Temat: "Neoplasm Metastasis" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: GSDMD-dependent pyroptotic induction by a multivalent CXCR4-targeted nanotoxin blocks colorectal cancer metastases.
Autorzy:: Sala R; Biomedical Research Institute Sant Pau (IIB-Sant Pau), Barcelona, Spain.; CIBER en Bioingeniería, Biomateriales Y Nanomedicina (CIBER-BBN), Madrid, Spain.; Josep Carreras Research Institute, Barcelona, Spain.
Rioja-Blanco E; Biomedical Research Institute Sant Pau (IIB-Sant Pau), Barcelona, Spain.; Josep Carreras Research Institute, Barcelona, Spain.
Serna N; CIBER en Bioingeniería, Biomateriales Y Nanomedicina (CIBER-BBN), Madrid, Spain.; Institut de Biotecnologia I de Biomedicina, Universitat Autònoma de Barcelona, Bellaterra, Spain.; Departament de Genètica I de Microbiologia, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Sánchez-García L; CIBER en Bioingeniería, Biomateriales Y Nanomedicina (CIBER-BBN), Madrid, Spain.; Institut de Biotecnologia I de Biomedicina, Universitat Autònoma de Barcelona, Bellaterra, Spain.; Departament de Genètica I de Microbiologia, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Álamo P; Biomedical Research Institute Sant Pau (IIB-Sant Pau), Barcelona, Spain.; CIBER en Bioingeniería, Biomateriales Y Nanomedicina (CIBER-BBN), Madrid, Spain.; Josep Carreras Research Institute, Barcelona, Spain.
Alba-Castellón L; Biomedical Research Institute Sant Pau (IIB-Sant Pau), Barcelona, Spain.; Josep Carreras Research Institute, Barcelona, Spain.
Casanova I; Biomedical Research Institute Sant Pau (IIB-Sant Pau), Barcelona, Spain.; CIBER en Bioingeniería, Biomateriales Y Nanomedicina (CIBER-BBN), Madrid, Spain.; Josep Carreras Research Institute, Barcelona, Spain.
López-Pousa A; CIBER en Bioingeniería, Biomateriales Y Nanomedicina (CIBER-BBN), Madrid, Spain.; Department of Medical Oncology, Hospital de la Santa Creu I Sant Pau, Barcelon, Spain.
Unzueta U; Biomedical Research Institute Sant Pau (IIB-Sant Pau), Barcelona, Spain.; CIBER en Bioingeniería, Biomateriales Y Nanomedicina (CIBER-BBN), Madrid, Spain.; Josep Carreras Research Institute, Barcelona, Spain.
Céspedes MV; Biomedical Research Institute Sant Pau (IIB-Sant Pau), Barcelona, Spain.
Vázquez E; CIBER en Bioingeniería, Biomateriales Y Nanomedicina (CIBER-BBN), Madrid, Spain.; Institut de Biotecnologia I de Biomedicina, Universitat Autònoma de Barcelona, Bellaterra, Spain.; Departament de Genètica I de Microbiologia, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Villaverde A; CIBER en Bioingeniería, Biomateriales Y Nanomedicina (CIBER-BBN), Madrid, Spain.; Institut de Biotecnologia I de Biomedicina, Universitat Autònoma de Barcelona, Bellaterra, Spain.; Departament de Genètica I de Microbiologia, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Mangues R; Biomedical Research Institute Sant Pau (IIB-Sant Pau), Barcelona, Spain.; CIBER en Bioingeniería, Biomateriales Y Nanomedicina (CIBER-BBN), Madrid, Spain.; Josep Carreras Research Institute, Barcelona, Spain.; Pokaż więcej
Źródło:: Drug delivery [Drug Deliv] 2022 Dec; Vol. 29 (1), pp. 1384-1397.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents*/pharmacology
Colorectal Neoplasms*/drug therapy
Phosphate-Binding Proteins*/metabolism
Pore Forming Cytotoxic Proteins*/metabolism
Pyroptosis*
Receptors, CXCR4*/metabolism
Receptors, CXCR4*/therapeutic use
Drug Delivery Systems ; Humans ; Neoplasm Metastasis/prevention & control ; Signal Transduction

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Skocz do pozycji: 2.

