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Wyszukujesz frazę ""Neoplastic Stem Cells"" wg kryterium: Temat


Tytuł:
Modified Shenlingbaizhu Decoction represses the pluripotency of colorectal cancer stem cells by inhibiting TGF-β mediated EMT program.
Autorzy:
Dai Y; The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Wang H; The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Sun R; The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Diao J; The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Ma Y; The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Shao M; The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Xu Y; The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Zhang Q; The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Gao Z; The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China; Shunde Hospital, Guangzhou University of Chinese Medicine, Foshan, 528333, Guangdong, China.
Zeng Z; The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Zhang L; Traditional Chinese Medicine Integrated Hospital, Southern Medical University, Guangzhou, 510315, Guangdong, China.
Sun X; The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China; Department of traditional Chinese medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, 510260, Guangdong, China. Electronic address: sxg_.
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Źródło:
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2022 Aug; Vol. 103, pp. 154234. Date of Electronic Publication: 2022 Jun 01.
Typ publikacji:
Journal Article
MeSH Terms:
Colorectal Neoplasms*/blood
Colorectal Neoplasms*/drug therapy
Colorectal Neoplasms*/metabolism
Colorectal Neoplasms*/pathology
Drugs, Chinese Herbal*/pharmacology
Neoplastic Stem Cells*/drug effects
Neoplastic Stem Cells*/metabolism
Neoplastic Stem Cells*/pathology
Pluripotent Stem Cells*/drug effects
Pluripotent Stem Cells*/metabolism
Pluripotent Stem Cells*/pathology
Transforming Growth Factor beta1*/antagonists & inhibitors
Transforming Growth Factor beta1*/blood
Animals ; Cell Line, Tumor ; Cell Movement/drug effects ; Epithelial-Mesenchymal Transition/drug effects ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Phytotherapy
Czasopismo naukowe
Tytuł:
A novel nitidine chloride nanoparticle overcomes the stemness of CD133 Huh7 hepatocellular carcinoma cells for liver cancer therapy.
Autorzy:
Li D; School of Chemistry and Chemical Eengineering, Guangxi Minzu University, No.158, Da Xue Xi street, Xixiangtang District, Nanning, 530006, Guangxi Province, China. .
Zhang Q; School of Chemistry and Chemical Eengineering, Guangxi Minzu University, No.158, Da Xue Xi street, Xixiangtang District, Nanning, 530006, Guangxi Province, China.
Zhou Y; School of Chemistry and Chemical Eengineering, Guangxi Minzu University, No.158, Da Xue Xi street, Xixiangtang District, Nanning, 530006, Guangxi Province, China.
Zhu H; College of Pharmacy, Guangxi University for Chinese Medicine, No.13 , Wu He street, Qingxiu District, Nanning, 530200, Guangxi Province, China.
Li T; College of Pharmacy, Guangxi University for Chinese Medicine, No.13 , Wu He street, Qingxiu District, Nanning, 530200, Guangxi Province, China.
Du F; School of Chemistry and Chemical Eengineering, Guangxi Minzu University, No.158, Da Xue Xi street, Xixiangtang District, Nanning, 530006, Guangxi Province, China.
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Źródło:
BMC pharmacology & toxicology [BMC Pharmacol Toxicol] 2022 Jul 12; Vol. 23 (1), pp. 48. Date of Electronic Publication: 2022 Jul 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma, Hepatocellular*/drug therapy
Carcinoma, Hepatocellular*/metabolism
Carcinoma, Hepatocellular*/pathology
Liver Neoplasms*/drug therapy
Liver Neoplasms*/metabolism
Liver Neoplasms*/pathology
Nanoparticles*/administration & dosage
Neoplastic Stem Cells*/metabolism
Neoplastic Stem Cells*/pathology
AC133 Antigen/metabolism ; Animals ; Benzophenanthridines ; Cell Line, Tumor ; Epithelial Cell Adhesion Molecule ; Humans ; Mice ; Mice, Nude
Czasopismo naukowe
Tytuł:
Survivin Inhibition by Piperine Sensitizes Glioblastoma Cancer Stem Cells and Leads to Better Drug Response.
