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Wyświetlanie 1-20 z 4336
Tytuł:
High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response.
Autorzy:
Gao H; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.
Korn JM; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.
Ferretti S; Oncology Disease Area, Novartis Institutes for Biomedical Research, Basel, Switzerland.
Monahan JE; Department of Oncology Translational Medicine, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.
Wang Y; China Novartis Institutes for Biomedical Research, Shanghai, China.
Singh M; Oncology Disease Area, Novartis Institutes for Biomedical Research, Emeryville, California, USA.
Zhang C; China Novartis Institutes for Biomedical Research, Shanghai, China.
Schnell C; Oncology Disease Area, Novartis Institutes for Biomedical Research, Basel, Switzerland.
Yang G; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.
Zhang Y; China Novartis Institutes for Biomedical Research, Shanghai, China.
Balbin OA; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.
Barbe S; Oncology Disease Area, Novartis Institutes for Biomedical Research, Basel, Switzerland.
Cai H; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.
Casey F; Oncology Disease Area, Novartis Institutes for Biomedical Research, Emeryville, California, USA.
Chatterjee S; Oncology Disease Area, Novartis Institutes for Biomedical Research, Emeryville, California, USA.
Chiang DY; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.
Chuai S; China Novartis Institutes for Biomedical Research, Shanghai, China.
Cogan SM; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.
Collins SD; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.
Dammassa E; Oncology Disease Area, Novartis Institutes for Biomedical Research, Basel, Switzerland.
Ebel N; Oncology Disease Area, Novartis Institutes for Biomedical Research, Basel, Switzerland.
Embry M; Oncology Disease Area, Novartis Institutes for Biomedical Research, Emeryville, California, USA.
Green J; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.
Kauffmann A; Oncology Disease Area, Novartis Institutes for Biomedical Research, Basel, Switzerland.
Kowal C; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.
Leary RJ; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.
Lehar J; Department of Oncology Translational Medicine, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.
Liang Y; China Novartis Institutes for Biomedical Research, Shanghai, China.
Loo A; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.
Lorenzana E; Oncology Disease Area, Novartis Institutes for Biomedical Research, Emeryville, California, USA.
Robert McDonald E 3rd; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.
McLaughlin ME; Department of Oncology Translational Medicine, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.
Merkin J; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.
Meyer R; Department of Oncology Translational Medicine, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.
Naylor TL; Department of Oncology Translational Medicine, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.
Patawaran M; Oncology Disease Area, Novartis Institutes for Biomedical Research, Emeryville, California, USA.
Reddy A; Department of Oncology Translational Medicine, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.
Röelli C; Oncology Disease Area, Novartis Institutes for Biomedical Research, Basel, Switzerland.
Ruddy DA; Department of Oncology Translational Medicine, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.
Salangsang F; Oncology Disease Area, Novartis Institutes for Biomedical Research, Emeryville, California, USA.
Santacroce F; Oncology Disease Area, Novartis Institutes for Biomedical Research, Basel, Switzerland.
Singh AP; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.
Tang Y; Oncology Disease Area, Novartis Institutes for Biomedical Research, Emeryville, California, USA.
Tinetto W; Oncology Disease Area, Novartis Institutes for Biomedical Research, Basel, Switzerland.
Tobler S; Oncology Disease Area, Novartis Institutes for Biomedical Research, Basel, Switzerland.
Velazquez R; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.
Venkatesan K; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.
Von Arx F; Oncology Disease Area, Novartis Institutes for Biomedical Research, Basel, Switzerland.
Wang HQ; Department of Oncology Translational Medicine, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.
Wang Z; China Novartis Institutes for Biomedical Research, Shanghai, China.
Wiesmann M; Oncology Disease Area, Novartis Institutes for Biomedical Research, Basel, Switzerland.
Wyss D; Oncology Disease Area, Novartis Institutes for Biomedical Research, Basel, Switzerland.
Xu F; China Novartis Institutes for Biomedical Research, Shanghai, China.
Bitter H; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.
Atadja P; China Novartis Institutes for Biomedical Research, Shanghai, China.
Lees E; Oncology Disease Area, Novartis Institutes for Biomedical Research, Emeryville, California, USA.
Hofmann F; Oncology Disease Area, Novartis Institutes for Biomedical Research, Basel, Switzerland.
Li E; China Novartis Institutes for Biomedical Research, Shanghai, China.
Keen N; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.
Cozens R; Oncology Disease Area, Novartis Institutes for Biomedical Research, Basel, Switzerland.
Jensen MR; Oncology Disease Area, Novartis Institutes for Biomedical Research, Basel, Switzerland.
Pryer NK; Oncology Disease Area, Novartis Institutes for Biomedical Research, Emeryville, California, USA.
Williams JA; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.
Sellers WR; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.
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Źródło:
Nature medicine [Nat Med] 2015 Nov; Vol. 21 (11), pp. 1318-25. Date of Electronic Publication: 2015 Oct 19.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*therapeutic use
High-Throughput Screening Assays/*methods
Neoplasms/*drug therapy
Xenograft Model Antitumor Assays/*methods
Animals ; Breast Neoplasms/drug therapy ; Carcinoma/drug therapy ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Pancreatic Ductal/drug therapy ; Colorectal Neoplasms/drug therapy ; Disease Models, Animal ; Female ; Humans ; Lung Neoplasms/drug therapy ; Melanoma/drug therapy ; Mice ; Neoplasm Transplantation ; Pancreatic Neoplasms/drug therapy ; Reproducibility of Results ; Skin Neoplasms/drug therapy ; Stomach Neoplasms/drug therapy
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The emerging role of lncRNAs in cancer.
Autorzy:
Huarte M; Center for Applied Medical Research (CIMA), Department of Gene Therapy and Regulation of Gene Expression, University of Navarra, Pamplona, Spain.
