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Wyszukujesz frazę ""Naphthalenes"" wg kryterium: Temat


Tytuł :
5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma.
Autorzy :
Wang S; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China.
Yang H; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China.
Su M; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Qixia District, Nanjing, 210023, China.
Lian F; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China.
Cong Z; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China.
Wei R; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China.
Zhou Y; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China; Zhongshan Institute of Drug Discovery, Institution for Drug Discovery Innovation, Chinese Academy of Science, Zhongshan, 528400, China.
Li X; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China.
Zheng X; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China.
Li C; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, UCAS, Hangzhou, 310024, China.
Fu X; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China.
Han X; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China.
Shi Q; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China.
Li C; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China.
Zhang N; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China.
Geng M; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China.
Liu H; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Qixia District, Nanjing, 210023, China; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, UCAS, Hangzhou, 310024, China.
Li J; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Qixia District, Nanjing, 210023, China; Zhongshan Institute of Drug Discovery, Institution for Drug Discovery Innovation, Chinese Academy of Science, Zhongshan, 528400, China; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, UCAS, Hangzhou, 310024, China. Electronic address: .
Huang X; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, UCAS, Hangzhou, 310024, China. Electronic address: .
Wang J; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, UCAS, Hangzhou, 310024, China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Oct 15; Vol. 222, pp. 113592. Date of Electronic Publication: 2021 Jun 05.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Enzyme Inhibitors/*pharmacology
Histone-Lysine N-Methyltransferase/*antagonists & inhibitors
Multiple Myeloma/*drug therapy
Naphthalenes/*pharmacology
Repressor Proteins/*antagonists & inhibitors
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Cell Cycle Checkpoints/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Histone-Lysine N-Methyltransferase/metabolism ; Humans ; Molecular Structure ; Multiple Myeloma/metabolism ; Multiple Myeloma/pathology ; Naphthalenes/chemical synthesis ; Naphthalenes/chemistry ; Repressor Proteins/metabolism ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Structure-based molecular hybridization design of Keap1-Nrf2 inhibitors as novel protective agents of acute lung injury.
Autorzy :
Zhang L; School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan, 750004, China; School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai, 200433, China.
Xu L; School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan, 750004, China; School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai, 200433, China.
Chen H; Department of Intervention, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
Zhang W; School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan, 750004, China; School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai, 200433, China.
Xing C; Department of Medicinal Chemistry, University of Florida, 1345 Center Drive, Gainesville, FL, 32610, USA.
Qu Z; School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai, 200433, China. Electronic address: .
Yu J; School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan, 750004, China. Electronic address: .
Zhuang C; School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan, 750004, China; School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai, 200433, China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Oct 15; Vol. 222, pp. 113599. Date of Electronic Publication: 2021 Jun 05.
Typ publikacji :
Journal Article
MeSH Terms :
Acute Lung Injury/*drug therapy
Kelch-Like ECH-Associated Protein 1/*antagonists & inhibitors
NF-E2-Related Factor 2/*antagonists & inhibitors
Naphthalenes/*pharmacology
Protective Agents/*pharmacology
Sulfonamides/*pharmacology
Acute Lung Injury/metabolism ; Animals ; Dose-Response Relationship, Drug ; Drug Design ; Female ; Kelch-Like ECH-Associated Protein 1/metabolism ; Mice ; Mice, Inbred C57BL ; Molecular Structure ; NF-E2-Related Factor 2/metabolism ; Naphthalenes/chemical synthesis ; Naphthalenes/chemistry ; Protective Agents/chemical synthesis ; Protective Agents/chemistry ; Structure-Activity Relationship ; Sulfonamides/chemical synthesis ; Sulfonamides/chemistry
Czasopismo naukowe
Tytuł :
DNA Binding Mode Analysis of a Core-Extended Naphthalene Diimide as a Conformation-Sensitive Fluorescent Probe of G-Quadruplex Structures.
Autorzy :
Platella C; Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.
Gaglione R; Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.; Istituto Nazionale di Biostrutture e Biosistemi (INBB), 00136 Rome, Italy.
Napolitano E; Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.
