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Tytuł :
Isohemigossypolone: Antiophidic properties of a naphthoquinone isolated from Pachira aquatica Aubl.
Autorzy :
Vieira SAPB; Institute of Genetics and Biochemistry, Federal University of Uberlândia (UFU), Uberlândia, MG, Brazil.
Dos Santos BM; Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo (USP), São Paulo, SP, Brazil.
Santos Júnior CD; Institute of Genetics and Biochemistry, Federal University of Uberlândia (UFU), Uberlândia, MG, Brazil.
de Paula VF; Laboratory of Natural Products, Department of Sciences and Technology, State University of Bahia Southwest (UESB), Jequié, BA, Brazil.
Gomes MSR; Institute of Genetics and Biochemistry, Federal University of Uberlândia (UFU), Uberlândia, MG, Brazil.
Ferreira GM; Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo (USP), São Paulo, SP, Brazil.
Gonçalves RL; Collaborative Nucleus of BioSystems, Federal University of Goiás (UFG), Jataí, GO, Brazil.
Hirata MH; Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo (USP), São Paulo, SP, Brazil.
da Silva RA; Collaborative Nucleus of BioSystems, Federal University of Goiás (UFG), Jataí, GO, Brazil.
Brandeburgo MIH; Institute of Genetics and Biochemistry, Federal University of Uberlândia (UFU), Uberlândia, MG, Brazil.
Mendes MM; Special Academic Unit of Biosciences, Federal University of Goiás (UFG), Jataí, GO, Brazil. Electronic address: .
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Źródło :
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP [Comp Biochem Physiol C Toxicol Pharmacol] 2021 Jul; Vol. 245, pp. 109028. Date of Electronic Publication: 2021 Mar 03.
Typ publikacji :
Journal Article
MeSH Terms :
Naphthoquinones*/chemistry
Naphthoquinones*/pharmacology
Plant Extracts*/pharmacology
Bombacaceae/*chemistry
Crotalid Venoms/*antagonists & inhibitors
Snake Bites/*drug therapy
Animals ; Male ; Metalloproteases/metabolism ; Mice ; Phospholipases A2/metabolism ; Plant Bark/chemistry
Czasopismo naukowe
Tytuł :
Shikonin ameliorates injury and inflammatory response of LPS-stimulated WI-38 cells via modulating the miR-489-3p/MAP2K1 axis.
Autorzy :
Wang J; Department of Pharmacy, Jiangsu Health vocational college, Nanjing 211800, Jiangsu, China.
Chen Z; Department of Outpatient, Jurong People's Hospital, Zhenjiang 212400, Jiangsu, China.
Feng X; Department of Comprehensive ICU, Luoyang Central Hospital, Luoyang 471009, Henan, China.
Yin L; Department of Comprehensive ICU, Luoyang Central Hospital, Luoyang 471009, Henan, China.
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Źródło :
Environmental toxicology [Environ Toxicol] 2021 Sep; Vol. 36 (9), pp. 1775-1784. Date of Electronic Publication: 2021 Jun 05.
Typ publikacji :
Journal Article
MeSH Terms :
MicroRNAs*/genetics
Naphthoquinones*/pharmacology
Apoptosis ; Lipopolysaccharides/toxicity
Czasopismo naukowe
Tytuł :
Nanocomposite gels of poloxamine and Laponite for β-Lapachone release in anticancer therapy.
Autorzy :
Câmara GBM; Drug Development Laboratory, Department of Pharmacy, Federal University of Rio Grande do Norte, 59010-180 Natal, RN, Brazil.
Barbosa RM; Drug Development Laboratory, Department of Pharmacy, Federal University of Rio Grande do Norte, 59010-180 Natal, RN, Brazil. Electronic address: .
García-Villén F; Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, Campus of Cartuja s/n, 18071Granada, Spain.
Viseras C; Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, Campus of Cartuja s/n, 18071Granada, Spain; Andalusian Institute of Earth Sciences, Spanish National Research Council-University of Granada (CSIC-UGR), Av. de Las Palmeras, 4, 18100Armilla, Granada, Spain.
Almeida Júnior RF; Immunology Laboratory, Pharmacy Faculty, Federal University of Rio Grande do Norte, 59010-180 Natal, RN, Brazil.
Machado PRL; Immunology Laboratory, Pharmacy Faculty, Federal University of Rio Grande do Norte, 59010-180 Natal, RN, Brazil.
Câmara CA; Department of Chemistry, Federal Rural University of Pernambuco, Recife, Pernambuco, Brazil.