Autorzy:
Warrier NM; Department of Biotechnology, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.
Krishnan RK; Department of Medicine II, Hematology and Oncology, University Hospital Frankfurt, Goethe University, 60590 Frankfurt, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Prabhu V; Department of Biotechnology, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.
Hariharapura RC; Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.
Agarwal P; National Bioinformatics Infrastructure Sweden (NBIS), SciLifeLab, Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, 22362 Lund, Sweden.
Kumar P; Department of Biotechnology, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jul 09; Vol. 23 (14). Date of Electronic Publication: 2022 Jul 09.
Typ publikacji:
Journal Article
MeSH Terms:
Brain Neoplasms*/drug therapy
Brain Neoplasms*/genetics
Brain Neoplasms*/metabolism
Cytochrome P-450 Enzyme Inhibitors*/pharmacology
Glioblastoma*/drug therapy
Glioblastoma*/genetics
Glioblastoma*/metabolism
Neoplastic Stem Cells*/drug effects
Neoplastic Stem Cells*/metabolism
Piperidines*/pharmacology
Survivin*/genetics
Survivin*/metabolism
Alkaloids/pharmacology ; Benzodioxoles/pharmacology ; Cell Line, Tumor ; Humans ; Polyunsaturated Alkamides/pharmacology
Czasopismo naukowe
Tytuł:
PITX2C increases the stemness features of hepatocellular carcinoma cells by up-regulating key developmental factors in liver progenitor.
Autorzy:
Jiang L; Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, People's Republic of China. .; Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Room L10-56, Laboratory Block, 21 Sassoon Road, Pokfulam, Hong Kong, China. .; Research Institute of Pancreatic Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China. .
Wang X; Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Room L10-56, Laboratory Block, 21 Sassoon Road, Pokfulam, Hong Kong, China.; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong, China.
Ma F; Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, People's Republic of China.; Research Institute of Pancreatic Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wang X; Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, People's Republic of China.; Research Institute of Pancreatic Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shi M; Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, People's Republic of China.; Research Institute of Pancreatic Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yan Q; Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Room L10-56, Laboratory Block, 21 Sassoon Road, Pokfulam, Hong Kong, China.; Department of Colorectal Surgery, Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Liu M; Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Room L10-56, Laboratory Block, 21 Sassoon Road, Pokfulam, Hong Kong, China.; Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.
Chen J; Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Room L10-56, Laboratory Block, 21 Sassoon Road, Pokfulam, Hong Kong, China.
Shi C; Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Room L10-56, Laboratory Block, 21 Sassoon Road, Pokfulam, Hong Kong, China.
Guan XY; Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Room L10-56, Laboratory Block, 21 Sassoon Road, Pokfulam, Hong Kong, China. .; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong, China. .
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2022 Jun 28; Vol. 41 (1), pp. 211. Date of Electronic Publication: 2022 Jun 28.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Hepatocellular*/genetics
Carcinoma, Hepatocellular*/pathology
Liver*/metabolism
Liver*/pathology
Liver Neoplasms*/genetics
Liver Neoplasms*/pathology
Neoplastic Stem Cells*/metabolism
Neoplastic Stem Cells*/pathology
Stem Cells*/metabolism
Stem Cells*/pathology
Transcription Factors*/genetics
Transcription Factors*/metabolism
Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Humans ; Lipopolysaccharides ; Up-Regulation
Czasopismo naukowe
Tytuł:
Glioma-associated mesenchymal stem cells-mediated PD-L1 expression is attenuated by Ad5-Ki67/IL-15 in GBM treatment.
Autorzy:
Zhang Q; Brain Tumor Research Center, Beijing Neurosurgical Institute, Capital Medical University, Beijing, 100070, People's Republic of China.; Department of Neurosurgery, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing, 100070, People's Republic of China.; Beijing Laboratory of Biomedical Materials, Beijing, 100070, People's Republic of China.
Zhang J; Brain Tumor Research Center, Beijing Neurosurgical Institute, Capital Medical University, Beijing, 100070, People's Republic of China.; Department of Neurosurgery, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing, 100070, People's Republic of China.; Beijing Laboratory of Biomedical Materials, Beijing, 100070, People's Republic of China.
