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Tytuł :
HPV-induced Nurr1 promotes cancer aggressiveness, self-renewal, and radioresistance via ERK and AKT signaling in cervical cancer.
Autorzy :
Wan PK; Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region of China.
Leung TH; Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region of China.
Siu MK; Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region of China.
Mo XT; Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region of China.
Tang HW; Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region of China.
Chan KK; Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region of China.
Cheung AN; Department of Pathology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region of China.
Ngan HY; Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region of China. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2021 Jan 28; Vol. 497, pp. 14-27. Date of Electronic Publication: 2020 Sep 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Radiation Tolerance*
Biomarkers, Tumor/*metabolism
Neoplastic Stem Cells/*pathology
Nuclear Receptor Subfamily 4, Group A, Member 2/*metabolism
Oncogene Proteins, Viral/*metabolism
Uterine Cervical Neoplasms/*pathology
Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Cell Proliferation ; Female ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Mitogen-Activated Protein Kinase 1/genetics ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/genetics ; Mitogen-Activated Protein Kinase 3/metabolism ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/radiation effects ; Nuclear Receptor Subfamily 4, Group A, Member 2/genetics ; Oncogene Proteins, Viral/genetics ; Papillomaviridae/physiology ; Papillomavirus Infections/complications ; Papillomavirus Infections/metabolism ; Papillomavirus Infections/virology ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; Tumor Cells, Cultured ; Uterine Cervical Neoplasms/metabolism ; Uterine Cervical Neoplasms/radiotherapy ; Uterine Cervical Neoplasms/virology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
ADAM protease inhibition overcomes resistance of breast cancer stem-like cells to γδ T cell immunotherapy.
Autorzy :
Dutta I; Department of Experimental Oncology, University of Alberta, Edmonton, AB, Canada.
Dieters-Castator D; Department of Anatomy and Cell Biology, Western University, London, ON, Canada.
Papatzimas JW; Department of Chemistry, University of Calgary, Calgary, AB, Canada.
Medina A; Department of Experimental Oncology, University of Alberta, Edmonton, AB, Canada.
Schueler J; Charles River Discovery Research Services Germany, Freiburg, Germany.
Derksen DJ; Department of Chemistry, University of Calgary, Calgary, AB, Canada.
Lajoie G; Department of Biochemistry, Western University, London, ON, Canada.
Postovit LM; Department of Experimental Oncology, University of Alberta, Edmonton, AB, Canada.
Siegers GM; Department of Experimental Oncology, University of Alberta, Edmonton, AB, Canada. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2021 Jan 01; Vol. 496, pp. 156-168. Date of Electronic Publication: 2020 Oct 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunotherapy*
ADAM Proteins/*antagonists & inhibitors
Breast Neoplasms/*drug therapy
Drug Resistance, Neoplasm/*drug effects
Gene Expression Regulation, Neoplastic/*drug effects
Intraepithelial Lymphocytes/*immunology
Neoplastic Stem Cells/*drug effects
Protease Inhibitors/*pharmacology
Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Breast Neoplasms/immunology ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Proliferation ; Female ; Humans ; Intraepithelial Lymphocytes/drug effects ; Killer Cells, Natural/drug effects ; Killer Cells, Natural/immunology ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Molecular Targeted Therapy ; Neoplastic Stem Cells/immunology ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Sustained activation of notch signaling maintains tumor-initiating cells in a murine model of liposarcoma.
Autorzy :
Tien PC; Department of Animal Sciences, Purdue University, West Lafayette, IN, 47907, USA.
Quan M; Department of Biological Sciences, Purdue University, West Lafayette, IN, 47907, USA.
Kuang S; Department of Animal Sciences, Purdue University, West Lafayette, IN, 47907, USA; Department of Biological Sciences, Purdue University, West Lafayette, IN, 47907, USA; Center for Cancer Research, Purdue University, West Lafayette, IN, 47907, USA. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2020 Dec 01; Vol. 494, pp. 27-39. Date of Electronic Publication: 2020 Aug 28.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Liposarcoma/*pathology
Neoplasm Transplantation/*methods
Neoplastic Stem Cells/*metabolism
Receptors, Notch/*metabolism
Animals ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Humans ; Liposarcoma/genetics ; Liposarcoma/metabolism ; Mice ; Neoplastic Stem Cells/pathology ; Serial Passage ; Signal Transduction
Czasopismo naukowe
Tytuł :
Differentiated cancer cell-originated lactate promotes the self-renewal of cancer stem cells in patient-derived colorectal cancer organoids.
Autorzy :
Zhao H; Molecular Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yan C; Department of Gastrointestinal Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.
Hu Y; Department of Breast Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.
