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Wyszukujesz frazę ""NITRIC oxide"" wg kryterium: Temat


Tytuł :
Nitric Oxide Synthase Inhibitors into the Clinic at Last.
Autorzy :
Dao VT; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.
Elbatreek MH; Department of Pharmacology and Personalised Medicine, MeHNS, FHML, Maastricht, The Netherlands.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
Fuchß T; Takeda GmbH (former Nycomed/Altana Pharma), Konstanz, Germany.
Grädler U; Takeda GmbH (former Nycomed/Altana Pharma), Konstanz, Germany.
Schmidt HHHW; Department of Pharmacology and Personalised Medicine, MeHNS, FHML, Maastricht, The Netherlands.
Shah AM; King's College London British Heart Foundation Centre, School of Cardiovascular Medicine and Sciences, London, UK.
Wallace A; Health and Life Sciences, Coventry University, Coventry, UK.
Knowles R; Knowles Consulting Ltd., The Stevenage Bioscience Catalyst, Stevenage, UK. .
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Źródło :
Handbook of experimental pharmacology [Handb Exp Pharmacol] 2021; Vol. 264, pp. 169-204.
Typ publikacji :
Journal Article
MeSH Terms :
Nitric Oxide Synthase*/metabolism
Nitric Oxide Synthase Type III*
Cyclic GMP ; Humans ; Nitric Oxide ; Reactive Oxygen Species ; Signal Transduction
Czasopismo naukowe
Tytuł :
Tetrahydrobiopterin and Nitric Oxide Synthase Recouplers.
Autorzy :
Channon KM; BHF Field Marshal Earl Alexander Professor of Cardiovascular Medicine, University of Oxford and Oxford University Hospitals, Oxford, UK. .
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Źródło :
Handbook of experimental pharmacology [Handb Exp Pharmacol] 2021; Vol. 264, pp. 339-352.
Typ publikacji :
Journal Article
MeSH Terms :
Biopterin*/analogs & derivatives
Nitric Oxide Synthase*
Humans ; Nitric Oxide ; Nitric Oxide Synthase Type III ; Reactive Oxygen Species
Czasopismo naukowe
Tytuł :
Nitric oxide effects on Rhodnius prolixus's immune responses, gut microbiota and Trypanosoma cruzi development.
Autorzy :
Batista KKDS; Laboratório de Bioquímica e Fisiologia de Insetos, Instituto Oswaldo Cruz (IOC/Fiocruz), Rio de Janeiro, RJ, Brazil.
Vieira CS; Laboratório de Bioquímica e Fisiologia de Insetos, Instituto Oswaldo Cruz (IOC/Fiocruz), Rio de Janeiro, RJ, Brazil.
Florentino EB; Laboratório de Bioquímica e Fisiologia de Insetos, Instituto Oswaldo Cruz (IOC/Fiocruz), Rio de Janeiro, RJ, Brazil.
Caruso KFB; Laboratório de Bioquímica e Fisiologia de Insetos, Instituto Oswaldo Cruz (IOC/Fiocruz), Rio de Janeiro, RJ, Brazil.
Teixeira PTP; Laboratório de Bioquímica e Fisiologia de Insetos, Instituto Oswaldo Cruz (IOC/Fiocruz), Rio de Janeiro, RJ, Brazil.
Moraes CDS; Laboratório de Bioquímica e Fisiologia de Insetos, Instituto Oswaldo Cruz (IOC/Fiocruz), Rio de Janeiro, RJ, Brazil.
Genta FA; Laboratório de Bioquímica e Fisiologia de Insetos, Instituto Oswaldo Cruz (IOC/Fiocruz), Rio de Janeiro, RJ, Brazil; Departamento de Entomologia Molecular, Instituto Nacional de Entomologia Molecular (INCT-EM), Rio de Janeiro, RJ, Brazil.
de Azambuja P; Departamento de Entomologia Molecular, Instituto Nacional de Entomologia Molecular (INCT-EM), Rio de Janeiro, RJ, Brazil; Programa de Pós-Graduação em Ciências e Biotecnologia, Universidade Federal Fluminense, Niteroi, RJ, Brazil.
de Castro DP; Laboratório de Bioquímica e Fisiologia de Insetos, Instituto Oswaldo Cruz (IOC/Fiocruz), Rio de Janeiro, RJ, Brazil; Departamento de Entomologia Molecular, Instituto Nacional de Entomologia Molecular (INCT-EM), Rio de Janeiro, RJ, Brazil. Electronic address: .
