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Tytuł :
Nociceptive nerves regulate haematopoietic stem cell mobilization.
Autorzy :
Gao X; Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, New York, NY, USA.; Department of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA.
Zhang D; Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, New York, NY, USA.; Department of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA.
Xu C; Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, New York, NY, USA.; Department of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA.
Li H; Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, New York, NY, USA.; Department of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA.
Caron KM; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Frenette PS; Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, New York, NY, USA. .; Department of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA. .; Department of Medicine, Albert Einstein College of Medicine, New York, NY, USA. .
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Źródło :
Nature [Nature] 2021 Jan; Vol. 589 (7843), pp. 591-596. Date of Electronic Publication: 2020 Dec 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Autonomic Pathways*/drug effects
Cell Movement*/drug effects
Hematopoietic Stem Cells/*cytology
Nociception/*physiology
Nociceptors/*physiology
Sympathetic Nervous System/*cytology
Adenylyl Cyclases/metabolism ; Animals ; Calcitonin Gene-Related Peptide/metabolism ; Calcitonin Receptor-Like Protein/metabolism ; Capsaicin/pharmacology ; Cyclic AMP/metabolism ; Female ; GTP-Binding Protein alpha Subunits, Gs/metabolism ; Granulocyte Colony-Stimulating Factor/metabolism ; Hematopoietic Stem Cells/drug effects ; Hematopoietic Stem Cells/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Nociception/drug effects ; Nociceptors/drug effects ; Receptor Activity-Modifying Protein 1/metabolism ; Signal Transduction/drug effects ; Stem Cell Niche ; Sympathetic Nervous System/drug effects
Czasopismo naukowe
Tytuł :
Acute activation of bronchopulmonary vagal nociceptors by type I interferons.
Autorzy :
Patil MJ; The Johns Hopkins School of Medicine Departments of Medicine, Baltimore, MD.
Ru F; The Johns Hopkins School of Medicine Departments of Medicine, Baltimore, MD.
Sun H; The Johns Hopkins School of Medicine Departments of Medicine, Baltimore, MD.
Wang J; AstraZeneca BioPharmaceuticals R&D Gaithersburg, MD.
Kolbeck RR; AstraZeneca BioPharmaceuticals R&D Gaithersburg, MD.
Dong X; The Johns Hopkins School of Medicine Departments of Neuroscience, Baltimore, MD.
Kollarik M; The Johns Hopkins School of Medicine Departments of Medicine, Baltimore, MD.
Canning BJ; The Johns Hopkins School of Medicine Departments of Medicine, Baltimore, MD.
Undem BJ; The Johns Hopkins School of Medicine Departments of Medicine, Baltimore, MD.
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Źródło :
The Journal of physiology [J Physiol] 2020 Dec; Vol. 598 (23), pp. 5541-5554. Date of Electronic Publication: 2020 Sep 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Interferon Type I*
Nociceptors*
Animals ; Bronchi ; Mice ; Neurons, Afferent ; Nodose Ganglion ; Vagus Nerve
Czasopismo naukowe
Tytuł :
Contribution of T-Type Calcium Channels to Spinal Cord Injury-Induced Hyperexcitability of Nociceptors.
Autorzy :
Lauzadis J; Graduate Program in Molecular and Cellular Pharmacology, Department of Pharmacology, Stony Brook Medicine, Stony Brook, NY 11794.
Liu H; Department of Anesthesiology, HSC L4-076, Stony Brook Medicine, Stony Brook, NY 11794.
Lu Y; Department of Anesthesiology, HSC L4-076, Stony Brook Medicine, Stony Brook, NY 11794.
Rebecchi MJ; Department of Anesthesiology, HSC L4-076, Stony Brook Medicine, Stony Brook, NY 11794.
Kaczocha M; Department of Anesthesiology, HSC L4-076, Stony Brook Medicine, Stony Brook, NY 11794.
Puopolo M; Department of Anesthesiology, HSC L4-076, Stony Brook Medicine, Stony Brook, NY 11794 .
