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Tytuł :
Synthesis and evaluation of anticancer activities of 2- or 4-substituted 3-( N -benzyltriazolylmethyl)-13α-oestrone derivatives.
Autorzy :
Jójárt R; Department of Organic Chemistry, University of Szeged, Szeged, Hungary.
Tahaei SAS; Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary.
Trungel-Nagy P; Department of Organic Chemistry, University of Szeged, Szeged, Hungary.
Kele Z; Department of Medicinal Chemistry, University of Szeged, Szeged, Hungary.
Minorics R; Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary.
Paragi G; MTA-SZTE Biomimetic Systems Research Group, University of Szeged, Szeged, Hungary.
Zupkó I; Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary.
Mernyák E; Department of Organic Chemistry, University of Szeged, Szeged, Hungary.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 58-67.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Estrone/*pharmacology
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Estrone/analogs & derivatives ; Estrone/chemistry ; Humans ; Mice ; Models, Molecular ; Molecular Structure ; NIH 3T3 Cells ; Polymerization/drug effects ; Structure-Activity Relationship ; Tubulin/metabolism
Czasopismo naukowe
Tytuł :
Transition metal-catalysed A-ring C-H activations and C(sp ) couplings in the 13α-oestrone series and in vitro evaluation of antiproliferative properties.
Autorzy :
Traj P; Department of Organic Chemistry, University of Szeged, Szeged, Hungary.
Abdolkhaliq AH; Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary.
Németh A; Department of Organic Chemistry, University of Szeged, Szeged, Hungary.
Dajcs ST; Department of Organic Chemistry, University of Szeged, Szeged, Hungary.
Tömösi F; Department of Medicinal Chemistry, University of Szeged, Szeged, Hungary.
Lanisnik-Rizner T; Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Zupkó I; Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary.
Mernyák E; Department of Organic Chemistry, University of Szeged, Szeged, Hungary.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 895-902.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Estrone/*pharmacology
Transition Elements/*chemistry
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Catalysis ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Estrone/analogs & derivatives ; Estrone/chemistry ; Humans ; Mice ; Microwaves ; Molecular Structure ; NIH 3T3 Cells ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Bisepoxide-Jeffamine microgel synthesis and application toward heterogeneous surface morphology for differential neuronal/non-neuronal cell responses in vitro.
Autorzy :
Yu X; State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, Liaoning, 116023, China; School of Chemical Engineering, Dalian University of Technology, Dalian, Liaoning, 116023, China.
Cheng F; State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, Liaoning, 116023, China; School of Chemical Engineering, Dalian University of Technology, Dalian, Liaoning, 116023, China.
He W; State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, Liaoning, 116023, China; School of Chemical Engineering, Dalian University of Technology, Dalian, Liaoning, 116023, China. Electronic address: .
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Źródło :
Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2021 Nov; Vol. 207, pp. 112009. Date of Electronic Publication: 2021 Jul 26.
Typ publikacji :
Journal Article
MeSH Terms :
Microgels*
Animals ; Chick Embryo ; Mice ; NIH 3T3 Cells ; Neurons ; Surface Properties ; Temperature
Czasopismo naukowe
Tytuł :
Distinct antigen uptake receptors route to the same storage compartments for cross-presentation in dendritic cells.
Autorzy :
Ho NI; Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands.
Camps MG; Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands.
Garcia-Vallejo JJ; Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands.
Bos E; Department of Molecular Cell Biology, Section Electron Microscopy, Leiden University Medical Center, Leiden, The Netherlands.
Koster AJ; Department of Molecular Cell Biology, Section Electron Microscopy, Leiden University Medical Center, Leiden, The Netherlands.
Verdoes M; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
van Kooyk Y; Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands.
Ossendorp F; Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands.
