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Tytuł :
A nitroreductase and glutathione responsive nanoplatform for integration of gene delivery and near-infrared fluorescence imaging.
Autorzy :
Liang H; National Engineering Research Center for Biomaterials, Sichuan University, No. 29, Wangjiang Road, Chengdu 610064, P. R. China. .
Bi Q
Hu A
Chen X
Jin R
Song X
Ke B
Barz M
Nie Y
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Źródło :
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2020 Jun 25; Vol. 56 (51), pp. 6949-6952.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Transfer Techniques*
Optical Imaging*
Fluorescent Dyes/*chemistry
Glutathione/*chemistry
Nitroreductases/*chemistry
Fluorescent Dyes/chemical synthesis ; Fluorescent Dyes/metabolism ; Glutathione/metabolism ; HeLa Cells ; Humans ; Indocyanine Green/chemistry ; Indocyanine Green/metabolism ; Infrared Rays ; Nitroreductases/metabolism ; Peptides/chemistry ; Peptides/metabolism
Czasopismo naukowe
Tytuł :
Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering.
Autorzy :
Lee BM; Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory, Australia.
Harold LK; Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.
Almeida DV; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Afriat-Jurnou L; Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory, Australia.; MIGAL, Galilee Research Institute, Kiryat Shmona, Israel.; Faculty of Sciences and Technology, Tel-Hai Academic College, Upper Galilee, Israel.
Aung HL; Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.
Forde BM; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.
Hards K; Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.
Pidot SJ; Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia.
Ahmed FH; Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory, Australia.
Mohamed AE; Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory, Australia.
Taylor MC; Land and Water Flagship, The Commonwealth Scientific and Industrial Organisation, Canberra, Australian Capital Territory, Australia.
West NP; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.
Stinear TP; Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia.
Greening C; Land and Water Flagship, The Commonwealth Scientific and Industrial Organisation, Canberra, Australian Capital Territory, Australia.; School of Biological Sciences, Monash University, Clayton, Victoria, Australia.
Beatson SA; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.
Nuermberger EL; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Cook GM; Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.
Jackson CJ; Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory, Australia.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Feb 07; Vol. 16 (2), pp. e1008287. Date of Electronic Publication: 2020 Feb 07 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Proteins*/genetics
Bacterial Proteins*/metabolism
Drug Resistance, Bacterial*/drug effects
Drug Resistance, Bacterial*/genetics
Mutation*
Mycobacterium tuberculosis*/genetics
Mycobacterium tuberculosis*/metabolism
Nitroreductases*/genetics
Nitroreductases*/metabolism
Protein Engineering*
Antitubercular Agents/*pharmacology
Nitroimidazoles/*pharmacology
Oxazoles/*pharmacology
Polymorphism, Genetic
Czasopismo naukowe
Tytuł :
Prodrugs for nitroreductase-based cancer therapy-3: Antitumor activity of the novel dinitroaniline prodrugs/Ssap-NtrB enzyme suicide gene system: Synthesis, in vitro and in silico evaluation in prostate cancer.
Autorzy :
Tokay E; Department of Molecular Biology and Genetic, Faculty of Sciences and Arts, Balıkesir University, Balıkesir, 10145, Turkey.
Güngör T; Department of Chemistry, Faculty of Sciences and Arts, Natural Products and Drug Research Laboratory, Çanakkale Onsekiz Mart University, Çanakkale, 17020, Turkey.
Hacıoğlu N; Department of Molecular Biology and Genetic, Faculty of Sciences and Arts, Balıkesir University, Balıkesir, 10145, Turkey.
Önder FC; Department of Chemistry, Faculty of Sciences and Arts, Natural Products and Drug Research Laboratory, Çanakkale Onsekiz Mart University, Çanakkale, 17020, Turkey.
Gülhan ÜG; Department of Chemistry, Faculty of Science, Gebze Technical University, Gebze-Kocaeli, 41400, Turkey.
Tok TT; Department of Chemistry, Faculty of Sciences and Arts, Gaziantep University, Gaziantep, 27310, Turkey.
Çelik A; Department of Chemistry, Faculty of Science, Gebze Technical University, Gebze-Kocaeli, 41400, Turkey.