Arciello A; Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.; Istituto Nazionale di Biostrutture e Biosistemi (INBB), 00136 Rome, Italy.
Pirota V; Department of Chemistry, University of Pavia, 27100 Pavia, Italy.
Doria F; Department of Chemistry, University of Pavia, 27100 Pavia, Italy.
Musumeci D; Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.; Institute of Biostructures and Bioimaging (IBB) of the National Research Council (CNR), 80145 Naples, Italy.
Montesarchio D; Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 30; Vol. 22 (19). Date of Electronic Publication: 2021 Sep 30.
Typ publikacji :
Journal Article
MeSH Terms :
G-Quadruplexes*
Molecular Conformation*
Adenocarcinoma/*metabolism
Breast Neoplasms/*metabolism
DNA, B-Form/*metabolism
Fluorescent Dyes/*chemistry
Fluorescent Dyes/*metabolism
Imides/*chemistry
Imides/*metabolism
Intercalating Agents/*chemistry
Intercalating Agents/*metabolism
Naphthalenes/*chemistry
Naphthalenes/*metabolism
Adenocarcinoma/pathology ; Binding Sites ; Breast Neoplasms/pathology ; Cell Survival/drug effects ; Female ; Fluorescent Dyes/pharmacology ; Humans ; Imides/pharmacology ; Inhibitory Concentration 50 ; Intercalating Agents/pharmacology ; Ligands ; MCF-7 Cells ; Magnetic Resonance Spectroscopy/methods ; Molecular Docking Simulation/methods ; Naphthalenes/pharmacology
Czasopismo naukowe
Tytuł :
Tinea capitis asymptomatic carriers: what is the evidence behind treatment?
Autorzy :
Aharaz A; Department of Dermatology, Zealand University Hospital, Roskilde, Denmark.
Jemec GBE; Department of Dermatology, Zealand University Hospital, Roskilde, Denmark.; Department of Clinical Medicine, Faculty of Health Sciences, University of Copenhagen, Denmark.
Hay RJ; St John's Institute of Dermatology, Kings College London, London, UK.
Saunte DML; Department of Dermatology, Zealand University Hospital, Roskilde, Denmark.; Department of Clinical Medicine, Faculty of Health Sciences, University of Copenhagen, Denmark.
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Źródło :
Journal of the European Academy of Dermatology and Venereology : JEADV [J Eur Acad Dermatol Venereol] 2021 Nov; Vol. 35 (11), pp. 2199-2207. Date of Electronic Publication: 2021 Jul 24.
Typ publikacji :
Journal Article; Review; Systematic Review
MeSH Terms :
Naphthalenes*
Tinea Capitis*/drug therapy
Tinea Capitis*/epidemiology
Antifungal Agents/therapeutic use ; Child ; Humans ; Itraconazole ; Terbinafine
Czasopismo naukowe
Tytuł :
An Adjustable Cleft Based on an 8-Sulfonamide-2-Naphthoic Acid with Oxyanion Hole Geometry.
Autorzy :
Garrido-González JJ; Departamento de Química Orgánica, Universidad de Salamanca, Plaza de los Caídos s/n, Salamanca, 37008, Spain.
Boya Del Teso I; Departamento de Química Orgánica, Universidad de Salamanca, Plaza de los Caídos s/n, Salamanca, 37008, Spain.
Fuentes de Arriba ÁL; Departamento de Química Orgánica, Universidad de Salamanca, Plaza de los Caídos s/n, Salamanca, 37008, Spain.
Sanz F; Servicio de Difracción de Rayos X, University of Salamanca, Plaza de los Caídos s/n, Salamanca, 37008, Spain.
Martín Del Valle EM; Departamento de Ingeniería Química, Universidad de Salamanca, Plaza de los Caídos s/n, Salamanca, 37008, Spain.
Morán JR; Departamento de Química Orgánica, Universidad de Salamanca, Plaza de los Caídos s/n, Salamanca, 37008, Spain.
Alcázar V; Departamento de Ingeniería Química Industrial y del Medio Ambiente, Universidad Politécnica de Madrid, C/José Gutiérrez Abascal, 2, Madrid, 28006, Spain.