Wang P; Brain Tumor Research Center, Beijing Neurosurgical Institute, Capital Medical University, Beijing, 100070, People's Republic of China.; Department of Neurosurgery, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing, 100070, People's Republic of China.; Beijing Laboratory of Biomedical Materials, Beijing, 100070, People's Republic of China.
Zhu G; Brain Tumor Research Center, Beijing Neurosurgical Institute, Capital Medical University, Beijing, 100070, People's Republic of China.; Department of Neurosurgery, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing, 100070, People's Republic of China.; Beijing Laboratory of Biomedical Materials, Beijing, 100070, People's Republic of China.
Jin G; Brain Tumor Research Center, Beijing Neurosurgical Institute, Capital Medical University, Beijing, 100070, People's Republic of China.; Department of Neurosurgery, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing, 100070, People's Republic of China.; Beijing Laboratory of Biomedical Materials, Beijing, 100070, People's Republic of China.
Liu F; Brain Tumor Research Center, Beijing Neurosurgical Institute, Capital Medical University, Beijing, 100070, People's Republic of China. .; Department of Neurosurgery, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing, 100070, People's Republic of China. .; Beijing Laboratory of Biomedical Materials, Beijing, 100070, People's Republic of China. .
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Źródło:
Stem cell research & therapy [Stem Cell Res Ther] 2022 Jun 28; Vol. 13 (1), pp. 284. Date of Electronic Publication: 2022 Jun 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
B7-H1 Antigen*/biosynthesis
B7-H1 Antigen*/genetics
B7-H1 Antigen*/metabolism
Glioblastoma*/genetics
Glioblastoma*/metabolism
Glioblastoma*/pathology
Glioblastoma*/therapy
Glioma*/pathology
Interleukin-15*/metabolism
Ki-67 Antigen*/metabolism
Mesenchymal Stem Cells*/metabolism
Mesenchymal Stem Cells*/pathology
Neoplastic Stem Cells*/metabolism
Neoplastic Stem Cells*/pathology
Animals ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Mice ; Mice, Nude ; Tumor Microenvironment
Czasopismo naukowe
Tytuł:
Tumor-associated macrophages promote epithelial-mesenchymal transition and the cancer stem cell properties in triple-negative breast cancer through CCL2/AKT/β-catenin signaling.
Autorzy:
Chen X; Guangzhou Key Laboratory of 'Translational Medicine on Malignant Tumor Treatment', Affiliated Cancer Hospital & Institute of Guangzhou Medical University, No.78 Hengzhigang Road, Guangzhou, 510095, Guangdong, China.
Yang M; Guangzhou Key Laboratory of 'Translational Medicine on Malignant Tumor Treatment', Affiliated Cancer Hospital & Institute of Guangzhou Medical University, No.78 Hengzhigang Road, Guangzhou, 510095, Guangdong, China.
Yin J; Guangzhou Key Laboratory of 'Translational Medicine on Malignant Tumor Treatment', Affiliated Cancer Hospital & Institute of Guangzhou Medical University, No.78 Hengzhigang Road, Guangzhou, 510095, Guangdong, China.
Li P; Guangzhou Key Laboratory of 'Translational Medicine on Malignant Tumor Treatment', Affiliated Cancer Hospital & Institute of Guangzhou Medical University, No.78 Hengzhigang Road, Guangzhou, 510095, Guangdong, China.
Zeng S; Guangzhou Key Laboratory of 'Translational Medicine on Malignant Tumor Treatment', Affiliated Cancer Hospital & Institute of Guangzhou Medical University, No.78 Hengzhigang Road, Guangzhou, 510095, Guangdong, China.
Zheng G; Guangzhou Key Laboratory of 'Translational Medicine on Malignant Tumor Treatment', Affiliated Cancer Hospital & Institute of Guangzhou Medical University, No.78 Hengzhigang Road, Guangzhou, 510095, Guangdong, China.
He Z; Guangzhou Key Laboratory of 'Translational Medicine on Malignant Tumor Treatment', Affiliated Cancer Hospital & Institute of Guangzhou Medical University, No.78 Hengzhigang Road, Guangzhou, 510095, Guangdong, China.