Mu L; Molecular Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Liu S; Molecular Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Huang K; Molecular Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Li Q; Molecular Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Li X; Molecular Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Tao D; Molecular Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Qin J; Molecular Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2020 Nov 28; Vol. 493, pp. 236-244. Date of Electronic Publication: 2020 Sep 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Colorectal Neoplasms/*pathology
Lactic Acid/*metabolism
Neoplastic Stem Cells/*pathology
Organoids/*transplantation
Animals ; Cell Differentiation ; Cell Proliferation ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Disease Progression ; Gene Expression Regulation, Neoplastic ; Humans ; Mice ; Neoplasm Transplantation ; Neoplastic Stem Cells/metabolism ; Organoids/cytology ; Organoids/metabolism ; Oxidative Phosphorylation ; Tumor Cells, Cultured ; Wnt Signaling Pathway
Czasopismo naukowe
Tytuł :
Kinesin family member 15 promotes cancer stem cell phenotype and malignancy via reactive oxygen species imbalance in hepatocellular carcinoma.
Autorzy :
Li Q; School of Medicine, Southeast University, No.87, Dingjia Bridge, Nanjing, Jiangsu province, China; Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Living Donor Liver Transplantation (Nanjing Medical University), No.300, Guangzhou Road, Nanjing, Jiangsu Province, China.
Qiu J; Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Living Donor Liver Transplantation (Nanjing Medical University), No.300, Guangzhou Road, Nanjing, Jiangsu Province, China.
Yang H; Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, No.300, Guangzhou Road, Nanjing, Jiangsu Province, China.
Sun G; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, No.300, Guangzhou Road, Nanjing, Jiangsu Province, China.
Hu Y; Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Living Donor Liver Transplantation (Nanjing Medical University), No.300, Guangzhou Road, Nanjing, Jiangsu Province, China.
Zhu D; Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Living Donor Liver Transplantation (Nanjing Medical University), No.300, Guangzhou Road, Nanjing, Jiangsu Province, China.
Deng Z; Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Living Donor Liver Transplantation (Nanjing Medical University), No.300, Guangzhou Road, Nanjing, Jiangsu Province, China.
Wang X; School of Medicine, Southeast University, No.87, Dingjia Bridge, Nanjing, Jiangsu province, China; Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Living Donor Liver Transplantation (Nanjing Medical University), No.300, Guangzhou Road, Nanjing, Jiangsu Province, China. Electronic address: .
Tang J; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, No.300, Guangzhou Road, Nanjing, Jiangsu Province, China. Electronic address: .
Jiang R; Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, No.321, Zhongshan Road, Nanjing, Jiangsu Province, China; Medical School of Nanjing University, No.22, Hankou Road, Nanjing, Jiangsu, China. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2020 Jul 10; Vol. 482, pp. 112-125. Date of Electronic Publication: 2019 Nov 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Up-Regulation*
ATPases Associated with Diverse Cellular Activities/*metabolism
Carcinoma, Hepatocellular/*pathology
DNA-Binding Proteins/*metabolism
Kinesin/*metabolism
Liver Neoplasms/*metabolism
Neoplastic Stem Cells/*pathology
Reactive Oxygen Species/*metabolism
Animals ; Carcinoma, Hepatocellular/metabolism ; Cell Line, Tumor ; Female ; Gene Expression Regulation, Neoplastic ; Hep G2 Cells ; Humans ; Male ; Mice ; Neoplasm Metastasis ; Neoplasm Recurrence, Local ; Neoplasm Transplantation ; Neoplastic Stem Cells/metabolism ; Phosphoglycerate Dehydrogenase/metabolism ; Proteasome Endopeptidase Complex/metabolism ; Proteolysis ; Survival Analysis
Czasopismo naukowe
Tytuł :
DNA damage response and resistance of cancer stem cells.
Autorzy :
Abad E; Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain.
Graifer D; Novosibirsk State University, Novosibirsk, Russia.
Lyakhovich A; Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia; Vall D'Hebron Institut de Recerca, 08035, Barcelona, Spain. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2020 Apr 01; Vol. 474, pp. 106-117. Date of Electronic Publication: 2020 Jan 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
DNA Damage*
Drug Resistance, Neoplasm*
Radiation Tolerance*
Antineoplastic Agents/*pharmacology
Neoplasms/*pathology
Neoplastic Stem Cells/*pathology
Animals ; Apoptosis ; Humans ; Neoplasms/genetics ; Neoplasms/therapy ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/radiation effects
Czasopismo naukowe
Tytuł :
Laminin 521 enhances self-renewal via STAT3 activation and promotes tumor progression in colorectal cancer.
Autorzy :
Qin Y; Department of Clinical Pathology, The University of Melbourne, Victorian Comprehensive Cancer Centre, Melbourne, VIC3000, Australia; University of Melbourne Centre for Cancer Research, The University of Melbourne, Victorian Comprehensive Cancer Centre, Melbourne, VIC3000, Australia.
Shembrey C; Department of Clinical Pathology, The University of Melbourne, Victorian Comprehensive Cancer Centre, Melbourne, VIC3000, Australia; University of Melbourne Centre for Cancer Research, The University of Melbourne, Victorian Comprehensive Cancer Centre, Melbourne, VIC3000, Australia.
Smith J; Department of Clinical Pathology, The University of Melbourne, Victorian Comprehensive Cancer Centre, Melbourne, VIC3000, Australia; University of Melbourne Centre for Cancer Research, The University of Melbourne, Victorian Comprehensive Cancer Centre, Melbourne, VIC3000, Australia.
