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Wyszukujesz frazę ""Nedergaard, M."" wg kryterium: Autor


Tytuł :
Glymphatic failure as a final common pathway to dementia.
Autorzy :
Nedergaard M; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark. nedergaard@sund.ku.dk .; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA.
Goldman SA; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark. nedergaard@sund.ku.dk .; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2020 Oct 02; Vol. 370 (6512), pp. 50-56.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms :
Sleep*
Alzheimer Disease/*etiology
Glymphatic System/*physiopathology
Sleep Wake Disorders/*complications
Aging ; Alzheimer Disease/physiopathology ; Animals ; Aquaporin 4/genetics ; Cardiovascular Diseases/etiology ; Humans ; Lymphatic System/physiopathology ; Mice ; Polymorphism, Genetic ; Prion Proteins/metabolism ; Protein Aggregates ; Sleep Wake Disorders/physiopathology
Czasopismo naukowe
Tytuł :
An ocular glymphatic clearance system removes β-amyloid from the rodent eye.
Autorzy :
Wang X; Center for Translational Neuromedicine, Faculty of Medical and Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.; Center for Translational Neuromedicine, University of Rochester Medical School, Elmwood Avenue 601, Rochester, NY 14642, USA.
Lou N; Center for Translational Neuromedicine, University of Rochester Medical School, Elmwood Avenue 601, Rochester, NY 14642, USA.
Eberhardt A; Center for Translational Neuromedicine, University of Rochester Medical School, Elmwood Avenue 601, Rochester, NY 14642, USA.
Yang Y; Center for Eye Disease and Development, Vision Science Graduate Program, and School of Optometry, University of California Berkeley, Berkeley, CA 94720, USA.
Kusk P; Center for Translational Neuromedicine, Faculty of Medical and Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.
Xu Q; Center for Translational Neuromedicine, University of Rochester Medical School, Elmwood Avenue 601, Rochester, NY 14642, USA.
Förstera B; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilians University of Munich (LMU), 81377 Munich, Germany.; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center München, 85764 Munich, Germany.
Peng S; Center for Translational Neuromedicine, University of Rochester Medical School, Elmwood Avenue 601, Rochester, NY 14642, USA.
Shi M; Center for Eye Disease and Development, Vision Science Graduate Program, and School of Optometry, University of California Berkeley, Berkeley, CA 94720, USA.
Ladrón-de-Guevara A; Center for Translational Neuromedicine, University of Rochester Medical School, Elmwood Avenue 601, Rochester, NY 14642, USA.
Delle C; Center for Translational Neuromedicine, Faculty of Medical and Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.
Sigurdsson B; Center for Translational Neuromedicine, Faculty of Medical and Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.
Xavier ALR; Center for Translational Neuromedicine, Faculty of Medical and Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.
Ertürk A; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilians University of Munich (LMU), 81377 Munich, Germany.; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center München, 85764 Munich, Germany.
Libby RT; Department of Ophthalmology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Chen L; Center for Eye Disease and Development, Vision Science Graduate Program, and School of Optometry, University of California Berkeley, Berkeley, CA 94720, USA. nedergaard@sund.ku.dk .
Thrane AS; Center for Translational Neuromedicine, Faculty of Medical and Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.; Department of Ophthalmology, Haukeland University Hospital, Jonas Lies Vei 65, 5021 Bergen, Norway.
Nedergaard M; Center for Translational Neuromedicine, Faculty of Medical and Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark. nedergaard@sund.ku.dk .; Center for Translational Neuromedicine, University of Rochester Medical School, Elmwood Avenue 601, Rochester, NY 14642, USA.
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Źródło :
Science translational medicine [Sci Transl Med] 2020 Mar 25; Vol. 12 (536).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Czasopismo naukowe
Tytuł :
Cerebrospinal fluid influx drives acute ischemic tissue swelling.
