Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

English (EN)·Polski (PL)·Ukraiński (UK)
Przejdź do strony domowej biblioteki Uniwersytet Ekonomiczny we Wrocławiu Link otwiera się w nowym oknie Logo biblioteki Prolib Integro - strona głównaUniwersytet Ekonomiczny we Wrocławiu

Wyszukujesz frazę ""Naphthoquinones"" wg kryterium: Temat

  Lista filtrów
Wyrównaj
Wyświetlanie 61-80 z 2845
Tytuł:
Histopathological and ultrastructural assessment of atovaquone-proguanil hydrochloride combination in chronic murine toxoplasmosis.
Autorzy:
Elmehankar MS; Department of Medical Parasitology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Elhenawy AA; Department of Medical Parasitology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Aboukamar WA; Department of Medical Parasitology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Elzoheiry MA; Department of Medical Parasitology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Nabih N; Department of Medical Parasitology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Pokaż więcej
Źródło:
Ultrastructural pathology [Ultrastruct Pathol] 2021 Nov 02; Vol. 45 (6), pp. 376-383. Date of Electronic Publication: 2021 Oct 01.
Typ publikacji:
Journal Article
MeSH Terms:
Naphthoquinones*
Toxoplasma*
Toxoplasmosis, Animal*/drug therapy
Animals ; Atovaquone/pharmacology ; Brain ; Mice ; Proguanil
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Biogenic nanoporous silicon carrier improves the efficacy of buparvaquone against resistant visceral leishmaniasis.
Autorzy:
Thapa R; Department of Applied Physics, University of Eastern Finland, Kuopio, Finland.
Mondal S; School of Pharmacy, The Neotia University, Sarisa, West Bengal, India.
Riikonen J; Department of Applied Physics, University of Eastern Finland, Kuopio, Finland.
Rantanen J; Department of Applied Physics, University of Eastern Finland, Kuopio, Finland.
Näkki S; Department of Applied Physics, University of Eastern Finland, Kuopio, Finland.
Nissinen T; Department of Applied Physics, University of Eastern Finland, Kuopio, Finland.
Närvänen A; School of Pharmacy, University of Eastern Finland, Kuopio, Finland.
Lehto VP; Department of Applied Physics, University of Eastern Finland, Kuopio, Finland.
Pokaż więcej
Źródło:
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2021 Jun 29; Vol. 15 (6), pp. e0009533. Date of Electronic Publication: 2021 Jun 29 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antiprotozoal Agents/*therapeutic use
Leishmania donovani/*drug effects
Leishmaniasis, Visceral/*drug therapy
Nanoparticles/*administration & dosage
Naphthoquinones/*therapeutic use
Animals ; Antiprotozoal Agents/administration & dosage ; Drug Carriers ; Female ; Hordeum ; Injections, Intraperitoneal ; Macrophages/drug effects ; Mice, Inbred BALB C ; Naphthoquinones/administration & dosage ; Naphthoquinones/adverse effects ; Silicon/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Anti-proliferative and pro-apoptotic activity of glycosidic derivatives of lawsone in melanoma cancer cell.
Autorzy:
de Franca MNF; Laboratory of Biology and Immunology of Cancer and Leishmania, Department of Morphology, Federal University of Sergipe, São Cristóvão, Sergipe, Brasil.; Graduate program in health sciences, Federal University of Sergipe, Aracaju, Sergipe, Brazil.
Isidório RG; Laboratory of Pharmaceutical Chemistry, Department of Pharmaceutical Products, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Bonifacio JHO; Laboratory of Biology and Immunology of Cancer and Leishmania, Department of Morphology, Federal University of Sergipe, São Cristóvão, Sergipe, Brasil.
Dos Santos EWP; Laboratory of Biology and Immunology of Cancer and Leishmania, Department of Morphology, Federal University of Sergipe, São Cristóvão, Sergipe, Brasil.; Graduate program in health sciences, Federal University of Sergipe, Aracaju, Sergipe, Brazil.
Santos JF; Laboratory of Biology and Immunology of Cancer and Leishmania, Department of Morphology, Federal University of Sergipe, São Cristóvão, Sergipe, Brasil.
Ottoni FM; Laboratory of Pharmaceutical Chemistry, Department of Pharmaceutical Products, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
de Lucca Junior W; Laboratory of Molecular Neuroscience of Sergipe, Department of Morphology, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil.
