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Title:
Discrete Mechanistic Target of Rapamycin Signaling Pathways, Stem Cells, and Therapeutic Targets.
Authors:
Jhanwar-Uniyal M; Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA.
Zeller SL; Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA.
Spirollari E; Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA.
Das M; Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA.
Hanft SJ; Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA.
Gandhi CD; Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA.
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Source:
Cells [Cells] 2024 Feb 27; Vol. 13 (5). Date of Electronic Publication: 2024 Feb 27.
Publication Type:
Journal Article; Review
MeSH Terms:
Glioblastoma*/metabolism
Sirolimus*/pharmacology
Neoplastic Stem Cells*/metabolism
Humans ; Intercellular Signaling Peptides and Proteins/therapeutic use ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mechanistic Target of Rapamycin Complex 2/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism
Academic Journal
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Title:
Revealing role of epigenetic modifiers and DNA oxidation in cell-autonomous regulation of Cancer stem cells.
Authors:
Ferrer-Diaz AI; Department of Medicine - Division of Hematology/Oncology, Rutgers, New Jersey Medical School, Newark, NJ, 07103, USA.; Rutgers School of Graduate Studies at New Jersey Medical School, Newark, NJ, USA.
Sinha G; Department of Medicine - Division of Hematology/Oncology, Rutgers, New Jersey Medical School, Newark, NJ, 07103, USA.; Rutgers School of Graduate Studies at New Jersey Medical School, Newark, NJ, USA.
Petryna A; Department of Medicine - Division of Hematology/Oncology, Rutgers, New Jersey Medical School, Newark, NJ, 07103, USA.; Rutgers School of Graduate Studies at New Jersey Medical School, Newark, NJ, USA.
Gonzalez-Bermejo R; University of Puerto Rico, Cayey, PR, Puerto Rico.
Kenfack Y; Department of Medicine - Division of Hematology/Oncology, Rutgers, New Jersey Medical School, Newark, NJ, 07103, USA.; Rutgers School of Graduate Studies at New Jersey Medical School, Newark, NJ, USA.
Adetayo O; Rutgers School of Dental Medicine, Newark, NJ, USA.
Patel SA; Division of Hematology and Oncology, Department of Medicine, UMass Memorial Medical Center, UMass Chan Medical School, Worcester, MA, USA.
Hooda-Nehra A; Department of Medicine - Division of Hematology/Oncology, Rutgers, New Jersey Medical School, Newark, NJ, 07103, USA.; Rutgers Cancer Institute of New Jersey, Newark, NJ, USA.
Rameshwar P; Department of Medicine - Division of Hematology/Oncology, Rutgers, New Jersey Medical School, Newark, NJ, 07103, USA. .
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Cell communication and signaling : CCS [Cell Commun Signal] 2024 Feb 12; Vol. 22 (1), pp. 119. Date of Electronic Publication: 2024 Feb 12.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Neoplastic Stem Cells*/pathology
Neoplasms*/pathology
Humans ; Histones/genetics ; Epigenesis, Genetic ; Methyltransferases/genetics ; DNA ; Intracellular Signaling Peptides and Proteins/genetics
Academic Journal
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Title:
METTL16 promotes liver cancer stem cell self-renewal via controlling ribosome biogenesis and mRNA translation.
Authors:
Xue M; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, 91016, USA.; Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Dong L; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, 91016, USA.; Quantitative Biomedical Research Center, Peter O'Donnell Jr. School of Public Health, UT Southwestern Medical Center, Dallas, TX, 7539, USA.
Zhang H; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, 91016, USA.
Li Y; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, 91016, USA.; Department of Radiation Oncology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, Guangdong, China.
Qiu K; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA.
Zhao Z; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, 91016, USA.; Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Gao M; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, 91016, USA.
Han L; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, 91016, USA.; School of Pharmacy, China Medical University, Shenyang, 110001, Liaoning, China.
Chan AKN; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, 91016, USA.
Li W; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, 91016, USA.
Leung K; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, 91016, USA.
Wang K; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, 91016, USA.
Pokharel SP; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, 91016, USA.
Qing Y; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, 91016, USA.
Liu W; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, 91016, USA.
Wang X; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, 91016, USA.
Ren L; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, 91016, USA.
Bi H; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, 91016, USA.
Yang L; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, 91016, USA.
Shen C; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, 91016, USA.
Chen Z; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, 91016, USA.