Ay M; Department of Chemistry, Faculty of Sciences and Arts, Natural Products and Drug Research Laboratory, Çanakkale Onsekiz Mart University, Çanakkale, 17020, Turkey. Electronic address: .
Köçkar F; Department of Molecular Biology and Genetic, Faculty of Sciences and Arts, Balıkesir University, Balıkesir, 10145, Turkey. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2020 Feb 01; Vol. 187, pp. 111937. Date of Electronic Publication: 2019 Dec 09.
Typ publikacji :
Journal Article
MeSH Terms :
Aniline Compounds/*pharmacology
Antineoplastic Agents/*pharmacology
Enzyme Inhibitors/*pharmacology
Nitroreductases/*antagonists & inhibitors
Prodrugs/*pharmacology
Prostatic Neoplasms/*drug therapy
Aniline Compounds/chemical synthesis ; Aniline Compounds/chemistry ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Genetic Therapy ; Humans ; Male ; Models, Molecular ; Molecular Structure ; Nitroreductases/genetics ; Nitroreductases/metabolism ; Prodrugs/chemical synthesis ; Prodrugs/chemistry ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Transgenic tobacco plants overexpressing a cold-adaptive nitroreductase gene exhibited enhanced 2,4-dinitrotoluene detoxification rate at low temperature.
Autorzy :
Kayıhan DS; Department of Molecular Biology and Genetics, Gebze Technical University, Kocaeli, Turkey.
Kayıhan C; Department of Molecular Biology and Genetics, Başkent University, Ankara, Turkey.
Özden Çiftçi Y; Department of Molecular Biology and Genetics, Gebze Technical University, Kocaeli, Turkey.
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Źródło :
International journal of phytoremediation [Int J Phytoremediation] 2021; Vol. 23 (1), pp. 1-9. Date of Electronic Publication: 2020 Jul 09.
Typ publikacji :
Journal Article
MeSH Terms :
Hydrogen Peroxide*
Tobacco*
Biodegradation, Environmental ; Dinitrobenzenes ; Nitroreductases/genetics ; Plants, Genetically Modified/genetics ; Temperature
Czasopismo naukowe
Tytuł :
A mitochondria-targeting nitroreductase fluorescent probe with large Stokes shift and long-wavelength emission for imaging hypoxic status in tumor cells.
Autorzy :
Yang Q; CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, Gansu, 730000, PR China; University of Chinese Academy of Sciences, Beijing, 100049, PR China.
Wang S; CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, Gansu, 730000, PR China; University of Chinese Academy of Sciences, Beijing, 100049, PR China.
Li D; CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, Gansu, 730000, PR China.
Yuan J; CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, Gansu, 730000, PR China.
Xu J; CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, Gansu, 730000, PR China.
Shao S; CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, Gansu, 730000, PR China. Electronic address: .
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Źródło :
Analytica chimica acta [Anal Chim Acta] 2020 Mar 22; Vol. 1103, pp. 202-211. Date of Electronic Publication: 2019 Dec 24.
Typ publikacji :
Journal Article
MeSH Terms :
Benzothiazoles/*chemistry
Cell Hypoxia/*physiology
Fluorescent Dyes/*chemistry
Mitochondria/*metabolism
Nitroreductases/*analysis
Benzothiazoles/metabolism ; Benzothiazoles/toxicity ; Cell Line, Tumor ; Fluorescent Dyes/metabolism ; Fluorescent Dyes/toxicity ; Humans ; Limit of Detection ; Microscopy, Fluorescence ; Molecular Docking Simulation ; Nitroreductases/metabolism ; Protein Binding ; Pyridinium Compounds/chemistry ; Pyridinium Compounds/metabolism ; Pyridinium Compounds/toxicity ; Quinolinium Compounds/chemistry ; Quinolinium Compounds/metabolism ; Quinolinium Compounds/toxicity ; Spectrometry, Fluorescence
Czasopismo naukowe
Tytuł :
A high-selectivity fluorescent probe for hypoxia imaging in cells and a tumor-bearing mouse model.
Autorzy :
Wang Y; CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China. .
Han X
Zhang X
Zhang L
Chen L
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Źródło :
The Analyst [Analyst] 2020 Feb 17; Vol. 145 (4), pp. 1389-1395.