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Źródło :
Immunology [Immunology] 2021 Nov; Vol. 164 (3), pp. 494-506. Date of Electronic Publication: 2021 Jun 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cross-Priming*
Antigens/*metabolism
Dendritic Cells/*immunology
Lectins, C-Type/*metabolism
Receptors, IgG/*metabolism
Animals ; Antigen Presentation ; Antigens/immunology ; Cathepsins/metabolism ; Dendritic Cells/metabolism ; Dendritic Cells/ultrastructure ; Endosomes/immunology ; Endosomes/metabolism ; Endosomes/ultrastructure ; Histocompatibility Antigens Class I/metabolism ; Histocompatibility Antigens Class II/metabolism ; Lysosomes/immunology ; Lysosomes/metabolism ; Lysosomes/ultrastructure ; Mice ; Microscopy, Electron, Transmission ; Models, Animal ; NIH 3T3 Cells ; Primary Cell Culture
Czasopismo naukowe
Tytuł :
Therapeutic Neuroprotection by an Engineered Neurotrophin that Selectively Activates Tropomyosin Receptor Kinase (Trk) Family Neurotrophin Receptors but Not the p75 Neurotrophin Receptor.
Autorzy :
Brahimi F; Lady Davis Institute-Jewish General Hospital (F.B., A.G., H.U.S.), Pharmacology and Therapeutics (H.U.S.), and Ophthalmology and Vision Science (H.U.S.), McGill University, Montreal, Quebec, Canada; Otonomy, Inc., San Diego, California (S.Si., S.Sz., A.C.F.); and School of Engineering Science, Simon Fraser University, British Columbia, Canada (M.V.S.).
Galan A; Lady Davis Institute-Jewish General Hospital (F.B., A.G., H.U.S.), Pharmacology and Therapeutics (H.U.S.), and Ophthalmology and Vision Science (H.U.S.), McGill University, Montreal, Quebec, Canada; Otonomy, Inc., San Diego, California (S.Si., S.Sz., A.C.F.); and School of Engineering Science, Simon Fraser University, British Columbia, Canada (M.V.S.).
Siegel S; Lady Davis Institute-Jewish General Hospital (F.B., A.G., H.U.S.), Pharmacology and Therapeutics (H.U.S.), and Ophthalmology and Vision Science (H.U.S.), McGill University, Montreal, Quebec, Canada; Otonomy, Inc., San Diego, California (S.Si., S.Sz., A.C.F.); and School of Engineering Science, Simon Fraser University, British Columbia, Canada (M.V.S.).
Szobota S; Lady Davis Institute-Jewish General Hospital (F.B., A.G., H.U.S.), Pharmacology and Therapeutics (H.U.S.), and Ophthalmology and Vision Science (H.U.S.), McGill University, Montreal, Quebec, Canada; Otonomy, Inc., San Diego, California (S.Si., S.Sz., A.C.F.); and School of Engineering Science, Simon Fraser University, British Columbia, Canada (M.V.S.).
Sarunic MV; Lady Davis Institute-Jewish General Hospital (F.B., A.G., H.U.S.), Pharmacology and Therapeutics (H.U.S.), and Ophthalmology and Vision Science (H.U.S.), McGill University, Montreal, Quebec, Canada; Otonomy, Inc., San Diego, California (S.Si., S.Sz., A.C.F.); and School of Engineering Science, Simon Fraser University, British Columbia, Canada (M.V.S.).
Foster AC; Lady Davis Institute-Jewish General Hospital (F.B., A.G., H.U.S.), Pharmacology and Therapeutics (H.U.S.), and Ophthalmology and Vision Science (H.U.S.), McGill University, Montreal, Quebec, Canada; Otonomy, Inc., San Diego, California (S.Si., S.Sz., A.C.F.); and School of Engineering Science, Simon Fraser University, British Columbia, Canada (M.V.S.).
Saragovi HU; Lady Davis Institute-Jewish General Hospital (F.B., A.G., H.U.S.), Pharmacology and Therapeutics (H.U.S.), and Ophthalmology and Vision Science (H.U.S.), McGill University, Montreal, Quebec, Canada; Otonomy, Inc., San Diego, California (S.Si., S.Sz., A.C.F.); and School of Engineering Science, Simon Fraser University, British Columbia, Canada (M.V.S.) .