Liu H; Guangzhou Key Laboratory of 'Translational Medicine on Malignant Tumor Treatment', Affiliated Cancer Hospital & Institute of Guangzhou Medical University, No.78 Hengzhigang Road, Guangzhou, 510095, Guangdong, China.
Wang Q; Guangzhou Key Laboratory of 'Translational Medicine on Malignant Tumor Treatment', Affiliated Cancer Hospital & Institute of Guangzhou Medical University, No.78 Hengzhigang Road, Guangzhou, 510095, Guangdong, China. .
Zhang F; Department of Pharmacy, Renmin Hospital of Wuhan University, No.99 Zhangzhidong Road, Wuhan, 430000, Hubei, China. .
Chen D; Guangzhou Key Laboratory of 'Translational Medicine on Malignant Tumor Treatment', Affiliated Cancer Hospital & Institute of Guangzhou Medical University, No.78 Hengzhigang Road, Guangzhou, 510095, Guangdong, China. .
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Źródło:
Cell communication and signaling : CCS [Cell Commun Signal] 2022 Jun 17; Vol. 20 (1), pp. 92. Date of Electronic Publication: 2022 Jun 17.
Typ publikacji:
Journal Article; Video-Audio Media; Research Support, Non-U.S. Gov't
MeSH Terms:
Chemokine CCL2*/metabolism
Epithelial-Mesenchymal Transition*
Neoplastic Stem Cells*/metabolism
Neoplastic Stem Cells*/pathology
Proto-Oncogene Proteins c-akt*/metabolism
Triple Negative Breast Neoplasms*/metabolism
Triple Negative Breast Neoplasms*/pathology
Tumor-Associated Macrophages*/metabolism
Tumor-Associated Macrophages*/pathology
beta Catenin*/metabolism
Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Humans ; Signal Transduction ; Tumor Microenvironment
Czasopismo naukowe
Tytuł:
Phenotypic and molecular states of IDH1 mutation-induced CD24-positive glioma stem-like cells.
Autorzy:
Haddock S; Weill Cornell School of Medicine, New York, NY 10021, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Alban TJ; Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH 44022, USA.
Turcan Ş; Neurology Clinic and National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.
Husic H; Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH 44022, USA.
Rosiek E; Department of Molecular Cytology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Ma X; Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH 44022, USA.
Wang Y; Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Bale T; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Desrichard A; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Makarov V; Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH 44022, USA.
Monette S; Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, The Rockefeller University, Weill Cornell Medicine, New York, NY 10065, USA.
Wu W; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Gardner R; Flow Cytometry Core, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Manova K; Department of Molecular Cytology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Boire A; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Chan TA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH 44022, USA; Case Western School of Medicine, Cleveland, OH 44106, USA. Electronic address: .
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Źródło:
Neoplasia (New York, N.Y.) [Neoplasia] 2022 Jun; Vol. 28, pp. 100790. Date of Electronic Publication: 2022 Apr 07.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Brain Neoplasms*/genetics
Brain Neoplasms*/metabolism
Brain Neoplasms*/pathology
Glioma*/genetics
Glioma*/metabolism
Glioma*/pathology
Isocitrate Dehydrogenase*/genetics
Isocitrate Dehydrogenase*/metabolism
Neoplastic Stem Cells*/metabolism
Neoplastic Stem Cells*/pathology
CD24 Antigen/genetics ; CD24 Antigen/metabolism ; Humans ; Mutation ; Phenotype
Czasopismo naukowe
Tytuł:
ARL2 is required for homologous recombination repair and colon cancer stem cell survival.
Autorzy:
Lee H; College of Pharmacy, Sookmyung Women's University, Seoul, Korea.
Choi S; College of Pharmacy, Sookmyung Women's University, Seoul, Korea.
Ha S; College of Pharmacy, Sookmyung Women's University, Seoul, Korea.
Yoon S; Department of Biological Sciences, Sookmyung Women's University, Seoul, Korea.
Kim WY; College of Pharmacy, Sookmyung Women's University, Seoul, Korea.; Research Institute of Pharmacal Research, Sookmyung Women's University, Seoul, Korea.
