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Tytuł :
Extracellular signal-regulated kinase 1/2 regulates NAD metabolism during acute kidney injury through microRNA-34a-mediated NAMPT expression.
Autorzy :
Collier JB; Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, SC, USA. .; Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA. .; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, USA. .
Schnellmann RG; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, USA.; Southern Arizona VA Health Care System, Tucson, AZ, USA.; Southwest Environmental Health Science Center, University of Arizona, Tucson, AZ, USA.
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2020 Sep; Vol. 77 (18), pp. 3643-3655. Date of Electronic Publication: 2019 Dec 23.
Typ publikacji :
Journal Article
MeSH Terms :
Acute Kidney Injury/*pathology
Cytokines/*metabolism
MicroRNAs/*metabolism
Mitogen-Activated Protein Kinase 1/*metabolism
Mitogen-Activated Protein Kinase 3/*metabolism
NAD/*metabolism
Nicotinamide Phosphoribosyltransferase/*metabolism
Acetylation/drug effects ; Acute Kidney Injury/metabolism ; Animals ; Antagomirs/metabolism ; Creatinine/blood ; Cytokines/genetics ; Disease Models, Animal ; Gene Expression Regulation/drug effects ; Kidney Cortex/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; MicroRNAs/antagonists & inhibitors ; MicroRNAs/genetics ; Mitogen-Activated Protein Kinase 1/antagonists & inhibitors ; Mitogen-Activated Protein Kinase 3/antagonists & inhibitors ; Nicotinamide Phosphoribosyltransferase/genetics ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism ; Phosphorylation/drug effects ; Pyridones/pharmacology ; Pyrimidinones/pharmacology ; Sirtuin 1/metabolism
Czasopismo naukowe
Tytuł :
Effect of Phosphoribosyltransferase Down-regulation on Malignant Glioma Cell Characteristics.
Autorzy :
Kamada M; Division of Molecular Genetics, Core Research Facilities for Basic Science, Research Center for Medical Sciences, The Jikei University School of Medicine, Tokyo, Japan .; Division of Molecular Cell Biology, Core Research Facilities for Basic Science, Research Center for Medical Sciences, The Jikei University School of Medicine, Tokyo, Japan.
Ikeda K; Division of Molecular Cell Biology, Core Research Facilities for Basic Science, Research Center for Medical Sciences, The Jikei University School of Medicine, Tokyo, Japan.
Manome Y; Division of Molecular Cell Biology, Core Research Facilities for Basic Science, Research Center for Medical Sciences, The Jikei University School of Medicine, Tokyo, Japan.
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Źródło :
Anticancer research [Anticancer Res] 2020 Sep; Vol. 40 (9), pp. 4895-4905.
Typ publikacji :
Journal Article
MeSH Terms :
Down-Regulation*
Cytokines/*metabolism
Glioma/*enzymology
Nicotinamide Phosphoribosyltransferase/*metabolism
Antineoplastic Agents, Alkylating/pharmacology ; Cell Line, Tumor ; Cell Proliferation ; Cytokines/genetics ; Glioma/metabolism ; Glioma/pathology ; Humans ; NAD/metabolism ; Nicotinamide Phosphoribosyltransferase/genetics ; Pentosyltransferases/genetics ; Pentosyltransferases/metabolism ; RNA, Small Interfering/genetics ; Temozolomide/pharmacology
Czasopismo naukowe
Tytuł :
Nicotinamide N-methyltransferase decreases 5-fluorouracil sensitivity in human esophageal squamous cell carcinoma through metabolic reprogramming and promoting the Warburg effect.
Autorzy :
Cui Y; School of Life Sciences, Zhengzhou University, Zhengzhou.
Yang D; Zhongyuan Academy of Biological Medicine, Liaocheng People's Hospital, Liaocheng, China.
Wang W; School of Life Sciences, Zhengzhou University, Zhengzhou.
Zhang L; School of Life Sciences, Zhengzhou University, Zhengzhou.
Liu H; School of Life Sciences, Zhengzhou University, Zhengzhou.
Ma S; School of Life Sciences, Zhengzhou University, Zhengzhou.
Guo W; School of Life Sciences, Zhengzhou University, Zhengzhou.