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Źródło :
Journal of insect physiology [J Insect Physiol] 2020 Oct; Vol. 126, pp. 104100. Date of Electronic Publication: 2020 Aug 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Nitric Oxide*/metabolism
Nitric Oxide*/pharmacology
Rhodnius*/immunology
Rhodnius*/microbiology
Rhodnius*/parasitology
Gastrointestinal Microbiome/*drug effects
Immune System/*drug effects
Trypanosoma cruzi/*drug effects
Animals ; Arginine/antagonists & inhibitors ; Arginine/pharmacology ; Catalase/drug effects ; Catalase/metabolism ; Gastrointestinal Tract/drug effects ; Gastrointestinal Tract/microbiology ; Gene Expression/drug effects ; Genes, Insect ; Hemolymph/drug effects ; Hemolymph/immunology ; Hemolymph/metabolism ; Immunity, Humoral/drug effects ; Insect Vectors/immunology ; Insect Vectors/microbiology ; Insect Vectors/parasitology ; Monophenol Monooxygenase/drug effects ; Monophenol Monooxygenase/metabolism ; NG-Nitroarginine Methyl Ester/pharmacology ; Nitric Oxide Synthase/genetics ; Nitric Oxide Synthase/metabolism
Czasopismo naukowe
Tytuł :
High salt intake induces collecting duct HDAC1-dependent NO signaling.
Autorzy :
Sedaka R; Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Hyndman KA; Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Mironova E; Department of Cellular and Integrative Physiology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas.
Stockand JD; Department of Cellular and Integrative Physiology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas.
Pollock JS; Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
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Źródło :
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2021 Mar 01; Vol. 320 (3), pp. F297-F307. Date of Electronic Publication: 2020 Dec 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Natriuresis*
Renal Elimination*
Histone Deacetylase 1/*metabolism
Kidney Tubules, Collecting/*enzymology
Nitric Oxide/*metabolism
Sodium Chloride, Dietary/*administration & dosage
Animals ; Endothelin-1/metabolism ; Male ; Mice, Inbred C57BL ; Nitric Oxide Synthase Type I/metabolism ; Receptor, Endothelin B/metabolism ; Signal Transduction ; Sodium Chloride, Dietary/urine
Czasopismo naukowe
Tytuł :
Effects of nitrite and far-red light on coagulation.
Autorzy :
Wajih N; Department of Physics, Wake Forest University, Winston-Salem, NC, 27109, United States; Translational Science Center, Wake Forest University, Winston-Salem, NC, 27109, United States. Electronic address: .
Alipour E; Department of Physics, Wake Forest University, Winston-Salem, NC, 27109, United States. Electronic address: .
Rigal F; Department of Physics, Wake Forest University, Winston-Salem, NC, 27109, United States. Electronic address: .
Zhu J; Department of Physics, Wake Forest University, Winston-Salem, NC, 27109, United States. Electronic address: .
Perlegas A; Department of Physics, Wake Forest University, Winston-Salem, NC, 27109, United States.
Caudell DL; Department of Pathology,-Section on Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, United States. Electronic address: .
Kim-Shapiro D; Department of Physics, Wake Forest University, Winston-Salem, NC, 27109, United States; Translational Science Center, Wake Forest University, Winston-Salem, NC, 27109, United States. Electronic address: .
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Źródło :
Nitric oxide : biology and chemistry [Nitric Oxide] 2021 Feb 01; Vol. 107, pp. 11-18. Date of Electronic Publication: 2020 Nov 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Blood Coagulation/*drug effects
Blood Coagulation/*radiation effects
Nitric Oxide Donors/*pharmacology
Nitrites/*pharmacology
Blood Platelets/drug effects ; Blood Platelets/radiation effects ; COVID-19/drug therapy ; COVID-19/radiotherapy ; Humans ; Light ; Nitric Oxide/metabolism ; Platelet Activation/drug effects ; Platelet Activation/radiation effects ; Platelet Adhesiveness/drug effects ; Platelet Adhesiveness/radiation effects ; Platelet Aggregation/drug effects ; Platelet Aggregation/radiation effects ; SARS-CoV-2/drug effects
Czasopismo naukowe
Tytuł :
Modulation of Nitric Oxide Bioavailability Attenuates Ischemia-Reperfusion Injury in Type II Diabetes.
