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Wyświetlanie 1-7 z 7
Tytuł :
Novel mouse model for evaluating in vivo efficacy of xCT inhibitor.
Autorzy :
Yoshioka R; Asubio Pharma Co., Ltd., 6-4-3, Minatojima-minamimachi, Chuou-ku, Kobe, Japan. Electronic address: .
Fujieda Y; Asubio Pharma Co., Ltd., 6-4-3, Minatojima-minamimachi, Chuou-ku, Kobe, Japan. Electronic address: .
Suzuki Y; Asubio Pharma Co., Ltd., 6-4-3, Minatojima-minamimachi, Chuou-ku, Kobe, Japan. Electronic address: .
Kanno O; Asubio Pharma Co., Ltd., 6-4-3, Minatojima-minamimachi, Chuou-ku, Kobe, Japan. Electronic address: .
Nagahira A; Asubio Pharma Co., Ltd., 6-4-3, Minatojima-minamimachi, Chuou-ku, Kobe, Japan. Electronic address: nagahira.asako..
Honda T; Asubio Pharma Co., Ltd., 6-4-3, Minatojima-minamimachi, Chuou-ku, Kobe, Japan. Electronic address: .
Murakawa M; Asubio Pharma Co., Ltd., 6-4-3, Minatojima-minamimachi, Chuou-ku, Kobe, Japan. Electronic address: .
Yukiura H; Asubio Pharma Co., Ltd., 6-4-3, Minatojima-minamimachi, Chuou-ku, Kobe, Japan. Electronic address: .
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Źródło :
Journal of pharmacological sciences [J Pharmacol Sci] 2019 Jul; Vol. 140 (3), pp. 242-247. Date of Electronic Publication: 2019 Aug 03.
Typ publikacji :
Journal Article
MeSH Terms :
Alkynes/*pharmacology
Amino Acid Transport System y+/*antagonists & inhibitors
Glycine/*analogs & derivatives
Animals ; Cystathionine/metabolism ; Female ; Glycine/pharmacology ; Mice ; Mice, Inbred C57BL ; Models, Animal ; Piperazines/pharmacology ; Spleen/drug effects ; Spleen/metabolism ; Tandem Mass Spectrometry/methods ; Thymus Gland/drug effects ; Thymus Gland/metabolism
Czasopismo naukowe
Tytuł :
Small-molecule inhibition of PTPRZ reduces tumor growth in a rat model of glioblastoma.
Autorzy :
Fujikawa A; Division of Molecular Neurobiology, National Institute for Basic Biology (NIBB), 5-1 Higashiyama, Myodaiji-cho, Okazaki, Aichi, 444-8787, Japan.
Nagahira A; Asubio Pharma Co., Ltd., 6-4-3 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.
Sugawara H; Asubio Pharma Co., Ltd., 6-4-3 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.
Ishii K; Department of Bioorganization Research, Okazaki Institute for Integrative Bioscience, 5-1 Higashiyama, Myodaiji-cho, Okazaki, Aichi, 444-8787, Japan.
Imajo S; Asubio Pharma Co., Ltd., 6-4-3 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.
Matsumoto M; Division of Molecular Neurobiology, National Institute for Basic Biology (NIBB), 5-1 Higashiyama, Myodaiji-cho, Okazaki, Aichi, 444-8787, Japan.
Kuboyama K; Division of Molecular Neurobiology, National Institute for Basic Biology (NIBB), 5-1 Higashiyama, Myodaiji-cho, Okazaki, Aichi, 444-8787, Japan.
Suzuki R; Division of Molecular Neurobiology, National Institute for Basic Biology (NIBB), 5-1 Higashiyama, Myodaiji-cho, Okazaki, Aichi, 444-8787, Japan.
Tanga N; Division of Molecular Neurobiology, National Institute for Basic Biology (NIBB), 5-1 Higashiyama, Myodaiji-cho, Okazaki, Aichi, 444-8787, Japan.; School of Life Science, The Graduate University for Advanced Studies (SOKENDAI), 5-1 Higashiyama, Myodaiji-cho, Okazaki, Aichi, 444-8787, Japan.
Noda M; Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Uchiyama S; Department of Bioorganization Research, Okazaki Institute for Integrative Bioscience, 5-1 Higashiyama, Myodaiji-cho, Okazaki, Aichi, 444-8787, Japan.; Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Tomoo T; Asubio Pharma Co., Ltd., 6-4-3 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.
Ogata A; Asubio Pharma Co., Ltd., 6-4-3 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.
Masumura M; Asubio Pharma Co., Ltd., 6-4-3 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.
Noda M; Division of Molecular Neurobiology, National Institute for Basic Biology (NIBB), 5-1 Higashiyama, Myodaiji-cho, Okazaki, Aichi, 444-8787, Japan.; School of Life Science, The Graduate University for Advanced Studies (SOKENDAI), 5-1 Higashiyama, Myodaiji-cho, Okazaki, Aichi, 444-8787, Japan.
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Źródło :
Scientific reports [Sci Rep] 2016 Feb 09; Vol. 6, pp. 20473. Date of Electronic Publication: 2016 Feb 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Enzyme Inhibitors*/chemistry
Enzyme Inhibitors*/pharmacology
Glioblastoma*/drug therapy
Glioblastoma*/enzymology
Glioblastoma*/genetics
Molecular Docking Simulation*
Neoplasm Proteins*/antagonists & inhibitors
Neoplasm Proteins*/chemistry
Neoplasm Proteins*/genetics
Neoplasm Proteins*/metabolism
Neoplasms, Experimental*/drug therapy
Neoplasms, Experimental*/enzymology
Neoplasms, Experimental*/genetics
Receptor-Like Protein Tyrosine Phosphatases, Class 5*/antagonists & inhibitors
Receptor-Like Protein Tyrosine Phosphatases, Class 5*/chemistry
Receptor-Like Protein Tyrosine Phosphatases, Class 5*/genetics
Receptor-Like Protein Tyrosine Phosphatases, Class 5*/metabolism
Animals ; Cell Line, Tumor ; Crystallography, X-Ray ; Male ; Mutagenesis, Site-Directed ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Quantitative analysis of cadherin-11 and β-catenin signalling during proliferation of rheumatoid arthritis-derived synovial fibroblast cells.
