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Tytuł :
Meningeal Lymphangiogenesis and Enhanced Glymphatic Activity in Mice with Chronically Implanted EEG Electrodes.
Autorzy :
Hauglund NL; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Kusk P; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Kornum BR; Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark, and.
Nedergaard M; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark, .; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York 14642.
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2020 Mar 11; Vol. 40 (11), pp. 2371-2380. Date of Electronic Publication: 2020 Feb 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Lymphangiogenesis*
Dura Mater/*metabolism
Electrodes, Implanted/*adverse effects
Foreign-Body Reaction/*etiology
Gliosis/*etiology
Glymphatic System/*physiology
Animals ; Astrocytes/physiology ; Cerebral Cortex/pathology ; Cerebrospinal Fluid/physiology ; Dura Mater/pathology ; Electroencephalography/instrumentation ; Female ; Foreign-Body Reaction/metabolism ; Gliosis/metabolism ; Gliosis/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Microglia/physiology ; Skin Window Technique ; Sleep Stages/physiology
Czasopismo naukowe
Tytuł :
Impaired Glymphatic Transport in Spontaneously Hypertensive Rats.
Autorzy :
Mortensen KN; Center for Translational Neuromedicine, University of Copenhagen, Copenhagen N, Denmark, 2200.
Sanggaard S; Center for Translational Neuromedicine, University of Copenhagen, Copenhagen N, Denmark, 2200.; Department of Anesthesiology, Yale School of Medicine, Yale University, New Haven, Connecticut 06520-8051.
Mestre H; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York 14642.
Lee H; Department of Anesthesiology, Yale School of Medicine, Yale University, New Haven, Connecticut 06520-8051.
Kostrikov S; Center for Translational Neuromedicine, University of Copenhagen, Copenhagen N, Denmark, 2200.
Xavier ALR; Center for Translational Neuromedicine, University of Copenhagen, Copenhagen N, Denmark, 2200.
Gjedde A; Departments of Clinical Research and Nuclear Medicine, Odense University Hospital, University of Southern Denmark, Odense C, Denmark 5000, and.; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.
Benveniste H; Department of Anesthesiology, Yale School of Medicine, Yale University, New Haven, Connecticut 06520-8051.
Nedergaard M; Center for Translational Neuromedicine, University of Copenhagen, Copenhagen N, Denmark, 2200, nedergaard@sund.ku.dk.; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York 14642.
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2019 Aug 07; Vol. 39 (32), pp. 6365-6377. Date of Electronic Publication: 2019 Jun 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Glymphatic System/*physiopathology
Hypertension/*physiopathology
Age Factors ; Alzheimer Disease/physiopathology ; Animals ; Cerebral Ventricles/pathology ; Cerebrospinal Fluid/physiology ; Contrast Media/pharmacokinetics ; Disease Progression ; Heterocyclic Compounds/cerebrospinal fluid ; Heterocyclic Compounds/pharmacokinetics ; Magnetic Resonance Imaging/methods ; Male ; Organ Size ; Organometallic Compounds/cerebrospinal fluid ; Organometallic Compounds/pharmacokinetics ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Rheology
Czasopismo naukowe
Tytuł :
SOX9 Is an Astrocyte-Specific Nuclear Marker in the Adult Brain Outside the Neurogenic Regions.
Autorzy :
Sun W; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York 14642, and nedergaard@urmc.rochester.edu.
Cornwell A; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York 14642, and.
Li J; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York 14642, and.
Peng S; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York 14642, and.
Osorio MJ; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York 14642, and.
Aalling N; Center for Basic and Translational Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen 2200 Copenhagen, Denmark.
Wang S; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York 14642, and.
Benraiss A; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York 14642, and.
Lou N; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York 14642, and.
Goldman SA; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York 14642, and.; Center for Basic and Translational Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen 2200 Copenhagen, Denmark.
Nedergaard M; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York 14642, and nedergaard@urmc.rochester.edu.; Center for Basic and Translational Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen 2200 Copenhagen, Denmark.
