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Wyszukujesz frazę ""Neurodegenerative Diseases"" wg kryterium: Temat


Tytuł :
The interplay between mitochondrial functionality and genome integrity in the prevention of human neurologic diseases.
Autorzy :
D'Errico M; Department of Environment and Health, Istituto Superiore di Sanità, Rome, Italy.
Parlanti E; Department of Environment and Health, Istituto Superiore di Sanità, Rome, Italy.
Pascucci B; Institute of Crystallography, Consiglio Nazionale Delle Ricerche, Rome, Italy.
Filomeni G; Redox Biology, Danish Cancer Society Research Center, Copenhagen, Denmark; Center for Healthy Aging, Copenhagen University, Copenhagen, Denmark; Department of Biology, University of Rome Tor Vergata, Rome, Italy.
Mastroberardino PG; Department of Molecular Genetics, Erasmus MC, Rotterdam, the Netherlands; IFOM- FIRC Institute of Molecular Oncology, Milan, Italy; Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
Dogliotti E; Department of Environment and Health, Istituto Superiore di Sanità, Rome, Italy. Electronic address: .
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Źródło :
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2021 Oct 15; Vol. 710, pp. 108977. Date of Electronic Publication: 2021 Jun 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Mitochondria/*genetics
Mitochondria/*metabolism
Neurodegenerative Diseases/*genetics
Neurodegenerative Diseases/*metabolism
DNA Damage ; DNA Repair ; DNA, Mitochondrial/genetics ; DNA, Mitochondrial/metabolism ; Genome, Human ; Genome, Mitochondrial ; Genomic Instability ; Humans ; Metabolic Networks and Pathways ; Mitochondrial Dynamics ; Mitophagy ; Models, Neurological ; Mutation ; Neurodegenerative Diseases/prevention & control ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
Small Molecule Improvement of Trafficking Defects in Models of Neurodegeneration.
Autorzy :
Hatstat AK; Department of Chemistry, Duke University, Durham, North Carolina 27708, United States.
Pupi MD; Department of Chemistry, Duke University, Durham, North Carolina 27708, United States.
Reinhart MC; Department of Chemistry, Duke University, Durham, North Carolina 27708, United States.
McCafferty DG; Department of Chemistry, Duke University, Durham, North Carolina 27708, United States.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2021 Nov 03; Vol. 12 (21), pp. 3972-3984. Date of Electronic Publication: 2021 Oct 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Endosomes*/metabolism
Neurodegenerative Diseases*/drug therapy
Neurodegenerative Diseases*/metabolism
Biological Transport ; Humans ; Protein Transport
Czasopismo naukowe
Tytuł :
In-frame deletion in canine PITRM1 is associated with a severe early-onset epilepsy, mitochondrial dysfunction and neurodegeneration.
Autorzy :
Hytönen MK; Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.; Folkhälsan Research Center, Helsinki, Finland.; Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland.
Sarviaho R; Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.; Folkhälsan Research Center, Helsinki, Finland.; Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland.
Jackson CB; Department of Biochemistry and Developmental Biology, University of Helsinki, Helsinki, Finland.
Syrjä P; Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland.
Jokinen T; Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.; Department of Equine and Small Animal Medicine, University of Helsinki, Helsinki, Finland.
Matiasek K; Faculty of Veterinary Medicine, Centre for Clinical Veterinary Medicine, LMU-Munich, Veterinärstrasse 13, 80539, Munich, Germany.
Rosati M; Faculty of Veterinary Medicine, Centre for Clinical Veterinary Medicine, LMU-Munich, Veterinärstrasse 13, 80539, Munich, Germany.
Dallabona C; Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parma, Italy.
Baruffini E; Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parma, Italy.
Quintero I; Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.; Folkhälsan Research Center, Helsinki, Finland.; Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland.
Arumilli M; Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.; Folkhälsan Research Center, Helsinki, Finland.; Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland.
Monteuuis G; Department of Biochemistry and Developmental Biology, University of Helsinki, Helsinki, Finland.
