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Tytuł :
A Phase I dose-escalation study of DCLL9718S, an antibody-drug conjugate targeting C-type lectin-like molecule-1 (CLL-1) in patients with acute myeloid leukemia.
Autorzy :
Daver N; Department of Leukemia, MD Anderson Cancer Center, Houston, Texas.
Salhotra A; City of Hope Comprehensive Cancer Center, Duarte, California.
Brandwein JM; University of Alberta Hospital, Edmonton, Alberta, Canada.
Podoltsev NA; Yale University School of Medicine, New Haven, Connecticut.
Pollyea DA; Division of Hematology, Department of Medicine, University of Colorado, Aurora, Colorado.
Jurcic JG; Columbia University Irving Medical Center, New York Presbyterian Hospital, and Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York.
Assouline S; Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
Yee K; Department of Medical Oncology, Princess Margaret Hospital, Toronto, Ontario, Canada.
Li M; Genentech, Inc., South San Francisco, California.
Pourmohamad T; Genentech, Inc., South San Francisco, California.
Samineni D; Genentech, Inc., South San Francisco, California.
Sumiyoshi T; Genentech, Inc., South San Francisco, California.
Vaze A; Genentech, Inc., South San Francisco, California.
Dere RC; Genentech, Inc., South San Francisco, California.
Ma C; Genentech, Inc., South San Francisco, California.
Cooper J; Genentech, Inc., South San Francisco, California.
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Źródło :
American journal of hematology [Am J Hematol] 2021 May 01; Vol. 96 (5), pp. E175-E179. Date of Electronic Publication: 2021 Mar 11.
Typ publikacji :
Clinical Trial, Phase I; Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies/*therapeutic use
Antineoplastic Agents/*therapeutic use
Chemical and Drug Induced Liver Injury/*etiology
Immunoconjugates/*therapeutic use
Lectins, C-Type/*antagonists & inhibitors
Leukemia, Myeloid, Acute/*drug therapy
Neoplasm Proteins/*antagonists & inhibitors
Receptors, Mitogen/*antagonists & inhibitors
Adult ; Aged ; Aged, 80 and over ; Antibodies/administration & dosage ; Antibodies/adverse effects ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Dose-Response Relationship, Drug ; Early Termination of Clinical Trials ; Female ; Humans ; Immunoconjugates/administration & dosage ; Immunoconjugates/adverse effects ; Lectins, C-Type/immunology ; Leukemia, Myeloid, Acute/genetics ; Male ; Middle Aged ; Mutation ; Neoplasm Proteins/genetics ; Neoplasm Proteins/immunology ; Neoplasms, Second Primary/drug therapy ; Neoplasms, Second Primary/genetics ; Receptors, Mitogen/immunology ; Young Adult
Raport
Tytuł :
Preferential Expression of Programmed Death Ligand 1 Protein in Tumor-Associated Macrophages and Its Potential Role in Immunotherapy for Hepatocellular Carcinoma.
Autorzy :
Park DJ; The Catholic University Liver Research Center, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Sung PS; The Catholic University Liver Research Center, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.; Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul 06591, Korea.
Lee GW; The Catholic University Liver Research Center, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Cho S; The Catholic University Liver Research Center, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Kim SM; The Catholic University Liver Research Center, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Kang BY; The Catholic University Liver Research Center, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Hur W; The Catholic University Liver Research Center, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Yang H; The Catholic University Liver Research Center, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.; Department of Internal Medicine, College of Medicine, Eunpyeong St. Mary's Hospital, The Catholic University of Korea, Seoul 03383, Korea.
Lee SK; The Catholic University Liver Research Center, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.; Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul 06591, Korea.
Lee SH; Department of Clinical Pathology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Jung ES; Department of Hospital Pathology, College of Medicine, Eunpyeong St. Mary's Hospital, The Catholic University of Korea, Seoul 03383, Korea.
Seo CH; Department of Surgery, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul 06591, Korea.
Ahn J; Department of Surgery, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul 06591, Korea.
Choi HJ; Department of Surgery, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul 06591, Korea.
You YK; Department of Surgery, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul 06591, Korea.
Jang JW; The Catholic University Liver Research Center, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.; Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul 06591, Korea.
Bae SH; The Catholic University Liver Research Center, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.; Department of Internal Medicine, College of Medicine, Eunpyeong St. Mary's Hospital, The Catholic University of Korea, Seoul 03383, Korea.
Choi JY; The Catholic University Liver Research Center, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.; Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul 06591, Korea.