Yao M; School of Life Sciences, Zhengzhou University, Zhengzhou.
Zhang K; School of Life Sciences, Zhengzhou University, Zhengzhou.
Li W; Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Zhang Y; School of Life Sciences, Zhengzhou University, Zhengzhou.
Guan F; School of Life Sciences, Zhengzhou University, Zhengzhou.; Clinical Research Guidance Center, Henan Provincial People's Hospital, Zhengzhou, China.
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Źródło :
Molecular carcinogenesis [Mol Carcinog] 2020 Aug; Vol. 59 (8), pp. 940-954. Date of Electronic Publication: 2020 May 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cellular Reprogramming*
Drug Resistance, Neoplasm*
Esophageal Squamous Cell Carcinoma/*pathology
Fluorouracil/*pharmacology
Glycolysis/*drug effects
Metabolome/*drug effects
Nicotinamide N-Methyltransferase/*metabolism
Animals ; Antimetabolites, Antineoplastic/pharmacology ; Apoptosis ; Biomarkers, Tumor ; Cell Proliferation ; Esophageal Neoplasms/drug therapy ; Esophageal Neoplasms/genetics ; Esophageal Neoplasms/metabolism ; Esophageal Neoplasms/pathology ; Esophageal Squamous Cell Carcinoma/drug therapy ; Esophageal Squamous Cell Carcinoma/genetics ; Esophageal Squamous Cell Carcinoma/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Nicotinamide N-Methyltransferase/genetics ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Glucose availability regulates nicotinamide N-methyltransferase expression in adipocytes.
Autorzy :
Ehebauer F; Universitätsklinikum Würzburg, Medizinische Klinik und Poliklinik I, Oberdürrbacher Str. 6, 97080 Würzburg, Germany.
Ghavampour S; Universitätsklinikum Würzburg, Medizinische Klinik und Poliklinik I, Oberdürrbacher Str. 6, 97080 Würzburg, Germany.
Kraus D; Universitätsklinikum Würzburg, Medizinische Klinik und Poliklinik I, Oberdürrbacher Str. 6, 97080 Würzburg, Germany. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 May 01; Vol. 248, pp. 117474. Date of Electronic Publication: 2020 Feb 27.
Typ publikacji :
Journal Article
MeSH Terms :
Adipocytes/*drug effects
Glucose/*pharmacology
Glucose Transporter Type 4/*genetics
Nicotinamide N-Methyltransferase/*genetics
TOR Serine-Threonine Kinases/*genetics
3T3-L1 Cells ; AMP-Activated Protein Kinases/genetics ; AMP-Activated Protein Kinases/metabolism ; Adipocytes/cytology ; Adipocytes/metabolism ; Animals ; Autophagy/drug effects ; Autophagy/genetics ; Biological Transport/drug effects ; Cell Differentiation ; Deoxyglucose/pharmacology ; Energy Metabolism/genetics ; Gene Expression Regulation ; Glucose/metabolism ; Glucose Transporter Type 4/antagonists & inhibitors ; Glucose Transporter Type 4/metabolism ; Glucose-6-Phosphate Isomerase/antagonists & inhibitors ; Glucose-6-Phosphate Isomerase/genetics ; Glucose-6-Phosphate Isomerase/metabolism ; Homeostasis/genetics ; Mice ; Morpholines/pharmacology ; Nicotinamide N-Methyltransferase/antagonists & inhibitors ; Nicotinamide N-Methyltransferase/metabolism ; Pentose Phosphate Pathway/drug effects ; Pentose Phosphate Pathway/genetics ; Phloretin/pharmacology ; Protein Biosynthesis ; RNA, Messenger/antagonists & inhibitors ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; TOR Serine-Threonine Kinases/metabolism ; Triazines/pharmacology
Czasopismo naukowe
Tytuł :
Intracellular cAMP contents regulate NAMPT expression via induction of C/EBPβ in adipocytes.
Autorzy :
Mitani T; Graduate School of Science and Technology, Department of Agriculture, Division of Food Science and Biotechnology, Shinshu University, Kami-ina, Nagano, Japan. Electronic address: .
Watanabe S; Graduate School of Science and Technology, Department of Agriculture, Division of Food Science and Biotechnology, Shinshu University, Kami-ina, Nagano, Japan.