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2017 Apr 26; Vol. 37 (17), pp. 4493-4507. Date of Electronic Publication: 2017 Mar 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms :
Astrocytes/*metabolism
SOX9 Transcription Factor/*metabolism
Adult ; Aging ; Animals ; Biomarkers ; Brain Ischemia/genetics ; Brain Ischemia/metabolism ; Excitatory Amino Acid Transporter 2/metabolism ; Gene Expression Regulation/genetics ; Gene Expression Regulation/physiology ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Neural Stem Cells/metabolism ; Neurogenesis ; RNA/biosynthesis ; SOX9 Transcription Factor/genetics ; Stroke/genetics ; Stroke/metabolism ; Transcriptome/genetics
Czasopismo naukowe
Tytuł :
Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts.
Autorzy :
Wang M; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642.; Department of Neurology, Tongii Hospital, Tongii Medical College, Huazhong University of Science and Technology, Wuhan, China 430030.
Ding F; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642.; Department of Neurology, Tongii Hospital, Tongii Medical College, Huazhong University of Science and Technology, Wuhan, China 430030.
Deng S; Department of Neurology, Tongii Hospital, Tongii Medical College, Huazhong University of Science and Technology, Wuhan, China 430030.
Guo X; Department of Neurology, Tongii Hospital, Tongii Medical College, Huazhong University of Science and Technology, Wuhan, China 430030.
Wang W; Department of Neurology, Tongii Hospital, Tongii Medical College, Huazhong University of Science and Technology, Wuhan, China 430030.
Iliff JJ; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642, Nedergaard@URMC.Rochester.edu.; Department of Anesthesiology and Perioperative Medicine, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon 97239, and.
Nedergaard M; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642, Nedergaard@URMC.Rochester.edu.; Center for Basic and Translational Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark.
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2017 Mar 15; Vol. 37 (11), pp. 2870-2877. Date of Electronic Publication: 2017 Feb 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms :
Disease Models, Animal*
Signal Transduction*
Cerebral Arteries/*metabolism
Cerebrospinal Fluid/*metabolism
Extracellular Fluid/*metabolism
Myocardial Infarction/*cerebrospinal fluid
Animals ; Cerebral Arteries/pathology ; Cerebrospinal Fluid/cytology ; Extracellular Fluid/cytology ; Male ; Mice ; Mice, Inbred C57BL ; Myocardial Infarction/pathology
Czasopismo naukowe
Tytuł :
A Distinct Population of Microglia Supports Adult Neurogenesis in the Subventricular Zone.
Autorzy :
Ribeiro Xavier AL; Laboratório de Neuroanatomia Celular, Instituto de Ciências Biomédicas, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941-902 Brazil, Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, New York 14642, and.
Kress BT; Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, New York 14642, and.
Goldman SA; Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, New York 14642, and Center for Basic and Translational Neuroscience, University of Copenhagen, 2200N Copenhagen, Denmark.
Lacerda de Menezes JR; Laboratório de Neuroanatomia Celular, Instituto de Ciências Biomédicas, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941-902 Brazil.
Nedergaard M; Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, New York 14642, and Center for Basic and Translational Neuroscience, University of Copenhagen, 2200N Copenhagen, Denmark nedergaard@urmc.rochester.edu.
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2015 Aug 26; Vol. 35 (34), pp. 11848-61.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Lateral Ventricles/*cytology
Lateral Ventricles/*physiology
Microglia/*physiology
Neurogenesis/*physiology
Animals ; Animals, Newborn ; Female ; Male ; Mice ; Mice, 129 Strain ; Mice, Inbred C57BL ; Mice, Transgenic ; Neural Stem Cells/physiology
Czasopismo naukowe
Tytuł :
The Effect of Body Posture on Brain Glymphatic Transport.
Autorzy :
Lee H; Department of Anesthesiology, Department of Radiology, and.
Xie L; Center for Translational Neuromedicine, University of Rochester, Rochester, New York 14627.
Yu M; Department of Anesthesiology.
Kang H; Center for Translational Neuromedicine, University of Rochester, Rochester, New York 14627.
