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Wyszukujesz frazę ""Neoplastic Stem Cells"" wg kryterium: Temat


Tytuł :
Dietary Phytochemicals as a Potential Source for Targeting Cancer Stem Cells.
Autorzy :
Manogaran P; Department of Biotechnology, Bharathiar University, Coimbatore, Tamilnadu, India.
Umapathy D; Department of Biochemistry, Bharathidasan University, Tiruchirappalli, Tamilnadu, India.
Karthikeyan M; Department of Biochemistry, Bharathidasan University, Tiruchirappalli, Tamilnadu, India.
Venkatachalam K; Department of Pharmacology & Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
Singaravelu A; Department of PG and Research Department of Biochemistry, Sacred Heart College (Autonomous), Tirupattur, Tamilnadu, India.
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Źródło :
Cancer investigation [Cancer Invest] 2021 Apr; Vol. 39 (4), pp. 349-368. Date of Electronic Publication: 2021 Mar 10.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Diet*/adverse effects
Antineoplastic Agents, Phytogenic/*therapeutic use
Neoplasms/*drug therapy
Neoplastic Stem Cells/*drug effects
Phytochemicals/*therapeutic use
Animals ; Antineoplastic Agents, Phytogenic/adverse effects ; Drug Resistance, Neoplasm ; Humans ; Neoplasms/metabolism ; Neoplasms/pathology ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Phytochemicals/adverse effects ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Dichloroacetate attenuates the stemness of colorectal cancer cells via trigerring ferroptosis through sequestering iron in lysosomes.
Autorzy :
Sun J; Department of Gastroenterology, The Affiliated Suzhou Science and Technology Town Hospital of Nanjing Medical University, Suzhou, Jiangsu, China.
Cheng X; Department of Gastroenterology, The Affiliated Suzhou Science and Technology Town Hospital of Nanjing Medical University, Suzhou, Jiangsu, China.
Pan S; Department of Gastroenterology, The Affiliated Suzhou Science and Technology Town Hospital of Nanjing Medical University, Suzhou, Jiangsu, China.
Wang L; Department of Gastroenterology, The Affiliated Suzhou Science and Technology Town Hospital of Nanjing Medical University, Suzhou, Jiangsu, China.
Dou W; Department of Gastroenterology, The Affiliated Suzhou Science and Technology Town Hospital of Nanjing Medical University, Suzhou, Jiangsu, China.
Liu J; Department of Gastroenterology, The Affiliated Suzhou Science and Technology Town Hospital of Nanjing Medical University, Suzhou, Jiangsu, China.
Shi X; Department of Gastroenterology, The Affiliated Suzhou Science and Technology Town Hospital of Nanjing Medical University, Suzhou, Jiangsu, China.
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Źródło :
Environmental toxicology [Environ Toxicol] 2021 Apr; Vol. 36 (4), pp. 520-529. Date of Electronic Publication: 2020 Nov 09.
Typ publikacji :
Journal Article
MeSH Terms :
Colorectal Neoplasms/*pathology
Dichloroacetic Acid/*pharmacology
Ferroptosis/*drug effects
Iron/*metabolism
Lysosomes/*drug effects
Neoplastic Stem Cells/*drug effects
Sequestering Agents/*pharmacology
Cell Movement/drug effects ; Cell Survival/drug effects ; Colorectal Neoplasms/metabolism ; Dose-Response Relationship, Drug ; HCT116 Cells ; HT29 Cells ; Humans ; Lysosomes/metabolism ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology
Czasopismo naukowe
Tytuł :
In Ovarian Cancer Multicellular Spheroids, Platelet Releasate Promotes Growth, Expansion of ALDH+ and CD133+ Cancer Stem Cells, and Protection against the Cytotoxic Effects of Cisplatin, Carboplatin and Paclitaxel.
Autorzy :
Casagrande N; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italy.
Borghese C; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italy.
Agostini F; Stem Cell Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081 Aviano, Italy.
Durante C; Stem Cell Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081 Aviano, Italy.
Mazzucato M; Stem Cell Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081 Aviano, Italy.
Colombatti A; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italy.
Aldinucci D; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 16; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 16.
