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Tytuł:
An abundance of free regulatory (19 S ) proteasome particles regulates neuronal synapses.
Autorzy:
Sun C; Max Planck Institute for Brain Research, 60438 Frankfurt am Main, Germany.
Desch K; Max Planck Institute for Brain Research, 60438 Frankfurt am Main, Germany.
Nassim-Assir B; Max Planck Institute for Brain Research, 60438 Frankfurt am Main, Germany.
Giandomenico SL; Max Planck Institute for Brain Research, 60438 Frankfurt am Main, Germany.
Nemcova P; Max Planck Institute for Brain Research, 60438 Frankfurt am Main, Germany.
Langer JD; Max Planck Institute for Brain Research, 60438 Frankfurt am Main, Germany.; Max Planck Institute for Biophysics, 60438 Frankfurt am Main, Germany.
Schuman EM; Max Planck Institute for Brain Research, 60438 Frankfurt am Main, Germany.
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Źródło:
Science (New York, N.Y.) [Science] 2023 May 26; Vol. 380 (6647), pp. eadf2018. Date of Electronic Publication: 2023 May 26.
Typ publikacji:
Journal Article
MeSH Terms:
Neurons*/metabolism
Proteasome Endopeptidase Complex*/metabolism
Synapses*/metabolism
Animals ; Rats ; Proteolysis ; Ubiquitin/metabolism ; Lysine/metabolism ; Synaptic Transmission
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Proteasome cap particle regulates synapses.
Autorzy:
Türker F; Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Margolis SS; Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2023 May 26; Vol. 380 (6647), pp. 795-796. Date of Electronic Publication: 2023 May 25.
Typ publikacji:
Journal Article
MeSH Terms:
Proteasome Endopeptidase Complex*
Synapses*
Neurons
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Balancing neuronal circuits.
Autorzy:
Blumenstock S; Molecular Neurodegeneration Group, Max Planck Institute for Biological Intelligence, i.f., Martinsried, Germany.; Department of Molecules-Signaling-Development, Max Planck Institute for Biological Intelligence, i.f., Martinsried, Germany.; Department of Neurobiology, Center for Neural Circuits and Behavior, Department of Neurosciences, University of California, San Diego, CA, USA.
Dudanova I; Molecular Neurodegeneration Group, Max Planck Institute for Biological Intelligence, i.f., Martinsried, Germany.; Department of Molecules-Signaling-Development, Max Planck Institute for Biological Intelligence, i.f., Martinsried, Germany.; Center for Anatomy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
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Źródło:
Science (New York, N.Y.) [Science] 2022 Sep 23; Vol. 377 (6613), pp. 1383-1384. Date of Electronic Publication: 2022 Sep 22.
Typ publikacji:
Journal Article; Comment
MeSH Terms:
Dioxoles*/pharmacology
Dioxoles*/therapeutic use
Huntington Disease*/embryology
Huntington Disease*/genetics
Huntington Disease*/prevention & control
Nerve Net*/abnormalities
Nerve Net*/pathology
Piperidines*/pharmacology
Piperidines*/therapeutic use
Synapses*/drug effects
Synapses*/pathology
Aging ; Animals ; Mice ; Mice, Transgenic ; Neurons/drug effects ; Neurons/pathology ; Neurons/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Postnatal connectomic development of inhibition in mouse barrel cortex.
Autorzy:
Gour A; Department of Connectomics, Max Planck Institute for Brain Research, Frankfurt, Germany.
Boergens KM; Department of Connectomics, Max Planck Institute for Brain Research, Frankfurt, Germany.
Heike N; Department of Connectomics, Max Planck Institute for Brain Research, Frankfurt, Germany.
Hua Y; Department of Connectomics, Max Planck Institute for Brain Research, Frankfurt, Germany.
Laserstein P; Department of Connectomics, Max Planck Institute for Brain Research, Frankfurt, Germany.
Song K; Department of Connectomics, Max Planck Institute for Brain Research, Frankfurt, Germany.
