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Wyszukujesz frazę ""Nedergaard, M."" wg kryterium: Autor


Tytuł :
Does Global Astrocytic Calcium Signaling Participate in Awake Brain State Transitions and Neuronal Circuit Function?
Autorzy :
Kjaerby C; Center for Basic and Translational Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Building 24.2, Blegdamsvej 3B, 2200, Copenhagen N, Denmark.
Rasmussen R; Center for Basic and Translational Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Building 24.2, Blegdamsvej 3B, 2200, Copenhagen N, Denmark.; Department of Biomedicine, The Danish Research Institute of Translational Neuroscience - DANDRITE, Nordic EMBL Partnership for Molecular Medicine, Aarhus University, 8000, Aarhus C, Denmark.
Andersen M; Center for Basic and Translational Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Building 24.2, Blegdamsvej 3B, 2200, Copenhagen N, Denmark.
Nedergaard M; Center for Basic and Translational Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Building 24.2, Blegdamsvej 3B, 2200, Copenhagen N, Denmark. nedergaard@sund.ku.dk.; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, 14642, USA. nedergaard@sund.ku.dk.
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Źródło :
Neurochemical research [Neurochem Res] 2017 Jun; Vol. 42 (6), pp. 1810-1822. Date of Electronic Publication: 2017 Feb 16.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Astrocytes/*metabolism
Brain/*metabolism
Calcium Signaling/*physiology
Nerve Net/*metabolism
Neurons/*metabolism
Wakefulness/*physiology
Animals ; Humans ; Neurotransmitter Agents/metabolism
Czasopismo naukowe
Tytuł :
How do astrocytes participate in neural plasticity?
Autorzy :
Haydon PG; Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111.
Nedergaard M; Center for Translational Neuromedicine, Division of Glial Disease and Therapeutics, University of Rochester Medical Center, Rochester, New York 14642.
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Źródło :
Cold Spring Harbor perspectives in biology [Cold Spring Harb Perspect Biol] 2014 Dec 11; Vol. 7 (3), pp. a020438. Date of Electronic Publication: 2014 Dec 11.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Models, Neurological*
Action Potentials/*physiology
Astrocytes/*physiology
Calcium Signaling/*physiology
Neuronal Plasticity/*physiology
Animals ; Humans ; Mice ; Neurotransmitter Agents/metabolism ; Potassium/metabolism
Czasopismo naukowe
Tytuł :
α1-Adrenergic receptors mediate coordinated Ca2+ signaling of cortical astrocytes in awake, behaving mice.
Autorzy :
Ding F; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642.
O'Donnell J; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642.
Thrane AS; Department of Ophthalmology, Haukeland University Hospital, Bergen 5021, Norway.
Zeppenfeld D; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642.
Kang H; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642.
Xie L; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642.
Wang F; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642.
Nedergaard M; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642.
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Źródło :
Cell calcium [Cell Calcium] 2013 Dec; Vol. 54 (6), pp. 387-94. Date of Electronic Publication: 2013 Sep 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium Signaling*
Astrocytes/*metabolism
Receptors, Adrenergic, alpha-1/*metabolism
Adrenergic alpha-1 Receptor Agonists/pharmacology ; Adrenergic alpha-1 Receptor Antagonists/pharmacology ; Animals ; Behavior, Animal/drug effects ; Benzylamines/pharmacology ; Cerebral Cortex/drug effects ; Cerebral Cortex/metabolism ; Locus Coeruleus/drug effects ; Locus Coeruleus/metabolism ; Mice ; Mice, Inbred C57BL ; Neurotransmitter Uptake Inhibitors/pharmacology ; Norepinephrine/metabolism ; Prazosin/pharmacology ; Receptors, Adrenergic, alpha-1/chemistry
Czasopismo naukowe
Tytuł :
Photolysis of caged Ca2+ but not receptor-mediated Ca2+ signaling triggers astrocytic glutamate release.
Autorzy :
Wang F; Center for Translational Neuromedicine, Division of Glia Disease and Therapeutics, University of Rochester Medical School, Rochester, New York 14642.
Smith NA
Xu Q
Goldman S
Peng W
Huang JH
Takano T
Nedergaard M
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2013 Oct 30; Vol. 33 (44), pp. 17404-12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Photolysis*
Astrocytes/*metabolism
Calcium Signaling/*genetics
Glutamic Acid/*metabolism
Animals ; Down-Regulation/genetics ; Excitatory Postsynaptic Potentials/genetics ; Female ; Hippocampus/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Neural Inhibition/genetics ; Organ Culture Techniques ; Receptors, G-Protein-Coupled/agonists ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; SNARE Proteins/deficiency ; SNARE Proteins/genetics
Czasopismo naukowe
Tytuł :
A link between glial Ca2+ signaling and hypoxia in aging?