Farias KJS; Center of Education and Health, Federal University of Campina Grande, Campina Grande, PB 58175-000, Brazil.
de Lima E Moura TFA; Drug Development Laboratory, Department of Pharmacy, Federal University of Rio Grande do Norte, 59010-180 Natal, RN, Brazil.
Dreiss CA; King's College London, Institute of Pharmaceutical Science, School of Cancer and Pharmaceutical Sciences, Franklin-Wilkins Building, 150 Stamford Street, SE1 9NH London, United Kingdom.
Raffin FN; Drug Development Laboratory, Department of Pharmacy, Federal University of Rio Grande do Norte, 59010-180 Natal, RN, Brazil.
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Źródło :
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2021 Aug 01; Vol. 163, pp. 105861. Date of Electronic Publication: 2021 Apr 27.
Typ publikacji :
Journal Article
MeSH Terms :
Micelles*
Naphthoquinones*
Nanogels ; Polyethylene Glycols ; Silicates ; Solubility
Czasopismo naukowe
Tytuł :
Sedative-hypnotic effect and in silico study of dinaphthodiospyrols isolated from Diospyros lotus Linn.
Autorzy :
Al-Awthan YS; Department of Biology, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia; Department of Biology, Faculty of Science, Ibb University, Ibb, Yemen.
Rauf A; Department of Chemistry, University of Swabi, Swabi, Anbar 23430, Khyber Pakhtunkhwa (KP), Pakistan. Electronic address: .
Rashid U; Department of Chemistry, COMSATS University Islamabad, Islamabad 22060, Pakistan.
Bawazeer S; Pharmacognosy Department, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.
Naz S; Department of Biotechnology, Woman University Mardan, Khyber Pakhtunkhwa, Pakistan.
Bahattab O; Department of Biology, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia.
Bawazeer S; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Umm Al-Qura University, P.O. Box 42, Makkah, Saudi Arabia.
Muhammad N; Department of Pharmacy, Abdul Wali Khan University Mardan, Khyber Pakhtunkhwa, Pakistan.
Waggas DS; Department of Pharmacology, Fakeeh College for Medical Sciences, Jeddah, Saudi Arabia.
Batiha GE; Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, El-Beheira, Egypt.
Shariati MA; K.G. Razumovsky Moscow State University of Technologies and Management (the First Cossack University), Moscow, Russian Federation.
Derkho M; South-Ural State Agrarian University, Troitsk, Russian Federation.
Suleria HAR; School of Agriculture and Food, The University of Melbourne, Parkville, VIC 3010, Australia.
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Aug; Vol. 140, pp. 111745. Date of Electronic Publication: 2021 May 19.
Typ publikacji :
Journal Article
MeSH Terms :
Hypnotics and Sedatives/*pharmacology
Naphthoquinones/*pharmacology
Sleep/*drug effects
Animals ; Diospyros ; Female ; Hypnotics and Sedatives/toxicity ; Male ; Mice ; Molecular Docking Simulation ; Naphthoquinones/toxicity ; Plant Roots ; Receptors, GABA/metabolism
Czasopismo naukowe
Tytuł :
Detecting Attomolar DNA-Damaging Anticancer Drug Activity in Cell Lysates with Electrochemical DNA Devices.
Autorzy :
Wettasinghe AP; Department of Physics, The University of Texas at Dallas, 800 W. Campbell Road, SCI 10, Richardson, Texas 75080, United States.
Singh N; Department of Biochemistry and Molecular Biology, Simon Comprehensive Cancer Center, Indiana University School of Medicine, 980 W. Walnut Street, Walther Hall R3 C551, Indianapolis, Indiana 46202, United States.
Starcher CL; Department of Biochemistry and Molecular Biology, Simon Comprehensive Cancer Center, Indiana University School of Medicine, 980 W. Walnut Street, Walther Hall R3 C551, Indianapolis, Indiana 46202, United States.
DiTusa CC; Department of Physics, The University of Texas at Dallas, 800 W. Campbell Road, SCI 10, Richardson, Texas 75080, United States.
Ishak-Boushaki Z; Department of Physics, The University of Texas at Dallas, 800 W. Campbell Road, SCI 10, Richardson, Texas 75080, United States.
Kahanda D; Department of Physics, The University of Texas at Dallas, 800 W. Campbell Road, SCI 10, Richardson, Texas 75080, United States.; Department of Physics, University of Peradeniya, Peradeniya 20400, Sri Lanka.
McMullen R; Department of Physics, The University of Texas at Dallas, 800 W. Campbell Road, SCI 10, Richardson, Texas 75080, United States.