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Źródło :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2021 Oct 21; Vol. 27 (59), pp. 14605-14609. Date of Electronic Publication: 2021 Sep 27.
Typ publikacji :
Journal Article
MeSH Terms :
Naphthalenes*
Sulfonamides*
Hydrogen Bonding
Czasopismo naukowe
Tytuł :
Molecular Basis for Two Stereoselective Diels-Alderases that Produce Decalin Skeletons*.
Autorzy :
Fujiyama K; Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, 4-101 Koyama-cho, Minami, Tottori, 680-8552, Japan.; Current address: Dormancy and Adaptation Research Unit, RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro, Tsurumi, Yokohama, Kanagawa, 230-0045, Japan.
Kato N; Natural Product Biosynthesis Research Unit, RIKEN Center for Sustainable Research Science, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan.; Faculty of Agriculture, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan.
Re S; Laboratory for Biomolecular Function Simulation, RIKEN Center for Biosystems Dynamics Research, 2-2-3 Minatojima-minami-machi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.; Artificial Intelligence Center for Health and Biomedical Research, National Institutes of Biomedical Innovation, Health, and Nutrition, 7-6-8, Saito-Asagi, Ibaraki, Osaka, 567-0085, Japan.
Kinugasa K; Natural Product Biosynthesis Research Unit, RIKEN Center for Sustainable Research Science, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan.
Watanabe K; Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Takita R; Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Nogawa T; Chemical Biology Research Group, RIKEN Center for Sustainable Research Science, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan.
Hino T; Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, 4-101 Koyama-cho, Minami, Tottori, 680-8552, Japan.; Center for Research on Green Sustainable Chemistry, Tottori University, 4-101 Koyama-cho, Minami, Tottori, 680-8552, Japan.
Osada H; Chemical Biology Research Group, RIKEN Center for Sustainable Research Science, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan.
Sugita Y; Laboratory for Biomolecular Function Simulation, RIKEN Center for Biosystems Dynamics Research, 2-2-3 Minatojima-minami-machi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.; Theoretical Molecular Science Laboratory, RIKEN Cluster for Pioneering Research, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan.; Computational Biophysics Research Team, RIKEN Center for Computational Science, 7-1-26 Minatojima-minami-machi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.
Takahashi S; Natural Product Biosynthesis Research Unit, RIKEN Center for Sustainable Research Science, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan.
Nagano S; Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, 4-101 Koyama-cho, Minami, Tottori, 680-8552, Japan.; Center for Research on Green Sustainable Chemistry, Tottori University, 4-101 Koyama-cho, Minami, Tottori, 680-8552, Japan.
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Źródło :
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2021 Oct 04; Vol. 60 (41), pp. 22401-22410. Date of Electronic Publication: 2021 Jul 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Naphthalenes/*metabolism
Pyrrolidinones/*metabolism
Tetrahydronaphthalenes/*metabolism
Models, Molecular ; Molecular Conformation ; Naphthalenes/chemistry ; Stereoisomerism
Czasopismo naukowe
Tytuł :
A Capture Strategy for the Identification of Thio-Templated Metabolites.
Autorzy :
Washburn LA; Department of Chemistry, Texas A&M University, College Station, Texas 77843, United States.
Nepal KK; Department of Chemistry, Texas A&M University, College Station, Texas 77843, United States.
Watanabe CMH; Department of Chemistry, Texas A&M University, College Station, Texas 77843, United States.
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Źródło :
ACS chemical biology [ACS Chem Biol] 2021 Sep 17; Vol. 16 (9), pp. 1737-1744. Date of Electronic Publication: 2021 Aug 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Epoxy Compounds/*metabolism
Naphthalenes/*metabolism
Peptide Synthases/*metabolism
Peptides/*metabolism
Polyketide Synthases/*metabolism
Polyketides/*metabolism
Sulfhydryl Compounds/*metabolism
Bacterial Proteins ; Biosynthetic Pathways ; Epoxy Compounds/analysis ; Genes, Bacterial ; Metabolomics ; Naphthalenes/analysis ; Peptide Synthases/genetics ; Peptides/analysis ; Polyketide Synthases/genetics ; Polyketides/analysis ; Streptomyces ; Tandem Mass Spectrometry
SCR Organism :
Streptomyces sahachiroi
Czasopismo naukowe
Tytuł :
Prenatal endothelin or thromboxane receptor antagonism surpasses sympathoinhibition in improving cardiorenal malfunctions in preeclamptic rats.