Helmstaedter M; Department of Connectomics, Max Planck Institute for Brain Research, Frankfurt, Germany. .
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Źródło:
Science (New York, N.Y.) [Science] 2021 Jan 29; Vol. 371 (6528). Date of Electronic Publication: 2020 Dec 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Connectome*
GABAergic Neurons/*physiology
Interneurons/*physiology
Nerve Net/*growth & development
Somatosensory Cortex/*growth & development
Synapses/*physiology
Animals ; Axons/ultrastructure ; Datasets as Topic ; Dendrites/ultrastructure ; GABAergic Neurons/ultrastructure ; Imaging, Three-Dimensional/methods ; Interneurons/ultrastructure ; Mice ; Microscopy, Electron/methods ; Nerve Net/ultrastructure ; Somatosensory Cortex/ultrastructure ; Synapses/ultrastructure
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Local connectivity and synaptic dynamics in mouse and human neocortex.
Autorzy:
Campagnola L; Allen Institute for Brain Science, Seattle, WA, USA.
Seeman SC; Allen Institute for Brain Science, Seattle, WA, USA.
Chartrand T; Allen Institute for Brain Science, Seattle, WA, USA.
Kim L; Allen Institute for Brain Science, Seattle, WA, USA.
Hoggarth A; Allen Institute for Brain Science, Seattle, WA, USA.
Gamlin C; Allen Institute for Brain Science, Seattle, WA, USA.
Ito S; Allen Institute for Brain Science, Seattle, WA, USA.
Trinh J; Allen Institute for Brain Science, Seattle, WA, USA.
Davoudian P; Allen Institute for Brain Science, Seattle, WA, USA.
Radaelli C; Allen Institute for Brain Science, Seattle, WA, USA.
Kim MH; Allen Institute for Brain Science, Seattle, WA, USA.
Hage T; Allen Institute for Brain Science, Seattle, WA, USA.
Braun T; Byte Physics, Berlin, Germany.
Alfiler L; Allen Institute for Brain Science, Seattle, WA, USA.
Andrade J; Allen Institute for Brain Science, Seattle, WA, USA.
Bohn P; Allen Institute for Brain Science, Seattle, WA, USA.
Dalley R; Allen Institute for Brain Science, Seattle, WA, USA.
Henry A; Allen Institute for Brain Science, Seattle, WA, USA.
Kebede S; Allen Institute for Brain Science, Seattle, WA, USA.
Alice M; Allen Institute for Brain Science, Seattle, WA, USA.
Sandman D; Allen Institute for Brain Science, Seattle, WA, USA.
Williams G; Allen Institute for Brain Science, Seattle, WA, USA.
Larsen R; Allen Institute for Brain Science, Seattle, WA, USA.
Teeter C; Allen Institute for Brain Science, Seattle, WA, USA.
Daigle TL; Allen Institute for Brain Science, Seattle, WA, USA.
Berry K; Allen Institute for Brain Science, Seattle, WA, USA.
Dotson N; Allen Institute for Brain Science, Seattle, WA, USA.
Enstrom R; Allen Institute for Brain Science, Seattle, WA, USA.
Gorham M; Allen Institute for Brain Science, Seattle, WA, USA.
Hupp M; Allen Institute for Brain Science, Seattle, WA, USA.
Dingman Lee S; Allen Institute for Brain Science, Seattle, WA, USA.
Ngo K; Allen Institute for Brain Science, Seattle, WA, USA.
Nicovich PR; Allen Institute for Brain Science, Seattle, WA, USA.
Potekhina L; Allen Institute for Brain Science, Seattle, WA, USA.
Ransford S; Allen Institute for Brain Science, Seattle, WA, USA.
Gary A; Allen Institute for Brain Science, Seattle, WA, USA.
Goldy J; Allen Institute for Brain Science, Seattle, WA, USA.
McMillen D; Allen Institute for Brain Science, Seattle, WA, USA.