Paquet-Fifield S; Department of Clinical Pathology, The University of Melbourne, Victorian Comprehensive Cancer Centre, Melbourne, VIC3000, Australia; University of Melbourne Centre for Cancer Research, The University of Melbourne, Victorian Comprehensive Cancer Centre, Melbourne, VIC3000, Australia.
Behrenbruch C; Department of Clinical Pathology, The University of Melbourne, Victorian Comprehensive Cancer Centre, Melbourne, VIC3000, Australia; University of Melbourne Centre for Cancer Research, The University of Melbourne, Victorian Comprehensive Cancer Centre, Melbourne, VIC3000, Australia; Division of Cancer Surgery, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre, Parkville, VIC 3010, Australia.
Beyit LM; Department of Clinical Pathology, The University of Melbourne, Victorian Comprehensive Cancer Centre, Melbourne, VIC3000, Australia; University of Melbourne Centre for Cancer Research, The University of Melbourne, Victorian Comprehensive Cancer Centre, Melbourne, VIC3000, Australia.
Thomson BNJ; Division of Cancer Surgery, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre, Parkville, VIC 3010, Australia; University of Melbourne Department of Surgery, Royal Melbourne Hospital, Grattan Street, Parkville, VIC3010, Australia.
Heriot AG; Division of Cancer Surgery, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre, Parkville, VIC 3010, Australia.
Cao Y; Department of Clinical Pathology, The University of Melbourne, Victorian Comprehensive Cancer Centre, Melbourne, VIC3000, Australia; University of Melbourne Centre for Cancer Research, The University of Melbourne, Victorian Comprehensive Cancer Centre, Melbourne, VIC3000, Australia.
Hollande F; Department of Clinical Pathology, The University of Melbourne, Victorian Comprehensive Cancer Centre, Melbourne, VIC3000, Australia; University of Melbourne Centre for Cancer Research, The University of Melbourne, Victorian Comprehensive Cancer Centre, Melbourne, VIC3000, Australia. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2020 Apr 28; Vol. 476, pp. 161-169. Date of Electronic Publication: 2020 Feb 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Self Renewal*
Biomarkers, Tumor/*metabolism
Colorectal Neoplasms/*pathology
Laminin/*metabolism
Liver Neoplasms/*secondary
Neoplastic Stem Cells/*pathology
STAT3 Transcription Factor/*metabolism
Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Cell Proliferation ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Laminin/genetics ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Mice ; Neoplasm Invasiveness ; Neoplastic Stem Cells/metabolism ; Prognosis ; Retrospective Studies ; STAT3 Transcription Factor/genetics ; Signal Transduction ; Survival Rate ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
NRF2/SHH signaling cascade promotes tumor-initiating cell lineage and drug resistance in hepatocellular carcinoma.
Autorzy :
Leung HW; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong.
Lau EYT; Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong.
Leung CON; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong.
Lei MML; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong.
Mok EHK; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong.
Ma VWS; Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong.
Cho WCS; Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong.
Ng IOL; Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong.
Yun JP; Department of Pathology, Sun Yat Sen University Cancer Center, Guangzhou, China.
Cai SH; Department of Pathology, Sun Yat Sen University Cancer Center, Guangzhou, China.
Yu HJ; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ma S; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong.
Lee TKW; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong; State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hong Kong. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2020 Apr 28; Vol. 476, pp. 48-56. Date of Electronic Publication: 2020 Feb 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biomarkers, Tumor/*metabolism
Carcinoma, Hepatocellular/*pathology
Drug Resistance, Neoplasm/*genetics
Hedgehog Proteins/*metabolism
Liver Neoplasms/*pathology
NF-E2-Related Factor 2/*metabolism
Neoplastic Stem Cells/*pathology
Animals ; Antineoplastic Agents/pharmacology ; Apoptosis ; Biomarkers, Tumor/genetics ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/genetics ; Cell Lineage ; Cell Proliferation ; Female ; Gene Expression Regulation, Neoplastic ; Hedgehog Proteins/genetics ; Humans ; Liver Neoplasms/drug therapy ; Liver Neoplasms/genetics ; Male ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Middle Aged ; NF-E2-Related Factor 2/genetics ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/genetics ; Neoplasm Recurrence, Local/pathology ; Neoplastic Stem Cells/metabolism ; Prognosis ; Sorafenib/pharmacology ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
The small molecule drug CBL0137 increases the level of DNA damage and the efficacy of radiotherapy for glioblastoma.
Autorzy :
Tallman MM; Department of Radiation Oncology, James Cancer Hospital and Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, OH, USA; Biomedical Graduate Program, The Ohio State University, Columbus, OH, USA.
Zalenski AA; Department of Radiation Oncology, James Cancer Hospital and Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, OH, USA; Neuroscience Graduate Program, The Ohio State University, Columbus, OH, USA.
Deighen AM; Department of Radiation Oncology, James Cancer Hospital and Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, OH, USA.
Schrock MS; Department of Radiation Oncology, James Cancer Hospital and Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, OH, USA.