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Źródło:
Nature medicine [Nat Med] 2015 Nov; Vol. 21 (11), pp. 1253-61.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Biomarkers, Tumor/*genetics
Gene Expression Regulation, Neoplastic/*genetics
Neoplasms/*genetics
RNA, Long Noncoding/*genetics
Animals ; Disease Progression ; Gene Knockdown Techniques ; High-Throughput Nucleotide Sequencing ; Humans ; Neoplasms/diagnosis ; Neoplasms/therapy ; Transcriptome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Hair follicle-derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma.
Autorzy:
Adachi T; Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.
Kobayashi T; Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.; Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Sugihara E; Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan.
Yamada T; Department of Pathology, Keio University School of Medicine, Tokyo, Japan.
Ikuta K; Laboratory of Biological Protection, Department of Biological Responses, Institute for Virus Research, Kyoto University, Kyoto, Japan.
Pittaluga S; Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Saya H; Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan.
Amagai M; Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.
Nagao K; Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.; Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
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Źródło:
Nature medicine [Nat Med] 2015 Nov; Vol. 21 (11), pp. 1272-9. Date of Electronic Publication: 2015 Oct 19.
Typ publikacji:
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms:
CD4-Positive T-Lymphocytes/*immunology
CD8-Positive T-Lymphocytes/*immunology
Epidermis/*immunology
Hair Follicle/*immunology
Interleukin-15/*immunology
Interleukin-7/*immunology
Keratinocytes/*immunology
Lymphoma, T-Cell, Cutaneous/*immunology
Skin Neoplasms/*immunology
Animals ; Cell Movement ; Hair Follicle/cytology ; Haptens ; Homeostasis ; Humans ; Langerhans Cells/immunology ; Mice ; Skin/immunology ; T-Lymphocyte Subsets/immunology ; T-Lymphocytes/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Viral variants that initiate and drive maturation of V1V2-directed HIV-1 broadly neutralizing antibodies.
Autorzy:
Bhiman JN; Centre for HIV and STIs, National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.; Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Anthony C; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Doria-Rose NA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Karimanzira O; Centre for HIV and STIs, National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.
Schramm CA; Department of Biochemistry and Systems Biology, Columbia University, New York, New York, USA.
Khoza T; Centre for HIV and STIs, National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.
Kitchin D; Centre for HIV and STIs, National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.
Botha G; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Gorman J; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Garrett NJ; Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu Natal, Durban, South Africa.
Abdool Karim SS; Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu Natal, Durban, South Africa.
Shapiro L; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.; Department of Biochemistry and Systems Biology, Columbia University, New York, New York, USA.
Williamson C; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.; Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu Natal, Durban, South Africa.; National Health Laboratory Services, Johannesburg, South Africa.
Kwong PD; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Mascola JR; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Morris L; Centre for HIV and STIs, National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.; Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu Natal, Durban, South Africa.
Moore PL; Centre for HIV and STIs, National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.; Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu Natal, Durban, South Africa.
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Źródło:
Nature medicine [Nat Med] 2015 Nov; Vol. 21 (11), pp. 1332-6. Date of Electronic Publication: 2015 Oct 12.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Antibodies, Neutralizing/*immunology
Epitopes/*immunology
HIV Antibodies/*immunology
HIV Envelope Protein gp120/*genetics
HIV Infections/*immunology
HIV-1/*genetics
Peptide Fragments/*genetics
RNA, Viral/*genetics
Superinfection/*immunology
AIDS Vaccines/immunology ; Antigenic Variation ; Female ; Genetic Variation ; HIV-1/immunology ; High-Throughput Nucleotide Sequencing ; Humans ; Neutralization Tests ; Sequence Analysis, RNA
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade.
Autorzy:
Xu ZZ; Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA.; Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, USA.
Kim YH; Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA.; Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, USA.; Pain Cognitive Function Research Center, Dental Research Institute and Department of Neurobiology and Physiology, School of Dentistry, Seoul National University, Seoul, Republic of Korea.
Bang S; Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA.; Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, USA.
Zhang Y; Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, USA.
Berta T; Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA.; Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, USA.
Wang F; Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, USA.
Oh SB; Pain Cognitive Function Research Center, Dental Research Institute and Department of Neurobiology and Physiology, School of Dentistry, Seoul National University, Seoul, Republic of Korea.; Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea.
Ji RR; Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA.; Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, USA.
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Źródło:
Nature medicine [Nat Med] 2015 Nov; Vol. 21 (11), pp. 1326-31. Date of Electronic Publication: 2015 Oct 19.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Anesthetics, Local/*pharmacology
Flagellin/*pharmacology
Ganglia, Spinal/*drug effects
Hyperalgesia/*genetics
Lidocaine/*analogs & derivatives
Nerve Fibers, Myelinated/*drug effects
Neuralgia/*genetics
Neurons/*drug effects
Toll-Like Receptor 5/*genetics
Adult ; Aged ; Animals ; Antineoplastic Agents/toxicity ; Capsaicin/pharmacology ; Diabetic Neuropathies/complications ; Female ; Ganglia, Spinal/cytology ; Ganglia, Spinal/metabolism ; Humans ; Hyperalgesia/etiology ; Hyperalgesia/metabolism ; Lidocaine/pharmacology ; Male ; Mice ; Mice, Knockout ; Middle Aged ; Nerve Fibers, Myelinated/metabolism ; Nerve Fibers, Unmyelinated/drug effects ; Neuralgia/etiology ; Neuralgia/metabolism ; Neurofilament Proteins/metabolism ; Neurons/cytology ; Neurons/metabolism ; Paclitaxel/toxicity ; Peripheral Nerve Injuries/complications ; Sensory System Agents/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells.
Autorzy:
Gur-Cohen S; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
Itkin T; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
Chakrabarty S; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.
Graf C; Center for Thrombosis and Hemostasis, Johannes Gutenberg-University Medical Center, Mainz, Germany.