Melstrom L; Division of Surgical Oncology, Department of Surgery, Beckman Research Institute of City of Hope Comprehensive Cancer Center, Duarte, CA, 91010, USA.
Li H; Department of Molecular Medicine, City of Hope National Medical Center, Duarte, CA, 91016, USA.
Timchenko N; Division of General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
Deng X; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, 91016, USA.
Huang W; Department of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute, Beckman Research Institute of City of Hope, Duarte, CA, 91010, USA.; Graduate School of Biological Science, City of Hope, Duarte, CA, 91010, USA.
Rosen ST; City of Hope Comprehensive Cancer Center, City of Hope, Duarte, CA, 91010, USA.
Tian J; State Key Laboratory of Medical Genomics, Clinical Trial Center, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Xu L; Quantitative Biomedical Research Center, Peter O'Donnell Jr. School of Public Health, UT Southwestern Medical Center, Dallas, TX, 7539, USA.
Diao J; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA.
Chen CW; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, 91016, USA.; City of Hope Comprehensive Cancer Center, City of Hope, Duarte, CA, 91010, USA.
Chen J; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, 91016, USA.; City of Hope Comprehensive Cancer Center, City of Hope, Duarte, CA, 91010, USA.; Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA, 91010, USA.
Shen B; Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. .
Chen H; Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. .
Su R; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, 91016, USA. .; City of Hope Comprehensive Cancer Center, City of Hope, Duarte, CA, 91010, USA. .
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Journal of hematology & oncology [J Hematol Oncol] 2024 Feb 01; Vol. 17 (1), pp. 7. Date of Electronic Publication: 2024 Feb 01.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Carcinoma, Hepatocellular*/genetics
Carcinoma, Hepatocellular*/pathology
Liver Neoplasms*/genetics
Liver Neoplasms*/pathology
Neoplastic Stem Cells*/pathology
Animals ; Humans ; Mice ; Cell Line, Tumor ; Cell Self Renewal/genetics ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Protein Biosynthesis ; Ribosomes/metabolism ; RNA
Academic Journal
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Title:
SOX2 Expression Does Not Guarantee Cancer Stem Cell-like Characteristics in Lung Adenocarcinoma.
Authors:
Bae SH; Division of Rare and Refractory Cancer, Research Institute, National Cancer Center, Goyang 10408, Republic of Korea.; Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang 10408, Republic of Korea.
Lee KY; Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang 10408, Republic of Korea.; Division of Cancer Biology, Research Institute, National Cancer Center, Goyang 10408, Republic of Korea.
Han S; Division of Rare and Refractory Cancer, Research Institute, National Cancer Center, Goyang 10408, Republic of Korea.
Yun CW; Division of Rare and Refractory Cancer, Research Institute, National Cancer Center, Goyang 10408, Republic of Korea.
Park C; Division of Rare and Refractory Cancer, Research Institute, National Cancer Center, Goyang 10408, Republic of Korea.; Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang 10408, Republic of Korea.
Jang H; Division of Rare and Refractory Cancer, Research Institute, National Cancer Center, Goyang 10408, Republic of Korea.; Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang 10408, Republic of Korea.
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Source:
Cells [Cells] 2024 Jan 24; Vol. 13 (3). Date of Electronic Publication: 2024 Jan 24.
Publication Type:
Journal Article
MeSH Terms:
Adenocarcinoma of Lung*/pathology
Lung Neoplasms*/pathology
Neoplastic Stem Cells*/pathology
SOXB1 Transcription Factors*/genetics
SOXB1 Transcription Factors*/metabolism
Humans ; RNA, Small Interfering/metabolism
Academic Journal
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Title:
A positive feedback between PDIA3P1 and OCT4 promotes the cancer stem cell properties of esophageal squamous cell carcinoma.
Authors:
Huang T; Department of Thoracic Surgery, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, 241001, China.
You Q; Department of Thoracic Surgery, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, 241001, China.
Huang D; Department of Thoracic Surgery, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, 241001, China.
Zhang Y; Department of Thoracic Surgery, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, 241001, China.
He Z; Department of Thoracic Surgery, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, 241001, China.
Shen X; Department of Thoracic Surgery, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, 241001, China.
Li F; Department of Thoracic Surgery, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, 241001, China.
Shen Q; Department of Thoracic Surgery, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, 241001, China.
Onyebuchi IC; Department of Thoracic Surgery, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, 241001, China.
Wu C; Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, 241001, China.
Liu F; Department of Thoracic Surgery, Lishui Branch, Zhongda Hospital Affiliated to Southeast University, Nanjing, 211200, China. .