Feng T; Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, New York 11794.
Deane R; Center for Translational Neuromedicine, University of Rochester, Rochester, New York 14627.
Logan J; Department of Radiology, New York University Langone Medical Center, New York, New York 10016, and.
Nedergaard M; Center for Translational Neuromedicine, University of Rochester, Rochester, New York 14627.
Benveniste H; Department of Anesthesiology, Department of Radiology, and .
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2015 Aug 05; Vol. 35 (31), pp. 11034-44.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Amyloid beta-Peptides/*metabolism
Brain/*metabolism
Cerebrospinal Fluid/*metabolism
Posture/*physiology
Animals ; Biological Transport ; Female ; Magnetic Resonance Imaging ; Mice ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Biomarkers of traumatic injury are transported from brain to blood via the glymphatic system.
Autorzy :
Plog BA; Center for Translational Neuromedicine, Department of Neurosurgery and Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642.
Dashnaw ML; Center for Translational Neuromedicine, Department of Neurosurgery and.
Hitomi E; Center for Translational Neuromedicine, Department of Neurosurgery and.
Peng W; Center for Translational Neuromedicine, Department of Neurosurgery and.
Liao Y; Center for Translational Neuromedicine, Department of Neurosurgery and.
Lou N; Center for Translational Neuromedicine, Department of Neurosurgery and.
Deane R; Center for Translational Neuromedicine, Department of Neurosurgery and.
Nedergaard M; Center for Translational Neuromedicine, Department of Neurosurgery and .
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2015 Jan 14; Vol. 35 (2), pp. 518-26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Metabolic Clearance Rate*
Brain Injuries/*metabolism
Extracellular Fluid/*metabolism
Animals ; Biomarkers/blood ; Biomarkers/cerebrospinal fluid ; Blood-Brain Barrier/metabolism ; Brain Injuries/blood ; Brain Injuries/cerebrospinal fluid ; Female ; Glial Fibrillary Acidic Protein/blood ; Glial Fibrillary Acidic Protein/cerebrospinal fluid ; Mice ; Mice, Inbred C57BL ; Neuroglia/metabolism ; S100 Calcium Binding Protein beta Subunit/blood ; S100 Calcium Binding Protein beta Subunit/cerebrospinal fluid ; Sleep Deprivation/blood ; Sleep Deprivation/cerebrospinal fluid ; Sleep Deprivation/metabolism
Czasopismo naukowe
Tytuł :
Neuronal transgene expression in dominant-negative SNARE mice.
Autorzy :
Fujita T; Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, New York 14642 nedergaard@urmc.rochester.edu .
Chen MJ; Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, New York 14642.
Li B; Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, New York 14642.
Smith NA; Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, New York 14642.
Peng W; Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, New York 14642.
Sun W; Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, New York 14642.
Toner MJ; Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, New York 14642.
Kress BT; Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, New York 14642.
Wang L; Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, New York 14642.
Benraiss A; Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, New York 14642.
Takano T; Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, New York 14642.
Wang S; Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, New York 14642.
Nedergaard M; Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, New York 14642 nedergaard@urmc.rochester.edu .
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2014 Dec 10; Vol. 34 (50), pp. 16594-604.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Gene Expression Regulation*
Neurons/*metabolism
SNARE Proteins/*biosynthesis
Animals ; Animals, Newborn ; Cells, Cultured ; Electroencephalography/methods ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; SNARE Proteins/genetics ; Sleep Stages/physiology
Czasopismo naukowe
Tytuł :
Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury.
Autorzy :
Iliff JJ; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642 and Department of Anesthesiology and Peri-Operative Medicine, and Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon 97239 .
Chen MJ; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642 and.
Plog BA; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642 and.
Zeppenfeld DM; Department of Anesthesiology and Peri-Operative Medicine, and Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon 97239.
Soltero M; Department of Anesthesiology and Peri-Operative Medicine, and.
Yang L; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642 and.
Singh I; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642 and.
Deane R; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642 and.
Nedergaard M; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642 and.