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Źródło:
FEBS open bio [FEBS Open Bio] 2022 Aug; Vol. 12 (8), pp. 1523-1533. Date of Electronic Publication: 2022 May 24.
Typ publikacji:
Journal Article
MeSH Terms:
Colonic Neoplasms*/genetics
DNA Repair*
GTP-Binding Proteins*/genetics
GTP-Binding Proteins*/metabolism
Neoplastic Stem Cells*/metabolism
Recombinational DNA Repair*/genetics
Humans ; Rad51 Recombinase/genetics ; Rad51 Recombinase/metabolism
Czasopismo naukowe
Tytuł:
A novel CD34-specific T-cell engager efficiently depletes acute myeloid leukemia and leukemic stem cells in vitro and in vivo .
Autorzy:
Arruda LCM; Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm. .
Stikvoort A; Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm.
Lambert M; Center for Hematology and Regenerative Medicine, Department of Medicine, Huddinge, Karolinska Institutet, Stockholm.
Jin L; Princess Margaret Cancer Centre, University Health Network, Toronto.
Rivera LS; Department of Applied Physics, Science for Life Laboratory, KTH Royal Institute of Technology, Stockholm.
Alves RMP; Department of Applied Physics, Science for Life Laboratory, KTH Royal Institute of Technology, Stockholm.
De Moura TR; Department for Biomedical Engineering and Health Systems, KTH Royal Institute of Technology Stockholm.
Mim C; Department for Biomedical Engineering and Health Systems, KTH Royal Institute of Technology Stockholm.
Lehmann S; Center for Hematology and Regenerative Medicine, Department of Medicine, Huddinge, Karolinska Institutet, Stockholm.
Axelsson-Robertson R; Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden; Department of Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm.
Dick JE; Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Department of Molecular Genetics, University of Toronto.
Mattsson J; Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Gloria and Seymour Epstein Chair in Cell Therapy and Transplantation, Princess Margaret Cancer Centre, University Health Network, Toronto.
Önfelt B; Department of Applied Physics, Science for Life Laboratory, KTH Royal Institute of Technology, Stockholm, Sweden; Department of Microbiology, Tumor and Cell Biology, Science for Life Laboratory, Karolinska Institutet, Stockholm.
Carlsten M; Center for Hematology and Regenerative Medicine, Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden; Center for Cell Therapy and Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Stockholm.
Uhlin M; Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden; Department of Applied Physics, Science for Life Laboratory, KTH Royal Institute of Technology, Stockholm, Sweden; Department of Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm.
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Źródło:
Haematologica [Haematologica] 2022 Aug 01; Vol. 107 (8), pp. 1786-1795. Date of Electronic Publication: 2022 Aug 01.
Typ publikacji:
Journal Article
MeSH Terms:
Leukemia, Myeloid, Acute*/pathology
Leukemia, Myeloid, Acute*/therapy
Neoplastic Stem Cells*/pathology
Antigens, CD34 ; Cell Adhesion Molecules ; Humans ; Immunophenotyping ; T-Lymphocytes/pathology
Czasopismo naukowe
Tytuł:
Role of Diet in Stem and Cancer Stem Cells.
Autorzy:
Puca F; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 78705, USA.; Department of Oncology, IRBM Science Park SpA, 00071 Pomezia, Italy.
Fedele M; Institute for Experimental Endocrinology and Oncology (IEOS), National Research Council (CNR), 80131 Naples, Italy.
Rasio D; Department of Clinical and Molecular Medicine, La Sapienza University, 00185 Rome, Italy.
Battista S; Institute for Experimental Endocrinology and Oncology (IEOS), National Research Council (CNR), 80131 Naples, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jul 23; Vol. 23 (15). Date of Electronic Publication: 2022 Jul 23.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Neoplasms*
Neoplastic Stem Cells*
Cell Differentiation/physiology ; Chromosome Segregation ; Diet ; Homeostasis
Czasopismo naukowe
Tytuł:
A Label-Free Cell Sorting Approach to Highlight the Impact of Intratumoral Cellular Heterogeneity and Cancer Stem Cells on Response to Therapies.