Autorzy :
Mestre H; Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.; Department of Neuroscience, University of Rochester Medical Center, Rochester, NY 14642, USA.
Du T; Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.; School of Pharmacy, China Medical University, Shenyang 110122, China.
Sweeney AM; Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.
Liu G; Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.; Department of Neurosurgery, the Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China.
Samson AJ; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Peng W; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Mortensen KN; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Stæger FF; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Bork PAR; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.; Department of Applied Mathematics and Computer Science, Technical University of Denmark, Richard Petersens Plads, 2800 Kgs. Lyngby, Denmark.
Bashford L; Department of Mechanical Engineering, University of Rochester, Rochester, NY 14627, USA.
Toro ER; Department of Mechanical Engineering, University of Rochester, Rochester, NY 14627, USA.
Tithof J; Department of Mechanical Engineering, University of Rochester, Rochester, NY 14627, USA.
Kelley DH; Department of Mechanical Engineering, University of Rochester, Rochester, NY 14627, USA.
Thomas JH; Department of Mechanical Engineering, University of Rochester, Rochester, NY 14627, USA.
Hjorth PG; Department of Applied Mathematics and Computer Science, Technical University of Denmark, Richard Petersens Plads, 2800 Kgs. Lyngby, Denmark.
Martens EA; Department of Applied Mathematics and Computer Science, Technical University of Denmark, Richard Petersens Plads, 2800 Kgs. Lyngby, Denmark.
Mehta RI; Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.; Department of Neuroscience, University of Rochester Medical Center, Rochester, NY 14642, USA.; Department of Pathology, Rush University, Chicago, IL 60612, USA.; Rush Alzheimer's Disease Center, Rush University, Chicago, IL 60612, USA.
Solis O; Department of Neuroscience, University of Rochester Medical Center, Rochester, NY 14642, USA.
Blinder P; Neurobiology, Biochemistry and Biophysics School, George S. Wise Faculty of Life Sciences, Tel Aviv University, 30 Haim Levanon St., Tel Aviv 69978, Israel.; Sagol School for Neuroscience, Tel Aviv University, 30 Haim Levanon St., Tel Aviv 69978, Israel.
Kleinfeld D; Department of Physics, University of California, San Diego, La Jolla, CA 92093, USA.; Section of Neurobiology, University of California, San Diego, La Jolla, CA 92093, USA.
Hirase H; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.; Laboratory for Neuron-Glia Circuitry, RIKEN Center for Brain Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
Mori Y; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark. .
Nedergaard M; Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA. .; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
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Źródło :
Science (New York, N.Y.) [Science] 2020 Mar 13; Vol. 367 (6483). Date of Electronic Publication: 2020 Jan 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Brain Edema/*cerebrospinal fluid
Brain Edema/*etiology
Glymphatic System/*physiopathology
Stroke/*cerebrospinal fluid
Stroke/*complications
Animals ; Aquaporin 5/metabolism ; Brain Edema/diagnostic imaging ; Magnetic Resonance Imaging ; Male ; Mice ; Mice, Inbred C57BL ; Stroke/diagnostic imaging ; Vasoconstriction
Czasopismo naukowe
Tytuł :
Oxygen tension-mediated erythrocyte membrane interactions regulate cerebral capillary hyperemia.
Autorzy :
Zhou S; Microsystems Engineering, Rochester Institute of Technology, Rochester, NY 14623, USA.; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA.
Giannetto M; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA.
DeCourcey J; College of Osteopathic Medicine, University of New England, Biddeford, ME 04005, USA.
Kang H; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA.
Kang N; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA.
Li Y; Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Zheng S; Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.
Zhao H; New York University Langone Medical Center, New York, NY 10010, USA.
Simmons WR; National Human Genome Research Institute, Bethesda, MD 20894, USA.
Wei HS; Rutgers New Jersey Medical School, Newark, NJ 07101, USA.
Bodine DM; National Human Genome Research Institute, Bethesda, MD 20894, USA.