Tytuł:: Prevention of New Metastatic Lesions by Eribulin Monotherapy Is Associated with Better Prognosis in Patients with Metastatic Breast Cancer.
Autorzy:: Hara Y; Department of Breast and Endocrine Surgery, Nihon University School of Medicine.
Fukumoto S; Department of Breast and Endocrine Surgery, Nihon University School of Medicine.
Mori S; Department of Breast and Endocrine Surgery, Nihon University School of Medicine.
Goto H; Department of Breast and Endocrine Surgery, Nihon University School of Medicine.
Matsumoto K; Department of Breast and Endocrine Surgery, Nihon University School of Medicine.
Enomoto K; Department of Breast and Endocrine Surgery, Nihon University School of Medicine.
Tada K; Department of Breast and Endocrine Surgery, Nihon University School of Medicine.; Pokaż więcej
Źródło:: Journal of Nippon Medical School = Nippon Ika Daigaku zasshi [J Nippon Med Sch] 2022 Nov 09; Vol. 89 (5), pp. 494-499. Date of Electronic Publication: 2022 May 30.
Typ publikacji:: Review; Journal Article
MeSH Terms:: Breast Neoplasms*/drug therapy
Breast Neoplasms*/pathology
Antineoplastic Agents*/therapeutic use
Humans ; Female ; Treatment Outcome ; Furans/therapeutic use ; Ketones/therapeutic use ; Prognosis ; Neoplasm Metastasis

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Skocz do pozycji: 3.

Tytuł:: A novel oncotherapy strategy: Direct thrombin inhibitors suppress progression, dissemination and spontaneous metastasis in non-small cell lung cancer.
Autorzy:: Zhao B; Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Fudan University, Shanghai, China.; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Wu M; Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Fudan University, Shanghai, China.; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Hu Z; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.; Department of Medical Oncology, Shanghai Cancer Center, Fudan University, Shanghai, China.
Wang T; Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Fudan University, Shanghai, China.; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Yu J; Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Fudan University, Shanghai, China.
Ma Y; Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Fudan University, Shanghai, China.; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Wang Q; Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Fudan University, Shanghai, China.; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Zhang Y; Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Fudan University, Shanghai, China.; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Chen D; Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Fudan University, Shanghai, China.; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Li T; Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Fudan University, Shanghai, China.; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Li Y; Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Fudan University, Shanghai, China.; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Yu M; Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Fudan University, Shanghai, China.; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Wang H; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.; Department of Medical Oncology, Shanghai Cancer Center, Fudan University, Shanghai, China.
Mo W; Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Fudan University, Shanghai, China.; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2022 Nov; Vol. 179 (22), pp. 5056-5073. Date of Electronic Publication: 2021 Feb 27.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antineoplastic Agents*
Carcinoma, Non-Small-Cell Lung*/drug therapy
Lung Neoplasms*/drug therapy
Lung Neoplasms*/secondary
Animals ; Antithrombins ; Fibrinolytic Agents ; Hirudins/pharmacology ; Interleukin-6 ; Matrix Metalloproteinase 9 ; Mice ; NF-kappa B ; Neoplasm Metastasis ; Thrombin

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Skocz do pozycji: 4.

Tytuł:: Prognostic role of docetaxel-induced suppression of free testosterone serum levels in metastatic prostate cancer patients.
Autorzy:: Kappler P; Department of Hematology, Hemostaseology, Oncology, and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Morgan MA; Institute of Experimental Hematology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Ivanyi P; Department of Hematology, Hemostaseology, Oncology, and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Brunotte SJ; Department of Hematology, Hemostaseology, Oncology, and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Ganser A; Department of Hematology, Hemostaseology, Oncology, and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Reuter CWM; Department of Hematology, Hemostaseology, Oncology, and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2021 Aug 12; Vol. 11 (1), pp. 16457. Date of Electronic Publication: 2021 Aug 12.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Neoplasm Metastasis*
Antineoplastic Agents/*therapeutic use
Docetaxel/*therapeutic use
Prostatic Neoplasms/*drug therapy
Testosterone/*blood
Aged ; Humans ; Limit of Detection ; Male ; Prognosis ; Prostate-Specific Antigen/blood ; Prostatic Neoplasms/blood ; Prostatic Neoplasms/pathology

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Skocz do pozycji: 5.

