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Wyszukujesz frazę ""Nerve Tissue Proteins"" wg kryterium: Temat


Tytuł :
Biochemical and structural basis for YTH domain of human YTHDC1 binding to methylated adenine in DNA.
Autorzy :
Woodcock CB; Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Horton JR; Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Zhou J; Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Bedford MT; Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Blumenthal RM; Department of Medical Microbiology and Immunology, and Program in Bioinformatics, The University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.
Zhang X; Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Cheng X; Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Oct 09; Vol. 48 (18), pp. 10329-10341.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Protein Conformation*
Adenine/*chemistry
Multiprotein Complexes/*chemistry
Nerve Tissue Proteins/*chemistry
RNA Splicing Factors/*chemistry
DNA/chemistry ; DNA/genetics ; DNA/ultrastructure ; DNA, Single-Stranded/chemistry ; DNA, Single-Stranded/genetics ; Histone Demethylases/genetics ; Humans ; Methylation ; Methyltransferases/genetics ; Multiprotein Complexes/genetics ; Multiprotein Complexes/ultrastructure ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/ultrastructure ; Protein Domains/genetics ; RNA Splicing Factors/genetics ; RNA Splicing Factors/ultrastructure ; RNA-Binding Proteins/genetics
Czasopismo naukowe
Tytuł :
Neurological manifestations of COVID-19: available evidences and a new paradigm.
Autorzy :
Khatoon F; Amity Institute of Neuropsychology & Neurosciences, Amity University, Noida, Uttar Pradesh, 201303, India.
Prasad K; Amity Institute of Neuropsychology & Neurosciences, Amity University, Noida, Uttar Pradesh, 201303, India.
Kumar V; Amity Institute of Neuropsychology & Neurosciences, Amity University, Noida, Uttar Pradesh, 201303, India. .
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Źródło :
Journal of neurovirology [J Neurovirol] 2020 Oct; Vol. 26 (5), pp. 619-630. Date of Electronic Publication: 2020 Aug 24.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Betacoronavirus/*pathogenicity
Brain/*metabolism
Coronavirus Infections/*genetics
Host-Pathogen Interactions/*genetics
Nerve Tissue Proteins/*genetics
Pneumonia, Viral/*genetics
Viral Proteins/*genetics
Brain/pathology ; Brain/virology ; Coronavirus Infections/complications ; Coronavirus Infections/pathology ; Coronavirus Infections/virology ; Depression ; Dizziness/complications ; Dizziness/genetics ; Dizziness/pathology ; Dizziness/virology ; Encephalitis/complications ; Encephalitis/genetics ; Encephalitis/pathology ; Encephalitis/virology ; Guillain-Barre Syndrome/complications ; Guillain-Barre Syndrome/genetics ; Guillain-Barre Syndrome/pathology ; Guillain-Barre Syndrome/virology ; Headache/complications ; Headache/genetics ; Headache/pathology ; Headache/virology ; Humans ; Nerve Tissue Proteins/classification ; Nerve Tissue Proteins/metabolism ; Olfaction Disorders/complications ; Olfaction Disorders/genetics ; Olfaction Disorders/pathology ; Olfaction Disorders/virology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/pathology ; Pneumonia, Viral/virology ; Protein Interaction Mapping ; Seizures/complications ; Seizures/genetics ; Seizures/pathology ; Seizures/virology ; Severity of Illness Index ; Stroke/complications ; Stroke/genetics ; Stroke/pathology ; Stroke/virology ; Viral Proteins/metabolism
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
Identifying and treating ROBO1 prostate cancer: An aggressive cancer subtype prevalent in African American patients.
Autorzy :
Ferrari MG; Department of Urology, University of Minnesota, Minneapolis, Minnesota.
Ganaie AA; Department of Urology, University of Minnesota, Minneapolis, Minnesota.
Shabenah A; Masonic Cancer Center, Institute for Health Informatics, University of Minnesota, Minneapolis, Minnesota.
Mansini AP; Department of Urology, University of Minnesota, Minneapolis, Minnesota.
Wang L; Section of Cancer Biology, Hormel Institute, University of Minnesota, Austin, Minnesota.
Murugan P; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota.
Davicioni E; Decipher Biosciences, Inc, San Diego, California.
Wang J; Masonic Cancer Center, Institute for Health Informatics, University of Minnesota, Minneapolis, Minnesota.
Deng Y; Department of Urology, University of Minnesota, Minneapolis, Minnesota.
Hoeppner LH; Section of Cancer Biology, Hormel Institute, University of Minnesota, Austin, Minnesota.
Warlick CA; Department of Urology, University of Minnesota, Minneapolis, Minnesota.
Konety BR; Department of Urology, University of Minnesota, Minneapolis, Minnesota.
Saleem M; Department of Urology, University of Minnesota, Minneapolis, Minnesota.