Typ publikacji :
Journal Article
MeSH Terms :
AC133 Antigen/*metabolism
Aldehyde Dehydrogenase/*metabolism
Antineoplastic Agents/*pharmacology
Blood Platelets/*metabolism
Cytoprotection/*drug effects
Neoplastic Stem Cells/*pathology
Ovarian Neoplasms/*pathology
Spheroids, Cellular/*pathology
Apoptosis/drug effects ; Blood Platelets/drug effects ; Carboplatin/pharmacology ; Cell Death/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cisplatin/pharmacology ; Female ; Humans ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism ; Paclitaxel/pharmacology ; Spheroids, Cellular/drug effects
Czasopismo naukowe
Tytuł :
IL-6 and IL-8, secreted by myofibroblasts in the tumor microenvironment, activate HES1 to expand the cancer stem cell population in early colorectal tumor.
Autorzy :
Kim B; Department of Medicine, The Graduate School, Yonsei University College of Medicine, Seoul, Korea.; Division of Translational Science, Center for Colon Cancer, Center for Cancer Prevention and Detection, National Cancer Center, Goyang, Korea.; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
Seo Y; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.; Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.
Kwon JH; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
Shin Y; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.; Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.
Kim S; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
Park SJ; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
Park JJ; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.; Yonsei Cancer Prevention Center, Yonsei University College of Medicine, Seoul, Korea.
Cheon JH; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
Kim WH; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
Il Kim T; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.; Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.; Yonsei Cancer Prevention Center, Yonsei University College of Medicine, Seoul, Korea.
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Źródło :
Molecular carcinogenesis [Mol Carcinog] 2021 Mar; Vol. 60 (3), pp. 188-200. Date of Electronic Publication: 2021 Feb 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Colorectal Neoplasms/*pathology
Interleukin-6/*metabolism
Interleukin-8/*metabolism
Neoplastic Stem Cells/*pathology
Transcription Factor HES-1/*metabolism
Caco-2 Cells ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Culture Media, Conditioned/pharmacology ; Gene Expression Regulation, Neoplastic ; Humans ; Myofibroblasts/metabolism ; Myofibroblasts/pathology ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism ; Organoids/pathology ; STAT3 Transcription Factor/antagonists & inhibitors ; STAT3 Transcription Factor/metabolism ; Transcription Factor HES-1/genetics ; Tumor Microenvironment/drug effects
Czasopismo naukowe
Tytuł :
Cell signaling pathways as molecular targets to eliminate AML stem cells.
Autorzy :
Rodrigues ACBDC; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador, Bahia, 40296-710, Brazil.
Costa RGA; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador, Bahia, 40296-710, Brazil.
Silva SLR; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador, Bahia, 40296-710, Brazil.
Dias IRSB; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador, Bahia, 40296-710, Brazil.
Dias RB; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador, Bahia, 40296-710, Brazil.
Bezerra DP; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador, Bahia, 40296-710, Brazil. Electronic address: .
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Źródło :
Critical reviews in oncology/hematology [Crit Rev Oncol Hematol] 2021 Apr; Vol. 160, pp. 103277. Date of Electronic Publication: 2021 Mar 11.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Leukemia, Myeloid, Acute*/drug therapy
Leukemia, Myeloid, Acute*/genetics
Neoplastic Stem Cells*/metabolism
Humans ; NF-kappa B/metabolism ; Phosphatidylinositol 3-Kinases ; Signal Transduction
Czasopismo naukowe
Tytuł :
Carboxy terminus of HSP70-interacting protein (CHIP) attenuates the stemness of thyroid cancer cells through decreasing OCT4 protein stability.
Autorzy :
Xu Y; Department of the Health Management, Neurosurgery, Traditional Chinese Medicine, Nuclear Medicine, Ultrasonic Examination Room, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Xu G; Department of the Health Management, Neurosurgery, Traditional Chinese Medicine, Nuclear Medicine, Ultrasonic Examination Room, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Dang H; Department of the Health Management, Neurosurgery, Traditional Chinese Medicine, Nuclear Medicine, Ultrasonic Examination Room, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Qu W; Department of the Health Management, Neurosurgery, Traditional Chinese Medicine, Nuclear Medicine, Ultrasonic Examination Room, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Chang D; Department of the Health Management, Neurosurgery, Traditional Chinese Medicine, Nuclear Medicine, Ultrasonic Examination Room, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
He X; Department of the Health Management, Neurosurgery, Traditional Chinese Medicine, Nuclear Medicine, Ultrasonic Examination Room, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Li M; Department of the Health Management, Neurosurgery, Traditional Chinese Medicine, Nuclear Medicine, Ultrasonic Examination Room, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Wang Q; Department of the Health Management, Neurosurgery, Traditional Chinese Medicine, Nuclear Medicine, Ultrasonic Examination Room, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
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Źródło :
Environmental toxicology [Environ Toxicol] 2021 Apr; Vol. 36 (4), pp. 686-693. Date of Electronic Publication: 2020 Dec 03.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Proliferation*/genetics
Neoplastic Stem Cells/*metabolism
Octamer Transcription Factor-3/*genetics
Thyroid Neoplasms/*pathology
Ubiquitin-Protein Ligases/*genetics
Cell Line, Tumor ; Cell Survival/genetics ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Humans ; Male ; Neoplastic Stem Cells/pathology ; Octamer Transcription Factor-3/metabolism ; Protein Stability ; Thyroid Neoplasms/genetics ; Thyroid Neoplasms/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination
Czasopismo naukowe
Tytuł :
TAp63 and ΔNp63 (p40) in prostate adenocarcinomas: ΔNp63 associates with a basal-like cancer stem cell population but not with metastasis.