Autorzy :
Iliff JJ; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester, Rochester, New York 14642, USA.
Nedergaard M
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Źródło :
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2013 Feb; Vol. 33 (2), pp. 170. Date of Electronic Publication: 2012 Dec 05.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Calcium Signaling*
Aging/*immunology
Calcium/*metabolism
Hypoxia, Brain/*metabolism
Neuroglia/*metabolism
Oxygen/*metabolism
Purkinje Cells/*metabolism
Animals
Czasopismo naukowe
Tytuł :
Glutamate-dependent neuroglial calcium signaling differs between young and adult brain.
Autorzy :
Sun W; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester, Rochester, NY 14642, USA.
McConnell E
Pare JF
Xu Q
Chen M
Peng W
Lovatt D
Han X
Smith Y
Nedergaard M
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Źródło :
Science (New York, N.Y.) [Science] 2013 Jan 11; Vol. 339 (6116), pp. 197-200.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Aging*
Calcium Signaling*
Astrocytes/*metabolism
Cerebral Cortex/*metabolism
Glutamic Acid/*metabolism
Receptors, Metabotropic Glutamate/*metabolism
Adolescent ; Animals ; Calcium/metabolism ; Cerebral Cortex/cytology ; Cerebral Cortex/ultrastructure ; Female ; Hippocampus/cytology ; Hippocampus/metabolism ; Hippocampus/ultrastructure ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Receptor, Metabotropic Glutamate 5 ; Receptors, Metabotropic Glutamate/agonists ; Synaptic Transmission
Czasopismo naukowe
Tytuł :
General anesthesia selectively disrupts astrocyte calcium signaling in the awake mouse cortex.
Autorzy :
Thrane AS; Division of Glial Disease and Therapeutics, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA. />Rangroo Thrane V
Zeppenfeld D
Lou N
Xu Q
Nagelhus EA
Nedergaard M
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2012 Nov 13; Vol. 109 (46), pp. 18974-9. Date of Electronic Publication: 2012 Oct 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Anesthesia, General*
Anesthetics/*pharmacology
Astrocytes/*metabolism
Calcium Signaling/*drug effects
Synapses/*metabolism
Wakefulness/*drug effects
Animals ; Inositol 1,4,5-Trisphosphate Receptors/metabolism ; Mice ; Mice, Knockout
Czasopismo naukowe
Tytuł :
Bergmann glia modulate cerebellar Purkinje cell bistability via Ca2+-dependent K+ uptake.
Autorzy :
Wang F; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester, Rochester, NY 14642, USA. />Xu Q
Wang W
Takano T
Nedergaard M
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2012 May 15; Vol. 109 (20), pp. 7911-6. Date of Electronic Publication: 2012 Apr 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium Signaling/*physiology
Cerebellum/*cytology
Membrane Potentials/*physiology
Neuroglia/*physiology
Potassium/*metabolism
Purkinje Cells/*metabolism
Action Potentials/physiology ; Animals ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Microelectrodes ; Microscopy, Confocal ; Purkinje Cells/cytology ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Extracellular Ca²⁺ acts as a mediator of communication from neurons to glia.
Autorzy :
Torres A; Center for Translational Neuromedicine, Division of Glial Disease and Therapeutics, University of Rochester Medical School, 601 Elmwood Avenue, Rochester, NY 14642, USA.
Wang F
Xu Q
Fujita T
Dobrowolski R
Willecke K
Takano T
Nedergaard M
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Źródło :
Science signaling [Sci Signal] 2012 Jan 24; Vol. 5 (208), pp. ra8. Date of Electronic Publication: 2012 Jan 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Astrocytes/*metabolism
Calcium/*metabolism
Calcium Signaling/*physiology
Cell Communication/*physiology
Neurons/*metabolism
Synaptic Transmission/*physiology
Action Potentials/physiology ; Adenosine Triphosphate/genetics ; Adenosine Triphosphate/metabolism ; Animals ; Astrocytes/cytology ; Glutamic Acid/genetics ; Glutamic Acid/metabolism ; Mice ; Mice, Knockout ; Neurons/cytology ; Receptors, Purinergic P2Y1/genetics ; Receptors, Purinergic P2Y1/metabolism
Czasopismo naukowe
Tytuł :
Adrenoceptors in brain: cellular gene expression and effects on astrocytic metabolism and [Ca(2+)]i.