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Źródło :
Molecular pharmacology [Mol Pharmacol] 2021 Nov; Vol. 100 (5), pp. 491-501. Date of Electronic Publication: 2021 Aug 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Nerve Growth Factors/*metabolism
Nerve Tissue Proteins/*metabolism
Neuroprotection/*physiology
Protein Engineering/*methods
Receptor, trkA/*metabolism
Receptors, Growth Factor/*metabolism
Animals ; Axotomy/adverse effects ; Diabetic Neuropathies/drug therapy ; Diabetic Neuropathies/genetics ; Diabetic Neuropathies/metabolism ; Dose-Response Relationship, Drug ; HEK293 Cells ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; NIH 3T3 Cells ; Nerve Growth Factors/administration & dosage ; Nerve Growth Factors/genetics ; Nerve Tissue Proteins/genetics ; Neuroprotection/drug effects ; Optic Nerve/drug effects ; Optic Nerve/metabolism ; Receptor, trkA/genetics ; Receptors, Growth Factor/genetics
Czasopismo naukowe
Tytuł :
Regenerative effect of platelet-rich plasma in the murine ischemic limbs.
Autorzy :
Stilhano RS; Center for Gene Therapy Investigation, Universidade Federal de São Paulo (UNIFESP), Brazil; Department of Physiological Sciences, Faculdade de Ciências Médicas da Santa Casa de São Paulo (FCMSCSP), Brazil.
Denapoli PMA; Center for Gene Therapy Investigation, Universidade Federal de São Paulo (UNIFESP), Brazil.
Gallo CC; Center for Gene Therapy Investigation, Universidade Federal de São Paulo (UNIFESP), Brazil.
Samoto VY; Center for Gene Therapy Investigation, Universidade Federal de São Paulo (UNIFESP), Brazil.
Ingham SJM; Department of Orthopedic Surgery, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil.
Abdalla RJ; Department of Orthopedic Surgery, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil.
Koh TJ; Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, United States of America.
Han SW; Center for Gene Therapy Investigation, Universidade Federal de São Paulo (UNIFESP), Brazil; Department of Biophysics, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Nov 01; Vol. 284, pp. 119934. Date of Electronic Publication: 2021 Sep 08.
Typ publikacji :
Journal Article
MeSH Terms :
Hindlimb/*physiopathology
Ischemia/*physiopathology
Platelet-Rich Plasma/*metabolism
Regeneration/*physiology
Animals ; Cell Survival ; Gene Expression Regulation ; Mice ; Mice, Inbred C57BL ; Muscle, Skeletal/pathology ; NIH 3T3 Cells
Czasopismo naukowe
Tytuł :
Heptamethine Cyanine Dye MHI-148-Mediated Drug Delivery System to Enhance the Anticancer Efficiency of Paclitaxel.
Autorzy :
Raveendran A; Department of Materials Science & Engineering, Chonnam National University, Gwangju, 61186, Republic of Korea.
Poilil Surendran S; Department of Biomedical Sciences, Chonnam National University Medical School, Hwasun, 58128, Republic of Korea.
Ser J; Department of Materials Science & Engineering, Chonnam National University, Gwangju, 61186, Republic of Korea.
Alam K; Department of Materials Science & Engineering, Chonnam National University, Gwangju, 61186, Republic of Korea.
Cho H; Department of Materials Science & Engineering, Chonnam National University, Gwangju, 61186, Republic of Korea.
Jeong YY; Department of Radiology, Chonnam National University Hwasun Hospital, Hwasun, 58128, Republic of Korea.
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Źródło :
International journal of nanomedicine [Int J Nanomedicine] 2021 Oct 21; Vol. 16, pp. 7169-7180. Date of Electronic Publication: 2021 Oct 21 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Nanoparticles*
Paclitaxel*
Animals ; Carbocyanines ; Cell Line, Tumor ; Drug Delivery Systems ; Indoles ; Mice ; Mice, Nude ; NIH 3T3 Cells ; Tissue Distribution
Czasopismo naukowe
Tytuł :
A cyclic lipopeptide surfactin is a species-selective Hsp90 inhibitor that suppresses cyanobacterial growth.
Autorzy :
Nakamoto H; Department of Biochemistry and Molecular Biology, Graduate School of Science and Engineering, Saitama University, Saitama 338-8570, Japan.
