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Tytuł:
Voacanga globosa Spirobisindole Alkaloids Exert Antiviral Activity in HIV Latently Infected Cell Lines by Targeting the NF-kB Cascade: In Vitro and In Silico Investigations.
Autorzy:
de Jesus MSM; The Graduate School, University of Santo Tomas, España Blvd., Manila 1015, Philippines.; Department of Biological Sciences, College of Science, University of Santo Tomas, España Blvd., Manila 1015, Philippines.
Macabeo APG; Laboratory for Organic Reactivity, Discovery and Synthesis (LORDS), Research Center for Natural and Applied Sciences, University of Santo Tomas, España Blvd., Manila 1015, Philippines.
Ramos JDA; The Graduate School, University of Santo Tomas, España Blvd., Manila 1015, Philippines.; Department of Biological Sciences, College of Science, University of Santo Tomas, España Blvd., Manila 1015, Philippines.; Molecular Diagnostics and Therapeutics Laboratory, Research Center for Natural and Applied Sciences, University of Santo Tomas, España Blvd., Manila 1015, Philippines.
de Leon VNO; Department of Biological Sciences, College of Science, University of Santo Tomas, España Blvd., Manila 1015, Philippines.; Laboratory for Organic Reactivity, Discovery and Synthesis (LORDS), Research Center for Natural and Applied Sciences, University of Santo Tomas, España Blvd., Manila 1015, Philippines.
Asamitsu K; Department of Molecular and Cellular Biology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 4678601, Japan.
Okamoto T; Department of Molecular and Cellular Biology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 4678601, Japan.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Feb 05; Vol. 27 (3). Date of Electronic Publication: 2022 Feb 05.
Typ publikacji:
Journal Article
MeSH Terms:
Alkaloids/*pharmacology
HIV Infections/*metabolism
HIV-1/*physiology
I-kappa B Kinase/*metabolism
NF-kappa B p50 Subunit/*metabolism
Transcription Factor RelA/*metabolism
Voacanga/*chemistry
Alkaloids/chemistry ; Cell Line ; Dose-Response Relationship, Drug ; HIV Infections/drug therapy ; HIV-1/drug effects ; HL-60 Cells ; Humans ; I-kappa B Kinase/chemistry ; Indole Alkaloids/pharmacology ; Models, Biological ; Molecular Docking Simulation ; NF-kappa B/metabolism ; NF-kappa B p50 Subunit/chemistry ; Plant Extracts/chemistry ; Signal Transduction/drug effects ; Spiro Compounds/pharmacology ; Transcription Factor RelA/chemistry ; Tumor Necrosis Factor-alpha/pharmacology ; Virus Latency/drug effects ; Virus Replication/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Attenuation of canonical NF-κB signaling maintains function and stability of human Treg.
Autorzy:
Ziegler LS; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
Gerner MC; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
Schmidt RLJ; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
Trapin D; Institute of Immunology, Medical University of Vienna, Vienna, Austria.
Steinberger P; Institute of Immunology, Medical University of Vienna, Vienna, Austria.
Pickl WF; Institute of Immunology, Medical University of Vienna, Vienna, Austria.
Sillaber C; Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.
Egger G; Department of Pathology, Medical University of Vienna, Vienna, Austria.; Ludwig Boltzmann Institute Applied Diagnostics, Vienna, Austria.
