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Tytuł :
Circadian control of brain glymphatic and lymphatic fluid flow.
Autorzy :
Hablitz LM; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, 14642, USA. .
Plá V; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Giannetto M; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Vinitsky HS; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Stæger FF; Center for Basic and Translational Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, 2200, Copenhagen, Denmark.
Metcalfe T; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Nguyen R; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Benrais A; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Nedergaard M; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, 14642, USA. Nedergaard@urmc.rochester.edu.; Center for Basic and Translational Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, 2200, Copenhagen, Denmark. Nedergaard@urmc.rochester.edu.
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Źródło :
Nature communications [Nat Commun] 2020 Sep 02; Vol. 11 (1), pp. 4411. Date of Electronic Publication: 2020 Sep 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Aquaporin 4/*metabolism
Cerebrospinal Fluid/*metabolism
Circadian Rhythm/*physiology
Glymphatic System/*metabolism
Animals ; Astrocytes/metabolism ; Brain/metabolism ; Cisterna Magna/metabolism ; Lymph Nodes/metabolism ; Mice
Czasopismo naukowe
Tytuł :
Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport in the Glymphatic System.
Autorzy :
Koundal S; Department of Anesthesiology, Yale School of Medicine, New Haven, CT, USA.
Elkin R; Departments of Computer Science/Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY, USA.
Nadeem S; Department of Medical Physics, Memorial Sloan Kettering Cancer Center, NY, NY, USA.
Xue Y; Department of Anesthesiology, Yale School of Medicine, New Haven, CT, USA.
Constantinou S; Department of Anesthesiology, Yale School of Medicine, New Haven, CT, USA.
Sanggaard S; Department of Anesthesiology, Yale School of Medicine, New Haven, CT, USA.
Liu X; Department of Anesthesiology, Yale School of Medicine, New Haven, CT, USA.
Monte B; Department of Anesthesiology, Yale School of Medicine, New Haven, CT, USA.
Xu F; George & Anne Ryan Institute for Neuroscience, Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Rhode Island, RI, USA.
Van Nostrand W; George & Anne Ryan Institute for Neuroscience, Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Rhode Island, RI, USA.
Nedergaard M; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, USA.
Lee H; Department of Anesthesiology, Yale School of Medicine, New Haven, CT, USA.
Wardlaw J; Brain Research Imaging Centre, Centre for Clinical Brain Sciences, Dementia Research Institute at the University of Edinburgh, Edinburgh, United Kingdom.
Benveniste H; Department of Anesthesiology, Yale School of Medicine, New Haven, CT, USA.
Tannenbaum A; Departments of Computer Science/Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 Feb 06; Vol. 10 (1), pp. 1990. Date of Electronic Publication: 2020 Feb 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Models, Neurological*
Cerebral Small Vessel Diseases/*pathology
Cerebrospinal Fluid/*metabolism
Glymphatic System/*metabolism
Neuropil/*metabolism
Animals ; Cerebral Small Vessel Diseases/diagnosis ; Diffusion ; Disease Models, Animal ; Extracellular Fluid/metabolism ; Female ; Glymphatic System/diagnostic imaging ; Glymphatic System/pathology ; Humans ; Hydrodynamics ; Magnetic Resonance Imaging ; Male ; Rats
Czasopismo naukowe
Tytuł :
In Vivo Imaging of Cerebrospinal Fluid Transport through the Intact Mouse Skull using Fluorescence Macroscopy.
Autorzy :
Sweeney AM; Center for Translational Neuromedicine, University of Rochester Medical Center.
Plá V; Center for Translational Neuromedicine, University of Rochester Medical Center.
Du T; Center for Translational Neuromedicine, University of Rochester Medical Center.
Liu G; Center for Translational Neuromedicine, University of Rochester Medical Center.
Sun Q; Center for Translational Neuromedicine, University of Rochester Medical Center.
Peng S; Center for Translational Neuromedicine, University of Rochester Medical Center.