Wada K; Department of Bioscience and Biotechnology, Shinshu University, Kami-ina, Nagano, Japan.
Fujii H; Graduate School of Science and Technology, Department of Biomedical Engineering, Shinshu University, Kami-ina, Nagano, Japan; Department of Biomolecular Innovation, Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University, Kami-ina, Nagano, Japan.
Nakamura S; Graduate School of Science and Technology, Department of Agriculture, Division of Food Science and Biotechnology, Shinshu University, Kami-ina, Nagano, Japan.
Katayama S; Graduate School of Science and Technology, Department of Agriculture, Division of Food Science and Biotechnology, Shinshu University, Kami-ina, Nagano, Japan; Department of Biomolecular Innovation, Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University, Kami-ina, Nagano, Japan.
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Feb 12; Vol. 522 (3), pp. 770-775. Date of Electronic Publication: 2019 Nov 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adipocytes/*metabolism
CCAAT-Enhancer-Binding Protein-beta/*genetics
Cyclic AMP/*metabolism
Cytokines/*genetics
Nicotinamide Phosphoribosyltransferase/*genetics
3T3-L1 Cells ; Adipocytes/cytology ; Adipogenesis ; Animals ; CCAAT-Enhancer-Binding Protein-beta/metabolism ; Cytokines/metabolism ; Gene Expression Regulation ; Mice ; Nicotinamide Phosphoribosyltransferase/metabolism ; Promoter Regions, Genetic
Czasopismo naukowe
Tytuł :
Nicotinamide phosphoribosyltransferase‑related signaling pathway in early Alzheimer's disease mouse models.
Autorzy :
Xing S; Shanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200031, P.R. China.
Hu Y; Shanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200031, P.R. China.
Huang X; Shanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200031, P.R. China.
Shen D; Shanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200031, P.R. China.
Chen C; Shanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200031, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2019 Dec; Vol. 20 (6), pp. 5163-5171. Date of Electronic Publication: 2019 Oct 30.
Typ publikacji :
Journal Article
MeSH Terms :
Acrylamides/*antagonists & inhibitors
Alzheimer Disease/*metabolism
Cytokines/*drug effects
Cytokines/*metabolism
NAD/*antagonists & inhibitors
Nicotinamide Phosphoribosyltransferase/*drug effects
Nicotinamide Phosphoribosyltransferase/*metabolism
Piperidines/*antagonists & inhibitors
Signal Transduction/*physiology
Acrylamides/pharmacology ; Amyloid/metabolism ; Animals ; Behavior, Animal ; Cytokines/genetics ; Disease Models, Animal ; Hippocampus/drug effects ; Learning/drug effects ; Male ; Memory/drug effects ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; NAD/metabolism ; NAD/pharmacology ; Nicotinamide Phosphoribosyltransferase/genetics ; Piperidines/pharmacology ; Sirtuin 1/metabolism
Czasopismo naukowe
Tytuł :
Pharmacological bypass of NAD salvage pathway protects neurons from chemotherapy-induced degeneration.
Autorzy :
Liu HW; Vollum Institute, Oregon Health & Science University, Portland, OR 97239.
Smith CB; Vollum Institute, Oregon Health & Science University, Portland, OR 97239.
Schmidt MS; Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 55242.
Cambronne XA; Vollum Institute, Oregon Health & Science University, Portland, OR 97239.
Cohen MS; Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, OR 97239.
Migaud ME; Mitchell Cancer Institute, University of South Alabama, Mobile, AL 33604.
Brenner C; Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 55242; .