Yoon SK; The Catholic University Liver Research Center, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.; Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul 06591, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 29; Vol. 22 (9). Date of Electronic Publication: 2021 Apr 29.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Immunological/*pharmacology
B7-H1 Antigen/*biosynthesis
Carcinoma, Hepatocellular/*immunology
Immune Checkpoint Inhibitors/*pharmacology
Immunotherapy/*methods
Liver Neoplasms/*immunology
Molecular Targeted Therapy/*methods
Neoplasm Proteins/*biosynthesis
Nivolumab/*pharmacology
Tumor Microenvironment/*immunology
Tumor-Associated Macrophages/*metabolism
Animals ; Antineoplastic Agents, Immunological/therapeutic use ; B7-H1 Antigen/antagonists & inhibitors ; B7-H1 Antigen/genetics ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/therapy ; Coculture Techniques ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Ki-67 Antigen/biosynthesis ; Ki-67 Antigen/genetics ; Liver Neoplasms/pathology ; Liver Neoplasms/therapy ; Liver Neoplasms, Experimental/immunology ; Lymphocytes, Tumor-Infiltrating/immunology ; Mice ; Mice, Inbred C57BL ; Neoplasm Proteins/antagonists & inhibitors ; Neoplasm Proteins/genetics ; Nivolumab/therapeutic use ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; Tumor Cells, Cultured ; Tumor-Associated Macrophages/drug effects
Czasopismo naukowe
Tytuł :
Human Endogenous Retrovirus (HERV)-K env Gene Knockout Affects Tumorigenic Characteristics of nupr1 Gene in DLD-1 Colorectal Cancer Cells.
Autorzy :
Ko EJ; Department of Parasitology and Genetics, Kosin University College of Medicine, Busan 49267, Korea.; Department of Biological Sciences, College of Natural Sciences, Pusan National University, Busan 46241, Korea.
Ock MS; Department of Parasitology and Genetics, Kosin University College of Medicine, Busan 49267, Korea.
Choi YH; Department of Biochemistry, College of Oriental Medicine, Dongeui University, Busan 47227, Korea.
Iovanna JL; Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, 163 Avenue de Luminy, 13288 Marseille, France.
Mun S; Department of Nanobiomedical Science, Dankook University, Cheonan 31116, Korea.; Center for Bio-Medical Engineering Core Facility, Dankook University, Cheonan 31116, Korea.
Han K; Center for Bio-Medical Engineering Core Facility, Dankook University, Cheonan 31116, Korea.; Department of Microbiology, Dankook University, Cheonan 31116, Korea.
Kim HS; Department of Biological Sciences, College of Natural Sciences, Pusan National University, Busan 46241, Korea.
Cha HJ; Department of Parasitology and Genetics, Kosin University College of Medicine, Busan 49267, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 11; Vol. 22 (8). Date of Electronic Publication: 2021 Apr 11.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinogenesis*/genetics
Carcinogenesis*/metabolism
Carcinogenesis*/pathology
Colorectal Neoplasms*/genetics
Colorectal Neoplasms*/metabolism
Colorectal Neoplasms*/pathology
Endogenous Retroviruses*
Neoplasm Proteins*/genetics
Neoplasm Proteins*/metabolism
Nuclear Receptor Subfamily 4, Group A, Member 2*/genetics
Nuclear Receptor Subfamily 4, Group A, Member 2*/metabolism
Gene Products, env/*genetics
Gene Knockdown Techniques ; Gene Products, env/metabolism ; HCT116 Cells ; Humans
Czasopismo naukowe
Tytuł :
Bioassay-Guided Identification of the Antiproliferative Compounds of Cissus trifoliata and the Transcriptomic Effect of Resveratrol in Prostate Cancer Pc3 Cells.
Autorzy :
Méndez-López LF; Laboratorio de Química Farmacéutica, Facultad de Ciencias Químicas, Universidad Autónoma de Nuevo León, Ciudad Universitaria, San Nicolás de los Garza, Nuevo León 66451, Mexico.; Centro de Investigación en Nutrición y Salud Publica, Facultad de Salud Pública y Nutrición, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León 66460, Mexico.
Caboni P; Dipartamento Scienze della vita e dell'ambiente, Università degli Studi di Cagliari, Cittadella Universitaria, Monserrato, 09042 Cagliari, Italy.
Arredondo-Espinoza E; Laboratorio de Química Farmacéutica, Facultad de Ciencias Químicas, Universidad Autónoma de Nuevo León, Ciudad Universitaria, San Nicolás de los Garza, Nuevo León 66451, Mexico.
Carrizales-Castillo JJJ; Laboratorio de Química Farmacéutica, Facultad de Ciencias Químicas, Universidad Autónoma de Nuevo León, Ciudad Universitaria, San Nicolás de los Garza, Nuevo León 66451, Mexico.
Balderas-Rentería I; Laboratorio de Química Farmacéutica, Facultad de Ciencias Químicas, Universidad Autónoma de Nuevo León, Ciudad Universitaria, San Nicolás de los Garza, Nuevo León 66451, Mexico.
Camacho-Corona MDR; Laboratorio de Química Farmacéutica, Facultad de Ciencias Químicas, Universidad Autónoma de Nuevo León, Ciudad Universitaria, San Nicolás de los Garza, Nuevo León 66451, Mexico.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Apr 11; Vol. 26 (8). Date of Electronic Publication: 2021 Apr 11.
Typ publikacji :
Journal Article
MeSH Terms :
Transcriptome*
Antineoplastic Agents, Phytogenic/*chemistry
Cell Proliferation/*drug effects
Cissus/*chemistry
Neoplasm Proteins/*genetics
Antineoplastic Agents, Phytogenic/isolation & purification ; Antineoplastic Agents, Phytogenic/pharmacology ; Apigenin/chemistry ; Apigenin/isolation & purification ; Apigenin/pharmacology ; Biological Assay ; Cell Survival/drug effects ; Flavanones/chemistry ; Flavanones/isolation & purification ; Flavanones/pharmacology ; Flavones/chemistry ; Flavones/isolation & purification ; Flavones/pharmacology ; Gene Expression Profiling ; Humans ; Kaempferols/chemistry ; Kaempferols/isolation & purification ; Kaempferols/pharmacology ; Male ; Microarray Analysis ; Neoplasm Proteins/classification ; Neoplasm Proteins/metabolism ; PC-3 Cells ; Pentacyclic Triterpenes/chemistry ; Pentacyclic Triterpenes/isolation & purification ; Pentacyclic Triterpenes/pharmacology ; Plant Extracts/chemistry ; Resveratrol/chemistry ; Resveratrol/isolation & purification ; Resveratrol/pharmacology
Czasopismo naukowe
Tytuł :
Hereditary Prostate Cancer: Genes Related, Target Therapy and Prevention.
Autorzy :
Vietri MT; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Via L. De Crecchio, 80138 Naples, Italy.; U.O.C. Clinical and Molecular Pathology, A.O.U. University of Campania 'Luigi Vanvitelli', 80138 Naple, Italy.
D'Elia G; U.O.C. Clinical and Molecular Pathology, A.O.U. University of Campania 'Luigi Vanvitelli', 80138 Naple, Italy.
Caliendo G; U.O.C. Clinical and Molecular Pathology, A.O.U. University of Campania 'Luigi Vanvitelli', 80138 Naple, Italy.
Resse M; U.O.C. Clinical and Molecular Pathology, A.O.U. University of Campania 'Luigi Vanvitelli', 80138 Naple, Italy.
Casamassimi A; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Via L. De Crecchio, 80138 Naples, Italy.
Passariello L; U.O.C. Clinical and Molecular Pathology, A.O.U. University of Campania 'Luigi Vanvitelli', 80138 Naple, Italy.
Albanese L; U.O.C. Clinical and Molecular Pathology, A.O.U. University of Campania 'Luigi Vanvitelli', 80138 Naple, Italy.
Cioffi M; U.O.C. Clinical and Molecular Pathology, A.O.U. University of Campania 'Luigi Vanvitelli', 80138 Naple, Italy.
Molinari AM; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Via L. De Crecchio, 80138 Naples, Italy.; U.O.C. Clinical and Molecular Pathology, A.O.U. University of Campania 'Luigi Vanvitelli', 80138 Naple, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 04; Vol. 22 (7). Date of Electronic Publication: 2021 Apr 04.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Germ-Line Mutation*
Molecular Targeted Therapy*
Neoplasm Proteins*/genetics
Neoplasm Proteins*/metabolism
Prostatic Neoplasms*/genetics
Prostatic Neoplasms*/metabolism
Prostatic Neoplasms*/pathology
Prostatic Neoplasms*/prevention & control
Humans ; Male
SCR Disease Name :
Prostate cancer, familial
Czasopismo naukowe
Tytuł :
A first-generation pediatric cancer dependency map.
Autorzy :
Dharia NV; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.
Kugener G; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Guenther LM; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.
Malone CF; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.
Durbin AD; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.; Department of Oncology, Comprehensive Cancer Center, St. Jude Children's Research Hospital, Memphis, TN, USA.
Hong AL; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.; Department of Pediatrics, Emory University and Department of Hematology and Oncology, Children's Healthcare of Atlanta, Atlanta, GA, USA.
Howard TP; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Bandopadhayay P; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.
Wechsler CS; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.
Fung I; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Warren AC; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Dempster JM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Krill-Burger JM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Paolella BR; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Moh P; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; University of Maryland, College Park, MD, USA.
Jha N; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Tang A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Montgomery P; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Boehm JS; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Hahn WC; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Roberts CWM; Department of Oncology, Comprehensive Cancer Center, St. Jude Children's Research Hospital, Memphis, TN, USA.
McFarland JM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Tsherniak A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Golub TR; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.
Vazquez F; Broad Institute of MIT and Harvard, Cambridge, MA, USA. .; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. .
Stegmaier K; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. .; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA. .; Broad Institute of MIT and Harvard, Cambridge, MA, USA. .; Harvard Medical School, Boston, MA, USA. .
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Źródło :
Nature genetics [Nat Genet] 2021 Apr; Vol. 53 (4), pp. 529-538. Date of Electronic Publication: 2021 Mar 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Genome, Human*
Mutation*
Chromosome Mapping/*methods
Neoplasm Proteins/*genetics
Neoplasms/*genetics
Adult ; CRISPR-Associated Protein 9/genetics ; CRISPR-Associated Protein 9/metabolism ; CRISPR-Cas Systems ; Cell Line, Tumor ; Child ; Clustered Regularly Interspaced Short Palindromic Repeats ; Gene Editing ; Gene Expression Profiling ; Genetic Predisposition to Disease ; Humans ; Neoplasm Proteins/classification ; Neoplasm Proteins/metabolism ; Neoplasms/metabolism ; Neoplasms/pathology ; RNA, Guide/genetics ; RNA, Guide/metabolism
Czasopismo naukowe
Tytuł :
Prolidase - A protein with many faces.
Autorzy :
Wilk P; Malopolska Centre of Biotechnology, Jagiellonian University, ul. Gronostajowa 7a, 30-387 Krakow, Poland. Electronic address: .
Wątor E; Malopolska Centre of Biotechnology, Jagiellonian University, ul. Gronostajowa 7a, 30-387 Krakow, Poland.
Weiss MS; Macromolecular Crystallography, Helmholtz-Zentrum Berlin für Materialien und Energie, Albert-Einstein-Str. 15, 12489, Berlin, Germany.
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Źródło :
Biochimie [Biochimie] 2021 Apr; Vol. 183, pp. 3-12. Date of Electronic Publication: 2020 Oct 10.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Carcinogenesis*/genetics
Carcinogenesis*/metabolism
Dipeptidases*/genetics
Dipeptidases*/metabolism
Neoplasm Proteins*/genetics
Neoplasm Proteins*/metabolism
Neoplasms*/enzymology
Neoplasms*/genetics
Prolidase Deficiency*/enzymology
Prolidase Deficiency*/genetics
Animals ; Humans
Czasopismo naukowe
Tytuł :
Targeting constitutively active STAT3 in chronic lymphocytic leukemia: A clinical trial of the STAT3 inhibitor pyrimethamine with pharmacodynamic analyses.
Autorzy :
Brown JR; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Walker SR; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Heppler LN; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Tyekucheva S; Department of Data Sciences, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Nelson EA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Klitgaard J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Nicolais M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Kroll Y; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Xiang M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Yeh JE; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Chaudhury M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Giaccone ZT; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Fernandes SM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Jacobsen ED; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Fisher DC; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Freedman AS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Davids MS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Supko JG; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Wu C; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Frank DA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
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Źródło :
American journal of hematology [Am J Hematol] 2021 Apr 01; Vol. 96 (4), pp. E95-E98. Date of Electronic Publication: 2021 Jan 11.
Typ publikacji :
Clinical Trial; Letter; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Leukemia, Lymphocytic, Chronic, B-Cell/*drug therapy
Neoplasm Proteins/*antagonists & inhibitors
Pyrimethamine/*therapeutic use
STAT3 Transcription Factor/*antagonists & inhibitors
Adult ; Aged ; Aged, 80 and over ; Antineoplastic Agents/administration & dosage ; B-Lymphocytes/drug effects ; B-Lymphocytes/metabolism ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Drug Repositioning ; Drug Screening Assays, Antitumor ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Leukemic/drug effects ; Humans ; Male ; Middle Aged ; Neoplasm Proteins/biosynthesis ; Neoplasm Proteins/genetics ; Progression-Free Survival ; Pyrimethamine/administration & dosage ; Pyrimethamine/pharmacology
Raport
Tytuł :
Glucose-regulated protein (GRP78) is an important cell surface receptor for viral invasion, cancers, and neurological disorders.
Autorzy :
Gonzalez-Gronow M; Department of Biological Sciences, Laboratory of Environmental Neurotoxicology, Faculty of Medicine, Universidad Católica del Norte, Coquimbo, Chile.; Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA.
Gopal U; Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA.
Austin RC; Department of Medicine, Division of Nephrology, McMaster University and The Research Institute of St. Joseph's Hamilton, Hamilton, Ontario, Canada.
Pizzo SV; Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA.
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Źródło :
IUBMB life [IUBMB Life] 2021 Jun; Vol. 73 (6), pp. 843-854. Date of Electronic Publication: 2021 May 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Autoimmune Diseases of the Nervous System/*immunology
COVID-19/*transmission
Heat-Shock Proteins/*physiology
Neoplasm Proteins/*physiology
Nerve Tissue Proteins/*physiology
Receptors, Cell Surface/*physiology
Receptors, Virus/*physiology
SARS-CoV-2/*metabolism
Spike Glycoprotein, Coronavirus/*metabolism
Autoantibodies/immunology ; Autoantigens/immunology ; Autoimmune Diseases of the Nervous System/metabolism ; Cell Survival ; Endoplasmic Reticulum Stress/physiology ; Exosomes ; GPI-Linked Proteins/metabolism ; Heat-Shock Proteins/chemistry ; Heat-Shock Proteins/immunology ; Humans ; Ligands ; Neoplasm Invasiveness ; Neoplasm Proteins/immunology ; Nerve Tissue Proteins/immunology ; Protein Domains ; Protein Transport ; Signal Transduction ; Tumor Microenvironment ; Unfolded Protein Response/physiology ; Virus Internalization
Czasopismo naukowe
Tytuł :
The silencing of FNDC1 inhibits the tumorigenesis of breast cancer cells via modulation of the PI3K/Akt signaling pathway.
Autorzy :
Yunwen C; Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang 315010, P.R. China.
Shanshan G; Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang 315010, P.R. China.
Zhifei B; Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang 315010, P.R. China.
Saijun C; Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang 315010, P.R. China.
Hua Y; Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang 315010, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2021 Jun; Vol. 23 (6). Date of Electronic Publication: 2021 Apr 26.
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*
Breast Neoplasms/*genetics
Carcinogenesis/*genetics
Neoplasm Proteins/*metabolism
Phosphatidylinositol 3-Kinases/*metabolism
Breast Neoplasms/metabolism ; Cell Line ; Cell Movement ; Cell Survival ; Female ; Humans ; MCF-7 Cells ; Matrix Metalloproteinases/metabolism ; Neoplasm Proteins/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Up-Regulation
Czasopismo naukowe
Tytuł :
In vitro evaluation of intestinal absorption of tiliroside from Edgeworthia gardneri (Wall.) Meisn.
Autorzy :
Yin X; School of Pharmaceutical Sciences, Chongqing University, Chongqing, China.
Wang M; School of Pharmaceutical Sciences, Chongqing University, Chongqing, China.
Xia Z; School of Pharmaceutical Sciences, Chongqing University, Chongqing, China.
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Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Jun; Vol. 51 (6), pp. 728-736. Date of Electronic Publication: 2021 Apr 20.
Typ publikacji :
Journal Article
MeSH Terms :
Neoplasm Proteins*/metabolism
Thymelaeaceae*/metabolism
ATP Binding Cassette Transporter, Subfamily G, Member 2 ; Flavonoids ; Intestinal Absorption ; Multidrug Resistance-Associated Proteins/metabolism
Czasopismo naukowe
Tytuł :
Nuclear overexpression levels of MAGE-A3 predict poor prognosis in patients with prostate cancer.
Autorzy :
Khalvandi A; Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Abolhasani M; Hasheminejad Kidney Center, Iran University of Medical Sciences, Tehran, Iran.; Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Madjd Z; Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Shekarabi M; Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Kourosh-Arami M; Department of Neuroscience, School of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.
Mohsenzadegan M; Department of Medical Laboratory Science, Faculty of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran.
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Źródło :
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica [APMIS] 2021 Jun; Vol. 129 (6), pp. 291-303. Date of Electronic Publication: 2021 Apr 13.
Typ publikacji :
Journal Article
MeSH Terms :
Antigens, Neoplasm/*biosynthesis
Biomarkers, Tumor/*metabolism
Neoplasm Proteins/*biosynthesis
Prostatic Neoplasms/*pathology
Aged ; Aged, 80 and over ; Antigens, Neoplasm/analysis ; Biomarkers, Tumor/analysis ; Cell Nucleus/metabolism ; Humans ; Male ; Middle Aged ; Neoplasm Proteins/analysis ; Prognosis ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/mortality ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Androgen signaling uses a writer and a reader of ADP-ribosylation to regulate protein complex assembly.
Autorzy :
Yang CS; Center for Cell Signaling, University of Virginia, Charlottesville, VA, USA.; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA.
Jividen K; Center for Cell Signaling, University of Virginia, Charlottesville, VA, USA.
Kamata T; Center for Cell Signaling, University of Virginia, Charlottesville, VA, USA.; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA.
Dworak N; Center for Cell Signaling, University of Virginia, Charlottesville, VA, USA.
Oostdyk L; Center for Cell Signaling, University of Virginia, Charlottesville, VA, USA.; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA.
Remlein B; Center for Cell Signaling, University of Virginia, Charlottesville, VA, USA.; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA.
Pourfarjam Y; Department of Chemistry, University of Cincinnati, Cincinnati, OH, USA.
Kim IK; Department of Chemistry, University of Cincinnati, Cincinnati, OH, USA.
Du KP; Department of Radiation Oncology, University of Virginia, Charlottesville, VA, USA.
Abbas T; Center for Cell Signaling, University of Virginia, Charlottesville, VA, USA.; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA.; Department of Radiation Oncology, University of Virginia, Charlottesville, VA, USA.
Sherman NE; W. M. Keck Biomedical Mass Spectrometry Laboratory, University of Virginia, Charlottesville, VA, USA.
Wotton D; Center for Cell Signaling, University of Virginia, Charlottesville, VA, USA.; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA.
Paschal BM; Center for Cell Signaling, University of Virginia, Charlottesville, VA, USA. .; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 May 11; Vol. 12 (1), pp. 2705. Date of Electronic Publication: 2021 May 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Protein Processing, Post-Translational*
Neoplasm Proteins/*genetics
Poly(ADP-ribose) Polymerases/*genetics
Prostatic Neoplasms/*genetics
Receptors, Androgen/*genetics
ADP-Ribosylation/drug effects ; Adenocarcinoma ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Humans ; Male ; Metribolone/pharmacology ; Neoplasm Proteins/metabolism ; Phthalazines/pharmacology ; Piperazines/pharmacology ; Poly (ADP-Ribose) Polymerase-1/genetics ; Poly (ADP-Ribose) Polymerase-1/metabolism ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Poly(ADP-ribose) Polymerases/metabolism ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Receptors, Androgen/metabolism ; Signal Transduction ; Survival Analysis
Czasopismo naukowe
Tytuł :
Integration of machine learning and genome-scale metabolic modeling identifies multi-omics biomarkers for radiation resistance.
Autorzy :
Lewis JE; The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Kemp ML; The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 May 11; Vol. 12 (1), pp. 2700. Date of Electronic Publication: 2021 May 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Genome, Human*
Machine Learning*
Neoplasm Proteins/*genetics
Neoplasms/*radiotherapy
Radiation Tolerance/*genetics
Atlases as Topic ; Cell Line, Tumor ; Databases, Genetic ; Datasets as Topic ; Gene Expression Regulation, Neoplastic ; Humans ; Metabolic Networks and Pathways ; Neoplasm Proteins/metabolism ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/mortality ; Radiation, Ionizing ; Survival Analysis ; Transcriptome ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Immune evolution from preneoplasia to invasive lung adenocarcinomas and underlying molecular features.
Autorzy :
Dejima H; Department of Translational Molecular Pathology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Hu X; Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Chen R; Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Zhang J; Department of Bioinformatics & Computational Biology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Fujimoto J; Department of Translational Molecular Pathology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Parra ER; Department of Translational Molecular Pathology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Haymaker C; Department of Translational Molecular Pathology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Hubert SM; Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Duose D; Department of Translational Molecular Pathology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Solis LM; Department of Translational Molecular Pathology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Su D; Institute of Cancer and Basic Medicine (IBMC), Chinese Academy of Sciences, Hangzhou, China.; Department of Pathology, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, China.
Fukuoka J; Department of Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Tabata K; Department of Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Pham HHN; Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Mcgranahan N; Cancer Research United Kingdom-University College London Lung Cancer Centre of Excellence, London, UK.
Zhang B; Department of Translational Molecular Pathology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Ye J; Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Ying L; Institute of Cancer and Basic Medicine (IBMC), Chinese Academy of Sciences, Hangzhou, China.; Zhejiang Cancer Research Institute, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, China.
Little L; Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Gumbs C; Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Chow CW; Department of Translational Molecular Pathology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Estecio MR; Department of Epigenetics and Molecular Carcinogenesis, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Center of Cancer Epigenetics, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Godoy MCB; Department of Thoracic Imaging, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Antonoff MB; Department of Thoracic and Cardiovascular Surgery, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Sepesi B; Department of Thoracic and Cardiovascular Surgery, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Pass HI; Department of Cardiothoracic Surgery, New York University Langone Medical Center, New York, NY, USA.
Behrens C; Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Zhang J; Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Vaporciyan AA; Department of Thoracic and Cardiovascular Surgery, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Heymach JV; Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Scheet P; Department of Epidemiology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Lee JJ; Department of Biostatistics, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Wu J; Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Futreal PA; Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Reuben A; Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA. .
Kadara H; Department of Translational Molecular Pathology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA. .
Wistuba II; Department of Translational Molecular Pathology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA. .
Zhang J; Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX, USA. .; Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 May 11; Vol. 12 (1), pp. 2722. Date of Electronic Publication: 2021 May 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Transcriptome*
Adenocarcinoma in Situ/*genetics
Adenocarcinoma of Lung/*genetics
Carcinogenesis/*genetics
Lung Neoplasms/*genetics
Neoplasm Proteins/*genetics
Precancerous Conditions/*genetics
Adenocarcinoma in Situ/immunology ; Adenocarcinoma in Situ/pathology ; Adenocarcinoma of Lung/immunology ; Adenocarcinoma of Lung/pathology ; Carcinogenesis/immunology ; Carcinogenesis/pathology ; Chromosome Aberrations ; Clone Cells ; DNA Copy Number Variations ; DNA Methylation ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Immunity, Innate ; Lung/immunology ; Lung/metabolism ; Lung/pathology ; Lung Neoplasms/immunology ; Lung Neoplasms/pathology ; Neoplasm Proteins/immunology ; Precancerous Conditions/immunology ; Precancerous Conditions/pathology ; Signal Transduction ; T-Lymphocytes, Cytotoxic/immunology ; T-Lymphocytes, Cytotoxic/pathology ; T-Lymphocytes, Helper-Inducer/immunology ; T-Lymphocytes, Helper-Inducer/pathology ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/pathology ; Tumor Escape/genetics ; Tumor Escape/immunology ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology
Czasopismo naukowe
Tytuł :
iPSC modeling of stage-specific leukemogenesis reveals BAALC as a key oncogene in severe congenital neutropenia.
Autorzy :
Dannenmann B; Department of Oncology, Hematology, Immunology, and Rheumatology, University Hospital Tuebingen, 72074 Tuebingen, Germany.
Klimiankou M; Department of Oncology, Hematology, Immunology, and Rheumatology, University Hospital Tuebingen, 72074 Tuebingen, Germany.
Oswald B; Department of Oncology, Hematology, Immunology, and Rheumatology, University Hospital Tuebingen, 72074 Tuebingen, Germany.
Solovyeva A; Department of Oncology, Hematology, Immunology, and Rheumatology, University Hospital Tuebingen, 72074 Tuebingen, Germany.
Mardan J; Department of Oncology, Hematology, Immunology, and Rheumatology, University Hospital Tuebingen, 72074 Tuebingen, Germany.
Nasri M; Department of Oncology, Hematology, Immunology, and Rheumatology, University Hospital Tuebingen, 72074 Tuebingen, Germany.
Ritter M; Department of Oncology, Hematology, Immunology, and Rheumatology, University Hospital Tuebingen, 72074 Tuebingen, Germany.
Zahabi A; Department of Oncology, Hematology, Immunology, and Rheumatology, University Hospital Tuebingen, 72074 Tuebingen, Germany.
Arreba-Tutusaus P; Department of Oncology, Hematology, Immunology, and Rheumatology, University Hospital Tuebingen, 72074 Tuebingen, Germany.
Mir P; Department of Oncology, Hematology, Immunology, and Rheumatology, University Hospital Tuebingen, 72074 Tuebingen, Germany.
Stein F; Department of Oncology, Hematology, Immunology, and Rheumatology, University Hospital Tuebingen, 72074 Tuebingen, Germany.
Kandabarau S; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology (IKP), 70376 Stuttgart, Germany.
Lachmann N; Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.
Moritz T; Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.
Morishima T; Department of Oncology, Hematology, Immunology, and Rheumatology, University Hospital Tuebingen, 72074 Tuebingen, Germany.
Konantz M; Department of Biomedicine, University Hospital Basel, 4031 Basel, Switzerland.
Lengerke C; Department of Oncology, Hematology, Immunology, and Rheumatology, University Hospital Tuebingen, 72074 Tuebingen, Germany; Department of Biomedicine, University Hospital Basel, 4031 Basel, Switzerland.
Ripperger T; Institute of Human Genetics, Hannover Medical School, 30625 Hannover, Germany.
Steinemann D; Institute of Human Genetics, Hannover Medical School, 30625 Hannover, Germany.
Erlacher M; Faculty of Medicine, Division of Pediatric Hematology and Oncology Medical Center, Department of Pediatrics and Adolescent Medicine, University of Freiburg, 79106 Freiburg, Germany; German Cancer Consortium (DKTK), 79106 Freiburg, Germany; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Niemeyer CM; Faculty of Medicine, Division of Pediatric Hematology and Oncology Medical Center, Department of Pediatrics and Adolescent Medicine, University of Freiburg, 79106 Freiburg, Germany; German Cancer Consortium (DKTK), 79106 Freiburg, Germany; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Zeidler C; Department of Oncology, Hematology, Immunology and Bone Marrow Transplantation, Hannover Medical School, 39625 Hannover, Germany.
Welte K; University Children's Hospital Tuebingen, 72074 Tuebingen, Germany.
Skokowa J; Department of Oncology, Hematology, Immunology, and Rheumatology, University Hospital Tuebingen, 72074 Tuebingen, Germany. Electronic address: .
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Źródło :
Cell stem cell [Cell Stem Cell] 2021 May 06; Vol. 28 (5), pp. 906-922.e6. Date of Electronic Publication: 2021 Apr 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Induced Pluripotent Stem Cells*
Leukemia, Myeloid, Acute*/genetics
Neoplasm Proteins*/genetics
Neutropenia*/congenital
Neutropenia*/genetics
Congenital Bone Marrow Failure Syndromes ; Humans ; Mutation/genetics ; Oncogenes
SCR Disease Name :
Neutropenia, Severe Congenital, Autosomal Recessive 3
Czasopismo naukowe
Tytuł :
Systematic insight into the active constituents and mechanism of Guiqi Baizhu for the treatment of gastric cancer.
Autorzy :
Li L; Gansu University Key Laboratory for Molecular Medicine & Chinese Medicine Prevention and Treatment of Major Diseases, Gansu University of Chinese Medicine, Lanzhou, China.
Jin XJ; Gansu University Key Laboratory for Molecular Medicine & Chinese Medicine Prevention and Treatment of Major Diseases, Gansu University of Chinese Medicine, Lanzhou, China.; College of Pharmacy, Gansu University of Chinese Medicine, Lanzhou, China.
Li JW; Gansu University Key Laboratory for Molecular Medicine & Chinese Medicine Prevention and Treatment of Major Diseases, Gansu University of Chinese Medicine, Lanzhou, China.; School of basic medical sciences, Gansu University of Chinese Medicine, Lanzhou, China.
Li CH; Gansu University Key Laboratory for Molecular Medicine & Chinese Medicine Prevention and Treatment of Major Diseases, Gansu University of Chinese Medicine, Lanzhou, China.
Zhou SY; Chongqing Key Laboratory of Big Data for Bio Intelligence, Chongqing University of Posts and Telecommunications, Chongqing, China.
Li JJ; Gansu University Key Laboratory for Molecular Medicine & Chinese Medicine Prevention and Treatment of Major Diseases, Gansu University of Chinese Medicine, Lanzhou, China.
Feng CQ; Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou, China.
Liu DL; Gansu University Key Laboratory for Molecular Medicine & Chinese Medicine Prevention and Treatment of Major Diseases, Gansu University of Chinese Medicine, Lanzhou, China.; College of Pharmacy, Gansu University of Chinese Medicine, Lanzhou, China.
Liu YQ; Gansu University Key Laboratory for Molecular Medicine & Chinese Medicine Prevention and Treatment of Major Diseases, Gansu University of Chinese Medicine, Lanzhou, China.; Key Laboratory of Dun huang Medical and Transformation, Ministry of Education of The People's Republic of China, Gansu University of Chinese Medicine, Lanzhou, China.
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Źródło :
Cancer science [Cancer Sci] 2021 May; Vol. 112 (5), pp. 1772-1784. Date of Electronic Publication: 2021 Mar 07.
Typ publikacji :
Journal Article
MeSH Terms :
B7-H1 Antigen/*metabolism
Drugs, Chinese Herbal/*metabolism
Neoplasm Proteins/*metabolism
Receptor, ErbB-2/*metabolism
Stomach Neoplasms/*metabolism
B7-H1 Antigen/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Isoflavones/metabolism ; Isoflavones/pharmacology ; Molecular Docking Simulation/methods ; Neoplasm Proteins/chemistry ; Phosphatidylinositol 3-Kinases/metabolism ; Protein Structure, Quaternary ; Protein Structure, Tertiary ; Proto-Oncogene Proteins c-akt/metabolism ; Quercetin/analogs & derivatives ; Quercetin/metabolism ; Quercetin/pharmacology ; Receptor, ErbB-2/antagonists & inhibitors ; Receptor, ErbB-2/chemistry ; Signal Transduction ; Stomach Neoplasms/drug therapy
Czasopismo naukowe
Tytuł :
RPL34-AS1-induced RPL34 inhibits cervical cancer cell tumorigenesis via the MDM2-P53 pathway.
Autorzy :
Zhu Y; Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, P.R. China.
Ren C; Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, P.R. China.
Jiang D; Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, P.R. China.
Yang L; Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, P.R. China.
Chen Y; Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, P.R. China.
Li F; Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, P.R. China.
Wang B; Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, P.R. China.
Zhang Y; Department of pathology, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou, P.R. China.
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Źródło :
Cancer science [Cancer Sci] 2021 May; Vol. 112 (5), pp. 1811-1821. Date of Electronic Publication: 2021 Mar 18.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma in Situ/*etiology
Neoplasm Proteins/*metabolism
Proto-Oncogene Proteins c-mdm2/*metabolism
Ribosomal Proteins/*metabolism
Tumor Suppressor Protein p53/*metabolism
Uterine Cervical Neoplasms/*etiology
Adult ; Animals ; Carcinoma in Situ/metabolism ; Carcinoma in Situ/pathology ; Carcinoma in Situ/prevention & control ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; DEAD-box RNA Helicases/metabolism ; Down-Regulation ; Eukaryotic Initiation Factor-4A/metabolism ; Female ; HeLa Cells ; Humans ; Immunoprecipitation/methods ; Mice ; Mice, Nude ; Neoplasm Invasiveness ; Neoplasm Proteins/analysis ; Proto-Oncogene Proteins c-mdm2/antagonists & inhibitors ; RNA, Long Noncoding/metabolism ; Uterine Cervical Neoplasms/metabolism ; Uterine Cervical Neoplasms/pathology ; Uterine Cervical Neoplasms/prevention & control
Czasopismo naukowe
Tytuł :
MicroRNA‑199a/b‑5p inhibits endometrial cancer cell metastasis and invasion by targeting FAM83B in the epithelial‑to‑mesenchymal transition signaling pathway.
Autorzy :
Xiong H; Department of Pathology, Central Laboratory of The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, P.R. China.
Wang N; Department of Pathology, Central Laboratory of The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, P.R. China.
Chen H; Department of Pathology, Central Laboratory of The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, P.R. China.
Zhang M; Department of Pathology, Central Laboratory of The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, P.R. China.
Lin Q; Department of Gynecology and Obstetrics, Guangzhou Institute of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2021 May; Vol. 23 (5). Date of Electronic Publication: 2021 Mar 02.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Endometrial Neoplasms/*genetics
Epithelial-Mesenchymal Transition/*genetics
MicroRNAs/*genetics
Neoplasm Proteins/*genetics
Signal Transduction/*genetics
3' Untranslated Regions/genetics ; Animals ; Cell Line ; Cell Line, Tumor ; Cell Movement/genetics ; Endometrial Neoplasms/metabolism ; Endometrial Neoplasms/pathology ; Female ; Gene Expression Profiling/methods ; Humans ; Mice, Inbred BALB C ; Mice, Nude ; Neoplasm Invasiveness ; Neoplasm Metastasis ; Neoplasm Proteins/metabolism ; Transplantation, Heterologous
Czasopismo naukowe
Tytuł :
Hexokinase 2 in Cancer: A Prima Donna Playing Multiple Characters.
Autorzy :
Ciscato F; Dipartimento di Scienze Biomediche, Università di Padova, 35131 Padova, Italy.
Ferrone L; Dipartimento di Scienze Biomediche, Università di Padova, 35131 Padova, Italy.
Masgras I; Dipartimento di Scienze Biomediche, Università di Padova, 35131 Padova, Italy.; Institute of Neuroscience, National Research Council, 56124 Pias, Italy.
Laquatra C; Dipartimento di Scienze Biomediche, Università di Padova, 35131 Padova, Italy.
Rasola A; Dipartimento di Scienze Biomediche, Università di Padova, 35131 Padova, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 29; Vol. 22 (9). Date of Electronic Publication: 2021 Apr 29.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Hexokinase/*physiology
Neoplasm Proteins/*physiology
Neoplasms/*enzymology
Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Apoptosis/physiology ; Autophagy/physiology ; Calcium Signaling/physiology ; Cell Hypoxia ; Cell-Penetrating Peptides/therapeutic use ; Enzyme Induction ; Gene Expression Regulation, Neoplastic ; Glycolysis/physiology ; Hexokinase/antagonists & inhibitors ; Humans ; Intracellular Membranes/enzymology ; Mice ; MicroRNAs/genetics ; Mitochondria/metabolism ; Molecular Targeted Therapy ; Neoplasm Proteins/antagonists & inhibitors ; Neoplasms/therapy ; Neoplasms, Experimental/enzymology ; Phosphorylation ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Protein Processing, Post-Translational ; Rats ; Ubiquitination
Czasopismo naukowe

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