Scher R; Laboratory of Biology and Immunology of Cancer and Leishmania, Department of Morphology, Federal University of Sergipe, São Cristóvão, Sergipe, Brasil.
Alves RJ; Laboratory of Pharmaceutical Chemistry, Department of Pharmaceutical Products, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Corrêa CB; Laboratory of Biology and Immunology of Cancer and Leishmania, Department of Morphology, Federal University of Sergipe, São Cristóvão, Sergipe, Brasil. .; Graduate program in health sciences, Federal University of Sergipe, Aracaju, Sergipe, Brazil. .
Pokaż więcej
Źródło:
BMC cancer [BMC Cancer] 2021 Jun 02; Vol. 21 (1), pp. 662. Date of Electronic Publication: 2021 Jun 02.
Typ publikacji:
Journal Article
MeSH Terms:
Melanoma/*drug therapy
Naphthoquinones/*pharmacology
Skin Neoplasms/*drug therapy
Animals ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Drug Screening Assays, Antitumor ; Glycosides/chemistry ; Humans ; Melanoma/pathology ; Mice ; Naphthoquinones/chemistry ; Naphthoquinones/therapeutic use ; Skin Neoplasms/pathology ; Tumor Stem Cell Assay
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Effects of a reactive oxygen species generator, napabucasin (BBI608), on tolerability, safety, pharmacokinetics, and QT/QTc interval in healthy volunteers.
Autorzy:
Noda N; Clinical Research, Drug Development Division, Sumitomo Dainippon Pharma Co., Ltd., Tokyo, Japan.
Takagaki T; Clinical Research, Drug Development Division, Sumitomo Dainippon Pharma Co., Ltd., Osaka, Japan.
Yodo Y; Data Science, Drug Development Division, Sumitomo Dainippon Pharma Co., Ltd., Tokyo, Japan.
Horibuchi Y; Oncology Clinical Development Unit, Sumitomo Dainippon Pharma Co., Ltd., Tokyo, Japan.
Iino S; Oncology Clinical Development Unit, Sumitomo Dainippon Pharma Co., Ltd., Tokyo, Japan.
Matsuki S; Fukuoka Mirai Hospital, SOUSEIKAI, Fukuoka, Japan.
Ogama Y; Sumida Hospital, SOUSEIKAI, Tokyo, Japan.
Kakuyama H; Clinical Research, Drug Development Division, Sumitomo Dainippon Pharma Co., Ltd., Tokyo, Japan.
Pokaż więcej
Źródło:
Pharmacology research & perspectives [Pharmacol Res Perspect] 2021 Oct; Vol. 9 (5), pp. e00874.
Typ publikacji:
Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents/*pharmacology
Benzofurans/*pharmacology
Heart Conduction System/*drug effects
Naphthoquinones/*pharmacology
Abdominal Pain/chemically induced ; Antineoplastic Agents/adverse effects ; Asian People ; Benzofurans/adverse effects ; Diarrhea/chemically induced ; Double-Blind Method ; Electrocardiography ; Female ; Healthy Volunteers ; Humans ; Long QT Syndrome/chemically induced ; Male ; Naphthoquinones/adverse effects ; Reactive Oxygen Species
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A single-domain small protein Med-ORF10 regulates the production of antitumour agent medermycin in Streptomyces.
Autorzy:
Cai X; Helmholtz International Lab for Anti-Infectives, Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, China.; The College of Life Sciences, Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, Central China Normal University, Wuhan, 430079, China.; School of Pharmacy, Huazhong University of Science and Technology, Wuhan, 430030, China.
Li C; Helmholtz International Lab for Anti-Infectives, Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, China.
Ichinose K; Research Institute of Pharmaceutical Sciences, Musashino University, Tokyo, 202-8585, Japan.
Jiang Y; The College of Life Sciences, Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, Central China Normal University, Wuhan, 430079, China.
Liu M; The College of Life Sciences, Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, Central China Normal University, Wuhan, 430079, China.
Wang H; The College of Life Sciences, Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, Central China Normal University, Wuhan, 430079, China.
Gong C; The College of Life Sciences, Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, Central China Normal University, Wuhan, 430079, China.