Low PS; Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.
Nedergaard M; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA.
Wan J; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA.; Department of Chemical Engineering, University of California, Davis, Davis, CA 95616, USA.
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Źródło :
Science advances [Sci Adv] 2019 May 29; Vol. 5 (5), pp. eaaw4466. Date of Electronic Publication: 2019 May 29 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Brain/*blood supply
Erythrocyte Membrane/*physiology
Hyperemia/*blood
Oxygen/*blood
Animals ; Anion Exchange Protein 1, Erythrocyte/genetics ; Anion Exchange Protein 1, Erythrocyte/metabolism ; Blood Flow Velocity/physiology ; Cerebrovascular Circulation ; Hemoglobins/chemistry ; Hemoglobins/metabolism ; Humans ; Hyperemia/physiopathology ; Lab-On-A-Chip Devices ; Mice, Inbred C57BL ; Mice, Transgenic
Czasopismo naukowe
Tytuł :
Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia.
Autorzy :
Hablitz LM; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA.
Vinitsky HS; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA.
Sun Q; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA.
Stæger FF; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Sigurdsson B; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Mortensen KN; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Lilius TO; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.; Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Nedergaard M; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA.; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
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Źródło :
Science advances [Sci Adv] 2019 Feb 27; Vol. 5 (2), pp. eaav5447. Date of Electronic Publication: 2019 Feb 27 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Delta Rhythm*
Electroencephalography*
Heart Rate*
Glymphatic System/*physiology
Anesthesia ; Animals ; Brain/blood supply ; Brain/physiology ; Female ; Male ; Mice
Czasopismo naukowe
Tytuł :
Fluorescent Ca indicators directly inhibit the Na,K-ATPase and disrupt cellular functions.
Autorzy :
Smith NA; Center for Translational Neuromedicine, Departments of Neurosurgery and Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA.; Center for Neuroscience Research, Children's Research Institute, Children's National Health System, Washington, DC 20010, USA.
Kress BT; Center for Translational Neuromedicine, Departments of Neurosurgery and Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Lu Y; Center for Translational Neuromedicine, Departments of Neurosurgery and Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Chandler-Militello D; Center for Translational Neuromedicine, Departments of Neurosurgery and Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Benraiss A; Center for Translational Neuromedicine, Departments of Neurosurgery and Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Nedergaard M; Center for Translational Neuromedicine, Departments of Neurosurgery and Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA. nedergaard@urmc.rochester.edu.
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Źródło :
Science signaling [Sci Signal] 2018 Jan 30; Vol. 11 (515). Date of Electronic Publication: 2018 Jan 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Astrocytes/*metabolism
Enzyme Inhibitors/*pharmacology
Fluorescent Dyes/*pharmacology
Kidney Tubules, Proximal/*metabolism
Myocytes, Cardiac/*metabolism
Neurons/*metabolism
Sodium-Potassium-Exchanging ATPase/*antagonists & inhibitors
Adenosine Triphosphate/metabolism ; Aniline Compounds/pharmacology ; Animals ; Astrocytes/drug effects ; Astrocytes/enzymology ; Cells, Cultured ; Fura-2/pharmacology ; Heterocyclic Compounds, 3-Ring/pharmacology ; Humans ; Kidney Tubules, Proximal/drug effects ; Kidney Tubules, Proximal/enzymology ; Mice ; Mice, Inbred C57BL ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/enzymology ; Neurons/drug effects ; Neurons/enzymology ; Potassium/metabolism ; Xanthenes/pharmacology
Czasopismo naukowe
Tytuł :
Changes in the composition of brain interstitial ions control the sleep-wake cycle.
Autorzy :
Ding F; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA. Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
O'Donnell J; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA.
Xu Q; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA.
Kang N; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA.
Goldman N; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA.
Nedergaard M; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA. Center for Basic and Translational Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark. nedergaard@urmc.rochester.edu.