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2014 Dec 03; Vol. 34 (49), pp. 16180-93.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain Injuries/*metabolism
Brain Injuries/*pathology
Cerebrospinal Fluid/*metabolism
Extracellular Fluid/*metabolism
Neurofibrillary Tangles/*metabolism
Neurofibrillary Tangles/*pathology
tau Proteins/*metabolism
Animals ; Aquaporin 4/genetics ; Brain Injuries/complications ; Brain Injuries/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Nerve Degeneration/genetics ; Nerve Degeneration/metabolism ; Nerve Degeneration/pathology ; Neurofibrillary Tangles/genetics
Czasopismo naukowe
Tytuł :
Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain.
Autorzy :
Iliff JJ; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642, Department of Anesthesiology and Peri-Operative Medicine, Oregon Health & Science University, Portland, Oregon 97239, and Department of Neurology, Tongii Hospital, Tongii Medical College, Huazhong University of Science and Technology, Wuhan, China 430030.
Wang M
Zeppenfeld DM
Venkataraman A
Plog BA
Liao Y
Deane R
Nedergaard M
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2013 Nov 13; Vol. 33 (46), pp. 18190-9.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Blood Flow Velocity/*physiology
Brain/*blood supply
Brain/*physiology
Cerebral Arteries/*physiology
Cerebrospinal Fluid/*physiology
Animals ; Brain Chemistry/physiology ; Cerebral Arteries/chemistry ; Cerebrospinal Fluid/chemistry ; Extracellular Fluid/chemistry ; Extracellular Fluid/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Microscopy, Fluorescence, Multiphoton/methods
Czasopismo naukowe
Tytuł :
Photolysis of caged Ca2+ but not receptor-mediated Ca2+ signaling triggers astrocytic glutamate release.
Autorzy :
Wang F; Center for Translational Neuromedicine, Division of Glia Disease and Therapeutics, University of Rochester Medical School, Rochester, New York 14642.
Smith NA
Xu Q
Goldman S
Peng W
Huang JH
Takano T
Nedergaard M
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2013 Oct 30; Vol. 33 (44), pp. 17404-12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Photolysis*
Astrocytes/*metabolism
Calcium Signaling/*genetics
Glutamic Acid/*metabolism
Animals ; Down-Regulation/genetics ; Excitatory Postsynaptic Potentials/genetics ; Female ; Hippocampus/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Neural Inhibition/genetics ; Organ Culture Techniques ; Receptors, G-Protein-Coupled/agonists ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; SNARE Proteins/deficiency ; SNARE Proteins/genetics
Czasopismo naukowe
Tytuł :
Cognitive deficits and delayed neuronal loss in a mouse model of multiple microinfarcts.
Autorzy :
Wang M; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642, USA.
Iliff JJ
Liao Y
Chen MJ
Shinseki MS
Venkataraman A
Cheung J
Wang W
Nedergaard M
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2012 Dec 12; Vol. 32 (50), pp. 17948-60.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Brain/*pathology
Cerebral Infarction/*complications
Cerebral Infarction/*pathology
Cognition Disorders/*etiology
Cognition Disorders/*pathology
Nerve Degeneration/*etiology
Nerve Degeneration/*pathology
Neurons/*pathology
Animals ; Disease Models, Animal ; Immunohistochemistry ; Male ; Mice ; Mice, Inbred C57BL ; Microscopy, Confocal ; Neuroglia/pathology
Czasopismo naukowe
Tytuł :
Alexander disease.
Autorzy :
Messing A; Waisman Center and Department of Comparative Biosciences, University of Wisconsin Madison, Madison, Wisconsin 53705, USA. />Brenner M
Feany MB
Nedergaard M
Goldman JE
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2012 Apr 11; Vol. 32 (15), pp. 5017-23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Alexander Disease/*pathology
Age of Onset ; Alexander Disease/genetics ; Alexander Disease/therapy ; Animals ; Astrocytes/pathology ; Brain/pathology ; Disease Models, Animal ; Glial Fibrillary Acidic Protein/physiology ; Glial Fibrillary Acidic Protein/toxicity ; Humans ; Models, Neurological ; Neural Pathways/pathology
Czasopismo naukowe
Tytuł :
Critical role of connexin 43 in secondary expansion of traumatic spinal cord injury.