Autorzy:
Hervieu C; UMR INSERM 1308-CAPTuR 'Control of Cell Activation in Tumor Progression and Therapeutic Resistance', Ω-Health Institute, Faculty of Medicine, University of Limoges, 87025 Limoges, France.
Verdier M; UMR INSERM 1308-CAPTuR 'Control of Cell Activation in Tumor Progression and Therapeutic Resistance', Ω-Health Institute, Faculty of Medicine, University of Limoges, 87025 Limoges, France.
Barthout E; UMR INSERM 1308-CAPTuR 'Control of Cell Activation in Tumor Progression and Therapeutic Resistance', Ω-Health Institute, Faculty of Medicine, University of Limoges, 87025 Limoges, France.
Bégaud G; UMR INSERM 1308-CAPTuR 'Control of Cell Activation in Tumor Progression and Therapeutic Resistance', Ω-Health Institute, Faculty of Medicine, University of Limoges, 87025 Limoges, France.
Christou N; UMR INSERM 1308-CAPTuR 'Control of Cell Activation in Tumor Progression and Therapeutic Resistance', Ω-Health Institute, Faculty of Medicine, University of Limoges, 87025 Limoges, France.; Department of General, Endocrine and Digestive Surgery, University Hospital of Limoges, 87025 Limoges, France.
Sage M; BISCEm US42 INSERM-UAR 2015 CNRS 'Integrative Biology Health Chemistry Environment', Ω-Health Institute, 87025 Limoges, France.
Pannequin J; UMR 5203 CNRS-INSERM, Institute of Functional Genomics, University of Montpellier, 34094 Montpellier, France.
Battu S; UMR INSERM 1308-CAPTuR 'Control of Cell Activation in Tumor Progression and Therapeutic Resistance', Ω-Health Institute, Faculty of Medicine, University of Limoges, 87025 Limoges, France.
Mathonnet M; UMR INSERM 1308-CAPTuR 'Control of Cell Activation in Tumor Progression and Therapeutic Resistance', Ω-Health Institute, Faculty of Medicine, University of Limoges, 87025 Limoges, France.; Department of General, Endocrine and Digestive Surgery, University Hospital of Limoges, 87025 Limoges, France.
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Źródło:
Cells [Cells] 2022 Jul 22; Vol. 11 (15). Date of Electronic Publication: 2022 Jul 22.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Transformation, Neoplastic*/metabolism
Neoplastic Stem Cells*/pathology
Cell Line, Tumor ; Cell Movement ; Cell Separation ; Humans
Czasopismo naukowe
Tytuł:
Targeting the Leukemic stem cell protein machinery by inhibition of mitochondrial pyrimidine synthesis.
Autorzy:
Donato E; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.
Trumpp A; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.
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Źródło:
EMBO molecular medicine [EMBO Mol Med] 2022 Jul 07; Vol. 14 (7), pp. e16171. Date of Electronic Publication: 2022 Jun 13.
Typ publikacji:
Journal Article
MeSH Terms:
Leukemia, Myeloid, Acute*/drug therapy
Neoplastic Stem Cells*
Humans ; Pyrimidines/pharmacology ; Pyrimidines/therapeutic use
Czasopismo naukowe
Tytuł:
The splicing factor RBM17 drives leukemic stem cell maintenance by evading nonsense-mediated decay of pro-leukemic factors.
Autorzy:
Liu L; Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.; Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Vujovic A; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Deshpande NP; Adult Cancer Program, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.; Prince of Wales Clinical School, University of New South Wales, Sydney, NSW, Australia.
Sathe S; Department of Cellular and Molecular Medicine, Stem Cell Program and Institute for Genomic Medicine, University of California at San Diego, San Diego, CA, USA.
Anande G; Adult Cancer Program, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.; Prince of Wales Clinical School, University of New South Wales, Sydney, NSW, Australia.
Chen HTT; Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Xu J; Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Minden MD; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Yeo GW; Department of Cellular and Molecular Medicine, Stem Cell Program and Institute for Genomic Medicine, University of California at San Diego, San Diego, CA, USA.
Unnikrishnan A; Adult Cancer Program, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.; Prince of Wales Clinical School, University of New South Wales, Sydney, NSW, Australia.
Hope KJ; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. .; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. .
Lu Y; Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada. .
