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Wyszukujesz frazę ""NUCLEOSOME"" wg kryterium: Temat


Tytuł:
The NuRD Complex in Neurodevelopment and Disease: A Case of Sliding Doors.
Autorzy:
Boulasiki P; UCL Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK.
Tan XW; UCL Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK.
Spinelli M; UCL Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK.; Neuroscience Department, Catholic University of the Sacred Heart, 00168 Rome, Italy.
Riccio A; UCL Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK.
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Źródło:
Cells [Cells] 2023 Apr 18; Vol. 12 (8). Date of Electronic Publication: 2023 Apr 18.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Mi-2 Nucleosome Remodeling and Deacetylase Complex*/genetics
Mi-2 Nucleosome Remodeling and Deacetylase Complex*/metabolism
Nucleosomes*
Animals ; Humans ; Chromatin ; Chromatin Assembly and Disassembly ; Mammals/metabolism
Czasopismo naukowe
Tytuł:
Fbxw7 suppresses carcinogenesis and stemness in triple-negative breast cancer through CHD4 degradation and Wnt/β-catenin pathway inhibition.
Autorzy:
Xiao G; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe Dong Road, ErQi District, Zhengzhou, 450052, Henan, China.
Lu W; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe Dong Road, ErQi District, Zhengzhou, 450052, Henan, China.
Yuan J; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe Dong Road, ErQi District, Zhengzhou, 450052, Henan, China.
Liu Z; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe Dong Road, ErQi District, Zhengzhou, 450052, Henan, China.
Wang P; Breast Cancer Center, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, No 127 Dongming Road, Jinshui District, Zhengzhou, 450008, Henan, China.
Fan H; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe Dong Road, ErQi District, Zhengzhou, 450052, Henan, China. .
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Źródło:
Journal of translational medicine [J Transl Med] 2024 Jan 24; Vol. 22 (1), pp. 99. Date of Electronic Publication: 2024 Jan 24.
Typ publikacji:
Journal Article
MeSH Terms:
Triple Negative Breast Neoplasms*/genetics
Animals ; Humans ; beta Catenin ; Carcinogenesis ; Cell Transformation, Neoplastic ; F-Box-WD Repeat-Containing Protein 7/genetics ; Mi-2 Nucleosome Remodeling and Deacetylase Complex
Czasopismo naukowe
Tytuł:
Disintegration of the NuRD Complex in Primary Human Muscle Stem Cells in Critical Illness Myopathy.
Autorzy:
Schneider J; Muscle Research Unit, Experimental and Clinical Research Center, A Joint Cooperation of the Charité Universitätsmedizin Berlin and the Max Delbrück Center for Molecular Medicine in the Helmholtz Society, Lindenberger Weg 80, 13125 Berlin, Germany.; Charité Universitätsmedizin Berlin, Department of Pediatric Neurology, 13353 Berlin, Germany.; Berlin Institute of Health-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Sundaravinayagam D; Laboratory of DNA Repair and Maintenance of Genome Stability, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, 13092 Berlin, Germany.
Blume A; Berlin Institute of Medical Systems Biology (BIMSB), Max Delbruck Center for Molecular Medicine in the Helmholtz Association, 10115 Berlin, Germany.
Marg A; Muscle Research Unit, Experimental and Clinical Research Center, A Joint Cooperation of the Charité Universitätsmedizin Berlin and the Max Delbrück Center for Molecular Medicine in the Helmholtz Society, Lindenberger Weg 80, 13125 Berlin, Germany.
Grunwald S; Muscle Research Unit, Experimental and Clinical Research Center, A Joint Cooperation of the Charité Universitätsmedizin Berlin and the Max Delbrück Center for Molecular Medicine in the Helmholtz Society, Lindenberger Weg 80, 13125 Berlin, Germany.
Metzler E; Muscle Research Unit, Experimental and Clinical Research Center, A Joint Cooperation of the Charité Universitätsmedizin Berlin and the Max Delbrück Center for Molecular Medicine in the Helmholtz Society, Lindenberger Weg 80, 13125 Berlin, Germany.
Escobar H; Muscle Research Unit, Experimental and Clinical Research Center, A Joint Cooperation of the Charité Universitätsmedizin Berlin and the Max Delbrück Center for Molecular Medicine in the Helmholtz Society, Lindenberger Weg 80, 13125 Berlin, Germany.