Yokoyama Y; Department of Biochemistry and Molecular Biology, Graduate School of Science and Engineering, Saitama University, Saitama 338-8570, Japan.
Suzuki T; Department of Biochemistry and Molecular Biology, Graduate School of Science and Engineering, Saitama University, Saitama 338-8570, Japan.
Miyamoto Y; Department of Biochemistry and Molecular Biology, Graduate School of Science and Engineering, Saitama University, Saitama 338-8570, Japan.
Fujishiro T; Department of Biochemistry and Molecular Biology, Graduate School of Science and Engineering, Saitama University, Saitama 338-8570, Japan.
Morikawa M; Division of Biosphere Science, Graduate School of Environmental Science, Hokkaido University, Sapporo 060-0810, Japan.
Miyata Y; Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan.
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Źródło :
Journal of biochemistry [J Biochem] 2021 Oct 11; Vol. 170 (2), pp. 255-264.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Bacterial Agents/*pharmacology
HSP90 Heat-Shock Proteins/*antagonists & inhibitors
Lipopeptides/*pharmacology
Peptides, Cyclic/*pharmacology
Synechococcus/*drug effects
Adenosine Triphosphatases/metabolism ; Adenosine Triphosphate/metabolism ; Animals ; Anti-Bacterial Agents/metabolism ; COS Cells ; Chlorocebus aethiops ; Colistin/pharmacology ; Dimerization ; Escherichia coli/drug effects ; HSP90 Heat-Shock Proteins/metabolism ; Humans ; Hydrolysis ; Lipopeptides/metabolism ; Mice ; Molecular Docking Simulation/methods ; NIH 3T3 Cells ; Peptides, Cyclic/metabolism ; Saccharomyces cerevisiae/drug effects
SCR Organism :
Synechococcus elongatus
Czasopismo naukowe
Tytuł :
Circa-SCOPE: high-throughput live single-cell imaging method for analysis of circadian clock resetting.
Autorzy :
Manella G; Department of Biomolecular Sciences, Weizmann Institute of Science, 7610001, Rehovot, Israel.
Aizik D; Department of Biomolecular Sciences, Weizmann Institute of Science, 7610001, Rehovot, Israel.
Aviram R; Department of Biomolecular Sciences, Weizmann Institute of Science, 7610001, Rehovot, Israel.
Golik M; Department of Biomolecular Sciences, Weizmann Institute of Science, 7610001, Rehovot, Israel.
Asher G; Department of Biomolecular Sciences, Weizmann Institute of Science, 7610001, Rehovot, Israel. .
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Źródło :
Nature communications [Nat Commun] 2021 Oct 08; Vol. 12 (1), pp. 5903. Date of Electronic Publication: 2021 Oct 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Circadian Clocks/*physiology
Single-Cell Analysis/*methods
Time-Lapse Imaging/*methods
Animals ; Circadian Rhythm/physiology ; High-Throughput Screening Assays ; Humans ; Mice ; NIH 3T3 Cells ; Steroids/blood
Czasopismo naukowe
Tytuł :
The viscoelasticity of adherent cells follows a single power-law with distinct local variations within a single cell and across cell lines.
Autorzy :
Sanchez JG; Instituto de Ciencia de Materiales de Madrid, CSIC, c/Sor Juana Inés de la Cruz 3, 28049 Madrid, Spain. .
Espinosa FM; Instituto de Ciencia de Materiales de Madrid, CSIC, c/Sor Juana Inés de la Cruz 3, 28049 Madrid, Spain. .
Miguez R; Instituto de Ciencia de Materiales de Madrid, CSIC, c/Sor Juana Inés de la Cruz 3, 28049 Madrid, Spain. .
Garcia R; Instituto de Ciencia de Materiales de Madrid, CSIC, c/Sor Juana Inés de la Cruz 3, 28049 Madrid, Spain. .
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Źródło :
Nanoscale [Nanoscale] 2021 Oct 08; Vol. 13 (38), pp. 16339-16348. Date of Electronic Publication: 2021 Oct 08.
