cells/metabolism ; Female ; Gene Expression Regulation ; Genotype ; Humans ; Inflammation/genetics ; Inflammation/veterinary ; Lipopolysaccharides/toxicity ; Mammary Glands, Animal/pathology ; MicroRNAs/metabolism ; Milk/chemistry ; NF-kappa B p50 Subunit/chemistry ; NF-kappa B p50 Subunit/genetics ; Phenotype ; Ubiquitin-Protein Ligases/metabolism
Czasopismo naukowe
Tytuł :
p50 mono-ubiquitination and interaction with BARD1 regulates cell cycle progression and maintains genome stability.
Autorzy :
Wu L; Department of Surgery, Section of Neurosurgery, The University of Chicago, Chicago, IL, 60637, USA.
Crawley CD; Department of Surgery, Section of Neurosurgery, The University of Chicago, Chicago, IL, 60637, USA.
Garofalo A; Department of Surgery, Section of Neurosurgery, The University of Chicago, Chicago, IL, 60637, USA.
Nichols JW; Department of Surgery, Section of Neurosurgery, The University of Chicago, Chicago, IL, 60637, USA.
Campbell PA; Department of Surgery, Section of Neurosurgery, The University of Chicago, Chicago, IL, 60637, USA.
Khramtsova GF; Department of Medicine, The University of Chicago, Chicago, IL, 60637, USA.
Olopade OI; Department of Medicine, The University of Chicago, Chicago, IL, 60637, USA.
Weichselbaum RR; Department of Radiation and Cellular Oncology, and The Ludwig Center for Metastasis Research, The University of Chicago, Chicago, IL, 60637, USA.
Yamini B; Department of Surgery, Section of Neurosurgery, The University of Chicago, Chicago, IL, 60637, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Oct 06; Vol. 11 (1), pp. 5007. Date of Electronic Publication: 2020 Oct 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genomic Instability*
Breast Neoplasms/*metabolism
Cell Cycle/*physiology
NF-kappa B p50 Subunit/*metabolism
Tumor Suppressor Proteins/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Animals ; Binding Sites ; Breast Neoplasms/mortality ; Cell Line, Tumor ; Female ; Fibroblasts ; Humans ; Lysine/metabolism ; Mice ; NF-kappa B p50 Subunit/genetics ; Neuroblastoma/metabolism ; Protein Domains ; Protein Processing, Post-Translational ; Serine/metabolism ; Tumor Suppressor Proteins/genetics ; Ubiquitin-Protein Ligases/genetics ; Ubiquitination
Czasopismo naukowe
Tytuł :
Ultrasensitive Homogeneous Electrochemiluminescence Biosensor for a Transcription Factor Based on Target-Modulated Proximity Hybridization and Exonuclease III-Powered Recycling Amplification.
Autorzy :
Li D; Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China.
Li Y; Department of Ultrasound, Fourth People's Hospital of Taizhou City, Jianshu, 225300, China.
Luo F; Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China.; College of Biological Science and Engineering, Fuzhou University, Fuzhou, Fujian 350116, China.
Qiu B; Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China.
Lin Z; Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China.
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Źródło :
Analytical chemistry [Anal Chem] 2020 Sep 15; Vol. 92 (18), pp. 12686-12692. Date of Electronic Publication: 2020 Aug 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Nucleic Acid Amplification Techniques*
Exodeoxyribonucleases/*chemistry
NF-kappa B p50 Subunit/*genetics
Transcription Factors/*genetics
Biosensing Techniques ; DNA/chemistry ; DNA/metabolism ; Electrochemical Techniques ; Exodeoxyribonucleases/metabolism ; Humans ; Luminescent Measurements ; NF-kappa B p50 Subunit/chemistry ; NF-kappa B p50 Subunit/metabolism ; Transcription Factors/chemistry ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Rian/miR-210-3p/Nfkb1 Feedback Loop Promotes Hypoxia-Induced Cell Apoptosis in Myocardial Infarction Through Deactivating the PI3K/Akt Signaling Pathway.
Autorzy :
Zhong L; Department of Cardiology, the Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, China; and.
Jia J; Department of Cardiology, the Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, China; and.