Kollet O; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
Ludin A; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
Golan K; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
Kalinkovich A; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
Ledergor G; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.; Internal Medicine Department T, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.
Wong E; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.
Niemeyer E; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.; Universitätsklinikum Schleswig-Holstein Campus Luebeck, Klinik für Strahlentherapie, Universitaet zu Luebeck, Germany.
Porat Z; Flow Cytometry Unit, Department of Biological Services, Weizmann Institute of Science, Rehovot, Israel.
Erez A; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.
Sagi I; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.
Esmon CT; Coagulation Biology Laboratory, Oklahoma Medical Research Foundation and Departments of Pathology and Biochemistry &Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Ruf W; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.; Center for Thrombosis and Hemostasis, Johannes Gutenberg-University Medical Center, Mainz, Germany.
Lapidot T; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
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Źródło:
Nature medicine [Nat Med] 2015 Nov; Vol. 21 (11), pp. 1307-17. Date of Electronic Publication: 2015 Oct 12.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Hematopoietic Stem Cells/*metabolism
Nitric Oxide/*metabolism
Protein C/*metabolism
Receptor, PAR-1/*metabolism
Receptors, Cell Surface/*metabolism
Thrombin/*metabolism
ADAM Proteins/metabolism ; ADAM17 Protein ; Animals ; Bone Marrow/metabolism ; Cell Adhesion ; Cell Movement ; Chemokine CXCL12/metabolism ; Endothelial Protein C Receptor ; Hematopoietic Stem Cells/cytology ; Integrin alpha4beta1/metabolism ; Mice ; Mice, Inbred C57BL ; Receptors, CXCR4/metabolism ; Signal Transduction ; cdc42 GTP-Binding Protein/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Selective inhibition of the p38 alternative activation pathway in infiltrating T cells inhibits pancreatic cancer progression.
Autorzy:
Alam MS; Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Gaida MM; Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Bergmann F; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Lasitschka F; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Giese T; Institute of Immunology, University of Heidelberg, Heidelberg, Germany.
Giese NA; Department of Surgery, University Hospital Heidelberg, Heidelberg, Germany.
Hackert T; Department of Surgery, University Hospital Heidelberg, Heidelberg, Germany.
Hinz U; Department of Surgery, University Hospital Heidelberg, Heidelberg, Germany.
Hussain SP; Pancreatic Cancer Unit, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Kozlov SV; Cancer and Developmental Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA.
Ashwell JD; Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
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Źródło:
Nature medicine [Nat Med] 2015 Nov; Vol. 21 (11), pp. 1337-43. Date of Electronic Publication: 2015 Oct 19.
Typ publikacji:
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma, Pancreatic Ductal/*immunology
Cytokines/*immunology
Lymphocytes, Tumor-Infiltrating/*immunology
Pancreatic Neoplasms/*immunology
Receptors, Antigen, T-Cell/*immunology
T-Lymphocytes/*immunology
p38 Mitogen-Activated Protein Kinases/*immunology
Animals ; CD4-Positive T-Lymphocytes ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/metabolism ; Cell Line, Tumor ; Cytokines/metabolism ; Disease Progression ; Humans ; Interleukin-10/immunology ; Interleukin-10/metabolism ; Interleukin-17/immunology ; Interleukin-17/metabolism ; Lymphocytes, Tumor-Infiltrating/metabolism ; MAP Kinase Signaling System/genetics ; MAP Kinase Signaling System/immunology ; Mice ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/metabolism ; Phosphorylation ; Receptors, Antigen, T-Cell/metabolism ; T-Lymphocytes/metabolism ; Tumor Necrosis Factor-alpha/immunology ; Tumor Necrosis Factor-alpha/metabolism ; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors ; p38 Mitogen-Activated Protein Kinases/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels.
Autorzy:
Goedeke L; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, USA.; Integrative Cell Signaling and Neurobiology of Metabolism Program, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.; Department of Medicine, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA.; Department of Cell Biology, New York University School of Medicine, New York, New York, USA.
Rotllan N; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, USA.; Integrative Cell Signaling and Neurobiology of Metabolism Program, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Canfrán-Duque A; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, USA.; Integrative Cell Signaling and Neurobiology of Metabolism Program, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Aranda JF; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, USA.; Integrative Cell Signaling and Neurobiology of Metabolism Program, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.; Department of Medicine, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA.
Ramírez CM; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, USA.; Integrative Cell Signaling and Neurobiology of Metabolism Program, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Araldi E; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, USA.; Integrative Cell Signaling and Neurobiology of Metabolism Program, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.; Department of Medicine, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA.; Department of Cell Biology, New York University School of Medicine, New York, New York, USA.
Lin CS; Department of Medicine, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA.; Department of Cell Biology, New York University School of Medicine, New York, New York, USA.
Anderson NN; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Wagschal A; Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts, USA.; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
de Cabo R; Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
Horton JD; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Lasunción MA; Servicio de Bioquímica-Investigación, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain.; Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición, Madrid, Spain.
Näär AM; Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts, USA.; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
Suárez Y; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, USA.; Integrative Cell Signaling and Neurobiology of Metabolism Program, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.; Department of Medicine, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA.; Department of Cell Biology, New York University School of Medicine, New York, New York, USA.
Fernández-Hernando C; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, USA.; Integrative Cell Signaling and Neurobiology of Metabolism Program, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.; Department of Medicine, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA.; Department of Cell Biology, New York University School of Medicine, New York, New York, USA.
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Źródło:
Nature medicine [Nat Med] 2015 Nov; Vol. 21 (11), pp. 1280-9. Date of Electronic Publication: 2015 Oct 05.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
ATP Binding Cassette Transporter 1/*genetics
Cholesterol, HDL/*metabolism
Cholesterol, LDL/*metabolism
Hepatocytes/*metabolism
Liver/*metabolism
MicroRNAs/*genetics
Receptors, LDL/*genetics
ATP Binding Cassette Transporter 1/metabolism ; Animals ; Gene Expression Regulation ; Hep G2 Cells ; High-Throughput Screening Assays ; Humans ; Mice ; MicroRNAs/metabolism ; RNA Processing, Post-Transcriptional ; Receptors, LDL/metabolism ; Signal Transduction ; Sterol Regulatory Element Binding Protein 1/genetics ; Sterol Regulatory Element Binding Protein 1/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Loss of BAP1 function leads to EZH2-dependent transformation.