Müthel S; Muscle Research Unit, Experimental and Clinical Research Center, A Joint Cooperation of the Charité Universitätsmedizin Berlin and the Max Delbrück Center for Molecular Medicine in the Helmholtz Society, Lindenberger Weg 80, 13125 Berlin, Germany.; Berlin Institute of Medical Systems Biology (BIMSB), Max Delbruck Center for Molecular Medicine in the Helmholtz Association, 10115 Berlin, Germany.
Wang H; Muscle Research Unit, Experimental and Clinical Research Center, A Joint Cooperation of the Charité Universitätsmedizin Berlin and the Max Delbrück Center for Molecular Medicine in the Helmholtz Society, Lindenberger Weg 80, 13125 Berlin, Germany.
Wollersheim T; Berlin Institute of Health-Universitätsmedizin Berlin, 10117 Berlin, Germany.; Charité Universitätsmedizin Berlin, Department of Anesthesiology and Operative Intensive Care Medicine, 13353 Berlin, Germany.
Weber-Carstens S; Charité Universitätsmedizin Berlin, Department of Anesthesiology and Operative Intensive Care Medicine, 13353 Berlin, Germany.
Akalin A; Berlin Institute of Medical Systems Biology (BIMSB), Max Delbruck Center for Molecular Medicine in the Helmholtz Association, 10115 Berlin, Germany.
Di Virgilio M; Laboratory of DNA Repair and Maintenance of Genome Stability, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, 13092 Berlin, Germany.
Tursun B; Berlin Institute of Medical Systems Biology (BIMSB), Max Delbruck Center for Molecular Medicine in the Helmholtz Association, 10115 Berlin, Germany.
Spuler S; Muscle Research Unit, Experimental and Clinical Research Center, A Joint Cooperation of the Charité Universitätsmedizin Berlin and the Max Delbrück Center for Molecular Medicine in the Helmholtz Society, Lindenberger Weg 80, 13125 Berlin, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Feb 01; Vol. 24 (3). Date of Electronic Publication: 2023 Feb 01.
Typ publikacji:
Journal Article
MeSH Terms:
Mi-2 Nucleosome Remodeling and Deacetylase Complex*/metabolism
Muscular Diseases*/metabolism
Humans ; Animals ; Mice ; Critical Illness ; Quality of Life ; Muscle, Skeletal/metabolism ; Stem Cells
Czasopismo naukowe
Tytuł:
The epigenetic factor CHD4 contributes to metastasis by regulating the EZH2/β-catenin axis and acts as a therapeutic target in ovarian cancer.
Autorzy:
Wang J; Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200090, China.; Shanghai Key Laboratory of Female Reproductive Endocrine-Related Disease, Fudan University, Shanghai, 200090, China.
Zhong F; Department of Pathology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200090, China.
Li J; Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200090, China.
Yue H; Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200090, China.
Li W; Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200090, China.; Shanghai Key Laboratory of Female Reproductive Endocrine-Related Disease, Fudan University, Shanghai, 200090, China.
Lu X; Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200090, China. .; Shanghai Key Laboratory of Female Reproductive Endocrine-Related Disease, Fudan University, Shanghai, 200090, China. .
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Źródło:
Journal of translational medicine [J Transl Med] 2023 Jan 21; Vol. 21 (1), pp. 38. Date of Electronic Publication: 2023 Jan 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mi-2 Nucleosome Remodeling and Deacetylase Complex*/genetics
Ovarian Neoplasms*/drug therapy
Ovarian Neoplasms*/genetics
Humans ; Female ; Animals ; Mice ; beta Catenin ; Epigenesis, Genetic ; Cell Line, Tumor ; Enhancer of Zeste Homolog 2 Protein/genetics
Czasopismo naukowe
Tytuł:
Interplay between the Chd4/NuRD Complex and the Transcription Factor Znf219 Controls Cardiac Cell Identity.
Autorzy:
El Abdellaoui-Soussi F; Institute for Rare Diseases Research, Instituto de Salud Carlos III (ISCIII), 28222 Madrid, Spain.; Gene Regulation in Cardiovascular Remodelling and Inflammation Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), 28029 Madrid, Spain.