Mortach S; Department of Radiation Oncology, James Cancer Hospital and Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, OH, USA.
Grubb TM; Department of Radiation Oncology, James Cancer Hospital and Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, OH, USA.
Kastury PS; Department of Radiation Oncology, James Cancer Hospital and Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, OH, USA.
Huntoon K; Department of Neurological Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Summers MK; Department of Radiation Oncology, James Cancer Hospital and Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, OH, USA.
Venere M; Department of Radiation Oncology, James Cancer Hospital and Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, OH, USA. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2021 Feb 28; Vol. 499, pp. 232-242. Date of Electronic Publication: 2020 Nov 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain Neoplasms/*therapy
Carbazoles/*administration & dosage
Chemoradiotherapy/*methods
Glioblastoma/*therapy
Neoplasm Recurrence, Local/*prevention & control
Radiation-Sensitizing Agents/*administration & dosage
Animals ; Brain Neoplasms/genetics ; Brain Neoplasms/pathology ; Cranial Irradiation ; DNA Damage/drug effects ; DNA Damage/radiation effects ; Female ; Glioblastoma/genetics ; Glioblastoma/pathology ; Humans ; Male ; Mice ; Neoplasm Recurrence, Local/genetics ; Neoplasm Recurrence, Local/pathology ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/pathology ; Neoplastic Stem Cells/radiation effects ; Primary Cell Culture ; Radiation Tolerance/drug effects ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Human telomerase reverse transcriptase depletion potentiates the growth-inhibitory activity of imatinib in chronic myeloid leukemia stem cells.
Autorzy :
Grandjenette C; Laboratoire de Biologie Moléculaire Du Cancer, Hôpital Kirchberg, 9, Rue Edward Steichen, L-2540, Luxembourg.
Schnekenburger M; Laboratoire de Biologie Moléculaire Du Cancer, Hôpital Kirchberg, 9, Rue Edward Steichen, L-2540, Luxembourg.
Gaigneaux A; Laboratoire de Biologie Moléculaire Du Cancer, Hôpital Kirchberg, 9, Rue Edward Steichen, L-2540, Luxembourg.
Gérard D; Laboratoire de Biologie Moléculaire Du Cancer, Hôpital Kirchberg, 9, Rue Edward Steichen, L-2540, Luxembourg.
Christov C; Service Commun de Microscopie, Université de Lorraine, 54000, Nancy, France.
Mazumder A; Department of Pharmacy, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08626, South Korea.
Dicato M; Laboratoire de Biologie Moléculaire Du Cancer, Hôpital Kirchberg, 9, Rue Edward Steichen, L-2540, Luxembourg.
Diederich M; Department of Pharmacy, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08626, South Korea. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2020 Jan 28; Vol. 469, pp. 468-480. Date of Electronic Publication: 2019 Nov 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Imatinib Mesylate/*pharmacology
Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*drug therapy
Neoplastic Stem Cells/*drug effects
Telomerase/*genetics
Aldehyde Dehydrogenase 1 Family/genetics ; Apoptosis/drug effects ; Carcinogenesis/drug effects ; Cell Lineage/genetics ; Cell Proliferation/drug effects ; Disease Progression ; Drug Resistance, Neoplasm/genetics ; Female ; Fusion Proteins, bcr-abl/genetics ; Humans ; K562 Cells ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology ; Male ; Neoplastic Stem Cells/pathology ; Protein Kinase Inhibitors/pharmacology
Czasopismo naukowe
Tytuł :
Humanized anti-CD271 monoclonal antibody exerts an anti-tumor effect by depleting cancer stem cells.
Autorzy :
Morita S; Division of Cancer Stem Cell, Miyagi Cancer Center Research Institute, 47-1, Medeshima-Shiode, Natori, Miyagi, Japan; Department of Head and Neck Surgery, Miyagi Cancer Center, 47-1, Medeshima-Shiode, Natori, Miyagi, Japan.
Mochizuki M; Division of Cancer Stem Cell, Miyagi Cancer Center Research Institute, 47-1, Medeshima-Shiode, Natori, Miyagi, Japan.
Wada K; Research Unit/Innovative Medical Science, Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 1000, Kamoshida-cho, Aoba-ku, Yokohama, Kanagawa, Japan.
Shibuya R; Division of Cancer Stem Cell, Miyagi Cancer Center Research Institute, 47-1, Medeshima-Shiode, Natori, Miyagi, Japan.
Nakamura M; Division of Molecular and Cellular Oncology, Miyagi Cancer Center Research Institute, 47-1, Medeshima-Shiode, Natori, Miyagi, Japan.
Yamaguchi K; Division of Molecular and Cellular Oncology, Miyagi Cancer Center Research Institute, 47-1, Medeshima-Shiode, Natori, Miyagi, Japan.
Yamazaki T; Department of Head and Neck Medical Oncology, Miyagi Cancer Center, 47-1, Medeshima-Shiode, Natori, Miyagi, Japan.
Imai T; Department of Head and Neck Surgery, Miyagi Cancer Center, 47-1, Medeshima-Shiode, Natori, Miyagi, Japan.
