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Wyszukujesz frazę ""Neoplastic Stem Cells"" wg kryterium: Temat


Tytuł :
Therapeutic Strategies for Targeting Ovarian Cancer Stem Cells.
Autorzy :
Yang W; Convergence Stem Cell Research Center, Pusan National University, Yangsan 50612, Gyeongsangnam-do, Korea.
Kim D; Department of Physiology, School of Medicine, Pusan National University, Yangsan 50612, Gyeongsangnam-do, Korea.
Kim DK; Department of Physiology, School of Medicine, Pusan National University, Yangsan 50612, Gyeongsangnam-do, Korea.
Choi KU; Department of Pathology, Pusan National University Hospital, Busan 49241, Korea.
Suh DS; Department of Obstetrics and Gynecology, Pusan National University Hospital, Busan 49241, Korea.
Kim JH; Department of Physiology, School of Medicine, Pusan National University, Yangsan 50612, Gyeongsangnam-do, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 11; Vol. 22 (10). Date of Electronic Publication: 2021 May 11.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Molecular Targeted Therapy*
Antineoplastic Agents/*therapeutic use
Biomarkers, Tumor/*antagonists & inhibitors
Neoplastic Stem Cells/*drug effects
Ovarian Neoplasms/*drug therapy
Animals ; Biomarkers, Tumor/metabolism ; Female ; Humans ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Ovarian Neoplasms/metabolism ; Ovarian Neoplasms/pathology ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Dietary Phytochemicals as a Potential Source for Targeting Cancer Stem Cells.
Autorzy :
Manogaran P; Department of Biotechnology, Bharathiar University, Coimbatore, Tamilnadu, India.
Umapathy D; Department of Biochemistry, Bharathidasan University, Tiruchirappalli, Tamilnadu, India.
Karthikeyan M; Department of Biochemistry, Bharathidasan University, Tiruchirappalli, Tamilnadu, India.
Venkatachalam K; Department of Pharmacology & Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
Singaravelu A; Department of PG and Research Department of Biochemistry, Sacred Heart College (Autonomous), Tirupattur, Tamilnadu, India.
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Źródło :
Cancer investigation [Cancer Invest] 2021 Apr; Vol. 39 (4), pp. 349-368. Date of Electronic Publication: 2021 Mar 10.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Diet*/adverse effects
Antineoplastic Agents, Phytogenic/*therapeutic use
Neoplasms/*drug therapy
Neoplastic Stem Cells/*drug effects
Phytochemicals/*therapeutic use
Animals ; Antineoplastic Agents, Phytogenic/adverse effects ; Drug Resistance, Neoplasm ; Humans ; Neoplasms/metabolism ; Neoplasms/pathology ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Phytochemicals/adverse effects ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Dichloroacetate attenuates the stemness of colorectal cancer cells via trigerring ferroptosis through sequestering iron in lysosomes.
Autorzy :
Sun J; Department of Gastroenterology, The Affiliated Suzhou Science and Technology Town Hospital of Nanjing Medical University, Suzhou, Jiangsu, China.
Cheng X; Department of Gastroenterology, The Affiliated Suzhou Science and Technology Town Hospital of Nanjing Medical University, Suzhou, Jiangsu, China.
Pan S; Department of Gastroenterology, The Affiliated Suzhou Science and Technology Town Hospital of Nanjing Medical University, Suzhou, Jiangsu, China.
Wang L; Department of Gastroenterology, The Affiliated Suzhou Science and Technology Town Hospital of Nanjing Medical University, Suzhou, Jiangsu, China.
Dou W; Department of Gastroenterology, The Affiliated Suzhou Science and Technology Town Hospital of Nanjing Medical University, Suzhou, Jiangsu, China.
Liu J; Department of Gastroenterology, The Affiliated Suzhou Science and Technology Town Hospital of Nanjing Medical University, Suzhou, Jiangsu, China.
Shi X; Department of Gastroenterology, The Affiliated Suzhou Science and Technology Town Hospital of Nanjing Medical University, Suzhou, Jiangsu, China.
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Źródło :
Environmental toxicology [Environ Toxicol] 2021 Apr; Vol. 36 (4), pp. 520-529. Date of Electronic Publication: 2020 Nov 09.