Tytuł:: Tumor growth inhibition modeling of individual lesion dynamics and interorgan variability in HER2-negative breast cancer patients treated with docetaxel.
Autorzy:: Krishnan SM; Department of Pharmacy, Uppsala University, Uppsala, Sweden.
Laarif SS; Department of Pharmacy, Uppsala University, Uppsala, Sweden.
Bender BC; Genentech Inc., San Francisco, California, USA.
Quartino AL; Genentech Inc., San Francisco, California, USA.
Friberg LE; Department of Pharmacy, Uppsala University, Uppsala, Sweden.; Pokaż więcej
Źródło:: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2021 May; Vol. 10 (5), pp. 511-521. Date of Electronic Publication: 2021 May 02.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Neoplasm Metastasis*
Patient-Specific Modeling*
Antineoplastic Agents/*therapeutic use
Breast Neoplasms/*drug therapy
Docetaxel/*therapeutic use
Receptor, ErbB-2/*metabolism
Adult ; Aged ; Aged, 80 and over ; Antineoplastic Agents/pharmacology ; Breast Neoplasms/pathology ; Docetaxel/pharmacology ; Female ; Humans ; Middle Aged

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Skocz do pozycji: 6.

Tytuł:: Antimetastatic and Antitumor Activities of Orally Administered NAX014 Compound in a Murine Model of HER2-Positive Breast Cancer.
Autorzy:: Pierpaoli E; Advanced Technology Center for Aging Research, Scientific Technological Area, IRCCS INRCA, 60121 Ancona, Italy.
Piacenza F; Advanced Technology Center for Aging Research, Scientific Technological Area, IRCCS INRCA, 60121 Ancona, Italy.
Fiorillo G; Naxospharma Srl, 20026 Novate Milanese, Italy.
Lombardi P; Naxospharma Srl, 20026 Novate Milanese, Italy.
Orlando F; Experimental Animal Models for Aging Unit, Scientific Technological Area, IRCCS INRCA, 60121 Ancona, Italy.
Salvatore C; Aesis Therapeutics Srl, Incubatore JCube, 60035 Jesi, Italy.
Geroni C; Aesis Therapeutics Srl, Incubatore JCube, 60035 Jesi, Italy.
Provinciali M; Advanced Technology Center for Aging Research, Scientific Technological Area, IRCCS INRCA, 60121 Ancona, Italy.; Experimental Animal Models for Aging Unit, Scientific Technological Area, IRCCS INRCA, 60121 Ancona, Italy.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Mar 06; Vol. 22 (5). Date of Electronic Publication: 2021 Mar 06.
Typ publikacji:: Journal Article
MeSH Terms:: Genes, erbB-2*
Antineoplastic Agents/*therapeutic use
Berberine Alkaloids/*therapeutic use
Mammary Neoplasms, Experimental/*prevention & control
Neoplasm Metastasis/*prevention & control
Administration, Oral ; Animals ; Antineoplastic Agents/administration & dosage ; Berberine Alkaloids/administration & dosage ; Berberine Alkaloids/chemistry ; Cell Cycle Checkpoints/drug effects ; Cell Line, Tumor ; Cell Movement/drug effects ; Drug Screening Assays, Antitumor ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Mammary Neoplasms, Experimental/drug therapy ; Mammary Neoplasms, Experimental/genetics ; Mice ; Mice, Transgenic ; Molecular Structure ; Neoplasm Metastasis/drug therapy ; Neoplasm Proteins/biosynthesis ; Neoplasm Proteins/genetics ; Rats ; Tumor Burden/drug effects

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Skocz do pozycji: 7.