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Źródło :
The Prostate [Prostate] 2020 Sep; Vol. 80 (13), pp. 1045-1057. Date of Electronic Publication: 2020 Jul 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
African Americans/*genetics
Nerve Tissue Proteins/*genetics
Prostatic Neoplasms/*ethnology
Prostatic Neoplasms/*genetics
Receptors, Immunologic/*genetics
rac GTP-Binding Proteins/*genetics
Animals ; Cell Line, Tumor ; DNA Methylation ; European Continental Ancestry Group/genetics ; Health Status Disparities ; Humans ; Immunohistochemistry ; Male ; Neoplasm Metastasis ; Nerve Tissue Proteins/biosynthesis ; Nerve Tissue Proteins/deficiency ; Promoter Regions, Genetic ; Prostatectomy ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/surgery ; Receptors, Immunologic/biosynthesis ; Receptors, Immunologic/deficiency ; Zebrafish ; rac GTP-Binding Proteins/antagonists & inhibitors ; rac GTP-Binding Proteins/metabolism ; rac1 GTP-Binding Protein/genetics ; rac1 GTP-Binding Protein/metabolism
Czasopismo naukowe
Tytuł :
Musashi1 expression is negatively correlated with numb expression in brain metastases.
Autorzy :
Dong Y; Department of Neurosurgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei China.
Li J
Liu R
Zhao Z
Wang S
Cui K
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Źródło :
Medicine [Medicine (Baltimore)] 2020 Oct 23; Vol. 99 (43), pp. e22000.
Typ publikacji :
Journal Article
MeSH Terms :
Brain Neoplasms/*genetics
Membrane Proteins/*genetics
Nerve Tissue Proteins/*genetics
RNA, Messenger/*metabolism
RNA-Binding Proteins/*genetics
Adult ; Aged ; Brain/metabolism ; Brain Neoplasms/metabolism ; Brain Neoplasms/secondary ; Case-Control Studies ; Female ; Humans ; Immunohistochemistry ; Male ; Membrane Proteins/metabolism ; Middle Aged ; Nerve Tissue Proteins/metabolism ; RNA-Binding Proteins/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Young Adult
Czasopismo naukowe
Tytuł :
Altered expression of the DISC1 gene in peripheral blood of patients with schizophrenia.
Autorzy :
Fu X; Department of Clinical Psychology, Suzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, Jiangsu, China.
Zhang G; Wuxi Mental Health Center of Nanjing Medical University, 156 Qianrong Road, Wuxi, China. .
Liu Y; Department of Clinical Psychology, Suzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, Jiangsu, China.
Zhang L; Department of Clinical Psychology, Suzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, Jiangsu, China.
Zhang F; Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, 264 Guangzhou Road, Nanjing, Jiangsu Province, China. .
Zhou C; School of Computer Science and Telecommunication Engineering, Jiangsu University, Zhenjiang, China. .
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Źródło :
BMC medical genetics [BMC Med Genet] 2020 Oct 02; Vol. 21 (1), pp. 194. Date of Electronic Publication: 2020 Oct 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression*
Leukocytes, Mononuclear/*drug effects
Nerve Tissue Proteins/*genetics
Schizophrenia/*genetics
Adult ; Antipsychotic Agents/therapeutic use ; Female ; Humans ; Leukocytes, Mononuclear/metabolism ; Male ; Middle Aged ; Nerve Tissue Proteins/blood ; Schizophrenia/blood ; Schizophrenia/drug therapy ; Young Adult
Czasopismo naukowe
Tytuł :
Numb ameliorates necrosis and inflammation in acute kidney injury induced by cisplatin.
Autorzy :
Liu Z; Department of Medicine, Xiangnan University, Chenzhou, China.
Li Z; Department of Eye, Chenzhou First People's Hospital, Chenzhou, China.
Chen Z; Department of Pharmacology, Xiangnan University, Chenzhou, China.
Li C; Department of Medicine, Xiangnan University, Chenzhou, China.
Lei L; Department of Medicine, Xiangnan University, Chenzhou, China.
Wu X; Department of Medicine, Xiangnan University, Chenzhou, China.
Li Y; Department of Medicine, Xiangnan University, Chenzhou, China. Electronic address: .
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2020 Oct 01; Vol. 330, pp. 109251. Date of Electronic Publication: 2020 Sep 01.
Typ publikacji :
Journal Article
MeSH Terms :
Acute Kidney Injury/*pathology
Cisplatin/*adverse effects
Inflammation/*prevention & control
Membrane Proteins/*physiology
Necrosis/*prevention & control
Nerve Tissue Proteins/*physiology
Animals ; Cell Count ; Cytokines/metabolism ; Disease Models, Animal ; Inflammation/etiology ; Kidney Tubules, Proximal/pathology ; Mast Cells ; Membrane Proteins/deficiency ; Mice ; Mice, Knockout ; Necrosis/etiology ; Nerve Tissue Proteins/deficiency ; Neutrophils ; Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
Characterization of the C-terminal tail of the Arc protein.
Autorzy :
Boldridge M; Department of Natural Sciences, Hawaii Pacific University, Honolulu, Hawaii, United States of America.
Shimabukuro J; Department of Natural Sciences, Hawaii Pacific University, Honolulu, Hawaii, United States of America.