Asada Y; Department of Head and Neck Surgery, Miyagi Cancer Center, 47-1, Medeshima-Shiode, Natori, Miyagi, Japan.
Matsuura K; Department of Head and Neck Surgery, Miyagi Cancer Center, 47-1, Medeshima-Shiode, Natori, Miyagi, Japan.
Sugamura K; Division of Molecular and Cellular Oncology, Miyagi Cancer Center Research Institute, 47-1, Medeshima-Shiode, Natori, Miyagi, Japan.
Katori Y; Department of Otolaryngology-Head and Neck Surgery, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, Japan.
Satoh K; Division of Cancer Stem Cell, Miyagi Cancer Center Research Institute, 47-1, Medeshima-Shiode, Natori, Miyagi, Japan; Division of Gastroenterology and Hepatology, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aobaku, Sendai, Miyagi, Japan.
Tamai K; Division of Cancer Stem Cell, Miyagi Cancer Center Research Institute, 47-1, Medeshima-Shiode, Natori, Miyagi, Japan. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2019 Oct 01; Vol. 461, pp. 144-152. Date of Electronic Publication: 2019 Jul 17.
Typ publikacji :
Journal Article
MeSH Terms :
Antibody-Dependent Cell Cytotoxicity*
Antibodies, Monoclonal, Humanized/*pharmacology
Hypopharyngeal Neoplasms/*drug therapy
Lung Neoplasms/*drug therapy
Melanoma/*drug therapy
Neoplastic Stem Cells/*drug effects
Nerve Tissue Proteins/*immunology
Receptors, Nerve Growth Factor/*immunology
Animals ; Antibodies, Monoclonal, Humanized/immunology ; Apoptosis ; Cell Proliferation ; Female ; Humans ; Hypopharyngeal Neoplasms/immunology ; Hypopharyngeal Neoplasms/metabolism ; Hypopharyngeal Neoplasms/pathology ; Lung Neoplasms/immunology ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Melanoma/immunology ; Melanoma/metabolism ; Melanoma/pathology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred NOD ; Mice, SCID ; Neoplastic Stem Cells/immunology ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Interference with the bromodomain epigenome readers drives p21 expression and tumor senescence.
Autorzy :
Webber LP; Laboratory of Epithelial Biology, Department of Periodontics and Oral Medicine, University of Michigan, School of Dentistry, Ann Arbor, MI, 48109, USA; Department of Oral Pathology, School of Dentistry, Federal University of the Rio Grande do Sul, Porto Alegre, RS, 90035-004, Brazil.
Yujra VQ; Laboratory of Epithelial Biology, Department of Periodontics and Oral Medicine, University of Michigan, School of Dentistry, Ann Arbor, MI, 48109, USA; Department of Pathology, Federal University of São Paulo, Sao Paulo, SP, 04023-062, Brazil.
Vargas PA; Oral Diagnosis Department, Piracicaba Dental School, University of Campinas, Piracicaba, SP, 13414-903, Brazil.
Martins MD; Department of Oral Pathology, School of Dentistry, Federal University of the Rio Grande do Sul, Porto Alegre, RS, 90035-004, Brazil.
Squarize CH; Laboratory of Epithelial Biology, Department of Periodontics and Oral Medicine, University of Michigan, School of Dentistry, Ann Arbor, MI, 48109, USA; University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, 48109, USA.
Castilho RM; Laboratory of Epithelial Biology, Department of Periodontics and Oral Medicine, University of Michigan, School of Dentistry, Ann Arbor, MI, 48109, USA; University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, 48109, USA. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2019 Oct 01; Vol. 461, pp. 10-20. Date of Electronic Publication: 2019 Jun 29.
Typ publikacji :
Journal Article
MeSH Terms :
Cellular Senescence*
Epigenome*
Azepines/*pharmacology
Cell Cycle Proteins/*antagonists & inhibitors
Cyclin-Dependent Kinase Inhibitor p21/*metabolism
Head and Neck Neoplasms/*pathology
Neoplastic Stem Cells/*pathology
Transcription Factors/*antagonists & inhibitors
Triazoles/*pharmacology
Animals ; Apoptosis ; Biomarkers, Tumor ; Cell Cycle ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cell Proliferation ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Female ; Gene Expression Regulation, Neoplastic ; Head and Neck Neoplasms/drug therapy ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/metabolism ; Histones/genetics ; Histones/metabolism ; Humans ; Mice ; Mice, Nude ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism ; Prognosis ; Squamous Cell Carcinoma of Head and Neck/drug therapy ; Squamous Cell Carcinoma of Head and Neck/genetics ; Squamous Cell Carcinoma of Head and Neck/metabolism ; Squamous Cell Carcinoma of Head and Neck/secondary ; Survival Rate ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Histone demethylase UTX/KDM6A enhances tumor immune cell recruitment, promotes differentiation and suppresses medulloblastoma.
Autorzy :
Yi J; Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Shi X; Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Xuan Z; Department of Biological Sciences, Center for Systems Biology, University of Texas at Dallas, Richardson, TX, 75080, USA.