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2020 Sep 16; Vol. 40 (38), pp. 7229-7240. Date of Electronic Publication: 2020 Aug 24.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Action Potentials*
Nociception*
Calcium Channels, T-Type/*metabolism
Nociceptors/*metabolism
Spinal Cord Injuries/*metabolism
Animals ; Male ; Nociceptors/physiology ; Rats ; Rats, Sprague-Dawley ; Spinal Cord Injuries/physiopathology
Czasopismo naukowe
Tytuł :
Nociceptive mechanisms driving pain in a post-traumatic osteoarthritis mouse model.
Autorzy :
Alves CJ; Neuro-Skeletal Circuits Group, Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Rua Alfredo Allen, 208, 4200-135, Porto, Portugal. .; Instituto de Engenharia Biomédica (INEB), Universidade do Porto, Porto, Portugal. .
Couto M; Neuro-Skeletal Circuits Group, Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Rua Alfredo Allen, 208, 4200-135, Porto, Portugal.; Instituto de Engenharia Biomédica (INEB), Universidade do Porto, Porto, Portugal.
Sousa DM; Neuro-Skeletal Circuits Group, Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Rua Alfredo Allen, 208, 4200-135, Porto, Portugal.; Instituto de Engenharia Biomédica (INEB), Universidade do Porto, Porto, Portugal.
Magalhães A; Neuro-Skeletal Circuits Group, Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Rua Alfredo Allen, 208, 4200-135, Porto, Portugal.; Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal.
Neto E; Neuro-Skeletal Circuits Group, Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Rua Alfredo Allen, 208, 4200-135, Porto, Portugal.; Instituto de Engenharia Biomédica (INEB), Universidade do Porto, Porto, Portugal.
Leitão L; Neuro-Skeletal Circuits Group, Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Rua Alfredo Allen, 208, 4200-135, Porto, Portugal.; Instituto de Engenharia Biomédica (INEB), Universidade do Porto, Porto, Portugal.; Instituto Ciências Biomédicas Abel Salazar (ICBAS), Universidade de Porto, Porto, Portugal.
Conceição F; Neuro-Skeletal Circuits Group, Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Rua Alfredo Allen, 208, 4200-135, Porto, Portugal.; Instituto de Engenharia Biomédica (INEB), Universidade do Porto, Porto, Portugal.; Instituto Ciências Biomédicas Abel Salazar (ICBAS), Universidade de Porto, Porto, Portugal.
Monteiro AC; Neuro-Skeletal Circuits Group, Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Rua Alfredo Allen, 208, 4200-135, Porto, Portugal.; Instituto de Engenharia Biomédica (INEB), Universidade do Porto, Porto, Portugal.
Ribeiro-da-Silva M; Neuro-Skeletal Circuits Group, Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Rua Alfredo Allen, 208, 4200-135, Porto, Portugal.; Instituto de Engenharia Biomédica (INEB), Universidade do Porto, Porto, Portugal.; Faculdade de Medicina, Universidade do Porto (FMUP), Porto, Portugal.; Serviço de Ortopedia e Traumatologia, Centro Hospitalar São João, Porto, Portugal.
Lamghari M; Neuro-Skeletal Circuits Group, Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Rua Alfredo Allen, 208, 4200-135, Porto, Portugal.; Instituto de Engenharia Biomédica (INEB), Universidade do Porto, Porto, Portugal.; Instituto Ciências Biomédicas Abel Salazar (ICBAS), Universidade de Porto, Porto, Portugal.
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Źródło :
Scientific reports [Sci Rep] 2020 Sep 17; Vol. 10 (1), pp. 15271. Date of Electronic Publication: 2020 Sep 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Nociceptors/*physiology
Osteoarthritis/*physiopathology
Pain/*physiopathology
Animals ; Calcitonin Gene-Related Peptide/metabolism ; Central Nervous System Sensitization/physiology ; Disease Models, Animal ; Ganglia, Spinal/metabolism ; Ganglia, Spinal/physiopathology ; Knee Joint/metabolism ; Knee Joint/physiopathology ; Menisci, Tibial ; Mice ; Nociceptors/metabolism ; Osteoarthritis/metabolism ; Pain/metabolism ; Peripheral Nervous System Diseases/metabolism ; Peripheral Nervous System Diseases/physiopathology
Czasopismo naukowe
Tytuł :
Endoplasmic reticulum stress in the dorsal root ganglia regulates large-conductance potassium channels and contributes to pain in a model of multiple sclerosis.
Autorzy :
Yousuf MS; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.