Donner J; Wisdom Health (Genoscoper Laboratories), Helsinki, Finland.
Anttila M; Finnish Food Authority, Helsinki, Finland.
Suomalainen A; Research Programs Unit, Stem Cells and Metabolism Research Program, University of Helsinki, Helsinki, Finland.
Bindoff LA; Department of Clinical Medicine (K1), University of Bergen, Bergen, Norway.; Department of Neurology, Neuro-SysMed, Haukeland University Hospital, Bergen, Norway.
Lohi H; Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland. .; Folkhälsan Research Center, Helsinki, Finland. .; Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland. .
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Źródło :
Human genetics [Hum Genet] 2021 Nov; Vol. 140 (11), pp. 1593-1609. Date of Electronic Publication: 2021 Apr 09.
Typ publikacji :
Journal Article
MeSH Terms :
Dog Diseases/*genetics
Epilepsy/*veterinary
Metalloendopeptidases/*genetics
Mitochondria/*metabolism
Neurodegenerative Diseases/*veterinary
Amyloid beta-Peptides/metabolism ; Animals ; Brain/enzymology ; Brain/metabolism ; Brain/pathology ; Dog Diseases/pathology ; Dogs ; Epilepsy/genetics ; Female ; Male ; Metalloendopeptidases/chemistry ; Metalloendopeptidases/metabolism ; Neurodegenerative Diseases/genetics ; Neurodegenerative Diseases/pathology ; Oxygen Consumption ; Pedigree ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/growth & development ; Saccharomyces cerevisiae/metabolism
Czasopismo naukowe
Tytuł :
Irisin injection mimics exercise effects on the brain proteome.
Autorzy :
Dehghan F; Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Zamani S; Department of Anatomical Sciences, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.; Department of Anatomical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Barreiro C; INBIOTEC (Instituto de Biotecnología de León), León, Spain.; Biochemistry and Molecular Biology Area, Department of Molecular Biology, University of León, Vegazana Campus, León, Spain.
Jami MS; Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.; QIANBIOTEC, Research and Development Center for Biotechnology, Isfahan, Iran.; Department of Neurology, David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, California, USA.
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Źródło :
The European journal of neuroscience [Eur J Neurosci] 2021 Nov; Vol. 54 (10), pp. 7422-7441. Date of Electronic Publication: 2021 Nov 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease*
Neurodegenerative Diseases*
Animals ; Brain ; Male ; Mice ; Proteome ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Czasopismo naukowe
Tytuł :
Protein Aggregation and Disaggregation in Cells and Development.
Autorzy :
Fassler JS; Department of Biology, University of Iowa, Iowa City, IA 52242, United States. Electronic address: .
Skuodas S; Department of Biology, University of Iowa, Iowa City, IA 52242, United States. Electronic address: https:.
Weeks DL; Department of Biochemistry, University of Iowa, Iowa City, IA 52242, United States.
Phillips BT; Department of Biology, University of Iowa, Iowa City, IA 52242, United States. Electronic address: https:.
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Źródło :
Journal of molecular biology [J Mol Biol] 2021 Oct 15; Vol. 433 (21), pp. 167215. Date of Electronic Publication: 2021 Aug 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms :
Protein Processing, Post-Translational*
Embryonic Development/*genetics
Gametogenesis/*genetics
Neurodegenerative Diseases/*genetics
Protein Aggregates/*genetics
Protein Aggregation, Pathological/*genetics
ATP-Binding Cassette Transporters/genetics ; ATP-Binding Cassette Transporters/metabolism ; Animals ; Cell Differentiation ; Cell Proliferation ; Eukaryotic Cells/cytology ; Eukaryotic Cells/metabolism ; Heat-Shock Proteins/genetics ; Heat-Shock Proteins/metabolism ; Humans ; Memory/physiology ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/pathology ; Nuclear Pore Complex Proteins/genetics ; Nuclear Pore Complex Proteins/metabolism ; Protein Aggregation, Pathological/metabolism ; Protein Aggregation, Pathological/pathology ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Neuroimmune multi-hit perspective of coronaviral infection.