Autorzy :
Gazyakan E; Department of Hand, Plastic and Reconstructive Surgery, Burn Center, BG Trauma Center Ludwigshafen, Hand and Plastic Surgery, University of Heidelberg, Ludwig-Guttmann-Strasse 13, 67071 Ludwigshafen, Germany.
Hirche C; Department of Hand, Plastic and Reconstructive Surgery, Burn Center, BG Trauma Center Ludwigshafen, Hand and Plastic Surgery, University of Heidelberg, Ludwig-Guttmann-Strasse 13, 67071 Ludwigshafen, Germany.
Reichenberger MA; ETHIANUM-Clinic for Plastic and Reconstructive Surgery, Aesthetic and Preventive Medicine at Heidelberg University Hospital, Voßstraße 6, 69115 Heidelberg, Germany.
Urbach O; Department of Hand, Plastic and Reconstructive Surgery, Burn Center, BG Trauma Center Ludwigshafen, Hand and Plastic Surgery, University of Heidelberg, Ludwig-Guttmann-Strasse 13, 67071 Ludwigshafen, Germany.
Germann G; ETHIANUM-Clinic for Plastic and Reconstructive Surgery, Aesthetic and Preventive Medicine at Heidelberg University Hospital, Voßstraße 6, 69115 Heidelberg, Germany.
Engel H; Department of Hand, Plastic and Reconstructive Surgery, Burn Center, BG Trauma Center Ludwigshafen, Hand and Plastic Surgery, University of Heidelberg, Ludwig-Guttmann-Strasse 13, 67071 Ludwigshafen, Germany; ETHIANUM-Clinic for Plastic and Reconstructive Surgery, Aesthetic and Preventive Medicine at Heidelberg University Hospital, Voßstraße 6, 69115 Heidelberg, Germany. Electronic address: .
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Źródło :
Journal of plastic, reconstructive & aesthetic surgery : JPRAS [J Plast Reconstr Aesthet Surg] 2021 Jan; Vol. 74 (1), pp. 183-191. Date of Electronic Publication: 2020 Aug 20.
Typ publikacji :
Journal Article
MeSH Terms :
Arginine/*pharmacology
Diabetes Mellitus, Type 2/*metabolism
Nitric Oxide/*biosynthesis
Nitric Oxide Synthase/*pharmacology
Reperfusion Injury/*metabolism
Surgical Flaps/*physiology
Animals ; Diabetes Mellitus, Experimental/metabolism ; Disease Models, Animal ; Male ; Nitric Oxide Synthase Type I/pharmacology ; Nitric Oxide Synthase Type II/pharmacology ; Nitric Oxide Synthase Type III/pharmacology ; Rats ; Rats, Wistar ; Skin/metabolism
Czasopismo naukowe
Tytuł :
Modulation of peroxynitrite produced via mitochondrial nitric oxide synthesis during Ca and succinate-induced oxidative stress in cardiac isolated mitochondria.
Autorzy :
Gerdes HJ; Anesthesiology Research Division, Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Yang M; Anesthesiology Research Division, Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Heisner JS; Anesthesiology Research Division, Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Camara AKS; Anesthesiology Research Division, Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA; Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, USA; Cancer Center, Medical College of Wisconsin, Milwaukee, WI, USA.
Stowe DF; Anesthesiology Research Division, Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA; Cancer Center, Medical College of Wisconsin, Milwaukee, WI, USA; Department of Biomedical Engineering, Medical College of Wisconsin and Marquette University, Milwaukee, WI, USA; Research Service, Zablocki Veterans Affairs Medical Center, Milwaukee, WI, USA. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Bioenergetics [Biochim Biophys Acta Bioenerg] 2020 Dec 01; Vol. 1861 (12), pp. 148290. Date of Electronic Publication: 2020 Aug 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Calcium/*pharmacology
Mitochondria, Heart/*metabolism
Nitric Oxide/*biosynthesis
Oxidative Stress/*drug effects
Peroxynitrous Acid/*metabolism
Succinic Acid/*pharmacology
Animals ; Electron Transport/drug effects ; Free Radical Scavengers/metabolism ; Guinea Pigs ; Hydrogen Peroxide/metabolism ; Isoenzymes/metabolism ; Isoenzymes/ultrastructure ; Membrane Potential, Mitochondrial/drug effects ; Mitochondria, Heart/drug effects ; Mitochondria, Heart/ultrastructure ; Nitric Oxide Synthase/antagonists & inhibitors ; Nitric Oxide Synthase/metabolism ; Nitric Oxide Synthase/ultrastructure ; Spectrometry, Fluorescence ; Stress, Physiological/drug effects ; Superoxide Dismutase/metabolism ; Time Factors
Czasopismo naukowe
Tytuł :
Synergistic effects of nitric oxide and silicon on promoting plant growth, oxidative stress tolerance and reduction of arsenic uptake in Brassica juncea.