Typ publikacji :
Journal Article
MeSH Terms :
Tumor Hypoxia*
Brain/*enzymology
Fluorescent Dyes/*chemistry
Nitroreductases/*analysis
Optical Imaging/*methods
A549 Cells ; Animals ; Cell Hypoxia ; Cell Line, Tumor ; Cell Survival/drug effects ; Fluorescent Dyes/chemical synthesis ; Fluorescent Dyes/metabolism ; Fluorescent Dyes/toxicity ; Humans ; Limit of Detection ; Mice ; Mice, Nude ; Microscopy, Confocal ; Nitroreductases/metabolism ; Spectroscopy, Near-Infrared ; Xenograft Model Antitumor Assays ; Zebrafish
Czasopismo naukowe
Tytuł :
A novel fluorescent probe based on naphthalimide for imaging nitroreductase (NTR) in bacteria and cells.
Autorzy :
Zhang Z; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Xinong Road 22, Yangling, Shaanxi 712100, PR China.
Lv T; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Xinong Road 22, Yangling, Shaanxi 712100, PR China.
Tao B; Zhejiang Runtu Co., Ltd, No. 1 Building of Wealth Square, No. 1009 Shimin Avenue Shangyu City, Zhejiang 312368, PR China.
Wen Z; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Xinong Road 22, Yangling, Shaanxi 712100, PR China.
Xu Y; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Xinong Road 22, Yangling, Shaanxi 712100, PR China.
Li H; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Xinong Road 22, Yangling, Shaanxi 712100, PR China.
Liu F; State Key Laboratory of Fine Chemicals, School of Chemistry, Dalian University of Technology, No. 2 Linggong Road, Ganjingzi District, Dalian 116023, PR China. Electronic address: .
Sun S; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Xinong Road 22, Yangling, Shaanxi 712100, PR China. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2020 Feb 01; Vol. 28 (3), pp. 115280. Date of Electronic Publication: 2019 Dec 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Optical Imaging*
Escherichia coli/*enzymology
Fluorescent Dyes/*chemistry
Naphthalimides/*chemistry
Nitroreductases/*analysis
Staphylococcus aureus/*enzymology
Cell Line ; Fluorescent Dyes/chemical synthesis ; Hep G2 Cells ; Humans ; MCF-7 Cells ; Naphthalimides/chemical synthesis ; Nitroreductases/metabolism
Czasopismo naukowe
Tytuł :
A novel cold-adapted nitroreductase from Psychrobactersp. ANT206: Heterologous expression, characterization and nitrobenzene reduction capacity.
Autorzy :
Wang Y; School of Environment, Harbin Institute of Technology, Harbin 150090, PR China.
Hou Y; School of Marine Science and Technology, Harbin Institute of Technology, Weihai 264209, PR China. Electronic address: .
Wang Y; School of Environment, Harbin Institute of Technology, Harbin 150090, PR China.
Zheng L; School of Marine Science and Technology, Harbin Institute of Technology, Weihai 264209, PR China.
Wang Q; School of Environment, Harbin Institute of Technology, Harbin 150090, PR China; School of Marine Science and Technology, Harbin Institute of Technology, Weihai 264209, PR China. Electronic address: .
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Źródło :
Enzyme and microbial technology [Enzyme Microb Technol] 2019 Dec; Vol. 131, pp. 109434. Date of Electronic Publication: 2019 Sep 19.
Typ publikacji :
Journal Article
MeSH Terms :
Cold Temperature*
Nitrobenzenes/*metabolism
Nitroreductases/*isolation & purification
Nitroreductases/*metabolism
Psychrobacter/*enzymology
Biotransformation ; Cloning, Molecular ; Computational Biology ; Environmental Pollutants/metabolism ; Enzyme Stability ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Kinetics ; Nitroreductases/chemistry ; Nitroreductases/genetics ; Oxidation-Reduction ; Protein Conformation ; Psychrobacter/genetics ; Sodium Chloride/metabolism
Czasopismo naukowe
Tytuł :
Identification of a Novel Nitroreductase LNR and Its Role in Pendimethalin Catabolism in Bacillus subtilis Y3.
Autorzy :
Ni H; College of Life Sciences , Jiangxi Normal University , Nanchang , Jiangxi 330022 , China.