Li L; The College of Life Sciences, Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, Central China Normal University, Wuhan, 430079, China.
Wan J; The College of Life Sciences, Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, Central China Normal University, Wuhan, 430079, China.
Zhao Y; Helmholtz International Lab for Anti-Infectives, Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, China.
Yang Q; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Songhu Road 2005, Shanghai, 200438, China.
Li A; Helmholtz International Lab for Anti-Infectives, Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, China.; The College of Life Sciences, Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, Central China Normal University, Wuhan, 430079, China.
Pokaż więcej
Źródło:
Microbial biotechnology [Microb Biotechnol] 2021 Sep; Vol. 14 (5), pp. 1918-1930. Date of Electronic Publication: 2021 Jun 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents*
Naphthoquinones*
Streptomyces*/genetics
Gene Expression Regulation, Bacterial ; Multigene Family
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Napabucasin Drug-Drug Interaction Potential, Safety, Tolerability, and Pharmacokinetics Following Oral Dosing in Healthy Adult Volunteers.
Autorzy:
Dai X; Clinical Pharmacology and Drug Metabolism, Sumitomo Dainippon Pharma Oncology, Inc., Cambridge, Massachusetts, USA.
Karol MD; Clinical Pharmacology and Drug Metabolism, Sumitomo Dainippon Pharma Oncology, Inc., Cambridge, Massachusetts, USA.
Hitron M; Clinical Development, Sumitomo Dainippon Pharma Oncology, Inc., Cambridge, Massachusetts, USA.
Hard ML; Clinical Pharmacology, Nuventra, Inc., Durham, North Carolina, USA.; Current address: Praxis Precision Medicines, Cambridge, Massachusetts, USA.
Goulet MT; Clinical Pharmacology, Nuventra, Inc., Durham, North Carolina, USA.; Current address: Program Management Department, KSQ Therapeutics, Cambridge, Massachusetts, USA.
McLaughlin CF; Pharmacokinetics, Nuventra, Inc., Durham, North Carolina, USA.
Brantley SJ; Clinical NCA & PK/PD, Nuventra, Inc., Durham, North Carolina, USA.
Pokaż więcej
Źródło:
Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2021 Aug; Vol. 10 (8), pp. 824-839. Date of Electronic Publication: 2021 Jun 09.
Typ publikacji:
Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
ATP Binding Cassette Transporter, Subfamily G, Member 2/*metabolism
Benzofurans/*administration & dosage
Cytochrome P-450 Enzyme System/*metabolism
Naphthoquinones/*administration & dosage
Neoplasm Proteins/*metabolism
Administration, Oral ; Adult ; Benzofurans/pharmacokinetics ; Bupropion/administration & dosage ; Bupropion/pharmacokinetics ; Caffeine/administration & dosage ; Caffeine/pharmacokinetics ; Dextromethorphan/administration & dosage ; Dextromethorphan/pharmacokinetics ; Drug Interactions ; Female ; Flurbiprofen/administration & dosage ; Flurbiprofen/pharmacokinetics ; Gene Expression Regulation/drug effects ; Half-Life ; Healthy Volunteers ; Humans ; Male ; Midazolam/administration & dosage ; Midazolam/pharmacokinetics ; Naphthoquinones/pharmacokinetics ; Omeprazole/administration & dosage ; Omeprazole/pharmacokinetics ; Rosuvastatin Calcium/administration & dosage ; Rosuvastatin Calcium/pharmacokinetics ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synthesis and Pharmacological In Vitro Investigations of Novel Shikonin Derivatives with a Special Focus on Cyclopropane Bearing Derivatives.
Autorzy:
Kretschmer N; Department of Pharmacognosy, Institute of Pharmaceutical Sciences, University of Graz, Beethovenstr. 8, 8010 Graz, Austria.
Hufner A; Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Sciences, University of Graz, Universitaetsplatz 1, 8010 Graz, Austria.
Durchschein C; Department of Pharmacognosy, Institute of Pharmaceutical Sciences, University of Graz, Beethovenstr. 8, 8010 Graz, Austria.
Popodi K; Department of Pharmacognosy, Institute of Pharmaceutical Sciences, University of Graz, Beethovenstr. 8, 8010 Graz, Austria.
Rinner B; Division of Biomedical Research, Medical University of Graz, Roseggerweg 48, 8036 Graz, Austria.