Schwarzinger I; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
Schmetterer KG; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
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Źródło:
The FEBS journal [FEBS J] 2021 Jan; Vol. 288 (2), pp. 640-662. Date of Electronic Publication: 2020 May 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Forkhead Transcription Factors/*immunology
Haploinsufficiency/*immunology
NF-kappa B p50 Subunit/*immunology
T-Lymphocytes, Regulatory/*immunology
TOR Serine-Threonine Kinases/*immunology
Transcription Factor RelA/*immunology
Active Transport, Cell Nucleus/drug effects ; Active Transport, Cell Nucleus/immunology ; Cell Nucleus/drug effects ; Cell Nucleus/immunology ; Cell Nucleus/metabolism ; Forkhead Transcription Factors/genetics ; Gene Expression Regulation ; Humans ; Interleukin-10/genetics ; Interleukin-10/immunology ; Lymphocyte Activation ; NF-kappa B p50 Subunit/deficiency ; NF-kappa B p50 Subunit/genetics ; Phosphorylation/drug effects ; Primary Cell Culture ; Repressor Proteins/genetics ; Repressor Proteins/immunology ; Signal Transduction ; Sirolimus/pharmacology ; T-Lymphocytes, Regulatory/cytology ; T-Lymphocytes, Regulatory/drug effects ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; TOR Serine-Threonine Kinases/genetics ; Thiazoles/pharmacology ; Transcription Factor RelA/antagonists & inhibitors ; Transcription Factor RelA/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
PCA-based unsupervised feature extraction for gene expression analysis of COVID-19 patients.
Autorzy:
Fujisawa K; School of Life Science and Technology, Tokyo Institute of Technology, Tokyo, 152-8550, Japan. .
Shimo M; Graduate School of Engineering and Science, University of the Ryukyus, Okinawa, 903-0213, Japan.
Taguchi YH; Department of Physics, Chuo University, Tokyo, 112-8551, Japan.
Ikematsu S; Department of Bioresources Engineering, National Institute of Technology, OkinawaCollege, Okinawa, 905-2192, Japan.
Miyata R; Faculty of Engineering, University of the Ryukyus, Okinawa, 903-0213, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2021 Aug 30; Vol. 11 (1), pp. 17351. Date of Electronic Publication: 2021 Aug 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Regulatory Networks*
COVID-19/*genetics
Gene Expression Profiling/*methods
Histones/*metabolism
NF-kappa B p50 Subunit/*metabolism
Transcription Factor RelA/*metabolism
Binding Sites ; COVID-19/metabolism ; Case-Control Studies ; Epigenesis, Genetic ; Gene Expression Regulation ; Genetic Predisposition to Disease ; Humans ; Machine Learning ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Orientia tsutsugamushi modulates cellular levels of NF-κB inhibitor p105.
Autorzy:
Wangsanut T; Department of Microbiology and Immunology, Virginia Commonwealth University Medical Center, School of Medicine, Richmond, Virginia, Unites States of America.
Brann KR; Department of Microbiology and Immunology, Virginia Commonwealth University Medical Center, School of Medicine, Richmond, Virginia, Unites States of America.
Adcox HE; Department of Microbiology and Immunology, Virginia Commonwealth University Medical Center, School of Medicine, Richmond, Virginia, Unites States of America.
Carlyon JA; Department of Microbiology and Immunology, Virginia Commonwealth University Medical Center, School of Medicine, Richmond, Virginia, Unites States of America.
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Źródło:
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2021 Apr 15; Vol. 15 (4), pp. e0009339. Date of Electronic Publication: 2021 Apr 15 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Bacterial Proteins/*metabolism
NF-KappaB Inhibitor alpha/*metabolism
NF-kappa B p50 Subunit/*metabolism
Orientia tsutsugamushi/*metabolism
Orientia tsutsugamushi/*pathogenicity
Transcription Factor RelA/*metabolism
Active Transport, Cell Nucleus ; Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; HeLa Cells ; Host-Pathogen Interactions/genetics ; Host-Pathogen Interactions/immunology ; Host-Pathogen Interactions/physiology ; Humans ; Orientia tsutsugamushi/immunology ; Scrub Typhus/immunology ; Scrub Typhus/microbiology ; Transcriptional Activation ; Tumor Necrosis Factor-alpha/metabolism ; Virulence/genetics ; Virulence/immunology ; Virulence/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Deregulated Levels of the NF-κB1, NF-κB2, and Rel Genes in Ukrainian Patients with Leukemia and Lymphoma in the Post-Chernobyl Period.