Yunes-Leites PS; Gene Regulation in Cardiovascular Remodelling and Inflammation Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), 28029 Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), 28029 Madrid, Spain.
López-Maderuelo D; Gene Regulation in Cardiovascular Remodelling and Inflammation Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), 28029 Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), 28029 Madrid, Spain.
García-Marqués F; Cardiovascular Proteomics Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), 28029 Madrid, Spain.
Vázquez J; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), 28029 Madrid, Spain.; Cardiovascular Proteomics Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), 28029 Madrid, Spain.
Redondo JM; Gene Regulation in Cardiovascular Remodelling and Inflammation Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), 28029 Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), 28029 Madrid, Spain.
Gómez-Del Arco P; Institute for Rare Diseases Research, Instituto de Salud Carlos III (ISCIII), 28222 Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), 28029 Madrid, Spain.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Aug 24; Vol. 23 (17). Date of Electronic Publication: 2022 Aug 24.
Typ publikacji:
Journal Article
MeSH Terms:
Mi-2 Nucleosome Remodeling and Deacetylase Complex*/metabolism
Transcription Factors*/genetics
Transcription Factors*/metabolism
DNA Helicases/*metabolism
DNA-Binding Proteins/*metabolism
Myocytes, Cardiac/*cytology
Myocytes, Cardiac/*metabolism
Animals ; Gene Expression Regulation ; Mice ; Muscle Proteins/genetics ; Muscle Proteins/metabolism ; Nucleosomes
Czasopismo naukowe
Tytuł:
Mouse Chd4-NURD is required for neonatal spermatogonia survival and normal gonad development.
Autorzy:
de Castro RO; Cell Cycle and Cancer Biology Research Program, Oklahoma Medical Research Foundation, Suite B305. 825 NE 13th street, Oklahoma City, OK, 73104, USA.
Carbajal A; Cell Cycle and Cancer Biology Research Program, Oklahoma Medical Research Foundation, Suite B305. 825 NE 13th street, Oklahoma City, OK, 73104, USA.
Previato de Almeida L; Cell Cycle and Cancer Biology Research Program, Oklahoma Medical Research Foundation, Suite B305. 825 NE 13th street, Oklahoma City, OK, 73104, USA.
Goitea V; Cell Cycle and Cancer Biology Research Program, Oklahoma Medical Research Foundation, Suite B305. 825 NE 13th street, Oklahoma City, OK, 73104, USA.
Griffin CT; Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.; Department of Cell Biology, University of Oklahoma Health Science Center, Oklahoma City, OK, USA.
Pezza RJ; Cell Cycle and Cancer Biology Research Program, Oklahoma Medical Research Foundation, Suite B305. 825 NE 13th street, Oklahoma City, OK, 73104, USA. .; Department of Cell Biology, University of Oklahoma Health Science Center, Oklahoma City, OK, USA. .
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Źródło:
Epigenetics & chromatin [Epigenetics Chromatin] 2022 May 14; Vol. 15 (1), pp. 16. Date of Electronic Publication: 2022 May 14.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Mi-2 Nucleosome Remodeling and Deacetylase Complex*/genetics
Spermatogonia*
DNA Helicases/*metabolism
Animals ; Cell Differentiation ; Gonads ; Male ; Mammals ; Mice ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł:
NAP1L1 promotes tumor proliferation through HDGF/C-JUN signaling in ovarian cancer.
Autorzy:
Xiaohua Zhu; Department of Obstetrics and Gynecology, The Third Affliated Hospital, Southern Medical University, Guangzhou, 510500, Guangdong, China.; The Second School of Clinical Medicine, Zhujiang Hospital, Southern Medical University, Southern Medical University, Guangzhou, Guangdong, 510280, China.
Xie Y; Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510315, Guangdong, China.
Huang W; First People's Hospital of Zhaoqing, Zhaoqing, 2102013, Guangdong, China.
Chen Z; Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510315, Guangdong, China.
Guo S; Department of Obstetrics and Gynecology, The Third Affliated Hospital, Southern Medical University, 183 Zhongshan Dadaoxi West, Guangzhou, 510500, Guangdong, China. .