Tytuł:: The management of metastatic GIST: current standard and investigational therapeutics.
Autorzy:: Kelly CM; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, USA. .; Department of Medicine, Weill Cornell Medical College, New York, USA. .
Gutierrez Sainz L; Department of Medical Oncology, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain.
Chi P; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, USA.; Department of Medicine, Weill Cornell Medical College, New York, USA.; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, USA.; Pokaż więcej
Źródło:: Journal of hematology & oncology [J Hematol Oncol] 2021 Jan 05; Vol. 14 (1), pp. 2. Date of Electronic Publication: 2021 Jan 05.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Antineoplastic Agents/*therapeutic use
Gastrointestinal Neoplasms/*drug therapy
Gastrointestinal Stromal Tumors/*drug therapy
Imatinib Mesylate/*therapeutic use
Neoplasm Metastasis/*drug therapy
Protein Kinase Inhibitors/*therapeutic use
Animals ; Disease Management ; Gastrointestinal Neoplasms/pathology ; Gastrointestinal Stromal Tumors/pathology ; Humans ; Neoplasm Metastasis/pathology ; Phenylurea Compounds/therapeutic use ; Pyridines/therapeutic use ; Sunitinib/therapeutic use

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Skocz do pozycji: 8.

Tytuł:: A Novel Small Molecular Prostaglandin Receptor EP4 Antagonist, L001, Suppresses Pancreatic Cancer Metastasis.
Autorzy:: He J; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Lin X; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Meng F; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China.
Zhao Y; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Wang W; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Zhang Y; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Chai X; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Zhang Y; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Yu W; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Yang J; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Li G; Department of Radiation Oncology, Fudan University Shanghai Cancer Center, 270 Dong'an Road, Shanghai 200032, China.
Du X; Department of Respiratory Medicine, Ningbo No. 2 Hospital, No. 41, Northwestern Street, Ningbo 315099, China.
Zhang H; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Liu M; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Lu W; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2022 Feb 11; Vol. 27 (4). Date of Electronic Publication: 2022 Feb 11.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents/*pharmacology
Pancreatic Neoplasms/*metabolism
Pancreatic Neoplasms/*pathology
Receptors, Prostaglandin E, EP4 Subtype/*antagonists & inhibitors
Receptors, Prostaglandin E, EP4 Subtype/*chemistry
Animals ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Cell Movement/drug effects ; Dinoprostone/metabolism ; Dinoprostone/pharmacology ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Hippo Signaling Pathway/drug effects ; Humans ; Mice ; Models, Biological ; Molecular Structure ; Neoplasm Metastasis ; Pancreatic Neoplasms/drug therapy ; Signal Transduction/drug effects ; Xenograft Model Antitumor Assays

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Skocz do pozycji: 9.

Tytuł:: Corylin suppresses metastasis of breast cancer cells by modulating miR-34c/LINC00963 target.
Autorzy:: Liu S; Department of Oncology and Hematology, Luzhou People's Hospital , Luzhou, China.
Wang L; Hemodialysis Center, Jiangmen Wuyi Hospital of Traditional Chinese Medicine , Jiangmen, China.
Zhang R; Department of Nursing, Luzhou People's Hospital , Luzhou, China.; Pokaż więcej
Źródło:: The Libyan journal of medicine [Libyan J Med] 2021 Dec; Vol. 16 (1), pp. 1883224.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents/*pharmacology
Breast Neoplasms/*drug therapy
Breast Neoplasms/*genetics
Flavonoids/*pharmacology
MicroRNAs/*drug effects
Cell Line, Tumor ; Cell Movement/drug effects ; Down-Regulation/drug effects ; Epithelial-Mesenchymal Transition/drug effects ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Neoplasm Invasiveness/genetics ; Neoplasm Metastasis/drug therapy ; Neoplasm Metastasis/genetics

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Skocz do pozycji: 10.