Autorzy :
Hayley S; Department of Neuroscience, Carleton University, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada. .
Sun H; Department of Neuroscience, Carleton University, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada.
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Źródło :
Journal of neuroinflammation [J Neuroinflammation] 2021 Oct 13; Vol. 18 (1), pp. 231. Date of Electronic Publication: 2021 Oct 13.
Typ publikacji :
Journal Article; Review
MeSH Terms :
COVID-19/*immunology
Inflammation Mediators/*immunology
Mental Disorders/*immunology
Neurodegenerative Diseases/*immunology
Neuroimmunomodulation/*immunology
Animals ; Brain/immunology ; COVID-19/epidemiology ; Humans ; Immunotherapy/trends ; Mental Disorders/epidemiology ; Mental Disorders/therapy ; Neurodegenerative Diseases/epidemiology ; Neurodegenerative Diseases/therapy ; Stress, Psychological/epidemiology ; Stress, Psychological/immunology ; Stress, Psychological/therapy
Czasopismo naukowe
Tytuł :
Cellular Interactome of Mitochondrial Voltage-Dependent Anion Channels: Oligomerization and Channel (Mis)Regulation.
Autorzy :
Khan A; Molecular Biophysics Laboratory, Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal 462066, India.
Kuriachan G; Molecular Biophysics Laboratory, Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal 462066, India.
Mahalakshmi R; Molecular Biophysics Laboratory, Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal 462066, India.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2021 Oct 06; Vol. 12 (19), pp. 3497-3515. Date of Electronic Publication: 2021 Sep 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Neurodegenerative Diseases*/drug therapy
Neurodegenerative Diseases*/metabolism
Voltage-Dependent Anion Channels*/metabolism
Humans ; Mitochondria/metabolism ; Mitochondrial Membranes/metabolism ; Protein Isoforms/metabolism
Czasopismo naukowe
Tytuł :
Zebrafish and Medaka: Important Animal Models for Human Neurodegenerative Diseases.
Autorzy :
Wang J; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Donghu South Road 7#, Wuhan 430072, China.; College of Advanced Agriculture Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
Cao H; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Donghu South Road 7#, Wuhan 430072, China.; College of Advanced Agriculture Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 05; Vol. 22 (19). Date of Electronic Publication: 2021 Oct 05.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Disease Models, Animal*
Neurodegenerative Diseases/*pathology
Oryzias/*genetics
Zebrafish/*genetics
Animals ; Humans ; Neurodegenerative Diseases/etiology ; Neurodegenerative Diseases/metabolism ; Species Specificity
Czasopismo naukowe
Tytuł :
Neurodegenerative Diseases: A Multidisciplinary Approach.
Autorzy :
Marcos-Rabal P; Cellular Neurobiology and Molecular Chemistry of the Central Nervous System Group, Faculty of Medicine, Faculty of Pharmacy, and Regional Centre of Biomedical Research (CRIB), University of Castilla-La Mancha, Albacete, Spain.
González-Fuentes J; Cellular Neurobiology and Molecular Chemistry of the Central Nervous System Group, Faculty of Medicine, Faculty of Pharmacy, and Regional Centre of Biomedical Research (CRIB), University of Castilla-La Mancha, Albacete, Spain.
Castro-Vázquez L; Cellular Neurobiology and Molecular Chemistry of the Central Nervous System Group, Faculty of Medicine, Faculty of Pharmacy, and Regional Centre of Biomedical Research (CRIB), University of Castilla-La Mancha, Albacete, Spain.
Lozano MV; Cellular Neurobiology and Molecular Chemistry of the Central Nervous System Group, Faculty of Medicine, Faculty of Pharmacy, and Regional Centre of Biomedical Research (CRIB), University of Castilla-La Mancha, Albacete, Spain.