Pham T; Allen Institute for Brain Science, Seattle, WA, USA.
Tieu M; Allen Institute for Brain Science, Seattle, WA, USA.
Siverts L; Allen Institute for Brain Science, Seattle, WA, USA.
Walker M; Allen Institute for Brain Science, Seattle, WA, USA.
Farrell C; Allen Institute for Brain Science, Seattle, WA, USA.
Schroedter M; Allen Institute for Brain Science, Seattle, WA, USA.
Slaughterbeck C; Allen Institute for Brain Science, Seattle, WA, USA.
Cobb C; The Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, WA, USA.
Ellenbogen R; Department of Neurological Surgery, University of Washington, Seattle, WA, USA.
Gwinn RP; Epilepsy Surgery and Functional Neurosurgery, Swedish Neuroscience Institute, Seattle, WA, USA.
Keene CD; Department of Pathology, University of Washington, Seattle, WA, USA.
Ko AL; Department of Neurological Surgery, University of Washington, Seattle, WA, USA.; Regional Epilepsy Center at Harborview Medical Center, Seattle, WA, USA.
Ojemann JG; Department of Neurological Surgery, University of Washington, Seattle, WA, USA.; Regional Epilepsy Center at Harborview Medical Center, Seattle, WA, USA.
Silbergeld DL; Department of Neurological Surgery, University of Washington, Seattle, WA, USA.
Carey D; Allen Institute for Brain Science, Seattle, WA, USA.
Casper T; Allen Institute for Brain Science, Seattle, WA, USA.
Crichton K; Allen Institute for Brain Science, Seattle, WA, USA.
Clark M; Allen Institute for Brain Science, Seattle, WA, USA.
Dee N; Allen Institute for Brain Science, Seattle, WA, USA.
Ellingwood L; Allen Institute for Brain Science, Seattle, WA, USA.
Gloe J; Allen Institute for Brain Science, Seattle, WA, USA.
Kroll M; Allen Institute for Brain Science, Seattle, WA, USA.
Sulc J; Allen Institute for Brain Science, Seattle, WA, USA.
Tung H; Allen Institute for Brain Science, Seattle, WA, USA.
Wadhwani K; Allen Institute for Brain Science, Seattle, WA, USA.
Brouner K; Allen Institute for Brain Science, Seattle, WA, USA.
Egdorf T; Allen Institute for Brain Science, Seattle, WA, USA.
Maxwell M; Allen Institute for Brain Science, Seattle, WA, USA.
McGraw M; Allen Institute for Brain Science, Seattle, WA, USA.
Pom CA; Allen Institute for Brain Science, Seattle, WA, USA.
Ruiz A; Allen Institute for Brain Science, Seattle, WA, USA.
Bomben J; Allen Institute for Brain Science, Seattle, WA, USA.
Feng D; Allen Institute for Brain Science, Seattle, WA, USA.
Hejazinia N; Allen Institute for Brain Science, Seattle, WA, USA.
Shi S; Allen Institute for Brain Science, Seattle, WA, USA.
Szafer A; Allen Institute for Brain Science, Seattle, WA, USA.
Wakeman W; Allen Institute for Brain Science, Seattle, WA, USA.
Phillips J; Allen Institute for Brain Science, Seattle, WA, USA.
Bernard A; Allen Institute for Brain Science, Seattle, WA, USA.
Esposito L; Allen Institute for Brain Science, Seattle, WA, USA.
D'Orazi FD; Allen Institute for Brain Science, Seattle, WA, USA.
Sunkin S; Allen Institute for Brain Science, Seattle, WA, USA.
Smith K; Allen Institute for Brain Science, Seattle, WA, USA.
Tasic B; Allen Institute for Brain Science, Seattle, WA, USA.
Arkhipov A; Allen Institute for Brain Science, Seattle, WA, USA.
Sorensen S; Allen Institute for Brain Science, Seattle, WA, USA.