Li N; School of Life Science and Technology , Nanyang Normal University , Nanyang , Henan 473061 , China.
Qian M; Laboratory Center of Life Science, College of Life Sciences , Nanjing Agricultural University , Nanjing , Jiangsu 210095 , China.
He J; Laboratory Center of Life Science, College of Life Sciences , Nanjing Agricultural University , Nanjing , Jiangsu 210095 , China.
Chen Q; College of Life Sciences , Zaozhuang University , Zaozhuang , Shandong 277160 , China.
Huang Y; College of Life Sciences , Jiangxi Normal University , Nanchang , Jiangxi 330022 , China.
Zou L; College of Life Sciences , Jiangxi Normal University , Nanchang , Jiangxi 330022 , China.
Long ZE; College of Life Sciences , Jiangxi Normal University , Nanchang , Jiangxi 330022 , China.
Wang F; Jiangxi Engineering Laboratory for the Development and Utilization of Agricultural Microbial Resources, College of Bioscience and Bioengineering , Jiangxi Agricultural University , Nanchang , Jiangxi 330045 , China.
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Źródło :
Journal of agricultural and food chemistry [J Agric Food Chem] 2019 Nov 20; Vol. 67 (46), pp. 12816-12823. Date of Electronic Publication: 2019 Nov 12.
Typ publikacji :
Journal Article
MeSH Terms :
Aniline Compounds/*metabolism
Bacillus subtilis/*enzymology
Bacterial Proteins/*metabolism
Herbicides/*metabolism
Nitroreductases/*metabolism
Amino Acid Sequence ; Aniline Compounds/chemistry ; Bacillus subtilis/classification ; Bacillus subtilis/genetics ; Bacillus subtilis/metabolism ; Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Biodegradation, Environmental ; Herbicides/chemistry ; Nitroreductases/chemistry ; Nitroreductases/genetics ; Phylogeny ; Sequence Alignment
Czasopismo naukowe
Tytuł :
Degradation of High Energy Materials Using Biological Reduction: A Rational Way to Reach Bioremediation.
Autorzy :
Aguero S; PRABI-LG-Tissue Biology and Therapeutic Engineering Laboratory (LBTI) UMR UCBL CNRS 5305, University of Lyon. 7 Passage du Vercors, CEDEX 07, 69367 Lyon, France.
Terreux R; PRABI-LG-Tissue Biology and Therapeutic Engineering Laboratory (LBTI) UMR UCBL CNRS 5305, University of Lyon. 7 Passage du Vercors, CEDEX 07, 69367 Lyon, France.; Pharmaceutical and biological Research Institute (ISPB), CEDEX 07, 69367 Lyon, France.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2019 Nov 07; Vol. 20 (22). Date of Electronic Publication: 2019 Nov 07.
Typ publikacji :
Journal Article
MeSH Terms :
Azocines*/chemistry
Azocines*/metabolism
Bacterial Proteins*/chemistry
Bacterial Proteins*/metabolism
Explosive Agents*/chemistry
Explosive Agents*/metabolism
Nitroreductases*/chemistry
Nitroreductases*/metabolism
Enterobacter cloacae/*enzymology
Biodegradation, Environmental
Czasopismo naukowe
Tytuł :
Evaluating the level of nitroreductase activity in clinical Klebsiella pneumoniae isolates to support strategies for nitro drug and prodrug development.
Autorzy :
Wand ME; Public Health England, Technology Development Group, Research and Development Institute, National Infection Service, Porton Down, Salisbury, Wiltshire SP4 0JG, UK.
Taylor HV; Public Health England, Technology Development Group, Research and Development Institute, National Infection Service, Porton Down, Salisbury, Wiltshire SP4 0JG, UK.
Auer JL; Institute of Pharmaceutical Science, King's College London, London SE1 9NH, UK.
Bock LJ; Public Health England, Technology Development Group, Research and Development Institute, National Infection Service, Porton Down, Salisbury, Wiltshire SP4 0JG, UK.
Hind CK; Public Health England, Technology Development Group, Research and Development Institute, National Infection Service, Porton Down, Salisbury, Wiltshire SP4 0JG, UK.
Jamshidi S; Institute of Pharmaceutical Science, King's College London, London SE1 9NH, UK.