Nakamatsu K; Department of Natural Sciences, Windward Community College, Kaneohe, Hawaii, United States of America.
Won C; Department of Natural Sciences, Windward Community College, Kaneohe, Hawaii, United States of America.
Jansen C; Laboratory of Immunology and Signal Transduction, School of Natural Sciences and Mathematics, Chaminade University, Honolulu, Hawaii, United States of America.
Turner H; Laboratory of Immunology and Signal Transduction, School of Natural Sciences and Mathematics, Chaminade University, Honolulu, Hawaii, United States of America.
Wang L; Department of Natural Sciences, Hawaii Pacific University, Honolulu, Hawaii, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Sep 29; Vol. 15 (9), pp. e0239870. Date of Electronic Publication: 2020 Sep 29 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytoskeletal Proteins/*chemistry
Nerve Tissue Proteins/*chemistry
Animals ; Cattle ; Cytoskeletal Proteins/genetics ; Humans ; Intrinsically Disordered Proteins/chemistry ; Nerve Tissue Proteins/genetics ; Primates ; Protein Domains ; Rodentia ; Sequence Homology
Czasopismo naukowe
Tytuł :
The Atoh7 remote enhancer provides transcriptional robustness during retinal ganglion cell development.
Autorzy :
Miesfeld JB; Department of Cell Biology and Human Anatomy, University of California Davis School of Medicine, Davis, CA 95616.
Ghiasvand NM; Department of Biology, Grand Valley State University, Allendale, MI 49401.; Functional Neurosurgery Research Center, Shohada Tajrish Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Marsh-Armstrong B; Department of Ophthalmology and Vision Science, University of California Davis School of Medicine, Sacramento, CA 95817.
Marsh-Armstrong N; Department of Ophthalmology and Vision Science, University of California Davis School of Medicine, Sacramento, CA 95817.
Miller EB; Department of Cell Biology and Human Anatomy, University of California Davis School of Medicine, Davis, CA 95616.
Zhang P; Department of Cell Biology and Human Anatomy, University of California Davis School of Medicine, Davis, CA 95616.
Manna SK; Department of Cell Biology and Human Anatomy, University of California Davis School of Medicine, Davis, CA 95616.
Zawadzki RJ; Department of Ophthalmology and Vision Science, University of California Davis School of Medicine, Sacramento, CA 95817.
Brown NL; Department of Cell Biology and Human Anatomy, University of California Davis School of Medicine, Davis, CA 95616.
Glaser T; Department of Cell Biology and Human Anatomy, University of California Davis School of Medicine, Davis, CA 95616; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Sep 01; Vol. 117 (35), pp. 21690-21700. Date of Electronic Publication: 2020 Aug 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Basic Helix-Loop-Helix Transcription Factors/*metabolism
Nerve Tissue Proteins/*metabolism
Retinal Ganglion Cells/*metabolism
Retinal Ganglion Cells/*physiology
Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Cell Differentiation ; Embryo, Mammalian/metabolism ; Female ; Gene Expression Regulation, Developmental/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Nerve Tissue Proteins/genetics ; Neurogenesis/physiology ; Optic Nerve/metabolism ; Regulatory Sequences, Nucleic Acid/genetics ; Retina/metabolism ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
The necdin interactome: evaluating the effects of amino acid substitutions and cell stress using proximity-dependent biotinylation (BioID) and mass spectrometry.
Autorzy :
Sanderson MR; Department of Medical Genetics, University of Alberta, Edmonton, AB, Canada.
Badior KE; Department of Biochemistry, University of Alberta, Edmonton, AB, Canada.; Membrane Protein Disease Research Group, University of Alberta, Edmonton, AB, Canada.
Fahlman RP; Department of Biochemistry, University of Alberta, Edmonton, AB, Canada.; Department of Oncology, University of Alberta, Edmonton, AB, Canada.
Wevrick R; Department of Medical Genetics, University of Alberta, Edmonton, AB, Canada. .
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Źródło :
Human genetics [Hum Genet] 2020 Dec; Vol. 139 (12), pp. 1513-1529. Date of Electronic Publication: 2020 Jun 11.
Typ publikacji :
Journal Article
MeSH Terms :
Amino Acid Substitution/*genetics
Nerve Tissue Proteins/*genetics
Nuclear Proteins/*genetics
Protein Interaction Maps/*genetics
Ubiquitin-Protein Ligases/*genetics
Animals ; Biotinylation/genetics ; Cell Differentiation/genetics ; Deubiquitinating Enzymes/genetics ; Gene Expression Regulation/genetics ; HEK293 Cells ; Humans ; Mass Spectrometry/methods ; Mice ; Mutation/genetics ; Nerve Tissue Proteins/chemistry ; Nerve Tissue Proteins/ultrastructure ; Nervous System Malformations/genetics ; Nervous System Malformations/pathology ; Neurons/metabolism ; Nuclear Proteins/chemistry ; Nuclear Proteins/ultrastructure ; Poly(A)-Binding Proteins/chemistry ; Poly(A)-Binding Proteins/genetics ; Prader-Willi Syndrome/genetics ; Protein Conformation ; Structure-Activity Relationship ; Ubiquitin-Protein Ligases/chemistry
Czasopismo naukowe
Tytuł :
A lower X-gate in TASK channels traps inhibitors within the vestibule.