Autorzy :
Habib YH; Department of Pharmacology and Therapeutics, Faculty of Pharmacy, Pharos University in Alexandria, Alexandria, Egypt.
Abdelhady SA; Department of Pharmacology and Therapeutics, Faculty of Pharmacy, Pharos University in Alexandria, Alexandria, Egypt.
Gowayed MA; Department of Pharmacology and Therapeutics, Faculty of Pharmacy, Pharos University in Alexandria, Alexandria, Egypt.
El-Deeb NM; Department of Clinical Pathology, Faculty of Medicine, Alexandria University, Egypt.
Darwish IE; Department of Pharmacology and Therapeutics, Faculty of Pharmacy, Pharos University in Alexandria, Alexandria, Egypt; Department of Clinical Pharmacology, Faculty of Medicine, Alexandria University, Egypt.
El-Mas MM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Egypt; Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, Kuwait. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2021 Sep 01; Vol. 426, pp. 115615. Date of Electronic Publication: 2021 Jun 06.
Typ publikacji :
Journal Article
MeSH Terms :
Atrasentan/*therapeutic use
Endothelin A Receptor Antagonists/*therapeutic use
Heart Diseases/*prevention & control
Kidney Diseases/*prevention & control
Naphthalenes/*therapeutic use
Pre-Eclampsia/*drug therapy
Propionates/*therapeutic use
Receptors, Thromboxane A2, Prostaglandin H2/*antagonists & inhibitors
Animals ; Atrasentan/pharmacology ; Endothelin A Receptor Antagonists/pharmacology ; Female ; Gene Expression Regulation/drug effects ; Heart Diseases/genetics ; Heart Diseases/pathology ; Heart Diseases/physiopathology ; Hemodynamics/drug effects ; Kidney/drug effects ; Kidney/metabolism ; Kidney/pathology ; Kidney Diseases/genetics ; Kidney Diseases/pathology ; Kidney Diseases/physiopathology ; Myocardium/metabolism ; Myocardium/pathology ; Naphthalenes/pharmacology ; Pre-Eclampsia/genetics ; Pre-Eclampsia/pathology ; Pre-Eclampsia/physiopathology ; Pregnancy ; Propionates/pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptor, Endothelin A/genetics ; Receptors, Thromboxane A2, Prostaglandin H2/genetics
Czasopismo naukowe
Tytuł :
Repeated exposure to JWH-018 induces adaptive changes in the mesolimbic and mesocortical dopaminergic pathways, glial cells alterations, and behavioural correlates.
Autorzy :
Pintori N; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Castelli MP; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Miliano C; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.; School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.
Simola N; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Fadda P; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.; Institute of Neuroscience-Cagliari, National Research Council, Rome, Italy.
Fattore L; Institute of Neuroscience-Cagliari, National Research Council, Rome, Italy.
Scherma M; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Ennas MG; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Mostallino R; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Flore G; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
De Felice M; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Sagheddu C; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Pistis M; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.; Institute of Neuroscience-Cagliari, National Research Council, Rome, Italy.
Di Chiara G; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.; Institute of Neuroscience-Cagliari, National Research Council, Rome, Italy.
De Luca MA; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
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Źródło :
British journal of pharmacology [Br J Pharmacol] 2021 Sep; Vol. 178 (17), pp. 3476-3497. Date of Electronic Publication: 2021 Jun 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dopamine*
Naphthalenes*/pharmacology
Animals ; Indoles/pharmacology ; Neuroglia ; Nucleus Accumbens ; Rats
Czasopismo naukowe
Tytuł :
Design, synthesis and biological evaluation of novel thiazole-naphthalene derivatives as potential anticancer agents and tubulin polymerisation inhibitors.
Autorzy :
Wang G; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, Guiyang, China.
Liu W; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, Guiyang, China.; School of Pharmacy, Guizhou Medical University, Guiyang, China.