Motea EA; Department of Biochemistry and Molecular Biology, Simon Comprehensive Cancer Center, Indiana University School of Medicine, 980 W. Walnut Street, Walther Hall R3 C551, Indianapolis, Indiana 46202, United States.
Slinker JD; Department of Physics, The University of Texas at Dallas, 800 W. Campbell Road, SCI 10, Richardson, Texas 75080, United States.; Department of Materials Science and Engineering, The University of Texas at Dallas, 800 W. Campbell Road, SCI 10, Richardson, Texas 75080, United States.
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Źródło :
ACS sensors [ACS Sens] 2021 Jul 23; Vol. 6 (7), pp. 2622-2629. Date of Electronic Publication: 2021 Jun 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antineoplastic Agents*/pharmacology
Naphthoquinones*
Cell Line, Tumor ; DNA/genetics ; Kinetics ; NAD(P)H Dehydrogenase (Quinone)/genetics ; NAD(P)H Dehydrogenase (Quinone)/metabolism
Czasopismo naukowe
Tytuł :
Tridentate 3-Substituted Naphthoquinone Ruthenium Arene Complexes: Synthesis, Characterization, Aqueous Behavior, and Theoretical and Biological Studies.
Autorzy :
Geisler H; Faculty of Chemistry, Institute of Inorganic Chemistry, University of Vienna, Waehringer Str. 42, 1090 Vienna, Austria.
Westermayr J; Department of Chemistry, University of Warwick, Gibbet Hill, Coventry, CV47AL, United Kingdom.
Cseh K; Faculty of Chemistry, Institute of Inorganic Chemistry, University of Vienna, Waehringer Str. 42, 1090 Vienna, Austria.
Wenisch D; Faculty of Chemistry, Institute of Inorganic Chemistry, University of Vienna, Waehringer Str. 42, 1090 Vienna, Austria.
Fuchs V; Faculty of Chemistry, Institute of Inorganic Chemistry, University of Vienna, Waehringer Str. 42, 1090 Vienna, Austria.
Harringer S; Faculty of Chemistry, Institute of Inorganic Chemistry, University of Vienna, Waehringer Str. 42, 1090 Vienna, Austria.
Plutzar S; Faculty of Chemistry, Institute of Inorganic Chemistry, University of Vienna, Waehringer Str. 42, 1090 Vienna, Austria.
Gajic N; Faculty of Chemistry, Institute of Inorganic Chemistry, University of Vienna, Waehringer Str. 42, 1090 Vienna, Austria.
Hejl M; Faculty of Chemistry, Institute of Inorganic Chemistry, University of Vienna, Waehringer Str. 42, 1090 Vienna, Austria.
Jakupec MA; Faculty of Chemistry, Institute of Inorganic Chemistry, University of Vienna, Waehringer Str. 42, 1090 Vienna, Austria.; Research Cluster 'Translational Cancer Therapy Research', University of Vienna, Waehringer Str. 42, A-1090 Vienna, Austria.
Marquetand P; Faculty of Chemistry, Institute of Theoretical Chemistry, University of Vienna, Waehringer Str. 17, A-1090 Vienna, Austria.; Vienna Research Platform on Accelerating Photoreaction Discovery, University of Vienna, Währinger Str. 17, 1090 Wien, Austria.
Kandioller W; Faculty of Chemistry, Institute of Inorganic Chemistry, University of Vienna, Waehringer Str. 42, 1090 Vienna, Austria.; Research Cluster 'Translational Cancer Therapy Research', University of Vienna, Waehringer Str. 42, A-1090 Vienna, Austria.
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Źródło :
Inorganic chemistry [Inorg Chem] 2021 Jul 05; Vol. 60 (13), pp. 9805-9819. Date of Electronic Publication: 2021 Jun 11.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Coordination Complexes/*pharmacology
Naphthoquinones/*pharmacology
Ruthenium/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Coordination Complexes/chemical synthesis ; Coordination Complexes/chemistry ; Crystallography, X-Ray ; Density Functional Theory ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Models, Molecular ; Molecular Structure ; Naphthoquinones/chemistry ; Ruthenium/chemistry ; Water/chemistry
Czasopismo naukowe
Tytuł :
Molecular interaction of cytotoxic anticancer analogues as inhibitors of β-tubulin protein against UACC-62 melanoma cell.
Autorzy :
Chen KC; School of Pharmacy.
Wu CR; Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources.