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Źródło:
BMC cancer [BMC Cancer] 2022 Mar 29; Vol. 22 (1), pp. 339. Date of Electronic Publication: 2022 Mar 29.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*/genetics
Nucleosome Assembly Protein 1*/genetics
Nucleosome Assembly Protein 1*/metabolism
Ovarian Neoplasms*/pathology
Cell Line, Tumor ; Cell Proliferation ; Female ; Genes, jun ; Humans ; Intercellular Signaling Peptides and Proteins
Czasopismo naukowe
Tytuł:
Chromodomain helicase DNA-binding 4 (CHD4) regulates early B cell identity and V(D)J recombination.
Autorzy:
Hagman JR; Department of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado, USA.; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.; Program in Molecular Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Arends T; Program in Molecular Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Laborda C; Center for Genes, Environment, and Health, National Jewish Health, Denver, Colorado, USA.
Knapp JR; Center for Genes, Environment, and Health, National Jewish Health, Denver, Colorado, USA.
Harmacek L; Center for Genes, Environment, and Health, National Jewish Health, Denver, Colorado, USA.
O'Connor BP; Department of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado, USA.; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.; Center for Genes, Environment, and Health, National Jewish Health, Denver, Colorado, USA.
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Źródło:
Immunological reviews [Immunol Rev] 2022 Jan; Vol. 305 (1), pp. 29-42. Date of Electronic Publication: 2021 Dec 20.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Mi-2 Nucleosome Remodeling and Deacetylase Complex*/genetics
Mi-2 Nucleosome Remodeling and Deacetylase Complex*/metabolism
V(D)J Recombination*
B-Lymphocytes/metabolism ; DNA ; DNA Helicases/genetics ; DNA Helicases/metabolism ; Humans
Czasopismo naukowe
Tytuł:
Identification and characterization of novel proteins associated with CHD4.
Autorzy:
Sakaguchi C; Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Ichihara K; Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Nita A; Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Katayama Y; Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Nakayama KI; Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
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Źródło:
Genes to cells : devoted to molecular & cellular mechanisms [Genes Cells] 2022 Jan; Vol. 27 (1), pp. 61-71. Date of Electronic Publication: 2021 Dec 23.
Typ publikacji:
Journal Article
MeSH Terms:
Mi-2 Nucleosome Remodeling and Deacetylase Complex*/genetics
Nucleosomes*
Animals ; DNA Helicases/genetics ; DNA-Binding Proteins/genetics ; HEK293 Cells ; Humans ; Proteins
Czasopismo naukowe
Tytuł:
Unique protein interaction networks define the chromatin remodelling module of the NuRD complex.
Autorzy:
Sharifi Tabar M; Gene and Stem Cell Therapy Program Centenary Institute, The University of Sydney, Camperdown, NSW, Australia.; Faculty of Medicine & Health, The University of Sydney, NSW, Australia.
Giardina C; Gene and Stem Cell Therapy Program Centenary Institute, The University of Sydney, Camperdown, NSW, Australia.
Feng Y; Gene and Stem Cell Therapy Program Centenary Institute, The University of Sydney, Camperdown, NSW, Australia.
Francis H; Gene and Stem Cell Therapy Program Centenary Institute, The University of Sydney, Camperdown, NSW, Australia.
Moghaddas Sani H; School of Life & Environmental Sciences, The University of Sydney, NSW, Australia.
Low JKK; School of Life & Environmental Sciences, The University of Sydney, NSW, Australia.
Mackay JP; School of Life & Environmental Sciences, The University of Sydney, NSW, Australia.
Bailey CG; Gene and Stem Cell Therapy Program Centenary Institute, The University of Sydney, Camperdown, NSW, Australia.; Faculty of Medicine & Health, The University of Sydney, NSW, Australia.; Cancer & Gene Regulation Laboratory Centenary Institute, The University of Sydney, Camperdown, NSW, Australia.
Rasko JEJ; Gene and Stem Cell Therapy Program Centenary Institute, The University of Sydney, Camperdown, NSW, Australia.; Faculty of Medicine & Health, The University of Sydney, NSW, Australia.; Cell & Molecular Therapies, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
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Źródło:
The FEBS journal [FEBS J] 2022 Jan; Vol. 289 (1), pp. 199-214. Date of Electronic Publication: 2021 Jul 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chromatin Assembly and Disassembly/*genetics
Mi-2 Nucleosome Remodeling and Deacetylase Complex/*genetics
Protein Interaction Maps/*genetics
Proteome/*genetics
DNA Helicases/genetics ; DNA-Binding Proteins/genetics ; Gene Expression Regulation ; Humans ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/ultrastructure ; Multiprotein Complexes/genetics ; Nucleosomes/genetics ; Nucleosomes/ultrastructure ; Repressor Proteins/genetics ; Tumor Suppressor Proteins/genetics
Czasopismo naukowe
Tytuł:
GFI1 tethers the NuRD complex to open and transcriptionally active chromatin in myeloid progenitors.