Rodríguez-Robledo V; Cellular Neurobiology and Molecular Chemistry of the Central Nervous System Group, Faculty of Medicine, Faculty of Pharmacy, and Regional Centre of Biomedical Research (CRIB), University of Castilla-La Mancha, Albacete, Spain.
Santander-Ortega MJ; Cellular Neurobiology and Molecular Chemistry of the Central Nervous System Group, Faculty of Medicine, Faculty of Pharmacy, and Regional Centre of Biomedical Research (CRIB), University of Castilla-La Mancha, Albacete, Spain.
Selva-Clemente J; Cellular Neurobiology and Molecular Chemistry of the Central Nervous System Group, Faculty of Medicine, Faculty of Pharmacy, and Regional Centre of Biomedical Research (CRIB), University of Castilla-La Mancha, Albacete, Spain.
Villaseca-González N; Cellular Neurobiology and Molecular Chemistry of the Central Nervous System Group, Faculty of Medicine, Faculty of Pharmacy, and Regional Centre of Biomedical Research (CRIB), University of Castilla-La Mancha, Albacete, Spain.
Del Mar Arroyo-Jiménez M; Cellular Neurobiology and Molecular Chemistry of the Central Nervous System Group, Faculty of Medicine, Faculty of Pharmacy, and Regional Centre of Biomedical Research (CRIB), University of Castilla-La Mancha, Albacete, Spain.
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Źródło :
Current pharmaceutical design [Curr Pharm Des] 2021 Oct 05; Vol. 27 (30), pp. 3305-3336.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Alzheimer Disease*
Neurodegenerative Diseases*/diagnosis
Neurodegenerative Diseases*/drug therapy
Aged ; Aging ; Animals ; Humans ; Models, Animal
Czasopismo naukowe
Tytuł :
Unusual Bioactive Compounds with Antioxidant Properties in Adjuvant Therapy Supporting Cognition Impairment in Age-Related Neurodegenerative Disorders.
Autorzy :
Cichon N; Biohazard Prevention Centre, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.
Dziedzic A; Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.
Gorniak L; Biohazard Prevention Centre, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.
Miller E; Department of Neurological Rehabilitation, Medical University of Lodz, Milionowa 14, 93-113 Lodz, Poland.
Bijak M; Biohazard Prevention Centre, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.
Starosta M; Department of Neurological Rehabilitation, Medical University of Lodz, Milionowa 14, 93-113 Lodz, Poland.
Saluk-Bijak J; Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 02; Vol. 22 (19). Date of Electronic Publication: 2021 Oct 02.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Aging*
Antioxidants/*therapeutic use
Biological Products/*therapeutic use
Cognition Disorders/*drug therapy
Cognition Disorders/*etiology
Neurodegenerative Diseases/*complications
Animals ; Antioxidants/pharmacology ; Biological Products/pharmacology ; Clinical Trials as Topic ; Cognition/drug effects ; Cognition Disorders/diagnosis ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/drug therapy ; Cognitive Dysfunction/etiology ; Dietary Supplements ; Drug Evaluation, Preclinical ; Humans ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/etiology ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Natural products attenuate PI3K/Akt/mTOR signaling pathway: A promising strategy in regulating neurodegeneration.
Autorzy :
Fakhri S; Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah 6734667149, Iran. Electronic address: .
Iranpanah A; Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address: .
Gravandi MM; Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address: .
Moradi SZ; Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah 6734667149, Iran; Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah 6734667149, Iran. Electronic address: .
Ranjbari M; Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address: .
Majnooni MB; Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address: .
Echeverría J; Departamento de Ciencias del Ambiente, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Chile. Electronic address: .
Qi Y; Purdue Quantum Science and Engineering Institute, Purdue University, West Lafayette, IN 47907, USA. Electronic address: .
Wang M; School of Biological Sciences, The University of Hong Kong, Hong Kong, PR China. Electronic address: .
Liao P; Department of Biochemistry, Purdue University, West Lafayette, IN 47907, USA. Electronic address: .