Autorzy :
Ahmad A; Guangdong Key Laboratory for New Technology Research of Vegetables/ Vegetable Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou, 510640, China.
Khan WU; College of Earth and Environmental Sciences, University of the Punjab, Lahore, Pakistan.
Ali Shah A; Department of Botany, University of Narowal, Pakistan.
Yasin NA; SSG, RO-II, University of the Punjab, Lahore, Pakistan. Electronic address: .
Naz S; Department of Biotechnology, Lahore College for Women University, Pakistan.
Ali A; Department of Botany, University of Sargodha, Pakistan.
Tahir A; Department of Biotechnology, Lahore College for Women University, Pakistan.
Iram Batool A; Department of Zoology, University of Sargodha, Pakistan.
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Źródło :
Chemosphere [Chemosphere] 2021 Jan; Vol. 262, pp. 128384. Date of Electronic Publication: 2020 Sep 21.
Typ publikacji :
Journal Article
MeSH Terms :
Arsenic/*metabolism
Mustard Plant/*physiology
Nitric Oxide/*chemistry
Silicon/*chemistry
Soil Pollutants/*metabolism
Antioxidants/metabolism ; Arsenic/toxicity ; Ascorbate Peroxidases/metabolism ; Glutathione/metabolism ; Glutathione Reductase/metabolism ; Hydrogen Peroxide/metabolism ; Malondialdehyde/metabolism ; Mustard Plant/metabolism ; Nitric Oxide Donors/metabolism ; Nitric Oxide Donors/pharmacology ; Nitroprusside/pharmacology ; Oxidative Stress/drug effects ; Seedlings/drug effects ; Soil Pollutants/toxicity ; Superoxide Dismutase/metabolism
Czasopismo naukowe
Tytuł :
Modulating the Bioactivity of Nitric Oxide as a Therapeutic Strategy in Cardiac Surgery.
Autorzy :
Pisarenko O; National Medical Research Center for Cardiology, Institute of Experimental Cardiology, Moscow, Russian Federation. Electronic address: .
Studneva I; National Medical Research Center for Cardiology, Institute of Experimental Cardiology, Moscow, Russian Federation.
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Źródło :
The Journal of surgical research [J Surg Res] 2021 Jan; Vol. 257, pp. 178-188. Date of Electronic Publication: 2020 Aug 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Cardiotonic Agents/*pharmacology
Heart Arrest, Induced/*adverse effects
Myocardial Reperfusion Injury/*prevention & control
Nitric Oxide/*metabolism
Animals ; Cardiotonic Agents/therapeutic use ; Disease Models, Animal ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Endothelium, Vascular/cytology ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/pathology ; Gap Junctions/drug effects ; Heart/drug effects ; Humans ; Ion Channels/metabolism ; MicroRNAs/therapeutic use ; Myocardial Reperfusion Injury/etiology ; Myocardial Reperfusion Injury/pathology ; Myocardium/pathology ; Nitric Oxide/agonists ; Nitric Oxide Synthase Type III/genetics ; Nitric Oxide Synthase Type III/metabolism ; Stem Cell Transplantation/methods
Czasopismo naukowe
Tytuł :
Role of nitric oxide in the response to photooxidative stress in prostate cancer cells.
Autorzy :
D'Este F; Department of Medicine, University of Udine, P.le Kolbe 4, 33100 Udine, Italy.
Della Pietra E; Department of Medicine, University of Udine, P.le Kolbe 4, 33100 Udine, Italy.
Badillo Pazmay GV; Department of Medicine, University of Udine, P.le Kolbe 4, 33100 Udine, Italy.
Xodo LE; Department of Medicine, University of Udine, P.le Kolbe 4, 33100 Udine, Italy. Electronic address: .