Zhu S; Department of Thoracic Surgery, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, 241001, China. .
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Cell communication and signaling : CCS [Cell Commun Signal] 2024 Jan 22; Vol. 22 (1), pp. 60. Date of Electronic Publication: 2024 Jan 22.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Esophageal Neoplasms*/genetics
Esophageal Squamous Cell Carcinoma*/genetics
RNA, Long Noncoding*/genetics
RNA, Long Noncoding*/metabolism
Octamer Transcription Factor-3*/genetics
Octamer Transcription Factor-3*/metabolism
Neoplastic Stem Cells*/metabolism
Humans ; RNA ; Ubiquitin-Protein Ligases ; Receptors, Nerve Growth Factor
Academic Journal
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Title:
Downregulation of TAB182 promotes cancer stem-like cell properties and therapeutic resistance in triple-negative breast cancer cells.
Authors:
He H; Department of Radiation Toxicology and Oncology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing, 100850, People's Republic of China.; NHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, 130021, People's Republic of China.
Wang S; Department of Radiation Toxicology and Oncology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing, 100850, People's Republic of China.
Zhang W; Department of Radiation Toxicology and Oncology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing, 100850, People's Republic of China.
Gao S; Department of Radiation Toxicology and Oncology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing, 100850, People's Republic of China.
Guan H; Department of Radiation Toxicology and Oncology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing, 100850, People's Republic of China. .
Zhou P; Department of Radiation Toxicology and Oncology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing, 100850, People's Republic of China. .
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Source:
BMC cancer [BMC Cancer] 2023 Nov 13; Vol. 23 (1), pp. 1101. Date of Electronic Publication: 2023 Nov 13.
Publication Type:
Journal Article
MeSH Terms:
Neoplastic Stem Cells*/metabolism
Triple Negative Breast Neoplasms*/drug therapy
Triple Negative Breast Neoplasms*/genetics
Triple Negative Breast Neoplasms*/metabolism
Telomeric Repeat Binding Protein 1*/genetics
Humans ; Cell Line, Tumor ; Cell Proliferation ; Down-Regulation ; Drug Resistance, Neoplasm/genetics ; Gene Expression Regulation, Neoplastic ; Signal Transduction
Academic Journal
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Title:
Cancer Stem Cells and Androgen Receptor Signaling: Partners in Disease Progression.
Authors:
Quintero JC; Unidad de Investigación en Reproducción Humana, Instituto Nacional de Perinatología-Facultad de Química, Universidad Nacional Autónoma de México, Mexico City 11000, Mexico.
Díaz NF; Departamento de Fisiología y Desarrollo Celular, Instituto Nacional de Perinatología, Mexico City 11000, Mexico.
Rodríguez-Dorantes M; Laboratorio de Oncogenómica, Instituto Nacional de Medicina Genómica, Mexico City 14610, Mexico.
Camacho-Arroyo I; Unidad de Investigación en Reproducción Humana, Instituto Nacional de Perinatología-Facultad de Química, Universidad Nacional Autónoma de México, Mexico City 11000, Mexico.
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International journal of molecular sciences [Int J Mol Sci] 2023 Oct 11; Vol. 24 (20). Date of Electronic Publication: 2023 Oct 11.
Publication Type:
Journal Article; Review
MeSH Terms:
Neoplastic Stem Cells*/metabolism
Prostatic Neoplasms*/metabolism
Receptors, Androgen*/metabolism
Humans ; Male ; Cell Line, Tumor ; Disease Progression ; Signal Transduction
Academic Journal
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Title:
Downregulation of circ-Foxo3 in breast cancer stem-like cells.
Authors:
Kamalabadi-Farahani M; Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran. .
Atashi A; Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Shahroud University of Medical Sciences, Shahroud, Iran.
Eslami MM; Department of Hematology, School of Medicine, Tarbiat Modares University (TMU), Tehran, Iran.
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Source:
BMC research notes [BMC Res Notes] 2023 Jul 03; Vol. 16 (1), pp. 132. Date of Electronic Publication: 2023 Jul 03.
Publication Type:
Journal Article
MeSH Terms:
RNA, Circular*/genetics
Breast Neoplasms*/genetics
Neoplastic Stem Cells*
Forkhead Box Protein O3*/genetics
Spheroids, Cellular ; Gene Expression Regulation, Neoplastic ; Cell Line, Tumor
Academic Journal
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Title:
Cuproptosis engages in c-Myc-mediated breast cancer stemness.