Autorzy:
Helness A; Institut de recherches cliniques de Montréal, Montréal, QC, H2W 1R7, Canada.
Fraszczak J; Institut de recherches cliniques de Montréal, Montréal, QC, H2W 1R7, Canada.
Joly-Beauparlant C; Département de Médecine Moléculaire, Faculté de Médecine, Université Laval, Québec, QC, Canada.
Bagci H; Institut de recherches cliniques de Montréal, Montréal, QC, H2W 1R7, Canada.; Institute for Biochemistry, ETH Zürich, Zürich, Switzerland.
Trahan C; Institut de recherches cliniques de Montréal, Montréal, QC, H2W 1R7, Canada.
Arman K; Institut de recherches cliniques de Montréal, Montréal, QC, H2W 1R7, Canada.
Shooshtarizadeh P; Institut de recherches cliniques de Montréal, Montréal, QC, H2W 1R7, Canada.
Chen R; Institut de recherches cliniques de Montréal, Montréal, QC, H2W 1R7, Canada.
Ayoub M; Institut de recherches cliniques de Montréal, Montréal, QC, H2W 1R7, Canada.; Hôpital pour Enfants, Ste Justine, Montreal, QC, Canada.
Côté JF; Institut de recherches cliniques de Montréal, Montréal, QC, H2W 1R7, Canada.; Department of Anatomy and Cell Biology, McGill University, Montréal, QC, H3A 0C7, Canada.; Département de Biochimie, Université de Montréal, Montréal, QC, H3C 3J7, Canada.; Division of Experimental Medicine, McGill University, Montreal, QC, Canada.
Oeffinger M; Institut de recherches cliniques de Montréal, Montréal, QC, H2W 1R7, Canada.; Département de Biochimie, Université de Montréal, Montréal, QC, H3C 3J7, Canada.
Droit A; Département de Médecine Moléculaire, Faculté de Médecine, Université Laval, Québec, QC, Canada.
Möröy T; Institut de recherches cliniques de Montréal, Montréal, QC, H2W 1R7, Canada. .; Division of Experimental Medicine, McGill University, Montreal, QC, Canada. .; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, QC, Canada. .
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Źródło:
Communications biology [Commun Biol] 2021 Dec 02; Vol. 4 (1), pp. 1356. Date of Electronic Publication: 2021 Dec 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Transcription, Genetic*
Chromatin/*metabolism
DNA-Binding Proteins/*genetics
Mi-2 Nucleosome Remodeling and Deacetylase Complex/*genetics
Myeloid Progenitor Cells/*metabolism
Transcription Factors/*genetics
Animals ; DNA-Binding Proteins/metabolism ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/metabolism ; Mice ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł:
Sequence and functional differences in the ATPase domains of CHD3 and SNF2H promise potential for selective regulability and drugability.
Autorzy:
Hoffmeister H; Department of Biochemistry, Genetics and Microbiology, Biochemistry III, University of Regensburg, Germany.
Fuchs A; Department of Biochemistry, Genetics and Microbiology, Biochemistry III, University of Regensburg, Germany.
Komives E; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USA.
Groebner-Ferreira R; Department of Biochemistry, Genetics and Microbiology, Biochemistry III, University of Regensburg, Germany.
Strobl L; Department of Biochemistry, Genetics and Microbiology, Biochemistry III, University of Regensburg, Germany.
Nazet J; Department of Biochemistry II, University of Regensburg, Germany.
Heizinger L; Department of Biochemistry II, University of Regensburg, Germany.
Merkl R; Department of Biochemistry II, University of Regensburg, Germany.
Dove S; Department of Pharmaceutical and Medical Chemistry II, University of Regensburg, Germany.