Lien JC; School of Pharmacy.; Master Program of Pharmaceutical Manufacture, China Medical University, Taichung 40402, Taiwan.; Department of Medical Research, Hospital of China Medical University, Taichung 40402, Taiwan.
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Źródło :
Journal of biochemistry [J Biochem] 2021 Jul 03; Vol. 169 (5), pp. 621-627.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Docking Simulation*
Molecular Dynamics Simulation*
Antineoplastic Agents/*chemistry
Melanoma/*drug therapy
Naphthoquinones/*chemistry
Neoplasm Proteins/*chemistry
Tubulin/*chemistry
Antineoplastic Agents/therapeutic use ; Humans ; Naphthoquinones/therapeutic use
Czasopismo naukowe
Tytuł :
Effects of shikonin on the development of ovarian follicles and female germline stem cells.
Autorzy :
Ma SX; Key Laboratory of Reproductive Physiology and Pathology of Jiangxi Province, Nanchang University, Nanchang, Jiangxi Province, China.; Queen Mary School, Jiangxi Medical College of Nanchang University, Nanchang, Jiangxi Province, China.
Tang LB; Second Clinical Medical College, Nanchang University, Nanchang, Jiangxi Province, China.
Chen ZH; Key Laboratory of Reproductive Physiology and Pathology of Jiangxi Province, Nanchang University, Nanchang, Jiangxi Province, China.; Queen Mary School, Jiangxi Medical College of Nanchang University, Nanchang, Jiangxi Province, China.
Wei ML; Key Laboratory of Reproductive Physiology and Pathology of Jiangxi Province, Nanchang University, Nanchang, Jiangxi Province, China.
Tang ZJ; Key Laboratory of Reproductive Physiology and Pathology of Jiangxi Province, Nanchang University, Nanchang, Jiangxi Province, China.
Zheng YH; Key Laboratory of Reproductive Physiology and Pathology of Jiangxi Province, Nanchang University, Nanchang, Jiangxi Province, China.
Zong G; Shanghai Horizon Medical Technology Co., Ltd, Shanghai, China.
Li J; Key Laboratory of Reproductive Physiology and Pathology of Jiangxi Province, Nanchang University, Nanchang, Jiangxi Province, China.
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Źródło :
The Journal of international medical research [J Int Med Res] 2021 Jul; Vol. 49 (7), pp. 3000605211029461.
Typ publikacji :
Journal Article
MeSH Terms :
Naphthoquinones*
Oogonial Stem Cells*
Animals ; Apoptosis ; Female ; Mice ; Ovarian Follicle
Czasopismo naukowe
Tytuł :
A new synthetic antitumor naphthoquinone induces ROS-mediated apoptosis with activation of the JNK and p38 signaling pathways.
Autorzy :
de Almeida PDO; Laboratory of Biological Activity, Faculty of Pharmaceutical Sciences, Federal University of Amazonas - UFAM, Manaus, Amazonas, 69077-000, Brazil.
Dos Santos Barbosa Jobim G; Laboratory of Biological Activity, Faculty of Pharmaceutical Sciences, Federal University of Amazonas - UFAM, Manaus, Amazonas, 69077-000, Brazil.
Dos Santos Ferreira CC; Laboratory of Biological Activity, Faculty of Pharmaceutical Sciences, Federal University of Amazonas - UFAM, Manaus, Amazonas, 69077-000, Brazil.
Rocha Bernardes L; Laboratory of Biological Activity, Faculty of Pharmaceutical Sciences, Federal University of Amazonas - UFAM, Manaus, Amazonas, 69077-000, Brazil.
Dias RB; Laboratory of Pathology and Molecular Biology, Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador, Bahia, 40296-710, Brazil.
Schlaepfer Sales CB; Laboratory of Pathology and Molecular Biology, Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador, Bahia, 40296-710, Brazil; Department of Biomorphology, Institute of Health Sciences, Federal University of Bahia - UFBA, Salvador, Bahia, 40110-902, Brazil.
Valverde LF; Laboratory of Pathology and Molecular Biology, Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador, Bahia, 40296-710, Brazil.
Rocha CAG; Laboratory of Pathology and Molecular Biology, Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador, Bahia, 40296-710, Brazil.
Soares MBP; Laboratory of Tissue Engineering and Immunopharmacology, Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador, Bahia, 40296-710, Brazil.
Bezerra DP; Laboratory of Tissue Engineering and Immunopharmacology, Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador, Bahia, 40296-710, Brazil.
de Carvalho da Silva F; Laboratory of Carbohydrate and Nucleotide Synthesis, Department of Organic Chemistry, Federal Fluminense University - UFF, Niterói, Rio de Janeiro, 24020-141, Brazil.