Typ publikacji :
Journal Article
MeSH Terms :
Colorectal Neoplasms/*pathology
Dichloroacetic Acid/*pharmacology
Ferroptosis/*drug effects
Iron/*metabolism
Lysosomes/*drug effects
Neoplastic Stem Cells/*drug effects
Sequestering Agents/*pharmacology
Cell Movement/drug effects ; Cell Survival/drug effects ; Colorectal Neoplasms/metabolism ; Dose-Response Relationship, Drug ; HCT116 Cells ; HT29 Cells ; Humans ; Lysosomes/metabolism ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology
Czasopismo naukowe
Tytuł :
Stem-like tumor cells and proinflammatory cytokines in the ascitic fluid of ovarian cancer patients.
Autorzy :
Gening SO; Federal State Budgetary Educational Institution of Higher Education Ulyanovsk State University.
Abakumova TV; Federal State Budgetary Educational Institution of Higher Education Ulyanovsk State University.
Antoneeva II; Federal State Budgetary Educational Institution of Higher Education Ulyanovsk State University; Federal Healthcare Institution Regional Clinical Oncology Center.
Rizvanov AA; Federal State Autonomous Educational Institution of Higher Education «Kazan (Volga Regional) Federal University».
Gening TP; Federal State Budgetary Educational Institution of Higher Education Ulyanovsk State University.
Gafurbaeva DU; Federal State Autonomous Educational Institution of Higher Education «Kazan (Volga Regional) Federal University».
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Transliterated Title :
Стволово-подобные опухолевые клетки и провоспалительные цитокины в асцитической жидкости пациенток с раком яичников.
Źródło :
Klinicheskaia laboratornaia diagnostika [Klin Lab Diagn] 2021 May 23; Vol. 66 (5), pp. 297-303.
Typ publikacji :
Journal Article
MeSH Terms :
Ascitic Fluid*
Cytokines*
Neoplastic Stem Cells*
Ovarian Neoplasms*
Female ; Flow Cytometry ; Humans ; Prospective Studies
Czasopismo naukowe
Tytuł :
Tumor Dormancy: Implications for Invasion and Metastasis.
Autorzy :
Gomatou G; Oncology Unit, Third Department of Medicine, Sotiria General Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Syrigos N; Oncology Unit, Third Department of Medicine, Sotiria General Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Vathiotis IA; Oncology Unit, Third Department of Medicine, Sotiria General Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Kotteas EA; Oncology Unit, Third Department of Medicine, Sotiria General Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 04; Vol. 22 (9). Date of Electronic Publication: 2021 May 04.
Typ publikacji :
Journal Article; Review
MeSH Terms :
MicroRNAs/*genetics
Mitogen-Activated Protein Kinases/*genetics
Neoplasm Proteins/*genetics
Neoplasm Recurrence, Local/*genetics
Neoplasms/*genetics
Neoplastic Stem Cells/*metabolism
Animals ; Apoptosis/genetics ; Autophagy/genetics ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Humans ; Lymphatic Metastasis ; MicroRNAs/metabolism ; Mitogen-Activated Protein Kinases/metabolism ; Neoplasm Proteins/metabolism ; Neoplasm Recurrence, Local/metabolism ; Neoplasm Recurrence, Local/pathology ; Neoplasms/metabolism ; Neoplasms/pathology ; Neoplastic Stem Cells/pathology ; Signal Transduction ; Tumor Microenvironment/genetics
Czasopismo naukowe
Tytuł :
New routes to eradicating chronic myelogenous leukemia stem cells by targeting metabolism.
Autorzy :
Naka K; Department of Stem Cell Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan. .
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Źródło :
International journal of hematology [Int J Hematol] 2021 May; Vol. 113 (5), pp. 648-655. Date of Electronic Publication: 2021 Mar 05.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Agents/*pharmacology
Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*drug therapy
Metabolic Networks and Pathways/*drug effects
Neoplastic Stem Cells/*drug effects
Amino Acids/metabolism ; Animals ; Antineoplastic Agents/therapeutic use ; Blast Crisis/drug therapy ; Blast Crisis/metabolism ; Blast Crisis/pathology ; Glucose/metabolism ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/metabolism ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology ; Lipid Metabolism/drug effects ; Molecular Targeted Therapy ; Neoplastic Stem Cells/metabolism ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use
Czasopismo naukowe
Tytuł :
Isolation and Characterization of Human Colon Adenocarcinoma Stem-Like Cells Based on the Endogenous Expression of the Stem Markers.
Autorzy :
Koshkin SA; Institute of Cytology of the Russian Academy of Science, 194064 St-Petersburg, Russia.; Department of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, 1015 Walnut Street, Ste. 1024, Philadelphia, PA 19107, USA.
Anatskaya OV; Institute of Cytology of the Russian Academy of Science, 194064 St-Petersburg, Russia.