Farzaei MH; Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah 6734667149, Iran. Electronic address: .
Xiao J; International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang, China; Department of Analytical Chemistry and Food Science, Faculty of Food Science and Technology, University of Vigo - Ourense Campus, E-32004 Ourense, Spain. Electronic address: .
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Źródło :
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2021 Oct; Vol. 91, pp. 153664. Date of Electronic Publication: 2021 Jul 25.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Biological Products*/pharmacology
Neuroprotection*
Neurodegenerative Diseases/*metabolism
Signal Transduction/*drug effects
Humans ; Neurodegenerative Diseases/drug therapy ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł :
Plasma metabolites associated with biomarker evidence of neurodegeneration in cognitively normal older adults.
Autorzy :
Chatterjee P; Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, Australia.; School of Medical and Health Sciences, Edith Cowan University, Patricia Sarich Neuroscience Research Institute, Nedlands, WA, Australia.
Cheong YJ; Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, Australia.
Bhatnagar A; Department of Molecular Sciences, Macquarie University, North Ryde, NSW, Australia.
Goozee K; Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, Australia.; KaRa Institute of Neurological Disease, Sydney, NSW, Australia.; Clinical Research Department, Anglicare, Sydney, NSW, Australia.; School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, WA, Australia.
Wu Y; Department of Molecular Sciences, Macquarie University, North Ryde, NSW, Australia.
McKay M; Department of Molecular Sciences, Macquarie University, North Ryde, NSW, Australia.
Martins IJ; School of Medical and Health Sciences, Edith Cowan University, Patricia Sarich Neuroscience Research Institute, Nedlands, WA, Australia.
Lim WLF; School of Medical and Health Sciences, Edith Cowan University, Patricia Sarich Neuroscience Research Institute, Nedlands, WA, Australia.
Pedrini S; School of Medical and Health Sciences, Edith Cowan University, Patricia Sarich Neuroscience Research Institute, Nedlands, WA, Australia.
Tegg M; School of Medical and Health Sciences, Edith Cowan University, Patricia Sarich Neuroscience Research Institute, Nedlands, WA, Australia.
Villemagne VL; The Florey Institute of Neuroscience and Mental Health, University of Melbourne, VA, Australia.
Asih PR; School of Medical and Health Sciences, Edith Cowan University, Patricia Sarich Neuroscience Research Institute, Nedlands, WA, Australia.
Dave P; Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, Australia.; Clinical Research Department, Anglicare, Sydney, NSW, Australia.
Shah TM; Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, Australia.; School of Medical and Health Sciences, Edith Cowan University, Patricia Sarich Neuroscience Research Institute, Nedlands, WA, Australia.; Australian Alzheimer's Research Foundation, Nedlands, WA, Australia.
Dias CB; Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, Australia.
Fuller SJ; Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, Australia.
Hillebrandt H; Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, Australia.
Gupta S; Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, Australia.
Hone E; School of Medical and Health Sciences, Edith Cowan University, Patricia Sarich Neuroscience Research Institute, Nedlands, WA, Australia.
Taddei K; School of Medical and Health Sciences, Edith Cowan University, Patricia Sarich Neuroscience Research Institute, Nedlands, WA, Australia.; Australian Alzheimer's Research Foundation, Nedlands, WA, Australia.
Zetterberg H; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.; UK Dementia Research Institute at UCL, London, UK.
Blennow K; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Sohrabi HR; Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, Australia.; School of Medical and Health Sciences, Edith Cowan University, Patricia Sarich Neuroscience Research Institute, Nedlands, WA, Australia.; Australian Alzheimer's Research Foundation, Nedlands, WA, Australia.; Centre for Healthy Ageing, School of Psychology and Exercise Science, College of Science, Health, Engineering and Education, Murdoch University, Murdoch, WA, Australia.
Martins RN; Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, Australia.; School of Medical and Health Sciences, Edith Cowan University, Patricia Sarich Neuroscience Research Institute, Nedlands, WA, Australia.; KaRa Institute of Neurological Disease, Sydney, NSW, Australia.; School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, WA, Australia.; Australian Alzheimer's Research Foundation, Nedlands, WA, Australia.