Ye G; General Medicine, Dongguan Third People's Hospital, Dongguan, Guangzhou, China.
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Źródło :
Journal of cardiovascular pharmacology [J Cardiovasc Pharmacol] 2020 Aug; Vol. 76 (2), pp. 207-215.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
MicroRNAs/*metabolism
Myocardial Infarction/*enzymology
Myocytes, Cardiac/*enzymology
NF-kappa B p50 Subunit/*metabolism
Nuclear Proteins/*metabolism
Phosphatidylinositol 3-Kinase/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Animals ; Cell Hypoxia ; Cell Line ; Cell Proliferation ; Disease Models, Animal ; Feedback, Physiological ; Female ; Male ; Mice ; MicroRNAs/genetics ; Myocardial Infarction/genetics ; Myocardial Infarction/pathology ; Myocytes, Cardiac/pathology ; NF-kappa B p50 Subunit/genetics ; Nuclear Proteins/genetics ; Rats ; Signal Transduction
Czasopismo naukowe
Tytuł :
Tumor-Derived Prostaglandin E2 Promotes p50 NF-κB-Dependent Differentiation of Monocytic MDSCs.
Autorzy :
Porta C; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', Novara, Italy.; Center for Translational Research on Autoimmune & Allergic Diseases (CAAD) Cso Trieste 15/A, Novara, Italy.
Consonni FM; Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.
Morlacchi S; Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.
Sangaletti S; Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Bleve A; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', Novara, Italy.
Totaro MG; Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.
Larghi P; Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.
Rimoldi M; Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.
Tripodo C; Human Pathology Section, Department of Health Sciences, University of Palermo, Palermo, Italy.
Strauss L; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', Novara, Italy.
Banfi S; Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.
Storto M; Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.
Pressiani T; Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.
Rimassa L; Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.
Tartari S; Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.
Ippolito A; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', Novara, Italy.
Doni A; Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.
Soldà G; Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Duga S; Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Piccolo V; Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.
Ostuni R; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.
Natoli G; Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Bronte V; Department of Medicine, Verona University Hospital, Verona, Italy.
Balzac F; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy.
Turco E; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy.
Hirsch E; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy.
Colombo MP; Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Sica A; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', Novara, Italy. .; Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.
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Źródło :
Cancer research [Cancer Res] 2020 Jul 01; Vol. 80 (13), pp. 2874-2888. Date of Electronic Publication: 2020 Apr 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Differentiation*
Colorectal Neoplasms/*pathology
Dinoprostone/*pharmacology
Monocytes/*pathology
Myeloid-Derived Suppressor Cells/*pathology
NF-kappa B p50 Subunit/*metabolism
Pancreatic Neoplasms/*pathology
Animals ; Apoptosis ; Cell Proliferation ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/immunology ; Colorectal Neoplasms/metabolism ; Humans ; Immune Tolerance ; Interferon-gamma/metabolism ; Melanoma, Experimental/drug therapy ; Melanoma, Experimental/immunology ; Melanoma, Experimental/metabolism ; Melanoma, Experimental/pathology ; Mice ; Monocytes/drug effects ; Monocytes/immunology ; Monocytes/metabolism ; Myeloid-Derived Suppressor Cells/drug effects ; Myeloid-Derived Suppressor Cells/immunology ; Myeloid-Derived Suppressor Cells/metabolism ; NF-kappa B p50 Subunit/genetics ; Nitric Oxide/metabolism ; Oxytocics/pharmacology ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/immunology ; Pancreatic Neoplasms/metabolism ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Antibody free ELISA-like assay for the detection of transcription factors based on double-stranded DNA thermostability.
Autorzy :
Sun Y; School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, P.R. China. .
Li Z
Lau C
Lu J
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Źródło :
The Analyst [Analyst] 2020 May 07; Vol. 145 (9), pp. 3339-3344. Date of Electronic Publication: 2020 Mar 27.