Lohberger B; Department of Orthopedics and Trauma, Medical University Graz, Auenbruggerplatz 5, 8036 Graz, Austria.
Bauer R; Department of Pharmacognosy, Institute of Pharmaceutical Sciences, University of Graz, Beethovenstr. 8, 8010 Graz, Austria.
Pokaż więcej
Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 09; Vol. 22 (5). Date of Electronic Publication: 2021 Mar 09.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/chemical synthesis
Antineoplastic Agents*/chemistry
Antineoplastic Agents*/pharmacology
Cyclopropanes*/chemical synthesis
Cyclopropanes*/chemistry
Cyclopropanes*/pharmacology
Naphthoquinones*/chemical synthesis
Naphthoquinones*/chemistry
Naphthoquinones*/pharmacology
Apoptosis/*drug effects
Melanoma/*drug therapy
Cell Line, Tumor ; Humans ; Melanoma/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Cytotoxicity and antigenotoxicity evaluation of acetylshikonin and shikonin.
Autorzy:
Figat R; Department of Environmental Health Sciences, Medical University of Warsaw, Poland.
Zgadzaj A; Department of Environmental Health Sciences, Medical University of Warsaw, Poland.
Geschke S; Department of Environmental Health Sciences, Medical University of Warsaw, Poland.
Sieczka P; Department of Environmental Health Sciences, Medical University of Warsaw, Poland.
Pietrosiuk A; Department of Pharmaceutical Biology and Medicinal Plant Biotechnology, Medical University of Warsaw, Poland.
Sommer S; Centre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Warsaw, Poland.
Skrzypczak A; Department of Environmental Health Sciences, Medical University of Warsaw, Poland.
Pokaż więcej
Źródło:
Drug and chemical toxicology [Drug Chem Toxicol] 2021 Mar; Vol. 44 (2), pp. 140-147. Date of Electronic Publication: 2018 Dec 21.
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
Anthraquinones/*pharmacology
DNA Damage/*drug effects
Naphthoquinones/*pharmacology
Animals ; Anthraquinones/toxicity ; Cell Line ; Cricetulus ; Cyclophosphamide/toxicity ; Ethyl Methanesulfonate/toxicity ; Fluoroquinolones/toxicity ; Micronucleus Tests ; Naphthoquinones/toxicity
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Mass balance and pharmacokinetics of an oral dose of C-napabucasin in healthy adult male subjects.
Autorzy:
Dai X; Sumitomo Dainippon Pharma Oncology, Inc., Cambridge, MA, USA.
Karol MD; Sumitomo Dainippon Pharma Oncology, Inc., Cambridge, MA, USA.
Hitron M; Sumitomo Dainippon Pharma Oncology, Inc., Cambridge, MA, USA.
Hard ML; Nuventra Inc., Durham, NC, USA.
Blanchard JE; Covance, Inc., Madison, WI, USA.
Eraut NCJE; Covance Clinical Research Unit Ltd., Leeds, UK.
Rich N; Covance, Inc., Madison, WI, USA.
Gufford BT; Covance, Inc., Madison, WI, USA.
Pokaż więcej
Źródło:
Pharmacology research & perspectives [Pharmacol Res Perspect] 2021 Feb; Vol. 9 (1), pp. e00722.
Typ publikacji:
Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents/*pharmacokinetics
Benzofurans/*pharmacokinetics
Naphthoquinones/*pharmacokinetics
Administration, Oral ; Adult ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/blood ; Antineoplastic Agents/urine ; Benzofurans/adverse effects ; Benzofurans/blood ; Benzofurans/urine ; Carbon Radioisotopes ; Feces/chemistry ; Humans ; Male ; Naphthoquinones/adverse effects ; Naphthoquinones/blood ; Naphthoquinones/urine ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Molecular interaction of cytotoxic anticancer analogues as inhibitors of β-tubulin protein against UACC-62 melanoma cell.
Autorzy:
Chen KC; School of Pharmacy.
Wu CR; Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources.
Lien JC; School of Pharmacy.; Master Program of Pharmaceutical Manufacture, China Medical University, Taichung 40402, Taiwan.; Department of Medical Research, Hospital of China Medical University, Taichung 40402, Taiwan.
Pokaż więcej
Źródło:
Journal of biochemistry [J Biochem] 2021 Jul 03; Vol. 169 (5), pp. 621-627.