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Źródło :
Journal of neurochemistry [J Neurochem] 2021 Oct; Vol. 159 (2), pp. 389-402. Date of Electronic Publication: 2020 Aug 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Neurodegenerative Diseases/*blood
Aged ; Aged, 80 and over ; Amyloid beta-Peptides/analysis ; Biogenic Amines/metabolism ; Biomarkers/analysis ; Cognition ; Cohort Studies ; Encephalitis/metabolism ; Female ; Humans ; Male ; Mass Spectrometry/methods ; Mitochondria/metabolism ; Neurodegenerative Diseases/diagnosis ; Neurodegenerative Diseases/psychology ; Neurofilament Proteins/analysis ; Neurotransmitter Agents/metabolism ; Nitric Oxide/metabolism ; Positron-Emission Tomography ; Prognosis
Czasopismo naukowe
Tytuł :
Systems modeling of metabolic dysregulation in neurodegenerative diseases.
Autorzy :
Baloni P; Institute for Systems Biology, Seattle, WA, USA.
Funk CC; Institute for Systems Biology, Seattle, WA, USA.
Readhead B; Onegevity, a Division of Thorne HealthTech, New York, NY, USA; Arizona State University-Banner Neurodegenerative Disease Research Center, Arizona State University, Tempe, AZ, USA.
Price ND; Institute for Systems Biology, Seattle, WA, USA; Onegevity, a Division of Thorne HealthTech, New York, NY, USA. Electronic address: .
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Źródło :
Current opinion in pharmacology [Curr Opin Pharmacol] 2021 Oct; Vol. 60, pp. 59-65. Date of Electronic Publication: 2021 Aug 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Huntington Disease*
Neurodegenerative Diseases*
Brain ; Humans ; Quality of Life ; Systems Biology
Czasopismo naukowe
Tytuł :
AMPK activators for the prevention and treatment of neurodegenerative diseases.
Autorzy :
Neumann NR; Department of Emergency Medicine, Yale School of Medicine, New Haven, CT, USA.
Thompson DC; Department of Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO, USA.
Vasiliou V; Department of Environmental Health Sciences, Yale School of Public Health, Yale School of Medicine, New Haven, CT, USA.
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Źródło :
Expert opinion on drug metabolism & toxicology [Expert Opin Drug Metab Toxicol] 2021 Oct; Vol. 17 (10), pp. 1199-1210.
Typ publikacji :
Journal Article; Review
MeSH Terms :
AMP-Activated Protein Kinases/*drug effects
Neurodegenerative Diseases/*drug therapy
Neuroprotective Agents/*pharmacology
AMP-Activated Protein Kinases/metabolism ; Animals ; Aspirin/pharmacology ; Enzyme Activators/pharmacology ; Humans ; Metformin/pharmacology ; Momordica charantia/chemistry ; Neurodegenerative Diseases/physiopathology
Czasopismo naukowe
Tytuł :
The neuroprotective potential of carotenoids in vitro and in vivo.
Autorzy :
Manochkumar J; School of Bio Sciences and Technology, VIT University, Vellore 632014, Tamil Nadu, India.
Doss CGP; School of Bio Sciences and Technology, VIT University, Vellore 632014, Tamil Nadu, India.
El-Seedi HR; Pharmacognosy, Department of Medicinal Chemistry, Uppsala University, Box 574, SE-75 123 Uppsala, Sweden; Department of Chemistry, Faculty of Science, Menoufia University, 32512 Shebin El-Koom, Egypt.
Efferth T; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Germany.
Ramamoorthy S; School of Bio Sciences and Technology, VIT University, Vellore 632014, Tamil Nadu, India. Electronic address: .
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Źródło :
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2021 Oct; Vol. 91, pp. 153676. Date of Electronic Publication: 2021 Jul 21.