Rahman KM; Institute of Pharmaceutical Science, King's College London, London SE1 9NH, UK.
Sutton JM; Public Health England, Technology Development Group, Research and Development Institute, National Infection Service, Porton Down, Salisbury, Wiltshire SP4 0JG, UK. Electronic address: .
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Źródło :
International journal of antimicrobial agents [Int J Antimicrob Agents] 2019 Nov; Vol. 54 (5), pp. 538-546. Date of Electronic Publication: 2019 Aug 06.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Bacterial Agents/*pharmacology
Klebsiella pneumoniae/*drug effects
Nitroreductases/*analysis
Nitroreductases/*metabolism
Prodrugs/*pharmacology
Gene Expression Regulation, Bacterial/genetics ; Genetic Variation/genetics ; Humans ; Klebsiella pneumoniae/genetics ; Klebsiella pneumoniae/isolation & purification ; Molecular Docking Simulation ; Nitroreductases/genetics ; Protein Binding
Czasopismo naukowe
Tytuł :
Evolving a Unique Red-Emitting Fluorophore with an Optically Tunable Hydroxy Group for Imaging Nitroreductase in Cells, in Tissues, and in Vivo.
Autorzy :
Peng R; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering , Hunan University , Changsha 410082 P. R. China.
Yuan J; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering , Hunan University , Changsha 410082 P. R. China.
Cheng D; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering , Hunan University , Changsha 410082 P. R. China.
Ren T; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering , Hunan University , Changsha 410082 P. R. China.
Jin F; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering , Hunan University , Changsha 410082 P. R. China.
Yang R; School of Chemistry and Biological Engineering , Changsha University of Science and Technology , Changsha , P. R. China.
Yuan L; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering , Hunan University , Changsha 410082 P. R. China.
Zhang X; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering , Hunan University , Changsha 410082 P. R. China.
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Źródło :
Analytical chemistry [Anal Chem] 2019 Dec 17; Vol. 91 (24), pp. 15974-15981. Date of Electronic Publication: 2019 Dec 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Fluorescent Dyes/*chemistry
Nitroreductases/*metabolism
Optical Imaging/*methods
Animals ; Female ; Fluorescent Dyes/metabolism ; HeLa Cells ; Humans ; Mice ; Mice, Inbred BALB C ; Microscopy, Confocal/methods ; Neoplasms/diagnostic imaging ; Nitroreductases/chemistry ; Photons ; Tumor Hypoxia
Czasopismo naukowe
Tytuł :
An efficient fluorescence sensor for nitroreductase selective imaging based on intramolecular photoinduced electron transfer.
Autorzy :
Zhang N; State Key Laboratory of Bioactive Substances and Function of Natural Medicine, Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; School of Life and Environment Sciences, Harbin University of Commerce, Harbin 150076, China.
Wang Y; State Key Laboratory of Bioactive Substances and Function of Natural Medicine, Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; School of Life and Environment Sciences, Harbin University of Commerce, Harbin 150076, China.
Leng S; State Key Laboratory of Bioactive Substances and Function of Natural Medicine, Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Xu S; State Key Laboratory of Bioactive Substances and Function of Natural Medicine, Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Zhang L; State Key Laboratory of Bioactive Substances and Function of Natural Medicine, Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Wang Q; State Key Laboratory of Bioactive Substances and Function of Natural Medicine, Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Zhang Q; State Key Laboratory of Bioactive Substances and Function of Natural Medicine, Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. Electronic address: .
Hu HY; State Key Laboratory of Bioactive Substances and Function of Natural Medicine, Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. Electronic address: .
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Źródło :
Talanta [Talanta] 2019 Dec 01; Vol. 205, pp. 120133. Date of Electronic Publication: 2019 Jul 09.
Typ publikacji :
Journal Article
MeSH Terms :
Optical Imaging*
Photochemical Processes*
Nitroreductases/*metabolism
Spectrometry, Fluorescence/*instrumentation
Carbocyanines/chemistry ; Electron Transport ; Hydrogen-Ion Concentration ; Methicillin-Resistant Staphylococcus aureus/metabolism ; Nitroreductases/antagonists & inhibitors ; Temperature
Czasopismo naukowe
Tytuł :
Novel 5-Nitrofuran-Activating Reductase in Escherichia coli.