Wu J; Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2021 Feb 28; Vol. 499, pp. 188-200. Date of Electronic Publication: 2020 Nov 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cerebellar Neoplasms/*genetics
Histone Demethylases/*metabolism
Medulloblastoma/*genetics
Tumor Suppressor Proteins/*metabolism
Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Cell Differentiation/genetics ; Cell Line, Tumor ; Cerebellar Neoplasms/immunology ; Cerebellar Neoplasms/pathology ; Cerebellum/cytology ; Cerebellum/pathology ; Disease Models, Animal ; Female ; Gene Expression Regulation, Neoplastic/immunology ; Gene Knockdown Techniques ; Histone Demethylases/genetics ; Humans ; Jumonji Domain-Containing Histone Demethylases/genetics ; Jumonji Domain-Containing Histone Demethylases/metabolism ; Lymphocytes, Tumor-Infiltrating/immunology ; Male ; Medulloblastoma/immunology ; Medulloblastoma/pathology ; Mice ; Mice, Transgenic ; Neoplastic Stem Cells/pathology ; Neurons/pathology ; Neuropeptides/genetics ; Primary Cell Culture ; Smoothened Receptor/genetics ; T-Lymphocytes, Cytotoxic/immunology ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology ; Tumor Suppressor Proteins/genetics
Czasopismo naukowe
Tytuł :
lncRNA LINC01057 promotes mesenchymal differentiation by activating NF-κB signaling in glioblastoma.
Autorzy :
Tang G; Department of Neurosurgery, Xiangya Hospital, Central South University, Xiangya Road 87#, Changsha, 410008, Hunan, China.
Luo L; Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, Guangzhou Key Laboratory of 'Translational Medicine on Malignant Tumor Treatment', Hengzhigang Road 78#, Guangzhou, 510095, Guangdong, China.
Zhang J; Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, Guangzhou Key Laboratory of 'Translational Medicine on Malignant Tumor Treatment', Hengzhigang Road 78#, Guangzhou, 510095, Guangdong, China.
Zhai D; Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, Guangzhou Key Laboratory of 'Translational Medicine on Malignant Tumor Treatment', Hengzhigang Road 78#, Guangzhou, 510095, Guangdong, China.
Huang D; Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, Guangzhou Key Laboratory of 'Translational Medicine on Malignant Tumor Treatment', Hengzhigang Road 78#, Guangzhou, 510095, Guangdong, China.
Yin J; Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, Guangzhou Key Laboratory of 'Translational Medicine on Malignant Tumor Treatment', Hengzhigang Road 78#, Guangzhou, 510095, Guangdong, China.
Zhou Q; Department of Oncology, Xiangya Hospital, Central South University, Xiangya Road 87#, Changsha, 410008, Hunan, China. Electronic address: .
Zhang Q; Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, Guangzhou Key Laboratory of 'Translational Medicine on Malignant Tumor Treatment', Hengzhigang Road 78#, Guangzhou, 510095, Guangdong, China. Electronic address: .
Zheng G; Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, Guangzhou Key Laboratory of 'Translational Medicine on Malignant Tumor Treatment', Hengzhigang Road 78#, Guangzhou, 510095, Guangdong, China. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2021 Feb 01; Vol. 498, pp. 152-164. Date of Electronic Publication: 2020 Oct 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain Neoplasms/*genetics
Cell Differentiation/*genetics
Glioblastoma/*genetics
Mesenchymal Stem Cells/*pathology
NF-kappa B/*genetics
RNA, Long Noncoding/*genetics
Signal Transduction/*genetics
Brain Neoplasms/pathology ; Cell Line ; Cell Line, Tumor ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic/genetics ; Glioblastoma/pathology ; HEK293 Cells ; Humans ; Neoplastic Stem Cells/pathology ; Prognosis
Czasopismo naukowe
Tytuł :
HOTAIR and androgen receptor synergistically increase GLI2 transcription to promote tumor angiogenesis and cancer stemness in renal cell carcinoma.
Autorzy :
Bai JY; Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Jin B; Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Ma JB; Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Liu TJ; Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Yang C; Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Chong Y; Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Wang X; Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China; Oncology Research Lab, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an, Shaanxi, China; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, Xi'an, Shaanxi, China.
He D; Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China; Oncology Research Lab, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an, Shaanxi, China; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, Xi'an, Shaanxi, China. Electronic address: .
Guo P; Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China; Oncology Research Lab, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an, Shaanxi, China; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, Xi'an, Shaanxi, China. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2021 Feb 01; Vol. 498, pp. 70-79. Date of Electronic Publication: 2020 Nov 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Renal Cell/*genetics
Kidney Neoplasms/*genetics
Neoplastic Stem Cells/*pathology
Neovascularization, Pathologic/*genetics
Nuclear Proteins/*genetics
RNA, Long Noncoding/*genetics
Receptors, Androgen/*genetics
Transcription, Genetic/*genetics
Zinc Finger Protein Gli2/*genetics
Animals ; Carcinoma, Renal Cell/pathology ; Cell Line ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic/genetics ; HEK293 Cells ; Hedgehog Proteins/genetics ; Human Umbilical Vein Endothelial Cells ; Humans ; Kidney Neoplasms/pathology ; Male ; Mice, Nude ; Neovascularization, Pathologic/pathology ; Platelet-Derived Growth Factor/genetics ; Promoter Regions, Genetic/genetics ; Signal Transduction/genetics ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
Mitochondrial rewiring through mitophagy and mitochondrial biogenesis in cancer stem cells: A potential target for anti-CSC cancer therapy.