Vinogradov AE; Institute of Cytology of the Russian Academy of Science, 194064 St-Petersburg, Russia.
Uversky VN; Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
Dayhoff GW 2nd; Department of Chemistry, College of Art and Sciences, University of South Florida, Tampa, FL 33620, USA.
Bystriakova MA; Institute of Cytology of the Russian Academy of Science, 194064 St-Petersburg, Russia.
Pospelov VA; Institute of Cytology of the Russian Academy of Science, 194064 St-Petersburg, Russia.
Tolkunova EN; Institute of Cytology of the Russian Academy of Science, 194064 St-Petersburg, Russia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 28; Vol. 22 (9). Date of Electronic Publication: 2021 Apr 28.
Typ publikacji :
Journal Article
MeSH Terms :
Adenocarcinoma/*pathology
Colonic Neoplasms/*pathology
Neoplastic Stem Cells/*metabolism
Adenocarcinoma/genetics ; Adult ; Biomarkers, Tumor/isolation & purification ; Cell Culture Techniques/methods ; Cell Cycle ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Colonic Neoplasms/genetics ; Female ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Male ; Middle Aged ; Neoplastic Stem Cells/pathology ; Octamer Transcription Factor-3/genetics ; Octamer Transcription Factor-3/metabolism ; Primary Cell Culture ; SOXB1 Transcription Factors/genetics ; SOXB1 Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Pancreatic cancer stem cells may define tumor stroma characteristics and recurrence patterns in pancreatic ductal adenocarcinoma.
Autorzy :
Askan G; Memorial Sloan Kettering Cancer Center, 300 East 66th street, office 1021, New York, NY, 10065, USA.
Sahin IH; H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA.
Chou JF; Memorial Sloan Kettering Cancer Center, 300 East 66th street, office 1021, New York, NY, 10065, USA.
Yavas A; Memorial Sloan Kettering Cancer Center, 300 East 66th street, office 1021, New York, NY, 10065, USA.
Capanu M; Memorial Sloan Kettering Cancer Center, 300 East 66th street, office 1021, New York, NY, 10065, USA.
Iacobuzio-Donahue CA; Memorial Sloan Kettering Cancer Center, 300 East 66th street, office 1021, New York, NY, 10065, USA.; David M. Rubenstein Center for Pancreatic Cancer, New York, USA.
Basturk O; Memorial Sloan Kettering Cancer Center, 300 East 66th street, office 1021, New York, NY, 10065, USA.; David M. Rubenstein Center for Pancreatic Cancer, New York, USA.
O'Reilly EM; Memorial Sloan Kettering Cancer Center, 300 East 66th street, office 1021, New York, NY, 10065, USA. .; David M. Rubenstein Center for Pancreatic Cancer, New York, USA. .; Weill Cornell Medical College, New York, USA. .
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Źródło :
BMC cancer [BMC Cancer] 2021 Apr 09; Vol. 21 (1), pp. 385. Date of Electronic Publication: 2021 Apr 09.
Typ publikacji :
Journal Article
MeSH Terms :
Cancer-Associated Fibroblasts/*metabolism
Carcinoma, Pancreatic Ductal/*metabolism
Carcinoma, Pancreatic Ductal/*pathology
Neoplastic Stem Cells/*metabolism
Pancreatic Neoplasms/*metabolism
Pancreatic Neoplasms/*pathology
Stromal Cells/*metabolism
Biomarkers ; Cancer-Associated Fibroblasts/pathology ; Carcinoma, Pancreatic Ductal/mortality ; Carcinoma, Pancreatic Ductal/therapy ; Combined Modality Therapy ; Female ; Humans ; Immunohistochemistry ; Male ; Neoplasm Grading ; Neoplasm Metastasis ; Neoplasm Staging ; Neoplastic Stem Cells/pathology ; Pancreatic Neoplasms/mortality ; Pancreatic Neoplasms/therapy ; Prognosis ; Recurrence ; Stromal Cells/pathology ; Treatment Outcome ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
MicroRNA Regulation of Breast Cancer Stemness.
Autorzy :
Humphries B; Center for Molecular Imaging, Department of Radiology, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA.
Wang Z; Division of Cancer Biology, Department of Medicine, MetroHealth Medical Center, Case Western Reserve University School of Medicine, 2500 MetroHealth Drive, Cleveland, OH 44109, USA.