Autorzy :
Galoczova M; Research Centre for Applied Molecular Oncology (RECAMO), Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic.
Nenutil R; Research Centre for Applied Molecular Oncology (RECAMO), Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic.
Pokorna Z; Research Centre for Applied Molecular Oncology (RECAMO), Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic.
Vojtesek B; Research Centre for Applied Molecular Oncology (RECAMO), Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic.
Coates PJ; Research Centre for Applied Molecular Oncology (RECAMO), Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic. .
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Źródło :
Virchows Archiv : an international journal of pathology [Virchows Arch] 2021 Apr; Vol. 478 (4), pp. 627-636. Date of Electronic Publication: 2020 Oct 10.
Typ publikacji :
Journal Article
MeSH Terms :
Adenocarcinoma/*secondary
Biomarkers, Tumor/*metabolism
Bone Neoplasms/*secondary
Neoplastic Stem Cells/*metabolism
Prostatic Neoplasms/*pathology
Transcription Factors/*metabolism
Tumor Suppressor Proteins/*metabolism
Adenocarcinoma/metabolism ; Adult ; Aged ; Aged, 80 and over ; Bone Neoplasms/metabolism ; Case-Control Studies ; Humans ; Male ; Middle Aged ; Neoplastic Stem Cells/pathology ; Phenotype ; Prostatic Neoplasms/metabolism ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Exosome-mediated delivery of functionally active miRNA-375-3p mimic regulate epithelial mesenchymal transition (EMT) of colon cancer cells.
Autorzy :
Rezaei R; Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Baghaei K; Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: .
Amani D; Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: .
Piccin A; Haematology Dept, Our Lady's Children's Hospital, Dublin, Ireland; Dept of Internal Medicine V, University of Innsbruck, Innsbruck, Austria.
Hashemi SM; Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Asadzadeh Aghdaei H; Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Zali MR; Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
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Źródło :
Life sciences [Life Sci] 2021 Mar 15; Vol. 269, pp. 119035. Date of Electronic Publication: 2021 Jan 13.
Typ publikacji :
Journal Article
MeSH Terms :
Epithelial-Mesenchymal Transition*
Gene Expression Regulation, Neoplastic*
Biomarkers, Tumor/*genetics
Colonic Neoplasms/*pathology
Exosomes/*genetics
MicroRNAs/*genetics
Neoplastic Stem Cells/*pathology
Apoptosis ; Biomarkers, Tumor/metabolism ; Biomimetics ; Cell Movement ; Cell Proliferation ; Colonic Neoplasms/genetics ; Colonic Neoplasms/metabolism ; Humans ; MicroRNAs/metabolism ; Neoplasm Invasiveness ; Neoplastic Stem Cells/metabolism ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
470 nm LED Irradiation Inhibits the Invasiveness of CD133-positive Human Colorectal Cancer Stem Cells by Suppressing the Cyclooxygenase-2/prostaglandin E2 Pathway.
Autorzy :
Mo S; Medical Laser Research Center, Dankook University, Cheonan, Republic of Korea.; Center for Bio-Medical Engineering Core Facility, Dankook University, Cheonan, Republic of Korea.
Ku HJ; Department of Medicine, Graduate School of Medical Science, Dankook University, Cheonan, Republic of Korea.
Choi SH; Center for Bio-Medical Engineering Core Facility, Dankook University, Cheonan, Republic of Korea.
Jeong HJ; Department of Medicine, Graduate School of Medical Science, Dankook University, Cheonan, Republic of Korea.
Park DG; Department of Surgery, College of Medicine, Dankook University, Cheonan, Republic of Korea.
Oh MH; Department of Nanobiomedical Science, Dankook University, Cheonan, Republic of Korea.