Autorzy :
Praharaj PP; Cancer and Cell Death Laboratory, Department of Life Science, National Institute of Technology, Rourkela, 769008, Odisha, India.
Panigrahi DP; Cancer and Cell Death Laboratory, Department of Life Science, National Institute of Technology, Rourkela, 769008, Odisha, India.
Bhol CS; Cancer and Cell Death Laboratory, Department of Life Science, National Institute of Technology, Rourkela, 769008, Odisha, India.
Patra S; Cancer and Cell Death Laboratory, Department of Life Science, National Institute of Technology, Rourkela, 769008, Odisha, India.
Mishra SR; Cancer and Cell Death Laboratory, Department of Life Science, National Institute of Technology, Rourkela, 769008, Odisha, India.
Mahapatra KK; Cancer and Cell Death Laboratory, Department of Life Science, National Institute of Technology, Rourkela, 769008, Odisha, India.
Behera BP; Cancer and Cell Death Laboratory, Department of Life Science, National Institute of Technology, Rourkela, 769008, Odisha, India.
Singh A; Cancer and Cell Death Laboratory, Department of Life Science, National Institute of Technology, Rourkela, 769008, Odisha, India.
Patil S; Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Saudi Arabia.
Bhutia SK; Cancer and Cell Death Laboratory, Department of Life Science, National Institute of Technology, Rourkela, 769008, Odisha, India. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2021 Feb 01; Vol. 498, pp. 217-228. Date of Electronic Publication: 2020 Nov 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Mitochondria/*pathology
Mitochondria/*physiology
Mitophagy/*physiology
Neoplastic Stem Cells/*pathology
Cell Differentiation/physiology ; Drug Resistance, Neoplasm/physiology ; Humans ; Organelle Biogenesis
Czasopismo naukowe
Tytuł :
Tumor-derived extracellular vesicles in breast cancer: From bench to bedside.
Autorzy :
Wang HX; Department of Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, PR China. Electronic address: .
Gires O; Department of Otorhinolaryngology, Grosshadern Medical Center, Ludwig-Maximilians-University of Munich, Marchioninistr. 15, 81377, Munich, Germany; Clinical Cooperation Group Personalized Radiotherapy of Head and Neck Tumors, Helmholtz Zentrum München, Neuherberg, Germany. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2019 Sep 28; Vol. 460, pp. 54-64. Date of Electronic Publication: 2019 Jun 22.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Translational Medical Research*
Tumor Microenvironment*
Breast Neoplasms/*pathology
Extracellular Vesicles/*pathology
Neoplastic Stem Cells/*pathology
Animals ; Antineoplastic Agents/therapeutic use ; Biomarkers, Tumor/metabolism ; Breast Neoplasms/drug therapy ; Breast Neoplasms/immunology ; Breast Neoplasms/metabolism ; Drug Carriers ; Drug Resistance, Neoplasm ; Extracellular Vesicles/drug effects ; Extracellular Vesicles/immunology ; Extracellular Vesicles/metabolism ; Female ; Humans ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/immunology ; Neoplastic Stem Cells/metabolism ; Predictive Value of Tests ; Signal Transduction
Czasopismo naukowe
Tytuł :
Macrophage-expressed CD51 promotes cancer stem cell properties via the TGF-β1/smad2/3 axis in pancreatic cancer.
Autorzy :
Zhang B; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, 510120, China; Department of Pancreatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, 510120, China; Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou,Guangdong Province,510655, China; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, 510655, China.
Ye H; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, 510120, China; Department of Pancreatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, 510120, China.
Ren X; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, 510120, China; Department of Medical Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, 510120, China.
Zheng S; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, 510120, China; Department of Pancreatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, 510120, China.
Zhou Q; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, 510120, China; Department of Pancreatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, 510120, China.
Chen C; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, 510120, China; Department of Urology, State Key Laboratory of Oncology in South China, Sun Yat-sen Memorial Hospital, Guangzhou, Guangdong Province, 510120, China.
Lin Q; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, 510120, China; Department of Pancreatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, 510120, China.
Li G; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, 510120, China; Department of Pancreatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, 510120, China.
Wei L; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, 510120, China; Department of Pancreatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, 510120, China.
Fu Z; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, 510120, China; Department of Pancreatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, 510120, China.
Zhang Y; Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong Province, 510080, China.
Hu C; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, 510120, China; Department of Pancreatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, 510120, China.
Li Z; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, 510120, China; Department of Medical Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, 510120, China. Electronic address: .