Autorzy:
Savlı H
Akkoyunlu RU
Çine N
Gluzman DF
Zavelevich MP
Sklyarenko LM
Koval SV
Sünnetçi D; Kocaeli University Faculty of Medicine, Department of Medical Genetics, Kocaeli, Turkey. E-mail : sun_.
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Źródło:
Turkish journal of haematology : official journal of Turkish Society of Haematology [Turk J Haematol] 2016 Mar 05; Vol. 33 (1), pp. 8-14. Date of Electronic Publication: 2015 Apr 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chernobyl Nuclear Accident*
Genes, rel*
Leukemia, Radiation-Induced/*genetics
Lymphoma/*genetics
NF-kappa B/*genetics
NF-kappa B p50 Subunit/*genetics
NF-kappa B p52 Subunit/*genetics
Neoplasms, Radiation-Induced/*genetics
Transcription Factor RelA/*genetics
Adult ; Aged ; Female ; Humans ; Leukemia, Radiation-Induced/epidemiology ; Leukemia, Radiation-Induced/etiology ; Lymphoma/epidemiology ; Lymphoma/etiology ; Lymphoma/metabolism ; Male ; Middle Aged ; Myelodysplastic Syndromes/epidemiology ; Myelodysplastic Syndromes/etiology ; Myelodysplastic Syndromes/genetics ; Myelodysplastic Syndromes/metabolism ; NF-kappa B/biosynthesis ; NF-kappa B p50 Subunit/biosynthesis ; NF-kappa B p52 Subunit/biosynthesis ; Neoplasms, Radiation-Induced/epidemiology ; Neoplasms, Radiation-Induced/etiology ; Neoplasms, Radiation-Induced/metabolism ; Real-Time Polymerase Chain Reaction ; Transcription Factor RelA/biosynthesis ; Ukraine/epidemiology ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The hormone-bound vitamin D receptor enhances the FBW7-dependent turnover of NF-κB subunits.
Autorzy:
Fekrmandi F; Departments of Medicine, McGill University, Montreal, Quebec, Canada.
Wang TT; Physiology, McGill University, Montreal, Quebec, Canada.
White JH; 1] Departments of Medicine, McGill University, Montreal, Quebec, Canada [2] Physiology, McGill University, Montreal, Quebec, Canada.
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Źródło:
Scientific reports [Sci Rep] 2015 Aug 13; Vol. 5, pp. 13002. Date of Electronic Publication: 2015 Aug 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Cycle Proteins/*genetics
F-Box Proteins/*genetics
NF-kappa B p50 Subunit/*biosynthesis
NF-kappa B p52 Subunit/*biosynthesis
Receptors, Calcitriol/*genetics
Transcription Factor RelA/*biosynthesis
Ubiquitin-Protein Ligases/*genetics
Calcitriol/genetics ; Calcitriol/metabolism ; Cell Cycle Proteins/biosynthesis ; Cell Cycle Proteins/metabolism ; F-Box Proteins/metabolism ; F-Box-WD Repeat-Containing Protein 7 ; Gene Expression Regulation ; HT29 Cells ; Hormones/metabolism ; Humans ; Microtubule-Associated Proteins/biosynthesis ; Microtubule-Associated Proteins/genetics ; NF-kappa B/biosynthesis ; NF-kappa B/genetics ; NF-kappa B p50 Subunit/genetics ; NF-kappa B p52 Subunit/genetics ; Nuclear Proteins/biosynthesis ; Nuclear Proteins/genetics ; Receptors, Calcitriol/metabolism ; Signal Transduction/drug effects ; Transcription Factor RelA/genetics ; Ubiquitin-Protein Ligases/metabolism ; Vitamin D/administration & dosage ; Vitamin D/analogs & derivatives ; Vitamin D/genetics ; Vitamin D/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
NF-κB-targeted anti-inflammatory activity of Prunella vulgaris var. lilacina in macrophages RAW 264.7.