Samtleben S; Department of Cell Biology, University of Alberta, Edmonton, AB, Canada.
Lamothe SM; Department of Pharmacology, University of Alberta, Edmonton, AB, Canada.
Friedman TN; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.
Catuneanu A; Department of Pharmacology, University of Alberta, Edmonton, AB, Canada.
Thorburn K; Department of Pharmacology, University of Alberta, Edmonton, AB, Canada.
Desai M; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.
Tenorio G; Department of Anesthesiology and Pain Medicine, University of Alberta, Edmonton, AB, Canada.
Schenk GJ; Department of Anatomy and Neurosciences, Neuroscience Amsterdam, Amsterdam UMC, VU University Medical Center, VUmc MS Center Amsterdam, Amsterdam, The Netherlands.
Ballanyi K; Department of Physiology, University of Alberta, Edmonton, AB, Canada.
Kurata HT; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.; Department of Pharmacology, University of Alberta, Edmonton, AB, Canada.
Simmen T; Department of Cell Biology, University of Alberta, Edmonton, AB, Canada.
Kerr BJ; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.; Department of Pharmacology, University of Alberta, Edmonton, AB, Canada.; Department of Anesthesiology and Pain Medicine, University of Alberta, Edmonton, AB, Canada.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2020 Sep; Vol. 34 (9), pp. 12577-12598. Date of Electronic Publication: 2020 Jul 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endoplasmic Reticulum Stress*
Encephalomyelitis, Autoimmune, Experimental/*metabolism
Ganglia, Spinal/*metabolism
Large-Conductance Calcium-Activated Potassium Channels/*metabolism
Neuralgia/*metabolism
Nociceptors/*metabolism
Adult ; Aged ; Aged, 80 and over ; Animals ; Female ; Ganglia, Spinal/pathology ; Humans ; Mice ; Mice, Inbred C57BL ; Middle Aged ; Multiple Sclerosis/metabolism ; Multiple Sclerosis/pathology ; Netherlands ; Nociceptors/pathology
Czasopismo naukowe
Tytuł :
Sensory Nociceptive Neurons Contribute to Host Protection During Enteric Infection With Citrobacter rodentium.
Autorzy :
Ramirez VT; Department of Anatomy, Physiology, & Cell Biology, UC Davis School of Veterinary Medicine, UC Davis, Davis, California, USA.
Sladek J; Department of Anatomy, Physiology, & Cell Biology, UC Davis School of Veterinary Medicine, UC Davis, Davis, California, USA.
Godinez DR; Department of Anatomy, Physiology, & Cell Biology, UC Davis School of Veterinary Medicine, UC Davis, Davis, California, USA.
Rude KM; Department of Anatomy, Physiology, & Cell Biology, UC Davis School of Veterinary Medicine, UC Davis, Davis, California, USA.
Chicco P; Department of Anatomy, Physiology, & Cell Biology, UC Davis School of Veterinary Medicine, UC Davis, Davis, California, USA.
Murray K; Department of Anatomy, Physiology, & Cell Biology, UC Davis School of Veterinary Medicine, UC Davis, Davis, California, USA.
Brust-Mascher I; Department of Anatomy, Physiology, & Cell Biology, UC Davis School of Veterinary Medicine, UC Davis, Davis, California, USA.
Gareau MG; Department of Anatomy, Physiology, & Cell Biology, UC Davis School of Veterinary Medicine, UC Davis, Davis, California, USA.
Reardon C; Department of Anatomy, Physiology, & Cell Biology, UC Davis School of Veterinary Medicine, UC Davis, Davis, California, USA.
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Źródło :
The Journal of infectious diseases [J Infect Dis] 2020 Jun 11; Vol. 221 (12), pp. 1978-1988.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Citrobacter rodentium/*immunology
Enteric Nervous System/*immunology
Enterobacteriaceae Infections/*immunology
Host-Pathogen Interactions/*immunology
Nociceptors/*immunology
Animals ; Calcitonin Gene-Related Peptide/metabolism ; Calcitonin Gene-Related Peptide Receptor Antagonists/pharmacology ; Disease Models, Animal ; Enteric Nervous System/cytology ; Enteric Nervous System/drug effects ; Enterobacteriaceae Infections/microbiology ; Host-Pathogen Interactions/drug effects ; Humans ; Intestinal Mucosa/innervation ; Intestinal Mucosa/microbiology ; Intestine, Small/innervation ; Intestine, Small/microbiology ; Mice ; Mice, Knockout ; Nociceptors/drug effects ; Nociceptors/metabolism ; Receptors, Calcitonin Gene-Related Peptide/metabolism ; TRPV Cation Channels/genetics
Czasopismo naukowe
Tytuł :
Atrophy and Death of Nonpeptidergic and Peptidergic Nociceptive Neurons in SIV Infection.