Typ publikacji :
Journal Article
MeSH Terms :
Fibroblasts*
Animals ; Elasticity ; Humans ; Mice ; Microscopy, Atomic Force ; NIH 3T3 Cells ; Viscosity
Czasopismo naukowe
Tytuł :
Phosphorylation-dependent subcellular redistribution of small myosin light chain kinase.
Autorzy :
Khapchaev AY; National Medical Research Center for Cardiology, 3rd Cherepkovskaya St., 15a, Moscow 121552, Russian Federation. Electronic address: .
Watterson DM; Northwestern University, 320 East Superior St., Chicago, IL 60611, USA.
Shirinsky VP; National Medical Research Center for Cardiology, 3rd Cherepkovskaya St., 15a, Moscow 121552, Russian Federation.
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Źródło :
Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2021 Oct; Vol. 1868 (11), pp. 119104. Date of Electronic Publication: 2021 Jul 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Myosin-Light-Chain Kinase/*metabolism
Animals ; HEK293 Cells ; Humans ; Mice ; NIH 3T3 Cells ; Phosphorylation ; Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
Production of wheat germ oil containing multilayer hydrogel dressing.
Autorzy :
Türkoğlu GC; Department of Textile Engineering, Faculty of Engineering, Dokuz Eylül University, İzmir, Turkey; Graduate School of Natural and Applied Sciences, Dokuz Eylül University, İzmir, Turkey. Electronic address: .
Sarıışık M; Department of Textile Engineering, Faculty of Engineering, Dokuz Eylül University, İzmir, Turkey. Electronic address: .
Karavana SY; Department of Pharmaceutical Technology, Faculty of Pharmacy, Ege University, İzmir, Turkey. Electronic address: .
Aydın Köse F; Department of Biochemistry, Faculty of Pharmacy, İzmir Katip Çelebi University, İzmir, Turkey. Electronic address: .
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Źródło :
Carbohydrate polymers [Carbohydr Polym] 2021 Oct 01; Vol. 269, pp. 118287. Date of Electronic Publication: 2021 Jun 02.
Typ publikacji :
Journal Article
MeSH Terms :
Bandages*
Alginates/*pharmacology
Epoxy Resins/*pharmacology
Hydrogels/*pharmacology
Plant Oils/*pharmacology
Alginates/chemistry ; Alginates/toxicity ; Animals ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Epoxy Resins/chemistry ; Epoxy Resins/toxicity ; Hydrogels/chemistry ; Hydrogels/toxicity ; Mice ; NIH 3T3 Cells ; Permeability ; Plant Oils/chemistry ; Plant Oils/toxicity ; Porosity ; Textiles ; Water/chemistry
Czasopismo naukowe
Tytuł :
A new antibacterial nano-system based on hematoporphyrin-carboxymethyl chitosan conjugate for enhanced photostability and photodynamic activity.
Autorzy :
Zhou T; School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan 430070, PR China.
Yin Y; School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan 430070, PR China; Rizhao Wuhan University of Technology Biomedicine and New Materials Research Institute, PR China. Electronic address: .
Cai W; School of Chemistry and Chemical Engineering, Guangzhou University, Guangzhou 510006, PR China. Electronic address: .
Wang H; Zhuhai Guojia New Materials Co., Ltd., Economic and Technological Development District, Zhuhai 519040, PR China.
Fan L; School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan 430070, PR China; Rizhao Wuhan University of Technology Biomedicine and New Materials Research Institute, PR China.
He G; School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan 430070, PR China.
Zhang J; School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan 430070, PR China.
Jiang M; School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan 430070, PR China.
Liu J; School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan 430070, PR China.