Typ publikacji:
Journal Article
MeSH Terms:
Molecular Docking Simulation*
Molecular Dynamics Simulation*
Antineoplastic Agents/*chemistry
Melanoma/*drug therapy
Naphthoquinones/*chemistry
Neoplasm Proteins/*chemistry
Tubulin/*chemistry
Antineoplastic Agents/therapeutic use ; Humans ; Naphthoquinones/therapeutic use
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Plumbagin, a Natural Product with Potent Anticancer Activities, Binds to and Inhibits Dihydroorotase, a Key Enzyme in Pyrimidine Biosynthesis.
Autorzy:
Guan HH; Life Science Group, Scientific Research Division, National Synchrotron Radiation Research Center, Hsinchu 30076, Taiwan.
Huang YH; School of Biomedical Sciences, Chung Shan Medical University, No. 110, Sec.1, Chien-Kuo N. Rd., Taichung City 402, Taiwan.
Lin ES; Department of Beauty Science, National Taichung University of Science and Technology, No. 193, Sec.1, San-Min Rd., Taichung City 403, Taiwan.
Chen CJ; Life Science Group, Scientific Research Division, National Synchrotron Radiation Research Center, Hsinchu 30076, Taiwan.; Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan City 701, Taiwan.; Department of Physics, National Tsing Hua University, Hsinchu 30043, Taiwan.; Department of Biological Science and Technology, National Chiao Tung University, Hsinchu 300193, Taiwan.
Huang CY; School of Biomedical Sciences, Chung Shan Medical University, No. 110, Sec.1, Chien-Kuo N. Rd., Taichung City 402, Taiwan.; Department of Medical Research, Chung Shan Medical University Hospital, No. 110, Sec.1, Chien-Kuo N. Rd., Taichung City 402, Taiwan.
Pokaż więcej
Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 25; Vol. 22 (13). Date of Electronic Publication: 2021 Jun 25.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents, Phytogenic/*pharmacology
Biological Products/*pharmacology
Biosynthetic Pathways/*drug effects
Dihydroorotase/*antagonists & inhibitors
Enzyme Inhibitors/*pharmacology
Naphthoquinones/*pharmacology
Pyrimidines/*biosynthesis
Antineoplastic Agents, Phytogenic/chemistry ; Binding Sites ; Biological Products/chemistry ; Catalytic Domain ; Dihydroorotase/chemistry ; Dihydroorotase/genetics ; Enzyme Inhibitors/chemistry ; Models, Molecular ; Molecular Conformation ; Molecular Structure ; Mutation ; Naphthoquinones/chemistry ; Protein Binding ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Optimization of 1,4-Naphthoquinone Hit Compound: A Computational, Phenotypic, and In Vivo Screening against Trypanosoma cruzi .
Autorzy:
Lara LS; Laboratório de Ultraestrutura Celular, Instituto Oswaldo Cruz, Fiocruz, Av. Brasil 4365 Manguinhos, Rio de Janeiro 21040-900, RJ, Brazil.
Lechuga GC; Laboratório de Ultraestrutura Celular, Instituto Oswaldo Cruz, Fiocruz, Av. Brasil 4365 Manguinhos, Rio de Janeiro 21040-900, RJ, Brazil.
Moreira CDS; Departamento de Química Orgânica, Instituto de Química, Universidade Federal Fluminense, Rua Outeiro São João Batista, Niterói 24020-141, Rio de Janeiro, Brazil.
Santos TB; Departamento de Química Orgânica, Instituto de Química, Universidade Federal Fluminense, Rua Outeiro São João Batista, Niterói 24020-141, Rio de Janeiro, Brazil.
Ferreira VF; Departamento de Química Orgânica, Instituto de Química, Universidade Federal Fluminense, Rua Outeiro São João Batista, Niterói 24020-141, Rio de Janeiro, Brazil.
da Rocha DR; Departamento de Química Orgânica, Instituto de Química, Universidade Federal Fluminense, Rua Outeiro São João Batista, Niterói 24020-141, Rio de Janeiro, Brazil.
Pereira MCS; Laboratório de Ultraestrutura Celular, Instituto Oswaldo Cruz, Fiocruz, Av. Brasil 4365 Manguinhos, Rio de Janeiro 21040-900, RJ, Brazil.