Rapozzi V; Department of Medicine, University of Udine, P.le Kolbe 4, 33100 Udine, Italy. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Dec; Vol. 182, pp. 114205. Date of Electronic Publication: 2020 Aug 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Nitric Oxide/*physiology
Oxidative Stress/*physiology
Prostatic Neoplasms/*metabolism
Radiation-Sensitizing Agents/*toxicity
Reactive Oxygen Species/*metabolism
Cell Line, Tumor ; Chlorophyll/analogs & derivatives ; Chlorophyll/toxicity ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/pharmacology ; Humans ; Male ; NG-Nitroarginine Methyl Ester/pharmacology ; Nitric Oxide/antagonists & inhibitors ; Nitric Oxide/radiation effects ; Nitric Oxide Synthase Type II/metabolism ; Nitric Oxide Synthase Type II/radiation effects ; Oxidative Stress/drug effects ; Oxidative Stress/radiation effects ; Prostatic Neoplasms/pathology ; Reactive Oxygen Species/radiation effects
Czasopismo naukowe
Tytuł :
NOX5-induced uncoupling of endothelial NO synthase is a causal mechanism and theragnostic target of an age-related hypertension endotype.
Autorzy :
Elbatreek MH; Department of Pharmacology and Personalised Medicine, School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands.; Department of Pharmacology and Toxicology, School of Pharmacy, Zagazig University, Zagazig, Egypt.
Sadegh S; Chair of Experimental Bioinformatics, TUM School of Life Sciences Weihenstephan, Technical University of Munich, Munich, Germany.
Anastasi E; School of Computing, Newcastle University, Newcastle, United Kingdom.
Guney E; Department of Pharmacology and Personalised Medicine, School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands.; Research Programme on Biomedical Informatics, The Hospital del Mar Medical Research Institute and Pompeu Fabra University, Barcelona, Spain.
Nogales C; Department of Pharmacology and Personalised Medicine, School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands.
Kacprowski T; Chair of Experimental Bioinformatics, TUM School of Life Sciences Weihenstephan, Technical University of Munich, Munich, Germany.; Division of Data Science in Biomedicine, Peter L. Reichertz Institute for Medical Informatics of TU Braunschweig and Hannover Medical School, Brunswick, Germany.
Hassan AA; Department of Pharmacology and Personalised Medicine, School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands.
Teubner A; Central Animal Facility, CPV, Maastricht University, Maastricht, the Netherlands.
Huang PH; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.; Department of Critical Care Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Hsu CY; Division of Cardiology and Cardiovascular Research Center, Taipei Medical University Hospital, Taipei, Taiwan.; Taipei Heart Institute, Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Schiffers PMH; Department of Pharmacology and Toxicology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands.
Janssen GM; Department of Pharmacology and Toxicology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands.
Kleikers PWM; Department of Pharmacology and Personalised Medicine, School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands.
Wipat A; School of Computing, Newcastle University, Newcastle, United Kingdom.
Baumbach J; Chair of Experimental Bioinformatics, TUM School of Life Sciences Weihenstephan, Technical University of Munich, Munich, Germany.; Department of Mathematics and Computer Science, University of Southern Denmark, Odense, Denmark.
De Mey JGR; Department of Pharmacology and Personalised Medicine, School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands.
Schmidt HHHW; Department of Pharmacology and Personalised Medicine, School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands.
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Źródło :
PLoS biology [PLoS Biol] 2020 Nov 10; Vol. 18 (11), pp. e3000885. Date of Electronic Publication: 2020 Nov 10 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hypertension/*physiopathology
NADPH Oxidase 5/*genetics
Nitric Oxide/*metabolism
Adult ; Age Factors ; Aged ; Animals ; Endothelial Cells ; Endothelium, Vascular ; Female ; Gene Knock-In Techniques/methods ; Humans ; Hypertension/genetics ; Hypertension/metabolism ; Male ; Membrane Proteins/genetics ; Mice ; Middle Aged ; NADPH Oxidase 5/metabolism ; NADPH Oxidases/genetics ; NADPH Oxidases/metabolism ; Nitric Oxide/genetics ; Nitric Oxide Synthase/genetics ; Nitric Oxide Synthase/metabolism ; Nitric Oxide Synthase Type III/genetics ; Nitric Oxide Synthase Type III/metabolism ; Reactive Oxygen Species
Czasopismo naukowe
Tytuł :
A new mechanism for the sex differences in angiotensin II-induced hypertension: the role of macula densa NOS1β-mediated tubuloglomerular feedback.
Autorzy :
Zhang J; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida.
Qu L; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida.
Wei J; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida.
Jiang S; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida.