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Źródło:
Nature communications [Nat Commun] 2022 Jul 04; Vol. 13 (1), pp. 3833. Date of Electronic Publication: 2022 Jul 04.
Typ publikacji:
Journal Article
MeSH Terms:
Leukemia, Myeloid, Acute*/metabolism
Neoplastic Stem Cells*/metabolism
RNA Splicing Factors*/genetics
RNA Splicing Factors*/metabolism
Hematopoiesis ; Humans ; Proteomics
Czasopismo naukowe
Tytuł:
CRISPR/Cas9 Screens Reveal that Hexokinase 2 Enhances Cancer Stemness and Tumorigenicity by Activating the ACSL4-Fatty Acid β-Oxidation Pathway.
Autorzy:
Li H; Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Song J; Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
He Y; Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Liu Y; Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Liu Z; Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Sun W; Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, China.
Hu W; Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.; Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, China.
Lei QY; Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Hu X; Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, China.
Chen Z; Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
He X; Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.; Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, China.; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, 211166, China.
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Źródło:
Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2022 Jul; Vol. 9 (21), pp. e2105126. Date of Electronic Publication: 2022 May 23.
Typ publikacji:
Journal Article
MeSH Terms:
Coenzyme A Ligases*/genetics
Coenzyme A Ligases*/metabolism
Hexokinase*/genetics
Hexokinase*/metabolism
Liver Neoplasms*/genetics
Liver Neoplasms*/metabolism
Neoplastic Stem Cells*/metabolism
CRISPR-Cas Systems/genetics ; Fatty Acid-Binding Proteins/genetics ; Fatty Acid-Binding Proteins/metabolism ; Fatty Acids/metabolism ; Humans
Czasopismo naukowe
Tytuł:
FOXF2 oppositely regulates stemness in luminal and basal-like breast cancer cells through the Wnt/beta-catenin pathway.
Autorzy:
Zhang X; Department of Biochemistry and Molecular Biology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin, China.
Zhang R; Department of Biochemistry and Molecular Biology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin, China; Key Laboratory of Breast Cancer Prevention and Therapy of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin, China.
Hou C; Department of Biochemistry and Molecular Biology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin, China.
He R; Department of Biochemistry and Molecular Biology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin, China.
Wang QS; Department of Biochemistry and Molecular Biology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin, China; Key Laboratory of Breast Cancer Prevention and Therapy of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin, China.
Zhou TH; Department of Biochemistry and Molecular Biology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin, China.
Li XQ; Department of Biochemistry and Molecular Biology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin, China; Key Laboratory of Breast Cancer Prevention and Therapy of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin, China.
Zhai QL; Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin, China.
Feng YM; Department of Biochemistry and Molecular Biology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin, China; Key Laboratory of Breast Cancer Prevention and Therapy of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin, China. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2022 Jul; Vol. 298 (7), pp. 102082. Date of Electronic Publication: 2022 May 31.
Typ publikacji:
Journal Article
MeSH Terms:
Breast Neoplasms*/metabolism
Breast Neoplasms*/pathology
Forkhead Transcription Factors*/genetics
Forkhead Transcription Factors*/metabolism
Neoplastic Stem Cells*/pathology
Wnt Signaling Pathway*
Cell Line, Tumor ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Osteogenesis
Czasopismo naukowe
Tytuł:
Leukemic stem cells as a target for eliminating acute myeloid leukemia: Gaps in translational research.
Autorzy:
Khaldoyanidi SK; Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.
Hindoyan A; Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.
Stein A; Gehr Family Leukemia Center, City of Hope, Duarte, CA, USA.
Subklewe M; LMU - University Hospital Munich, Department of Medicine III, Marchioninistrasse 15, 81377 Munich, Germany. Electronic address: .
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Źródło:
Critical reviews in oncology/hematology [Crit Rev Oncol Hematol] 2022 Jul; Vol. 175, pp. 103710. Date of Electronic Publication: 2022 May 16.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Leukemia, Myeloid, Acute*/drug therapy
Neoplastic Stem Cells*/metabolism
Humans ; Neoplasm, Residual/metabolism ; Recurrence ; Translational Research, Biomedical
Czasopismo naukowe
Tytuł:
Cancer cell heterogeneity and plasticity: From molecular understanding to therapeutic targeting.