Yang C; Division of Cancer Biology, Department of Medicine, MetroHealth Medical Center, Case Western Reserve University School of Medicine, 2500 MetroHealth Drive, Cleveland, OH 44109, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 04; Vol. 22 (7). Date of Electronic Publication: 2021 Apr 04.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Signal Transduction*
Breast Neoplasms/*metabolism
MicroRNAs/*biosynthesis
Neoplastic Stem Cells/*metabolism
RNA, Neoplasm/*biosynthesis
Breast Neoplasms/pathology ; Female ; Humans ; Neoplastic Stem Cells/pathology
Czasopismo naukowe
Tytuł :
Cell signaling pathways as molecular targets to eliminate AML stem cells.
Autorzy :
Rodrigues ACBDC; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador, Bahia, 40296-710, Brazil.
Costa RGA; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador, Bahia, 40296-710, Brazil.
Silva SLR; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador, Bahia, 40296-710, Brazil.
Dias IRSB; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador, Bahia, 40296-710, Brazil.
Dias RB; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador, Bahia, 40296-710, Brazil.
Bezerra DP; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador, Bahia, 40296-710, Brazil. Electronic address: .
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Źródło :
Critical reviews in oncology/hematology [Crit Rev Oncol Hematol] 2021 Apr; Vol. 160, pp. 103277. Date of Electronic Publication: 2021 Mar 11.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Leukemia, Myeloid, Acute*/drug therapy
Leukemia, Myeloid, Acute*/genetics
Neoplastic Stem Cells*/metabolism
Humans ; NF-kappa B/metabolism ; Phosphatidylinositol 3-Kinases ; Signal Transduction
Czasopismo naukowe
Tytuł :
Mitochondrial dynamics in cancer stem cells.
Autorzy :
Sessions DT; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia Health System, Charlottesville, VA, 22908, USA.
Kashatus DF; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia Health System, Charlottesville, VA, 22908, USA. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Apr; Vol. 78 (8), pp. 3803-3816. Date of Electronic Publication: 2021 Feb 13.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Mitochondrial Dynamics*
Mitochondria/*metabolism
Neoplasms/*metabolism
Neoplastic Stem Cells/*metabolism
Animals ; Epithelial-Mesenchymal Transition ; Humans ; Mitochondria/pathology ; Mitophagy ; Neoplasms/pathology ; Neoplastic Stem Cells/pathology ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
Carboxy terminus of HSP70-interacting protein (CHIP) attenuates the stemness of thyroid cancer cells through decreasing OCT4 protein stability.
Autorzy :
Xu Y; Department of the Health Management, Neurosurgery, Traditional Chinese Medicine, Nuclear Medicine, Ultrasonic Examination Room, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Xu G; Department of the Health Management, Neurosurgery, Traditional Chinese Medicine, Nuclear Medicine, Ultrasonic Examination Room, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Dang H; Department of the Health Management, Neurosurgery, Traditional Chinese Medicine, Nuclear Medicine, Ultrasonic Examination Room, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Qu W; Department of the Health Management, Neurosurgery, Traditional Chinese Medicine, Nuclear Medicine, Ultrasonic Examination Room, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Chang D; Department of the Health Management, Neurosurgery, Traditional Chinese Medicine, Nuclear Medicine, Ultrasonic Examination Room, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
He X; Department of the Health Management, Neurosurgery, Traditional Chinese Medicine, Nuclear Medicine, Ultrasonic Examination Room, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Li M; Department of the Health Management, Neurosurgery, Traditional Chinese Medicine, Nuclear Medicine, Ultrasonic Examination Room, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Wang Q; Department of the Health Management, Neurosurgery, Traditional Chinese Medicine, Nuclear Medicine, Ultrasonic Examination Room, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
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Źródło :
Environmental toxicology [Environ Toxicol] 2021 Apr; Vol. 36 (4), pp. 686-693. Date of Electronic Publication: 2020 Dec 03.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Proliferation*/genetics
Neoplastic Stem Cells/*metabolism
Octamer Transcription Factor-3/*genetics
Thyroid Neoplasms/*pathology
Ubiquitin-Protein Ligases/*genetics
Cell Line, Tumor ; Cell Survival/genetics ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Humans ; Male ; Neoplastic Stem Cells/pathology ; Octamer Transcription Factor-3/metabolism ; Protein Stability ; Thyroid Neoplasms/genetics ; Thyroid Neoplasms/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination
Czasopismo naukowe
Tytuł :
TAp63 and ΔNp63 (p40) in prostate adenocarcinomas: ΔNp63 associates with a basal-like cancer stem cell population but not with metastasis.