Plog BA; Center for Translational Neuromedicine, University of Rochester Medical Center.
Kress BT; Center for Translational Neuromedicine, University of Rochester Medical Center.
Wang X; Center for Translational Neuromedicine, University of Rochester Medical Center.
Mestre H; Center for Translational Neuromedicine, University of Rochester Medical Center; .
Nedergaard M; Center for Translational Neuromedicine, University of Rochester Medical Center; Center for Translational Neuromedicine, University of Copenhagen; .
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Źródło :
Journal of visualized experiments : JoVE [J Vis Exp] 2019 Jul 29 (149). Date of Electronic Publication: 2019 Jul 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms :
Brain/*physiology
Cerebrospinal Fluid/*physiology
Glymphatic System/*physiology
Imaging, Three-Dimensional/*instrumentation
Animals ; Brain/diagnostic imaging ; Cerebrospinal Fluid/diagnostic imaging ; Glymphatic System/diagnostic imaging ; Imaging, Three-Dimensional/methods ; Mice ; Microscopy, Fluorescence ; Skull
Czasopismo naukowe
Tytuł :
Hydraulic resistance of periarterial spaces in the brain.
Autorzy :
Tithof J; Department of Mechanical Engineering, University of Rochester, Rochester, NY, 14627, USA.
Kelley DH; Department of Mechanical Engineering, University of Rochester, Rochester, NY, 14627, USA.
Mestre H; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Nedergaard M; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Thomas JH; Department of Mechanical Engineering, University of Rochester, Rochester, NY, 14627, USA. .
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Źródło :
Fluids and barriers of the CNS [Fluids Barriers CNS] 2019 Jun 20; Vol. 16 (1), pp. 19. Date of Electronic Publication: 2019 Jun 20.
Typ publikacji :
Journal Article
MeSH Terms :
Models, Biological*
Cerebral Arteries/*physiology
Cerebrospinal Fluid/*physiology
Glymphatic System/*physiology
Pia Mater/*physiology
Brain/blood supply ; Brain/physiology ; Humans ; Pia Mater/blood supply
Czasopismo naukowe
Tytuł :
Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension.
Autorzy :
Mestre H; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, 14642, USA.; Department of Neuroscience, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Tithof J; Department of Mechanical Engineering, University of Rochester, Rochester, NY, 14627, USA.
Du T; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, 14642, USA.; China Medical University, Shenyang, 110122, China.
Song W; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Peng W; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, 14642, USA.; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200, Copenhagen, Denmark.
Sweeney AM; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Olveda G; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Thomas JH; Department of Mechanical Engineering, University of Rochester, Rochester, NY, 14627, USA.
Nedergaard M; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, 14642, USA.; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200, Copenhagen, Denmark.
Kelley DH; Department of Mechanical Engineering, University of Rochester, Rochester, NY, 14627, USA. .
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Źródło :
Nature communications [Nat Commun] 2018 Nov 19; Vol. 9 (1), pp. 4878. Date of Electronic Publication: 2018 Nov 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Arteries/*diagnostic imaging
Cerebrospinal Fluid/*diagnostic imaging
Cisterna Magna/*diagnostic imaging
Glymphatic System/*diagnostic imaging
Pulse Wave Analysis/*methods
Animals ; Arteries/physiology ; Cerebrospinal Fluid/physiology ; Cisterna Magna/anatomy & histology ; Cisterna Magna/physiology ; Fluorescent Dyes/chemistry ; Glymphatic System/anatomy & histology ; Glymphatic System/physiology ; Heart Rate/physiology ; Image Processing, Computer-Assisted ; Male ; Mice ; Mice, Inbred C57BL ; Microscopy, Confocal ; Microscopy, Fluorescence, Multiphoton/instrumentation ; Microscopy, Fluorescence, Multiphoton/methods ; Microspheres ; Particle Size ; Pulsatile Flow/physiology ; Pulse Wave Analysis/instrumentation ; Rheology/instrumentation ; Rheology/methods
Czasopismo naukowe
Tytuł :
Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain.