Autorzy :
Robinson JA; Department of Neuroscience, Temple University, Lewis Katz School of Medicine, Philadelphia, Pennsylvania.
Guenthner G; Department of Biology, Boston College, Chestnut Hill, Massachusetts.
Warfield R; Department of Neuroscience, Temple University, Lewis Katz School of Medicine, Philadelphia, Pennsylvania.
Kublin JR; Department of Biology, Boston College, Chestnut Hill, Massachusetts.
Smith MD; Department of Neuroscience, Temple University, Lewis Katz School of Medicine, Philadelphia, Pennsylvania.
Shekarabi M; Department of Neuroscience, Temple University, Lewis Katz School of Medicine, Philadelphia, Pennsylvania.
Miller AD; Section of Anatomic Pathology, Department of Biomedical Sciences, Cornell University College of Veterinary Medicine, Ithaca, New York.
Burdo TH; Department of Neuroscience, Temple University, Lewis Katz School of Medicine, Philadelphia, Pennsylvania. Electronic address: .
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Źródło :
The American journal of pathology [Am J Pathol] 2020 Jul; Vol. 190 (7), pp. 1530-1544. Date of Electronic Publication: 2020 Apr 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Atrophy/*pathology
Nociceptors/*pathology
Simian Acquired Immunodeficiency Syndrome/*pathology
Animals ; Anti-Retroviral Agents/pharmacology ; Ganglia, Spinal/drug effects ; Ganglia, Spinal/pathology ; Lectins/metabolism ; Macaca mulatta ; Male ; Nociceptors/drug effects ; Nociceptors/metabolism ; Polyneuropathies/pathology ; Polyneuropathies/virology ; Receptor, trkA/metabolism ; Simian Immunodeficiency Virus
Czasopismo naukowe
Tytuł :
Central mechanisms of pain in orofacial pain patients: Implications for management.
Autorzy :
Jessri M; UWA Dental School, The University of Western Australia, Nedlands, WA, Australia.
Sultan AS; Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, MD, USA.
Tavares T; Department of Oral Pathology, Radiology, and Medicine, University of Missouri, Kansas City, MO, USA.
Schug S; Anaesthesiology and Pain Medicine, UWA Medical School, University of Western Australia, Nedlands, WA, Australia.
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Źródło :
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology [J Oral Pathol Med] 2020 Jul; Vol. 49 (6), pp. 476-483. Date of Electronic Publication: 2020 Jul 02.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Facial Pain*/physiopathology
Facial Pain*/therapy
Nociceptors*
Trigeminal Nerve*/physiopathology
Humans ; Physical Stimulation
Czasopismo naukowe
Tytuł :
Transcriptional Control of the Development of Myelinated Mechano-nociceptors.
Autorzy :
Chen W; Department of Neurobiology, School of Basic Medical Sciences, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, 100069, China.
Yi M; Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, 100083, China.; Neuroscience Research Institute, Peking University, Beijing, 100083, China.; Key Laboratory for Neuroscience, Ministry of Education/National Health Commission of China, Peking University, Beijing, 100083, China.
Yang F; Department of Neurobiology, School of Basic Medical Sciences, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, 100069, China. .
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Źródło :
Neuroscience bulletin [Neurosci Bull] 2020 Jul; Vol. 36 (7), pp. 683-684. Date of Electronic Publication: 2020 Jul 02.
Typ publikacji :
Editorial; Comment
MeSH Terms :
Nociceptors*
Pain Threshold*
Humans ; Myelin Sheath ; NFI Transcription Factors ; Pain
Opinia redakcyjna
Tytuł :
Pain: Integration of Sensory and Affective Aspects of Pain.
Autorzy :
Huang J; Department of Physiology and Pharmacology, Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr. NW, Calgary, T2N 4N1, Canada.