Authors:
Wang R; Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, China.
Xu K; Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, China.
Chen Q; Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, China.
Hu Q; Department of Cardiothoracic Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, China.
Zhang J; Phase I Clinical Trial Center, Fudan University Shanghai Cancer Center, Shanghai, China. .
Guan X; Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, China. .; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Personalized Cancer Medicine, Nanjing Medical University, Nanjing, 211166, China. .
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Source:
Journal of translational medicine [J Transl Med] 2023 Jun 23; Vol. 21 (1), pp. 409. Date of Electronic Publication: 2023 Jun 23.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis*
Proto-Oncogene Proteins c-myc*/genetics
Proto-Oncogene Proteins c-myc*/metabolism
Breast Neoplasms*
Neoplastic Stem Cells*
Copper ; Phenotype ; Humans ; Female
Academic Journal
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Title:
LINC00909 up-regulates pluripotency factors and promotes cancer stemness and metastasis in pancreatic ductal adenocarcinoma by targeting SMAD4.
Authors:
Li Z; Department of General Surgery, Heyuan people's Hospital, Heyuan, 517000, China.; Department of General Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.; Junior Clinical Cooperation Unit Translational Gastrointestinal Oncology and Preclinical Models, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Ma Z; Department of General Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China.
Wang S; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong Province, 510515, China.
Yan Q; Department of General Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.; South China University of Technology School of Medicine, Guangzhou, Guangdong Province, 510006, China.
Zhuang H; Department of Hepatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510080, China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.
Zhou Z; Department of General Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.; South China University of Technology School of Medicine, Guangzhou, Guangdong Province, 510006, China.
Liu C; Department of General Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong Province, 510515, China.
Chen Y; Department of General Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.; South China University of Technology School of Medicine, Guangzhou, Guangdong Province, 510006, China.
Han M; Department of General Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong Province, 510515, China.
Wu Z; Department of General Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong Province, 510515, China.
Huang S; Department of General Surgery, Heyuan people's Hospital, Heyuan, 517000, China.; Department of General Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong Province, 510515, China.; South China University of Technology School of Medicine, Guangzhou, Guangdong Province, 510006, China.
Zhou Q; Department of General Surgery, Hui Ya Hospital of The First Affiliated Hospital, Sun Yat-sen University, Huizhou, Guangdong, 516081, China. .; Department of Liver Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China. .
Hou B; Department of General Surgery, Heyuan people's Hospital, Heyuan, 517000, China. .; Department of General Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China. .; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong Province, 510515, China. .; South China University of Technology School of Medicine, Guangzhou, Guangdong Province, 510006, China. .
Zhang C; Department of General Surgery, Heyuan people's Hospital, Heyuan, 517000, China. .; Department of General Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China. .; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong Province, 510515, China. .; South China University of Technology School of Medicine, Guangzhou, Guangdong Province, 510006, China. .
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Biology direct [Biol Direct] 2024 Mar 19; Vol. 19 (1), pp. 24. Date of Electronic Publication: 2024 Mar 19.
Publication Type:
Journal Article
MeSH Terms:
Carcinoma, Pancreatic Ductal*/genetics
Carcinoma, Pancreatic Ductal*/metabolism
Carcinoma, Pancreatic Ductal*/pathology
Pancreatic Neoplasms*/genetics
Animals ; Humans ; Mice ; Carcinogenesis/genetics ; Cell Line, Tumor ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Phenotype ; Smad4 Protein/genetics ; Smad4 Protein/metabolism ; RNA, Untranslated/genetics
Academic Journal
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Title:
Modeling 5-FU-Induced Chemotherapy Selection of a Drug-Resistant Cancer Stem Cell Subpopulation.
Authors:
Ramović Hamzagić A; Faculty of Medical Sciences, Department of Genetics, University of Kragujevac, 34000 Kragujevac, Serbia.; Serbia for Harm Reduction of Biological and Chemical Hazards, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Cvetković D; Faculty of Medical Sciences, Department of Genetics, University of Kragujevac, 34000 Kragujevac, Serbia.; Serbia for Harm Reduction of Biological and Chemical Hazards, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Gazdić Janković M; Faculty of Medical Sciences, Department of Genetics, University of Kragujevac, 34000 Kragujevac, Serbia.; Serbia for Harm Reduction of Biological and Chemical Hazards, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Milivojević Dimitrijević N; Institute for Information Technologies Kragujevac, University of Kragujevac, Liceja Kneževine Srbije 1A, 34000 Kragujevac, Serbia.