Autorzy :
Rödström KEJ; Structural Genomics Consortium, University of Oxford, Oxford, UK.
Kiper AK; Institute for Physiology and Pathophysiology, Vegetative Physiology and Marburg Center for Mind, Brain and Behavior - MCMBB, University of Marburg, Marburg, Germany.
Zhang W; Structural Genomics Consortium, University of Oxford, Oxford, UK.; Public Technology Service Center and CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Rinné S; Institute for Physiology and Pathophysiology, Vegetative Physiology and Marburg Center for Mind, Brain and Behavior - MCMBB, University of Marburg, Marburg, Germany.
Pike ACW; Structural Genomics Consortium, University of Oxford, Oxford, UK.
Goldstein M; Institute for Physiology and Pathophysiology, Vegetative Physiology and Marburg Center for Mind, Brain and Behavior - MCMBB, University of Marburg, Marburg, Germany.
Conrad LJ; Department of Physics, University of Oxford, Oxford, UK.; Department of Biomedical Science, University of Sheffield, Sheffield, UK.
Delbeck M; Bayer AG, Research & Development, Pharmaceuticals, Wuppertal, Germany.
Hahn MG; Bayer AG, Research & Development, Pharmaceuticals, Wuppertal, Germany.
Meier H; Bayer AG, Research & Development, Pharmaceuticals, Wuppertal, Germany.
Platzk M; Bayer AG, Research & Development, Pharmaceuticals, Wuppertal, Germany.
Quigley A; Structural Genomics Consortium, University of Oxford, Oxford, UK.; Membrane Protein Laboratory, Research Complex at Harwell, Harwell, UK.
Speedman D; Structural Genomics Consortium, University of Oxford, Oxford, UK.
Shrestha L; Structural Genomics Consortium, University of Oxford, Oxford, UK.
Mukhopadhyay SMM; Structural Genomics Consortium, University of Oxford, Oxford, UK.
Burgess-Brown NA; Structural Genomics Consortium, University of Oxford, Oxford, UK.
Tucker SJ; Department of Physics, University of Oxford, Oxford, UK.
Müller T; Bayer AG, Research & Development, Pharmaceuticals, Wuppertal, Germany.
Decher N; Institute for Physiology and Pathophysiology, Vegetative Physiology and Marburg Center for Mind, Brain and Behavior - MCMBB, University of Marburg, Marburg, Germany. .
Carpenter EP; Structural Genomics Consortium, University of Oxford, Oxford, UK. .
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Źródło :
Nature [Nature] 2020 Jun; Vol. 582 (7812), pp. 443-447. Date of Electronic Publication: 2020 Apr 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Nerve Tissue Proteins/*antagonists & inhibitors
Nerve Tissue Proteins/*chemistry
Potassium Channels, Tandem Pore Domain/*antagonists & inhibitors
Potassium Channels, Tandem Pore Domain/*chemistry
Anesthetics/pharmacology ; Animals ; Crystallography, X-Ray ; Electric Conductivity ; Female ; Humans ; Ion Channel Gating/drug effects ; Models, Molecular ; Mutation ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Oocytes/drug effects ; Oocytes/metabolism ; Patch-Clamp Techniques ; Potassium Channels, Tandem Pore Domain/genetics ; Potassium Channels, Tandem Pore Domain/metabolism ; Xenopus laevis
Czasopismo naukowe
Tytuł :
A synthetic synaptic organizer protein restores glutamatergic neuronal circuits.
Autorzy :
Suzuki K; Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan.
Elegheert J; Division of Structural Biology, University of Oxford, Oxford OX3 7BN, UK.
Song I; Molecular Neuroplasticity, German Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany.
Sasakura H; Department of Medical Cell Biology, School of Medicine, Aichi Medical University, Aichi, Japan.
Senkov O; Molecular Neuroplasticity, German Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany.
Matsuda K; Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan.
Kakegawa W; Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan.
Clayton AJ; Division of Structural Biology, University of Oxford, Oxford OX3 7BN, UK.
Chang VT; Division of Structural Biology, University of Oxford, Oxford OX3 7BN, UK.; Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Ferrer-Ferrer M; Molecular Neuroplasticity, German Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany.
Miura E; Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan.
Kaushik R; Molecular Neuroplasticity, German Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany.; Center for Behavioral Brain Sciences (CBBS), 39106 Magdeburg, Germany.
Ikeno M; Department of Medical Cell Biology, School of Medicine, Aichi Medical University, Aichi, Japan.
Morioka Y; Department of Medical Cell Biology, School of Medicine, Aichi Medical University, Aichi, Japan.
Takeuchi Y; Department of Medical Cell Biology, School of Medicine, Aichi Medical University, Aichi, Japan.