Typ publikacji :
Journal Article
MeSH Terms :
Biosensing Techniques/*methods
DNA Probes/*chemistry
NF-kappa B p50 Subunit/*analysis
Binding Sites ; Cell Nucleus/metabolism ; DNA Probes/metabolism ; HeLa Cells ; Humans ; Limit of Detection ; Luminescent Measurements ; Microarray Analysis ; NF-kappa B p50 Subunit/genetics ; NF-kappa B p50 Subunit/metabolism ; Protein Binding ; Temperature
Czasopismo naukowe
Tytuł :
β-elemonic acid inhibits growth and triggers apoptosis in human castration-resistant prostate cancer cells through the suppression of JAK2/STAT3/MCL-1 and NF-ĸB signal pathways.
Autorzy :
Bao X; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China.
Zhu J; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China.
Ren C; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China.
Zhao A; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China.
Zhang M; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China.
Zhu Z; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China.
Lu X; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China.
Zhang Y; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China.
Li X; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, People's Republic of China.
Sima X; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China.
Li J; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China.
Zhang Q; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China. Electronic address: .
Ma B; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China. Electronic address: .
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2021 Jun 01; Vol. 342, pp. 109477. Date of Electronic Publication: 2021 Apr 18.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Apoptosis/*drug effects
Prostatic Neoplasms, Castration-Resistant/*drug therapy
Signal Transduction/*drug effects
Triterpenes/*therapeutic use
Animals ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Humans ; Janus Kinase 2/metabolism ; Male ; Mice, Inbred BALB C ; Myeloid Cell Leukemia Sequence 1 Protein/metabolism ; NF-kappa B p50 Subunit/metabolism ; STAT3 Transcription Factor/metabolism ; Triterpenes/pharmacology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Fluoxetine as an anti-inflammatory therapy in SARS-CoV-2 infection.
Autorzy :
Creeden JF; Department of Neurosciences, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43614, USA; Department of Cancer Biology, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43614, USA; Department of Psychiatry, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA. Electronic address: .
Imami AS; Department of Neurosciences, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43614, USA.
Eby HM; Department of Neurosciences, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43614, USA.
Gillman C; Department of Psychiatry, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.
Becker KN; Department of Cancer Biology, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43614, USA.
Reigle J; Department of Biomedical Informatics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA; Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Andari E; Department of Psychiatry, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.
Pan ZK; Department of Medical Microbiology and Immunology, University of Toledo Medical Center, Toledo, OH, USA.
O'Donovan SM; Department of Neurosciences, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43614, USA.
McCullumsmith RE; Department of Neurosciences, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43614, USA; Neurosciences Institute, ProMedica, Toledo, OH 43606, USA.
McCullumsmith CB; Department of Psychiatry, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Jun; Vol. 138, pp. 111437. Date of Electronic Publication: 2021 Feb 25.
Typ publikacji :
Journal Article
MeSH Terms :
SARS-CoV-2*
Anti-Inflammatory Agents/*therapeutic use
COVID-19/*drug therapy
Cytokine Receptor gp130/*genetics
Cytokine Release Syndrome/*drug therapy
Fluoxetine/*therapeutic use
NF-kappa B p50 Subunit/*genetics
Anti-Inflammatory Agents/pharmacology ; Fluoxetine/pharmacology ; Humans
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Can bilirubin nanomedicine become a hope for the management of COVID-19?
Autorzy :
Khurana I; Department of Pharmaceutical Chemistry, University Institute of Pharmaceutical Sciences (UIPS), Panjab University, Chandigarh 160014, India.
Allawadhi P; Department of Biotechnology, Indian Institute of Technology (IIT) Roorkee, Roorkee 247667, Uttarakhand, India. Electronic address: .
Khurana A; Centre for Biomedical Engineering (CBME), Indian Institute of Technology (IIT) Delhi, New Delhi 110016, India; Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science (CVSc), Rajendranagar, Hyderabad 500030, PVNRTVU, Telangana, India; Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science (CVSc), Warangal 506166, PVNRTVU, Telangana, India. Electronic address: .
Srivastava AK; Department of Biotechnology, Indian Institute of Technology (IIT) Roorkee, Roorkee 247667, Uttarakhand, India.
Navik U; Department of Pharmacology, School of Basic and Applied Sciences, Central University of Punjab, Bathinda 151001, Punjab, India.
Banothu AK; Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science (CVSc), Rajendranagar, Hyderabad 500030, PVNRTVU, Telangana, India; Department of Aquatic Animal Health Management, College of Fishery Science, Pebbair, Wanaparthy 509104, PVNRTVU, Telangana, India.