Ahn JC; Medical Laser Research Center, Dankook University, Cheonan, Republic of Korea; .; Center for Bio-Medical Engineering Core Facility, Dankook University, Cheonan, Republic of Korea.; Department of Medicine, Graduate School of Medical Science, Dankook University, Cheonan, Republic of Korea.; Photomedicine Research Center, Dankook University, Cheonan, Republic of Korea.
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Źródło :
Anticancer research [Anticancer Res] 2021 Mar; Vol. 41 (3), pp. 1407-1420.
Typ publikacji :
Journal Article
MeSH Terms :
Lasers, Semiconductor*
AC133 Antigen/*metabolism
Cyclooxygenase 2/*metabolism
Dinoprostone/*metabolism
Neoplastic Stem Cells/*radiation effects
Signal Transduction/*radiation effects
AC133 Antigen/genetics ; Cell Proliferation/genetics ; Cell Proliferation/radiation effects ; Cell Survival/genetics ; Cell Survival/radiation effects ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Cyclooxygenase 2/genetics ; Down-Regulation/radiation effects ; Gene Expression Regulation, Neoplastic/radiation effects ; Humans ; Matrix Metalloproteinase 2/genetics ; Matrix Metalloproteinase 2/metabolism ; Matrix Metalloproteinase 9/genetics ; Matrix Metalloproteinase 9/metabolism ; Neoplasm Invasiveness ; Neoplastic Stem Cells/metabolism ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
MCM10 compensates for Myc-induced DNA replication stress in breast cancer stem-like cells.
Autorzy :
Murayama T; Division of Molecular Therapy, Institute of Medical Science, The University of Tokyo, Minato-ku, Japan.; Division of Cancer Cell Biology, Cancer Research Institute, Kanazawa University, Kanazawa City, Japan.
Takeuchi Y; Division of Cancer Cell Biology, Cancer Research Institute, Kanazawa University, Kanazawa City, Japan.
Yamawaki K; Division of Cancer Differentiation, National Cancer Center Research Institute, Chuo-ku, Japan.; Department of Obstetrics and Gynecology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Natsume T; Department of Chromosome Science, National Institute of Genetics, Research Organization of Information and Systems (ROIS), Mishima City, Japan.; Department of Genetics, SOKENDAI, Mishima City, Japan.
Li M; Division of Cancer Cell Biology, Cancer Research Institute, Kanazawa University, Kanazawa City, Japan.
Marcela RN; Division of Cancer Cell Biology, Cancer Research Institute, Kanazawa University, Kanazawa City, Japan.
Nishimura T; Division of Cancer Cell Biology, Cancer Research Institute, Kanazawa University, Kanazawa City, Japan.
Kogure Y; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Science, The University of Tokyo, Kashiwa City, Japan.
Nakata A; Division of Cancer Cell Biology, Cancer Research Institute, Kanazawa University, Kanazawa City, Japan.; Department of Pediatrics, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Tominaga K; Division of Molecular Therapy, Institute of Medical Science, The University of Tokyo, Minato-ku, Japan.; Division of Cancer Cell Biology, Cancer Research Institute, Kanazawa University, Kanazawa City, Japan.; Division of Cancer Differentiation, National Cancer Center Research Institute, Chuo-ku, Japan.
Sasahara A; Division of Molecular Therapy, Institute of Medical Science, The University of Tokyo, Minato-ku, Japan.; Department of Breast & Endocrine Surgery, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan.
Yano M; Department of Surgery, Minamimachida Hospital, Machida City, Japan.
Ishikawa S; Department of Gastroenterological Surgery, Kanazawa University, Kanazawa City, Japan.
Ohta T; Department of Gastroenterological Surgery, Kanazawa University, Kanazawa City, Japan.
Ikeda K; Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Hidaka City, Japan.
Horie-Inoue K; Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Hidaka City, Japan.
Inoue S; Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Hidaka City, Japan.
Seki M; Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa City, Japan.
Suzuki Y; Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa City, Japan.
Sugano S; Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa City, Japan.
Enomoto T; Department of Obstetrics and Gynecology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Tanabe M; Department of Breast & Endocrine Surgery, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan.
Tada KI; Department of Pediatrics, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Kanemaki MT; Department of Chromosome Science, National Institute of Genetics, Research Organization of Information and Systems (ROIS), Mishima City, Japan.; Department of Genetics, SOKENDAI, Mishima City, Japan.
Okamoto K; Division of Cancer Differentiation, National Cancer Center Research Institute, Chuo-ku, Japan.
Tojo A; Division of Molecular Therapy, Institute of Medical Science, The University of Tokyo, Minato-ku, Japan.