Shimada T; Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan.
Otsuka S; Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan.
Stoyanov S; Molecular Neuroplasticity, German Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany.
Watanabe M; Department of Anatomy, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan.
Takeuchi K; Department of Medical Cell Biology, School of Medicine, Aichi Medical University, Aichi, Japan.
Dityatev A; Molecular Neuroplasticity, German Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany. .; Center for Behavioral Brain Sciences (CBBS), 39106 Magdeburg, Germany.; Medical Faculty, Otto von Guericke University, 39120 Magdeburg, Germany.
Aricescu AR; Division of Structural Biology, University of Oxford, Oxford OX3 7BN, UK. .; Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Yuzaki M; Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan. .
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Źródło :
Science (New York, N.Y.) [Science] 2020 Aug 28; Vol. 369 (6507).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
C-Reactive Protein/*pharmacology
Nerve Tissue Proteins/*pharmacology
Neural Pathways/*drug effects
Protein Precursors/*pharmacology
Receptors, AMPA/*metabolism
Recombinant Proteins/*pharmacology
Synapses/*drug effects
Alzheimer Disease/therapy ; Animals ; C-Reactive Protein/chemistry ; C-Reactive Protein/therapeutic use ; Cerebellar Ataxia/therapy ; Disease Models, Animal ; HEK293 Cells ; Hippocampus ; Humans ; Mice ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Nerve Tissue Proteins/chemistry ; Nerve Tissue Proteins/therapeutic use ; Protein Domains ; Protein Precursors/chemistry ; Protein Precursors/therapeutic use ; Receptors, Glutamate/genetics ; Recombinant Proteins/chemistry ; Recombinant Proteins/therapeutic use ; Spine/drug effects ; Spine/physiology
Czasopismo naukowe
Tytuł :
Structures of human pannexin 1 reveal ion pathways and mechanism of gating.
Autorzy :
Ruan Z; Van Andel Institute, Grand Rapids, MI, USA.
Orozco IJ; Van Andel Institute, Grand Rapids, MI, USA.
Du J; Van Andel Institute, Grand Rapids, MI, USA. .
Lü W; Van Andel Institute, Grand Rapids, MI, USA. .
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Źródło :
Nature [Nature] 2020 Aug; Vol. 584 (7822), pp. 646-651. Date of Electronic Publication: 2020 Jun 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cryoelectron Microscopy*
Ion Channel Gating*/drug effects
Patch-Clamp Techniques*
Connexins/*chemistry
Connexins/*metabolism
Nerve Tissue Proteins/*chemistry
Nerve Tissue Proteins/*metabolism
Adenosine Triphosphate/metabolism ; Animals ; Apoproteins/chemistry ; Apoproteins/metabolism ; Apoproteins/ultrastructure ; Apoptosis ; Binding Sites/drug effects ; Carbenoxolone/chemistry ; Carbenoxolone/metabolism ; Carbenoxolone/pharmacology ; Caspase 7/metabolism ; Cell Line ; Connexins/ultrastructure ; Gap Junctions ; Glycosylation ; Humans ; Models, Molecular ; Mutation ; Nerve Tissue Proteins/ultrastructure ; Protein Subunits/chemistry ; Protein Subunits/metabolism ; Sf9 Cells
Czasopismo naukowe
Tytuł :
Reciprocal regulation of hnRNP C and CELF2 through translation and transcription tunes splicing activity in T cells.
Autorzy :
Mallory MJ; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
McClory SP; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Chatrikhi R; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Gazzara MR; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ontiveros RJ; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Lynch KW; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Jun 04; Vol. 48 (10), pp. 5710-5719.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Gene Expression Regulation*
Protein Biosynthesis*
RNA Splicing*
Transcription, Genetic*
CELF Proteins/*metabolism
Heterogeneous-Nuclear Ribonucleoprotein Group C/*metabolism
Nerve Tissue Proteins/*metabolism
CELF Proteins/biosynthesis ; CELF Proteins/genetics ; Heterogeneous-Nuclear Ribonucleoprotein Group C/biosynthesis ; Heterogeneous-Nuclear Ribonucleoprotein Group C/genetics ; Humans ; Jurkat Cells ; Nerve Tissue Proteins/biosynthesis ; Nerve Tissue Proteins/genetics ; T-Lymphocytes/metabolism
Czasopismo naukowe
Tytuł :
Loss of Function of RIMS2 Causes a Syndromic Congenital Cone-Rod Synaptic Disease with Neurodevelopmental and Pancreatic Involvement.
Autorzy :
Mechaussier S; Laboratory of Genetics in Ophthalmology, INSERM UMR 1163, Institute of Genetic Diseases, Imagine and Paris University, 75015 Paris, France.
Almoallem B; Center for Medical Genetics and Department of Biomolecular Medicine, Ghent University and Ghent University Hospital, 9000 Ghent, Belgium; Department of Ophthalmology, King Abdul-Aziz University Hospital, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Zeitz C; Sorbonne Université, INSERM, Centre National de la Recherche Scientifique, Institut de la Vision, 75012 Paris, France.