Cardoso MFDC; Laboratory of Carbohydrate and Nucleotide Synthesis, Department of Organic Chemistry, Federal Fluminense University - UFF, Niterói, Rio de Janeiro, 24020-141, Brazil.
Ferreira VF; Laboratory of Carbohydrate and Nucleotide Synthesis, Department of Organic Chemistry, Federal Fluminense University - UFF, Niterói, Rio de Janeiro, 24020-141, Brazil.
Brito LF; Laboratory of Signaling in Inflammation, Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Minas Gerais - UFMG, Belo Horizonte, Minas Gerais, 31270-901, Brazil.
Pires de Sousa L; Laboratory of Signaling in Inflammation, Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Minas Gerais - UFMG, Belo Horizonte, Minas Gerais, 31270-901, Brazil.
de Vasconcellos MC; Laboratory of Biological Activity, Faculty of Pharmaceutical Sciences, Federal University of Amazonas - UFAM, Manaus, Amazonas, 69077-000, Brazil.
Lima ES; Laboratory of Biological Activity, Faculty of Pharmaceutical Sciences, Federal University of Amazonas - UFAM, Manaus, Amazonas, 69077-000, Brazil. Electronic address: .
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2021 Jul 01; Vol. 343, pp. 109444. Date of Electronic Publication: 2021 Apr 30.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Apoptosis/*drug effects
MAP Kinase Signaling System/*drug effects
Melanoma/*drug therapy
Naphthoquinones/*therapeutic use
Reactive Oxygen Species/*metabolism
Animals ; Antineoplastic Agents/pharmacology ; Caspases/metabolism ; Cell Line, Tumor ; DNA/metabolism ; DNA Fragmentation/drug effects ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; MAP Kinase Kinase 4/metabolism ; Membrane Potential, Mitochondrial/drug effects ; Mice, Inbred C57BL ; Mitochondria/metabolism ; Naphthoquinones/pharmacology ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
Beta-lapachone: Natural occurrence, physicochemical properties, biological activities, toxicity and synthesis.
Autorzy :
Gomes CL; Laboratório de Tecnologia Dos Medicamentos, Department of Pharmaceutical Sciences, Federal University of Pernambuco, 50670-901, Av. Professor Artur de Sá, S/n - Cidade Universitária, Recife, PE, Brazil.
de Albuquerque Wanderley Sales V; Laboratório de Tecnologia Dos Medicamentos, Department of Pharmaceutical Sciences, Federal University of Pernambuco, 50670-901, Av. Professor Artur de Sá, S/n - Cidade Universitária, Recife, PE, Brazil.
Gomes de Melo C; Laboratório de Tecnologia Dos Medicamentos, Department of Pharmaceutical Sciences, Federal University of Pernambuco, 50670-901, Av. Professor Artur de Sá, S/n - Cidade Universitária, Recife, PE, Brazil.
Ferreira da Silva RM; Laboratório de Tecnologia Dos Medicamentos, Department of Pharmaceutical Sciences, Federal University of Pernambuco, 50670-901, Av. Professor Artur de Sá, S/n - Cidade Universitária, Recife, PE, Brazil.
Vicente Nishimura RH; Central de Análise de Fármacos, Medicamentos e Alimentos (CAFMA), Federal University of Vale Do São Francisco, 56304-205, Av. José de Sá Maniçoba, S/n - Centro, Petrolina, PE, Brazil.
Rolim LA; Central de Análise de Fármacos, Medicamentos e Alimentos (CAFMA), Federal University of Vale Do São Francisco, 56304-205, Av. José de Sá Maniçoba, S/n - Centro, Petrolina, PE, Brazil.
Rolim Neto PJ; Laboratório de Tecnologia Dos Medicamentos, Department of Pharmaceutical Sciences, Federal University of Pernambuco, 50670-901, Av. Professor Artur de Sá, S/n - Cidade Universitária, Recife, PE, Brazil. Electronic address: .
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Źródło :
Phytochemistry [Phytochemistry] 2021 Jun; Vol. 186, pp. 112713. Date of Electronic Publication: 2021 Mar 02.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Anti-Infective Agents*
Melanoma*
Naphthoquinones*/pharmacology
Humans ; Wound Healing
Czasopismo naukowe
Tytuł :
New naphthoquinone derivatives from Fusarium napiforme of a mangrove plant.
Autorzy :
Supratman U; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Sumedang, Indonesia.
Hirai N; Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata, Japan.