Pokaż więcej
Źródło:
Molecules (Basel, Switzerland) [Molecules] 2021 Jan 15; Vol. 26 (2). Date of Electronic Publication: 2021 Jan 15.
Typ publikacji:
Journal Article
MeSH Terms:
Chagas Disease/*drug therapy
Naphthoquinones/*chemistry
Trypanocidal Agents/*pharmacology
Trypanosoma cruzi/*drug effects
Animals ; Chagas Disease/parasitology ; Computational Chemistry ; Male ; Mice ; Molecular Structure ; Naphthoquinones/pharmacology ; Parasitic Sensitivity Tests ; Structure-Activity Relationship ; Trypanocidal Agents/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Reprogramming of erythrocyte lifespan by NFκB-TNFα naphthoquinone antagonist β-lapachone is regulated by calcium overload and CK1α.
Autorzy:
Alfhili MA; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Alsughayyir J; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Basudan AM; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Pokaż więcej
Źródło:
Journal of food biochemistry [J Food Biochem] 2021 Apr; Vol. 45 (4), pp. e13710. Date of Electronic Publication: 2021 Mar 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Calcium*
Naphthoquinones*/pharmacology
Casein Kinase Ialpha ; Cellular Reprogramming ; Erythrocytes ; Humans ; Longevity ; Reactive Oxygen Species ; Tumor Necrosis Factor-alpha
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Appraisal of anti-Parkinson activity of rhinacanthin-C in haloperidol-induced parkinsonism in mice: A mechanistic approach.
Autorzy:
Saleem U; Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad, Pakistan.
Gull Z; Riphah Institute of Pharmaceutical Sciences, Riphah International University Lahore, Lahore, Pakistan.
Saleem A; Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad, Pakistan.
Shah MA; Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Pakistan.
Akhtar MF; Riphah Institute of Pharmaceutical Sciences, Riphah International University Lahore, Lahore, Pakistan.
Anwar F; Riphah Institute of Pharmaceutical Sciences, Riphah International University Lahore, Lahore, Pakistan.
Ahmad B; Riphah Institute of Pharmaceutical Sciences, Riphah International University Lahore, Lahore, Pakistan.
Panichayupakaranant P; Faculty of Pharmaceutical Sciences, Phytomedicine and Pharmaceutical Biotechnology Excellence Center, Prince of Songkla University, Hat Yai, Thailand.
Pokaż więcej
Źródło:
Journal of food biochemistry [J Food Biochem] 2021 Apr; Vol. 45 (4), pp. e13677. Date of Electronic Publication: 2021 Mar 12.
Typ publikacji:
Journal Article
MeSH Terms:
Acanthaceae*
Naphthoquinones*
Parkinsonian Disorders*/chemically induced
Parkinsonian Disorders*/drug therapy
Animals ; Haloperidol/toxicity ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Shikonin ameliorates lipoteichoic acid‑induced acute lung injury via promotion of neutrophil apoptosis.
Autorzy:
Zhang Y; Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Bengbu Medical College, Anhui Province Key Laboratory of Translational Cancer Research, Bengbu Medical College, Bengbu, Anhui 233004, P.R. China.
Zhang H; Engineering Research Center of Cell and Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, P.R. China.
Wang M; Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Bengbu Medical College, Anhui Province Key Laboratory of Translational Cancer Research, Bengbu Medical College, Bengbu, Anhui 233004, P.R. China.
Gao S; Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Bengbu Medical College, Anhui Province Key Laboratory of Translational Cancer Research, Bengbu Medical College, Bengbu, Anhui 233004, P.R. China.
Hong L; Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Bengbu Medical College, Anhui Province Key Laboratory of Translational Cancer Research, Bengbu Medical College, Bengbu, Anhui 233004, P.R. China.
Hou T; Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Bengbu Medical College, Anhui Province Key Laboratory of Translational Cancer Research, Bengbu Medical College, Bengbu, Anhui 233004, P.R. China.
Zhang Y; Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Bengbu Medical College, Anhui Province Key Laboratory of Translational Cancer Research, Bengbu Medical College, Bengbu, Anhui 233004, P.R. China.
Zhu Y; Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Bengbu Medical College, Anhui Province Key Laboratory of Translational Cancer Research, Bengbu Medical College, Bengbu, Anhui 233004, P.R. China.