Goodman RH; Vollum Institute, Oregon Health & Science University, Portland, OR 97239; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Oct 16; Vol. 115 (42), pp. 10654-10659. Date of Electronic Publication: 2018 Sep 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Acrylamides/*pharmacology
NAD/*metabolism
Nerve Degeneration/*prevention & control
Neurons/*drug effects
Niacinamide/*analogs & derivatives
Nicotinamide Mononucleotide/*analogs & derivatives
Piperidines/*pharmacology
Vincristine/*toxicity
Animals ; Antineoplastic Agents, Phytogenic/toxicity ; Drug Combinations ; Francisella tularensis/enzymology ; Ganglia, Spinal/drug effects ; Ganglia, Spinal/metabolism ; Ganglia, Spinal/pathology ; Nerve Degeneration/chemically induced ; Nerve Degeneration/metabolism ; Neurons/metabolism ; Neurons/pathology ; Niacinamide/pharmacology ; Nicotinamide Mononucleotide/metabolism ; Nicotinamide Phosphoribosyltransferase/antagonists & inhibitors ; Nicotinamide Phosphoribosyltransferase/metabolism
Czasopismo naukowe
Tytuł :
Nicotinamide mononucleotide preserves mitochondrial function and increases survival in hemorrhagic shock.
Autorzy :
Sims CA; Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; The Trauma Center at Penn, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Penn Acute Research Collaboration (PARC) and.
Guan Y; The Trauma Center at Penn, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Mukherjee S; Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Singh K; The Trauma Center at Penn, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Botolin P; The Trauma Center at Penn, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Davila A Jr; Penn Acute Research Collaboration (PARC) and.
Baur JA; Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
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Źródło :
JCI insight [JCI Insight] 2018 Sep 06; Vol. 3 (17). Date of Electronic Publication: 2018 Sep 06 (Print Publication: 2018).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Mitochondria/*drug effects
Mitochondria/*metabolism
NAD/*metabolism
Nicotinamide Mononucleotide/*pharmacology
Shock, Hemorrhagic/*prevention & control
Acidosis, Lactic/blood ; Adenosine Triphosphate ; Animals ; Cytokines/metabolism ; Hepatocytes/metabolism ; Humans ; Inflammation ; Interleukin-6/blood ; Kidney/drug effects ; Liver/drug effects ; Male ; Mitochondrial Diseases/prevention & control ; Nicotinamide Phosphoribosyltransferase/metabolism ; Nicotinamide-Nucleotide Adenylyltransferase/metabolism ; Rats ; Resuscitation ; Shock, Hemorrhagic/mortality ; Survival Analysis
Czasopismo naukowe
Tytuł :
NAMPT Inhibition Suppresses Cancer Stem-like Cells Associated with Therapy-Induced Senescence in Ovarian Cancer.
Autorzy :
Nacarelli T; Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania.
Fukumoto T; Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania.
Zundell JA; Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania.
Fatkhutdinov N; Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania.
Jean S; Helen F. Graham Cancer Center & Research Institute, Newark, Delaware.
Cadungog MG; Helen F. Graham Cancer Center & Research Institute, Newark, Delaware.
Borowsky ME; Helen F. Graham Cancer Center & Research Institute, Newark, Delaware.
Zhang R; Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania. .
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Źródło :
Cancer research [Cancer Res] 2020 Feb 15; Vol. 80 (4), pp. 890-900. Date of Electronic Publication: 2019 Dec 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Carcinoma, Ovarian Epithelial/*drug therapy
Cytokines/*antagonists & inhibitors
Neoplastic Stem Cells/*drug effects
Nicotinamide Phosphoribosyltransferase/*antagonists & inhibitors
Ovarian Neoplasms/*drug therapy
Acrylamides/pharmacology ; Acrylamides/therapeutic use ; Aldehyde Dehydrogenase 1/metabolism ; Animals ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carcinoma, Ovarian Epithelial/pathology ; Cell Line, Tumor ; Cellular Senescence/drug effects ; Cisplatin/pharmacology ; Cisplatin/therapeutic use ; Cytokines/metabolism ; Drug Resistance, Neoplasm/drug effects ; Female ; Humans ; Mice ; Neoplastic Stem Cells/pathology ; Nicotinamide Phosphoribosyltransferase/metabolism ; Ovarian Neoplasms/pathology ; Piperidines/pharmacology ; Piperidines/therapeutic use ; Retinal Dehydrogenase/metabolism ; Spheroids, Cellular ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Development of a Bioluminescent High-Throughput Screening Assay for Nicotinamide Mononucleotide Adenylyltransferase (NMNAT).
Autorzy :
Haubrich BA; Institute for Rare and Neglected Diseases Drug Discovery, Mountain View, CA, USA.; Department of Chemistry, University of Nevada, Reno, Reno, NV, USA.