Autorzy :
Hertz L; Department of Clinical Pharmacology, College of Basic Medical Sciences, China Medical University, Shenyang, PR China. />Lovatt D
Goldman SA
Nedergaard M
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Źródło :
Neurochemistry international [Neurochem Int] 2010 Nov; Vol. 57 (4), pp. 411-20. Date of Electronic Publication: 2010 Apr 07.
Typ publikacji :
Journal Article
MeSH Terms :
Astrocytes/*metabolism
Brain Chemistry/*genetics
Brain Chemistry/*physiology
Calcium Signaling/*physiology
Receptors, Adrenergic/*biosynthesis
Receptors, Adrenergic/*genetics
Animals ; Cell Separation ; Cells, Cultured ; Flow Cytometry ; Gene Expression/physiology ; Glucose/metabolism ; Glycogen/metabolism ; Mice ; Mice, Transgenic/physiology ; Microarray Analysis ; Mitochondria/metabolism ; Oxidation-Reduction ; Pyruvic Acid/metabolism ; RNA/biosynthesis ; RNA/genetics ; Receptors, Adrenergic, alpha-1/biosynthesis ; Receptors, Adrenergic, alpha-1/genetics ; Receptors, Adrenergic, alpha-2/biosynthesis ; Receptors, Adrenergic, alpha-2/genetics ; Receptors, Adrenergic, beta/biosynthesis ; Receptors, Adrenergic, beta/genetics
Czasopismo naukowe
Tytuł :
Calcium dyshomeostasis and pathological calcium signalling in neurological diseases.
Autorzy :
Nedergaard M
Verkhratsky A
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Źródło :
Cell calcium [Cell Calcium] 2010 Feb; Vol. 47 (2), pp. 101-2. Date of Electronic Publication: 2010 Jan 15.
Typ publikacji :
Editorial
MeSH Terms :
Calcium Signaling*
Calcium/*metabolism
Nervous System Diseases/*metabolism
Neurons/*metabolism
Animals ; Cell Death ; Homeostasis ; Humans ; Nervous System Diseases/pathology ; Neurons/pathology
Opinia redakcyjna
Tytuł :
Glial calcium and diseases of the nervous system.
Autorzy :
Nedergaard M; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA. nedergaard@urmc.rochester.edu
Rodríguez JJ
Verkhratsky A
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Źródło :
Cell calcium [Cell Calcium] 2010 Feb; Vol. 47 (2), pp. 140-9. Date of Electronic Publication: 2009 Dec 31.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Calcium Signaling*
Calcium/*metabolism
Neuroglia/*metabolism
Peripheral Nervous System Diseases/*metabolism
Animals ; Humans ; Neuroglia/pathology ; Neurons/metabolism ; Neurons/pathology ; Peripheral Nervous System Diseases/pathology ; Synaptic Transmission
Czasopismo naukowe
Tytuł :
Astrocytic calcium signaling: mechanism and implications for functional brain imaging.
Autorzy :
Wang X; Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY, USA.
Takano T
Nedergaard M
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2009; Vol. 489, pp. 93-109.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Calcium Signaling*
Astrocytes/*metabolism
Brain/*anatomy & histology
Animals ; Humans ; Magnetic Resonance Imaging
Czasopismo naukowe
Tytuł :
Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's disease.
Autorzy :
Takano T; Department of Neurosurgery, Center for Aging and Developmental Biology, University of Rochester Medical Center, 601 Elmwood Ave, Box 645, Rochester, NY 14642, USA. />Han X
Deane R
Zlokovic B
Nedergaard M
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Źródło :
Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2007 Feb; Vol. 1097, pp. 40-50.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Alzheimer Disease/*pathology
Astrocytes/*physiology
Blood Vessels/*pathology
Calcium Signaling/*physiology
Absorptiometry, Photon ; Alzheimer Disease/physiopathology ; Animals ; Blood Vessels/physiopathology ; Brain/physiology ; Capillaries/pathology ; Disease Models, Animal ; Humans ; Mice ; Microcirculation/physiology
Czasopismo naukowe
Tytuł :
Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo.
Autorzy :
Wang X; Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA.