Autorzy:
Hwang YJ; Department of Agrofood Resources, National Academy of Agricultural Science, RDA, Suwon, Gyeonggi-do 441-853, Korea. .
Lee EJ
Kim HR
Hwang KA
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2013 Oct 30; Vol. 14 (11), pp. 21489-503. Date of Electronic Publication: 2013 Oct 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Inflammation/*drug therapy
Macrophages/*drug effects
NF-kappa B p50 Subunit/*biosynthesis
Plant Extracts/*pharmacology
Transcription Factor RelA/*biosynthesis
Animals ; Dinoprostone/metabolism ; Gene Expression Regulation/drug effects ; Hexanes/chemistry ; Inflammation/chemically induced ; Inflammation/genetics ; Inflammation/pathology ; Lipopolysaccharides/toxicity ; Macrophages/metabolism ; Mice ; NF-kappa B p50 Subunit/genetics ; Nitric Oxide/metabolism ; Plant Extracts/chemistry ; Prunella/chemistry ; Solvents/chemistry ; Transcription Factor RelA/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Identification of an NF-κB p50/p65-responsive site in the human MIR155HG promoter.
Autorzy:
Thompson RC; Department of Biology, Boston University, Boston, MA 02215, USA. .
Vardinogiannis I
Gilmore TD
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Źródło:
BMC molecular biology [BMC Mol Biol] 2013 Sep 23; Vol. 14, pp. 24. Date of Electronic Publication: 2013 Sep 23.
Typ publikacji:
Journal Article; Research Support, American Recovery and Reinvestment Act; Research Support, N.I.H., Extramural
MeSH Terms:
Promoter Regions, Genetic*
MicroRNAs/*genetics
NF-kappa B p50 Subunit/*metabolism
Transcription Factor RelA/*metabolism
3T3 Cells ; Animals ; Binding Sites/genetics ; COS Cells ; Cell Line, Tumor ; Chlorocebus aethiops ; Gene Expression Regulation, Neoplastic ; Humans ; Lipopolysaccharides/immunology ; Mice ; Mice, Transgenic ; MicroRNAs/metabolism ; NF-kappa B p50 Subunit/genetics ; Signal Transduction ; Transcription Factor RelA/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Engagement of Components of DNA-Break Repair Complex and NFκB in Hsp70A1A Transcription Upregulation by Heat Shock.
Autorzy:
Hazra J; Division of Molecular Medicine, Bose Institute, P1/12, CIT Scheme VIIM, Kolkata, India.
Mukherjee P; Division of Molecular Medicine, Bose Institute, P1/12, CIT Scheme VIIM, Kolkata, India.
Ali A; Division of Molecular Medicine, Bose Institute, P1/12, CIT Scheme VIIM, Kolkata, India.
Poddar S; Bioinformatics Center, Bose Institute, P1/12, CIT Scheme VIIM, Kolkata, India.
Pal M; Division of Molecular Medicine, Bose Institute, P1/12, CIT Scheme VIIM, Kolkata, India.
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Źródło:
PloS one [PLoS One] 2017 Jan 18; Vol. 12 (1), pp. e0168165. Date of Electronic Publication: 2017 Jan 18 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
DNA Repair/*genetics
DNA Topoisomerases, Type II/*genetics
DNA-Activated Protein Kinase/*genetics
DNA-Binding Proteins/*genetics
HSP70 Heat-Shock Proteins/*genetics
NF-kappa B p50 Subunit/*genetics
Poly (ADP-Ribose) Polymerase-1/*genetics
Transcription Factor RelA/*genetics
Catalytic Domain/genetics ; Cell Line, Tumor ; DNA Breaks ; DNA-Activated Protein Kinase/metabolism ; HSP70 Heat-Shock Proteins/biosynthesis ; HeLa Cells ; Humans ; Ku Autoantigen/antagonists & inhibitors ; Poly (ADP-Ribose) Polymerase-1/metabolism ; Promoter Regions, Genetic/genetics ; RNA Interference ; RNA, Small Interfering/genetics ; Transcription, Genetic/genetics ; Up-Regulation/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A Prenylated Xanthone, Cudratricusxanthone A, Isolated from Cudrania tricuspidata Inhibits Lipopolysaccharide-Induced Neuroinflammation through Inhibition of NF-κB and p38 MAPK Pathways in BV2 Microglia.