Autorzy:
LaFave LM; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.; Gerstner Sloan Kettering School of Biomedical Sciences, New York, New York, USA.
Béguelin W; Department of Hematology/Oncology, Weill Cornell Medical College, New York, New York, USA.
Koche R; The Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, New York, USA.; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Teater M; Department of Hematology/Oncology, Weill Cornell Medical College, New York, New York, USA.
Spitzer B; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Chramiec A; The Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Papalexi E; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Keller MD; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Hricik T; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Konstantinoff K; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Micol JB; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Durham B; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Knutson SK; Epizyme, Inc., Cambridge, Massachusetts, USA.
Campbell JE; Epizyme, Inc., Cambridge, Massachusetts, USA.
Blum G; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Tri-Institutional Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Shi X; Chemical Synthesis Core, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Doud EH; Proteomics Center of Excellence, Northwestern University, Evanston, Illinois, USA.
Krivtsov AV; The Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Chung YR; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Khodos I; Anti-Tumor Assessment Core, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
de Stanchina E; Anti-Tumor Assessment Core, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Ouerfelli O; Chemical Synthesis Core, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Adusumilli PS; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Thomas PM; Proteomics Center of Excellence, Northwestern University, Evanston, Illinois, USA.
Kelleher NL; Proteomics Center of Excellence, Northwestern University, Evanston, Illinois, USA.
Luo M; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Keilhack H; Epizyme, Inc., Cambridge, Massachusetts, USA.
Abdel-Wahab O; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Melnick A; Department of Hematology/Oncology, Weill Cornell Medical College, New York, New York, USA.
Armstrong SA; The Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, New York, USA.; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Levine RL; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.; The Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, New York, USA.; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
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Źródło:
Nature medicine [Nat Med] 2015 Nov; Vol. 21 (11), pp. 1344-9. Date of Electronic Publication: 2015 Oct 05.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Gene Expression Regulation, Neoplastic*
Histones/*metabolism
Tumor Suppressor Proteins/*genetics
Ubiquitin Thiolesterase/*genetics
Animals ; Blotting, Western ; Cell Line, Tumor ; Chromatin Immunoprecipitation ; Enhancer of Zeste Homolog 2 Protein ; Epigenesis, Genetic ; Gene Knockout Techniques ; HEK293 Cells ; Histone Code ; Histone-Lysine N-Methyltransferase/genetics ; Histone-Lysine N-Methyltransferase/metabolism ; Humans ; Immunoprecipitation ; Leukemia/genetics ; Mesothelioma/genetics ; Methylation ; Mice ; Polycomb Repressive Complex 2/genetics ; Polycomb Repressive Complex 2/metabolism ; Real-Time Polymerase Chain Reaction ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Tumor Suppressor Proteins/metabolism ; Ubiquitin Thiolesterase/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Cardiac RKIP induces a beneficial β-adrenoceptor-dependent positive inotropy.
Autorzy:
Schmid E; Department of Pharmacology, Institute of Pharmacology and Toxicology, Würzburg, Germany.
Neef S; Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.
Berlin C; Department of Pharmacology, Institute of Pharmacology and Toxicology, Würzburg, Germany.
Tomasovic A; Department of Pharmacology, Institute of Pharmacology and Toxicology, Würzburg, Germany.
Kahlert K; Department of Pharmacology, Institute of Pharmacology and Toxicology, Würzburg, Germany.
Nordbeck P; Comprehensive Heart Failure Center, Würzburg, Germany.; Department of Internal Medicine I, University of Würzburg, Würzburg, Germany.
Deiss K; Department of Pharmacology, Institute of Pharmacology and Toxicology, Würzburg, Germany.
Denzinger S; Department of Pharmacology, Institute of Pharmacology and Toxicology, Würzburg, Germany.
Herrmann S; Comprehensive Heart Failure Center, Würzburg, Germany.; Department of Internal Medicine I, University of Würzburg, Würzburg, Germany.
Wettwer E; Department of Pharmacology and Toxicology, Medical Faculty Gustav Carus, Dresden University of Technology, Dresden, Germany.
Weidendorfer M; Department of Pharmacology, Institute of Pharmacology and Toxicology, Würzburg, Germany.
Becker D; Department of Pharmacology, Institute of Pharmacology and Toxicology, Würzburg, Germany.
Schäfer F; Department of Pharmacology, Institute of Pharmacology and Toxicology, Würzburg, Germany.
Wagner N; Institute of Anatomy and Cell Biology, Würzburg, Germany.
Ergün S; Institute of Anatomy and Cell Biology, Würzburg, Germany.
Schmitt JP; Department of Pharmacology, Institute of Pharmacology and Toxicology, Würzburg, Germany.
Katus HA; Department of Internal Medicine III, Heidelberg University Hospital, Heidelberg, Germany.; German Centre for Cardiovascular Research, Heidelberg University Hospital, Heidelberg, Germany.
Weidemann F; Comprehensive Heart Failure Center, Würzburg, Germany.; Department of Internal Medicine I, University of Würzburg, Würzburg, Germany.
Ravens U; Department of Pharmacology and Toxicology, Medical Faculty Gustav Carus, Dresden University of Technology, Dresden, Germany.
Maack C; Clinic for Internal Medicine III, Saarland University Hospital, Homburg, Germany.
Hein L; Institute of Experimental and Clinical Pharmacology and Toxicology, Freiburg, Germany.; Centre for Biological Signalling Studies (BIOSS), University of Freiburg, Freiburg, Germany.