Xu L; College of Public Health, University of South Florida, Tampa, Florida.
Wang L; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida.
Cheng F; Department of Pharmaceutical Science, College of Pharmacy, University of South Florida, Tampa, Florida.
Jiang K; Department of Anatomic Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Buggs J; Advanced Organ Disease and Transplantation Institute, Tampa General Hospital, Tampa, Florida.
Liu R; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida.
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Źródło :
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2020 Nov 01; Vol. 319 (5), pp. F908-F919. Date of Electronic Publication: 2020 Oct 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Sex Characteristics*
Hypertension/*metabolism
Kidney Tubules/*drug effects
Nitric Oxide Synthase/*metabolism
Angiotensin II/pharmacology ; Animals ; Feedback ; Female ; Glomerular Filtration Rate/drug effects ; Hypertension/chemically induced ; Kidney Cortex/metabolism ; Kidney Glomerulus/drug effects ; Kidney Glomerulus/metabolism ; Kidney Tubules/metabolism ; Male ; Mice, Knockout ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type I/metabolism
Czasopismo naukowe
Tytuł :
Nitric Oxide and S-Nitrosylation in Cardiac Regulation: G Protein-Coupled Receptor Kinase-2 and β-Arrestins as Targets.
Autorzy :
Kayki-Mutlu G; Center for Translational Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA.; Faculty of Pharmacy, Department of Pharmacology, Ankara University, Tandogan, 06560 Ankara, Turkey.
Koch WJ; Center for Translational Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jan 07; Vol. 22 (2). Date of Electronic Publication: 2021 Jan 07.
Typ publikacji :
Journal Article; Review
MeSH Terms :
G-Protein-Coupled Receptor Kinase 2/*genetics
Nitric Oxide/*genetics
Receptors, Adrenergic, beta/*genetics
beta-Arrestins/*genetics
Cyclic GMP/genetics ; Cyclic GMP-Dependent Protein Kinases/genetics ; Humans ; Nitric Oxide Synthase/genetics ; S-Nitrosothiols/metabolism ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Bitter taste receptors stimulate phagocytosis in human macrophages through calcium, nitric oxide, and cyclic-GMP signaling.
Autorzy :
Gopallawa I; Department of Otorhinolaryngology, Head and Neck Surgery, Hospital of the University of Pennsylvania, University of Pennsylvania Perelman School of Medicine, Ravdin, 5th Floor, Suite A , 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Freund JR; Department of Otorhinolaryngology, Head and Neck Surgery, Hospital of the University of Pennsylvania, University of Pennsylvania Perelman School of Medicine, Ravdin, 5th Floor, Suite A , 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Lee RJ; Department of Otorhinolaryngology, Head and Neck Surgery, Hospital of the University of Pennsylvania, University of Pennsylvania Perelman School of Medicine, Ravdin, 5th Floor, Suite A , 3400 Spruce Street, Philadelphia, PA, 19104, USA. .; Department of Physiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Jan; Vol. 78 (1), pp. 271-286. Date of Electronic Publication: 2020 Mar 14.
Typ publikacji :
Journal Article
MeSH Terms :
Phagocytosis*/drug effects
Signal Transduction*/drug effects
Calcium/*metabolism
Cyclic GMP/*metabolism
Nitric Oxide/*metabolism
Receptors, G-Protein-Coupled/*metabolism
Cell Communication ; Cells, Cultured ; Coculture Techniques ; Epithelial Cells/cytology ; Epithelial Cells/metabolism ; Humans ; Macrophages/cytology ; Macrophages/immunology ; Macrophages/metabolism ; Monocytes/cytology ; Monocytes/metabolism ; Nitric Oxide Synthase Type III/genetics ; Nitric Oxide Synthase Type III/metabolism ; Pertussis Toxin/pharmacology ; Physostigmine/analogs & derivatives ; Physostigmine/pharmacology ; Quinolones/pharmacology ; Receptors, G-Protein-Coupled/agonists
Czasopismo naukowe
Tytuł :
Interplay of the red blood cell and vascular endothelial nitric oxide synthase system to combat cardiac complications of anemia.
Autorzy :
Daiber A; Center for Cardiology, Cardiology I, University Medical Center Mainz, Geb. 605, Langenbeckstr. 1, 55131, Mainz, Germany. .; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany. .
Münzel T; Center for Cardiology, Cardiology I, University Medical Center Mainz, Geb. 605, Langenbeckstr. 1, 55131, Mainz, Germany. .; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany. .