Van Schil K; Center for Medical Genetics and Department of Biomolecular Medicine, Ghent University and Ghent University Hospital, 9000 Ghent, Belgium.
Jeddawi L; Pediatric Ophthalmology Division, Dhahran Eye Specialist Hospital, Dhahran 34257, Saudi Arabia.
Van Dorpe J; Department of Pathology, Ghent University and Ghent University Hospital, 9000 Ghent, Belgium.
Dueñas Rey A; Center for Medical Genetics and Department of Biomolecular Medicine, Ghent University and Ghent University Hospital, 9000 Ghent, Belgium.
Condroyer C; Sorbonne Université, INSERM, Centre National de la Recherche Scientifique, Institut de la Vision, 75012 Paris, France.
Pelle O; Cell Sorting Facility, INSERM UMR 1163, Institute of Genetic Diseases, Imagine and Paris University, 75015 Paris, France.
Polak M; Endocrinology, Gynecology, and Pediatric Diabetology Department, University Hospital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France.
Boddaert N; Department of Pediatric Radiology, University Hospital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France.
Bahi-Buisson N; Pediatric Neurology Department, University Hospital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France.
Cavallin M; Laboratory of Embryology and Genetics of Human Malformation, INSERM UMR 1163, Institute of Genetic Diseases, Imagine and Paris University, 75015 Paris, France.
Bacquet JL; Service d'Ophtalmologie, Centre Hospitalier Intercommunal de Créteil, Assistance Publique-Hôpitaux de Paris, 94000 Créteil, France.
Mouallem-Bézière A; Service d'Ophtalmologie, Centre Hospitalier Intercommunal de Créteil, Assistance Publique-Hôpitaux de Paris, 94000 Créteil, France.
Zambrowski O; Service d'Ophtalmologie, Centre Hospitalier Intercommunal de Créteil, Assistance Publique-Hôpitaux de Paris, 94000 Créteil, France; Ophthalmology Department, University Hospital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France.
Sahel JA; Sorbonne Université, INSERM, Centre National de la Recherche Scientifique, Institut de la Vision, 75012 Paris, France; Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, INSERM, Direction de l'Hospitalisation et de l'Organisation des Soins (DHOS), Centres d'Investigations Cliniques (CIC) 1423, 75012 Paris, France; Fondation Ophtalmologique Adolphe de Rothschild, 75019 Paris, France; Académie des Sciences, Institut de France, 75006 Paris, France; Department of Ophthalmology, The University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, PA 15213, USA.
Audo I; Sorbonne Université, INSERM, Centre National de la Recherche Scientifique, Institut de la Vision, 75012 Paris, France; Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, INSERM, Direction de l'Hospitalisation et de l'Organisation des Soins (DHOS), Centres d'Investigations Cliniques (CIC) 1423, 75012 Paris, France; Institute of Ophthalmology, University College of London, London EC1V 9EL, UK.
Kaplan J; Laboratory of Genetics in Ophthalmology, INSERM UMR 1163, Institute of Genetic Diseases, Imagine and Paris University, 75015 Paris, France; Service d'Ophtalmologie, Centre Hospitalier Intercommunal de Créteil, Assistance Publique-Hôpitaux de Paris, 94000 Créteil, France.
Rozet JM; Laboratory of Genetics in Ophthalmology, INSERM UMR 1163, Institute of Genetic Diseases, Imagine and Paris University, 75015 Paris, France.
De Baere E; Center for Medical Genetics and Department of Biomolecular Medicine, Ghent University and Ghent University Hospital, 9000 Ghent, Belgium. Electronic address: .
Perrault I; Laboratory of Genetics in Ophthalmology, INSERM UMR 1163, Institute of Genetic Diseases, Imagine and Paris University, 75015 Paris, France. Electronic address: .
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Źródło :
American journal of human genetics [Am J Hum Genet] 2020 Jun 04; Vol. 106 (6), pp. 859-871. Date of Electronic Publication: 2020 May 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Loss of Function Mutation*
Eye Diseases, Hereditary/*genetics
GTP-Binding Proteins/*genetics
Genetic Diseases, X-Linked/*genetics
Myopia/*genetics
Nerve Tissue Proteins/*genetics
Night Blindness/*genetics
Adult ; Alleles ; Alternative Splicing ; Brain/metabolism ; Cell Line ; Child ; Child, Preschool ; Diagnosis, Differential ; Family Health ; Female ; France ; GTP-Binding Proteins/chemistry ; GTP-Binding Proteins/metabolism ; Glucose/metabolism ; Humans ; Insulin Secretion ; Male ; Nerve Tissue Proteins/chemistry ; Nerve Tissue Proteins/metabolism ; Pancreas/metabolism ; Pedigree ; Retina/metabolism ; Saudi Arabia ; Senegal
SCR Disease Name :
Night blindness, congenital stationary
Czasopismo naukowe
Tytuł :
Desensitization of NMDA channels requires ligand binding to both GluN1 and GluN2 subunits to constrict the pore beside the activation gate.