Sato S; Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata, Japan.
Watanabe K; Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata, Japan.
Malik A; Department of Geography, Faculty of Mathematics and Natural Sciences, Universitas Negeri Makassar, Makassar, Indonesia.
Annas S; Department of Statistics, Faculty of Mathematics and Natural Sciences, Universitas Negeri Makassar, Makassar, Indonesia.
Harneti D; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Sumedang, Indonesia.
Maharani R; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Sumedang, Indonesia.
Koseki T; Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata, Japan.
Shiono Y; Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata, Japan.
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Źródło :
Natural product research [Nat Prod Res] 2021 May; Vol. 35 (9), pp. 1406-1412. Date of Electronic Publication: 2019 Aug 12.
Typ publikacji :
Journal Article
MeSH Terms :
Fusarium/*chemistry
Naphthoquinones/*isolation & purification
Rhizophoraceae/*microbiology
Anti-Infective Agents/chemistry ; Anti-Infective Agents/pharmacology ; Bacteria/drug effects ; Carbon-13 Magnetic Resonance Spectroscopy ; Fungi/drug effects ; Lettuce/drug effects ; Microbial Sensitivity Tests ; Naphthoquinones/chemistry ; Naphthoquinones/pharmacology ; Proton Magnetic Resonance Spectroscopy
SCR Organism :
Fusarium napiforme
Czasopismo naukowe
Tytuł :
Regression of Melanoma Following Intravenous Injection of Plumbagin Entrapped in Transferrin-Conjugated, Lipid-Polymer Hybrid Nanoparticles.
Autorzy :
Sakpakdeejaroen I; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, G4 0RE, UK.
Somani S; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, G4 0RE, UK.
Laskar P; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, G4 0RE, UK.
Mullin M; College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK.
Dufès C; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, G4 0RE, UK.
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Źródło :
International journal of nanomedicine [Int J Nanomedicine] 2021 Apr 06; Vol. 16, pp. 2615-2631. Date of Electronic Publication: 2021 Apr 06 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Lipids/*chemistry
Melanoma, Experimental/*drug therapy
Nanoparticles/*chemistry
Naphthoquinones/*administration & dosage
Naphthoquinones/*therapeutic use
Polymers/*chemistry
Skin Neoplasms/*drug therapy
Transferrin/*metabolism
Animals ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Coumarins/pharmacology ; Coumarins/therapeutic use ; Drug Liberation ; Endocytosis/drug effects ; Female ; Humans ; Injections, Intravenous ; Melanoma, Experimental/pathology ; Mice, Inbred BALB C ; Naphthoquinones/pharmacology ; Skin Neoplasms/pathology ; Thiazoles/pharmacology ; Thiazoles/therapeutic use
Czasopismo naukowe
Tytuł :
Synthesis of novel potent cytotoxicy podophyllotoxin-naphthoquinone compounds via microwave-assited multicomponent domino reactions.
Autorzy :
Nguyen Thi QG; Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam; Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam. Electronic address: .
Le-Nhat-Thuy G; Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam; Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam. Electronic address: .
Dang Thi TA; Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam; Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam. Electronic address: .
Hoang Thi P; Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam. Electronic address: .
Nguyen Tuan A; Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam. Electronic address: .
Nguyen Thi TH; Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam. Electronic address: .
Nguyen TT; Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam. Electronic address: .
Nguyen Ha T; Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam. Electronic address: .
Hoang Mai H; Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam; Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam. Electronic address: .
Nguyen TV; Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam; Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2021 Apr 01; Vol. 37, pp. 127841. Date of Electronic Publication: 2021 Feb 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Microwaves*
Antineoplastic Agents/*pharmacology
Naphthoquinones/*pharmacology
Podophyllotoxin/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Line ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Molecular Structure ; Naphthoquinones/chemical synthesis ; Naphthoquinones/chemistry ; Podophyllotoxin/chemical synthesis ; Podophyllotoxin/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Study the interaction between juglone and calf thymus DNA by spectroscopic and molecular docking techniques.
Autorzy :
Shen B; Department of Bioengineering, School of Life Science and Technology, Changchun University of Science and Technology, NO.7186 Weixing Road, Changchun City, Jilin Province 085238, PR China. Electronic address: .
Yang H; Department of Bioengineering, School of Life Science and Technology, Changchun University of Science and Technology, NO.7186 Weixing Road, Changchun City, Jilin Province 085238, PR China.
Chen J; Department of Bioengineering, School of Life Science and Technology, Changchun University of Science and Technology, NO.7186 Weixing Road, Changchun City, Jilin Province 085238, PR China.