Tytuł:: Molecular Mechanisms, Biomarkers and Emerging Therapies for Chemotherapy Resistant TNBC.
Autorzy:: Ferrari P; Unit of Oncology 1, Department of Medical and Oncological Area, Pisa University Hospital, 56126 Pisa, Italy.
Scatena C; Division of Pathology, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy.
Ghilli M; Unit of Breast Surgery, Breast Cancer Center, University Hospital of Pisa, 56126 Pisa, Italy.
Bargagna I; Unit of Medical Oncology, Department of Translational Research and New Technologies in Medicine, University of Pisa, 56126 Pisa, Italy.
Lorenzini G; Unit of Medical Oncology, Department of Translational Research and New Technologies in Medicine, University of Pisa, 56126 Pisa, Italy.
Nicolini A; Unit of Medical Oncology, Department of Translational Research and New Technologies in Medicine, University of Pisa, 56126 Pisa, Italy.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Jan 31; Vol. 23 (3). Date of Electronic Publication: 2022 Jan 31.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Biomarkers, Tumor*/antagonists & inhibitors
Biomarkers, Tumor*/metabolism
Neoplasm Proteins*/antagonists & inhibitors
Neoplasm Proteins*/metabolism
Triple Negative Breast Neoplasms*/drug therapy
Triple Negative Breast Neoplasms*/metabolism
Triple Negative Breast Neoplasms*/mortality
Triple Negative Breast Neoplasms*/pathology
Antineoplastic Agents/*therapeutic use
Drug Resistance, Neoplasm/*drug effects
Female ; Humans ; Neoplasm Metastasis

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Skocz do pozycji: 11.

Tytuł:: The influence of docetaxel schedule on treatment tolerability and efficacy in patients with metastatic breast cancer: a systematic review and meta-analysis of randomized controlled trials.
Autorzy:: van Eijk M; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands. .
Vermunt MAC; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.
van Werkhoven E; Department of Biometrics, The Netherlands Cancer Institute - Antoni van Leeuwenhoek, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.
Wilthagen EA; Scientific Information Service, The Netherlands Cancer Institute - Antoni van Leeuwenhoek, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.
Huitema ADR; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.; Department of Clinical Pharmacy, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX, Utrecht, the Netherlands.; Department of Pharmacology, Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS, Utrecht, the Netherlands.
Beijnen JH; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.; Division of Pharmacoepidemiology & Clinical Pharmacology, Science Faculty, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Heidelberglaan 8, 3584 CS, Utrecht, The Netherlands.; Pokaż więcej
Źródło:: BMC cancer [BMC Cancer] 2022 Jan 25; Vol. 22 (1), pp. 104. Date of Electronic Publication: 2022 Jan 25.
Typ publikacji:: Journal Article; Meta-Analysis; Systematic Review
MeSH Terms:: Antineoplastic Agents/*administration & dosage
Breast Neoplasms/*drug therapy
Docetaxel/*administration & dosage
Adult ; Aged ; Breast Neoplasms/pathology ; Drug Administration Schedule ; Female ; Humans ; Middle Aged ; Neoplasm Metastasis ; Randomized Controlled Trials as Topic ; Treatment Outcome

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Skocz do pozycji: 12.

Tytuł:: Gold (III) Derivatives in Colon Cancer Treatment.
Autorzy:: Gurba A; Department of Pharmacodynamics, Faculty of Pharmacy, Medical University of Warsaw, 02-097 Warsaw, Poland.
Taciak P; Department of Pharmacodynamics, Faculty of Pharmacy, Medical University of Warsaw, 02-097 Warsaw, Poland.
Sacharczuk M; Department of Pharmacodynamics, Faculty of Pharmacy, Medical University of Warsaw, 02-097 Warsaw, Poland.; Department of Genomics, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, 05-552 Magdalenka, Poland.
Młynarczuk-Biały I; Department for Histology and Embryology, Medical University of Warsaw, Chalubinskiego 5, 02-004 Warsaw, Poland.
Bujalska-Zadrożny M; Department of Pharmacodynamics, Faculty of Pharmacy, Medical University of Warsaw, 02-097 Warsaw, Poland.
Fichna J; Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, 92-215 Lodz, Poland.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Jan 10; Vol. 23 (2). Date of Electronic Publication: 2022 Jan 10.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Drug Development*/methods
Antineoplastic Agents/*chemistry
Antineoplastic Agents/*pharmacology
Colonic Neoplasms/*drug therapy
Coordination Complexes/*chemistry
Coordination Complexes/*pharmacology
Gold/*chemistry
Animals ; Antineoplastic Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biomarkers ; Clinical Studies as Topic ; Colonic Neoplasms/diagnosis ; Colonic Neoplasms/etiology ; Colonic Neoplasms/metabolism ; Combined Modality Therapy ; Coordination Complexes/therapeutic use ; Disease Management ; Disease Susceptibility ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Humans ; Molecular Structure ; Neoplasm Metastasis ; Neoplasm Staging ; Signal Transduction/drug effects ; Structure-Activity Relationship

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Skocz do pozycji: 13.