Längst G; Department of Biochemistry, Genetics and Microbiology, Biochemistry III, University of Regensburg, Germany.
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Źródło:
The FEBS journal [FEBS J] 2021 Jul; Vol. 288 (13), pp. 4000-4023. Date of Electronic Publication: 2021 Feb 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adenosine Triphosphatases/*metabolism
Adenosine Triphosphate/*metabolism
Chromosomal Proteins, Non-Histone/*metabolism
DNA Helicases/*metabolism
Mi-2 Nucleosome Remodeling and Deacetylase Complex/*metabolism
Adenosine Diphosphate/metabolism ; Adenosine Triphosphatases/chemistry ; Adenosine Triphosphatases/genetics ; Amino Acid Sequence ; Binding, Competitive ; Chromatin/genetics ; Chromatin/metabolism ; Chromatin Assembly and Disassembly ; Chromosomal Proteins, Non-Histone/chemistry ; Chromosomal Proteins, Non-Histone/genetics ; DNA Helicases/chemistry ; DNA Helicases/genetics ; Humans ; Hydrolysis ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/chemistry ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/genetics ; Mutation ; Nucleosomes/genetics ; Nucleosomes/metabolism ; Protein Binding ; Protein Domains ; Sequence Homology, Amino Acid ; Substrate Specificity
Czasopismo naukowe
Tytuł:
Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.
Autorzy:
Spruijt CG; Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Oncode Institute, Radboud University Nijmegen, Nijmegen, The Netherlands.
Gräwe C; Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Oncode Institute, Radboud University Nijmegen, Nijmegen, The Netherlands.
Kleinendorst SC; Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Oncode Institute, Radboud University Nijmegen, Nijmegen, The Netherlands.
Baltissen MPA; Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Oncode Institute, Radboud University Nijmegen, Nijmegen, The Netherlands.
Vermeulen M; Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Oncode Institute, Radboud University Nijmegen, Nijmegen, The Netherlands.
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Źródło:
The FEBS journal [FEBS J] 2021 May; Vol. 288 (10), pp. 3231-3245. Date of Electronic Publication: 2020 Dec 14.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Cyclin-Dependent Kinases/*chemistry
GATA Transcription Factors/*chemistry
Histone Deacetylases/*chemistry
Mi-2 Nucleosome Remodeling and Deacetylase Complex/*chemistry
Nucleosomes/*ultrastructure
Amino Acid Sequence ; Binding Sites ; Cell Line, Tumor ; Cross-Linking Reagents/chemistry ; Cyclin-Dependent Kinases/genetics ; Cyclin-Dependent Kinases/metabolism ; GATA Transcription Factors/genetics ; GATA Transcription Factors/metabolism ; HeLa Cells ; Histone Deacetylases/genetics ; Histone Deacetylases/metabolism ; Humans ; Mass Spectrometry/methods ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/genetics ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/metabolism ; Models, Molecular ; Nucleosomes/genetics ; Nucleosomes/metabolism ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Protein Interaction Mapping ; Protein Subunits/chemistry ; Protein Subunits/genetics ; Protein Subunits/metabolism ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Sequence Alignment ; Sequence Homology, Amino Acid
Czasopismo naukowe
Tytuł:
Chromatin Remodeling in the Brain-a NuRD evelopmental Odyssey.
Autorzy:
Larrigan S; Department of Cell and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; Ottawa Health Research Institute (OHRI), Ottawa, ON K1H 8L6, Canada.
Shah S; Department of Cell and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; Ottawa Health Research Institute (OHRI), Ottawa, ON K1H 8L6, Canada.
Fernandes A; Department of Cell and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; Ottawa Health Research Institute (OHRI), Ottawa, ON K1H 8L6, Canada.
Mattar P; Department of Cell and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; Ottawa Health Research Institute (OHRI), Ottawa, ON K1H 8L6, Canada.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 30; Vol. 22 (9). Date of Electronic Publication: 2021 Apr 30.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Chromatin Assembly and Disassembly*
Brain/*growth & development
Mi-2 Nucleosome Remodeling and Deacetylase Complex/*metabolism
Animals ; Brain/embryology ; Brain/metabolism ; Humans ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/genetics ; Neural Stem Cells/cytology ; Neural Stem Cells/metabolism ; Neurogenesis ; Neurons/cytology ; Neurons/metabolism
Czasopismo naukowe
Tytuł:
CHD4 Predicts Aggressiveness in PTC Patients and Promotes Cancer Stemness and EMT in PTC Cells.