Qian F; Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Bengbu Medical College, Anhui Province Key Laboratory of Translational Cancer Research, Bengbu Medical College, Bengbu, Anhui 233004, P.R. China.
Pokaż więcej
Źródło:
Molecular medicine reports [Mol Med Rep] 2021 Feb; Vol. 23 (2). Date of Electronic Publication: 2020 Dec 14.
Typ publikacji:
Journal Article
MeSH Terms:
Acute Lung Injury/*drug therapy
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Naphthoquinones/*pharmacology
Neutrophils/*cytology
Acute Lung Injury/chemically induced ; Acute Lung Injury/pathology ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Apoptosis/drug effects ; Bronchoalveolar Lavage Fluid/chemistry ; Caspase 3/metabolism ; Cytokines/metabolism ; DNA Fragmentation/drug effects ; Disease Models, Animal ; Inflammation/chemically induced ; Inflammation/drug therapy ; Lipopolysaccharides/toxicity ; Male ; Mice, Inbred C57BL ; Myeloid Cell Leukemia Sequence 1 Protein/metabolism ; Naphthoquinones/therapeutic use ; Neutrophil Infiltration/drug effects ; Neutrophils/drug effects ; Neutrophils/metabolism ; Poly(ADP-ribose) Polymerases/metabolism ; Teichoic Acids/toxicity ; Tumor Suppressor Protein p53/metabolism ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Total synthesis of lindbladione, a Hes1 dimerization inhibitor and neural stem cell activator isolated from Lindbladia tubulina.
Autorzy:
Arai MA; Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, 223-8522, Japan. midori_.
Makita Y; Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8675, Japan.
Yamaguchi Y; Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8675, Japan.
Kawano H; Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8675, Japan.
Suganami A; Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan.
Tamura Y; Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan.
Ishibashi M; Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8675, Japan. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2020 Dec 08; Vol. 10 (1), pp. 21433. Date of Electronic Publication: 2020 Dec 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Amoeba/*chemistry
Naphthoquinones/*chemical synthesis
Neural Stem Cells/*cytology
Transcription Factor HES-1/*chemistry
Transcription Factor HES-1/*metabolism
Animals ; Cell Differentiation/drug effects ; Cell Line ; Mice ; Models, Molecular ; Molecular Docking Simulation ; Molecular Structure ; Naphthoquinones/chemistry ; Naphthoquinones/pharmacology ; Neural Stem Cells/drug effects ; Neural Stem Cells/metabolism ; Protein Conformation ; Protein Multimerization/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Design, synthesis and anticancer activity of naphthoquinone derivatives.
Autorzy:
Shen XB; School of Pharmacy, Anhui Medical University, Hefei, PR China.; Engineering Research Center of Biomass Conversion and Pollution Prevention of Anhui Educational Institutions, Fuyang Normal University, Fuyang, PR China.
Wang Y; School of Pharmacy, Anhui Medical University, Hefei, PR China.
Han XZ; Engineering Research Center of Biomass Conversion and Pollution Prevention of Anhui Educational Institutions, Fuyang Normal University, Fuyang, PR China.
Sheng LQ; Engineering Research Center of Biomass Conversion and Pollution Prevention of Anhui Educational Institutions, Fuyang Normal University, Fuyang, PR China.
Wu FF; School of Pharmacy, Anhui Medical University, Hefei, PR China.; Engineering Research Center of Biomass Conversion and Pollution Prevention of Anhui Educational Institutions, Fuyang Normal University, Fuyang, PR China.
Liu X; School of Pharmacy, Anhui Medical University, Hefei, PR China.
Pokaż więcej
Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 773-785.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Design*
Antineoplastic Agents/*pharmacology
Naphthoquinones/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Naphthoquinones/chemical synthesis ; Naphthoquinones/chemistry ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Isolation and Structure Determination of Echinochrome A Oxidative Degradation Products.
Autorzy:
Mishchenko NP; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok 690022, Russia.
Vasileva EA; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok 690022, Russia.
Gerasimenko AV; Institute of Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok 690022, Russia.
Grigorchuk VP; Federal Scientific Center of the East Asia Terrestrial Biodiversity, Far-Eastern Branch of Russian Academy of Sciences, Vladivostok 690022, Russia.