Tytuł:: Association of sunitinib concentration and clinical outcome in patients with metastatic renal cell carcinoma treated with a 2-week-on and 1-week-off schedule.
Autorzy:: Ito T; Department of Pharmacy, Kobe University Hospital, Kobe, Japan.
Yamamoto K; Department of Pharmacy, Kobe University Hospital, Kobe, Japan.
Furukawa J; Department of Urology, Kobe University Graduate School of Medicine, Kobe, Japan.
Harada K; Department of Urology, Kobe University Graduate School of Medicine, Kobe, Japan.
Fujisawa M; Department of Urology, Kobe University Graduate School of Medicine, Kobe, Japan.
Omura T; Department of Pharmacy, Kobe University Hospital, Kobe, Japan.
Yano I; Department of Pharmacy, Kobe University Hospital, Kobe, Japan.; Pokaż więcej
Źródło:: Journal of clinical pharmacy and therapeutics [J Clin Pharm Ther] 2022 Jan; Vol. 47 (1), pp. 81-88. Date of Electronic Publication: 2021 Oct 20.
Typ publikacji:: Journal Article; Observational Study
MeSH Terms:: Antineoplastic Agents/*blood
Antineoplastic Agents/*therapeutic use
Carcinoma, Renal Cell/*drug therapy
Kidney Neoplasms/*drug therapy
Sunitinib/*blood
Sunitinib/*therapeutic use
Aged ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Carcinoma, Renal Cell/pathology ; Drug Administration Schedule ; Female ; Humans ; Kidney Neoplasms/pathology ; Male ; Middle Aged ; Neoplasm Metastasis ; Patient Acuity ; Retrospective Studies ; Sunitinib/administration & dosage ; Sunitinib/adverse effects

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Skocz do pozycji: 14.

Tytuł:: Zebrafish-Based Screening Models for the Identification of Anti-Metastatic Drugs.
Autorzy:: Nakayama J; Shonai Regional Industry Promotion Center, Tsuruoka, Yamagata, 997-0052, Japan.; Tsuruoka Metabolomics Laboratory, National Cancer Center, Mizukami 246-2, Kakuganji, Tsuruoka, Yamagata 975-0052, Japan.
Makinoshima H; Tsuruoka Metabolomics Laboratory, National Cancer Center, Mizukami 246-2, Kakuganji, Tsuruoka, Yamagata 975-0052, Japan.; Division of Translational Research, Exploratory Oncology Research, and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba 277-8577, Japan.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2020 May 21; Vol. 25 (10). Date of Electronic Publication: 2020 May 21.
Typ publikacji:: Journal Article; Review
MeSH Terms:: High-Throughput Screening Assays*
Antineoplastic Agents/*pharmacology
Neoplasm Metastasis/*drug therapy
Neovascularization, Pathologic/*drug therapy
Animals ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Cell Movement/drug effects ; Disease Models, Animal ; Drug Screening Assays, Antitumor/methods ; Humans ; Neoplasm Invasiveness/genetics ; Neoplasm Invasiveness/pathology ; Neoplasm Metastasis/pathology ; Neovascularization, Pathologic/pathology ; Tumor Microenvironment/drug effects ; Zebrafish

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Skocz do pozycji: 15.