Autorzy:
Pratheeshkumar P; Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, P.O. Box 3354, Riyadh 11211, Saudi Arabia.
Siraj AK; Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, P.O. Box 3354, Riyadh 11211, Saudi Arabia.
Divya SP; Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, P.O. Box 3354, Riyadh 11211, Saudi Arabia.
Parvathareddy SK; Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, P.O. Box 3354, Riyadh 11211, Saudi Arabia.
Alobaisi K; Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, P.O. Box 3354, Riyadh 11211, Saudi Arabia.
Al-Sobhi SS; Department of Surgery, King Faisal Specialist Hospital and Research Center, P.O. Box 3354, Riyadh 11211, Saudi Arabia.
Al-Dayel F; Department of Pathology, King Faisal Specialist Hospital and Research Center, P.O. Box 3354, Riyadh 11211, Saudi Arabia.
Al-Kuraya KS; Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, P.O. Box 3354, Riyadh 11211, Saudi Arabia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Jan 06; Vol. 22 (2). Date of Electronic Publication: 2021 Jan 06.
Typ publikacji:
Journal Article
MeSH Terms:
Gene Expression Regulation, Neoplastic*
Epithelial-Mesenchymal Transition/*genetics
Mi-2 Nucleosome Remodeling and Deacetylase Complex/*genetics
Neoplastic Stem Cells/*metabolism
Thyroid Cancer, Papillary/*genetics
Thyroid Neoplasms/*genetics
Adult ; Cadherins/genetics ; Cadherins/metabolism ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Cohort Studies ; Female ; Humans ; Kaplan-Meier Estimate ; Male ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/metabolism ; Middle Aged ; Prognosis ; Thyroid Cancer, Papillary/metabolism ; Thyroid Cancer, Papillary/pathology ; Thyroid Neoplasms/metabolism ; Thyroid Neoplasms/pathology
Czasopismo naukowe
Tytuł:
CHD4 orchestrates the symphony of T and B lymphocytes development and a good mediator in preventing from autoimmune disease.
Autorzy:
Jia M; Reproductive Sciences Institute, Jiangsu University, Zhenjiang, Jiangsu, P.R. China.; Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, P.R. China.
Zou X; Reproductive Sciences Institute, Jiangsu University, Zhenjiang, Jiangsu, P.R. China.; Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, P.R. China.
Yin S; Reproductive Sciences Institute, Jiangsu University, Zhenjiang, Jiangsu, P.R. China.; Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, P.R. China.
Tian W; Reproductive Sciences Institute, Jiangsu University, Zhenjiang, Jiangsu, P.R. China.; Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, P.R. China.
Zhao Y; Reproductive Sciences Institute, Jiangsu University, Zhenjiang, Jiangsu, P.R. China.; Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, P.R. China.
Wang H; Reproductive Sciences Institute, Jiangsu University, Zhenjiang, Jiangsu, P.R. China.; Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, P.R. China.
Xu G; School of Medical Science and Laboratory Medicine, Institute of Medical Genetics and Reproductive Immunity, Jiangsu College of Nursing, Huai'an, Jiangsu, P.R. China.
Cai W; School of Medical Science and Laboratory Medicine, Institute of Medical Genetics and Reproductive Immunity, Jiangsu College of Nursing, Huai'an, Jiangsu, P.R. China.
Shao Q; Reproductive Sciences Institute, Jiangsu University, Zhenjiang, Jiangsu, P.R. China.; Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, P.R. China.; School of Medical Science and Laboratory Medicine, Institute of Medical Genetics and Reproductive Immunity, Jiangsu College of Nursing, Huai'an, Jiangsu, P.R. China.
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Źródło:
Immunity, inflammation and disease [Immun Inflamm Dis] 2022 Jul; Vol. 10 (7), pp. e644.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Autoimmune Diseases*
Chromatin Assembly and Disassembly*
B-Lymphocytes/metabolism ; Cell Differentiation ; Humans ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/genetics ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/metabolism ; Nucleosomes ; T-Lymphocytes
Czasopismo naukowe
Tytuł:
The stoichiometry and interactome of the Nucleosome Remodeling and Deacetylase (NuRD) complex are conserved across multiple cell lines.