Bharani KK; Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science (CVSc), Warangal 506166, PVNRTVU, Telangana, India; Department of Aquatic Animal Health Management, College of Fishery Science, Pebbair, Wanaparthy 509104, PVNRTVU, Telangana, India. Electronic address: .
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Źródło :
Medical hypotheses [Med Hypotheses] 2021 Apr; Vol. 149, pp. 110534. Date of Electronic Publication: 2021 Feb 13.
Typ publikacji :
Journal Article
MeSH Terms :
Bilirubin/*therapeutic use
COVID-19/*therapy
Nanomedicine/*methods
Anti-Inflammatory Agents/therapeutic use ; Antioxidants/therapeutic use ; Antiviral Agents/therapeutic use ; Biliverdine/therapeutic use ; COVID-19/drug therapy ; Cytokine Release Syndrome ; Humans ; Inflammation ; MAP Kinase Signaling System ; Models, Theoretical ; NF-kappa B p50 Subunit/metabolism ; Risk ; Signal Transduction ; Transforming Growth Factor beta1/metabolism
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Hypomethylation of IL1RN and NFKB1 genes is linked to the dysbalance in IL1β/IL-1Ra axis in female patients with type 2 diabetes mellitus.
Autorzy :
Margaryan S; Department of Immunology, Faculty of Medicine and Dentistry, Palacký University and University Hospital Olomouc, Olomouc, Czech Republic.; Russian-Armenian (Slavonic) University, Yerevan, Armenia.; Institute of Molecular Biology, Laboratory of Molecular and Cellular Immunology, Yerevan, Armenia.
Kriegova E; Department of Immunology, Faculty of Medicine and Dentistry, Palacký University and University Hospital Olomouc, Olomouc, Czech Republic.
Fillerova R; Department of Immunology, Faculty of Medicine and Dentistry, Palacký University and University Hospital Olomouc, Olomouc, Czech Republic.
Smotkova Kraiczova V; Department of Immunology, Faculty of Medicine and Dentistry, Palacký University and University Hospital Olomouc, Olomouc, Czech Republic.
Manukyan G; Department of Immunology, Faculty of Medicine and Dentistry, Palacký University and University Hospital Olomouc, Olomouc, Czech Republic.; Russian-Armenian (Slavonic) University, Yerevan, Armenia.; Institute of Molecular Biology, Laboratory of Molecular and Cellular Immunology, Yerevan, Armenia.
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Źródło :
PloS one [PLoS One] 2020 May 29; Vol. 15 (5), pp. e0233737. Date of Electronic Publication: 2020 May 29 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Diabetes Mellitus, Type 2/*immunology
Interleukin 1 Receptor Antagonist Protein/*metabolism
Interleukin-1beta/*metabolism
NF-kappa B p50 Subunit/*metabolism
Pancreatitis, Chronic/*immunology
Adult ; Aged ; DNA Methylation ; Diabetes Mellitus, Type 2/pathology ; Female ; Humans ; Interleukin 1 Receptor Antagonist Protein/blood ; Male ; Middle Aged ; NF-kappa B p50 Subunit/blood ; Pancreatitis, Chronic/etiology ; THP-1 Cells
Czasopismo naukowe
Tytuł :
Hyperbaric Oxygen Treatment Improves Hearing Level via Attenuating TLR4/NF-κB Mediated Inflammation in Sudden Sensorineural Hearing Loss Patients.
Autorzy :
Liu XH; Department of Hyperbaric Oxygen Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Liang F; Department of Hyperbaric Oxygen Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Jia XY; Institute of Basic Medicine Sciences, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Zhao L; Department of Hyperbaric Oxygen Medicine, Beijing Pinggu Hospital, Beijing 101200, China.
Zhou Y; Institute of Basic Medicine Sciences, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Yang J; Department of Hyperbaric Oxygen Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
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Źródło :
Biomedical and environmental sciences : BES [Biomed Environ Sci] 2020 May 20; Vol. 33 (5), pp. 331-337.