Nikolić D; Institute for Information Technologies Kragujevac, University of Kragujevac, Liceja Kneževine Srbije 1A, 34000 Kragujevac, Serbia.; Bioengineering Research and Development Center (BioIRC), Prvoslava Stojanovica 6, 34000 Kragujevac, Serbia.
Živanović M; Institute for Information Technologies Kragujevac, University of Kragujevac, Liceja Kneževine Srbije 1A, 34000 Kragujevac, Serbia.
Kastratović N; Faculty of Medical Sciences, Department of Genetics, University of Kragujevac, 34000 Kragujevac, Serbia.; Serbia for Harm Reduction of Biological and Chemical Hazards, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Petrović I; Faculty of Medical Sciences, Department of Pathophysiology, University of Kragujevac, 34000 Kragujevac, Serbia.
Nikolić S; Faculty of Medical Sciences, Department of Genetics, University of Kragujevac, 34000 Kragujevac, Serbia.; Serbia for Harm Reduction of Biological and Chemical Hazards, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Jovanović M; Faculty of Sciences, University of Kragujevac, Radoja Domanovića 12, 34000 Kragujevac, Serbia.
Šeklić D; Institute for Information Technologies Kragujevac, University of Kragujevac, Liceja Kneževine Srbije 1A, 34000 Kragujevac, Serbia.
Filipović N; Bioengineering Research and Development Center (BioIRC), Prvoslava Stojanovica 6, 34000 Kragujevac, Serbia.; Faculty of Engineering, University of Kragujevac, Sestre Janjić 6, 34000 Kragujevac, Serbia.
Ljujić B; Faculty of Medical Sciences, Department of Genetics, University of Kragujevac, 34000 Kragujevac, Serbia.; Serbia for Harm Reduction of Biological and Chemical Hazards, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
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Current oncology (Toronto, Ont.) [Curr Oncol] 2024 Feb 25; Vol. 31 (3), pp. 1221-1234. Date of Electronic Publication: 2024 Feb 25.
Publication Type:
Journal Article
MeSH Terms:
Artificial Intelligence*
Neoplasms*/pathology
Humans ; Cell Line, Tumor ; Aldehyde Dehydrogenase 1 Family ; Fluorouracil/pharmacology ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology
Academic Journal
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Title:
Cyclophilin A Inhibitors Suppress Proliferation and Induce Apoptosis of MKN45 Gastric Cancer Stem-like Cells by Regulating CypA/CD147-Mediated Signaling Pathway.
Authors:
Cho HJ; Department of Life Science and Biochemical Engineering, Graduate School, Sun Moon University, Asan 31460, Republic of Korea.
Jung HJ; Department of Life Science and Biochemical Engineering, Graduate School, Sun Moon University, Asan 31460, Republic of Korea.; Department of Pharmaceutical Engineering and Biotechnology, Sun Moon University, Asan 31460, Republic of Korea.; Genome-Based BioIT Convergence Institute, Sun Moon University, Asan 31460, Republic of Korea.
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International journal of molecular sciences [Int J Mol Sci] 2023 Mar 01; Vol. 24 (5). Date of Electronic Publication: 2023 Mar 01.
Publication Type:
Journal Article
MeSH Terms:
Cyclophilin A*/antagonists & inhibitors
Cyclophilin A*/metabolism
Neoplastic Stem Cells*/drug effects
Neoplastic Stem Cells*/metabolism
Stomach Neoplasms*/drug therapy
Antineoplastic Agents*/pharmacology
Basigin*/metabolism
Animals ; Chick Embryo ; Humans ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Neoplasm Recurrence, Local/drug therapy ; Signal Transduction
Academic Journal
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Title:
Osteogenic and Adipogenic Differentiation Potential of Oral Cancer Stem Cells May Offer New Treatment Modalities.
Authors:
Jaksic Karisik M; Department of Human Genetics, School of Dental Medicine, University of Belgrade, Dr. Subotica 8, 11000 Belgrade, Serbia.
Lazarevic M; Department of Human Genetics, School of Dental Medicine, University of Belgrade, Dr. Subotica 8, 11000 Belgrade, Serbia.
Mitic D; Department of Human Genetics, School of Dental Medicine, University of Belgrade, Dr. Subotica 8, 11000 Belgrade, Serbia.