Lein E; Allen Institute for Brain Science, Seattle, WA, USA.
Koch C; Allen Institute for Brain Science, Seattle, WA, USA.
Murphy G; Allen Institute for Brain Science, Seattle, WA, USA.
Zeng H; Allen Institute for Brain Science, Seattle, WA, USA.
Jarsky T; Allen Institute for Brain Science, Seattle, WA, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2022 Mar 11; Vol. 375 (6585), pp. eabj5861. Date of Electronic Publication: 2022 Mar 11.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Neural Pathways*
Synaptic Transmission*
Neocortex/*physiology
Neurons/*physiology
Synapses/*physiology
Adult ; Animals ; Datasets as Topic ; Excitatory Postsynaptic Potentials ; Female ; Humans ; Inhibitory Postsynaptic Potentials ; Male ; Mice ; Mice, Transgenic ; Models, Neurological ; Neocortex/cytology ; Temporal Lobe/cytology ; Temporal Lobe/physiology ; Visual Cortex/cytology ; Visual Cortex/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Convergence of adenosine and GABA signaling for synapse stabilization during development.
Autorzy:
Gomez-Castro F; INSERM UMR-S 1270, Sorbonne Université, Institut du Fer à Moulin, Paris, France.
Zappettini S; Aix Marseille Université, INSERM, INS, Institut de Neurosciences des Systèmes, Marseille, France.
Pressey JC; INSERM UMR-S 1270, Sorbonne Université, Institut du Fer à Moulin, Paris, France.; Department of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3G5, Canada.
Silva CG; Aix Marseille Université, INSERM, INS, Institut de Neurosciences des Systèmes, Marseille, France.; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.
Russeau M; INSERM UMR-S 1270, Sorbonne Université, Institut du Fer à Moulin, Paris, France.
Gervasi N; INSERM UMR-S 1270, Sorbonne Université, Institut du Fer à Moulin, Paris, France.; Center for Interdisciplinary Research in Biology, College de France, INSERM U1050, CNRS UMR7241, Labex Memolife, Paris, France.
Figueiredo M; Institute of Pharmacology and Toxicology, University of Zürich, 8057 Zürich, Switzerland.
Montmasson C; INSERM UMR-S 1270, Sorbonne Université, Institut du Fer à Moulin, Paris, France.
Renner M; INSERM UMR-S 1270, Sorbonne Université, Institut du Fer à Moulin, Paris, France.
Canas PM; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.
Gonçalves FQ; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.
Alçada-Morais S; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.
Szabó E; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.
Rodrigues RJ; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.
Agostinho P; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.; Faculty of Medicine, University of Coimbra, 3004-504 Coimbra, Portugal.
Tomé AR; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.; Department of Life Sciences, University of Coimbra, 3000-456 Coimbra, Portugal.
Caillol G; Aix Marseille Université, CNRS, INP UMR7051, NeuroCyto, Marseille, France.
Thoumine O; Université Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS, UMR 5297, Bordeaux, France.
Nicol X; Sorbonne Université, Inserm, CNRS, Institut de la Vision, Paris, France.
Leterrier C; Aix Marseille Université, CNRS, INP UMR7051, NeuroCyto, Marseille, France.
Lujan R; Synaptic Structure Laboratory, Instituto de Investigación en Discapacidades Neurológicas (IDINE), Departamento Ciencias Médicas, Facultad de Medicina, Universidad Castilla-La Mancha, Campus Biosanitario, 02008 Albacete, Spain.
Tyagarajan SK; Institute of Pharmacology and Toxicology, University of Zürich, 8057 Zürich, Switzerland.
Cunha RA; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.; Faculty of Medicine, University of Coimbra, 3004-504 Coimbra, Portugal.
Esclapez M; Aix Marseille Université, INSERM, INS, Institut de Neurosciences des Systèmes, Marseille, France.
Bernard C; Aix Marseille Université, INSERM, INS, Institut de Neurosciences des Systèmes, Marseille, France.