Ertl G; Comprehensive Heart Failure Center, Würzburg, Germany.; Department of Internal Medicine I, University of Würzburg, Würzburg, Germany.
Müller OJ; Department of Internal Medicine III, Heidelberg University Hospital, Heidelberg, Germany.; German Centre for Cardiovascular Research, Heidelberg University Hospital, Heidelberg, Germany.
Maier LS; Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.
Lohse MJ; Department of Pharmacology, Institute of Pharmacology and Toxicology, Würzburg, Germany.; Comprehensive Heart Failure Center, Würzburg, Germany.
Lorenz K; Department of Pharmacology, Institute of Pharmacology and Toxicology, Würzburg, Germany.; Comprehensive Heart Failure Center, Würzburg, Germany.
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Źródło:
Nature medicine [Nat Med] 2015 Nov; Vol. 21 (11), pp. 1298-306. Date of Electronic Publication: 2015 Oct 19.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Heart Failure/*genetics
Myocardial Contraction/*genetics
Myocytes, Cardiac/*metabolism
Phosphatidylethanolamine Binding Protein/*genetics
Receptors, Adrenergic, beta-1/*metabolism
Animals ; Chromatin Immunoprecipitation ; Electrophoresis, Gel, Two-Dimensional ; Gene Knock-In Techniques ; Gene Knockdown Techniques ; Gene Transfer Techniques ; Heart Failure/metabolism ; Humans ; Immunohistochemistry ; In Situ Nick-End Labeling ; Mice ; Mice, Transgenic ; Phosphatidylethanolamine Binding Protein/metabolism ; Reverse Transcriptase Polymerase Chain Reaction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Excess TGF-β mediates muscle weakness associated with bone metastases in mice.
Autorzy:
Waning DL; Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Mohammad KS; Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Reiken S; Department of Physiology and Cellular Biophysics, Helen and Clyde Wu Center for Molecular Cardiology, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Xie W; Department of Physiology and Cellular Biophysics, Helen and Clyde Wu Center for Molecular Cardiology, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Andersson DC; Department of Physiology and Cellular Biophysics, Helen and Clyde Wu Center for Molecular Cardiology, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
John S; Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Chiechi A; Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Wright LE; Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Umanskaya A; Department of Physiology and Cellular Biophysics, Helen and Clyde Wu Center for Molecular Cardiology, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Niewolna M; Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Trivedi T; Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Charkhzarrin S; Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Khatiwada P; Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Wronska A; Department of Physiology and Cellular Biophysics, Helen and Clyde Wu Center for Molecular Cardiology, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Haynes A; Department of Physiology and Cellular Biophysics, Helen and Clyde Wu Center for Molecular Cardiology, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Benassi MS; Laboratory of Experimental Oncology, Instituto Ortopedico Rizzoli, Bologna, Italy.
Witzmann FA; Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Zhen G; Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Wang X; Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Cao X; Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Roodman GD; Department of Medicine, Division of Hematology/Oncology, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Richard L. Roudebush VA Medical Center, Indianapolis, Indiana, USA.
Marks AR; Department of Physiology and Cellular Biophysics, Helen and Clyde Wu Center for Molecular Cardiology, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Guise TA; Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
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Źródło:
Nature medicine [Nat Med] 2015 Nov; Vol. 21 (11), pp. 1262-1271. Date of Electronic Publication: 2015 Oct 12.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Bone Neoplasms/*metabolism
Calcium/*metabolism
Muscle Weakness/*metabolism
Muscle, Skeletal/*metabolism
Neoplasms/*metabolism
Osteolysis/*metabolism
Ryanodine Receptor Calcium Release Channel/*metabolism
Transforming Growth Factor beta/*metabolism
Absorptiometry, Photon ; Animals ; Bone Neoplasms/diagnostic imaging ; Bone Neoplasms/secondary ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Calcium Signaling ; Camurati-Engelmann Syndrome/metabolism ; Cell Line, Tumor ; Disease Models, Animal ; Female ; Humans ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; MCF-7 Cells ; Male ; Mice ; Mice, Nude ; Mice, SCID ; Multiple Myeloma/metabolism ; Multiple Myeloma/pathology ; Muscle Contraction ; Muscle Proteins/metabolism ; Muscle Strength ; Muscle Weakness/etiology ; NADPH Oxidase 4 ; NADPH Oxidases/genetics ; NADPH Oxidases/metabolism ; Neoplasms/complications ; Neoplasms/pathology ; Osteolysis/diagnostic imaging ; Osteolysis/etiology ; Oxidation-Reduction ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; Up-Regulation ; X-Ray Microtomography
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids.
Autorzy:
Huang L; Princess Margaret Cancer Center, University Health Network (UHN), University of Toronto, Toronto, Ontario, Canada.
Holtzinger A; Princess Margaret Cancer Center, University Health Network (UHN), University of Toronto, Toronto, Ontario, Canada.; McEwen Center for Regenerative Medicine, University Health Network, Toronto, Ontario, Canada.
Jagan I; Princess Margaret Cancer Center, University Health Network (UHN), University of Toronto, Toronto, Ontario, Canada.
BeGora M; Princess Margaret Cancer Center, University Health Network (UHN), University of Toronto, Toronto, Ontario, Canada.
Lohse I; Princess Margaret Cancer Center, University Health Network (UHN), University of Toronto, Toronto, Ontario, Canada.
Ngai N; Princess Margaret Cancer Center, University Health Network (UHN), University of Toronto, Toronto, Ontario, Canada.
Nostro C; Princess Margaret Cancer Center, University Health Network (UHN), University of Toronto, Toronto, Ontario, Canada.; McEwen Center for Regenerative Medicine, University Health Network, Toronto, Ontario, Canada.
Wang R; Department of Physiology, Western University, London, Ontario, Canada.; Department of Pharmacology, Western University, London, Ontario, Canada.