Autorzy :
Plog BA; Center for Translational Neuromedicine, Department of Neurosurgery.; Department of Pathology, and.
Mestre H; Center for Translational Neuromedicine, Department of Neurosurgery.; Department of Neuroscience, University of Rochester Medical Center, Rochester, New York, USA.
Olveda GE; Center for Translational Neuromedicine, Department of Neurosurgery.
Sweeney AM; Center for Translational Neuromedicine, Department of Neurosurgery.
Kenney HM; Center for Translational Neuromedicine, Department of Neurosurgery.
Cove A; Center for Translational Neuromedicine, Department of Neurosurgery.
Dholakia KY; Center for Translational Neuromedicine, Department of Neurosurgery.
Tithof J; Department of Mechanical Engineering and.
Nevins TD; Department of Physics and Astronomy, University of Rochester, Rochester, New York, USA.
Lundgaard I; Center for Translational Neuromedicine, Department of Neurosurgery.
Du T; Center for Translational Neuromedicine, Department of Neurosurgery.; Laboratory of Metabolic Brain Diseases, Institute of Metabolic Disease Research and Drug Development, China Medical University, Shenyang, China.
Kelley DH; Department of Mechanical Engineering and.
Nedergaard M; Center for Translational Neuromedicine, Department of Neurosurgery.; Department of Neuroscience, University of Rochester Medical Center, Rochester, New York, USA.
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Źródło :
JCI insight [JCI Insight] 2018 Oct 18; Vol. 3 (20). Date of Electronic Publication: 2018 Oct 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Alzheimer Disease/*drug therapy
Amyloid beta-Peptides/*antagonists & inhibitors
Cerebrospinal Fluid/*metabolism
Glymphatic System/*metabolism
Immunotherapy/*methods
Alzheimer Disease/pathology ; Animals ; Blood-Brain Barrier/metabolism ; Disease Models, Animal ; Fluorescent Dyes/administration & dosage ; Fluorescent Dyes/pharmacokinetics ; Glymphatic System/diagnostic imaging ; Glymphatic System/drug effects ; Humans ; Immunologic Factors/administration & dosage ; Immunologic Factors/pharmacokinetics ; Injections, Intraventricular ; Intravital Microscopy ; Male ; Mannitol/administration & dosage ; Mice ; Optical Imaging ; Osmolar Concentration ; Permeability/drug effects ; Plasma/chemistry ; Plasma/drug effects ; Saline Solution, Hypertonic/administration & dosage
Czasopismo naukowe
Tytuł :
Voluntary running enhances glymphatic influx in awake behaving, young mice.
Autorzy :
von Holstein-Rathlou S; Center for Translational Neuromedicine, University of Copenhagen, 2200 Copenhagen, Denmark. Electronic address: nedergaard@sund.ku.dk.
Petersen NC; Center for Translational Neuromedicine, University of Copenhagen, 2200 Copenhagen, Denmark.
Nedergaard M; Center for Translational Neuromedicine, University of Copenhagen, 2200 Copenhagen, Denmark; Center for Translational Neuromedicine, Division of Glial Disease and Therapeutics, University of Rochester Medical Center, Rochester, New York 14642, USA.
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Źródło :
Neuroscience letters [Neurosci Lett] 2018 Jan 01; Vol. 662, pp. 253-258. Date of Electronic Publication: 2017 Oct 25.
Typ publikacji :
Journal Article
MeSH Terms :
Brain/*physiology
Cerebrospinal Fluid/*physiology
Physical Conditioning, Animal/*physiology
Animals ; Female ; Mice ; Mice, Inbred C57BL ; Wakefulness
Czasopismo naukowe
Tytuł :
Glymphatic clearance controls state-dependent changes in brain lactate concentration.
Autorzy :
Lundgaard I; 1 Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester, Rochester, NY, USA.