Autorzy:
Tang DG; Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA. Electronic address: .
Kondo T; Division of Stem Cell Biology, Institute for Genetic Medicine, Hokkaido University, Sapporo, 060-0815, Japan. Electronic address: .
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Źródło:
Seminars in cancer biology [Semin Cancer Biol] 2022 Jul; Vol. 82, pp. 1-2. Date of Electronic Publication: 2021 Oct 06.
Typ publikacji:
Editorial; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Neoplasms*/drug therapy
Neoplasms*/genetics
Neoplastic Stem Cells*
Cell Plasticity ; Humans
Raport
Tytuł:
Chelerythrine Chloride Inhibits Stemness of Melanoma Cancer Stem-Like Cells (CSCs) Potentially via Inducing Reactive Oxygen Species and Causing Mitochondria Dysfunction.
Autorzy:
Li H; Medical Cosmetology Department of Chengdu Second People's Hospital, Chengdu 610041, China.
He M; Medical Cosmetology Department of Chengdu Second People's Hospital, Chengdu 610041, China.
Zhao P; Medical Cosmetology Department of Chengdu Second People's Hospital, Chengdu 610041, China.
Liu P; Medical Cosmetology Department of Chengdu Second People's Hospital, Chengdu 610041, China.
Chen W; Medical Cosmetology Department of Chengdu Second People's Hospital, Chengdu 610041, China.
Xu X; Aesthetic and Plastic Burn Surgery Department of West China Hospital, Sichuan University, Chengdu 610041, China.
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Źródło:
Computational and mathematical methods in medicine [Comput Math Methods Med] 2022 Jun 18; Vol. 2022, pp. 4000733. Date of Electronic Publication: 2022 Jun 18 (Print Publication: 2022).
Typ publikacji:
Journal Article
MeSH Terms:
Melanoma*/drug therapy
Neoplastic Stem Cells*/metabolism
Apoptosis ; Benzophenanthridines ; Cell Line, Tumor ; Cell Proliferation ; Humans ; Mitochondria/metabolism ; Reactive Oxygen Species/metabolism ; Reactive Oxygen Species/pharmacology ; Reactive Oxygen Species/therapeutic use
Czasopismo naukowe
Tytuł:
Nanog, as a key cancer stem cell marker in tumor progression.
Autorzy:
Vasefifar P; Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Motafakkerazad R; Department of Plant Biology, Faculty of Natural Science, University of Tabriz, Iran. Electronic address: .
Maleki LA; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Najafi S; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Ghrobaninezhad F; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Najafzadeh B; Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Alemohammad H; Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Amini M; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Baghbanzadeh A; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Baradaran B; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Pharmaceutical Analysis Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: .
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Źródło:
Gene [Gene] 2022 Jun 15; Vol. 827, pp. 146448. Date of Electronic Publication: 2022 Mar 22.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Nanog Homeobox Protein*/genetics
Nanog Homeobox Protein*/metabolism
Neoplasms*/metabolism
Neoplastic Stem Cells*/metabolism
Carcinogenesis/pathology ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Humans ; Wnt Signaling Pathway
Czasopismo naukowe
Tytuł:
Cutting the umbilical cord: Cancer stem cell-targeted therapeutics.
Autorzy:
Banik A; Department of Biotechnology, Pondicherry University, Chinna Kalapet, Puducherry 605014, India.
Sharma R; Department of Biotechnology, Indian Institute of Technology, Roorkee, Roorkee 247667, India.
Chauhan A; Amity Institute of Physiology and Allied Sciences, Amity University, Noida, India.
Singh S; Amity Institute of Physiology and Allied Sciences, Amity University, Noida, India. Electronic address: .
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Źródło:
Life sciences [Life Sci] 2022 Jun 15; Vol. 299, pp. 120502. Date of Electronic Publication: 2022 Mar 26.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Neoplasms*/drug therapy
Neoplasms*/metabolism
Neoplastic Stem Cells*/metabolism
Humans ; Recurrence ; Tumor Microenvironment ; Umbilical Cord/pathology
Czasopismo naukowe

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