Fan M; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, Guiyang, China.; School of Pharmacy, Guizhou Medical University, Guiyang, China.
He M; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, Guiyang, China.; School of Pharmacy, Guizhou Medical University, Guiyang, China.
Li Y; Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Medical University, Guiyang, China.
Peng Z; College of Food Science and Technology, Shanghai Ocean University, Shanghai, China.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 1694-1702.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Antineoplastic Agents/*pharmacology
Naphthalenes/*pharmacology
Thiazoles/*pharmacology
Tubulin/*metabolism
Tubulin Modulators/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Naphthalenes/chemical synthesis ; Naphthalenes/chemistry ; Polymerization/drug effects ; Structure-Activity Relationship ; Thiazoles/chemical synthesis ; Thiazoles/chemistry ; Tubulin Modulators/chemical synthesis ; Tubulin Modulators/chemistry
Czasopismo naukowe
Tytuł :
Antagonistic Interaction between Histone Deacetylase Inhibitor: Cambinol and Cisplatin-An Isobolographic Analysis in Breast Cancer In Vitro Models.
Autorzy :
Hałasa M; Department of Biochemistry and Molecular Biology, Medical University of Lublin, Chodzki 1 Street, 20-093 Lublin, Poland.
Łuszczki JJ; Department of Pathophysiology, Medical University, Jaczewskiego 8 Street, 20-090 Lublin, Poland.
Dmoszyńska-Graniczka M; Department of Biochemistry and Molecular Biology, Medical University of Lublin, Chodzki 1 Street, 20-093 Lublin, Poland.
Baran M; Department of Biochemistry and Molecular Biology, Medical University of Lublin, Chodzki 1 Street, 20-093 Lublin, Poland.
Okoń E; Department of Biochemistry and Molecular Biology, Medical University of Lublin, Chodzki 1 Street, 20-093 Lublin, Poland.
Stepulak A; Department of Biochemistry and Molecular Biology, Medical University of Lublin, Chodzki 1 Street, 20-093 Lublin, Poland.
Wawruszak A; Department of Biochemistry and Molecular Biology, Medical University of Lublin, Chodzki 1 Street, 20-093 Lublin, Poland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 09; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 09.
Typ publikacji :
Journal Article
MeSH Terms :
Cisplatin*/antagonists & inhibitors
Cisplatin*/pharmacology
Drug Antagonism*
Models, Biological*
Naphthalenes*/antagonists & inhibitors
Naphthalenes*/pharmacology
Pyrimidinones*/antagonists & inhibitors
Pyrimidinones*/pharmacology
Breast Neoplasms/*drug therapy
Histone Deacetylase Inhibitors/*pharmacology
Apoptosis/drug effects ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Cycle/drug effects ; Female ; Humans ; MCF-7 Cells
Czasopismo naukowe
Tytuł :
Dihydroisocoumarins, Naphthalenes, and Further Polyketides from Aloe vera and A. plicatilis : Isolation, Identification and Their 5-LOX/COX-1 Inhibiting Potency.
Autorzy :
Rauwald HW; Department of Pharmaceutical Biology, Leipzig University, Johannisallee 21-23, 04103 Leipzig, Germany.
Maucher R; Department of Pharmaceutical Biology, Leipzig University, Johannisallee 21-23, 04103 Leipzig, Germany.
Dannhardt G; Department of Pharmaceutical and Medicinal Chemistry, Johannes Gutenberg-University, 55122 Mainz, Germany.
Kuchta K; Department of Pharmaceutical Biology, Leipzig University, Johannisallee 21-23, 04103 Leipzig, Germany.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Jul 12; Vol. 26 (14). Date of Electronic Publication: 2021 Jul 12.