Zhang Z; Department of Physiology and Pharmacology, Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr. NW, Calgary, T2N 4N1, Canada.
Zamponi GW; Department of Physiology and Pharmacology, Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr. NW, Calgary, T2N 4N1, Canada. Electronic address: .
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Źródło :
Current biology : CB [Curr Biol] 2020 May 04; Vol. 30 (9), pp. R393-R395.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Nociceptors*
Pain*
Brain ; Central Nervous System ; Humans ; Sensation
Czasopismo naukowe
Tytuł :
Injectable Capsaicin for the Management of Pain Due to Osteoarthritis.
Autorzy :
Campbell JN; Centrexion Therapeutics, Boston, MA 02109, USA.
Stevens R; Centrexion Therapeutics, Boston, MA 02109, USA.
Hanson P; eGenesis, Cambridge, MA 02139, USA.
Connolly J; Centrexion Therapeutics, Boston, MA 02109, USA.
Meske DS; Centrexion Therapeutics, Boston, MA 02109, USA.
Chung MK; Center to Advance Chronic Pain Research, Program in Neuroscience, The Department of Neural and Pain Sciences, School of Dentistry, University of Maryland, Baltimore, MD 21201, USA.
Lascelles BDX; Translational Research in Pain (TRiP) Program, Comparative Pain Research and Education Centre, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA.; Thurston Arthritis Centre, UNC School of Medicine, Chapel Hill, NC 27599, USA.; Center for Translational Pain Research, Department of Anesthesiology, Duke University, Durham, NC 27710, USA.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Feb 03; Vol. 26 (4). Date of Electronic Publication: 2021 Feb 03.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Capsaicin/*therapeutic use
Neuralgia/*drug therapy
Osteoarthritis/*drug therapy
TRPV Cation Channels/*antagonists & inhibitors
Animals ; Humans ; Neuralgia/metabolism ; Neuralgia/pathology ; Nociceptors/metabolism ; Nociceptors/pathology ; Osteoarthritis/metabolism ; Osteoarthritis/pathology ; TRPV Cation Channels/metabolism
Czasopismo naukowe
Tytuł :
N-palmitoyl-D-glucosamine, a Natural Monosaccharide-Based Glycolipid, Inhibits TLR4 and Prevents LPS-Induced Inflammation and Neuropathic Pain in Mice.
Autorzy :
Iannotta M; Department of Experimental Medicine, Pharmacology Division, University of Campania 'L. Vanvitelli', 80138 Naples, Italy.
Belardo C; Department of Experimental Medicine, Pharmacology Division, University of Campania 'L. Vanvitelli', 80138 Naples, Italy.
Trotta MC; Department of Experimental Medicine, Pharmacology Division, University of Campania 'L. Vanvitelli', 80138 Naples, Italy.
Iannotti FA; Institute of Biomolecular Chemistry (ICB) of National Research Council (CNR), 80078 Pozzuoli, Italy.
Vitale RM; Institute of Biomolecular Chemistry (ICB) of National Research Council (CNR), 80078 Pozzuoli, Italy.
Maisto R; Department of Experimental Medicine, Pharmacology Division, University of Campania 'L. Vanvitelli', 80138 Naples, Italy.
Boccella S; Department of Experimental Medicine, Pharmacology Division, University of Campania 'L. Vanvitelli', 80138 Naples, Italy.
Infantino R; Department of Experimental Medicine, Pharmacology Division, University of Campania 'L. Vanvitelli', 80138 Naples, Italy.
Ricciardi F; Department of Experimental Medicine, Pharmacology Division, University of Campania 'L. Vanvitelli', 80138 Naples, Italy.
Mirto BF; Department of Experimental Medicine, Pharmacology Division, University of Campania 'L. Vanvitelli', 80138 Naples, Italy.
Ferraraccio F; Pathology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania 'L. Vanvitelli', 80138 Naples, Italy.
Panarese I; Pathology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania 'L. Vanvitelli', 80138 Naples, Italy.
Amodeo P; Institute of Biomolecular Chemistry (ICB) of National Research Council (CNR), 80078 Pozzuoli, Italy.
Tunisi L; Institute of Biomolecular Chemistry (ICB) of National Research Council (CNR), 80078 Pozzuoli, Italy.