Nikolic N; Department of Human Genetics, School of Dental Medicine, University of Belgrade, Dr. Subotica 8, 11000 Belgrade, Serbia.
Milosevic Markovic M; Department of Human Genetics, School of Dental Medicine, University of Belgrade, Dr. Subotica 8, 11000 Belgrade, Serbia.
Jelovac D; Clinic for Maxillofacial Surgery, School of Dental Medicine, University of Belgrade, Dr. Subotica 8, 11000 Belgrade, Serbia.
Milasin J; Department of Human Genetics, School of Dental Medicine, University of Belgrade, Dr. Subotica 8, 11000 Belgrade, Serbia.
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International journal of molecular sciences [Int J Mol Sci] 2023 Feb 28; Vol. 24 (5). Date of Electronic Publication: 2023 Feb 28.
Publication Type:
Journal Article
MeSH Terms:
Carcinoma, Squamous Cell*/pathology
MicroRNAs*/metabolism
Mouth Neoplasms*/pathology
Neoplastic Stem Cells*/cytology
Neoplastic Stem Cells*/metabolism
Adipogenesis*
Osteogenesis*
Humans
Academic Journal
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Title:
Integration of single-cell RNA-seq and bulk RNA-seq to construct liver hepatocellular carcinoma stem cell signatures to explore their impact on patient prognosis and treatment.
Authors:
Liu L; Department of Ultrasound and Hebei Key Laboratory of Precise Imaging of Inflammation Related Tumors, Affiliated Hospital of Hebei University, Baoding, 071052, China.
Zhang M; Department of Hepatobiliary Surgery, Affiliated Hospital of Hebei University, Baoding, 071052, China.
Cui N; Department of Breast Surgery, Affiliated Hospital of Hebei University, Baoding, 071052, China.
Liu W; Department of Breast Surgery, Affiliated Hospital of Hebei University, Baoding, 071052, China.
Di G; Department of Ultrasound, Affiliated Hospital of Hebei University, Baoding, 071052, China.
Wang Y; Department of Pathology, Affiliated Hospital of Hebei University, Baoding, 071052, China.
Xi X; Central Laboratory, Hebei Key Laboratory of Cancer Radiotherapy and Chemotherapy, Affiliated Hospital of Hebei University, Baoding, 071052, China.
Li H; Central Laboratory, Hebei Key Laboratory of Cancer Radiotherapy and Chemotherapy, Affiliated Hospital of Hebei University, Baoding, 071052, China.
Shen Z; Central Laboratory, Hebei Key Laboratory of Cancer Radiotherapy and Chemotherapy, Affiliated Hospital of Hebei University, Baoding, 071052, China.
Gu M; Department of Ultrasound, Affiliated Hospital of Hebei University, Baoding, 071052, China.
Wang Z; Department of Ultrasound, Affiliated Hospital of Hebei University, Baoding, 071052, China.
Jiang S; Central Laboratory, Hebei Key Laboratory of Cancer Radiotherapy and Chemotherapy, Affiliated Hospital of Hebei University, Baoding, 071052, China.
Liu B; Central Laboratory, Hebei Key Laboratory of Cancer Radiotherapy and Chemotherapy, Affiliated Hospital of Hebei University, Baoding, 071052, China.
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Source:
PloS one [PLoS One] 2024 Apr 18; Vol. 19 (4), pp. e0298004. Date of Electronic Publication: 2024 Apr 18 (Print Publication: 2024).
Publication Type:
Journal Article
MeSH Terms:
Carcinoma, Hepatocellular*/genetics
Carcinoma, Hepatocellular*/therapy
Liver Neoplasms*/genetics
Liver Neoplasms*/therapy
Humans ; Single-Cell Gene Expression Analysis ; RNA-Seq ; Neoplasm Recurrence, Local ; Prognosis ; Neoplastic Stem Cells ; RNA
Academic Journal
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Title:
DNMT1/miR-152-3p/SOS1 signaling axis promotes self-renewal and tumor growth of cancer stem-like cells derived from non-small cell lung cancer.
Authors:
Yuan Q; Department of Preclinical Medicine, Medical College, Hunan Normal University, Changsha, 410013, China.; Key Laboratory of Study and Discover of Small Targeted Molecules of Hunan Province, Changsha, 410013, China.
Wang R; Department of Pathology, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, China.
Li X; Department of Preclinical Medicine, Medical College, Hunan Normal University, Changsha, 410013, China.; Key Laboratory of Study and Discover of Small Targeted Molecules of Hunan Province, Changsha, 410013, China.