Tytuł:: A uracil auxotroph Toxoplasma gondii exerting immunomodulation to inhibit breast cancer growth and metastasis.
Autorzy:: Xu LQ; Department of Pathogen Biology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, Guangdong, 510515, People's Republic of China.
Yao LJ; Department of Pathogen Biology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, Guangdong, 510515, People's Republic of China.
Jiang D; Department of Pathogen Biology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, Guangdong, 510515, People's Republic of China.
Zhou LJ; Department of Pathogen Biology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, Guangdong, 510515, People's Republic of China.
Chen M; Department of Pathogen Biology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, Guangdong, 510515, People's Republic of China.
Liao WZ; Department of Pathogen Biology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, Guangdong, 510515, People's Republic of China.
Zou WH; Department of Pathogen Biology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, Guangdong, 510515, People's Republic of China.
Peng HJ; Department of Pathogen Biology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, Guangdong, 510515, People's Republic of China. .; Pokaż więcej
Źródło:: Parasites & vectors [Parasit Vectors] 2021 Dec 11; Vol. 14 (1), pp. 601. Date of Electronic Publication: 2021 Dec 11.
Typ publikacji:: Journal Article
MeSH Terms:: Immunomodulation*
Antineoplastic Agents/*immunology
Breast Neoplasms/*drug therapy
Toxoplasma/*immunology
Cytokines/metabolism ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Neoplasm Metastasis/prevention & control ; Uracil/metabolism

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Skocz do pozycji: 16.

Tytuł:: Population pharmacokinetics of liposomal irinotecan in patients with cancer and exposure-safety analyses in patients with metastatic pancreatic cancer.
Autorzy:: Brendel K; Ipsen, Les-Ulis, France.
Bekaii-Saab T; Mayo Clinic, Phoenix, Arizona, USA.
Boland PM; Roswell Park Cancer Institute, Buffalo, New York, USA.
Dayyani F; University of California Irvine, Orange, California, USA.
Dean A; St John of God Hospital Subiaco, Perth, Western Australia, Australia.
Macarulla T; Vall d´Hebrón University Hospital, Vall d´Hebrón Institute of Oncology, Barcelona, Spain.
Maxwell F; Ipsen, Abingdon, UK.
Mody K; Mayo Clinic, Jacksonville, Florida, USA.
Pedret-Dunn A; Ipsen, Abingdon, UK.
Wainberg ZA; Ronald Regan UCLA Medical Center, Los Angeles, California, USA.
Zhang B; Ipsen, Cambridge, Massachusetts, USA.; Pokaż więcej
Źródło:: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2021 Dec; Vol. 10 (12), pp. 1550-1563. Date of Electronic Publication: 2021 Nov 20.
Typ publikacji:: Clinical Trial, Phase I; Clinical Trial, Phase II; Clinical Trial, Phase III; Journal Article
MeSH Terms:: Antineoplastic Agents/*pharmacokinetics
Antineoplastic Agents/*therapeutic use
Carcinoma, Pancreatic Ductal/*drug therapy
Irinotecan/*pharmacokinetics
Irinotecan/*therapeutic use
Pancreatic Neoplasms/*drug therapy
Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Carcinoma, Pancreatic Ductal/pathology ; Diarrhea/chemically induced ; Female ; Genotype ; Glucuronosyltransferase/genetics ; Humans ; Irinotecan/administration & dosage ; Irinotecan/adverse effects ; Liposomes/chemistry ; Logistic Models ; Male ; Metabolic Clearance Rate ; Models, Biological ; Neoplasm Metastasis ; Neutropenia/chemically induced ; Pancreatic Neoplasms/pathology

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Skocz do pozycji: 17.

Tytuł:: Liver X receptors regulate natural killer T cell population and antitumor activity in the liver of mice.
Autorzy:: Endo-Umeda K; Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan.
Nakashima H; Department of Immunology and Microbiology, National Defense Medical College, Tokorozawa, Saitama, Japan.
Uno S; Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan.
Toyoshima S; Allergy and Immunology Research Project Team, Research Institute of Medical Science, Center for Institutional Research and Medical Education, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan.; Department of Biochemistry and Molecular Biology, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.
Umeda N; Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan.
Komine-Aizawa S; Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan.
Seki S; Department of Immunology and Microbiology, National Defense Medical College, Tokorozawa, Saitama, Japan.
Makishima M; Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2021 Nov 19; Vol. 11 (1), pp. 22595. Date of Electronic Publication: 2021 Nov 19.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antineoplastic Agents/*pharmacology
Killer Cells, Natural/*metabolism
Liver/*drug effects
Liver X Receptors/*metabolism
Animals ; Bone Marrow/metabolism ; Bone Marrow Transplantation ; Cytokines/metabolism ; Galactosylceramides/metabolism ; Leukocytes, Mononuclear/metabolism ; Liver/metabolism ; Liver Neoplasms/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neoplasm Metastasis ; Spleen/cytology ; Spleen/metabolism ; Thymocytes/cytology

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Skocz do pozycji: 18.