Typ publikacji :
Journal Article; Systematic Review
MeSH Terms :
Carotenoids*/pharmacology
Neurodegenerative Diseases*/drug therapy
Neuroprotective Agents*/pharmacology
Antioxidants ; Humans ; Neuroprotection ; Oxidative Stress
Czasopismo naukowe
Tytuł :
The Relationship Between the Gut Microbiome and Neurodegenerative Diseases.
Autorzy :
Zhu X; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.; Research Units of Infectious Disease and Microecology, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Li B; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.; Research Units of Infectious Disease and Microecology, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Lou P; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.; Research Units of Infectious Disease and Microecology, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Dai T; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.; Research Units of Infectious Disease and Microecology, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Chen Y; The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Zhuge A; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.; Research Units of Infectious Disease and Microecology, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Yuan Y; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.; Research Units of Infectious Disease and Microecology, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Li L; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China. .; Research Units of Infectious Disease and Microecology, Chinese Academy of Medical Sciences, Beijing, 100730, China. .
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Źródło :
Neuroscience bulletin [Neurosci Bull] 2021 Oct; Vol. 37 (10), pp. 1510-1522. Date of Electronic Publication: 2021 Jul 03.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Alzheimer Disease*/therapy
Gastrointestinal Microbiome*
Microbiota*
Neurodegenerative Diseases*/therapy
Parkinson Disease*/therapy
Humans
Czasopismo naukowe
Tytuł :
Involvement of Microglia in Neurodegenerative Diseases: Beneficial Effects of Docosahexahenoic Acid (DHA) Supplied by Food or Combined with Nanoparticles.
Autorzy :
Charrière K; Centre Hospitalier Universitaire de Besançon, Centre d'Investigation Clinique, INSERM CIC 1431, 25030 Besançon, France.
Ghzaiel I; Team Bio-PeroxIL, 'Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism' (EA7270), Université de Bourgogne Franche-Comté, INSERM, UFR Sciences Vie Terre et Environnement, 21000 Dijon, France.
Lizard G; Team Bio-PeroxIL, 'Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism' (EA7270), Université de Bourgogne Franche-Comté, INSERM, UFR Sciences Vie Terre et Environnement, 21000 Dijon, France.
Vejux A; Team Bio-PeroxIL, 'Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism' (EA7270), Université de Bourgogne Franche-Comté, INSERM, UFR Sciences Vie Terre et Environnement, 21000 Dijon, France.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 30; Vol. 22 (19). Date of Electronic Publication: 2021 Sep 30.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Dietary Supplements*
Docosahexaenoic Acids/*administration & dosage
Drug Delivery Systems/*methods
Microglia/*metabolism
Nanoparticles/*chemistry
Neurodegenerative Diseases/*drug therapy
Neurodegenerative Diseases/*metabolism
Protective Agents/*administration & dosage
Animals ; Apoptosis/drug effects ; Blood-Brain Barrier/metabolism ; Disease Models, Animal ; Humans ; Inflammation/diet therapy ; Inflammation/drug therapy ; Inflammation/metabolism ; Neurodegenerative Diseases/diet therapy ; Oxidative Stress/drug effects ; Treatment Outcome
Czasopismo naukowe
Tytuł :
The Clp1 R140H mutation alters tRNA metabolism and mRNA 3' processing in mouse models of pontocerebellar hypoplasia.
Autorzy :
Monaghan CE; Department of Cellular and Molecular Medicine, Division of Biological Sciences, Section of Neurobiology, University of California San Diego, La Jolla, CA 92093.; HHMI, University of California San Diego, La Jolla, CA 92093.
Adamson SI; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06030.; Department of Genetics and Genome Sciences, Institute for Systems Genomics, UConn Health, Farmington, CT 06030.
Kapur M; Department of Cellular and Molecular Medicine, Division of Biological Sciences, Section of Neurobiology, University of California San Diego, La Jolla, CA 92093.; HHMI, University of California San Diego, La Jolla, CA 92093.