Lévi S; INSERM UMR-S 1270, Sorbonne Université, Institut du Fer à Moulin, Paris, France.
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Źródło:
Science (New York, N.Y.) [Science] 2021 Nov 05; Vol. 374 (6568), pp. eabk2055. Date of Electronic Publication: 2021 Nov 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Signal Transduction*
Adenosine/*metabolism
Hippocampus/*growth & development
Neurons/*physiology
Receptor, Adenosine A2A/*metabolism
Synapses/*physiology
gamma-Aminobutyric Acid/*metabolism
Adenosine A2 Receptor Antagonists ; Adenosine Triphosphate/metabolism ; Animals ; Calcium/metabolism ; Cognition ; Cyclic AMP/metabolism ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Hippocampus/metabolism ; Male ; Membrane Proteins/metabolism ; Mice ; Nerve Tissue Proteins ; Phosphorylation ; Receptor, Adenosine A2A/genetics ; Receptors, GABA-A/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Architectures of neuronal circuits.
Autorzy:
Luo L; Department of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2021 Sep 03; Vol. 373 (6559), pp. eabg7285. Date of Electronic Publication: 2021 Sep 03.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Electronic Data Processing*
Nerve Net/*ultrastructure
Neurons/*ultrastructure
Synapses/*ultrastructure
Animals ; Artificial Intelligence ; Brain/ultrastructure ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Microglia modulate neurodegeneration in Alzheimer's and Parkinson's diseases.
Autorzy:
Bartels T; UK Dementia Research Institute, Institute of Neurology, University College London, London WC1E 6BT, UK.
De Schepper S; UK Dementia Research Institute, Institute of Neurology, University College London, London WC1E 6BT, UK.
Hong S; UK Dementia Research Institute, Institute of Neurology, University College London, London WC1E 6BT, UK. .
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Źródło:
Science (New York, N.Y.) [Science] 2020 Oct 02; Vol. 370 (6512), pp. 66-69.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Alzheimer Disease/*pathology
Amyloid/*metabolism
Macrophages/*metabolism
Microglia/*metabolism
Parkinson Disease/*pathology
Synapses/*pathology
Animals ; Cell Communication ; Humans ; Mice ; Neurons/metabolism ; Synaptosomes/pathology ; alpha-Synuclein/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A brainwide atlas of synapses across the mouse life span.
Autorzy:
Cizeron M; Genes to Cognition Program, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.; Institut NeuroMyoGène, Université de Lyon, Université Claude Bernard Lyon 1, CNRS UMR-5310, INSERM U-1217, 69008 Lyon, France.
Qiu Z; Genes to Cognition Program, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.
Koniaris B; Genes to Cognition Program, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.; School of Computing, Edinburgh Napier University, Edinburgh EH10 5DT, UK.
Gokhale R; Genes to Cognition Program, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.
Komiyama NH; Genes to Cognition Program, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.; Simons Initiative for the Developing Brain (SIDB), Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK.
Fransén E; Department of Computational Science and Technology, School of Electrical Engineering and Computer Science, KTH Royal Institute of Technology, 10044 Stockholm, Sweden.; Science for Life Laboratory, KTH Royal Institute of Technology, SE-171 65 Solna, Sweden.
Grant SGN; Genes to Cognition Program, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK. .; Simons Initiative for the Developing Brain (SIDB), Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK.
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Źródło:
Science (New York, N.Y.) [Science] 2020 Jul 17; Vol. 369 (6501), pp. 270-275. Date of Electronic Publication: 2020 Jun 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Brain*/physiology
Brain*/ultrastructure
Synapses*/physiology
Animals ; Atlases as Topic ; Datasets as Topic ; Longevity ; Male ; Mice ; Neurons/physiology ; Synaptosomes/physiology ; Synaptosomes/ultrastructure
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Local protein synthesis is a ubiquitous feature of neuronal pre- and postsynaptic compartments.