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Źródło :
Basic research in cardiology [Basic Res Cardiol] 2020 Jun 12; Vol. 115 (4), pp. 44. Date of Electronic Publication: 2020 Jun 12.
Typ publikacji :
Editorial; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Anemia*
Nitric Oxide Synthase*
Endothelium, Vascular ; Erythrocytes ; Humans ; Nitric Oxide Synthase Type III
Raport
Tytuł :
Hypoglycemia increases endothelial-dependent vasodilation through suppressing phosphorylation at Threonine 495/497 site of endothelial nitric oxide synthase.
Autorzy :
He A; Division of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Zuo D; Division of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Liang X; Division of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Guo Y; Division of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Suxin L; Division of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China. Electronic address: .
Xia Y; Division of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China; Institute of Life Science, Chongqing Medical University, Chongqing 400016, China. Electronic address: .
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Źródło :
Microvascular research [Microvasc Res] 2021 Jan; Vol. 133, pp. 104075. Date of Electronic Publication: 2020 Sep 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Vasodilation*
Aorta, Thoracic/*enzymology
Endothelial Cells/*enzymology
Hypoglycemia/*enzymology
Mesenteric Arteries/*enzymology
Nitric Oxide Synthase Type III/*metabolism
AMP-Activated Protein Kinases/genetics ; AMP-Activated Protein Kinases/metabolism ; Animals ; Aorta, Thoracic/physiopathology ; Blood Glucose/metabolism ; Cattle ; Cells, Cultured ; Disease Models, Animal ; Female ; Hypoglycemia/physiopathology ; Male ; Mesenteric Arteries/physiopathology ; Nitric Oxide/blood ; Phosphorylation ; Protein Kinase C-alpha/genetics ; Protein Kinase C-alpha/metabolism ; Rats, Sprague-Dawley ; Signal Transduction
Czasopismo naukowe
Tytuł :
Potential roles of neuronal nitric oxide synthase and the PTEN-induced kinase 1 (PINK1)/Parkin pathway for mitochondrial protein degradation in disuse-induced soleus muscle atrophy in adult rats.
Autorzy :
Uda M; School of Nursing, Hirosaki Gakuin University, Hirosaki, Aomori, Japan.
Yoshihara T; Graduate School of Health and Sports Science, Juntendo University, Inzai, Chiba, Japan.
Ichinoseki-Sekine N; Graduate School of Health and Sports Science, Juntendo University, Inzai, Chiba, Japan.; Faculty of Liberal Arts, The Open University of Japan, Chiba, Japan.
Baba T; School of Medicine, Juntendo University, Inzai, Chiba, Japan.
Yoshioka T; School of Nursing, Hirosaki Gakuin University, Hirosaki, Aomori, Japan.
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Źródło :
PloS one [PLoS One] 2020 Dec 09; Vol. 15 (12), pp. e0243660. Date of Electronic Publication: 2020 Dec 09 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mitochondria/*pathology
Muscular Atrophy/*pathology
Nitric Oxide Synthase Type I/*metabolism
Protein Kinases/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Animals ; Disease Models, Animal ; GTP Phosphohydrolases/metabolism ; Hindlimb Suspension/adverse effects ; Humans ; Male ; Malondialdehyde/metabolism ; Mitochondrial Proteins/metabolism ; Mitophagy ; Muscle, Skeletal/pathology ; Muscular Atrophy/etiology ; Nitric Oxide/metabolism ; Proteolysis ; Rats ; Ubiquitination
Czasopismo naukowe
Tytuł :
Hypertension is associated with blunted NO-mediated leg vasodilator responsiveness that is reversed by high-intensity training in postmenopausal women.
Autorzy :
Gunnarsson TP; Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
Ehlers TS; Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
Baasch-Skytte T; Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
Lund AP; Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
Tamariz-Ellemann A; Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
Gliemann L; Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
Nyberg M; Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
Bangsbo J; Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
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Źródło :
American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] 2020 Dec 01; Vol. 319 (6), pp. R712-R723. Date of Electronic Publication: 2020 Oct 14.