Autorzy :
Le VVH; School of Fundamental Sciences, Massey University, Palmerston North, New Zealand.
Davies IG; New Zealand Pharmaceuticals Ltd., Palmerston North, New Zealand.
Moon CD; AgResearch Limited, Grasslands Research Centre, Palmerston North, New Zealand.
Wheeler D; School of Fundamental Sciences, Massey University, Palmerston North, New Zealand.
Biggs PJ; School of Fundamental Sciences, Massey University, Palmerston North, New Zealand.; EpiLab, Infectious Disease Research Centre, School of Veterinary Science, Massey University, Palmerston North, New Zealand.
Rakonjac J; School of Fundamental Sciences, Massey University, Palmerston North, New Zealand .
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Źródło :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2019 Oct 22; Vol. 63 (11). Date of Electronic Publication: 2019 Oct 22 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Escherichia coli/*enzymology
Nitroreductases/*metabolism
Anti-Bacterial Agents/metabolism ; Anti-Bacterial Agents/pharmacology ; Drug Resistance, Bacterial/genetics ; Escherichia coli/drug effects ; Escherichia coli/genetics ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; Furazolidone/chemistry ; Furazolidone/pharmacology ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Nitrofurans/metabolism ; Nitrofurans/pharmacology ; Nitrofurantoin/chemistry ; Nitrofurantoin/pharmacology ; Nitrofurazone/chemistry ; Nitrofurazone/pharmacology ; Nitroreductases/genetics ; Peroxiredoxins/genetics ; Peroxiredoxins/metabolism
Czasopismo naukowe
Tytuł :
A cofactor consumption screen identifies promising NfsB family nitroreductases for dinitrotoluene remediation.
Autorzy :
Williams EM; School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand.; Department of Chemistry, Emory University, Atlanta, GA, USA.
Sharrock AV; School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand.; Centre for Biodiscovery, Victoria University of Wellington, Wellington, New Zealand.
Rylott EL; Department of Biology, Centre for Novel Agricultural Products, University of York, York, YO10 5DD, UK.
Bruce NC; Department of Biology, Centre for Novel Agricultural Products, University of York, York, YO10 5DD, UK.
MacKichan JK; School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand.; Centre for Biodiscovery, Victoria University of Wellington, Wellington, New Zealand.
Ackerley DF; School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand. .; Centre for Biodiscovery, Victoria University of Wellington, Wellington, New Zealand. .
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Źródło :
Biotechnology letters [Biotechnol Lett] 2019 Oct; Vol. 41 (10), pp. 1155-1162. Date of Electronic Publication: 2019 Aug 07.
Typ publikacji :
Journal Article
MeSH Terms :
Biodegradation, Environmental*
Bacillus subtilis/*enzymology
Dinitrobenzenes/*metabolism
Environmental Pollutants/*metabolism
Nitroreductases/*analysis
Vibrio vulnificus/*enzymology
Kinetics ; Nitroreductases/isolation & purification ; Oxidation-Reduction
Czasopismo naukowe
Tytuł :
Nitroreductases of bacterial origin in Giardia lamblia: Potential role in detoxification of xenobiotics.
Autorzy :
Müller J; Vetsuisse Faculty, Institute of Parasitology, University of Berne, Berne, Switzerland.
Müller N; Vetsuisse Faculty, Institute of Parasitology, University of Berne, Berne, Switzerland.
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Źródło :
MicrobiologyOpen [Microbiologyopen] 2019 Oct; Vol. 8 (10), pp. e904. Date of Electronic Publication: 2019 Jul 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Inactivation, Metabolic*
Giardia lamblia/*enzymology
Nitroreductases/*metabolism
Xenobiotics/*metabolism
Anaerobiosis ; Dinitrobenzenes/metabolism ; Escherichia coli/drug effects ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Giardia lamblia/genetics ; Microbial Sensitivity Tests ; Nitroreductases/genetics ; Oxidation-Reduction ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Tetracycline/metabolism ; Vitamin K 3/metabolism
Czasopismo naukowe
Tytuł :
The Pseudomonas putida NfnB nitroreductase confers resistance to roxarsone.