Muthuswamy LB; Princess Margaret Cancer Center, University Health Network (UHN), University of Toronto, Toronto, Ontario, Canada.
Crawford HC; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan.; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
Arrowsmith C; Princess Margaret Cancer Center, University Health Network (UHN), University of Toronto, Toronto, Ontario, Canada.; Structural Genomics Consortium, Toronto, Ontario, Canada.
Kalloger SE; Division of Anatomic Pathology, Vancouver General Hospital, Vancouver, British Columbia, Canada.; Department of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada.; Pancreas Centre British Columbia, Vancouver, British Columbia, Canada.
Renouf DJ; Department of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada.; Pancreas Centre British Columbia, Vancouver, British Columbia, Canada.; Division of Medical Oncology, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.
Connor AA; Division of General Surgery, University of Toronto, Toronto, Ontario, Canada.
Cleary S; Division of General Surgery, University of Toronto, Toronto, Ontario, Canada.
Schaeffer DF; Division of Anatomic Pathology, Vancouver General Hospital, Vancouver, British Columbia, Canada.; Department of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada.; Pancreas Centre British Columbia, Vancouver, British Columbia, Canada.
Roehrl M; Princess Margaret Cancer Center, University Health Network (UHN), University of Toronto, Toronto, Ontario, Canada.
Tsao MS; Princess Margaret Cancer Center, University Health Network (UHN), University of Toronto, Toronto, Ontario, Canada.; Department of Pathology, University Health Network, Toronto, Ontario, Canada.
Gallinger S; Division of General Surgery, University of Toronto, Toronto, Ontario, Canada.
Keller G; Princess Margaret Cancer Center, University Health Network (UHN), University of Toronto, Toronto, Ontario, Canada.; McEwen Center for Regenerative Medicine, University Health Network, Toronto, Ontario, Canada.
Muthuswamy SK; Princess Margaret Cancer Center, University Health Network (UHN), University of Toronto, Toronto, Ontario, Canada.
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Źródło:
Nature medicine [Nat Med] 2015 Nov; Vol. 21 (11), pp. 1364-71. Date of Electronic Publication: 2015 Oct 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Pluripotent Stem Cells*
Antimetabolites, Antineoplastic/*pharmacology
Carcinoma, Pancreatic Ductal/*drug therapy
Deoxycytidine/*analogs & derivatives
Organoids/*drug effects
Pancreas/*drug effects
Pancreatic Neoplasms/*drug therapy
Animals ; Carcinoma, Pancreatic Ductal/genetics ; Deoxycytidine/pharmacology ; Drug Screening Assays, Antitumor/methods ; Humans ; Mice ; Models, Biological ; Mutation ; Organoids/pathology ; Organoids/ultrastructure ; Pancreas/pathology ; Pancreas/ultrastructure ; Pancreatic Neoplasms/genetics ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins p21(ras) ; SOX9 Transcription Factor/metabolism ; Tissue Culture Techniques ; Tumor Suppressor Protein p53/genetics ; ras Proteins/genetics ; Gemcitabine
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis.
Autorzy:
Wagschal A; Massachusetts General Hospital Center for Cancer Research, Charlestown, Massachusetts, USA.; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
Najafi-Shoushtari SH; Massachusetts General Hospital Center for Cancer Research, Charlestown, Massachusetts, USA.; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
Wang L; Massachusetts General Hospital Center for Cancer Research, Charlestown, Massachusetts, USA.; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
Goedeke L; Section of Comparative Medicine, Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA.
Sinha S; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
deLemos AS; Liver Center and Gastrointestinal Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Black JC; Massachusetts General Hospital Center for Cancer Research, Charlestown, Massachusetts, USA.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
Ramírez CM; Section of Comparative Medicine, Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA.
Li Y; Department of Medicine, Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Tewhey R; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA.; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, USA.
Hatoum I; Obesity, Metabolism and Nutrition Institute and Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Shah N; Systems Genomics and Bioinformatics Unit, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Lu Y; Systems Genomics and Bioinformatics Unit, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Kristo F; Massachusetts General Hospital Center for Cancer Research, Charlestown, Massachusetts, USA.
Psychogios N; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Vrbanac V; Harvard University Center for AIDS Research, Cambridge, Massachusetts USA.
Lu YC; Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, New York, USA.
Hla T; Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, New York, USA.
de Cabo R; Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
Tsang JS; Systems Genomics and Bioinformatics Unit, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Schadt E; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Sabeti PC; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA.; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, USA.
Kathiresan S; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA.; Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.
Cohen DE; Department of Medicine, Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Whetstine J; Massachusetts General Hospital Center for Cancer Research, Charlestown, Massachusetts, USA.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
Chung RT; Liver Center and Gastrointestinal Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
Fernández-Hernando C; Section of Comparative Medicine, Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA.
Kaplan LM; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.; Obesity, Metabolism and Nutrition Institute and Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Bernards A; Massachusetts General Hospital Center for Cancer Research, Charlestown, Massachusetts, USA.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.; Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.
Gerszten RE; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
Näär AM; Massachusetts General Hospital Center for Cancer Research, Charlestown, Massachusetts, USA.; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
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Źródło:
Nature medicine [Nat Med] 2015 Nov; Vol. 21 (11), pp. 1290-7. Date of Electronic Publication: 2015 Oct 26.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Diet, High-Fat*
ATP Binding Cassette Transporter 1/*metabolism
Cholesterol, HDL/*metabolism
Cholesterol, LDL/*metabolism
Dyslipidemias/*genetics
MicroRNAs/*genetics
Receptors, LDL/*metabolism
Triglycerides/*metabolism
Animals ; Apolipoproteins E/genetics ; Cholesterol/metabolism ; Genome-Wide Association Study ; Homeostasis/genetics ; Humans ; Lipoproteins/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Polymorphism, Single Nucleotide
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
CAUSEL: an epigenome- and genome-editing pipeline for establishing function of noncoding GWAS variants.