Autorzy :
Galoczova M; Research Centre for Applied Molecular Oncology (RECAMO), Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic.
Nenutil R; Research Centre for Applied Molecular Oncology (RECAMO), Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic.
Pokorna Z; Research Centre for Applied Molecular Oncology (RECAMO), Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic.
Vojtesek B; Research Centre for Applied Molecular Oncology (RECAMO), Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic.
Coates PJ; Research Centre for Applied Molecular Oncology (RECAMO), Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic. .
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Źródło :
Virchows Archiv : an international journal of pathology [Virchows Arch] 2021 Apr; Vol. 478 (4), pp. 627-636. Date of Electronic Publication: 2020 Oct 10.
Typ publikacji :
Journal Article
MeSH Terms :
Adenocarcinoma/*secondary
Biomarkers, Tumor/*metabolism
Bone Neoplasms/*secondary
Neoplastic Stem Cells/*metabolism
Prostatic Neoplasms/*pathology
Transcription Factors/*metabolism
Tumor Suppressor Proteins/*metabolism
Adenocarcinoma/metabolism ; Adult ; Aged ; Aged, 80 and over ; Bone Neoplasms/metabolism ; Case-Control Studies ; Humans ; Male ; Middle Aged ; Neoplastic Stem Cells/pathology ; Phenotype ; Prostatic Neoplasms/metabolism ; Retrospective Studies
Czasopismo naukowe
Tytuł :
miR-98-5p inhibits gastric cancer cell stemness and chemoresistance by targeting branched-chain aminotransferases 1.
Autorzy :
Zhan P; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, PR China.
Shu X; Beijing Research Institute of Orthopaedics and Traumatology, Beijing JiShuiTan Hospital, Beijing 100035, PR China.
Chen M; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, PR China.
Sun L; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, PR China.
Yu L; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, PR China.
Liu J; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, PR China.
Sun L; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, PR China.
Yang Z; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, PR China.
Ran Y; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, PR China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jul 01; Vol. 276, pp. 119405. Date of Electronic Publication: 2021 Mar 31.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Neoplasm*
Gene Expression Regulation, Neoplastic*
Biomarkers, Tumor/*metabolism
MicroRNAs/*genetics
Neoplastic Stem Cells/*drug effects
Stomach Neoplasms/*drug therapy
Transaminases/*antagonists & inhibitors
Animals ; Antineoplastic Agents/pharmacology ; Apoptosis ; Biomarkers, Tumor/genetics ; Cell Movement ; Cell Proliferation ; Cisplatin/pharmacology ; Humans ; Hyaluronan Receptors/metabolism ; Male ; Mice ; Mice, Nude ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Prognosis ; Stomach Neoplasms/genetics ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/pathology ; Transaminases/genetics ; Transaminases/metabolism ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Combining radiation to EGFR and Bcl-2 blockade: a new approach to target cancer stem cells in head and neck squamous cell carcinoma.
Autorzy :
Guy JB; Faculté de Médecine-Lyon-Sud, Université Lyon 1, 69921, Oullins, France. .; Laboratoire de Radiobiologie Cellulaire et Moléculaire, Faculté de Médecine Lyon Sud, CNRS UMR 5822 IP2I, 165 Chemin du Grand Revoyet, BP 12, 69921, Oullins Cedex, France. .; Département de Radiothérapie, Institut de Cancérologie de La Loire, Lucien Neuwirth, 42270, St Priest en Jarez, France. .
Espenel S; Faculté de Médecine-Lyon-Sud, Université Lyon 1, 69921, Oullins, France.; Laboratoire de Radiobiologie Cellulaire et Moléculaire, Faculté de Médecine Lyon Sud, CNRS UMR 5822 IP2I, 165 Chemin du Grand Revoyet, BP 12, 69921, Oullins Cedex, France.; Département de Radiothérapie, Institut de Cancérologie de La Loire, Lucien Neuwirth, 42270, St Priest en Jarez, France.
Louati S; Faculté de Médecine-Lyon-Sud, Université Lyon 1, 69921, Oullins, France.; Laboratoire de Radiobiologie Cellulaire et Moléculaire, Faculté de Médecine Lyon Sud, CNRS UMR 5822 IP2I, 165 Chemin du Grand Revoyet, BP 12, 69921, Oullins Cedex, France.; Département de Radiothérapie, Institut de Cancérologie de La Loire, Lucien Neuwirth, 42270, St Priest en Jarez, France.