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Źródło :
Carbohydrate polymers [Carbohydr Polym] 2021 Oct 01; Vol. 269, pp. 118242. Date of Electronic Publication: 2021 May 25.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Bacterial Agents/*pharmacology
Chitosan/*analogs & derivatives
Hematoporphyrins/*pharmacology
Nanoparticles/*chemistry
Photosensitizing Agents/*pharmacology
Animals ; Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/radiation effects ; Anti-Bacterial Agents/toxicity ; Chitosan/chemical synthesis ; Chitosan/pharmacology ; Chitosan/radiation effects ; Chitosan/toxicity ; Escherichia coli/drug effects ; Hematoporphyrins/chemical synthesis ; Hematoporphyrins/radiation effects ; Hematoporphyrins/toxicity ; Light ; Mice ; Microbial Sensitivity Tests ; NIH 3T3 Cells ; Nanoparticles/radiation effects ; Nanoparticles/toxicity ; Particle Size ; Photosensitizing Agents/chemical synthesis ; Photosensitizing Agents/radiation effects ; Photosensitizing Agents/toxicity ; Reactive Oxygen Species/metabolism ; Staphylococcus aureus ; Surface-Active Agents/chemical synthesis ; Surface-Active Agents/pharmacology ; Surface-Active Agents/radiation effects ; Surface-Active Agents/toxicity
Czasopismo naukowe
Tytuł :
Cleaved Delta like 1 intracellular domain regulates neural development via Notch signal-dependent and -independent pathways.
Autorzy :
Okubo Y; Division of Cellular and Molecular Toxicology, Center for Biological Safety & Research, National Institute of Health Sciences, 1-18-1, Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.
Ohtake F; Division of Cellular and Molecular Toxicology, Center for Biological Safety & Research, National Institute of Health Sciences, 1-18-1, Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.; Institute for Advanced Life Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.
Igarashi K; Division of Cellular and Molecular Toxicology, Center for Biological Safety & Research, National Institute of Health Sciences, 1-18-1, Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.; Life Science Tokyo Advanced Research center (L-StaR), Hoshi University School of Pharmacy and Pharmaceutical Science, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.
Yasuhiko Y; Division of Cellular and Molecular Toxicology, Center for Biological Safety & Research, National Institute of Health Sciences, 1-18-1, Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.
Hirabayashi Y; Division of Cellular and Molecular Toxicology, Center for Biological Safety & Research, National Institute of Health Sciences, 1-18-1, Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.
Saga Y; Division of Mammalian Development, National Institute of Genetics, Yata 1111, Mishima 411-8540, Japan.; Department of Biological Science, Graduate School of Science, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.
Kanno J; Division of Cellular and Molecular Toxicology, Center for Biological Safety & Research, National Institute of Health Sciences, 1-18-1, Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.
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Źródło :
Development (Cambridge, England) [Development] 2021 Oct 01; Vol. 148 (19). Date of Electronic Publication: 2021 Oct 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
MAP Kinase Signaling System*
Neurogenesis*
Calcium-Binding Proteins/*metabolism
Receptors, Notch/*metabolism
Animals ; Binding Sites ; Calcium-Binding Proteins/chemistry ; Calcium-Binding Proteins/genetics ; Cell Proliferation ; Cells, Cultured ; Ganglia, Spinal/cytology ; Ganglia, Spinal/metabolism ; HEK293 Cells ; Humans ; Mice ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/metabolism ; NIH 3T3 Cells ; Neurons/cytology ; Neurons/metabolism ; Neurons/physiology ; Protein Binding
Czasopismo naukowe
Tytuł :
CENP-B promotes the centromeric localization of ZFAT to control transcription of noncoding RNA.
Autorzy :
Ishikura S; Department of Cell Biology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan; Center for Advanced Molecular Medicine, Fukuoka University, Fukuoka, Japan.
Yoshida K; Department of Cell Biology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan; Center for Advanced Molecular Medicine, Fukuoka University, Fukuoka, Japan.
Hashimoto S; Department of Cell Biology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Nakabayashi K; Department of Maternal-Fetal Biology, National Research Institute for Child Health and Development, Tokyo, Japan.
Tsunoda T; Department of Cell Biology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan; Center for Advanced Molecular Medicine, Fukuoka University, Fukuoka, Japan.
Shirasawa S; Department of Cell Biology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan; Center for Advanced Molecular Medicine, Fukuoka University, Fukuoka, Japan. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2021 Oct; Vol. 297 (4), pp. 101213. Date of Electronic Publication: 2021 Sep 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
Centromere/*metabolism
Centromere Protein B/*metabolism
RNA, Untranslated/*biosynthesis
Transcription Factors/*metabolism
Animals ; Centromere/genetics ; Centromere Protein B/genetics ; HEK293 Cells ; HeLa Cells ; Humans ; Mice ; NIH 3T3 Cells ; RNA, Untranslated/genetics ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
Deconvolution of multiplexed transcriptional responses to wood smoke particles defines rapid aryl hydrocarbon receptor signaling dynamics.