Autorzy:
Yoon CS; Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 54538, Korea. .
Kim DC; Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 54538, Korea. .
Quang TH; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi 100000, Vietnam. .
Seo J; Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 54538, Korea. .
Kang DG; Hanbang Body-Fluid Research Center, Wonkwang University, Iksan 54538, Korea. .
Lee HS; Hanbang Body-Fluid Research Center, Wonkwang University, Iksan 54538, Korea. .
Oh H; Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 54538, Korea. .
Kim YC; Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 54538, Korea. .; Hanbang Body-Fluid Research Center, Wonkwang University, Iksan 54538, Korea. .
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2016 Sep 16; Vol. 21 (9). Date of Electronic Publication: 2016 Sep 16.
Typ publikacji:
Journal Article
MeSH Terms:
Lipopolysaccharides/*toxicity
MAP Kinase Signaling System/*drug effects
Microglia/*metabolism
Moraceae/*chemistry
NF-kappa B p50 Subunit/*metabolism
Transcription Factor RelA/*metabolism
Xanthones/*pharmacology
p38 Mitogen-Activated Protein Kinases/*metabolism
Animals ; Inflammation/chemically induced ; Inflammation/drug therapy ; Inflammation/metabolism ; Inflammation/pathology ; Mice ; Microglia/pathology ; Xanthones/chemistry ; Xanthones/isolation & purification
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
PAFR activation of NF-κB p65 or p105 precursor dictates pro- and anti-inflammatory responses during TLR activation in murine macrophages.
Autorzy:
Ishizuka EK; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Filgueiras LR; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Rios FJ; Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom.
Serezani CH; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, (46202) United States of America.
Jancar S; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
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Źródło:
Scientific reports [Sci Rep] 2016 Aug 24; Vol. 6, pp. 32092. Date of Electronic Publication: 2016 Aug 24.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Inflammation/*metabolism
NF-kappa B p50 Subunit/*metabolism
Platelet Membrane Glycoproteins/*metabolism
Receptors, G-Protein-Coupled/*metabolism
Toll-Like Receptors/*metabolism
Transcription Factor RelA/*metabolism
Animals ; Cytokines/metabolism ; Inflammation Mediators/metabolism ; Interleukin-10/metabolism ; Lipopolysaccharides/pharmacology ; Lipoproteins/pharmacology ; Macrophages, Peritoneal/drug effects ; Macrophages, Peritoneal/metabolism ; Macrophages, Peritoneal/pathology ; Male ; Mice, Inbred C57BL ; Myeloid Differentiation Factor 88/genetics ; Myeloid Differentiation Factor 88/metabolism ; Platelet Activating Factor/metabolism ; Platelet Activating Factor/pharmacology ; Toll-Like Receptor 2/metabolism ; Toll-Like Receptor 4/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Cautionary notes on the use of NF-κB p65 and p50 antibodies for CNS studies.
Autorzy:
Herkenham M; Section on Functional Neuroanatomy, Laboratory of Cellular & Molecular Regulation, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA. />Rathore P
Brown P
Listwak SJ
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Źródło:
Journal of neuroinflammation [J Neuroinflammation] 2011 Oct 14; Vol. 8, pp. 141. Date of Electronic Publication: 2011 Oct 14.
Typ publikacji:
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Antibody Specificity*
Antibodies/*metabolism
Immunohistochemistry/*methods
NF-kappa B p50 Subunit/*metabolism
Transcription Factor RelA/*metabolism
Animals ; Hippocampus/cytology ; Hippocampus/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; NF-kappa B p50 Subunit/genetics ; Neurons/cytology ; Neurons/metabolism ; Transcription Factor RelA/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Impact of short-term systemic hypoxia on phagocytosis, cytokine production, and transcription factor activation in peripheral blood cells.