Lou N
Xu Q
Tian GF
Peng WG
Han X
Kang J
Takano T
Nedergaard M
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Źródło :
Nature neuroscience [Nat Neurosci] 2006 Jun; Vol. 9 (6), pp. 816-23. Date of Electronic Publication: 2006 May 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Afferent Pathways/*physiology
Astrocytes/*metabolism
Calcium Signaling/*physiology
Mechanoreceptors/*physiology
Somatosensory Cortex/*physiology
Touch/*physiology
Animals ; Astrocytes/drug effects ; Calcium/metabolism ; Calcium Signaling/drug effects ; Cell Communication/drug effects ; Cell Communication/physiology ; Excitatory Amino Acid Antagonists/pharmacology ; Excitatory Postsynaptic Potentials/drug effects ; Excitatory Postsynaptic Potentials/physiology ; Female ; Male ; Mice ; Physical Stimulation ; Reaction Time/drug effects ; Reaction Time/physiology ; Receptors, AMPA/antagonists & inhibitors ; Receptors, AMPA/metabolism ; Receptors, Metabotropic Glutamate/agonists ; Receptors, Metabotropic Glutamate/metabolism ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors ; Receptors, N-Methyl-D-Aspartate/metabolism ; Somatosensory Cortex/cytology ; Synaptic Transmission/drug effects ; Synaptic Transmission/physiology ; Up-Regulation/drug effects ; Up-Regulation/physiology ; Vibrissae/innervation ; Vibrissae/physiology
Czasopismo naukowe
Tytuł :
An astrocytic basis of epilepsy.
Autorzy :
Tian GF; Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA.
Azmi H
Takano T
Xu Q
Peng W
Lin J
Oberheim N
Lou N
Wang X
Zielke HR
Kang J
Nedergaard M
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Źródło :
Nature medicine [Nat Med] 2005 Sep; Vol. 11 (9), pp. 973-81. Date of Electronic Publication: 2005 Aug 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Calcium Signaling*/drug effects
Astrocytes/*physiology
Epilepsy/*physiopathology
Glutamic Acid/*metabolism
Action Potentials/drug effects ; Animals ; Anticonvulsants/pharmacology ; Astrocytes/drug effects ; Hippocampus ; Photolysis ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Astrocyte-mediated activation of neuronal kainate receptors.
Autorzy :
Liu QS; Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10595, USA. />Xu Q
Arcuino G
Kang J
Nedergaard M
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2004 Mar 02; Vol. 101 (9), pp. 3172-7. Date of Electronic Publication: 2004 Feb 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Astrocytes/*physiology
Calcium Signaling/*physiology
Egtazic Acid/*analogs & derivatives
Interneurons/*physiology
Neurons/*physiology
Receptors, Kainic Acid/*physiology
Animals ; Astrocytes/drug effects ; Chelating Agents/pharmacology ; Egtazic Acid/pharmacology ; Hippocampus/physiology ; In Vitro Techniques ; Isoquinolines/pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptors, AMPA/antagonists & inhibitors ; Receptors, AMPA/physiology ; Receptors, Kainic Acid/drug effects ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors ; Receptors, N-Methyl-D-Aspartate/physiology ; Tetrazoles/pharmacology
Czasopismo naukowe
Tytuł :
Intercellular calcium signaling mediated by point-source burst release of ATP.
Autorzy :
Arcuino G; Department of Cell Biology, Anatomy, and Pathology, New York Medical College, Valhalla, NY 10595, USA.
Lin JH
Takano T
Liu C
Jiang L
Gao Q
Kang J
Nedergaard M
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2002 Jul 23; Vol. 99 (15), pp. 9840-5. Date of Electronic Publication: 2002 Jul 03.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Adenosine Triphosphate/*metabolism
Astrocytes/*physiology
Calcium Signaling/*physiology
Cell Communication/*physiology
Endothelium, Vascular/*physiology
Respiratory Mucosa/*physiology
Animals ; Animals, Newborn ; Astrocytes/cytology ; Cells, Cultured ; Cerebral Cortex/cytology ; Humans ; Kinetics ; Rats ; Respiratory Mucosa/cytology ; Umbilical Veins
Czasopismo naukowe
Tytuł :
Astrocytes in the aging brain.
Autorzy :
Cotrina ML; Department of Anatomy and Cell Biology, New York Medical College, Valhalla, NY 10595, USA.
Nedergaard M
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Źródło :
Journal of neuroscience research [J Neurosci Res] 2002 Jan 01; Vol. 67 (1), pp. 1-10.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, P.H.S.; Review
MeSH Terms :
Aging/*metabolism
Astrocytes/*metabolism
Brain/*metabolism
Calcium Signaling/*physiology
Cell Communication/*physiology
Neurons/*metabolism
Aging/pathology ; Animals ; Astrocytes/cytology ; Brain/cytology ; Energy Metabolism/physiology ; Humans ; Neurons/cytology ; Synaptic Transmission/physiology
Czasopismo naukowe

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