Autorzy :
Chen YS; Department of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan.
Tu YC; Department of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan.
Lai YC; Department of Biomedical Sciences, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan.
Liu E; Department of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan.
Yang YC; Department of Biomedical Sciences, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan.; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan.; Neuroscience Research Center, Chang Gung Memorial Hospital, Linkou Medical Center, Tao-Yuan, Taiwan.
Kuo CC; Department of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan.; Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan.
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Źródło :
Journal of neurochemistry [J Neurochem] 2020 Jun; Vol. 153 (5), pp. 549-566. Date of Electronic Publication: 2019 Dec 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glutamic Acid/*metabolism
Glycine/*metabolism
Ion Channel Gating/*physiology
Nerve Tissue Proteins/*metabolism
Receptors, N-Methyl-D-Aspartate/*metabolism
Animals ; Dose-Response Relationship, Drug ; Excitatory Amino Acid Agonists/metabolism ; Excitatory Amino Acid Agonists/pharmacology ; Excitatory Amino Acid Antagonists/metabolism ; Excitatory Amino Acid Antagonists/pharmacology ; Female ; Glutamic Acid/pharmacology ; Glycine/pharmacology ; Ion Channel Gating/drug effects ; Ligands ; Nerve Tissue Proteins/agonists ; Nerve Tissue Proteins/antagonists & inhibitors ; Protein Binding/drug effects ; Protein Binding/physiology ; Rats ; Receptors, N-Methyl-D-Aspartate/agonists ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors ; Receptors, N-Methyl-D-Aspartate/genetics ; Xenopus laevis
Czasopismo naukowe
Tytuł :
Necdin regulates BMAL1 stability and circadian clock through SGT1-HSP90 chaperone machinery.
Autorzy :
Lu R; Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410078, Hunan, P. R. China.; Hunan Key Laboratory of Animal Models for Human Diseases, Changsha 410078, Hunan, P. R. China.
Dong Y; Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410078, Hunan, P. R. China.
Li JD; Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410078, Hunan, P. R. China.; Hunan Key Laboratory of Animal Models for Human Diseases, Changsha 410078, Hunan, P. R. China.; Hunan Key Laboratory of Medical Genetics, Changsha 410078, Hunan, P. R. China.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Aug 20; Vol. 48 (14), pp. 7944-7957.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Circadian Clocks*/genetics
ARNTL Transcription Factors/*metabolism
Adaptor Proteins, Signal Transducing/*metabolism
Cell Cycle Proteins/*metabolism
HSP90 Heat-Shock Proteins/*metabolism
Nerve Tissue Proteins/*metabolism
Nuclear Proteins/*metabolism
Animals ; Gene Expression ; Mice ; Nerve Tissue Proteins/genetics ; Nuclear Proteins/genetics ; Proteasome Endopeptidase Complex/metabolism ; Protein Stability ; Ubiquitin/metabolism
Czasopismo naukowe
Tytuł :
Loss of Hap1 selectively promotes striatal degeneration in Huntington disease mice.
Autorzy :
Liu Q; Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322.; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Xiangya Hospital, Central South University, Changsha 410008, China.
Cheng S; Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322.
Yang H; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322.
Zhu L; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322.
Pan Y; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322.; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Xiangya Hospital, Central South University, Changsha 410008, China.
Jing L; Department of Emergency, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, China.
Tang B; Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Xiangya Hospital, Central South University, Changsha 410008, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China.; Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410008, China.
Li S; Guangdong-Hongkong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, Guangzhou 510632, China.
Li XJ; Guangdong-Hongkong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, Guangzhou 510632, China .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Aug 18; Vol. 117 (33), pp. 20265-20273. Date of Electronic Publication: 2020 Aug 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Optogenetics*
Corpus Striatum/*pathology
Huntington Disease/*metabolism
Nerve Tissue Proteins/*metabolism
Neurons/*physiology
Animals ; Corpus Striatum/metabolism ; Dependovirus ; Gene Expression Regulation ; Huntington Disease/genetics ; Lasers ; Light ; Mice ; Nerve Net ; Nerve Tissue Proteins/genetics
Czasopismo naukowe
Tytuł :
SLIT2/ROBO1-signaling inhibits macropinocytosis by opposing cortical cytoskeletal remodeling.
Autorzy :
Bhosle VK; Program in Cell Biology, The Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, 686 Bay Street, Toronto, ON, M5G 0A4, Canada.
Mukherjee T; Department of Immunology, University of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.
Huang YW; Program in Cell Biology, The Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, 686 Bay Street, Toronto, ON, M5G 0A4, Canada.
Patel S; Program in Cell Biology, The Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, 686 Bay Street, Toronto, ON, M5G 0A4, Canada.
Pang BWF; Program in Cell Biology, The Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, 686 Bay Street, Toronto, ON, M5G 0A4, Canada.; Institute of Medical Science, University of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.; BenchSci, Suite 201, 559 College Street, Toronto, ON, M6G 1A9, Canada.