Lu ML; 1 Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester, Rochester, NY, USA.; 2 Medical Research Council Laboratory for Molecular Cell Biology, University College London, London, UK.
Yang E; 1 Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester, Rochester, NY, USA.
Peng W; 1 Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester, Rochester, NY, USA.
Mestre H; 1 Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester, Rochester, NY, USA.
Hitomi E; 1 Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester, Rochester, NY, USA.
Deane R; 1 Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester, Rochester, NY, USA.
Nedergaard M; 1 Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester, Rochester, NY, USA.; 3 Center for Basic and Translational Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
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Źródło :
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2017 Jun; Vol. 37 (6), pp. 2112-2124. Date of Electronic Publication: 2016 Jan 01.
Typ publikacji :
Journal Article
MeSH Terms :
Brain/*metabolism
Cerebrospinal Fluid/*metabolism
Lactic Acid/*metabolism
Lymphatic System/*metabolism
Sleep/*physiology
Wakefulness/*physiology
Animals ; Aquaporin 4/genetics ; Electroencephalography ; Female ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Microdialysis
Czasopismo naukowe
Tytuł :
Cerebrospinal and interstitial fluid transport via the glymphatic pathway modeled by optimal mass transport.
Autorzy :
Ratner V; Department of Computer Science, Stony Brook University, Stony Brook, NY 11790, USA.
Gao Y; Department of Biomedical Informatics, Stony Brook University, Stony Brook, NY 11790, USA.
Lee H; Department of Anesthesiology, Yale School of Medicine, New Haven, CT 06519, USA.
Elkin R; Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY 11790, USA.
Nedergaard M; School of Medicine, Rochester University, NY 14642, USA.
Benveniste H; Department of Anesthesiology, Yale School of Medicine, New Haven, CT 06519, USA.
Tannenbaum A; Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY 11790, USA; Department of Computer Science, Stony Brook University, Stony Brook, NY 11790, USA. Electronic address: .
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Źródło :
NeuroImage [Neuroimage] 2017 May 15; Vol. 152, pp. 530-537. Date of Electronic Publication: 2017 Mar 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Brain/*metabolism
Brain Mapping/*methods
Cerebrospinal Fluid/*metabolism
Animals ; Biological Transport ; Brain/blood supply ; Female ; Magnetic Resonance Imaging ; Rats
Czasopismo naukowe
Tytuł :
Impairment of the glymphatic system after diabetes.
Autorzy :
Jiang Q; 1 Departments of Neurology, Henry Ford Health System, Detroit, MI, USA.; 2 Department of Physics, Oakland University, Rochester, MI, USA.
Zhang L; 1 Departments of Neurology, Henry Ford Health System, Detroit, MI, USA.
Ding G; 1 Departments of Neurology, Henry Ford Health System, Detroit, MI, USA.
Davoodi-Bojd E; 1 Departments of Neurology, Henry Ford Health System, Detroit, MI, USA.
Li Q; 1 Departments of Neurology, Henry Ford Health System, Detroit, MI, USA.
Li L; 1 Departments of Neurology, Henry Ford Health System, Detroit, MI, USA.
Sadry N; 1 Departments of Neurology, Henry Ford Health System, Detroit, MI, USA.
Nedergaard M; 3 Center for Translational Neuromedicine, University of Rochester, Rochester, NY, USA.; 4 Center for Basic and Translational Neuroscience, University of Copenhagen, Copenhagen, Denmark.
Chopp M; 1 Departments of Neurology, Henry Ford Health System, Detroit, MI, USA.; 2 Department of Physics, Oakland University, Rochester, MI, USA.
Zhang Z; 1 Departments of Neurology, Henry Ford Health System, Detroit, MI, USA.
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Źródło :
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2017 Apr; Vol. 37 (4), pp. 1326-1337. Date of Electronic Publication: 2016 Jan 01.