Tytuł:: Role of Cell-Free DNA and Deoxyribonucleases in Tumor Progression.
Autorzy:: Alekseeva L; Institute of Chemical Biology and Fundamental Medicine, SB RAS, Lavrentiev Ave., 8, 630090 Novosibirsk, Russia.
Mironova N; Institute of Chemical Biology and Fundamental Medicine, SB RAS, Lavrentiev Ave., 8, 630090 Novosibirsk, Russia.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Nov 12; Vol. 22 (22). Date of Electronic Publication: 2021 Nov 12.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Antineoplastic Agents/*metabolism
Cell-Free Nucleic Acids/*metabolism
Deoxyribonucleases/*metabolism
Extracellular Traps/*metabolism
Neoplasms/*metabolism
Neutrophils/*metabolism
Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; Cell-Free Nucleic Acids/blood ; Cell-Free Nucleic Acids/genetics ; Disease Progression ; Humans ; Neoplasm Metastasis ; Neoplasms/genetics ; Neoplasms/pathology

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Skocz do pozycji: 19.

Tytuł:: Heterogeneity of Cancer Stem Cells in Tumorigenesis, Metastasis, and Resistance to Antineoplastic Treatment of Head and Neck Tumours.
Autorzy:: Cirillo N; Melbourne Dental School, The University of Melbourne, Carlton, VIC 3053, Australia.
Wu C; Melbourne Dental School, The University of Melbourne, Carlton, VIC 3053, Australia.
Prime SS; Centre for Immunology and Regenerative Medicine, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London E1 4NS, UK.; Pokaż więcej
Źródło:: Cells [Cells] 2021 Nov 08; Vol. 10 (11). Date of Electronic Publication: 2021 Nov 08.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Drug Resistance, Neoplasm*/drug effects
Antineoplastic Agents/*therapeutic use
Carcinogenesis/*pathology
Head and Neck Neoplasms/*drug therapy
Head and Neck Neoplasms/*pathology
Neoplastic Stem Cells/*pathology
Animals ; Antineoplastic Agents/pharmacology ; Carcinogenesis/drug effects ; Humans ; Neoplasm Metastasis ; Neoplastic Stem Cells/drug effects

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Skocz do pozycji: 20.

Tytuł:: Efficacy and safety of anlotinib in patients with unresectable or metastatic bone sarcoma: A retrospective multiple institution study.
Autorzy:: Liu Z; Department of Orthopedics, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, Henan, China.
Gao S; Department of Orthopedics, Henan Provincial People's Hospital and People's Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Zhu L; Department of Orthopedics, Zhengzhou Orthopedics Hospital, Zhengzhou, Henan, China.
Wang J; Department of Orthopedics, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, Henan, China.
Zhang P; Department of Orthopedics, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, Henan, China.
Li P; Department of Orthopedics, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, Henan, China.
Zhang F; Department of Orthopedics, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, Henan, China.
Yao W; Department of Orthopedics, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, Henan, China.; Pokaż więcej
Źródło:: Cancer medicine [Cancer Med] 2021 Nov; Vol. 10 (21), pp. 7593-7600. Date of Electronic Publication: 2021 Sep 26.
Typ publikacji:: Journal Article; Multicenter Study
MeSH Terms:: Antineoplastic Agents/*adverse effects
Antineoplastic Agents/*therapeutic use
Bone Neoplasms/*drug therapy
Indoles/*adverse effects
Indoles/*therapeutic use
Osteosarcoma/*drug therapy
Protein-Tyrosine Kinases/*antagonists & inhibitors
Quinolines/*adverse effects
Quinolines/*therapeutic use
Adolescent ; Adult ; Aged ; Bone Neoplasms/pathology ; Humans ; Middle Aged ; Neoplasm Metastasis ; Osteosarcoma/pathology ; Progression-Free Survival ; Retrospective Studies ; Young Adult

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