Cristino L; Institute of Biomolecular Chemistry (ICB) of National Research Council (CNR), 80078 Pozzuoli, Italy.
D'Amico M; Department of Experimental Medicine, Pharmacology Division, University of Campania 'L. Vanvitelli', 80138 Naples, Italy.
Di Marzo V; Institute of Biomolecular Chemistry (ICB) of National Research Council (CNR), 80078 Pozzuoli, Italy.; Canada Excellence Research Chair on the Microbiome-Endocannabinoidome Axis in Metabolic Health, Faculty of Medicine and Faculty of Agriculture and Food Science, Universitè Laval, Quebec City, QC G1V 0A6, Canada.
Luongo L; Department of Experimental Medicine, Pharmacology Division, University of Campania 'L. Vanvitelli', 80138 Naples, Italy.; I.R.C.S.S., Neuromed, 86077, Pozzilli, Italy.
Maione S; Department of Experimental Medicine, Pharmacology Division, University of Campania 'L. Vanvitelli', 80138 Naples, Italy.; I.R.C.S.S., Neuromed, 86077, Pozzilli, Italy.
Guida F; Department of Experimental Medicine, Pharmacology Division, University of Campania 'L. Vanvitelli', 80138 Naples, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 02; Vol. 22 (3). Date of Electronic Publication: 2021 Feb 02.
Typ publikacji :
Journal Article
MeSH Terms :
Analgesics/*therapeutic use
Anti-Inflammatory Agents/*therapeutic use
Glycolipids/*therapeutic use
Hyperalgesia/*prevention & control
Keratitis/*drug therapy
Neuralgia/*drug therapy
Toll-Like Receptor 4/*antagonists & inhibitors
Analgesics/pharmacology ; Animals ; Anti-Inflammatory Agents/pharmacology ; Calcium Signaling/drug effects ; Cytokines/metabolism ; Drug Evaluation, Preclinical ; Glycolipids/pharmacology ; HEK293 Cells ; Humans ; Hyperalgesia/etiology ; Keratitis/chemically induced ; Keratitis/pathology ; Lipopolysaccharides/toxicity ; Lymphocyte Antigen 96/metabolism ; Male ; Mice ; MicroRNAs/genetics ; Models, Molecular ; Nociceptors/drug effects ; Nociceptors/physiology ; Protein Conformation ; RAW 264.7 Cells ; Random Allocation ; Sciatic Nerve/injuries ; TRPA1 Cation Channel/metabolism
Czasopismo naukowe
Tytuł :
Type I Interferons Act Directly on Nociceptors to Produce Pain Sensitization: Implications for Viral Infection-Induced Pain.
Autorzy :
Barragán-Iglesias P; School of Behavioral and Brain Sciences and Center for Advanced Pain Studies, University of Texas at Dallas, Dallas, Texas, 75080.; Department of Physiology and Pharmacology, Center for Basic Sciences, Autonomous University of Aguascalientes, Aguascalientes, Mexico, 20130.
Franco-Enzástiga Ú; Department of Pharmacobiology, Cinvestav, Neurobiology of Pain Laboratory, Mexico City, South Campus, Mexico, 14330.
Jeevakumar V; School of Behavioral and Brain Sciences and Center for Advanced Pain Studies, University of Texas at Dallas, Dallas, Texas, 75080.
Shiers S; School of Behavioral and Brain Sciences and Center for Advanced Pain Studies, University of Texas at Dallas, Dallas, Texas, 75080.
Wangzhou A; School of Behavioral and Brain Sciences and Center for Advanced Pain Studies, University of Texas at Dallas, Dallas, Texas, 75080.
Granados-Soto V; Department of Pharmacobiology, Cinvestav, Neurobiology of Pain Laboratory, Mexico City, South Campus, Mexico, 14330.
Campbell ZT; Department of Biological Sciences, University of Texas at Dallas, Dallas, Texas.
Dussor G; School of Behavioral and Brain Sciences and Center for Advanced Pain Studies, University of Texas at Dallas, Dallas, Texas, 75080.
Price TJ; School of Behavioral and Brain Sciences and Center for Advanced Pain Studies, University of Texas at Dallas, Dallas, Texas, 75080 .