Sun F; Department of Preclinical Medicine, Medical College, Hunan Normal University, Changsha, 410013, China.; Key Laboratory of Study and Discover of Small Targeted Molecules of Hunan Province, Changsha, 410013, China.
Lin J; Department of Gynaecology and Obstetrics, Shenshan Medical Center, Memorial Hospital of Sun Yat-sen University, Shanwei, 516500, Guangdong, China.
Fu Z; Department of Thoracic Surgery, The Tenth Affiliated Dongguan Hospital, Southern Medical University (Dongguan People's Hospital), Dongguan, 523000, China. .
Zhang J; Department of Preclinical Medicine, Medical College, Hunan Normal University, Changsha, 410013, China. .; Key Laboratory of Study and Discover of Small Targeted Molecules of Hunan Province, Changsha, 410013, China. .
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Source:
Clinical epigenetics [Clin Epigenetics] 2024 Apr 15; Vol. 16 (1), pp. 55. Date of Electronic Publication: 2024 Apr 15.
Publication Type:
Journal Article
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*/pathology
Lung Neoplasms*/pathology
MicroRNAs*/genetics
MicroRNAs*/metabolism
Humans ; Cell Movement ; Cell Proliferation ; DNA Methylation ; Gene Expression Regulation, Neoplastic ; Neoplastic Stem Cells/metabolism ; Cell Line, Tumor
Academic Journal
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Title:
Informed by Cancer Stem Cells of Solid Tumors: Advances in Treatments Targeting Tumor-Promoting Factors and Pathways.
Authors:
MacLean MR; Department of Pathology, Dalhousie University, Halifax, NS B3H 4R2, Canada.
Walker OL; Department of Pathology, Dalhousie University, Halifax, NS B3H 4R2, Canada.
Arun RP; Department of Pathology, Dalhousie University, Halifax, NS B3H 4R2, Canada.
Fernando W; Department of Pathology, Dalhousie University, Halifax, NS B3H 4R2, Canada.; Department of Biology, Acadia University, Wolfville, NS B4P 2R6, Canada.
Marcato P; Department of Pathology, Dalhousie University, Halifax, NS B3H 4R2, Canada.; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS B3H 4R2, Canada.; Nova Scotia Health Authority, Halifax, NS B3H 4R2, Canada.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2024 Apr 07; Vol. 25 (7). Date of Electronic Publication: 2024 Apr 07.
Publication Type:
Journal Article; Review
MeSH Terms:
Hedgehog Proteins*
Neoplasms*/therapy
Humans ; Immunotherapy ; Neoplastic Stem Cells ; Phototherapy
Academic Journal
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Title:
The Natural Product Secoemestrin C Inhibits Colorectal Cancer Stem Cells via p38-S100A8 Feed-Forward Regulatory Loop.
Authors:
Zhou H; State Key Laboratory of Respiratory Health and Multimorbidity, Key Laboratory of Antibiotic Bioengineering, Ministry of Health, Laboratory of Oncology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Chen M; NHC Key Laboratory of Biotechnology of Antibiotics, National Center for New Microbial Drug Screening, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, 1 Tiantan Xili, Beijing 100050, China.
Zhao C; State Key Laboratory of Respiratory Health and Multimorbidity, Key Laboratory of Antibiotic Bioengineering, Ministry of Health, Laboratory of Oncology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Shao R; State Key Laboratory of Respiratory Health and Multimorbidity, Key Laboratory of Antibiotic Bioengineering, Ministry of Health, Laboratory of Oncology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Xu Y; NHC Key Laboratory of Biotechnology of Antibiotics, National Center for New Microbial Drug Screening, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, 1 Tiantan Xili, Beijing 100050, China.
Zhao W; State Key Laboratory of Respiratory Health and Multimorbidity, Key Laboratory of Antibiotic Bioengineering, Ministry of Health, Laboratory of Oncology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
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Source:
Cells [Cells] 2024 Apr 03; Vol. 13 (7). Date of Electronic Publication: 2024 Apr 03.
Publication Type:
Journal Article
MeSH Terms:
Signal Transduction*
Colorectal Neoplasms*/pathology
Humans ; Cell Transformation, Neoplastic/metabolism ; Up-Regulation ; Neoplastic Stem Cells/pathology
Academic Journal
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Title:
The MDM2-p53 Axis Represents a Therapeutic Vulnerability Unique to Glioma Stem Cells.