Liu X; Department of Bioengineering, School of Life Science and Technology, Changchun University of Science and Technology, NO.7186 Weixing Road, Changchun City, Jilin Province 085238, PR China.
Zhou M; Department of Bioengineering, School of Life Science and Technology, Changchun University of Science and Technology, NO.7186 Weixing Road, Changchun City, Jilin Province 085238, PR China.
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Źródło :
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2021 Nov 15; Vol. 261, pp. 119998. Date of Electronic Publication: 2021 May 25.
Typ publikacji :
Journal Article
MeSH Terms :
DNA*
Naphthoquinones*
Circular Dichroism ; Humans ; Molecular Docking Simulation ; Spectrometry, Fluorescence ; Spectrophotometry, Ultraviolet ; Thermodynamics
Czasopismo naukowe
Tytuł :
Plumbagin, a Natural Product with Potent Anticancer Activities, Binds to and Inhibits Dihydroorotase, a Key Enzyme in Pyrimidine Biosynthesis.
Autorzy :
Guan HH; Life Science Group, Scientific Research Division, National Synchrotron Radiation Research Center, Hsinchu 30076, Taiwan.
Huang YH; School of Biomedical Sciences, Chung Shan Medical University, No. 110, Sec.1, Chien-Kuo N. Rd., Taichung City 402, Taiwan.
Lin ES; Department of Beauty Science, National Taichung University of Science and Technology, No. 193, Sec.1, San-Min Rd., Taichung City 403, Taiwan.
Chen CJ; Life Science Group, Scientific Research Division, National Synchrotron Radiation Research Center, Hsinchu 30076, Taiwan.; Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan City 701, Taiwan.; Department of Physics, National Tsing Hua University, Hsinchu 30043, Taiwan.; Department of Biological Science and Technology, National Chiao Tung University, Hsinchu 300193, Taiwan.
Huang CY; School of Biomedical Sciences, Chung Shan Medical University, No. 110, Sec.1, Chien-Kuo N. Rd., Taichung City 402, Taiwan.; Department of Medical Research, Chung Shan Medical University Hospital, No. 110, Sec.1, Chien-Kuo N. Rd., Taichung City 402, Taiwan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 25; Vol. 22 (13). Date of Electronic Publication: 2021 Jun 25.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Phytogenic/*pharmacology
Biological Products/*pharmacology
Biosynthetic Pathways/*drug effects
Dihydroorotase/*antagonists & inhibitors
Enzyme Inhibitors/*pharmacology
Naphthoquinones/*pharmacology
Pyrimidines/*biosynthesis
Antineoplastic Agents, Phytogenic/chemistry ; Binding Sites ; Biological Products/chemistry ; Catalytic Domain ; Dihydroorotase/chemistry ; Dihydroorotase/genetics ; Enzyme Inhibitors/chemistry ; Models, Molecular ; Molecular Conformation ; Molecular Structure ; Mutation ; Naphthoquinones/chemistry ; Protein Binding ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
High-Contrast Fluorescence Diagnosis of Cancer Cells/Tissues Based on β-Lapachone-Triggered ROS Amplification Specific in Cancer Cells.
Autorzy :
Liu J; School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, 030006, China.
Liu M; School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, 030006, China.
Zhang H; School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, 030006, China.
Guo W; School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, 030006, China.
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Źródło :
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2021 Jun 01; Vol. 60 (23), pp. 12992-12998. Date of Electronic Publication: 2021 Apr 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Optical Imaging*
Adenocarcinoma, Bronchiolo-Alveolar/*diagnostic imaging
Fluorescent Dyes/*chemistry
Naphthoquinones/*chemistry
A549 Cells ; Fluorescent Dyes/chemical synthesis ; Humans ; Microscopy, Confocal ; Naphthoquinones/chemical synthesis
Czasopismo naukowe
Tytuł :
A new cytotoxic plumbagin derivative from roots of Diospyros undulata .
Autorzy :
Suchaichit N; Department of Applied Chemistry, Faculty of Sciences and Liberal Arts, Rajamangala University of Technology Isan, Nakhon Ratchasima, Thailand.
Suchaichit NP; Department of Applied Chemistry, Faculty of Sciences and Liberal Arts, Rajamangala University of Technology Isan, Nakhon Ratchasima, Thailand.
Kanokmedhakul K; Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
Boottanun P; Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Melioidosis Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Sermswan RW; Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Melioidosis Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Moosophon P; Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
Kanokmedhakul S; Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
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Źródło :
Natural product research [Nat Prod Res] 2021 May; Vol. 35 (10), pp. 1605-1612. Date of Electronic Publication: 2019 Jun 17.