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2020 Apr 29; Vol. 40 (18), pp. 3517-3532. Date of Electronic Publication: 2020 Apr 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Central Nervous System Viral Diseases/*metabolism
Interferon Type I/*toxicity
Nociceptors/*metabolism
Pain/*metabolism
Pain Threshold/*physiology
Peripheral Nervous System Diseases/*metabolism
Animals ; Cells, Cultured ; Central Nervous System Viral Diseases/chemically induced ; Central Nervous System Viral Diseases/pathology ; Female ; Ganglia, Spinal/drug effects ; Ganglia, Spinal/metabolism ; Ganglia, Spinal/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Nociceptors/drug effects ; Nociceptors/pathology ; Pain/chemically induced ; Pain/pathology ; Pain Threshold/drug effects ; Peripheral Nervous System Diseases/chemically induced ; Peripheral Nervous System Diseases/pathology
SCR Disease Name :
Neuropathy, Painful
Czasopismo naukowe
Tytuł :
Instillation of bradykinin into femoral artery elicits cardiorespiratory reflexes involving perivascular afferents in anesthetized rats.
Autorzy :
Singh SK
Mandal MB; Department of Physiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India.
Ravindran R; Department of Physiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India.
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Źródło :
Physiology international [Physiol Int] 2020 Mar; Vol. 107 (1), pp. 40-54.
Typ publikacji :
Journal Article
MeSH Terms :
Nociceptors*/drug effects
Nociceptors*/physiology
Blood Pressure/*physiology
Bradykinin/*administration & dosage
Femoral Artery/*innervation
Heart Rate/*physiology
Respiratory Rate/*physiology
Anesthesia/methods ; Animals ; Chemoreceptor Cells/physiology ; Femoral Artery/pathology ; Injections, Intra-Arterial ; Neurophysiology/methods ; Peripheral Nerves/physiology ; Rats
Czasopismo naukowe
Tytuł :
[Pain in rheumatic diseases : What can biologics and JAK inhibitors offer?]
Autorzy :
Pongratz G; Poliklink, Funktionsbereich und Hiller Forschungszentrum für Rheumatologie, Universitätsklinikum Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Deutschland. .
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Transliterated Title :
Schmerz bei rheumatischen Erkrankungen : Was haben Biologika und Januskinaseinhibitoren zu bieten?
Źródło :
Zeitschrift fur Rheumatologie [Z Rheumatol] 2021 Apr; Vol. 80 (3), pp. 214-225. Date of Electronic Publication: 2021 Jan 14.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Biological Products*/adverse effects
Janus Kinase Inhibitors*
Rheumatic Diseases*/complications
Rheumatic Diseases*/diagnosis
Rheumatic Diseases*/drug therapy
Biological Factors ; Humans ; Nociceptors
Czasopismo naukowe
Tytuł :
Interaction of pain and chronic inflammation.
Autorzy :
Seifert O; Klinik für Endokrinologie, Nephrologie und Rheumatologie, Universitätsklinikum Leipzig AöR, Liebigstr. 20, 04103, Leipzig, Germany. .
Baerwald C; Klinik für Endokrinologie, Nephrologie und Rheumatologie, Universitätsklinikum Leipzig AöR, Liebigstr. 20, 04103, Leipzig, Germany.
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Transliterated Title :
Wechselwirkungen von Schmerz und chronischer Entzündung.
Źródło :
Zeitschrift fur Rheumatologie [Z Rheumatol] 2021 Apr; Vol. 80 (3), pp. 205-213. Date of Electronic Publication: 2020 Dec 29.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Pain*
Rheumatic Diseases*
Humans ; Hyperalgesia ; Inflammation ; Nociceptors
Czasopismo naukowe
Tytuł :
Gut nociceptors: sentinels promoting host defense.
Autorzy :
Brierley SM; Visceral Pain Research Group, College of Medicine and Public Health, Flinders University, Bedford Park, SA, 5042, Australia. .; Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), North Terrace, Adelaide, SA, 5000, Australia. .; Discipline of Medicine, University of Adelaide, Adelaide, SA, 5000, Australia. .
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Źródło :
Cell research [Cell Res] 2020 Apr; Vol. 30 (4), pp. 279-280.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Gastrointestinal Microbiome*
Nociceptors*
Neurons ; Salmonella
Czasopismo naukowe

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