Typ publikacji :
Journal Article
MeSH Terms :
Aloe/*chemistry
Coumarins/*chemistry
Cyclooxygenase 1/*metabolism
Cyclooxygenase Inhibitors/*chemistry
Lipoxygenase Inhibitors/*chemistry
Naphthalenes/*chemistry
Polyketides/*chemistry
Anthraquinones/chemistry ; Anthraquinones/pharmacology ; Anti-Inflammatory Agents ; Arachidonate 5-Lipoxygenase/metabolism ; Chromones/chemistry ; Chromones/pharmacology ; Coumarins/pharmacology ; Cyclooxygenase Inhibitors/pharmacology ; Glucosides/chemistry ; Glucosides/pharmacology ; Lipoxygenase Inhibitors/pharmacology ; Naphthalenes/pharmacology ; Phenols/chemistry ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Polyketides/pharmacology
Czasopismo naukowe
Tytuł :
Characterization of Phase I Hepatic Metabolites of Anti-Premature Ejaculation Drug Dapoxetine by UHPLC-ESI-Q-TOF.
Autorzy :
Skibiński R; Department of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland.
Trawiński J; Department of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland.
Gawlik M; Department of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Jun 22; Vol. 26 (13). Date of Electronic Publication: 2021 Jun 22.
Typ publikacji :
Journal Article
MeSH Terms :
Benzylamines*/chemistry
Benzylamines*/pharmacokinetics
Computer Simulation*
Naphthalenes*/chemistry
Naphthalenes*/pharmacokinetics
Microsomes, Liver/*chemistry
Biotransformation ; Chromatography, High Pressure Liquid ; Humans
Czasopismo naukowe
Tytuł :
Photoconversion of polychlorinated naphthalenes in organic solvents under simulated sunlight: Solvent effect and mechanism.
Autorzy :
Kang Q; Northern Region Persistent Organic Pollution Control (NRPOP) Laboratory, Faculty of Engineering and Applied Science, Memorial University of Newfoundland, St. John's, NL, A1B 3X5, Canada.
Bao S; College of Environment and Resources, Jilin University, Changchun, 130012, China; School of Chemistry and Environmental Engineering, Changchun University of Science and Technology, Changchun, 130022, China. Electronic address: .
Chen B; Northern Region Persistent Organic Pollution Control (NRPOP) Laboratory, Faculty of Engineering and Applied Science, Memorial University of Newfoundland, St. John's, NL, A1B 3X5, Canada. Electronic address: .
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Źródło :
Chemosphere [Chemosphere] 2021 Jun; Vol. 272, pp. 129887. Date of Electronic Publication: 2021 Feb 08.
Typ publikacji :
Journal Article
MeSH Terms :
Naphthalenes*
Sunlight*
Chlorophyll A ; Methanol ; Solvents
Czasopismo naukowe
Tytuł :
Chemical space exploration of novel naphthyl-carboxamide-diarylpyrimidine derivatives with potent anti-HIV-1 activity.
Autorzy :
Sang Y; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, People's Republic of China; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai 200433, People's Republic of China.
Pannecouque C; Rega Institute for Medical Research, KU Leuven, Herestraat 49, B-3000 Leuven, Belgium.
De Clercq E; Rega Institute for Medical Research, KU Leuven, Herestraat 49, B-3000 Leuven, Belgium.
Zhuang C; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, People's Republic of China; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai 200433, People's Republic of China. Electronic address: .
Chen F; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, People's Republic of China; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai 200433, People's Republic of China. Electronic address: .
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2021 Jun; Vol. 111, pp. 104905. Date of Electronic Publication: 2021 Apr 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-HIV Agents/*pharmacology
HIV/*drug effects
Naphthalenes/*pharmacology
Pyrimidines/*pharmacology
Anti-HIV Agents/chemical synthesis ; Anti-HIV Agents/chemistry ; Dose-Response Relationship, Drug ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Molecular Structure ; Naphthalenes/chemical synthesis ; Naphthalenes/chemistry ; Pyrimidines/chemical synthesis ; Pyrimidines/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Enantioselective Total Synthesis of (-)-Spiroxins A, C, and D.
Autorzy :
Shu X; Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an, 710127, China.
Chen CC; Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an, 710127, China.
Yu T; Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an, 710127, China.
Yang J; Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an, 710127, China.
Hu X; Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an, 710127, China.
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Źródło :
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2021 Aug 16; Vol. 60 (34), pp. 18514-18518. Date of Electronic Publication: 2021 Jul 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Naphthalenes/*chemical synthesis
Spiro Compounds/*chemical synthesis
Molecular Structure ; Naphthalenes/chemistry ; Spiro Compounds/chemistry ; Stereoisomerism
Czasopismo naukowe
Tytuł :
Tuning of the optoelectronic properties of peptide-appended core-substituted naphthalenediimides: the role of self-assembly of two positional isomers.