Autorzy :
Yoshioka R; Faculty of Exploratory Pharmacology, Asubio Pharma Co., Ltd., Kobe, Japan.
Kita Y; Faculty of Exploratory Pharmacology, Asubio Pharma Co., Ltd., Kobe, Japan.
Nagahira A; Faculty of Drug Discovery Technology, Asubio Pharma Co., Ltd., Kobe, Japan.
Manno A; Faculty of Exploratory Pharmacology, Asubio Pharma Co., Ltd., Kobe, Japan.
Makita N; Faculty of Exploratory Pharmacology, Asubio Pharma Co., Ltd., Kobe, Japan.
Tomita U; Faculty of Exploratory Pharmacology, Asubio Pharma Co., Ltd., Kobe, Japan.
Murakawa M; Faculty of Exploratory Pharmacology, Asubio Pharma Co., Ltd., Kobe, Japan.
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Źródło :
The Journal of pharmacy and pharmacology [J Pharm Pharmacol] 2015 Aug; Vol. 67 (8), pp. 1075-82. Date of Electronic Publication: 2015 Mar 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Arthritis, Rheumatoid/*physiopathology
Cadherins/*pharmacology
Fibroblasts/*metabolism
Interleukin-1beta/*pharmacology
Tumor Necrosis Factor-alpha/*pharmacology
beta Catenin/*pharmacology
Cell Proliferation/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Male ; RNA, Small Interfering/metabolism ; Signal Transduction ; Synovial Membrane/physiopathology
Czasopismo naukowe
Tytuł :
Orally active ghrelin receptor inverse agonists and their actions on a rat obesity model.
Autorzy :
Takahashi B; Asubio Pharma Co., Ltd, 6-4-3, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan. Electronic address: .
Funami H; Asubio Pharma Co., Ltd, 6-4-3, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan.
Iwaki T; Asubio Pharma Co., Ltd, 6-4-3, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan.
Maruoka H; Asubio Pharma Co., Ltd, 6-4-3, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan.
Shibata M; Asubio Pharma Co., Ltd, 6-4-3, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan.
Koyama M; Asubio Pharma Co., Ltd, 6-4-3, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan.
Nagahira A; Asubio Pharma Co., Ltd, 6-4-3, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan.
Kamiide Y; Asubio Pharma Co., Ltd, 6-4-3, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan.
Kanki S; Asubio Pharma Co., Ltd, 6-4-3, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan.
Igawa Y; Asubio Pharma Co., Ltd, 6-4-3, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan.
Muto T; Asubio Pharma Co., Ltd, 6-4-3, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan.
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Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2015 Aug 01; Vol. 23 (15), pp. 4792-4803. Date of Electronic Publication: 2015 Jun 09.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Obesity Agents/*chemistry
Receptors, Ghrelin/*agonists
Administration, Oral ; Animals ; Anti-Obesity Agents/administration & dosage ; Anti-Obesity Agents/pharmacokinetics ; Disease Models, Animal ; Drug Inverse Agonism ; Half-Life ; Humans ; Male ; Mice ; Mice, Inbred ICR ; Microsomes, Liver/metabolism ; Niacinamide/administration & dosage ; Niacinamide/chemistry ; Niacinamide/pharmacokinetics ; Obesity/drug therapy ; Obesity/pathology ; Rats ; Rats, Sprague-Dawley ; Receptors, Ghrelin/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
2-Aminoalkyl nicotinamide derivatives as pure inverse agonists of the ghrelin receptor.
Autorzy :
Takahashi B; Asubio Pharma Co., Ltd, 6-4-3 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan. Electronic address: .
Funami H; Asubio Pharma Co., Ltd, 6-4-3 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan.
Iwaki T; Asubio Pharma Co., Ltd, 6-4-3 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan.
Maruoka H; Asubio Pharma Co., Ltd, 6-4-3 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan.
Nagahira A; Asubio Pharma Co., Ltd, 6-4-3 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan.
Koyama M; Asubio Pharma Co., Ltd, 6-4-3 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan.
Kamiide Y; Asubio Pharma Co., Ltd, 6-4-3 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan.
Matsuo T; Asubio Pharma Co., Ltd, 6-4-3 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan.
Muto T; Asubio Pharma Co., Ltd, 6-4-3 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan.
Annoura H; Asubio Pharma Co., Ltd, 6-4-3 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan.
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2015 Jul 01; Vol. 25 (13), pp. 2707-12. Date of Electronic Publication: 2015 May 01.
Typ publikacji :
Journal Article
MeSH Terms :
Niacinamide/*analogs & derivatives
Receptors, Ghrelin/*agonists
Receptors, Ghrelin/*antagonists & inhibitors
Animals ; Anti-Obesity Agents/chemical synthesis ; Anti-Obesity Agents/chemistry ; Anti-Obesity Agents/pharmacology ; Appetite Regulation/drug effects ; Drug Design ; HEK293 Cells ; High-Throughput Screening Assays ; Humans ; Mice ; Niacinamide/chemistry ; Niacinamide/pharmacology ; Obesity/drug therapy ; Obesity/physiopathology ; Rats ; Structure-Activity Relationship
Czasopismo naukowe
    Wyświetlanie 1-7 z 7

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