Authors:
Nakagawa-Saito Y; Department of Molecular Cancer Science, School of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan.
Mitobe Y; Department of Molecular Cancer Science, School of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan.; Department of Neurosurgery, School of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan.
Togashi K; Department of Molecular Cancer Science, School of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan.; Department of Ophthalmology and Visual Sciences, School of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan.
Suzuki S; Department of Molecular Cancer Science, School of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan.; Department of Clinical Oncology, School of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan.
Sugai A; Department of Molecular Cancer Science, School of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan.
Takenouchi S; Department of Molecular Cancer Science, School of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan.
Nakamura K; Department of Neurosurgery, School of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan.
Sonoda Y; Department of Neurosurgery, School of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan.
Kitanaka C; Department of Molecular Cancer Science, School of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan.; Research Institute for Promotion of Medical Sciences, Faculty of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan.
Okada M; Department of Molecular Cancer Science, School of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2024 Apr 02; Vol. 25 (7). Date of Electronic Publication: 2024 Apr 02.
Publication Type:
Journal Article
MeSH Terms:
Glioblastoma*
Glioma*/drug therapy
Glioma*/genetics
Humans ; Tumor Suppressor Protein p53/genetics ; Apoptosis ; Neoplastic Stem Cells ; Proto-Oncogene Proteins c-mdm2/genetics
Academic Journal
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Title:
Cancer Stem Cells from Definition to Detection and Targeted Drugs.
Authors:
Ruszkowska-Ciastek B; Department of Pathophysiology, Faculty of Pharmacy, Nicolaus Copernicus University, Collegium Medicum, 85-094 Bydgoszcz, Poland.
Kwiatkowska K; Department of Laboratory Diagnostics, Jan Biziel University Hospital No. 2, 85-168 Bydgoszcz, Poland.
Marques-da-Silva D; Laboratory of Separation and Reaction Engineering-Laboratory of Catalysis and Materials (LSRE-LCM), Polytechnic Institute of Leiria, 2411-901 Leiria, Portugal.; Associate Laboratory in Chemical Engineering (ALiCE), Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal.; School of Technology and Management, Polytechnic Institute of Leiria, Morro do Lena-Alto do Vieiro, 2411-901 Leiria, Portugal.
Lagoa R; Laboratory of Separation and Reaction Engineering-Laboratory of Catalysis and Materials (LSRE-LCM), Polytechnic Institute of Leiria, 2411-901 Leiria, Portugal.; Associate Laboratory in Chemical Engineering (ALiCE), Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal.; School of Technology and Management, Polytechnic Institute of Leiria, Morro do Lena-Alto do Vieiro, 2411-901 Leiria, Portugal.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2024 Mar 31; Vol. 25 (7). Date of Electronic Publication: 2024 Mar 31.
Publication Type:
Journal Article; Review
MeSH Terms:
Drug Delivery Systems*
Neoplasms*/drug therapy
Humans ; Biological Assay ; Cell Cycle ; Cell Division ; Neoplastic Stem Cells
Academic Journal
Full Text  Link opens in a new window Full TextDetails
Title:
Hypoxia drives shared and distinct transcriptomic changes in two invasive glioma stem cell lines.
Authors:
Marallano VJ; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Ughetta ME; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Tejero R; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Nanda S; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Ramalingam R; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Stalbow L; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Sattiraju A; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Huang Y; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Ramakrishnan A; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Shen L; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Wojcinski A; Pacific Neuroscience Institute and Saint John's Cancer Institute at Providence Saint John's Health Center, Santa Monica, CA, 90404, USA.
Kesari S; Pacific Neuroscience Institute and Saint John's Cancer Institute at Providence Saint John's Health Center, Santa Monica, CA, 90404, USA.
Zou H; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Tsankov AM; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. .
Friedel RH; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. .
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Source:
Scientific reports [Sci Rep] 2024 Mar 27; Vol. 14 (1), pp. 7246. Date of Electronic Publication: 2024 Mar 27.
Publication Type:
Journal Article
MeSH Terms:
Brain Neoplasms*/genetics
Brain Neoplasms*/pathology
Glioma*/pathology
Glioblastoma*/pathology
Humans ; Hypoxia/genetics ; Hypoxia/metabolism ; Cell Line, Tumor ; Gene Expression Profiling ; Neoplastic Stem Cells/metabolism ; Cell Hypoxia/genetics
Academic Journal
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