Gotoh N; Division of Molecular Therapy, Institute of Medical Science, The University of Tokyo, Minato-ku, Japan.; Division of Cancer Cell Biology, Cancer Research Institute, Kanazawa University, Kanazawa City, Japan.
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Źródło :
Cancer science [Cancer Sci] 2021 Mar; Vol. 112 (3), pp. 1209-1224. Date of Electronic Publication: 2021 Jan 22.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms/*genetics
Minichromosome Maintenance Proteins/*metabolism
Neoplasm Recurrence, Local/*genetics
Neoplastic Stem Cells/*pathology
Proto-Oncogene Proteins c-myc/*metabolism
Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Breast/pathology ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; DNA Damage/drug effects ; DNA Replication/drug effects ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/genetics ; Female ; Humans ; Minichromosome Maintenance Proteins/genetics ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/prevention & control ; Neoplastic Stem Cells/drug effects ; Primary Cell Culture ; Proto-Oncogene Proteins c-myc/antagonists & inhibitors ; Spheroids, Cellular ; Tumor Cells, Cultured ; Up-Regulation
Czasopismo naukowe
Tytuł :
miR-98-5p inhibits gastric cancer cell stemness and chemoresistance by targeting branched-chain aminotransferases 1.
Autorzy :
Zhan P; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, PR China.
Shu X; Beijing Research Institute of Orthopaedics and Traumatology, Beijing JiShuiTan Hospital, Beijing 100035, PR China.
Chen M; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, PR China.
Sun L; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, PR China.
Yu L; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, PR China.
Liu J; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, PR China.
Sun L; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, PR China.
Yang Z; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, PR China.
Ran Y; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, PR China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jul 01; Vol. 276, pp. 119405. Date of Electronic Publication: 2021 Mar 31.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Neoplasm*
Gene Expression Regulation, Neoplastic*
Biomarkers, Tumor/*metabolism
MicroRNAs/*genetics
Neoplastic Stem Cells/*drug effects
Stomach Neoplasms/*drug therapy
Transaminases/*antagonists & inhibitors
Animals ; Antineoplastic Agents/pharmacology ; Apoptosis ; Biomarkers, Tumor/genetics ; Cell Movement ; Cell Proliferation ; Cisplatin/pharmacology ; Humans ; Hyaluronan Receptors/metabolism ; Male ; Mice ; Mice, Nude ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Prognosis ; Stomach Neoplasms/genetics ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/pathology ; Transaminases/genetics ; Transaminases/metabolism ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Synergistic Roles of Curcumin in Sensitising the Cisplatin Effect on a Cancer Stem Cell-Like Population Derived from Non-Small Cell Lung Cancer Cell Lines.
Autorzy :
Abdul Satar N; Lung Stem Cell and Gene Therapy Group, Regenerative Medicine Cluster, Advanced Medical and Dental Institute (IPPT), Universiti Sains Malaysia, , Penang 13200, Malaysia.
Ismail MN; Analytical Biochemistry Research Centre (ABrC), Universiti Sains Malaysia, Penang 11800, Malaysia.
Yahaya BH; Lung Stem Cell and Gene Therapy Group, Regenerative Medicine Cluster, Advanced Medical and Dental Institute (IPPT), Universiti Sains Malaysia, , Penang 13200, Malaysia.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Feb 18; Vol. 26 (4). Date of Electronic Publication: 2021 Feb 18.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Non-Small-Cell Lung/*pathology
Cisplatin/*pharmacology
Curcumin/*pharmacology
Lung Neoplasms/*pathology
Neoplastic Stem Cells/*pathology
Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Self Renewal/drug effects ; Cisplatin/therapeutic use ; Curcumin/therapeutic use ; Drug Synergism ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Spheroids, Cellular/drug effects ; Spheroids, Cellular/metabolism
Czasopismo naukowe
Tytuł :
LIGHT/LTβR signaling regulates self-renewal and differentiation of hematopoietic and leukemia stem cells.
Autorzy :
Höpner SS; Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, University of Bern, Bern, Switzerland.
Raykova A; Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, University of Bern, Bern, Switzerland.
Radpour R; Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, University of Bern, Bern, Switzerland.
Amrein MA; Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, University of Bern, Bern, Switzerland.
Koller D; Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, University of Bern, Bern, Switzerland.
Baerlocher GM; Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Riether C; Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, University of Bern, Bern, Switzerland.