Typ publikacji :
Journal Article
MeSH Terms :
Diospyros/*chemistry
Naphthoquinones/*pharmacology
Plant Roots/*chemistry
Animals ; Antineoplastic Agents/chemistry ; Bacteria/drug effects ; Cell Death/drug effects ; Cell Line, Tumor ; Chlorocebus aethiops ; Humans ; Microbial Sensitivity Tests ; Naphthoquinones/isolation & purification ; Plant Extracts/chemistry ; Vero Cells
Czasopismo naukowe
Tytuł :
NIR-Actuated Remote Activation of Ferroptosis in Target Tumor Cells through a Photothermally Responsive Iron-Chelated Biopolymer Nanoplatform.
Autorzy :
Xue C; School of Life Sciences, Chongqing University, Huxi, G75 Lanhai, Chongqing, 400044, China.
Li M; School of Life Sciences, Chongqing University, Huxi, G75 Lanhai, Chongqing, 400044, China.
Liu C; School of Life Sciences, Chongqing University, Huxi, G75 Lanhai, Chongqing, 400044, China.
Li Y; School of Life Sciences, Chongqing University, Huxi, G75 Lanhai, Chongqing, 400044, China.
Fei Y; School of Life Sciences, Chongqing University, Huxi, G75 Lanhai, Chongqing, 400044, China.
Hu Y; Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400044, China.
Cai K; Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400044, China.
Zhao Y; Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore, Singapore.
Luo Z; School of Life Sciences, Chongqing University, Huxi, G75 Lanhai, Chongqing, 400044, China.
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Źródło :
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2021 Apr 12; Vol. 60 (16), pp. 8938-8947. Date of Electronic Publication: 2021 Mar 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Biopolymers/*pharmacology
Ferroptosis/*drug effects
Iron Chelating Agents/*pharmacology
Nanoparticles/*chemistry
Naphthoquinones/*pharmacology
Animals ; Antineoplastic Agents/chemistry ; Biopolymers/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Drug Screening Assays, Antitumor ; Infrared Rays ; Iron Chelating Agents/chemistry ; Mice ; Naphthoquinones/chemistry ; Particle Size ; Phototherapy ; Surface Properties
Czasopismo naukowe
Tytuł :
Reprogramming of erythrocyte lifespan by NFκB-TNFα naphthoquinone antagonist β-lapachone is regulated by calcium overload and CK1α.
Autorzy :
Alfhili MA; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Alsughayyir J; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Basudan AM; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
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Źródło :
Journal of food biochemistry [J Food Biochem] 2021 Apr; Vol. 45 (4), pp. e13710. Date of Electronic Publication: 2021 Mar 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium*
Naphthoquinones*/pharmacology
Casein Kinase Ialpha ; Cellular Reprogramming ; Erythrocytes ; Humans ; Longevity ; Reactive Oxygen Species ; Tumor Necrosis Factor-alpha
Czasopismo naukowe
Tytuł :
Appraisal of anti-Parkinson activity of rhinacanthin-C in haloperidol-induced parkinsonism in mice: A mechanistic approach.
Autorzy :
Saleem U; Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad, Pakistan.
Gull Z; Riphah Institute of Pharmaceutical Sciences, Riphah International University Lahore, Lahore, Pakistan.
Saleem A; Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad, Pakistan.
Shah MA; Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Pakistan.
Akhtar MF; Riphah Institute of Pharmaceutical Sciences, Riphah International University Lahore, Lahore, Pakistan.
Anwar F; Riphah Institute of Pharmaceutical Sciences, Riphah International University Lahore, Lahore, Pakistan.
Ahmad B; Riphah Institute of Pharmaceutical Sciences, Riphah International University Lahore, Lahore, Pakistan.
Panichayupakaranant P; Faculty of Pharmaceutical Sciences, Phytomedicine and Pharmaceutical Biotechnology Excellence Center, Prince of Songkla University, Hat Yai, Thailand.
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Źródło :
Journal of food biochemistry [J Food Biochem] 2021 Apr; Vol. 45 (4), pp. e13677. Date of Electronic Publication: 2021 Mar 12.
Typ publikacji :
Journal Article
MeSH Terms :
Acanthaceae*
Naphthoquinones*
Parkinsonian Disorders*/chemically induced
Parkinsonian Disorders*/drug therapy
Animals ; Haloperidol/toxicity ; Mice
Czasopismo naukowe

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