Typ publikacji :
Journal Article
MeSH Terms :
Brain/*diagnostic imaging
Cerebrospinal Fluid/*diagnostic imaging
Diabetes Mellitus, Experimental/*diagnostic imaging
Diabetes Mellitus, Type 2/*diagnostic imaging
Magnetic Resonance Imaging/*methods
Animals ; Brain/metabolism ; Cerebrospinal Fluid/metabolism ; Cluster Analysis ; Contrast Media ; Diabetes Mellitus, Experimental/cerebrospinal fluid ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Type 2/cerebrospinal fluid ; Diabetes Mellitus, Type 2/metabolism ; Extracellular Fluid/diagnostic imaging ; Extracellular Fluid/metabolism ; Gadolinium DTPA ; Male ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts.
Autorzy :
Wang M; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642.; Department of Neurology, Tongii Hospital, Tongii Medical College, Huazhong University of Science and Technology, Wuhan, China 430030.
Ding F; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642.; Department of Neurology, Tongii Hospital, Tongii Medical College, Huazhong University of Science and Technology, Wuhan, China 430030.
Deng S; Department of Neurology, Tongii Hospital, Tongii Medical College, Huazhong University of Science and Technology, Wuhan, China 430030.
Guo X; Department of Neurology, Tongii Hospital, Tongii Medical College, Huazhong University of Science and Technology, Wuhan, China 430030.
Wang W; Department of Neurology, Tongii Hospital, Tongii Medical College, Huazhong University of Science and Technology, Wuhan, China 430030.
Iliff JJ; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642, Nedergaard@URMC.Rochester.edu.; Department of Anesthesiology and Perioperative Medicine, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon 97239, and.
Nedergaard M; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642, Nedergaard@URMC.Rochester.edu.; Center for Basic and Translational Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark.
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2017 Mar 15; Vol. 37 (11), pp. 2870-2877. Date of Electronic Publication: 2017 Feb 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms :
Disease Models, Animal*
Signal Transduction*
Cerebral Arteries/*metabolism
Cerebrospinal Fluid/*metabolism
Extracellular Fluid/*metabolism
Myocardial Infarction/*cerebrospinal fluid
Animals ; Cerebral Arteries/pathology ; Cerebrospinal Fluid/cytology ; Extracellular Fluid/cytology ; Male ; Mice ; Mice, Inbred C57BL ; Myocardial Infarction/pathology
Czasopismo naukowe
Tytuł :
The Glymphatic System: A Beginner's Guide.
Autorzy :
Jessen NA; School of Medicine and Dentistry, University of Rochester Medical Center, 601 Elmwood Ave, Box 645, Rochester, NY, 14642, USA. .
Munk AS; School of Medicine and Dentistry, University of Rochester Medical Center, 601 Elmwood Ave, Box 645, Rochester, NY, 14642, USA.
Lundgaard I; School of Medicine and Dentistry, University of Rochester Medical Center, 601 Elmwood Ave, Box 645, Rochester, NY, 14642, USA.
Nedergaard M; School of Medicine and Dentistry, University of Rochester Medical Center, 601 Elmwood Ave, Box 645, Rochester, NY, 14642, USA.
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Źródło :
Neurochemical research [Neurochem Res] 2015 Dec; Vol. 40 (12), pp. 2583-99. Date of Electronic Publication: 2015 May 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Astrocytes/*metabolism
Cerebrospinal Fluid/*physiology
Lymphatic System/*metabolism
Aging/cerebrospinal fluid ; Animals ; Brain Injuries/cerebrospinal fluid ; Cerebrospinal Fluid/metabolism ; Humans
Czasopismo naukowe
Tytuł :
Implications of the discovery of brain lymphatic pathways.
Autorzy :
Iliff JJ; Department of Anesthesiology and Perioperative Medicine, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, OR, USA; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, USA.
Goldman SA; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, USA; Center for Basic and Translational Neuroscience, University of Copenhagen, Copenhagen, Denmark.
Nedergaard M; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, USA; Center for Basic and Translational Neuroscience, University of Copenhagen, Copenhagen, Denmark. Electronic address: nedergaard@urmc.rochester.edu.