Autorzy:
Hafner AS; Max Planck Institute for Brain Research, Frankfurt, Germany.
Donlin-Asp PG; Max Planck Institute for Brain Research, Frankfurt, Germany.
Leitch B; Department of Anatomy, School of Biomedical Sciences and the Brain Health Research Centre, University of Otago, Dunedin, New Zealand.
Herzog E; Interdisciplinary Institute for Neuroscience, University of Bordeaux, UMR 5297, F-33000, Bordeaux, France.; Interdisciplinary Institute for Neuroscience, CNRS, UMR 5297, F-33000, Bordeaux, France.
Schuman EM; Max Planck Institute for Brain Research, Frankfurt, Germany. .
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Źródło:
Science (New York, N.Y.) [Science] 2019 May 17; Vol. 364 (6441).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Biosynthesis*
Neurons/*metabolism
Synapses/*metabolism
Animals ; Cells, Cultured ; Cerebral Cortex/cytology ; Cerebral Cortex/metabolism ; Dendrites/metabolism ; Mice ; Mice, Mutant Strains ; Neuronal Plasticity ; Pituitary Gland/cytology ; Pituitary Gland/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats ; Rats, Inbred Strains ; Ribosomes/metabolism ; Vesicular Glutamate Transport Protein 1/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Latrophilin GPCRs direct synapse specificity by coincident binding of FLRTs and teneurins.
Autorzy:
Sando R; Department of Molecular and Cellular Physiology and Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA 94305, USA.
Jiang X; Department of Molecular and Cellular Physiology and Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA 94305, USA.
Südhof TC; Department of Molecular and Cellular Physiology and Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA 94305, USA. .
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Źródło:
Science (New York, N.Y.) [Science] 2019 Feb 22; Vol. 363 (6429).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
CA1 Region, Hippocampal/*physiology
Membrane Proteins/*metabolism
Nerve Tissue Proteins/*metabolism
Neurons/*physiology
Receptors, G-Protein-Coupled/*physiology
Receptors, Peptide/*metabolism
Synapses/*physiology
Animals ; CA1 Region, Hippocampal/cytology ; HEK293 Cells ; Humans ; Membrane Glycoproteins ; Mice ; Mice, Knockout ; Protein Binding ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; Receptors, Peptide/genetics ; Synapses/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting.
Autorzy:
Awasthi A; Trans-synaptic Signaling Group, European Neuroscience Institute, 37077 Goettingen, Germany.
Ramachandran B; Trans-synaptic Signaling Group, European Neuroscience Institute, 37077 Goettingen, Germany.
Ahmed S; Trans-synaptic Signaling Group, European Neuroscience Institute, 37077 Goettingen, Germany.
Benito E; German Center for Neurodegenerative Disease, 37075 Goettingen, Germany.; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, 37075 Goettingen, Germany.
Shinoda Y; Trans-synaptic Signaling Group, European Neuroscience Institute, 37077 Goettingen, Germany.
Nitzan N; Trans-synaptic Signaling Group, European Neuroscience Institute, 37077 Goettingen, Germany.
Heukamp A; Trans-synaptic Signaling Group, European Neuroscience Institute, 37077 Goettingen, Germany.
Rannio S; Trans-synaptic Signaling Group, European Neuroscience Institute, 37077 Goettingen, Germany.
Martens H; Synaptic Systems GmbH, 37079 Goettingen, Germany.
Barth J; German Center for Neurodegenerative Disease, 37075 Goettingen, Germany.; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, 37075 Goettingen, Germany.
Burk K; Trans-synaptic Signaling Group, European Neuroscience Institute, 37077 Goettingen, Germany.
Wang YT; Brain Research Center and Department of Medicine, University of British Columbia, Vancouver, BC V6T2B5, Canada.
Fischer A; German Center for Neurodegenerative Disease, 37075 Goettingen, Germany.; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, 37075 Goettingen, Germany.
Dean C; Trans-synaptic Signaling Group, European Neuroscience Institute, 37077 Goettingen, Germany. .