Autorzy:
Sharifi Tabar M; School of Life and Environmental Sciences, University of Sydney, Australia.
Mackay JP; School of Life and Environmental Sciences, University of Sydney, Australia.
Low JKK; School of Life and Environmental Sciences, University of Sydney, Australia.
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Źródło:
The FEBS journal [FEBS J] 2019 Jun; Vol. 286 (11), pp. 2043-2061. Date of Electronic Publication: 2019 Mar 19.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Interaction Maps*
Cell Line, Tumor/*chemistry
Mi-2 Nucleosome Remodeling and Deacetylase Complex/*metabolism
Neoplasm Proteins/*metabolism
Adenine Nucleotide Translocator 2/metabolism ; Centrifugation, Density Gradient ; Chromatography, Affinity ; Chromatography, Liquid ; DNA-Binding Proteins/metabolism ; Gene Expression Profiling ; Humans ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/chemistry ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/genetics ; Neoplasm Proteins/chemistry ; Neoplasm Proteins/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; Protein Interaction Mapping/methods ; Protein Subunits ; RNA, Messenger/biosynthesis ; RNA, Neoplasm/biosynthesis ; Recombinant Proteins/metabolism ; Tandem Mass Spectrometry ; Zinc Fingers
Czasopismo naukowe
Tytuł:
A New Role of NAP1L1 in Megakaryocytes and Human Platelets.
Autorzy:
Freitag M; Department of Cardiac Surgery, Heart Center Leipzig-University Hospital, 04289 Leipzig, Germany.
Schwertz H; Molecular Medicine Program, University of Utah, Salt Lake City, UT 84112, USA.; Division of Occupational Medicine, University of Utah, Salt Lake City, UT 84112, USA.; Occupational Medicine at Billings Clinic Bozeman, Bozeman, MT 59715, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Nov 24; Vol. 23 (23). Date of Electronic Publication: 2022 Nov 24.
Typ publikacji:
Journal Article
MeSH Terms:
Nuclear Proteins*/metabolism
Megakaryocytes*/metabolism
Humans ; Blood Platelets/metabolism ; Thrombopoiesis ; Antigens, CD34/metabolism ; Nucleosome Assembly Protein 1/metabolism
Czasopismo naukowe
Tytuł:
ARID1A-dependent maintenance of H3.3 is required for repressive CHD4-ZMYND8 chromatin interactions at super-enhancers.
Autorzy:
Reske JJ; Department of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI, 49503, USA.
Wilson MR; Department of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI, 49503, USA.
Armistead B; Department of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI, 49503, USA.
Harkins S; Department of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI, 49503, USA.
Perez C; Department of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI, 49503, USA.
Hrit J; Department of Epigenetics, Van Andel Research Institute, Grand Rapids, MI, 49503, USA.
Adams M; Genomics Core Facility, Van Andel Research Institute, Grand Rapids, MI, 49503, USA.
Rothbart SB; Department of Epigenetics, Van Andel Research Institute, Grand Rapids, MI, 49503, USA.
Missmer SA; Department of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI, 49503, USA.; Department of Women's Health, Spectrum Health System, Grand Rapids, MI, 49341, USA.
Fazleabas AT; Department of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI, 49503, USA.; Department of Women's Health, Spectrum Health System, Grand Rapids, MI, 49341, USA.
Chandler RL; Department of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI, 49503, USA. .; Department of Epigenetics, Van Andel Research Institute, Grand Rapids, MI, 49503, USA. .; Department of Women's Health, Spectrum Health System, Grand Rapids, MI, 49341, USA. .
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Źródło:
BMC biology [BMC Biol] 2022 Sep 25; Vol. 20 (1), pp. 209. Date of Electronic Publication: 2022 Sep 25.
Typ publikacji:
Journal Article
MeSH Terms:
Chromatin*/genetics
DNA-Binding Proteins*/genetics
DNA-Binding Proteins*/metabolism
Histones*/genetics
Transcription Factors*/genetics
Transcription Factors*/metabolism
Chromatin Assembly and Disassembly ; DNA ; Female ; Humans ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/genetics ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/metabolism ; Nucleosomes
Czasopismo naukowe

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