Ramesha C; Institute for Rare and Neglected Diseases Drug Discovery, Mountain View, CA, USA.
Swinney DC; Institute for Rare and Neglected Diseases Drug Discovery, Mountain View, CA, USA.; DCSwinney Consulting, Belmont, CA, USA.
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Źródło :
SLAS discovery : advancing life sciences R & D [SLAS Discov] 2020 Jan; Vol. 25 (1), pp. 33-42. Date of Electronic Publication: 2019 Oct 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Enzyme Assays/*methods
High-Throughput Screening Assays/*methods
Luminescent Measurements/*methods
Nicotinamide-Nucleotide Adenylyltransferase/*metabolism
Adenosine Triphosphate/metabolism ; Dose-Response Relationship, Drug ; Enzyme Activation/drug effects ; Gene Expression ; Genes, Reporter ; Humans ; Kinetics ; Metabolic Networks and Pathways ; NAD/metabolism ; Nicotinamide-Nucleotide Adenylyltransferase/chemistry
Czasopismo naukowe
Tytuł :
Engineering a nicotinamide mononucleotide redox cofactor system for biocatalysis.
Autorzy :
Black WB; Department of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, CA, USA.
Zhang L; Department of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, CA, USA.
Mak WS; Department of Chemistry, University of California, Davis, Davis, CA, USA.; Genome Center, University of California, Davis, Davis, CA, USA.
Maxel S; Department of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, CA, USA.
Cui Y; Department of Chemistry, University of California, Davis, Davis, CA, USA.; Genome Center, University of California, Davis, Davis, CA, USA.
King E; Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA.
Fong B; Department of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, CA, USA.
Sanchez Martinez A; Department of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, CA, USA.
Siegel JB; Department of Chemistry, University of California, Davis, Davis, CA, USA. .; Genome Center, University of California, Davis, Davis, CA, USA. .; Department of Biochemistry and Molecular Medicine, University of California, Davis, Davis, CA, USA. .
Li H; Department of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, CA, USA. .
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Źródło :
Nature chemical biology [Nat Chem Biol] 2020 Jan; Vol. 16 (1), pp. 87-94. Date of Electronic Publication: 2019 Nov 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Oxidation-Reduction*
NADP/*chemistry
Nicotinamide Mononucleotide/*chemistry
Biocatalysis ; Carbon/chemistry ; Chromatography, Gas ; Cyclohexanones/chemistry ; Escherichia coli/metabolism ; Kinetics ; NAD/chemistry ; Nicotinamide Mononucleotide/genetics ; Protein Conformation ; Protein Engineering ; Pseudomonas putida/metabolism ; Ralstonia/metabolism ; Software
Czasopismo naukowe
Tytuł :
Assessment of visfatin concentrations in the serum of male psoriatic patients in relation to metabolic abnormalities.
Autorzy :
Chyl-Surdacka KM; Department of Dermatology, Venerology and Paediatric Dermatology, Medical University of Lublin, Poland.
Bartosińska J; Department of Dermatology, Venerology and Paediatric Dermatology, Medical University of Lublin, Poland.
Kowal M; Department of Dermatology, Venerology and Paediatric Dermatology, Medical University of Lublin, Poland.
Przepiórka-Kosińska J; Department of Dermatology, Venerology and Paediatric Dermatology, Medical University of Lublin, Poland.
Krasowska D; Department of Dermatology, Venerology and Paediatric Dermatology, Medical University of Lublin, Poland.
Chodorowska G; Department of Dermatology, Venerology and Paediatric Dermatology, Medical University of Lublin, Poland.
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Źródło :
Advances in clinical and experimental medicine : official organ Wroclaw Medical University [Adv Clin Exp Med] 2020 Jan; Vol. 29 (1), pp. 79-84.
Typ publikacji :
Journal Article
MeSH Terms :
Metabolic Syndrome*/metabolism
Nicotinamide Phosphoribosyltransferase*/blood
Psoriasis*/metabolism
Case-Control Studies ; Cholesterol, HDL ; Humans ; Male ; Obesity/metabolism
Czasopismo naukowe
Tytuł :
Novel Propargyl-Linked Bisubstrate Analogues as Tight-Binding Inhibitors for Nicotinamide N -Methyltransferase.