Autorzy:
Spisák S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Lawrenson K; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Fu Y; Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, Massachusetts, USA.; Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.; Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA.
Csabai I; Department of Physics of Complex Systems, Eötvös Loránd University, Budapest, Hungary.
Cottman RT; Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, Massachusetts, USA.; Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.; Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, Massachusetts, USA.
Seo JH; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Haiman C; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
Han Y; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Lenci R; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Li Q; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Medical College, Xiamen University, Xiamen, China.
Tisza V; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Computational Health Informatics Program (CHIP), Boston Children's Hospital, Boston, Massachusetts, USA.
Szállási Z; Computational Health Informatics Program (CHIP), Boston Children's Hospital, Boston, Massachusetts, USA.; Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark.; Second Department of Pathology, Semmelweis University, Budapest, Hungary.
Herbert ZT; Molecular Biology Core Facilities at Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Chabot M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Pomerantz M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Solymosi N; Department of Animal Hygiene, Szent István University, Budapest, Hungary.
Gayther SA; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.; The Eli and Edythe L. Broad Institute, Cambridge, Massachusetts, USA.
Joung JK; Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, Massachusetts, USA.; Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.; Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA.; Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, Massachusetts, USA.
Freedman ML; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; The Eli and Edythe L. Broad Institute, Cambridge, Massachusetts, USA.
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Corporate Authors:
GAME-ON/ELLIPSE Consortium
Źródło:
Nature medicine [Nat Med] 2015 Nov; Vol. 21 (11), pp. 1357-63. Date of Electronic Publication: 2015 Sep 23.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Chromosomes, Human, Pair 6/*genetics
Gene Expression Regulation, Neoplastic/*genetics
Prostatic Neoplasms/*genetics
RNA, Messenger/*metabolism
Transcription Factors/*genetics
Alleles ; Cell Line, Tumor ; Chromosome Mapping ; DNA-Binding Proteins/genetics ; Epigenomics ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Histone Code ; Histones/metabolism ; Homeodomain Proteins/genetics ; Humans ; Male ; Polymorphism, Single Nucleotide ; Regulatory Factor X Transcription Factors ; Reverse Transcriptase Polymerase Chain Reaction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A pathway to HIV-1 neutralization breadth.
Autorzy:
Smith SA; Yerkes National Primate Research Center, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA.
Derdeyn CA; Yerkes National Primate Research Center, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA.
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Źródło:
Nature medicine [Nat Med] 2015 Nov; Vol. 21 (11), pp. 1246-7.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
AIDS Vaccines/*immunology
Antibodies, Neutralizing/*immunology
B-Lymphocytes/*immunology
HIV Antibodies/*immunology
HIV-1/*immunology
High-Throughput Nucleotide Sequencing ; Humans ; Superinfection/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The consensus molecular subtypes of colorectal cancer.
Autorzy:
Guinney J; Sage Bionetworks, Seattle, Washington, USA.
Dienstmann R; Sage Bionetworks, Seattle, Washington, USA.; Vall d'Hebron Institute of Oncology (VHIO), Universitat Autònoma de Barcelona, Barcelona, Spain.
Wang X; Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM), Academic Medical Center (AMC), University of Amsterdam, Amsterdam, the Netherlands.; Department of Biomedical Sciences, City University of Hong Kong, Hong Kong.
de Reyniès A; Ligue Nationale Contre le Cancer, Paris, France.
Schlicker A; Netherlands Cancer Institute (NKI), Amsterdam, the Netherlands.
Soneson C; Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland.
Marisa L; Ligue Nationale Contre le Cancer, Paris, France.
Roepman P; Agendia NV, Amsterdam, the Netherlands.
Nyamundanda G; Institute of Cancer Research, London, UK.
Angelino P; Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland.
Bot BM; Sage Bionetworks, Seattle, Washington, USA.
Morris JS; The University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USA.
Simon IM; Agendia NV, Amsterdam, the Netherlands.
Gerster S; Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland.
Fessler E; Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM), Academic Medical Center (AMC), University of Amsterdam, Amsterdam, the Netherlands.
De Sousa E Melo F; Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM), Academic Medical Center (AMC), University of Amsterdam, Amsterdam, the Netherlands.
Missiaglia E; Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland.
Ramay H; Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland.
Barras D; Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland.
Homicsko K; École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Maru D; The University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USA.
Manyam GC; The University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USA.
Broom B; The University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USA.
Boige V; Gustave Roussy, Villejuif, France.
Perez-Villamil B; Laboratorio de Genomica y Microarrays, Instituto de Investigación Sanitaria San Carlos, Hospital Clinico San Carlos, Madrid, Spain.
Laderas T; Sage Bionetworks, Seattle, Washington, USA.
Salazar R; Institut Catala d'Oncologia, L'Institut d'Investigació Biomèdica de Bellvitge, Barcelona, Spain.
Gray JW; Biomedical Engineering, Oregon Health Sciences University, Portland, Oregon, USA.
Hanahan D; École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Tabernero J; Vall d'Hebron Institute of Oncology (VHIO), Universitat Autònoma de Barcelona, Barcelona, Spain.
Bernards R; Netherlands Cancer Institute (NKI), Amsterdam, the Netherlands.
Friend SH; Sage Bionetworks, Seattle, Washington, USA.
Laurent-Puig P; Université Paris Descartes, Paris, France.; Department of Biology, Hôpital Européen Georges-Pompidou, Assistance Publique - Hôpitaux de Paris, Paris, France.
Medema JP; Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM), Academic Medical Center (AMC), University of Amsterdam, Amsterdam, the Netherlands.
Sadanandam A; Institute of Cancer Research, London, UK.
Wessels L; Netherlands Cancer Institute (NKI), Amsterdam, the Netherlands.
Delorenzi M; Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland.; Ludwig Center for Cancer Research, University of Lausanne, Lausanne, Switzerland.; Department of Oncology, University of Lausanne, Lausanne, Switzerland.