Autorzy :
Chen J; Department of Cellular Biology and Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, United States; Research Center for Soil Contamination and Environmental Remediation, Southwest Forestry University, Kunming, Yunnan 650224, China.
Rosen BP; Department of Cellular Biology and Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, United States. Electronic address: .
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Źródło :
The Science of the total environment [Sci Total Environ] 2020 Dec 15; Vol. 748, pp. 141339. Date of Electronic Publication: 2020 Aug 01.
Typ publikacji :
Journal Article
MeSH Terms :
Arsenic*
Arsenicals*
Pseudomonas putida*/genetics
Roxarsone*/toxicity
Animals ; Nitroreductases/genetics ; Swine
Czasopismo naukowe
Tytuł :
Engineering Escherichia coli NfsB To Activate a Hypoxia-Resistant Analogue of the PET Probe EF5 To Enable Non-Invasive Imaging during Enzyme Prodrug Therapy.
Autorzy :
Williams EM; School of Biological Sciences , Victoria University of Wellington , Wellington 6012 , New Zealand.
Rich MH; School of Biological Sciences , Victoria University of Wellington , Wellington 6012 , New Zealand.
Mowday AM; Auckland Cancer Society Research Centre, School of Medical Sciences , The University of Auckland , Auckland 1023 , New Zealand.
Ashoorzadeh A; Auckland Cancer Society Research Centre, School of Medical Sciences , The University of Auckland , Auckland 1023 , New Zealand.
Copp JN; School of Biological Sciences , Victoria University of Wellington , Wellington 6012 , New Zealand.
Guise CP; Auckland Cancer Society Research Centre, School of Medical Sciences , The University of Auckland , Auckland 1023 , New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery , Auckland 1023 , New Zealand.
Anderson RF; Auckland Cancer Society Research Centre, School of Medical Sciences , The University of Auckland , Auckland 1023 , New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery , Auckland 1023 , New Zealand.
Flanagan JU; Auckland Cancer Society Research Centre, School of Medical Sciences , The University of Auckland , Auckland 1023 , New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery , Auckland 1023 , New Zealand.
Smaill JB; Auckland Cancer Society Research Centre, School of Medical Sciences , The University of Auckland , Auckland 1023 , New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery , Auckland 1023 , New Zealand.
Patterson AV; Auckland Cancer Society Research Centre, School of Medical Sciences , The University of Auckland , Auckland 1023 , New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery , Auckland 1023 , New Zealand.
Ackerley DF; School of Biological Sciences , Victoria University of Wellington , Wellington 6012 , New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery , Auckland 1023 , New Zealand.
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Źródło :
Biochemistry [Biochemistry] 2019 Sep 03; Vol. 58 (35), pp. 3700-3710. Date of Electronic Publication: 2019 Aug 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Monitoring/*methods
Escherichia coli Proteins/*metabolism
Etanidazole/*analogs & derivatives
Hydrocarbons, Fluorinated/*metabolism
Molecular Imaging/*methods
Nitroreductases/*metabolism
Positron-Emission Tomography/*methods
Prodrugs/*therapeutic use
Antineoplastic Agents/therapeutic use ; Biosensing Techniques/methods ; Cell Hypoxia/physiology ; Enzyme Activation ; Escherichia coli/enzymology ; Escherichia coli/genetics ; Escherichia coli Proteins/genetics ; Etanidazole/chemistry ; Etanidazole/metabolism ; Genetic Therapy/methods ; HCT116 Cells ; Humans ; Hydrocarbons, Fluorinated/chemistry ; Imidazoles/pharmacology ; Imidazoles/therapeutic use ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Neoplasms/pathology ; Nitroreductases/genetics ; Prodrugs/metabolism ; Protein Engineering
Czasopismo naukowe
Tytuł :
Overexpression of the nitroreductase NfsB in an E. coli strain as a whole-cell biocatalyst for the production of chlorinated analogues of the natural herbicide DIBOA.
Autorzy :
de la Calle ME; Department of Chemical Engineering and Food Technology, University of Cadiz, Campus Universitario de Puerto Real, Universidad de Cádiz, 11510, Puerto Real, Cadiz, Spain.