Gauthier A; Faculté de Médecine-Lyon-Sud, Université Lyon 1, 69921, Oullins, France.; Laboratoire de Radiobiologie Cellulaire et Moléculaire, Faculté de Médecine Lyon Sud, CNRS UMR 5822 IP2I, 165 Chemin du Grand Revoyet, BP 12, 69921, Oullins Cedex, France.; Hospices Civils de Lyon, 69229, Lyon, France.
Garcia MA; Département de Santé Publique, Institut de Cancérologie de La Loire, Lucien Neuwirth, 42270, St Priest en Jarez, France.
Vial N; Département de Radiothérapie, Institut de Cancérologie de La Loire, Lucien Neuwirth, 42270, St Priest en Jarez, France.
Malésys C; Faculté de Médecine-Lyon-Sud, Université Lyon 1, 69921, Oullins, France.; Laboratoire de Radiobiologie Cellulaire et Moléculaire, Faculté de Médecine Lyon Sud, CNRS UMR 5822 IP2I, 165 Chemin du Grand Revoyet, BP 12, 69921, Oullins Cedex, France.
Ardail D; Faculté de Médecine-Lyon-Sud, Université Lyon 1, 69921, Oullins, France.; Laboratoire de Radiobiologie Cellulaire et Moléculaire, Faculté de Médecine Lyon Sud, CNRS UMR 5822 IP2I, 165 Chemin du Grand Revoyet, BP 12, 69921, Oullins Cedex, France.; Hospices Civils de Lyon, 69229, Lyon, France.
Alphonse G; Laboratoire de Radiobiologie Cellulaire et Moléculaire, Faculté de Médecine Lyon Sud, CNRS UMR 5822 IP2I, 165 Chemin du Grand Revoyet, BP 12, 69921, Oullins Cedex, France.; Hospices Civils de Lyon, 69229, Lyon, France.
Wozny AS; Faculté de Médecine-Lyon-Sud, Université Lyon 1, 69921, Oullins, France.; Laboratoire de Radiobiologie Cellulaire et Moléculaire, Faculté de Médecine Lyon Sud, CNRS UMR 5822 IP2I, 165 Chemin du Grand Revoyet, BP 12, 69921, Oullins Cedex, France.; Hospices Civils de Lyon, 69229, Lyon, France.
Rodriguez-Lafrasse C; Faculté de Médecine-Lyon-Sud, Université Lyon 1, 69921, Oullins, France.; Laboratoire de Radiobiologie Cellulaire et Moléculaire, Faculté de Médecine Lyon Sud, CNRS UMR 5822 IP2I, 165 Chemin du Grand Revoyet, BP 12, 69921, Oullins Cedex, France.; Hospices Civils de Lyon, 69229, Lyon, France.
Magné N; Laboratoire de Radiobiologie Cellulaire et Moléculaire, Faculté de Médecine Lyon Sud, CNRS UMR 5822 IP2I, 165 Chemin du Grand Revoyet, BP 12, 69921, Oullins Cedex, France.; Département de Radiothérapie, Institut de Cancérologie de La Loire, Lucien Neuwirth, 42270, St Priest en Jarez, France.
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Źródło :
Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2021 Jul; Vol. 147 (7), pp. 1905-1916. Date of Electronic Publication: 2021 Mar 31.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Chemoradiotherapy/*methods
Head and Neck Neoplasms/*therapy
Neoplastic Stem Cells/*pathology
Proto-Oncogene Proteins c-bcl-2/*antagonists & inhibitors
Squamous Cell Carcinoma of Head and Neck/*therapy
Animals ; Apoptosis ; Bridged Bicyclo Compounds, Heterocyclic/administration & dosage ; Cell Movement ; Cell Proliferation ; Cetuximab/administration & dosage ; ErbB Receptors/antagonists & inhibitors ; Female ; Gene Expression Regulation, Neoplastic ; Head and Neck Neoplasms/metabolism ; Head and Neck Neoplasms/pathology ; Humans ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/radiation effects ; Squamous Cell Carcinoma of Head and Neck/metabolism ; Squamous Cell Carcinoma of Head and Neck/pathology ; Sulfonamides/administration & dosage ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Glioblastoma cell line shows phenotypes of cancer stem cells in hypoxic microenvironment of spheroids.
Autorzy :
Ohnishi K; Department of Biol, Ibaraki Prefectural University of Health Sciences, Japan. Electronic address: .
Tani T; National Institute of Radiological Sciences Hospital, Japan.
Tojo N; Department of Biol, Ibaraki Prefectural University of Health Sciences, Japan.