Autorzy :
Gupta A; Department of Medicine, National Jewish Health, Denver, Colorado, USA; Department of Medicine, University of Colorado, Aurora, Colorado, USA.
Sasse SK; Department of Medicine, National Jewish Health, Denver, Colorado, USA.
Gruca MA; BioFrontiers Institute, University of Colorado, Boulder, Colorado, USA.
Sanford L; BioFrontiers Institute, University of Colorado, Boulder, Colorado, USA.
Dowell RD; BioFrontiers Institute, University of Colorado, Boulder, Colorado, USA; Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado, USA; Department of Computer Science, University of Colorado, Boulder, Colorado, USA.
Gerber AN; Department of Medicine, National Jewish Health, Denver, Colorado, USA; Department of Medicine, University of Colorado, Aurora, Colorado, USA; Department of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado, USA. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2021 Oct; Vol. 297 (4), pp. 101147. Date of Electronic Publication: 2021 Sep 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Signal Transduction*
Transcription, Genetic*
Wood*
Basic Helix-Loop-Helix Transcription Factors/*metabolism
Receptors, Aryl Hydrocarbon/*metabolism
Repressor Proteins/*metabolism
Smoke/*adverse effects
Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Cell Line, Transformed ; Chromatin Assembly and Disassembly ; Cytochrome P-450 CYP1A1/biosynthesis ; Cytochrome P-450 CYP1A1/genetics ; DNA (Cytosine-5-)-Methyltransferases/biosynthesis ; DNA (Cytosine-5-)-Methyltransferases/genetics ; Humans ; Mice ; NF-kappa B/genetics ; NF-kappa B/metabolism ; NIH 3T3 Cells ; Receptors, Aryl Hydrocarbon/genetics ; Repressor Proteins/genetics
Czasopismo naukowe
Tytuł :
Gene-teratogen interactions influence the penetrance of birth defects by altering Hedgehog signaling strength.
Autorzy :
Kong JH; Departments of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Young CB; Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15201, USA.
Pusapati GV; Departments of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Espinoza FH; Departments of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Patel CB; Departments of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Beckert F; Departments of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Ho S; Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15201, USA.
Patel BB; Departments of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Gabriel GC; Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15201, USA.
Aravind L; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.
Bazan JF; H Bioconsulting, Stillwater, MN 50082, USA.
Gunn TM; McLaughlin Research Institute, Great Falls, MT 59405, USA.
Lo CW; Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15201, USA.
Rohatgi R; Departments of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Pokaż więcej
Źródło :
Development (Cambridge, England) [Development] 2021 Oct 01; Vol. 148 (19). Date of Electronic Publication: 2021 Oct 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gene-Environment Interaction*
Penetrance*
Abnormalities, Drug-Induced/*genetics
Hedgehog Proteins/*metabolism
Animals ; Cells, Cultured ; HEK293 Cells ; Humans ; Mice ; Mice, Inbred C57BL ; NIH 3T3 Cells ; Signal Transduction ; Smoothened Receptor/genetics ; Smoothened Receptor/metabolism
Czasopismo naukowe
Tytuł :
Xuanfei Baidu Decoction protects against macrophages induced inflammation and pulmonary fibrosis via inhibiting IL-6/STAT3 signaling pathway.
Autorzy :
Wang Y; State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Sang X; State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Shao R; State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Qin H; State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Chen X; State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Tianjin Key Laboratory of Phytochemistry and Pharmaceutical Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Xue Z; State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Li L; State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Tianjin University of Traditional Chinese Medicine, Ministry of Education, Tianjin, 301617, China.
Wang Y; School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Zhu Y; State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Chang Y; State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Tianjin Key Laboratory of Phytochemistry and Pharmaceutical Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Gao X; State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Tianjin University of Traditional Chinese Medicine, Ministry of Education, Tianjin, 301617, China.