Typ publikacji :
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
High-Intensity Interval Training*
Postmenopause*
Vasodilation*/drug effects
Hypertension/*therapy
Lower Extremity/*blood supply
Nitric Oxide/*metabolism
Acetylcholine/administration & dosage ; Age Factors ; Aged ; Female ; Humans ; Hypertension/metabolism ; Hypertension/physiopathology ; Middle Aged ; Nitric Oxide Donors/administration & dosage ; Nitroprusside/administration & dosage ; Oxidative Stress ; Sex Factors ; Time Factors ; Treatment Outcome ; Vasodilator Agents/administration & dosage
Czasopismo naukowe
Tytuł :
Design, synthesis and molecular modeling of novel aryl carboximidamides and 3-aryl-1,2,4-oxadiazoles derived from indomethacin as potent anti-inflammatory iNOS/PGE2 inhibitors.
Autorzy :
Mohamed MFA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, 82524 Sohag, Egypt. Electronic address: .
Marzouk AA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 71524 Assiut, Egypt.
Nafady A; Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
El-Gamal DA; Histology Department, Faculty of Medicine, Assiut University, 71526 Assiut, Egypt.
Allam RM; Pharmacology Department, National Research Centre, Giza 11865, Egypt.
Abuo-Rahma GEA; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.
El Subbagh HI; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, 35516 Mansoura, Egypt.
Moustafa AH; Department of Chemistry, Faculty of Science, Sohag University, Sohag 82524, Egypt.
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2020 Dec; Vol. 105, pp. 104439. Date of Electronic Publication: 2020 Oct 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Inflammatory Agents, Non-Steroidal/*chemical synthesis
Dinoprostone/*antagonists & inhibitors
Enzyme Inhibitors/*chemical synthesis
Indomethacin/*chemistry
Nitric Oxide Synthase Type II/*antagonists & inhibitors
Oxadiazoles/*chemical synthesis
Animals ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/pharmacokinetics ; Carrageenan/chemistry ; Celecoxib/metabolism ; Dose-Response Relationship, Drug ; Edema/drug therapy ; Enzyme Inhibitors/administration & dosage ; Enzyme Inhibitors/pharmacokinetics ; Humans ; Lipopolysaccharides/chemistry ; Male ; Mice ; Molecular Docking Simulation ; Molecular Structure ; Nitric Oxide/metabolism ; Oxadiazoles/administration & dosage ; Oxadiazoles/pharmacokinetics ; Oximes/chemistry ; RAW 264.7 Cells ; Rats
Czasopismo naukowe
Tytuł :
Tetrahydrobiopterin prevents chronic ischemia-related lower urinary tract dysfunction through the maintenance of nitric oxide bioavailability.
Autorzy :
Akaihata H; Department of Urology, Fukushima Medical University of School of Medicine, Fukushima, 960-1295, Japan. .
Hata J; Department of Urology, Fukushima Medical University of School of Medicine, Fukushima, 960-1295, Japan.
Tanji R; Department of Urology, Fukushima Medical University of School of Medicine, Fukushima, 960-1295, Japan.
Honda-Takinami R; Department of Urology, Fukushima Medical University of School of Medicine, Fukushima, 960-1295, Japan.
Matsuoka K; Department of Urology, Fukushima Medical University of School of Medicine, Fukushima, 960-1295, Japan.
Sato Y; Department of Urology, Fukushima Medical University of School of Medicine, Fukushima, 960-1295, Japan.
Kataoka M; Department of Urology, Fukushima Medical University of School of Medicine, Fukushima, 960-1295, Japan.
Ogawa S; Department of Urology, Fukushima Medical University of School of Medicine, Fukushima, 960-1295, Japan.
Kojima Y; Department of Urology, Fukushima Medical University of School of Medicine, Fukushima, 960-1295, Japan.
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Źródło :
Scientific reports [Sci Rep] 2020 Nov 16; Vol. 10 (1), pp. 19844. Date of Electronic Publication: 2020 Nov 16.
Typ publikacji :
Journal Article
MeSH Terms :
Biopterin/*analogs & derivatives
Ischemia/*prevention & control
Nitric Oxide/*biosynthesis
Urinary Bladder/*blood supply
Animals ; Biological Availability ; Biopterin/administration & dosage ; Biopterin/pharmacology ; Gene Expression Regulation/drug effects ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Ischemia/etiology ; Ischemia/metabolism ; Male ; Muscle Contraction/drug effects ; Nitric Oxide Synthase Type III/metabolism ; Oxidation-Reduction ; Rats ; Rats, Sprague-Dawley ; Tetrahydrofolate Dehydrogenase/metabolism ; Urinary Bladder/drug effects
Czasopismo naukowe

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