Ochsenbein AF; Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. .; Department for BioMedical Research, University of Bern, Bern, Switzerland. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 16; Vol. 12 (1), pp. 1065. Date of Electronic Publication: 2021 Feb 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Differentiation*/drug effects
Cell Self Renewal*/drug effects
Cell Self Renewal*/genetics
Hematopoietic Stem Cells/*metabolism
Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*pathology
Lymphotoxin beta Receptor/*metabolism
Neoplastic Stem Cells/*pathology
Tumor Necrosis Factor Ligand Superfamily Member 14/*metabolism
Animals ; Antigens, CD34/metabolism ; Cell Cycle/drug effects ; Cell Cycle/genetics ; Cell Proliferation/drug effects ; DNA Damage ; Fluorouracil/pharmacology ; Gene Expression Regulation, Leukemic/drug effects ; Hematopoietic Stem Cells/drug effects ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Mice, Inbred C57BL ; Mice, Knockout ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Beyond regulations at DNA levels: A review of epigenetic therapeutics targeting cancer stem cells.
Autorzy :
Zhang S; State Key Laboratory of Oral Disease, National Clinical Research Center for Oral Disease, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Sichuan Province, Chengdu, China.
Gong Y; State Key Laboratory of Oral Disease, National Clinical Research Center for Oral Disease, Department of Temporomandibular Joint, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan Province, China.; State Key Laboratory of Oral Disease, National Clinical Research Center for Oral Disease, Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan Province, China.
Li C; State Key Laboratory of Oral Disease, National Clinical Research Center for Oral Disease, Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan Province, China.
Yang W; State Key Laboratory of Oral Disease, National Clinical Research Center for Oral Disease, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Sichuan Province, Chengdu, China.
Li L; State Key Laboratory of Oral Disease, National Clinical Research Center for Oral Disease, Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan Province, China.
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Źródło :
Cell proliferation [Cell Prolif] 2021 Feb; Vol. 54 (2), pp. e12963. Date of Electronic Publication: 2020 Dec 13.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Epigenesis, Genetic*
Neoplastic Stem Cells/*metabolism
Antagomirs/metabolism ; Antagomirs/pharmacology ; Antagomirs/therapeutic use ; DNA (Cytosine-5-)-Methyltransferases/antagonists & inhibitors ; DNA (Cytosine-5-)-Methyltransferases/metabolism ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/therapeutic use ; Epithelial-Mesenchymal Transition ; Histone Deacetylase Inhibitors/pharmacology ; Histone Deacetylase Inhibitors/therapeutic use ; Humans ; MicroRNAs/antagonists & inhibitors ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Neoplasms/drug therapy ; Neoplasms/pathology ; Neoplastic Stem Cells/cytology ; Neoplastic Stem Cells/drug effects
Czasopismo naukowe
Tytuł :
Breast cancer stem cells: A review of their characteristics and the agents that affect them.
Autorzy :
Shan NL; Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, USA.
Shin Y; Yonsei University, College of Medicine, Seoul, Republic of Korea.
Yang G; Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, USA.
Furmanski P; Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, USA.; Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, USA.
Suh N; Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, USA.; Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, USA.
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Źródło :
Molecular carcinogenesis [Mol Carcinog] 2021 Feb; Vol. 60 (2), pp. 73-100. Date of Electronic Publication: 2021 Jan 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Breast Neoplasms/*genetics
Drug Resistance, Neoplasm/*genetics
Neoplastic Stem Cells/*metabolism
Signal Transduction/*genetics
Transcription Factors/*genetics
Antineoplastic Agents/therapeutic use ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Cell Self Renewal/genetics ; Drug Resistance, Neoplasm/drug effects ; Humans ; Molecular Targeted Therapy/methods ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/pathology ; Signal Transduction/drug effects ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Epithelial-to-mesenchymal Transition Heterogeneity of Circulating Tumor Cells and Their Correlation With MDSCs and Tregs in HER2-negative Metastatic Breast Cancer Patients.
Autorzy :
Papadaki MA; Laboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion, Greece.
Aggouraki D; Laboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion, Greece.
Vetsika EK; Laboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion, Greece.
Xenidis N; Department of Medical Oncology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.; Hellenic Oncology Research Group (HORG), Athens, Greece.
Kallergi G; Hellenic Oncology Research Group (HORG), Athens, Greece.; Department of Biology, University of Patras, Patras, Greece.
Kotsakis A; Hellenic Oncology Research Group (HORG), Athens, Greece.; Department of Medical Oncology, University Hospital of Larissa & Laboratory of Oncology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Georgoulias V; Hellenic Oncology Research Group (HORG), Athens, Greece; .; School of Medicine, University of Crete, Heraklion, Greece.