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Źródło :
The Lancet. Neurology [Lancet Neurol] 2015 Oct; Vol. 14 (10), pp. 977-9.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Brain/*metabolism
Cerebrospinal Fluid/*metabolism
Extracellular Fluid/*metabolism
Lymph Nodes/*metabolism
Lymphatic System/*metabolism
Macromolecular Substances/*metabolism
Animals
Czasopismo naukowe
Tytuł :
Modern cerebrospinal fluid flow research and Heinrich Quincke's seminal 1872 article on the distribution of cinnabar in freely moving animals.
Autorzy :
Benveniste H; Departments of Anesthesiology and Radiology, University of Stony Brook, School of Medicine, Stony Brook, New York, 11794, USA.
Hof PR; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, 10029, USA.
Nedergaard M; Center for Translational Neuromedicine, University of Rochester Medical Center, School of Medicine, Rochester, New York, 14642, USA.
Bechter K; Department of Psychosomatics/Psychotherapy, Ulm University, D-89312, Günzburg, Germany.
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Źródło :
The Journal of comparative neurology [J Comp Neurol] 2015 Aug 15; Vol. 523 (12), pp. 1748-55. Date of Electronic Publication: 2015 May 12.
Typ publikacji :
Biography; Historical Article; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain/*metabolism
Cerebrospinal Fluid/*physiology
Neurology/*history
Spinal Cord/*metabolism
Animals ; Coloring Agents/administration & dosage ; Coloring Agents/pharmacokinetics ; History, 19th Century ; Mercury Compounds/administration & dosage ; Mercury Compounds/pharmacokinetics ; Motor Activity ; Tissue Distribution
Personal Name as Subject :
Quincke H
Czasopismo naukowe
Tytuł :
The Effect of Body Posture on Brain Glymphatic Transport.
Autorzy :
Lee H; Department of Anesthesiology, Department of Radiology, and.
Xie L; Center for Translational Neuromedicine, University of Rochester, Rochester, New York 14627.
Yu M; Department of Anesthesiology.
Kang H; Center for Translational Neuromedicine, University of Rochester, Rochester, New York 14627.
Feng T; Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, New York 11794.
Deane R; Center for Translational Neuromedicine, University of Rochester, Rochester, New York 14627.
Logan J; Department of Radiology, New York University Langone Medical Center, New York, New York 10016, and.
Nedergaard M; Center for Translational Neuromedicine, University of Rochester, Rochester, New York 14627.
Benveniste H; Department of Anesthesiology, Department of Radiology, and .
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2015 Aug 05; Vol. 35 (31), pp. 11034-44.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Amyloid beta-Peptides/*metabolism
Brain/*metabolism
Cerebrospinal Fluid/*metabolism
Posture/*physiology
Animals ; Biological Transport ; Female ; Magnetic Resonance Imaging ; Mice ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury.
Autorzy :
Iliff JJ; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642 and Department of Anesthesiology and Peri-Operative Medicine, and Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon 97239 .
Chen MJ; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642 and.
Plog BA; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642 and.
Zeppenfeld DM; Department of Anesthesiology and Peri-Operative Medicine, and Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon 97239.
Soltero M; Department of Anesthesiology and Peri-Operative Medicine, and.
Yang L; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642 and.
Singh I; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642 and.
Deane R; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642 and.
Nedergaard M; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642 and.
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2014 Dec 03; Vol. 34 (49), pp. 16180-93.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain Injuries/*metabolism
Brain Injuries/*pathology
Cerebrospinal Fluid/*metabolism
Extracellular Fluid/*metabolism
Neurofibrillary Tangles/*metabolism
Neurofibrillary Tangles/*pathology
tau Proteins/*metabolism
Animals ; Aquaporin 4/genetics ; Brain Injuries/complications ; Brain Injuries/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Nerve Degeneration/genetics ; Nerve Degeneration/metabolism ; Nerve Degeneration/pathology ; Neurofibrillary Tangles/genetics
Czasopismo naukowe
Tytuł :
Drowning stars: reassessing the role of astrocytes in brain edema.