Kopetz S; The University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USA.
Vermeulen L; Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM), Academic Medical Center (AMC), University of Amsterdam, Amsterdam, the Netherlands.
Tejpar S; Universitair ziekenhuis Leuven, Leuven, Belgium.
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Źródło:
Nature medicine [Nat Med] 2015 Nov; Vol. 21 (11), pp. 1350-6. Date of Electronic Publication: 2015 Oct 12.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation, Neoplastic*
Carcinoma/*genetics
Colorectal Neoplasms/*genetics
Neovascularization, Pathologic/*genetics
Transforming Growth Factor beta/*genetics
Carcinoma/classification ; Carcinoma/pathology ; Colorectal Neoplasms/classification ; Colorectal Neoplasms/pathology ; Consensus ; CpG Islands ; DNA Copy Number Variations/genetics ; DNA Methylation ; Gene Expression Profiling ; Genes, myc/genetics ; Humans ; Information Dissemination ; Microsatellite Instability ; Mutation/genetics ; Neovascularization, Pathologic/pathology ; Phenotype ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins B-raf/genetics ; Proto-Oncogene Proteins p21(ras) ; Wnt Signaling Pathway/genetics ; ras Proteins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Natural and therapy-induced immunosurveillance in breast cancer.
Autorzy:
Kroemer G; Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, Paris, France.; INSERM, U1138, Paris, France.; Université Paris Descartes/Paris V, Sorbonne, Paris, France.; Université Pierre et Marie Curie/Paris VI, Paris, France.; Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Institute, Villejuif, France.; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France.; Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden.
Senovilla L; Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, Paris, France.; INSERM, U1138, Paris, France.; Université Paris Descartes/Paris V, Sorbonne, Paris, France.; Université Pierre et Marie Curie/Paris VI, Paris, France.; Gustave Roussy Comprehensive Cancer Institute, Villejuif, France.
Galluzzi L; Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, Paris, France.; INSERM, U1138, Paris, France.; Université Paris Descartes/Paris V, Sorbonne, Paris, France.; Université Pierre et Marie Curie/Paris VI, Paris, France.; Gustave Roussy Comprehensive Cancer Institute, Villejuif, France.
André F; Gustave Roussy Comprehensive Cancer Institute, Villejuif, France.; University of Paris Sud/Paris XI, Le Kremlin-Bicêtre, France.
Zitvogel L; Gustave Roussy Comprehensive Cancer Institute, Villejuif, France.; University of Paris Sud/Paris XI, Le Kremlin-Bicêtre, France.; INSERM, U1015, Villejuif, France.; Center of Clinical Investigations in Biotherapies of Cancer 507 (CICBT 507), Villejuif, France.
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Źródło:
Nature medicine [Nat Med] 2015 Oct; Vol. 21 (10), pp. 1128-38.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Monitoring, Immunologic*
Breast Neoplasms/*immunology
Breast Neoplasms/diagnosis ; Breast Neoplasms/therapy ; Humans ; Immunotherapy ; Receptor, ErbB-2/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis.
Autorzy:
Zhang J; Institute for Cancer Genetics, Columbia University, New York, New York, USA.
Dominguez-Sola D; Institute for Cancer Genetics, Columbia University, New York, New York, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Hussein S; Institute for Cancer Genetics, Columbia University, New York, New York, USA.
Lee JE; Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Holmes AB; Institute for Cancer Genetics, Columbia University, New York, New York, USA.
Bansal M; Department of Systems Biology, Columbia University, New York, New York, USA.
Vlasevska S; Institute for Cancer Genetics, Columbia University, New York, New York, USA.
Mo T; Institute for Cancer Genetics, Columbia University, New York, New York, USA.
Tang H; Institute for Cancer Genetics, Columbia University, New York, New York, USA.
Basso K; Institute for Cancer Genetics, Columbia University, New York, New York, USA.; Department of Pathology and Cell Biology, Columbia University, New York, New York, USA.
Ge K; Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Dalla-Favera R; Institute for Cancer Genetics, Columbia University, New York, New York, USA.; Department of Pathology and Cell Biology, Columbia University, New York, New York, USA.; Department of Genetics &Development, Columbia University, New York, New York, USA.; Department of Microbiology &Immunology, Columbia University, New York, New York, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York, USA.
Pasqualucci L; Institute for Cancer Genetics, Columbia University, New York, New York, USA.; Department of Pathology and Cell Biology, Columbia University, New York, New York, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York, USA.
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Źródło:
Nature medicine [Nat Med] 2015 Oct; Vol. 21 (10), pp. 1190-8. Date of Electronic Publication: 2015 Sep 14.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA-Binding Proteins/*genetics
Germinal Center/*cytology
Lymphoma, Large B-Cell, Diffuse/*genetics
Neoplasm Proteins/*genetics
Animals ; B-Lymphocytes/pathology ; Cell Proliferation ; DNA Methylation ; Epigenesis, Genetic ; Gene Silencing ; Humans ; Lymphoma, Large B-Cell, Diffuse/etiology ; Mice ; Mutation, Missense ; Transcription, Genetic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Early life dynamics of the human gut virome and bacterial microbiome in infants.
Autorzy:
Lim ES; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.; Department of Pathology &Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Zhou Y; Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.
Zhao G; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Bauer IK; Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.
Droit L; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.; Department of Pathology &Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Ndao IM; Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.
Warner BB; Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.
Tarr PI; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.; Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.
Wang D; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.; Department of Pathology &Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Holtz LR; Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.
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Źródło:
Nature medicine [Nat Med] 2015 Oct; Vol. 21 (10), pp. 1228-34. Date of Electronic Publication: 2015 Sep 14.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Twin Study
MeSH Terms:
Microbiota*
Intestines/*microbiology
Cohort Studies ; Humans ; Infant ; Intestines/virology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 4336

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