Autorzy :
Gayen K; School of Biological Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata, 700032, India. .
Hazra S; School of Biological Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata, 700032, India. .
Pal AK; School of Chemical Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata, 700032, India.
Paul S; School of Biological Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata, 700032, India. .
Datta A; School of Chemical Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata, 700032, India.
Banerjee A; School of Biological Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata, 700032, India. .
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Źródło :
Soft matter [Soft Matter] 2021 Aug 05; Vol. 17 (30), pp. 7168-7176.
Typ publikacji :
Journal Article
MeSH Terms :
Imides*
Naphthalenes*
Peptides ; Spectroscopy, Fourier Transform Infrared
Czasopismo naukowe
Tytuł :
Photosynthesis-Inhibiting Activity of N -(Disubstituted-phenyl)-3-hydroxynaphthalene-2-carboxamides.
Autorzy :
Kos J; Department of Biochemistry, Faculty of Medicine, Masaryk University, Kamenice 5, 62500 Brno, Czech Republic.
Gonec T; Department of Chemical Drugs, Faculty of Pharmacy, Masaryk University, Palackeho tr. 1946/1, 61200 Brno, Czech Republic.
Oravec M; Global Change Research Institute of the Czech Academy of Sciences, Belidla 986/4a, 60300 Brno, Czech Republic.
Jendrzejewska I; Institute of Chemistry, University of Silesia, Szkolna 9, 40007 Katowice, Poland.
Jampilek J; Department of Analytical Chemistry, Faculty of Natural Sciences, Comenius University, Ilkovicova 6, 84215 Bratislava, Slovakia.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Jul 17; Vol. 26 (14). Date of Electronic Publication: 2021 Jul 17.
Typ publikacji :
Journal Article
MeSH Terms :
Chloroplasts/*drug effects
Naphthalenes/*metabolism
Photosynthesis/*drug effects
Spinacia oleracea/*drug effects
Chloroplasts/metabolism ; Electron Transport/drug effects ; Herbicides/chemistry ; Herbicides/metabolism ; Naphthalenes/chemistry ; Photosystem II Protein Complex/antagonists & inhibitors ; Photosystem II Protein Complex/metabolism ; Spinacia oleracea/metabolism
Czasopismo naukowe
Tytuł :
Spectral analysis of severely overlapping spectra based on newly developed mathematical filtration techniques and ratio spectra manipulations: An application to the concurrent determination of dapoxetine and sildenafil in combined dosage form.
Autorzy :
Attala K; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo 11829, Egypt.
Abd El-Hay SS; Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.
El-Henawee MM; Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.
Eissa MS; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo 11829, Egypt. Electronic address: .
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Źródło :
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2021 Jul 05; Vol. 255, pp. 119715. Date of Electronic Publication: 2021 Mar 19.
Typ publikacji :
Journal Article
MeSH Terms :
Benzylamines*
Naphthalenes*
Sildenafil Citrate ; Spectrophotometry
Czasopismo naukowe
Tytuł :
From BN-Naphthalenes to Benzoborole Dianions.
Autorzy :
Zhu D; State Key Laboratory of Elemento-Organic Chemistry and College of Chemistry, Nankai University, Tianjin, 300071, China.
Guo L; State Key Laboratory of Elemento-Organic Chemistry and College of Chemistry, Nankai University, Tianjin, 300071, China.
Li J; State Key Laboratory of Elemento-Organic Chemistry and College of Chemistry, Nankai University, Tianjin, 300071, China.
Cui C; State Key Laboratory of Elemento-Organic Chemistry and College of Chemistry, Nankai University, Tianjin, 300071, China.
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Źródło :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2021 Jul 02; Vol. 27 (37), pp. 9514-9518. Date of Electronic Publication: 2021 May 21.
Typ publikacji :
Journal Article
MeSH Terms :
Metals, Alkali*
Naphthalenes*
Lithium
Czasopismo naukowe

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