Liu GY; Program in Cell Biology, The Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, 686 Bay Street, Toronto, ON, M5G 0A4, Canada.
Glogauer M; Faculty of Dentistry, University of Toronto, 101 Elm Street, Toronto, ON, M5G 2L3, Canada.; Department of Dental Oncology and Maxillofacial Prosthetics, University Health Network, Princess Margaret Cancer Centre, 610 University Avenue, Toronto, ON, M5G 2C1, Canada.; Centre for Advanced Dental Research and Care, Mount Sinai Hospital, 600 University Avenue, Toronto, ON, M5G 1X5, Canada.
Wu JY; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.; Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.; Lurie Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Philpott DJ; Department of Immunology, University of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.
Grinstein S; Program in Cell Biology, The Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, 686 Bay Street, Toronto, ON, M5G 0A4, Canada.; Department of Biochemistry, University of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.; Keenan Research Centre of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, 290 Victoria Street, Toronto, ON, M5C 1N8, Canada.
Robinson LA; Program in Cell Biology, The Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, 686 Bay Street, Toronto, ON, M5G 0A4, Canada. .; Institute of Medical Science, University of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada. .; Division of Nephrology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada. .; Department of Paediatrics, Faculty of Medicine, University of Toronto, 555 University Avenue, Toronto, ON, M5G 1X8, Canada. .
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Źródło :
Nature communications [Nat Commun] 2020 Aug 17; Vol. 11 (1), pp. 4112. Date of Electronic Publication: 2020 Aug 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytoskeleton/*metabolism
Intercellular Signaling Peptides and Proteins/*metabolism
Nerve Tissue Proteins/*metabolism
Receptors, Immunologic/*metabolism
Animals ; Chemokine CXCL1/metabolism ; Enzyme-Linked Immunosorbent Assay ; Female ; Intercellular Signaling Peptides and Proteins/genetics ; Macrophages/metabolism ; Male ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice ; Mice, Inbred C57BL ; NF-kappa B/metabolism ; Nerve Tissue Proteins/genetics ; Phagocytes/metabolism ; Pinocytosis/genetics ; Pinocytosis/physiology ; Receptors, Immunologic/genetics ; Signal Transduction/genetics ; Signal Transduction/physiology ; rhoA GTP-Binding Protein/metabolism
Czasopismo naukowe
Tytuł :
Reversal of pre-existing NGFR-driven tumor and immune therapy resistance.
Autorzy :
Boshuizen J; Division of Molecular Oncology and Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Vredevoogd DW; Division of Molecular Oncology and Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Krijgsman O; Division of Molecular Oncology and Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Ligtenberg MA; Division of Molecular Oncology and Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Blankenstein S; Division of Surgical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
de Bruijn B; Division of Molecular Oncology and Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Frederick DT; Department of Surgical Oncology, Massachusetts General Hospital, Boston, MA, USA.
Kenski JCN; Division of Molecular Oncology and Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Parren M; Division of Molecular Oncology and Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Brüggemann M; Division of Molecular Oncology and Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Madu MF; Division of Surgical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Rozeman EA; Division of Molecular Oncology and Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Song JY; Division of Animal Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Horlings HM; Division of Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Blank CU; Division of Molecular Oncology and Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
van Akkooi ACJ; Division of Surgical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Flaherty KT; Department of Medical Oncology, Massachusetts General Hospital, Boston, MA, USA.
Boland GM; Department of Surgical Oncology, Massachusetts General Hospital, Boston, MA, USA.
Peeper DS; Division of Molecular Oncology and Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands. .
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Źródło :
Nature communications [Nat Commun] 2020 Aug 07; Vol. 11 (1), pp. 3946. Date of Electronic Publication: 2020 Aug 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents, Immunological/*pharmacology
Melanoma/*drug therapy
Nerve Tissue Proteins/*metabolism
Protein Kinase Inhibitors/*pharmacology
Receptors, Nerve Growth Factor/*metabolism
Skin Neoplasms/*drug therapy
T-Lymphocytes, Cytotoxic/*immunology
Animals ; Antineoplastic Agents, Immunological/therapeutic use ; Brain-Derived Neurotrophic Factor/antagonists & inhibitors ; Brain-Derived Neurotrophic Factor/metabolism ; Cell Line, Tumor ; Drug Resistance, Neoplasm/genetics ; Female ; Gene Expression Regulation, Neoplastic ; HEK293 Cells ; Humans ; Male ; Melanoma/genetics ; Melanoma/immunology ; Melanoma/pathology ; Mice ; Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors ; Nerve Tissue Proteins/antagonists & inhibitors ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; Programmed Cell Death 1 Receptor/immunology ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins B-raf/antagonists & inhibitors ; RNA-Seq ; Receptors, Nerve Growth Factor/antagonists & inhibitors ; Skin Neoplasms/genetics ; Skin Neoplasms/immunology ; Skin Neoplasms/pathology ; T-Lymphocytes, Cytotoxic/metabolism ; Tumor Escape/genetics ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology ; Xenograft Model Antitumor Assays
Czasopismo naukowe

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