Chuang JH; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06030.; Department of Genetics and Genome Sciences, Institute for Systems Genomics, UConn Health, Farmington, CT 06030.
Ackerman SL; Department of Cellular and Molecular Medicine, Division of Biological Sciences, Section of Neurobiology, University of California San Diego, La Jolla, CA 92093; .; HHMI, University of California San Diego, La Jolla, CA 92093.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Sep 28; Vol. 118 (39).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Polyadenylation*
RNA Processing, Post-Transcriptional*
Cerebellar Diseases/*pathology
Neurodegenerative Diseases/*pathology
RNA, Messenger/*metabolism
RNA, Transfer/*metabolism
RNA-Binding Proteins/*physiology
Transcription Factors/*physiology
Animals ; Cerebellar Diseases/genetics ; Cerebellar Diseases/metabolism ; Disease Models, Animal ; Female ; Gene Expression Regulation ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mutation ; Neurodegenerative Diseases/genetics ; Neurodegenerative Diseases/metabolism ; RNA Precursors/genetics ; RNA Precursors/metabolism ; RNA, Messenger/genetics ; RNA, Transfer/genetics
SCR Disease Name :
Pontocerebellar Hypoplasia
Czasopismo naukowe
Tytuł :
Diosgenin Prevents Microglial Activation and Protects Dopaminergic Neurons from Lipopolysaccharide-Induced Neural Damage In Vitro and In Vivo.
Autorzy :
Lee SL; Department of Biological Science and Technology, China Medical University, Taichung 406040, Taiwan.
Tu SC; Department of Biological Science and Technology, China Medical University, Taichung 406040, Taiwan.; Department of Bioscience Technology, Chung Yuan Christian University, Taoyuan 320314, Taiwan.
Hsu MY; Department of Bioscience Technology, Chung Yuan Christian University, Taoyuan 320314, Taiwan.
Chin TY; Department of Bioscience Technology, Chung Yuan Christian University, Taoyuan 320314, Taiwan.; Department of Chemistry, Chung Yuan Christian University, Taoyuan 320314, Taiwan.; Center for Nano Technology, Chung Yuan Christian University, Taoyuan 320314, Taiwan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 26; Vol. 22 (19). Date of Electronic Publication: 2021 Sep 26.
Typ publikacji :
Journal Article
MeSH Terms :
Neurodegenerative Diseases*/chemically induced
Neurodegenerative Diseases*/metabolism
Neurodegenerative Diseases*/prevention & control
Diosgenin/*pharmacology
Dopaminergic Neurons/*metabolism
Lipopolysaccharides/*toxicity
Microglia/*metabolism
Neuroprotective Agents/*pharmacology
Animals ; MAP Kinase Signaling System/drug effects ; Male ; Neurites/metabolism ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
All Roads Lead to Rome: Different Molecular Players Converge to Common Toxic Pathways in Neurodegeneration.
Autorzy :
Argueti-Ostrovsky S; Department of Physiology and Cell Biology, Faculty of Health Sciences and The Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, P.O. Box 653, Beer Sheva 84105, Israel.
Alfahel L; Department of Physiology and Cell Biology, Faculty of Health Sciences and The Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, P.O. Box 653, Beer Sheva 84105, Israel.
Kahn J; Department of Physiology and Cell Biology, Faculty of Health Sciences and The Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, P.O. Box 653, Beer Sheva 84105, Israel.
Israelson A; Department of Physiology and Cell Biology, Faculty of Health Sciences and The Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, P.O. Box 653, Beer Sheva 84105, Israel.
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Źródło :
Cells [Cells] 2021 Sep 16; Vol. 10 (9). Date of Electronic Publication: 2021 Sep 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Active Transport, Cell Nucleus*
Endoplasmic Reticulum Stress*
Oxidative Stress*
Mitochondria/*pathology
Neurodegenerative Diseases/*pathology
Animals ; Humans ; Neurodegenerative Diseases/etiology
Czasopismo naukowe

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