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Źródło:
Science (New York, N.Y.) [Science] 2019 Jan 04; Vol. 363 (6422). Date of Electronic Publication: 2018 Dec 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Endocytosis*
Memory*
Receptors, AMPA/*physiology
Synapses/*physiology
Synaptotagmins/*physiology
Animals ; Calcium/physiology ; Cells, Cultured ; Female ; HEK293 Cells ; Hippocampus/cytology ; Hippocampus/physiology ; Humans ; Immunohistochemistry ; In Vitro Techniques ; Long-Term Potentiation ; Long-Term Synaptic Depression ; Male ; Maze Learning ; Mice ; Mice, Knockout ; Neurons/physiology ; Protein Transport ; Rats, Wistar ; Subcellular Fractions ; Synaptic Vesicles ; Synaptosomes ; Synaptotagmins/genetics ; Transfection
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A gut-brain neural circuit for nutrient sensory transduction.
Autorzy:
Kaelberer MM; Department of Medicine, Duke University, Durham, NC, USA.
Buchanan KL; School of Medicine, Duke University, Durham, USA, NC.
Klein ME; Department of Medicine, Duke University, Durham, NC, USA.
Barth BB; Department of Biomedical Engineering, Duke University, Durham, NC, USA.
Montoya MM; Department of Biomedical Engineering, Duke University, Durham, NC, USA.
Shen X; Department of Biomedical Engineering, Duke University, Durham, NC, USA.
Bohórquez DV; Department of Medicine, Duke University, Durham, NC, USA. .; Department of Neurobiology, Duke University, Durham, NC, USA.; Duke Institute for Brain Sciences, Duke University, Durham, NC, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2018 Sep 21; Vol. 361 (6408).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Synapses*
Brain Stem/*physiology
Enteroendocrine Cells/*metabolism
Intestine, Small/*cytology
Animals ; Electrophysiological Phenomena ; Enteroendocrine Cells/cytology ; Green Fluorescent Proteins/metabolism ; Intestine, Small/physiology ; Mice ; Neurons/cytology ; Signal Transduction ; Vagus Nerve/physiology ; Vesicular Glutamate Transport Protein 1/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Interregional synaptic maps among engram cells underlie memory formation.
Autorzy:
Choi JH; School of Biological Sciences, Seoul National University, Gwanak-gu, Seoul 08826, South Korea.
Sim SE; School of Biological Sciences, Seoul National University, Gwanak-gu, Seoul 08826, South Korea.
Kim JI; School of Biological Sciences, Seoul National University, Gwanak-gu, Seoul 08826, South Korea.
Choi DI; School of Biological Sciences, Seoul National University, Gwanak-gu, Seoul 08826, South Korea.
Oh J; School of Biological Sciences, Seoul National University, Gwanak-gu, Seoul 08826, South Korea.
Ye S; School of Biological Sciences, Seoul National University, Gwanak-gu, Seoul 08826, South Korea.
Lee J; School of Biological Sciences, Seoul National University, Gwanak-gu, Seoul 08826, South Korea.
Kim T; School of Biological Sciences, Seoul National University, Gwanak-gu, Seoul 08826, South Korea.
Ko HG; School of Biological Sciences, Seoul National University, Gwanak-gu, Seoul 08826, South Korea.
Lim CS; School of Biological Sciences, Seoul National University, Gwanak-gu, Seoul 08826, South Korea.
Kaang BK; School of Biological Sciences, Seoul National University, Gwanak-gu, Seoul 08826, South Korea. .
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Źródło:
Science (New York, N.Y.) [Science] 2018 Apr 27; Vol. 360 (6387), pp. 430-435.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
CA1 Region, Hippocampal/*physiology
CA3 Region, Hippocampal/*physiology
Memory/*physiology
Neurons/*physiology
Synapses/*physiology
Animals ; CA1 Region, Hippocampal/cytology ; CA3 Region, Hippocampal/cytology ; Conditioning, Classical ; Fear ; Green Fluorescent Proteins/analysis ; HEK293 Cells ; Humans ; Long-Term Potentiation ; Male ; Mice, Inbred C57BL ; Neuroimaging/methods ; Neuronal Plasticity
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The molecular biology of memory storage: a dialogue between genes and synapses.