Dmitrenok PS; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok 690022, Russia.
Fedoreyev SA; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok 690022, Russia.
Pokaż więcej
Źródło:
Molecules (Basel, Switzerland) [Molecules] 2020 Oct 18; Vol. 25 (20). Date of Electronic Publication: 2020 Oct 18.
Typ publikacji:
Journal Article
MeSH Terms:
Naphthoquinones/*chemistry
Oxidative Stress/*drug effects
Sea Urchins/*chemistry
Animals ; Chromatography, High Pressure Liquid ; Humans ; Magnetic Resonance Spectroscopy ; Naphthoquinones/isolation & purification ; Naphthoquinones/metabolism ; Naphthoquinones/pharmacology ; Oxidation-Reduction/drug effects ; Spectrometry, Mass, Electrospray Ionization
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synthesis and Properties of CurNQ for the Theranostic Application in Ovarian Cancer Intervention.
Autorzy:
Freidus LG; Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown 2193, South Africa.
Kumar P; Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown 2193, South Africa.
Marimuthu T; Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown 2193, South Africa.
Pradeep P; Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown 2193, South Africa.
Pillay V; Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown 2193, South Africa.
Choonara YE; Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown 2193, South Africa.
Pokaż więcej
Źródło:
Molecules (Basel, Switzerland) [Molecules] 2020 Sep 29; Vol. 25 (19). Date of Electronic Publication: 2020 Sep 29.
Typ publikacji:
Journal Article
MeSH Terms:
Theranostic Nanomedicine*
Curcumin/*therapeutic use
Naphthoquinones/*therapeutic use
Ovarian Neoplasms/*drug therapy
Animals ; Cell Line, Tumor ; Cell Shape/drug effects ; Cell Survival/drug effects ; Curcumin/chemistry ; Curcumin/pharmacology ; Female ; Fibroblasts/cytology ; Fibroblasts/drug effects ; Humans ; Hydrogen-Ion Concentration ; Inhibitory Concentration 50 ; Mice ; NIH 3T3 Cells ; Naphthoquinones/chemistry ; Naphthoquinones/pharmacology ; Ovarian Neoplasms/pathology ; Proton Magnetic Resonance Spectroscopy ; Spectrometry, Fluorescence
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Naphthoquinone-Based Meroterpenoids from Marine-Derived Streptomyces sp. B9173.
Autorzy:
Shen X; State Key Laboratory of Microbial Metabolism, and Joint International Research Laboratory on Metabolic & Developmental Sciences, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University; 800 Dongchuan Rd, Shanghai 200240, China.
Wang X; State Key Laboratory of Microbial Metabolism, and Joint International Research Laboratory on Metabolic & Developmental Sciences, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University; 800 Dongchuan Rd, Shanghai 200240, China.
Huang T; State Key Laboratory of Microbial Metabolism, and Joint International Research Laboratory on Metabolic & Developmental Sciences, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University; 800 Dongchuan Rd, Shanghai 200240, China.
Deng Z; State Key Laboratory of Microbial Metabolism, and Joint International Research Laboratory on Metabolic & Developmental Sciences, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University; 800 Dongchuan Rd, Shanghai 200240, China.
Lin S; State Key Laboratory of Microbial Metabolism, and Joint International Research Laboratory on Metabolic & Developmental Sciences, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University; 800 Dongchuan Rd, Shanghai 200240, China.
Pokaż więcej
Źródło:
Biomolecules [Biomolecules] 2020 Aug 15; Vol. 10 (8). Date of Electronic Publication: 2020 Aug 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Naphthoquinones/*isolation & purification
Naphthoquinones/*pharmacology
Streptomyces/*chemistry
Terpenes/*isolation & purification
Terpenes/*pharmacology
A549 Cells ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/isolation & purification ; Anti-Bacterial Agents/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/isolation & purification ; Antineoplastic Agents/pharmacology ; Aquatic Organisms/chemistry ; Aquatic Organisms/isolation & purification ; Biological Products/chemistry ; Biological Products/isolation & purification ; Biological Products/pharmacology ; Biosynthetic Pathways ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; HeLa Cells ; Humans ; Microbial Sensitivity Tests ; Molecular Structure ; Naphthoquinones/chemistry ; Terpenes/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 61-80 z 2845

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies