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Tytuł :
The adaptive immune system is a major driver of selection for tumor suppressor gene inactivation.
Autorzy :
Martin TD; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Patel RS; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Cook DR; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Choi MY; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Patil A; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Liang AC; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Li MZ; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Haigis KM; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Elledge SJ; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Sep 17; Vol. 373 (6561), pp. 1327-1335. Date of Electronic Publication: 2021 Sep 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinogenesis*
Gene Silencing*
Genes, Tumor Suppressor*
Immune Evasion*/genetics
Neoplasms, Experimental/*genetics
Neoplasms, Experimental/*immunology
Animals ; CRISPR-Cas Systems ; Cell Line, Tumor ; Chemokine CCL2/metabolism ; Female ; GTP-Binding Protein alpha Subunits, G12-G13/genetics ; GTP-Binding Protein alpha Subunits, G12-G13/metabolism ; Humans ; Mammary Neoplasms, Experimental/genetics ; Mammary Neoplasms, Experimental/immunology ; Mammary Neoplasms, Experimental/pathology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, SCID ; Neoplasm Transplantation ; Neoplasms, Experimental/pathology ; Selection, Genetic ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis.
Autorzy :
Samuel M; Department of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Bundoora, VIC, Australia.
Fonseka P; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Sanwlani R; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Gangoda L; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Chee SH; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Keerthikumar S; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia.
Spurling A; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Chitti SV; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Zanker D; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Ang CS; Bio21 Institute, University of Melbourne, Melbourne, VIC, Australia.
Atukorala I; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Kang T; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Shahi S; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Marzan AL; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Nedeva C; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Vennin C; Garvan Institute of Medical Research, The Kinghorn Cancer Centre & St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
Lucas MC; Garvan Institute of Medical Research, The Kinghorn Cancer Centre & St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
Cheng L; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Herrmann D; Garvan Institute of Medical Research, The Kinghorn Cancer Centre & St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
Pathan M; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Chisanga D; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Warren SC; Garvan Institute of Medical Research, The Kinghorn Cancer Centre & St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
Zhao K; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Abraham N; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Anand S; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Boukouris S; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Adda CG; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Jiang L; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Shekhar TM; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Baschuk N; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Hawkins CJ; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Johnston AJ; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Orian JM; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Hoogenraad NJ; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Poon IK; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Hill AF; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Jois M; Department of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Bundoora, VIC, Australia.
Timpson P; Garvan Institute of Medical Research, The Kinghorn Cancer Centre & St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
Parker BS; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Mathivanan S; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia. .
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Źródło :
Nature communications [Nat Commun] 2021 Jun 24; Vol. 12 (1), pp. 3950. Date of Electronic Publication: 2021 Jun 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Extracellular Vesicles*/chemistry
Extracellular Vesicles*/genetics
Milk/*cytology
Neoplasms, Experimental/*pathology
Administration, Oral ; Animals ; Biological Availability ; Breast Neoplasms/pathology ; Breast Neoplasms/therapy ; Cattle ; Cell Line, Tumor ; Cell Proliferation ; Epithelial-Mesenchymal Transition ; Female ; Humans ; Liver Neoplasms, Experimental/pathology ; Liver Neoplasms, Experimental/secondary ; Lung Neoplasms/pathology ; Lung Neoplasms/secondary ; Mice, Inbred BALB C ; Neoplasms, Experimental/therapy ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/therapy ; Tissue Distribution ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Effect of immune modulation on the skeletal muscle mitochondrial exercise response: An exploratory study in mice with cancer.
Autorzy :
Buss LA; Mackenzie Cancer Research Group, Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand.
Hock B; Hematology Research Group, Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand.
Merry TL; Discipline of Nutrition, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand.
Ang AD; Mackenzie Cancer Research Group, Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand.
Robinson BA; Mackenzie Cancer Research Group, Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand.; Canterbury Regional Cancer and Hematology Service, Canterbury District Health Board, Christchurch, New Zealand.
Currie MJ; Mackenzie Cancer Research Group, Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand.
Dachs GU; Mackenzie Cancer Research Group, Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand.
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Źródło :
PloS one [PLoS One] 2021 Oct 19; Vol. 16 (10), pp. e0258831. Date of Electronic Publication: 2021 Oct 19 (Print Publication: 2021).
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immune Checkpoint Inhibitors/*administration & dosage
Immunoglobulin G/*administration & dosage
Mammary Neoplasms, Experimental/*therapy
Melanoma, Experimental/*therapy
Mitochondria, Muscle/*metabolism
Muscle, Skeletal/*metabolism
Physical Conditioning, Animal/*methods
Animals ; Cell Line, Tumor ; Citrate (si)-Synthase/metabolism ; Electron Transport Complex IV/metabolism ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Immune Checkpoint Inhibitors/pharmacology ; Immunoglobulin G/pharmacology ; Immunotherapy ; Mammary Neoplasms, Experimental/immunology ; Mammary Neoplasms, Experimental/metabolism ; Melanoma, Experimental/immunology ; Melanoma, Experimental/metabolism ; Mice ; Muscle, Skeletal/drug effects ; Random Allocation ; Treatment Outcome
Czasopismo naukowe
Tytuł :
c-Myc-driven Hepatocarcinogenesis.
Autorzy :
Moon H; Department of Genetics and Biotechnology, College of Life Sciences, Kyung Hee University, Gyeonggi-do, Republic of Korea.
Park H; Department of Genetics and Biotechnology, College of Life Sciences, Kyung Hee University, Gyeonggi-do, Republic of Korea.; Graduate School of Biotechnology, College of Life Sciences, Kyung Hee University, Gyeonggi-do, Republic of Korea.
Ro SW; Department of Genetics and Biotechnology, College of Life Sciences, Kyung Hee University, Gyeonggi-do, Republic of Korea; .; Graduate School of Biotechnology, College of Life Sciences, Kyung Hee University, Gyeonggi-do, Republic of Korea.
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Źródło :
Anticancer research [Anticancer Res] 2021 Oct; Vol. 41 (10), pp. 4937-4946.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinogenesis/*pathology
Carcinoma, Hepatocellular/*pathology
Liver Neoplasms/*pathology
Liver Neoplasms, Experimental/*pathology
Proto-Oncogene Proteins c-myc/*metabolism
Tumor Suppressor Protein p53/*metabolism
Animals ; Apoptosis ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Cell Proliferation ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Liver Neoplasms, Experimental/genetics ; Liver Neoplasms, Experimental/metabolism ; Mice ; Mice, Inbred C57BL ; Proto-Oncogene Proteins c-myc/genetics ; Tumor Cells, Cultured ; Tumor Suppressor Protein p53/genetics
Czasopismo naukowe
Tytuł :
Farnesol alleviates diethyl nitrosamine induced inflammation and protects experimental rat hepatocellular carcinoma.
Autorzy :
Balaraman G; Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India.
Sundaram J; Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India.
Mari A; Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India.
Krishnan P; Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India.
Salam S; Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India.
Subramaniam N; Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India.
Sirajduddin I; Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India.
Thiruvengadam D; Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India.
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Źródło :
Environmental toxicology [Environ Toxicol] 2021 Dec; Vol. 36 (12), pp. 2467-2474. Date of Electronic Publication: 2021 Sep 02.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Hepatocellular*/chemically induced
Carcinoma, Hepatocellular*/metabolism
Carcinoma, Hepatocellular*/prevention & control
Liver Neoplasms*/chemically induced
Liver Neoplasms*/metabolism
Liver Neoplasms*/prevention & control
Liver Neoplasms, Experimental*/metabolism
Animals ; Antioxidants/metabolism ; Diethylnitrosamine/toxicity ; Farnesol/pharmacology ; Inflammation/chemically induced ; Inflammation/metabolism ; Inflammation/prevention & control ; Liver/metabolism ; Male ; Oxidative Stress ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Regulatory T Cells Shape the Differential Impact of Radiation Dose-Fractionation Schedules on Host Innate and Adaptive Antitumor Immune Defenses.
Autorzy :
Sia J; Translational Hematology Program, Peter MacCallum Cancer Centre, Melbourne, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Australia; Radiation Oncology Department, Peter MacCallum Cancer Centre, Melbourne, Australia.
Hagekyriakou J; Physical Sciences Department, Peter MacCallum Cancer Centre, Melbourne, Australia.
Chindris I; Translational Hematology Program, Peter MacCallum Cancer Centre, Melbourne, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Australia.
Albarakati H; Physical Sciences Department, Peter MacCallum Cancer Centre, Melbourne, Australia.
Leong T; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Australia; Radiation Oncology Department, Peter MacCallum Cancer Centre, Melbourne, Australia.
Schlenker R; Roche Pharmaceutical Research and Early Development, Roche Innovation Centre Munich, Penzberg, Germany.
Keam SP; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Australia; Tumour Suppression Laboratory, Peter MacCallum Cancer Centre, Melbourne, Australia; Cancer Immunology Research Program, Peter MacCallum Cancer Centre, Melbourne, Australia.
Williams SG; Radiation Oncology Department, Peter MacCallum Cancer Centre, Melbourne, Australia.
Neeson PJ; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Australia; Cancer Immunology Research Program, Peter MacCallum Cancer Centre, Melbourne, Australia.
Johnstone RW; Translational Hematology Program, Peter MacCallum Cancer Centre, Melbourne, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Australia.
Haynes NM; Translational Hematology Program, Peter MacCallum Cancer Centre, Melbourne, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Australia. Electronic address: .
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Źródło :
International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 2021 Oct 01; Vol. 111 (2), pp. 502-514. Date of Electronic Publication: 2021 May 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dose Fractionation, Radiation*
Neoplasms, Experimental/*radiotherapy
T-Lymphocytes, Regulatory/*immunology
Adaptive Immunity/radiation effects ; Animals ; CD8-Positive T-Lymphocytes/immunology ; Female ; Immunity, Innate/radiation effects ; Immunomodulation ; Killer Cells, Natural/immunology ; Mice ; Mice, Inbred C57BL ; Neoplasms, Experimental/immunology
Czasopismo naukowe
Tytuł :
Environmental eustress modulates β-ARs/CCL2 axis to induce anti-tumor immunity and sensitize immunotherapy against liver cancer in mice.
Autorzy :
Liu C; State Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.; School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Yang Y; State Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Chen C; State Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Li L; State Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Li J; State Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Wang X; State Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Chu Q; State Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Qiu L; CAS Key Laboratory of Nutrition, Metabolism and Food safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Ba Q; State Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Li X; State Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. .
Wang H; State Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. .; CAS Key Laboratory of Nutrition, Metabolism and Food safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China. .
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Źródło :
Nature communications [Nat Commun] 2021 Sep 30; Vol. 12 (1), pp. 5725. Date of Electronic Publication: 2021 Sep 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Neuroimmunomodulation*
Drug Resistance, Neoplasm/*immunology
Immune Checkpoint Inhibitors/*pharmacology
Liver Neoplasms, Experimental/*drug therapy
Stress, Psychological/*immunology
Animals ; B7-H1 Antigen/antagonists & inhibitors ; Carbon Tetrachloride/administration & dosage ; Carbon Tetrachloride/toxicity ; Chemokine CCL2/antagonists & inhibitors ; Chemokine CCL2/metabolism ; Diethylnitrosamine/administration & dosage ; Diethylnitrosamine/toxicity ; Hepatic Stellate Cells ; Hepatocytes ; Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Liver/drug effects ; Liver/immunology ; Liver/pathology ; Liver Neoplasms, Experimental/chemically induced ; Liver Neoplasms, Experimental/immunology ; Liver Neoplasms, Experimental/pathology ; Male ; Mice ; Organoids ; Receptors, Adrenergic, beta/metabolism ; Receptors, CCR2/antagonists & inhibitors ; Receptors, CCR2/metabolism ; Signal Transduction/drug effects ; Signal Transduction/immunology ; Sympathetic Nervous System/immunology ; Tumor Escape ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/immunology
Czasopismo naukowe
Tytuł :
Abscopal Effect of Radiotherapy Enhanced with Immune Checkpoint Inhibitors of Triple Negative Breast Cancer in 4T1 Mammary Carcinoma Model.
Autorzy :
Song HN; Division of Hemato-Oncology, Department of Internal Medicine, Gyeongsang National University of Medicine and Gyeongsang National University Hospital, Jinju 52727, Korea.; Institute of Health Science, Gyeongsang National University, Jinju 52727, Korea.; Biomedical Research Institute, Gyeongsang National University Hospital, Jinju 52727, Korea.
Jin H; Institute of Health Science, Gyeongsang National University, Jinju 52727, Korea.; Department of Pharmacology, School of Medicine, Gyeongsang National University, Jinju 52727, Korea.
Kim JH; Division of Hemato-Oncology, Department of Internal Medicine, Gyeongsang National University of Medicine and Gyeongsang National University Hospital, Jinju 52727, Korea.; Institute of Health Science, Gyeongsang National University, Jinju 52727, Korea.; Biomedical Research Institute, Gyeongsang National University Hospital, Jinju 52727, Korea.
Ha IB; Institute of Health Science, Gyeongsang National University, Jinju 52727, Korea.; Biomedical Research Institute, Gyeongsang National University Hospital, Jinju 52727, Korea.; Department of Radiation Oncology, Gyeongsang National University of Medicine and Gyeongsang National University Hospital, Jinju 52727, Korea.
Kang KM; Institute of Health Science, Gyeongsang National University, Jinju 52727, Korea.; Biomedical Research Institute, Gyeongsang National University Hospital, Jinju 52727, Korea.; Department of Radiation Oncology, Gyeongsang National University Changwon Hospital, Gyeongsang National University College of Medicine, Changwon 51472, Korea.
Choi HS; Institute of Health Science, Gyeongsang National University, Jinju 52727, Korea.; Biomedical Research Institute, Gyeongsang National University Hospital, Jinju 52727, Korea.; Department of Radiation Oncology, Gyeongsang National University Changwon Hospital, Gyeongsang National University College of Medicine, Changwon 51472, Korea.
Jeong HJ; Institute of Health Science, Gyeongsang National University, Jinju 52727, Korea.; Biomedical Research Institute, Gyeongsang National University Hospital, Jinju 52727, Korea.; Department of Radiation Oncology, Gyeongsang National University of Medicine and Gyeongsang National University Hospital, Jinju 52727, Korea.
Kim MY; Division of Endocrinology, Department of Internal Medicine, Gyeongsang National University of Medicine and Gyeongsang National University Hospital, Jinju 52727, Korea.
Kim HJ; Institute of Health Science, Gyeongsang National University, Jinju 52727, Korea.; Department of Pharmacology, School of Medicine, Gyeongsang National University, Jinju 52727, Korea.
Jeong BK; Institute of Health Science, Gyeongsang National University, Jinju 52727, Korea.; Biomedical Research Institute, Gyeongsang National University Hospital, Jinju 52727, Korea.; Department of Radiation Oncology, Gyeongsang National University of Medicine and Gyeongsang National University Hospital, Jinju 52727, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 28; Vol. 22 (19). Date of Electronic Publication: 2021 Sep 28.
Typ publikacji :
Journal Article
MeSH Terms :
Immune Checkpoint Inhibitors/*pharmacology
Lung Neoplasms/*prevention & control
Mammary Neoplasms, Experimental/*therapy
Radiation Tolerance/*drug effects
Animals ; Cell Line, Tumor ; Female ; Lung Neoplasms/immunology ; Lung Neoplasms/pathology ; Lung Neoplasms/secondary ; Mammary Neoplasms, Experimental/immunology ; Mammary Neoplasms, Experimental/pathology ; Mice ; Mice, Inbred BALB C ; Neoplasm Metastasis ; Radiation Tolerance/immunology ; Radiation Tolerance/radiation effects
Czasopismo naukowe
Tytuł :
Human CD22-Transgenic, Primary Murine Lymphoma Challenges Immunotherapies in Organ-Specific Tumor Microenvironments.
Autorzy :
Gsottberger F; Department of Internal Medicine 5, Haematology and Oncology, University Hospital of Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg (FAU), 91054 Erlangen, Germany.
Brandl C; Department of Biology, Friedrich-Alexander University of Erlangen-Nuremberg (FAU), 91054 Erlangen, Germany.
Wendland K; Department of Internal Medicine 5, Haematology and Oncology, University Hospital of Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg (FAU), 91054 Erlangen, Germany.
Petkovic S; Department of Internal Medicine 5, Haematology and Oncology, University Hospital of Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg (FAU), 91054 Erlangen, Germany.
Emmerich C; Department of Internal Medicine 5, Haematology and Oncology, University Hospital of Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg (FAU), 91054 Erlangen, Germany.
Erber R; Department of Pathology, University Hospital of Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg (FAU), 91054 Erlangen, Germany.
Geppert C; Department of Pathology, University Hospital of Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg (FAU), 91054 Erlangen, Germany.
Hartmann A; Department of Pathology, University Hospital of Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg (FAU), 91054 Erlangen, Germany.
Mackensen A; Department of Internal Medicine 5, Haematology and Oncology, University Hospital of Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg (FAU), 91054 Erlangen, Germany.
Nitschke L; Department of Biology, Friedrich-Alexander University of Erlangen-Nuremberg (FAU), 91054 Erlangen, Germany.
Müller F; Department of Internal Medicine 5, Haematology and Oncology, University Hospital of Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg (FAU), 91054 Erlangen, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 28; Vol. 22 (19). Date of Electronic Publication: 2021 Sep 28.
Typ publikacji :
Journal Article
MeSH Terms :
Immunotherapy*
Lymphoma*/genetics
Lymphoma*/immunology
Lymphoma*/therapy
Neoplasm Proteins*/genetics
Neoplasm Proteins*/immunology
Neoplasms, Experimental*/genetics
Neoplasms, Experimental*/immunology
Neoplasms, Experimental*/therapy
Sialic Acid Binding Ig-like Lectin 2*/genetics
Sialic Acid Binding Ig-like Lectin 2*/immunology
Tumor Microenvironment*/genetics
Tumor Microenvironment*/immunology
Animals ; Humans ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Mice, Transgenic ; Organ Specificity/genetics ; Organ Specificity/immunology
Czasopismo naukowe
Tytuł :
2-Hexyl-4-Pentylenic Acid (HPTA) Stimulates the Radiotherapy-induced Abscopal Effect on Distal Tumor through Polarization of Tumor-associated Macrophages.
Autorzy :
Duan WH; Department of Occupational Health and Occupational Medicine, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.
Jin LY; Department of Occupational Health and Occupational Medicine, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.
Cai ZC; Department of Occupational Health and Occupational Medicine, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.
Lim D; School of Health Sciences, Western Sydney University, Campbelltown 2560, Australia.
Feng ZH; Department of Occupational Health and Occupational Medicine, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.
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Źródło :
Biomedical and environmental sciences : BES [Biomed Environ Sci] 2021 Sep 20; Vol. 34 (9), pp. 693-704.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Fatty Acids, Unsaturated/*therapeutic use
Mammary Neoplasms, Experimental/*drug therapy
Mammary Neoplasms, Experimental/*radiotherapy
Animals ; Antineoplastic Agents/pharmacology ; Cell Proliferation/drug effects ; Cell Proliferation/radiation effects ; Combined Modality Therapy ; Cytokines/immunology ; Fatty Acids, Unsaturated/pharmacology ; Female ; Mammary Neoplasms, Experimental/immunology ; Rats ; Tumor-Associated Macrophages/drug effects ; Tumor-Associated Macrophages/radiation effects
Czasopismo naukowe
Tytuł :
A New Perspective on Cancer Therapy: Changing the Treaded Path?
Autorzy :
Baidoo JNE; Department of Chemistry, The College of Staten Island, City University of New York, Staten Island, NY 10314, USA.; Doctoral Program in Biochemistry, The Graduate Center of the City University of New York, New York, NY 10016, USA.
Mukherjee S; Department of Chemistry, The College of Staten Island, City University of New York, Staten Island, NY 10314, USA.; Doctoral Program in Biochemistry, The Graduate Center of the City University of New York, New York, NY 10016, USA.
Kashfi K; Department of Molecular, Cellular, and Biomedical Sciences, Sophie Davis School of Biomedical Education, City University of New York School of Medicine, New York, NY 10031, USA.; Graduate Program in Biology, City University of New York Graduate Center, New York, NY 10016, USA.
Banerjee P; Department of Chemistry, The College of Staten Island, City University of New York, Staten Island, NY 10314, USA.; Doctoral Program in Biochemistry, The Graduate Center of the City University of New York, New York, NY 10016, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 11; Vol. 22 (18). Date of Electronic Publication: 2021 Sep 11.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Curcumin/*therapeutic use
Glioblastoma/*drug therapy
Neoplasms, Experimental/*drug therapy
Uterine Cervical Neoplasms/*drug therapy
Animals ; Female ; Glioblastoma/immunology ; Glioblastoma/pathology ; Humans ; Killer Cells, Natural/immunology ; Killer Cells, Natural/pathology ; Mice ; Neoplasms, Experimental/immunology ; Neoplasms, Experimental/pathology ; Nitric Oxide/immunology ; T-Lymphocytes, Cytotoxic/immunology ; T-Lymphocytes, Cytotoxic/pathology ; Tumor-Associated Macrophages/immunology ; Tumor-Associated Macrophages/pathology ; Uterine Cervical Neoplasms/immunology ; Uterine Cervical Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Petasin potently inhibits mitochondrial complex I-based metabolism that supports tumor growth and metastasis.
Autorzy :
Heishima K; The United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Gifu, Japan.
Sugito N; The United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Gifu, Japan.
Soga T; Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan.
Nishikawa M; The United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Gifu, Japan.
Ito Y; Department of Anatomy and Cell Biology, Division of Life Sciences, Osaka Medical College, Takatsuki, Osaka, Japan.
Honda R; The United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Gifu, Japan.
Kuranaga Y; The United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Gifu, Japan.
Sakai H; Laboratory of Veterinary Pathology, Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Gifu, Japan.
Ito R; CCI Holdings Inc., Seki, Gifu, Japan.
Nakagawa T; Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo, Tokyo, Japan.
Ueda H; The United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Gifu, Japan.
Akao Y; The United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Gifu, Japan.
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2021 Sep 01; Vol. 131 (17).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents, Phytogenic/*pharmacology
Electron Transport Complex I/*antagonists & inhibitors
Neoplasms, Experimental/*drug therapy
Neoplasms, Experimental/*metabolism
Sesquiterpenes/*pharmacology
Adenosine Triphosphate/metabolism ; Animals ; Antineoplastic Agents, Phytogenic/chemistry ; Cell Line, Tumor ; Electron Transport Complex I/metabolism ; Endoplasmic Reticulum Stress/drug effects ; Female ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism ; Lung Neoplasms/secondary ; Metabolome/drug effects ; Metformin/pharmacology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Nude ; Neoplasm Metastasis/prevention & control ; Neoplasms, Experimental/pathology ; Petasites/chemistry ; Phenformin/pharmacology ; Sesquiterpenes/chemistry ; Unfolded Protein Response/drug effects ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Pharmacological inhibition of IRAK1 attenuates colitis-induced tumorigenesis in mice by inhibiting the inflammatory response and epithelial-mesenchymal transition.
Autorzy :
Feng Z; Department of Colorectal Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.; No. 1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Duan Z; Department of Colorectal Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.; No. 1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Shi G; No. 1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Wang Q; Central Laboratory, Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, China.
Zhou J; Central Laboratory, Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, China.
Chen Y; Department of Colorectal Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
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Źródło :
Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2021 Sep; Vol. 35 (9), pp. e22838. Date of Electronic Publication: 2021 Jul 17.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinogenesis/*drug effects
Colitis/*drug therapy
Colitis-Associated Neoplasms/*drug therapy
Epithelial-Mesenchymal Transition/*drug effects
Interleukin-1 Receptor-Associated Kinases/*antagonists & inhibitors
Neoplasm Proteins/*antagonists & inhibitors
Neoplasms, Experimental/*drug therapy
Protein Kinase Inhibitors/*pharmacology
Animals ; Carcinogenesis/chemically induced ; Carcinogenesis/metabolism ; Colitis/chemically induced ; Colitis/enzymology ; Colitis-Associated Neoplasms/chemically induced ; Colitis-Associated Neoplasms/enzymology ; Inflammation/chemically induced ; Inflammation/drug therapy ; Inflammation/enzymology ; Interleukin-1 Receptor-Associated Kinases/metabolism ; Male ; Mice ; Neoplasm Proteins/metabolism ; Neoplasms, Experimental/chemically induced ; Neoplasms, Experimental/enzymology
Czasopismo naukowe
Tytuł :
Anti-breast cancer potential of Anonidium mannii (Oliv.) Engl. & Diels barks ethanolic extract: UPLC-ESI-QTOF-MS detection of anticancer alkaloids.
Autorzy :
Mefegue FA; Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé 1, P.O. Box 812, Yaounde, Cameroon.
Michel T; Institute of Chemistry of Nice, Université Côte D'Azur, UMR CNRS 7272, Valrose Park, F-06108, Nice Cedex 2, France.
Kamto ELD; Department of Organic Chemistry, Faculty of Science, University of Yaounde 1, P.O. Box 812, Yaounde, Cameroon.
Kenmogne LV; Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé 1, P.O. Box 812, Yaounde, Cameroon.
Awounfack CF; Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé 1, P.O. Box 812, Yaounde, Cameroon.
Noundou XS; Department of Chemistry, Faculty of Science, Rhodes University, Grahamstown, 6140, South Africa.
Ndinteh DT; Department of Chemical Sciences, Faculty of Science, University of Johannesburg, Doornfontein, 2028, South Africa.
Njamen D; Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé 1, P.O. Box 812, Yaounde, Cameroon; Department of Chemical Sciences, Faculty of Science, University of Johannesburg, Doornfontein, 2028, South Africa. Electronic address: .
Zingue S; Department of Chemical Sciences, Faculty of Science, University of Johannesburg, Doornfontein, 2028, South Africa; Department of Medical and Biomedical Engineering, Higher Technical Teachers' Training College, University of Yaoundé 1, P.O. Box 886, Ebolowa, Cameroon; Department of Life and Earth Sciences, Higher Teachers' Training College, University of Maroua, P.O. Box 55, Maroua, Cameroon. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 Aug 10; Vol. 276, pp. 114131. Date of Electronic Publication: 2021 Apr 21.
Typ publikacji :
Journal Article
MeSH Terms :
Alkaloids/*pharmacology
Annonaceae/*chemistry
Antineoplastic Agents, Phytogenic/*pharmacology
Antioxidants/*pharmacology
Mammary Neoplasms, Experimental/*prevention & control
Plant Extracts/*pharmacology
Alkaloids/therapeutic use ; Animals ; Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/therapeutic use ; Antineoplastic Agents, Phytogenic/toxicity ; Antioxidants/chemistry ; Antioxidants/therapeutic use ; Antioxidants/toxicity ; Cameroon ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Chromatography, High Pressure Liquid ; Ethanol/chemistry ; Female ; Humans ; Mammary Neoplasms, Experimental/blood ; Mammary Neoplasms, Experimental/pathology ; Medicine, Traditional ; Minerals/analysis ; Organ Size/drug effects ; Oxidative Stress/drug effects ; Plant Bark/chemistry ; Plant Extracts/chemistry ; Plant Extracts/therapeutic use ; Plant Extracts/toxicity ; Rats, Wistar ; Spectrometry, Mass, Electrospray Ionization ; Tamoxifen/therapeutic use ; Tumor Burden/drug effects
Czasopismo naukowe
Tytuł :
Lymphoid Organ Proteomes Identify Therapeutic Efficacy Biomarkers Following the Intracavitary Administration of Curcumin in a Highly Invasive Rat Model of Peritoneal Mesothelioma.
Autorzy :
Pouliquen DL; Université d'Angers, Inserm, CRCINA, F-49000 Angers, France.
Boissard A; Université d'Angers, ICO Cancer Center, Inserm, CRCINA, F-49000 Angers, France.
Henry C; Université d'Angers, ICO Cancer Center, Inserm, CRCINA, F-49000 Angers, France.
Blandin S; Université de Nantes, Plate-Forme MicroPICell, SFR François Bonamy, F-44000 Nantes, France.
Coqueret O; Université d'Angers, Inserm, CRCINA, F-49000 Angers, France.
Guette C; Université d'Angers, ICO Cancer Center, Inserm, CRCINA, F-49000 Angers, France.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 09; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 09.
Typ publikacji :
Journal Article
MeSH Terms :
Mesothelioma*/drug therapy
Mesothelioma*/metabolism
Mesothelioma*/pathology
Neoplasms, Experimental*/drug therapy
Neoplasms, Experimental*/metabolism
Neoplasms, Experimental*/pathology
Peritoneal Neoplasms*/drug therapy
Peritoneal Neoplasms*/metabolism
Peritoneal Neoplasms*/pathology
Biomarkers, Tumor/*metabolism
Curcumin/*pharmacology
Lymph Nodes/*metabolism
Neoplasm Proteins/*metabolism
Proteome/*metabolism
Animals ; Male ; Neoplasm Invasiveness ; Rats ; Rats, Inbred F344
Czasopismo naukowe
Tytuł :
Tea tree oil extract causes mitochondrial superoxide production and apoptosis as an anticancer agent, promoting tumor infiltrating neutrophils cytotoxic for breast cancer to induce tumor regression.
Autorzy :
Clark AM; School of Pharmacy and Medical Science, Menzies Health Institute of Queensland, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia.
Magawa C; School of Pharmacy and Medical Science, Menzies Health Institute of Queensland, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia.
Pliego-Zamora A; School of Pharmacy and Medical Science, Menzies Health Institute of Queensland, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia.
Low P; School of Pharmacy and Medical Science, Menzies Health Institute of Queensland, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia.
Reynolds M; School of Pharmacy and Medical Science, Menzies Health Institute of Queensland, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia; Australian Botanical Bioscience Pty. Ltd., Australia.
Ralph SJ; School of Pharmacy and Medical Science, Menzies Health Institute of Queensland, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Aug; Vol. 140, pp. 111790. Date of Electronic Publication: 2021 Jun 11.
Typ publikacji :
Journal Article
MeSH Terms :
Melaleuca*
Antineoplastic Agents/*therapeutic use
Mammary Neoplasms, Experimental/*drug therapy
Tea Tree Oil/*therapeutic use
Animals ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Cell Cycle/drug effects ; Cell Line, Tumor ; Chlorocebus aethiops ; Female ; Humans ; Mammary Neoplasms, Experimental/immunology ; Mammary Neoplasms, Experimental/metabolism ; Mammary Neoplasms, Experimental/pathology ; Mice, Transgenic ; Mitochondria/drug effects ; Mitochondria/metabolism ; Neutrophils/drug effects ; Neutrophils/immunology ; Plant Extracts ; Reactive Oxygen Species/metabolism ; Superoxides/metabolism ; Tea Tree Oil/pharmacology ; Vero Cells
Czasopismo naukowe
Tytuł :
Modeling pancreatic cancer in mice for experimental therapeutics.
Autorzy :
Mallya K; Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA.
Gautam SK; Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA. Electronic address: .
Aithal A; Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA.
Batra SK; Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.
Jain M; Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Reviews on cancer [Biochim Biophys Acta Rev Cancer] 2021 Aug; Vol. 1876 (1), pp. 188554. Date of Electronic Publication: 2021 May 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Immunotherapy*
Antineoplastic Agents/*pharmacology
Carcinoma, Pancreatic Ductal/*therapy
Neoplasms, Experimental/*therapy
Pancreatic Neoplasms/*therapy
Animals ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/metabolism ; Carcinoma, Pancreatic Ductal/pathology ; Cell Line, Tumor ; Drug Resistance, Neoplasm ; Genetic Predisposition to Disease ; Mice, Transgenic ; Neoplasms, Experimental/genetics ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/pathology ; Phenotype ; Species Specificity ; Tumor Microenvironment ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Saxagliptin defers thioacetamide-induced hepatocarcinogenesis in rats: A novel suppressive impact on Wnt/Hedgehog/Notch1 signaling.
Autorzy :
Abd Elhameed AG; Dep. of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt; Dep. of Pharmacology, Faculty of Pharmacy, Horus University-Egypt, New Damietta, Egypt.
Helal MG; Dep. of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
Said E; Dep. of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt. Electronic address: .
Salem HA; Dep. of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
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Źródło :
Environmental toxicology and pharmacology [Environ Toxicol Pharmacol] 2021 Aug; Vol. 86, pp. 103668. Date of Electronic Publication: 2021 May 01.
Typ publikacji :
Journal Article
MeSH Terms :
Adamantane/*analogs & derivatives
Carcinoma, Hepatocellular/*drug therapy
Dipeptides/*therapeutic use
Dipeptidyl-Peptidase IV Inhibitors/*therapeutic use
Liver Neoplasms/*drug therapy
Liver Neoplasms, Experimental/*drug therapy
Adamantane/pharmacology ; Adamantane/therapeutic use ; Animals ; Apoptosis/drug effects ; Carcinoma, Hepatocellular/chemically induced ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Cell Proliferation/drug effects ; Dipeptides/pharmacology ; Dipeptidyl-Peptidase IV Inhibitors/pharmacology ; Hedgehog Proteins/metabolism ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Liver Neoplasms, Experimental/metabolism ; Liver Neoplasms, Experimental/pathology ; Male ; Rats, Sprague-Dawley ; Receptor, Notch1/metabolism ; Thioacetamide ; Wnt Signaling Pathway/drug effects
Czasopismo naukowe
Tytuł :
Chemopreventive Effect of Cratoxylum formosum (Jack) ssp. pruniflorum on Initial Stage Hepatocarcinogenesis in Rats.
Autorzy :
Pocasap P; Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.; Human High Performance and Health Promotion Research Institute, Khon Kaen University, Khon Kaen 40002, Thailand.
Weerapreeyakul N; Human High Performance and Health Promotion Research Institute, Khon Kaen University, Khon Kaen 40002, Thailand.; Division of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand.
Wongpoomchai R; Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.; Research Center for Development of Local Lanna Rice and Rice Products, Chiang Mai University, Chiang Mai 50200, Thailand.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Jul 12; Vol. 26 (14). Date of Electronic Publication: 2021 Jul 12.
Typ publikacji :
Journal Article
MeSH Terms :
Anticarcinogenic Agents/*pharmacology
Carcinogenesis/*drug effects
Carcinoma, Hepatocellular/*drug therapy
Clusiaceae/*chemistry
Liver/*drug effects
Liver Neoplasms/*drug therapy
Liver Neoplasms, Experimental/*drug therapy
Animals ; Carcinogens/pharmacology ; Carcinoma, Hepatocellular/chemically induced ; Carcinoma, Hepatocellular/metabolism ; Diethylnitrosamine/pharmacology ; Glutathione Transferase/metabolism ; Liver/metabolism ; Liver Neoplasms/chemically induced ; Liver Neoplasms, Experimental/chemically induced ; Liver Neoplasms, Experimental/metabolism ; Male ; Proliferating Cell Nuclear Antigen/metabolism ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Stress-Inducible Gene Atf3 Dictates a Dichotomous Macrophage Activity in Chemotherapy-Enhanced Lung Colonization.
Autorzy :
Middleton JD; Department of Biological Chemistry and Pharmacology, College of Medicine, Ohio State University, Columbus, OH 43210, USA.; Molecular, Cellular and Developmental Biology Program, Ohio State University, Columbus, OH 43210, USA.
Fehlman J; Department of Biological Chemistry and Pharmacology, College of Medicine, Ohio State University, Columbus, OH 43210, USA.
Sivakumar S; Department of Biological Chemistry and Pharmacology, College of Medicine, Ohio State University, Columbus, OH 43210, USA.
Stover DG; Department of Internal Medicine, College of Medicine, Ohio State University, Columbus, OH 43210, USA.
Hai T; Department of Biological Chemistry and Pharmacology, College of Medicine, Ohio State University, Columbus, OH 43210, USA.; Molecular, Cellular and Developmental Biology Program, Ohio State University, Columbus, OH 43210, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 08; Vol. 22 (14). Date of Electronic Publication: 2021 Jul 08.
Typ publikacji :
Journal Article
MeSH Terms :
Activating Transcription Factor 3/*physiology
Cyclophosphamide/*toxicity
Lung Neoplasms/*secondary
Macrophages/*physiology
Mammary Neoplasms, Experimental/*genetics
Neoplasm Metastasis/*physiopathology
Neoplasm Proteins/*physiology
Stress, Physiological/*genetics
Tumor-Associated Macrophages/*physiology
Animals ; Antimicrobial Cationic Peptides/biosynthesis ; Antimicrobial Cationic Peptides/genetics ; Cell Line, Tumor ; Cyclophosphamide/pharmacology ; Gene Expression Regulation, Neoplastic/drug effects ; Genes, Reporter ; Genotype ; Humans ; Lung Neoplasms/metabolism ; Macrophage Activation ; Mammary Neoplasms, Experimental/drug therapy ; Mammary Neoplasms, Experimental/pathology ; Mice ; Mice, Inbred C57BL ; Mice, Inbred Strains ; Mice, Knockout ; Mice, Transgenic ; Neoadjuvant Therapy/adverse effects ; Neoplasm Metastasis/genetics ; Neoplasm Proteins/biosynthesis ; Neoplasm Proteins/genetics ; Neoplasm Transplantation/methods ; Neoplastic Stem Cells/pathology ; Transendothelial and Transepithelial Migration ; Tumor Microenvironment ; Tumor-Associated Macrophages/drug effects
Czasopismo naukowe

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