Autorzy :
Huang C; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester, Rochester, New York 14642, USA.
Han X
Li X
Lam E
Peng W
Lou N
Torres A
Yang M
Garre JM
Tian GF
Bennett MV
Nedergaard M
Takano T
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2012 Mar 07; Vol. 32 (10), pp. 3333-8.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Connexin 43/*physiology
Spinal Cord Injuries/*metabolism
Adenosine Triphosphate/metabolism ; Animals ; Connexin 43/biosynthesis ; Connexin 43/genetics ; Female ; Gene Expression Regulation/physiology ; Mice ; Mice, Knockout ; Mice, Transgenic ; Spinal Cord Injuries/genetics ; Spinal Cord Injuries/pathology
Czasopismo naukowe
Tytuł :
Uniquely hominid features of adult human astrocytes.
Autorzy :
Oberheim NA; Center for Translational Neuromedicine, Department of Neurology, University of Rochester Medical Center, Rochester, New York 14642, USA.
Takano T
Han X
He W
Lin JH
Wang F
Xu Q
Wyatt JD
Pilcher W
Ojemann JG
Ransom BR
Goldman SA
Nedergaard M
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2009 Mar 11; Vol. 29 (10), pp. 3276-87.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Astrocytes/*cytology
Astrocytes/*physiology
Adolescent ; Adult ; Aged ; Animals ; Astrocytes/ultrastructure ; Child ; Child, Preschool ; Hominidae ; Humans ; Macaca mulatta ; Mice ; Middle Aged ; Pan troglodytes ; Rats ; Rats, Sprague-Dawley ; Saimiri ; Species Specificity ; Young Adult
Czasopismo naukowe
Tytuł :
Connexin 43 hemichannels are permeable to ATP.
Autorzy :
Kang J; Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA. />Kang N
Lovatt D
Torres A
Zhao Z
Lin J
Nedergaard M
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2008 Apr 30; Vol. 28 (18), pp. 4702-11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Adenosine Triphosphate/*metabolism
Connexin 43/*metabolism
Ion Channel Gating/*physiology
Adenosine Triphosphate/pharmacology ; Analysis of Variance ; Animals ; Animals, Newborn ; Carbenoxolone/pharmacology ; Cell Line, Transformed ; Connexin 43/genetics ; Dose-Response Relationship, Radiation ; Electric Stimulation/methods ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; In Vitro Techniques ; Ion Channel Gating/drug effects ; Mutation ; Nitrobenzoates/pharmacology ; Patch-Clamp Techniques ; Potassium Channel Blockers/pharmacology ; Rats ; Rats, Sprague-Dawley ; Tetraethylammonium/pharmacology ; Transfection/methods
Czasopismo naukowe
Tytuł :
Loss of astrocytic domain organization in the epileptic brain.
Autorzy :
Oberheim NA; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642, USA.
Tian GF
Han X
Peng W
Takano T
Ransom B
Nedergaard M
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2008 Mar 26; Vol. 28 (13), pp. 3264-76.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Astrocytes/*physiology
Brain/*pathology
Epilepsy/*pathology
Amino Acids ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Animals ; Anticonvulsants/therapeutic use ; Astrocytes/drug effects ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Behavior, Animal ; Brain/drug effects ; Brain/physiopathology ; Dendrites/pathology ; Disease Models, Animal ; Electroencephalography/methods ; Epilepsy/chemically induced ; Epilepsy/drug therapy ; Epilepsy/genetics ; Gene Expression Regulation/physiology ; Glial Fibrillary Acidic Protein/genetics ; Glial Fibrillary Acidic Protein/metabolism ; Kainic Acid ; Luminescent Proteins/genetics ; Luminescent Proteins/metabolism ; Mice ; Mice, Transgenic ; Nerve Tissue Proteins/metabolism ; Neurons/metabolism ; Time Factors ; Valproic Acid/therapeutic use
Czasopismo naukowe

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