Chen R; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, 510120, China; Department of Pancreatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, 510120, China. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2019 Sep 10; Vol. 459, pp. 204-215. Date of Electronic Publication: 2019 Jun 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Pancreatic Ductal/*immunology
Integrin alphaV/*biosynthesis
Macrophages/*immunology
Neoplastic Stem Cells/*immunology
Pancreatic Neoplasms/*immunology
Smad2 Protein/*metabolism
Smad3 Protein/*metabolism
Transforming Growth Factor beta1/*metabolism
Animals ; Carcinoma, Pancreatic Ductal/metabolism ; Carcinoma, Pancreatic Ductal/pathology ; Cell Line, Tumor ; Cell Polarity/immunology ; Female ; Humans ; Integrin alphaV/immunology ; Male ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Middle Aged ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/pathology ; Prognosis ; Signal Transduction ; THP-1 Cells ; Up-Regulation
Czasopismo naukowe
Tytuł :
PAK4 regulates stemness and progression in endocrine resistant ER-positive metastatic breast cancer.
Autorzy :
Santiago-Gómez A; Breast Biology Group, Manchester Breast Centre, Division of Cancer Sciences, Oglesby Cancer Research Building, University of Manchester, Manchester, M20 4GJ, United Kingdom.
Kedward T; Breast Biology Group, Manchester Breast Centre, Division of Cancer Sciences, Oglesby Cancer Research Building, University of Manchester, Manchester, M20 4GJ, United Kingdom.
Simões BM; Breast Biology Group, Manchester Breast Centre, Division of Cancer Sciences, Oglesby Cancer Research Building, University of Manchester, Manchester, M20 4GJ, United Kingdom.
Dragoni I; Cancer Research UK's Commercial Partnerships Team, London, EC1V 4AD, United Kingdom.
NicAmhlaoibh R; Cancer Research UK's Commercial Partnerships Team, London, EC1V 4AD, United Kingdom.
Trivier E; Cancer Research UK's Commercial Partnerships Team, London, EC1V 4AD, United Kingdom.
Sabin V; Cancer Research UK's Commercial Partnerships Team, London, EC1V 4AD, United Kingdom.
Gee JM; Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, CF10 3NB, United Kingdom.
Sims AH; Applied Bioinformatics of Cancer Group, University of Edinburgh Cancer Research Centre, Edinburgh, EH4 2XR, United Kingdom.
Howell SJ; Breast Biology Group, Manchester Breast Centre, Division of Cancer Sciences, Oglesby Cancer Research Building, University of Manchester, Manchester, M20 4GJ, United Kingdom; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, M20 4BX, United Kingdom.
Clarke RB; Breast Biology Group, Manchester Breast Centre, Division of Cancer Sciences, Oglesby Cancer Research Building, University of Manchester, Manchester, M20 4GJ, United Kingdom. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2019 Aug 28; Vol. 458, pp. 66-75. Date of Electronic Publication: 2019 May 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents, Hormonal/*pharmacology
Breast Neoplasms/*drug therapy
Breast Neoplasms/*pathology
Neoplastic Stem Cells/*pathology
Receptors, Estrogen/*metabolism
Tamoxifen/*pharmacology
p21-Activated Kinases/*metabolism
Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Disease Progression ; Down-Regulation ; Drug Resistance, Neoplasm ; Estrogen Receptor Antagonists/pharmacology ; Female ; Fulvestrant/pharmacology ; Gene Expression ; Humans ; MCF-7 Cells ; Meta-Analysis as Topic ; Neoplasm Metastasis ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism ; Prognosis ; Small Molecule Libraries/pharmacology ; p21-Activated Kinases/antagonists & inhibitors ; p21-Activated Kinases/biosynthesis ; p21-Activated Kinases/genetics
Czasopismo naukowe
Tytuł :
Combined Bcl-2/Src inhibition synergize to deplete stem-like breast cancer cells.
Autorzy :
Sun Q; Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA; Department of Pathology, University of California, San Diego, La Jolla, CA, 92093, USA.
Wang Y; Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA; Department of Pathology, University of California, San Diego, La Jolla, CA, 92093, USA.
Desgrosellier JS; Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA; Department of Pathology, University of California, San Diego, La Jolla, CA, 92093, USA. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2019 Aug 10; Vol. 457, pp. 40-46. Date of Electronic Publication: 2019 May 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Apoptosis/*drug effects
Breast Neoplasms/*drug therapy
Bridged Bicyclo Compounds, Heterocyclic/*pharmacology
Dasatinib/*pharmacology
Neoplastic Stem Cells/*drug effects
Protein Kinase Inhibitors/*pharmacology
Proto-Oncogene Proteins c-bcl-2/*antagonists & inhibitors
Sulfonamides/*pharmacology
src-Family Kinases/*antagonists & inhibitors
Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism ; Breast Neoplasms/enzymology ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Female ; Humans ; MCF-7 Cells ; Neoplastic Stem Cells/enzymology ; Neoplastic Stem Cells/pathology ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Signal Transduction ; Spheroids, Cellular ; src-Family Kinases/metabolism
Czasopismo naukowe

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