Autorzy:
Fritzenwanger M; Department of Internal Medicine I, Division of Cardiology, Friedrich-Schiller-University, Erlanger Allee 101, 07740 Jena, Germany. />Jung C
Goebel B
Lauten A
Figulla HR
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Źródło:
Mediators of inflammation [Mediators Inflamm] 2011; Vol. 2011, pp. 429501. Date of Electronic Publication: 2011 Jun 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cytokines/*immunology
Hypoxia/*immunology
Hypoxia-Inducible Factor 1, alpha Subunit/*immunology
NF-kappa B p50 Subunit/*immunology
Phagocytosis/*immunology
Transcription Factor RelA/*immunology
Adult ; Atmospheric Pressure ; CD4-Positive T-Lymphocytes/physiology ; Cytokines/genetics ; Erythropoietin/blood ; Female ; Fluorescein-5-isothiocyanate ; Fluorescent Dyes ; Humans ; Hypoxia/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/blood ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Lactic Acid/blood ; Male ; Monocytes/physiology ; NF-kappa B p50 Subunit/genetics ; Neutrophils/physiology ; Phagocytosis/genetics ; Transcription Factor RelA/genetics ; Vascular Endothelial Growth Factor A/blood ; Young Adult ; Zymosan/immunology ; Zymosan/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
miR-508-3p concordantly silences NFKB1 and RELA to inactivate canonical NF-κB signaling in gastric carcinogenesis.
Autorzy:
Huang T; Department of Anatomical and Cellular Pathology, State Key Laboratory in Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, SAR, PR China. .; Institute of Digestive Disease, Partner State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, SAR, PR China. .; Li Ka Shing Institute of Health Science, Sir Y.K. Pao Cancer Center, The Chinese University of Hong Kong, Hong Kong, SAR, PR China. .; Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, PR China. .
Kang W; Department of Anatomical and Cellular Pathology, State Key Laboratory in Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, SAR, PR China. .; Institute of Digestive Disease, Partner State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, SAR, PR China. .; Li Ka Shing Institute of Health Science, Sir Y.K. Pao Cancer Center, The Chinese University of Hong Kong, Hong Kong, SAR, PR China. .; Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, PR China. .
Zhang B; Department of Gastroenterology, The Affiliated Drum Tower Hospital of Nanjing University, Medical School, Nanjing, PR China. .
Wu F; Department of Anatomical and Cellular Pathology, State Key Laboratory in Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, SAR, PR China. .; Institute of Digestive Disease, Partner State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, SAR, PR China. .; Li Ka Shing Institute of Health Science, Sir Y.K. Pao Cancer Center, The Chinese University of Hong Kong, Hong Kong, SAR, PR China. .
Dong Y; Institute of Digestive Disease, Partner State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, SAR, PR China. .; Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, PR China. .
Tong JH; Department of Anatomical and Cellular Pathology, State Key Laboratory in Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, SAR, PR China. .; Institute of Digestive Disease, Partner State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, SAR, PR China. .; Li Ka Shing Institute of Health Science, Sir Y.K. Pao Cancer Center, The Chinese University of Hong Kong, Hong Kong, SAR, PR China. .
Yang W; Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, PR China. .; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, PR China. .
Zhou Y; Department of Anatomical and Cellular Pathology, State Key Laboratory in Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, SAR, PR China. .; Institute of Digestive Disease, Partner State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, SAR, PR China. .; Li Ka Shing Institute of Health Science, Sir Y.K. Pao Cancer Center, The Chinese University of Hong Kong, Hong Kong, SAR, PR China. .
Zhang L; Department of Anatomical and Cellular Pathology, State Key Laboratory in Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, SAR, PR China. .; Institute of Digestive Disease, Partner State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, SAR, PR China. .; Li Ka Shing Institute of Health Science, Sir Y.K. Pao Cancer Center, The Chinese University of Hong Kong, Hong Kong, SAR, PR China. .