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Źródło :
Anticancer research [Anticancer Res] 2021 Feb; Vol. 41 (2), pp. 661-670.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Epithelial-Mesenchymal Transition*
Tumor Escape*
Breast Neoplasms/*immunology
Myeloid-Derived Suppressor Cells/*immunology
Neoplastic Cells, Circulating/*immunology
Neoplastic Stem Cells/*immunology
T-Lymphocytes, Regulatory/*immunology
Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/blood ; Breast Neoplasms/blood ; Breast Neoplasms/pathology ; Case-Control Studies ; Female ; Flow Cytometry ; Humans ; Immunophenotyping ; Middle Aged ; Myeloid-Derived Suppressor Cells/metabolism ; Neoplastic Cells, Circulating/metabolism ; Neoplastic Cells, Circulating/pathology ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Phenotype ; T-Lymphocytes, Regulatory/metabolism
Czasopismo naukowe
Tytuł :
Wnt/β‑catenin signaling: Causes and treatment targets of drug resistance in colorectal cancer (Review).
Autorzy :
Zhu GX; Department of Gastroenterology and Hepatology, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Gao D; Department of Pathogen Biology and Immunology, Medical College of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Shao ZZ; Department of Gastroenterology and Hepatology, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Chen L; Department of Gastroenterology and Hepatology, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Ding WJ; Department of Gastroenterology and Hepatology, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Yu QF; Department of Gastroenterology and Hepatology, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2021 Feb; Vol. 23 (2). Date of Electronic Publication: 2020 Dec 10.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Colorectal Neoplasms*/drug therapy
Colorectal Neoplasms*/genetics
Colorectal Neoplasms*/metabolism
Colorectal Neoplasms*/pathology
Drug Delivery Systems*
Drug Resistance, Neoplasm*/drug effects
Drug Resistance, Neoplasm*/genetics
Neoplastic Stem Cells*/metabolism
Neoplastic Stem Cells*/pathology
Wnt Signaling Pathway*/drug effects
Wnt Signaling Pathway*/genetics
Animals ; Humans ; Neoplasm Metastasis
Czasopismo naukowe
Tytuł :
HPV-induced Nurr1 promotes cancer aggressiveness, self-renewal, and radioresistance via ERK and AKT signaling in cervical cancer.
Autorzy :
Wan PK; Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region of China.
Leung TH; Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region of China.
Siu MK; Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region of China.
Mo XT; Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region of China.
Tang HW; Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region of China.
Chan KK; Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region of China.
Cheung AN; Department of Pathology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region of China.
Ngan HY; Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region of China. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2021 Jan 28; Vol. 497, pp. 14-27. Date of Electronic Publication: 2020 Sep 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Radiation Tolerance*
Biomarkers, Tumor/*metabolism
Neoplastic Stem Cells/*pathology
Nuclear Receptor Subfamily 4, Group A, Member 2/*metabolism
Oncogene Proteins, Viral/*metabolism
Uterine Cervical Neoplasms/*pathology
Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Cell Proliferation ; Female ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Mitogen-Activated Protein Kinase 1/genetics ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/genetics ; Mitogen-Activated Protein Kinase 3/metabolism ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/radiation effects ; Nuclear Receptor Subfamily 4, Group A, Member 2/genetics ; Oncogene Proteins, Viral/genetics ; Papillomaviridae/physiology ; Papillomavirus Infections/complications ; Papillomavirus Infections/metabolism ; Papillomavirus Infections/virology ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; Tumor Cells, Cultured ; Uterine Cervical Neoplasms/metabolism ; Uterine Cervical Neoplasms/radiotherapy ; Uterine Cervical Neoplasms/virology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
HER2 overexpression triggers the IL-8 to promote arsenic-induced EMT and stem cell-like phenotypes in human bladder epithelial cells.
Autorzy :
Zhou Q; Department of Environmental and Occupational Health, Liaoning Provincial Key Laboratory of Arsenic Biological Effect and Poisoning, School of Public Health, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang 110122, Liaoning, PR China. Electronic address: .
Jin P; Department of Environmental and Occupational Health, Liaoning Provincial Key Laboratory of Arsenic Biological Effect and Poisoning, School of Public Health, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang 110122, Liaoning, PR China. Electronic address: .
Liu J; Department of Environmental and Occupational Health, Liaoning Provincial Key Laboratory of Arsenic Biological Effect and Poisoning, School of Public Health, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang 110122, Liaoning, PR China. Electronic address: .
Li S; Department of Environmental and Occupational Health, Liaoning Provincial Key Laboratory of Arsenic Biological Effect and Poisoning, School of Public Health, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang 110122, Liaoning, PR China. Electronic address: .