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Źródło :
Science (New York, N.Y.) [Science] 2016 Apr 29; Vol. 352 (6285), pp. 550-5.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Cations/*metabolism
Cerebral Cortex/*physiology
Potassium/*metabolism
Sleep/*physiology
Wakefulness/*physiology
Animals ; Calcium/analysis ; Calcium/metabolism ; Cations/analysis ; Cerebral Cortex/chemistry ; Cerebral Cortex/drug effects ; Electroencephalography ; Magnesium/analysis ; Magnesium/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Neurons/drug effects ; Neurons/metabolism ; Neurons/physiology ; Neurotransmitter Agents/metabolism ; Neurotransmitter Agents/pharmacology ; Receptors, AMPA/metabolism ; Sleep/drug effects ; Sodium Channel Blockers/pharmacology ; Tetrodotoxin/pharmacology ; Wakefulness/drug effects
Czasopismo naukowe
Tytuł :
Sleep drives metabolite clearance from the adult brain.
Autorzy :
Xie L; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.
Kang H
Xu Q
Chen MJ
Liao Y
Thiyagarajan M
O'Donnell J
Christensen DJ
Nicholson C
Iliff JJ
Takano T
Deane R
Nedergaard M
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Źródło :
Science (New York, N.Y.) [Science] 2013 Oct 18; Vol. 342 (6156), pp. 373-7.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Amyloid beta-Peptides/*metabolism
Brain/*metabolism
Neurodegenerative Diseases/*metabolism
Sleep/*physiology
Adrenergic Antagonists/administration & dosage ; Animals ; Brain/physiology ; Cerebral Cortex/metabolism ; Cerebral Cortex/physiology ; Cerebrospinal Fluid/metabolism ; Diffusion ; Electroencephalography ; Extracellular Space ; Intracellular Space ; Male ; Mice ; Mice, Inbred C57BL ; Quaternary Ammonium Compounds/chemistry ; Receptors, Adrenergic/metabolism ; Wakefulness/physiology
Czasopismo naukowe
Tytuł :
Neuroscience. Garbage truck of the brain.
Autorzy :
Nedergaard M; School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY 14642, USA. nedergaard@urmc.rochester.edu
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Źródło :
Science (New York, N.Y.) [Science] 2013 Jun 28; Vol. 340 (6140), pp. 1529-30.
Typ publikacji :
Journal Article
MeSH Terms :
Aquaporin 4/*metabolism
Brain/*physiopathology
Lymphatic Vessels/*metabolism
Neurodegenerative Diseases/*physiopathology
Neurodegenerative Diseases/*therapy
Neuroglia/*metabolism
Animals ; Cerebrospinal Fluid/metabolism ; Extracellular Fluid/metabolism ; Humans ; Mice ; Neurodegenerative Diseases/cerebrospinal fluid ; Neurons/metabolism ; Rats
Czasopismo naukowe
Tytuł :
Glutamate-dependent neuroglial calcium signaling differs between young and adult brain.
Autorzy :
Sun W; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester, Rochester, NY 14642, USA.
McConnell E
Pare JF
Xu Q
Chen M
Peng W
Lovatt D
Han X
Smith Y
Nedergaard M
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Źródło :
Science (New York, N.Y.) [Science] 2013 Jan 11; Vol. 339 (6116), pp. 197-200.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Aging*
Calcium Signaling*
Astrocytes/*metabolism
Cerebral Cortex/*metabolism
Glutamic Acid/*metabolism
Receptors, Metabotropic Glutamate/*metabolism
Adolescent ; Animals ; Calcium/metabolism ; Cerebral Cortex/cytology ; Cerebral Cortex/ultrastructure ; Female ; Hippocampus/cytology ; Hippocampus/metabolism ; Hippocampus/ultrastructure ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Receptor, Metabotropic Glutamate 5 ; Receptors, Metabotropic Glutamate/agonists ; Synaptic Transmission
Czasopismo naukowe

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