Zhang B; State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Tianjin University of Traditional Chinese Medicine, Ministry of Education, Tianjin, 301617, China.
Zhang H; State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Tianjin University of Traditional Chinese Medicine, Ministry of Education, Tianjin, 301617, China. Electronic address: .
Yang J; State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2022 Jan 30; Vol. 283, pp. 114701. Date of Electronic Publication: 2021 Oct 01.
Typ publikacji :
Journal Article
MeSH Terms :
Drugs, Chinese Herbal*/pharmacology
Drugs, Chinese Herbal*/therapeutic use
SARS-CoV-2*
COVID-19/*drug therapy
Inflammation/*drug therapy
Macrophages/*drug effects
Signal Transduction/*drug effects
Animals ; Cell Survival/drug effects ; Fibroblasts/drug effects ; Gene Expression Regulation/drug effects ; Gene Regulatory Networks ; Humans ; Interleukin-6/antagonists & inhibitors ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; NIH 3T3 Cells ; Phytotherapy ; Pulmonary Fibrosis/pathology ; Pulmonary Fibrosis/prevention & control ; RAW 264.7 Cells ; STAT3 Transcription Factor/antagonists & inhibitors ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/metabolism
Czasopismo naukowe
Tytuł :
Unraveling the functional role of DNA demethylation at specific promoters by targeted steric blockage of DNA methyltransferase with CRISPR/dCas9.
Autorzy :
Sapozhnikov DM; Department of Pharmacology and Therapeutics, Faculty of Medicine, McGill University, Montreal, QC, Canada.
Szyf M; Department of Pharmacology and Therapeutics, Faculty of Medicine, McGill University, Montreal, QC, Canada. .
Pokaż więcej
Źródło :
Nature communications [Nat Commun] 2021 Sep 29; Vol. 12 (1), pp. 5711. Date of Electronic Publication: 2021 Sep 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Demethylation*
Epigenesis, Genetic*
DNA Modification Methylases/*metabolism
Mixed Function Oxygenases/*metabolism
Proto-Oncogene Proteins/*metabolism
Animals ; CRISPR-Cas Systems/genetics ; CpG Islands/genetics ; DNA Methylation ; DNA Modification Methylases/genetics ; Fragile X Mental Retardation Protein/genetics ; Gene Editing/methods ; HEK293 Cells ; Humans ; Mice ; Mixed Function Oxygenases/genetics ; NIH 3T3 Cells ; Promoter Regions, Genetic/genetics ; Proto-Oncogene Proteins/genetics ; RNA, Guide/metabolism ; Serpins/genetics
Czasopismo naukowe
Tytuł :
Poly (caprolactone)/sodium-alginate-functionalized halloysite clay nanotube nanocomposites: Potent biocompatible materials for wound healing applications.
Autorzy :
Kouser S; Department of Chemistry, Mangalore University, Mangalagangothri-574199, Karnataka, India.
Prabhu A; Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalor-575018, Karnataka, India.
Sheik S; Department of Chemistry, P.A. College of Engineering, Mangalore-574153, Karnataka, India.
Prashantha K; ACU-Centre for Research and Innovation, Faculty of Natural Sciences, Adichunchanagiri University, Mandya District-571448, Karnataka, India.
Nagaraja GK; Department of Chemistry, Mangalore University, Mangalagangothri-574199, Karnataka, India. Electronic address: .
D'souza JN; Department of Chemistry, Mangalore University, Mangalagangothri-574199, Karnataka, India.
Navada KM; Department of Chemistry, Mangalore University, Mangalagangothri-574199, Karnataka, India.
Manasa DJ; Department of Botany, Davanagere University, Davanagere-577007, Karnataka, India.
Pokaż więcej
Źródło :
International journal of pharmaceutics [Int J Pharm] 2021 Sep 25; Vol. 607, pp. 121048. Date of Electronic Publication: 2021 Aug 25.
Typ publikacji :
Journal Article
MeSH Terms :
Nanocomposites*
Nanotubes*
Alginates ; Animals ; Biocompatible Materials ; Caproates ; Clay ; Lactones ; Mice ; NIH 3T3 Cells ; Sodium ; Wound Healing
Czasopismo naukowe

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