Typ publikacji :
Journal Article
MeSH Terms :
Hyperbaric Oxygenation*
Hearing Loss, Sensorineural/*therapy
Hearing Loss, Sudden/*therapy
Inflammation/*therapy
NF-kappa B p50 Subunit/*genetics
Toll-Like Receptor 4/*genetics
Adolescent ; Adult ; Aged ; China ; Female ; Humans ; Inflammation/genetics ; Male ; Middle Aged ; NF-kappa B p50 Subunit/metabolism ; Toll-Like Receptor 4/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
Correlation Between Single Nucleotide Polymorphisms at the 3'-UTR of the NFKB1 Gene and Acute Kidney Injury in Sepsis.
Autorzy :
Sun J; Department of Nephrology, First People's Hospital of Yuhang District, Hangzhou, Hangzhou, Zhejiang, P.R. China.
Cai X; Department of Nephrology, First People's Hospital of Yuhang District, Hangzhou, Hangzhou, Zhejiang, P.R. China.
Shen J; Department of Nephrology, First People's Hospital of Yuhang District, Hangzhou, Hangzhou, Zhejiang, P.R. China.
Jin G; Department of Emergency, the Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, P.R. China.
Xie Q; Department of Emergency, Tiantai Hospital of Hangzhou Medical College, Tiantai, Zhejiang, P.R. China.
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Źródło :
Genetic testing and molecular biomarkers [Genet Test Mol Biomarkers] 2020 May; Vol. 24 (5), pp. 274-284. Date of Electronic Publication: 2020 Apr 21.
Typ publikacji :
Journal Article
MeSH Terms :
Acute Kidney Injury/*genetics
NF-kappa B p50 Subunit/*genetics
Sepsis/*genetics
3' Untranslated Regions/genetics ; Acute Kidney Injury/etiology ; Aged ; Alleles ; Asian Continental Ancestry Group/genetics ; China ; Female ; Genotype ; Humans ; Male ; MicroRNAs/genetics ; Middle Aged ; NF-kappa B p50 Subunit/metabolism ; Polymorphism, Single Nucleotide/genetics ; Risk Factors ; Sepsis/complications ; Tumor Necrosis Factor-alpha/genetics
Czasopismo naukowe
Tytuł :
Determination of the concentration of transcription factor by using exonuclease III-aided amplification and gold nanoparticle mediated fluorescence intensity: A new method for gene transcription related enzyme detection.
Autorzy :
Zhang K; NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu, 214063, China; Department of Radiopharmaceuticals, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China. Electronic address: .
Fan Z; NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu, 214063, China; Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing, 211816, PR China.
Li H; School of Biological Science and Technology, University of Jinan, No. 106 Jiwei Road, Jinan, Shandong, 250022, China.
Zhao J; Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing, 211816, PR China.
Xie M; NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu, 214063, China; Department of Radiopharmaceuticals, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China. Electronic address: .
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Źródło :
Analytica chimica acta [Anal Chim Acta] 2020 Apr 01; Vol. 1104, pp. 132-139. Date of Electronic Publication: 2020 Jan 03.
Typ publikacji :
Journal Article
MeSH Terms :
Biosensing Techniques/*methods
DNA Probes/*chemistry
Exodeoxyribonucleases/*chemistry
Fluorescent Dyes/*chemistry
Gold/*chemistry
Metal Nanoparticles/*chemistry
NF-kappa B p50 Subunit/*analysis
DNA Probes/genetics ; Electrophoresis, Polyacrylamide Gel ; HeLa Cells ; Humans ; Limit of Detection ; NF-kappa B p50 Subunit/genetics ; Nucleic Acid Amplification Techniques ; Oligonucleotides/chemistry
Czasopismo naukowe
Tytuł :
MicroRNA-9 ameliorates destructive arthritis through down-regulation of NF-κB1-RANKL pathway in fibroblast-like synoviocytes.
Autorzy :
Lee WS; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Yasuda S; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan; Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan. Electronic address: .
Kono M; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Kudo Y; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Shimamura S; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Kono M; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Fujieda Y; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Kato M; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Oku K; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Shimizu T; Department of Orthopedic Surgery, Faculty of Medicine, Hokkaido University, Sapporo, Japan.
Onodera T; Department of Orthopedic Surgery, Faculty of Medicine, Hokkaido University, Sapporo, Japan.