Sagara JI; Department of Biochem, Ibaraki Prefectural University of Health Sciences, Japan.
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Mar 26; Vol. 546, pp. 150-154. Date of Electronic Publication: 2021 Feb 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Hypoxia*
Models, Biological*
Tumor Microenvironment*
Glioblastoma/*pathology
Neoplastic Stem Cells/*metabolism
Neoplastic Stem Cells/*pathology
Spheroids, Cellular/*metabolism
Spheroids, Cellular/*pathology
AC133 Antigen/metabolism ; Cell Culture Techniques ; Cell Line, Tumor ; Cell Movement ; Cell Survival/drug effects ; Cell Survival/radiation effects ; Flow Cytometry ; Genes, Reporter ; Humans ; Hydrogen-Ion Concentration ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Neoplastic Stem Cells/drug effects ; Phenotype ; Spheroids, Cellular/drug effects ; Spheroids, Cellular/radiation effects ; Temozolomide/pharmacology ; X-Rays
Czasopismo naukowe
Tytuł :
In Ovarian Cancer Multicellular Spheroids, Platelet Releasate Promotes Growth, Expansion of ALDH+ and CD133+ Cancer Stem Cells, and Protection against the Cytotoxic Effects of Cisplatin, Carboplatin and Paclitaxel.
Autorzy :
Casagrande N; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italy.
Borghese C; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italy.
Agostini F; Stem Cell Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081 Aviano, Italy.
Durante C; Stem Cell Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081 Aviano, Italy.
Mazzucato M; Stem Cell Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081 Aviano, Italy.
Colombatti A; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italy.
Aldinucci D; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 16; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 16.
Typ publikacji :
Journal Article
MeSH Terms :
AC133 Antigen/*metabolism
Aldehyde Dehydrogenase/*metabolism
Antineoplastic Agents/*pharmacology
Blood Platelets/*metabolism
Cytoprotection/*drug effects
Neoplastic Stem Cells/*pathology
Ovarian Neoplasms/*pathology
Spheroids, Cellular/*pathology
Apoptosis/drug effects ; Blood Platelets/drug effects ; Carboplatin/pharmacology ; Cell Death/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cisplatin/pharmacology ; Female ; Humans ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism ; Paclitaxel/pharmacology ; Spheroids, Cellular/drug effects
Czasopismo naukowe
Tytuł :
Berberine inhibits chemotherapy-exacerbated ovarian cancer stem cell-like characteristics and metastasis through GLI1.
Autorzy :
Zhao Y; Department of Pharmacology, Nanomedicine Engineering Laboratory of Jilin Province, College of Basic Medical Sciences, Jilin University, Changchun 130021, People's Republic of China.
Yang X; Department of Pharmacology, Nanomedicine Engineering Laboratory of Jilin Province, College of Basic Medical Sciences, Jilin University, Changchun 130021, People's Republic of China.
Zhao J; Department of Pharmacology, Nanomedicine Engineering Laboratory of Jilin Province, College of Basic Medical Sciences, Jilin University, Changchun 130021, People's Republic of China.
Gao M; Department of Pharmacology, Nanomedicine Engineering Laboratory of Jilin Province, College of Basic Medical Sciences, Jilin University, Changchun 130021, People's Republic of China.
Zhang M; Department of Pharmacology, Nanomedicine Engineering Laboratory of Jilin Province, College of Basic Medical Sciences, Jilin University, Changchun 130021, People's Republic of China.
Shi T; Department of Pharmacology, Nanomedicine Engineering Laboratory of Jilin Province, College of Basic Medical Sciences, Jilin University, Changchun 130021, People's Republic of China.
Zhang F; Department of Pharmacology, Nanomedicine Engineering Laboratory of Jilin Province, College of Basic Medical Sciences, Jilin University, Changchun 130021, People's Republic of China.
Zheng X; Department of Pharmacology, Nanomedicine Engineering Laboratory of Jilin Province, College of Basic Medical Sciences, Jilin University, Changchun 130021, People's Republic of China.
Pan Y; Department of Pharmacology, Nanomedicine Engineering Laboratory of Jilin Province, College of Basic Medical Sciences, Jilin University, Changchun 130021, People's Republic of China.
Shao D; Institutes of Life Sciences, School of Biomedical Sciences and Engineering and National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou International Campus, Guangzhou, Guangdong 510006, People's Republic of China.
Li J; Department of Pharmacology, Nanomedicine Engineering Laboratory of Jilin Province, College of Basic Medical Sciences, Jilin University, Changchun 130021, People's Republic of China.