Cheng AS; Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, PR China. .; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, PR China. .
Yu J; Institute of Digestive Disease, Partner State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, SAR, PR China. .; Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, PR China. .; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, PR China. .
To KF; Department of Anatomical and Cellular Pathology, State Key Laboratory in Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, SAR, PR China. .; Institute of Digestive Disease, Partner State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, SAR, PR China. .; Li Ka Shing Institute of Health Science, Sir Y.K. Pao Cancer Center, The Chinese University of Hong Kong, Hong Kong, SAR, PR China. .; Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, PR China. .
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Źródło:
Molecular cancer [Mol Cancer] 2016 Jan 22; Vol. 15, pp. 9. Date of Electronic Publication: 2016 Jan 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Silencing*
Signal Transduction*/genetics
Carcinogenesis/*genetics
MicroRNAs/*metabolism
NF-kappa B p50 Subunit/*metabolism
Stomach Neoplasms/*genetics
Stomach Neoplasms/*pathology
Transcription Factor RelA/*metabolism
Base Sequence ; Carcinogenesis/pathology ; Cell Line, Tumor ; Down-Regulation/genetics ; Female ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Humans ; Male ; MicroRNAs/genetics ; Middle Aged ; Molecular Sequence Data ; Multivariate Analysis ; Proportional Hazards Models ; Up-Regulation/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The Inflammatory Transcription Factors NFκB, STAT1 and STAT3 Drive Age-Associated Transcriptional Changes in the Human Kidney.
Autorzy:
O'Brown ZK; Department of Developmental Biology, Stanford University, Stanford, California, United States of America.; Department of Genetics, Stanford University, Stanford, California, United States of America.; Cancer Biology Program, Stanford University, Stanford, California, United States of America.
Van Nostrand EL; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California, United States of America.
Higgins JP; Department of Pathology, Stanford University Medical Center, Stanford, California, United States of America.
Kim SK; Department of Developmental Biology, Stanford University, Stanford, California, United States of America.; Department of Genetics, Stanford University, Stanford, California, United States of America.
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Źródło:
PLoS genetics [PLoS Genet] 2015 Dec 17; Vol. 11 (12), pp. e1005734. Date of Electronic Publication: 2015 Dec 17 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
NF-kappa B/*genetics
NF-kappa B p50 Subunit/*genetics
Renal Insufficiency, Chronic/*genetics
STAT1 Transcription Factor/*biosynthesis
STAT3 Transcription Factor/*biosynthesis
Transcription Factor RelA/*genetics
Aging/genetics ; Aging/pathology ; Genetic Association Studies ; Humans ; Inflammation/genetics ; Inflammation/pathology ; Interferon-gamma/genetics ; Interferon-gamma/metabolism ; Interleukin-6 ; Renal Insufficiency, Chronic/pathology ; STAT1 Transcription Factor/genetics ; STAT3 Transcription Factor/genetics ; Transcription, Genetic ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The NF-κB p65 and p50 homodimer cooperate with IRF8 to activate iNOS transcription.
Autorzy:
Simon PS; Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Regents University, Augusta, GA, 30912, USA. .; Cancer Center, Georgia Regents University, Augusta, GA, 30912, USA. .; Charlie Norwood VA Medical Center, Augusta, GA, 30904, USA. .
Sharman SK; Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Regents University, Augusta, GA, 30912, USA. .; Cancer Center, Georgia Regents University, Augusta, GA, 30912, USA. .
Lu C; Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Regents University, Augusta, GA, 30912, USA. .; Charlie Norwood VA Medical Center, Augusta, GA, 30904, USA. .
Yang D; Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Regents University, Augusta, GA, 30912, USA. .; Charlie Norwood VA Medical Center, Augusta, GA, 30904, USA. .