Iwasaki N; Department of Orthopedic Surgery, Faculty of Medicine, Hokkaido University, Sapporo, Japan.
Atsumi T; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
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Źródło :
Clinical immunology (Orlando, Fla.) [Clin Immunol] 2020 Mar; Vol. 212, pp. 108348. Date of Electronic Publication: 2020 Jan 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Arthritis, Experimental/*genetics
Arthritis, Rheumatoid/*genetics
Fibroblasts/*metabolism
MicroRNAs/*genetics
NF-kappa B p50 Subunit/*genetics
Osteoarthritis, Knee/*genetics
RANK Ligand/*genetics
Synoviocytes/*metabolism
Aged ; Aged, 80 and over ; Animals ; Arthritis, Experimental/metabolism ; Arthritis, Experimental/pathology ; Arthritis, Rheumatoid/metabolism ; Down-Regulation ; Female ; Gene Expression Regulation ; Humans ; Male ; MicroRNAs/metabolism ; Middle Aged ; NF-kappa B p50 Subunit/metabolism ; Osteoarthritis, Knee/metabolism ; RANK Ligand/metabolism ; Rats ; Transfection
Czasopismo naukowe
Tytuł :
Adipocyte enhancer binding protein 1 (AEBP1) knockdown suppresses human glioma cell proliferation, invasion and induces early apoptosis.
Autorzy :
Cheng L; Morphology Experiment & Training Center, School of Preclinical Medicine, Wannan Medical College, Wuhu 241002, Anhui, China.
Shao X; Department of Neurosurgery, Yijishan Hospital of Wannan Medical College, No. 2 Zheshan Road, Wuhu 241001, Anhui, China.
Wang Q; Department of Neurosurgery, Yijishan Hospital of Wannan Medical College, No. 2 Zheshan Road, Wuhu 241001, Anhui, China.
Jiang X; Department of Neurosurgery, Yijishan Hospital of Wannan Medical College, No. 2 Zheshan Road, Wuhu 241001, Anhui, China.
Dai Y; Department of Neurosurgery, Yijishan Hospital of Wannan Medical College, No. 2 Zheshan Road, Wuhu 241001, Anhui, China. Electronic address: .
Chen S; Department of Neurosurgery, Yijishan Hospital of Wannan Medical College, No. 2 Zheshan Road, Wuhu 241001, Anhui, China. Electronic address: .
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Źródło :
Pathology, research and practice [Pathol Res Pract] 2020 Feb; Vol. 216 (2), pp. 152790. Date of Electronic Publication: 2019 Dec 17.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
Gene Expression Regulation, Neoplastic*
Signal Transduction*
Carboxypeptidases/*metabolism
Glioma/*genetics
NF-kappa B p50 Subunit/*metabolism
Repressor Proteins/*metabolism
Adipocytes ; Adult ; Aged ; Carboxypeptidases/genetics ; Cell Line, Tumor ; Cell Proliferation ; Cohort Studies ; Down-Regulation ; Female ; Gene Knockdown Techniques ; Glioma/diagnosis ; Glioma/pathology ; Humans ; Male ; Middle Aged ; NF-kappa B p50 Subunit/genetics ; Neoplasm Invasiveness ; Prognosis ; Repressor Proteins/genetics ; Young Adult
Czasopismo naukowe
Tytuł :
MicroRNA-322 regulates the growth, chemosensitivity, migration and invasion of breast cancer cells by targeting NF-kB1.
Autorzy :
Hu J; Department of Pathology, Maternal and Child Health Hospital of Hubei Province, Hubei Province, China, 430070.
Guo P
Zhang Y
Huang Z
Chen B
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Źródło :
Journal of B.U.ON. : official journal of the Balkan Union of Oncology [J BUON] 2020 Jan-Feb; Vol. 25 (1), pp. 152-158.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms/*metabolism
MicroRNAs/*biosynthesis
NF-kappa B/*metabolism
NF-kappa B p50 Subunit/*metabolism
Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Movement/physiology ; Cell Proliferation/physiology ; Female ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; NF-kappa B p50 Subunit/genetics ; Neoplasm Invasiveness ; Transfection
Czasopismo naukowe
Tytuł :
Sensitive detection of transcription factor by coupled fluorescence-encoded microsphere with exonuclease protection.