He K; Department of Pharmacology, Nanomedicine Engineering Laboratory of Jilin Province, College of Basic Medical Sciences, Jilin University, Changchun 130021, People's Republic of China. Electronic address: .
Chen L; Department of Pharmacology, Nanomedicine Engineering Laboratory of Jilin Province, College of Basic Medical Sciences, Jilin University, Changchun 130021, People's Republic of China; School of Nursing, Jilin University, Changchun 130021, People's Republic of China. Electronic address: .
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2021 Mar 15; Vol. 895, pp. 173887. Date of Electronic Publication: 2021 Jan 20.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*toxicity
Berberine/*pharmacology
Carboplatin/*toxicity
Cell Movement/*drug effects
Etoposide/*toxicity
Neoplastic Stem Cells/*drug effects
Ovarian Neoplasms/*drug therapy
Zinc Finger Protein GLI1/*metabolism
Cell Line, Tumor ; Coculture Techniques ; Epithelial-Mesenchymal Transition/drug effects ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Neoplasm Metastasis ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/metabolism ; Ovarian Neoplasms/pathology ; Polycomb Repressive Complex 1/genetics ; Polycomb Repressive Complex 1/metabolism ; Signal Transduction ; Snail Family Transcription Factors/genetics ; Snail Family Transcription Factors/metabolism ; Vimentin/genetics ; Vimentin/metabolism ; Zinc Finger Protein GLI1/genetics
Czasopismo naukowe
Tytuł :
Stem cell-based therapy treating glioblastoma multiforme.
Autorzy :
Abadi B; Department of Pharmaceutics, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran; Student Research Committee, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.
Ahmadi-Zeidabadi M; Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Dini L; Department of Biology and Biotechnology 'Charles Darwin', Sapienza University of Rome, Rome, Italy; CNR Nanotec, Lecce, Italy.
Vergallo C; Department of Pharmacy, University of Chieti-Pescara 'G. d'Annunzio', Chieti, Italy. Electronic address: .
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Źródło :
Hematology/oncology and stem cell therapy [Hematol Oncol Stem Cell Ther] 2021 Mar; Vol. 14 (1), pp. 1-15. Date of Electronic Publication: 2020 Sep 16.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Blood-Brain Barrier*/metabolism
Blood-Brain Barrier*/pathology
Brain Neoplasms*/diagnosis
Brain Neoplasms*/metabolism
Brain Neoplasms*/pathology
Brain Neoplasms*/therapy
Cell- and Tissue-Based Therapy*
Glioblastoma*/diagnosis
Glioblastoma*/metabolism
Glioblastoma*/pathology
Glioblastoma*/therapy
Neoplastic Stem Cells*/metabolism
Neoplastic Stem Cells*/pathology
Humans ; Prognosis
Czasopismo naukowe
Tytuł :
IL-6 and IL-8, secreted by myofibroblasts in the tumor microenvironment, activate HES1 to expand the cancer stem cell population in early colorectal tumor.
Autorzy :
Kim B; Department of Medicine, The Graduate School, Yonsei University College of Medicine, Seoul, Korea.; Division of Translational Science, Center for Colon Cancer, Center for Cancer Prevention and Detection, National Cancer Center, Goyang, Korea.; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
Seo Y; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.; Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.
Kwon JH; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
Shin Y; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.; Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.
Kim S; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
Park SJ; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
Park JJ; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.; Yonsei Cancer Prevention Center, Yonsei University College of Medicine, Seoul, Korea.
Cheon JH; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
Kim WH; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
Il Kim T; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.; Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.; Yonsei Cancer Prevention Center, Yonsei University College of Medicine, Seoul, Korea.
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Źródło :
Molecular carcinogenesis [Mol Carcinog] 2021 Mar; Vol. 60 (3), pp. 188-200. Date of Electronic Publication: 2021 Feb 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Colorectal Neoplasms/*pathology
Interleukin-6/*metabolism
Interleukin-8/*metabolism
Neoplastic Stem Cells/*pathology
Transcription Factor HES-1/*metabolism
Caco-2 Cells ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Culture Media, Conditioned/pharmacology ; Gene Expression Regulation, Neoplastic ; Humans ; Myofibroblasts/metabolism ; Myofibroblasts/pathology ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism ; Organoids/pathology ; STAT3 Transcription Factor/antagonists & inhibitors ; STAT3 Transcription Factor/metabolism ; Transcription Factor HES-1/genetics ; Tumor Microenvironment/drug effects
Czasopismo naukowe

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