Cabrera G; Department of Chemical Engineering and Food Technology, University of Cadiz, Campus Universitario de Puerto Real, Universidad de Cádiz, 11510, Puerto Real, Cadiz, Spain.
Cantero D; Department of Chemical Engineering and Food Technology, University of Cadiz, Campus Universitario de Puerto Real, Universidad de Cádiz, 11510, Puerto Real, Cadiz, Spain.
Valle A; Department of Biomedicine, Biotechnology and Public Health-Biochemistry and Molecular Biology, University of Cadiz, Campus Universitario de Puerto Real, Universidad de Cádiz, 11510, Puerto Real, Cadiz, Spain. Electronic address: .
Bolivar J; Department of Biomedicine, Biotechnology and Public Health-Biochemistry and Molecular Biology, University of Cadiz, Campus Universitario de Puerto Real, Universidad de Cádiz, 11510, Puerto Real, Cadiz, Spain. Electronic address: .
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Źródło :
New biotechnology [N Biotechnol] 2019 May 25; Vol. 50, pp. 9-19. Date of Electronic Publication: 2019 Jan 07.
Typ publikacji :
Journal Article
MeSH Terms :
Benzoxazines/*metabolism
Biological Products/*metabolism
Escherichia coli/*enzymology
Escherichia coli Proteins/*biosynthesis
Nitroreductases/*biosynthesis
Benzoxazines/chemistry ; Biocatalysis ; Biological Products/chemistry ; Biotransformation ; Escherichia coli/metabolism ; Escherichia coli Proteins/metabolism ; Halogenation ; Kinetics ; Molecular Structure ; Nitroreductases/metabolism
Czasopismo naukowe
Tytuł :
PRODRUGS FOR NITROREDUCTASE BASED CANCER THERAPY- 2: Novel amide/Ntr combinations targeting PC3 cancer cells.
Autorzy :
Güngör T; Department of Chemistry, Faculty of Sciences and Arts, Natural Products and Drug Research Laboratory, Çanakkale Onsekiz Mart University, Çanakkale, 17020, Turkey.
Önder FC; Department of Chemistry, Faculty of Sciences and Arts, Natural Products and Drug Research Laboratory, Çanakkale Onsekiz Mart University, Çanakkale, 17020, Turkey.
Tokay E; Department of Molecular Biology and Genetic, Faculty of Sciences and Arts, Balıkesir University, Balıkesir, 10145, Turkey.
Gülhan ÜG; Department of Chemistry, Faculty of Science, Gebze Technical University, Gebze, Kocaeli, 41400, Turkey.
Hacıoğlu N; Department of Molecular Biology and Genetic, Faculty of Sciences and Arts, Balıkesir University, Balıkesir, 10145, Turkey.
Tok TT; Department of Chemistry, Faculty of Sciences and Arts, Gaziantep University, Gaziantep, 27310, Turkey.
Çelik A; Department of Chemistry, Faculty of Science, Gebze Technical University, Gebze, Kocaeli, 41400, Turkey.
Köçkar F; Department of Molecular Biology and Genetic, Faculty of Sciences and Arts, Balıkesir University, Balıkesir, 10145, Turkey.
Ay M; Department of Chemistry, Faculty of Sciences and Arts, Natural Products and Drug Research Laboratory, Çanakkale Onsekiz Mart University, Çanakkale, 17020, Turkey. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2019 Jun 01; Vol. 171, pp. 383-400. Date of Electronic Publication: 2019 Mar 23.
Typ publikacji :
Journal Article
MeSH Terms :
Amides/*pharmacology
Antineoplastic Agents, Phytogenic/*pharmacology
Nitroreductases/*metabolism
Prodrugs/*pharmacology
Amides/chemical synthesis ; Amides/chemistry ; Antineoplastic Agents, Phytogenic/chemical synthesis ; Antineoplastic Agents, Phytogenic/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Chromatography, High Pressure Liquid ; Dose-Response Relationship, Drug ; Drug Discovery ; Drug Screening Assays, Antitumor ; Humans ; Molecular Dynamics Simulation ; Molecular Structure ; Nitroreductases/chemistry ; PC-3 Cells ; Prodrugs/chemical synthesis ; Prodrugs/chemistry ; Structure-Activity Relationship
Czasopismo naukowe

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