Autorzy :
Sun Y; School of Biomedical Engineering, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, Guangdong, 518060, China; School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, China.
Zang L; School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, China.
Lau C; School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, China.
Zhang X; School of Biomedical Engineering, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, Guangdong, 518060, China. Electronic address: .
Lu J; School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, China. Electronic address: .
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Źródło :
Talanta [Talanta] 2021 Jul 01; Vol. 229, pp. 122272. Date of Electronic Publication: 2021 Mar 03.
Typ publikacji :
Journal Article
MeSH Terms :
Biosensing Techniques*
Microspheres*
DNA/genetics ; DNA Probes/genetics ; Exodeoxyribonucleases ; HeLa Cells ; Humans ; Limit of Detection ; NF-kappa B p50 Subunit
Czasopismo naukowe
Tytuł :
Entropy-driven electrochemiluminescence ultra-sensitive detection strategy of NF-κB p50 as the regulator of cytokine storm.
Autorzy :
Zhang K; NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu, 214063, China.
Fan Z; NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu, 214063, China.
Yao B; NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu, 214063, China; Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing, 211816, PR China.
Zhang T; Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials, School of Chemistry and Chemical Engineering, Huaiyin Normal University, Huaian, 223300, PR China.
Ding Y; NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu, 214063, China.
Zhu S; Department of Oncology, The Affiliated Wuxi No.2 People's Hospital of Nanjing Medical University, Wuxi, 214000, PR China.
Xie M; NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu, 214063, China; Department of Radiopharmaceuticals, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China. Electronic address: .
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Źródło :
Biosensors & bioelectronics [Biosens Bioelectron] 2021 Mar 15; Vol. 176, pp. 112942. Date of Electronic Publication: 2020 Dec 30.
Typ publikacji :
Journal Article
MeSH Terms :
Biosensing Techniques/*methods
COVID-19/*immunology
Cytokine Release Syndrome/*immunology
NF-kappa B p50 Subunit/*analysis
Biosensing Techniques/statistics & numerical data ; COVID-19/complications ; Cytokine Release Syndrome/etiology ; Electrochemical Techniques/methods ; Electrochemical Techniques/statistics & numerical data ; Entropy ; Humans ; Limit of Detection ; Luminescent Measurements/methods ; Luminescent Measurements/statistics & numerical data ; Pandemics ; SARS-CoV-2 ; Sensitivity and Specificity
Czasopismo naukowe
Tytuł :
The Effect of Hypoxia on the Expression of CXC Chemokines and CXC Chemokine Receptors-A Review of Literature.
Autorzy :
Korbecki J; Department of Biochemistry and Medical Chemistry, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72 Av., 70-111 Szczecin, Poland.
Kojder K; Department of Anaesthesiology and Intensive Care, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-281 Szczecin, Poland.
Kapczuk P; Department of Biochemistry and Medical Chemistry, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72 Av., 70-111 Szczecin, Poland.
Kupnicka P; Department of Biochemistry and Medical Chemistry, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72 Av., 70-111 Szczecin, Poland.
Gawrońska-Szklarz B; Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72 Av., 70-111 Szczecin, Poland.
Gutowska I; Department of Medical Chemistry, Pomeranian Medical University in Szczecin, Powstańców Wlkp. 72 Av., 70-111 Szczecin, Poland.
Chlubek D; Department of Biochemistry and Medical Chemistry, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72 Av., 70-111 Szczecin, Poland.
Baranowska-Bosiacka I; Department of Biochemistry and Medical Chemistry, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72 Av., 70-111 Szczecin, Poland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jan 15; Vol. 22 (2). Date of Electronic Publication: 2021 Jan 15.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Hypoxia*
Chemokines, CXC/*metabolism
Neoplasms/*drug therapy
Neoplasms/*metabolism
Receptors, CXCR/*metabolism
Chemotactic Factors/metabolism ; Cytokines/metabolism ; Endothelial Cells/metabolism ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Inflammation ; Microcirculation ; NF-kappa B p50 Subunit/metabolism
Czasopismo naukowe

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