Liu W; Department of Environmental and Occupational Health, Liaoning Provincial Key Laboratory of Arsenic Biological Effect and Poisoning, School of Public Health, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang 110122, Liaoning, PR China. Electronic address: .
Xi S; Department of Environmental and Occupational Health, Liaoning Provincial Key Laboratory of Arsenic Biological Effect and Poisoning, School of Public Health, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang 110122, Liaoning, PR China. Electronic address: .
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2021 Jan 15; Vol. 208, pp. 111693. Date of Electronic Publication: 2020 Dec 04.
Typ publikacji :
Journal Article
MeSH Terms :
Arsenic/*toxicity
Epithelial Cells/*drug effects
Epithelial-Mesenchymal Transition/*drug effects
Interleukin-8/*metabolism
Neoplastic Stem Cells/*drug effects
Receptor, ErbB-2/*genetics
Urinary Bladder/*metabolism
Arsenic/metabolism ; Cell Line ; Cell Movement/drug effects ; Cell Movement/immunology ; Cell Survival/drug effects ; Epithelial Cells/immunology ; Epithelial Cells/metabolism ; Epithelial-Mesenchymal Transition/immunology ; Humans ; Hyaluronan Receptors/genetics ; Neoplastic Stem Cells/immunology ; Neoplastic Stem Cells/metabolism ; Phenotype ; Phosphatidylinositol 3-Kinases/metabolism ; Signal Transduction/drug effects ; Urinary Bladder/cytology
Czasopismo naukowe
Tytuł :
Patient-derived glioblastoma stem cells transfer mitochondria through tunneling nanotubes in tumor organoids.
Autorzy :
Pinto G; Unité de Trafic Membranaire et Pathogenèse, Institut Pasteur, UMR3691 CNRS, 28 rue du Docteur Roux, F-75015 Paris, France.; Sorbonne Université, ED394 - Physiologie, Physiopathologie et Thérapeutique, F-75005 Paris, France.
Saenz-de-Santa-Maria I; Unité de Trafic Membranaire et Pathogenèse, Institut Pasteur, UMR3691 CNRS, 28 rue du Docteur Roux, F-75015 Paris, France.
Chastagner P; Unité de Trafic Membranaire et Pathogenèse, Institut Pasteur, UMR3691 CNRS, 28 rue du Docteur Roux, F-75015 Paris, France.
Perthame E; Hub de Bioinformatique et Biostatistique - Département Biologie Computationnelle, Institut Pasteur, USR 3756 CNRS, F-75015 Paris, France.
Delmas C; Cancer Research Center of Toulouse (CRCT), Institut National de la Santé et de la Recherche Médicale (INSERM), UMR 1037, Institut Claudius Regaud, Université Toulouse III Paul Sabatier, Toulouse F-31000, France.
Toulas C; Cancer Research Center of Toulouse (CRCT), Institut National de la Santé et de la Recherche Médicale (INSERM), UMR 1037, Institut Claudius Regaud, Université Toulouse III Paul Sabatier, Toulouse F-31000, France.
Moyal-Jonathan-Cohen E; Cancer Research Center of Toulouse (CRCT), Institut National de la Santé et de la Recherche Médicale (INSERM), UMR 1037, Institut Claudius Regaud, Université Toulouse III Paul Sabatier, Toulouse F-31000, France.
Brou C; Unité de Trafic Membranaire et Pathogenèse, Institut Pasteur, UMR3691 CNRS, 28 rue du Docteur Roux, F-75015 Paris, France.
Zurzolo C; Unité de Trafic Membranaire et Pathogenèse, Institut Pasteur, UMR3691 CNRS, 28 rue du Docteur Roux, F-75015 Paris, France.
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Źródło :
The Biochemical journal [Biochem J] 2021 Jan 15; Vol. 478 (1), pp. 21-39.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Communication*
Brain Neoplasms/*metabolism
Cell Surface Extensions/*metabolism
Glioblastoma/*metabolism
Mitochondria/*metabolism
Neoplastic Stem Cells/*metabolism
Organoids/*metabolism
Brain Neoplasms/pathology ; Cell Line, Tumor ; Cell Surface Extensions/pathology ; Cells, Cultured ; Disease Progression ; GAP-43 Protein/metabolism ; Glioblastoma/pathology ; Humans ; Mitochondria/pathology ; Neoplastic Stem Cells/pathology ; Neoplastic Stem Cells/radiation effects ; Organoids/pathology ; Radiation ; Recurrence ; Time-Lapse Imaging
Czasopismo naukowe

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