Autorzy :
Thrane AS; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642, USA; Department of Ophthalmology, Haukeland University Hospital, Bergen 5021, Norway; Letten Centre, Institute of Basic Medical Sciences, Department of Physiology, University of Oslo, 0317 Oslo, Norway. Electronic address: .
Rangroo Thrane V; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642, USA; Department of Ophthalmology, Haukeland University Hospital, Bergen 5021, Norway; Letten Centre, Institute of Basic Medical Sciences, Department of Physiology, University of Oslo, 0317 Oslo, Norway.
Nedergaard M; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642, USA.
Pokaż więcej
Źródło :
Trends in neurosciences [Trends Neurosci] 2014 Nov; Vol. 37 (11), pp. 620-8. Date of Electronic Publication: 2014 Sep 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Astrocytes/*pathology
Brain/*metabolism
Brain Edema/*pathology
Cerebrospinal Fluid/*metabolism
Extracellular Fluid/*metabolism
Animals ; Astrocytes/metabolism ; Blood-Brain Barrier/metabolism ; Blood-Brain Barrier/pathology ; Brain/pathology ; Brain Edema/metabolism ; Humans
Czasopismo naukowe
Tytuł :
Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain.
Autorzy :
Iliff JJ; Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642, Department of Anesthesiology and Peri-Operative Medicine, Oregon Health & Science University, Portland, Oregon 97239, and Department of Neurology, Tongii Hospital, Tongii Medical College, Huazhong University of Science and Technology, Wuhan, China 430030.
Wang M
Zeppenfeld DM
Venkataraman A
Plog BA
Liao Y
Deane R
Nedergaard M
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2013 Nov 13; Vol. 33 (46), pp. 18190-9.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Blood Flow Velocity/*physiology
Brain/*blood supply
Brain/*physiology
Cerebral Arteries/*physiology
Cerebrospinal Fluid/*physiology
Animals ; Brain Chemistry/physiology ; Cerebral Arteries/chemistry ; Cerebrospinal Fluid/chemistry ; Extracellular Fluid/chemistry ; Extracellular Fluid/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Microscopy, Fluorescence, Multiphoton/methods
Czasopismo naukowe
Tytuł :
Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer.
Autorzy :
Yang L
Kress BT
Weber HJ
Thiyagarajan M
Wang B
Deane R
Benveniste H
Iliff JJ
Nedergaard M
Pokaż więcej
Źródło :
Journal of translational medicine [J Transl Med] 2013 May 01; Vol. 11, pp. 107. Date of Electronic Publication: 2013 May 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Injections, Spinal*
Molecular Probes*
Brain/*blood supply
Cerebrospinal Fluid/*metabolism
Animals ; Extracellular Fluid/metabolism ; Female ; Intracranial Pressure ; Lumbar Vertebrae/metabolism ; Male ; Mice, Inbred C57BL ; Molecular Weight ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.
Autorzy :
Iliff JJ; Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA. />Wang M
Liao Y
Plogg BA
Peng W
Gundersen GA
Benveniste H
Vates GE
Deane R
Goldman SA
Nagelhus EA
Nedergaard M
Pokaż więcej
Źródło :
Science translational medicine [Sci Transl Med] 2012 Aug 15; Vol. 4 (147), pp. 147ra111.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Amyloid beta-Peptides/*metabolism
Brain/*metabolism
Cerebrospinal Fluid/*metabolism
Extracellular Fluid/*metabolism
Animals ; Aquaporin 4/metabolism ; Astrocytes/metabolism ; Biological Transport ; Cerebral Ventricles/metabolism ; Imaging, Three-Dimensional ; Male ; Mice ; Mice, Inbred C57BL ; Microscopy, Fluorescence, Multiphoton ; Water/metabolism
Czasopismo naukowe

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