Paschall AV; Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Regents University, Augusta, GA, 30912, USA. .; Cancer Center, Georgia Regents University, Augusta, GA, 30912, USA. .; Charlie Norwood VA Medical Center, Augusta, GA, 30904, USA. .
Tulachan SS; Medicine, Medical College of Georgia, Georgia Regents University, Augusta, GA, 30912, USA. .
Liu K; Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Regents University, Augusta, GA, 30912, USA. .; Cancer Center, Georgia Regents University, Augusta, GA, 30912, USA. .; Charlie Norwood VA Medical Center, Augusta, GA, 30904, USA. .
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Źródło:
BMC cancer [BMC Cancer] 2015 Oct 23; Vol. 15, pp. 770. Date of Electronic Publication: 2015 Oct 23.
Typ publikacji:
Journal Article
MeSH Terms:
Colonic Neoplasms/*metabolism
Interferon Regulatory Factors/*physiology
NF-kappa B p50 Subunit/*metabolism
Nitric Oxide Synthase Type II/*metabolism
Transcription Factor RelA/*physiology
Animals ; Cell Line, Tumor/metabolism ; Colon/metabolism ; Humans ; Interferon Regulatory Factors/metabolism ; Interferon-gamma/physiology ; Mice ; Myeloid Cells/metabolism ; Promoter Regions, Genetic ; Tumor Microenvironment/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Enterovirus 71 2C Protein Inhibits NF-κB Activation by Binding to RelA(p65).
Autorzy:
Du H; MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing 100176, PR China.
Yin P; MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing 100176, PR China.
Yang X; MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing 100176, PR China.
Zhang L; MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing 100176, PR China.
Jin Q; MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing 100176, PR China.
Zhu G; Shanghai Municipal Center for Disease Control &Prevention, Shanghai 200336, China.
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Źródło:
Scientific reports [Sci Rep] 2015 Sep 23; Vol. 5, pp. 14302. Date of Electronic Publication: 2015 Sep 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Carrier Proteins/*metabolism
Enterovirus A, Human/*metabolism
Immune Evasion/*immunology
NF-kappa B p50 Subunit/*metabolism
Transcription Factor RelA/*metabolism
Viral Nonstructural Proteins/*metabolism
Binding Sites/genetics ; Cell Line, Tumor ; Enzyme Activation ; HEK293 Cells ; Humans ; I-kappa B Kinase/metabolism ; Immune Evasion/physiology ; Protein Binding/physiology ; Saccharomyces cerevisiae/genetics ; Two-Hybrid System Techniques
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Effect of natural and semisynthetic pseudoguianolides on the stability of NF-κB:DNA complex studied by agarose gel electrophoresis.
Autorzy:
Villagomez R; Centre for Analysis and Synthesis, Lund University, P.O. Box 124, 221 00 Lund, Sweden; Instituto de Investigaciones Químicas, Facultad de Ciencias Puras y Naturales, Universidad Mayor de San Andrés, P.O. Box 303 La Paz, Bolivia.
Hatti-Kaul R; Biotechnology, Dept. of Chemistry, Lund University, P.O. Box 124, SE-22 100 Lund, Sweden.
Sterner O; Centre for Analysis and Synthesis, Lund University, P.O. Box 124, 221 00 Lund, Sweden.
Almanza G; Instituto de Investigaciones Químicas, Facultad de Ciencias Puras y Naturales, Universidad Mayor de San Andrés, P.O. Box 303 La Paz, Bolivia.
Linares-Pastén JA; Biotechnology, Dept. of Chemistry, Lund University, P.O. Box 124, SE-22 100 Lund, Sweden.
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Źródło:
PloS one [PLoS One] 2015 Jan 23; Vol. 10 (1), pp. e0115819. Date of Electronic Publication: 2015 Jan 23 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Inverted Repeat Sequences*
DNA/*chemical synthesis
NF-kappa B p50 Subunit/*chemistry
Transcription Factor RelA/*chemistry
Electrophoresis, Agar Gel ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 30

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