Autorzy :
Chen D
Li L
Diaz K
Iyamu ID
Yadav R
Noinaj N
Huang R
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2019 Dec 12; Vol. 62 (23), pp. 10783-10797. Date of Electronic Publication: 2019 Dec 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Nicotinamide N-Methyltransferase/*antagonists & inhibitors
Drug Design ; HCT116 Cells ; Humans ; Nicotinamide N-Methyltransferase/metabolism ; Permeability ; Protein Binding
Czasopismo naukowe
Tytuł :
Investigating RNA expression profiles altered by nicotinamide mononucleotide therapy in a chronic model of alcoholic liver disease.
Autorzy :
Assiri MA; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Ali HR; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Marentette JO; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Yun Y; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Liu J; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, 27710, USA.
Hirschey MD; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, 27710, USA.; Department of Medicine, Division of Endocrinology, Metabolism, and Nutrition, Duke University Medical Center, Durham, NC, 27710, USA.
Saba LM; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Harris PS; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Fritz KS; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA. .
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Źródło :
Human genomics [Hum Genomics] 2019 Dec 10; Vol. 13 (1), pp. 65. Date of Electronic Publication: 2019 Dec 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Profiling*
Liver Diseases, Alcoholic/*drug therapy
Nicotinamide Mononucleotide/*therapeutic use
RNA/*genetics
Alanine Transaminase/blood ; Animals ; Aspartate Aminotransferases/blood ; Chronic Disease ; Disease Models, Animal ; Ethanol ; Gene Expression Regulation/drug effects ; Liver Diseases, Alcoholic/blood ; Liver Diseases, Alcoholic/genetics ; Metabolome ; Metabolomics ; Mice, Inbred C57BL ; Nicotinamide Mononucleotide/pharmacology ; Protective Agents/metabolism ; RNA/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Multi-targeted Effect of Nicotinamide Mononucleotide on Brain Bioenergetic Metabolism.
Autorzy :
Klimova N; Department of Anesthesiology, Center for Shock, Trauma and Anesthesiology Research, School of Medicine, University of Maryland, 685 West Baltimore Street, MSTF 534, Baltimore, MD, 21201, USA.
Kristian T; Veterans Affairs Maryland Health Care System, 10 North Greene Street, Baltimore, MD, 21201, USA. .; Department of Anesthesiology, Center for Shock, Trauma and Anesthesiology Research, School of Medicine, University of Maryland, 685 West Baltimore Street, MSTF 534, Baltimore, MD, 21201, USA. .
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Źródło :
Neurochemical research [Neurochem Res] 2019 Oct; Vol. 44 (10), pp. 2280-2287. Date of Electronic Publication: 2019 Jan 19.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Brain/*drug effects
Hydrolases/*drug effects
Mitochondria/*drug effects
Nicotinamide Mononucleotide/*pharmacology
Animals ; Brain/metabolism ; Humans ; Hydrolases/metabolism ; Mitochondria/metabolism ; NAD/drug effects ; NAD/metabolism ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/metabolism ; Niacinamide/metabolism ; Niacinamide/pharmacology ; Nicotinamide Mononucleotide/metabolism
Czasopismo naukowe
Tytuł :
SS‐31 and NMN: Two paths to improve metabolism and function in aged hearts.
Autorzy :
Whitson, Jeremy A. (AUTHOR)
Bitto, Alessandro (AUTHOR)
Zhang, Huiliang (AUTHOR)
Sweetwyne, Mariya T. (AUTHOR)
Coig, Rene (AUTHOR)
Bhayana, Saakshi (AUTHOR)
Shankland, Eric G. (AUTHOR)
Wang, Lu (AUTHOR)
Bammler, Theo K. (AUTHOR)
Mills, Kathryn F. (AUTHOR)
Imai, Shin‐Ichiro (AUTHOR)
Conley, Kevin E. (AUTHOR)
Marcinek, David J. (AUTHOR)
Rabinovitch, Peter S. (AUTHOR)
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Źródło :
Aging Cell. Oct2020, Vol. 19 Issue 10, p1-14. 14p.
Czasopismo naukowe

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