Autorzy:
Kandel ER; Howard Hughes Medical Institute, Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2001 Nov 02; Vol. 294 (5544), pp. 1030-8.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review
MeSH Terms:
Gene Expression Regulation*
Hippocampus/*physiology
Memory/*physiology
Neurons/*physiology
Synapses/*physiology
Animals ; Aplysia/physiology ; Learning/physiology ; Long-Term Potentiation ; Neural Pathways/physiology ; Neurons, Afferent/physiology ; Neurotransmitter Agents/metabolism ; Second Messenger Systems/physiology ; Signal Transduction ; Synaptic Transmission ; Transcription, Genetic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Homer1a drives homeostatic scaling-down of excitatory synapses during sleep.
Autorzy:
Diering GH; Solomon Snyder Department of Neuroscience, Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD, USA.
Nirujogi RS; Department of Biological Chemistry, Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA.
Roth RH; Solomon Snyder Department of Neuroscience, Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD, USA.
Worley PF; Solomon Snyder Department of Neuroscience, Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD, USA.
Pandey A; Department of Biological Chemistry, Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA.
Huganir RL; Solomon Snyder Department of Neuroscience, Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD, USA. .
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Źródło:
Science (New York, N.Y.) [Science] 2017 Feb 03; Vol. 355 (6324), pp. 511-515. Date of Electronic Publication: 2017 Feb 02.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Homer Scaffolding Proteins/*physiology
Sleep/*physiology
Synapses/*physiology
Wakefulness/*physiology
Adenosine/pharmacology ; Animals ; Cell Count ; Cells, Cultured ; Cognition/physiology ; Homeostasis ; Homer Scaffolding Proteins/genetics ; Learning/physiology ; Mice ; Neurons/physiology ; Neurons/ultrastructure ; Norepinephrine/pharmacology ; Prosencephalon/cytology ; Prosencephalon/physiology ; Rats ; Rats, Sprague-Dawley ; Receptor, Metabotropic Glutamate 5/metabolism ; Receptors, Metabotropic Glutamate/metabolism ; Sleep/drug effects ; Wakefulness/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Control of neuronal synapse specification by a highly dedicated alternative splicing program.
Autorzy:
Traunmüller L; Biozentrum, University of Basel Klingelbergstrasse 50-70, 4056 Basel, Switzerland.
Gomez AM; Biozentrum, University of Basel Klingelbergstrasse 50-70, 4056 Basel, Switzerland.
Nguyen TM; Biozentrum, University of Basel Klingelbergstrasse 50-70, 4056 Basel, Switzerland.
Scheiffele P; Biozentrum, University of Basel Klingelbergstrasse 50-70, 4056 Basel, Switzerland .
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Źródło:
Science (New York, N.Y.) [Science] 2016 May 20; Vol. 352 (6288), pp. 982-6. Date of Electronic Publication: 2016 May 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alternative Splicing*
Glutamic Acid/*physiology
Neurons/*physiology
RNA-Binding Proteins/*physiology
Synapses/*physiology
Animals ; Behavior, Animal ; Calcium-Binding Proteins ; Exons ; Genome-Wide Association Study ; Hippocampus/cytology ; Hippocampus/physiology ; Mice ; Mice, Knockout ; Neural Cell Adhesion Molecules/genetics ; Neural Cell Adhesion Molecules/physiology ; Neuronal Plasticity/genetics ; Neuronal Plasticity/physiology ; RNA, Messenger/metabolism ; RNA-Binding Proteins/genetics ; Sequence Deletion ; Synaptic Transmission/genetics ; Synaptic Transmission/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Synaptic depression and cortical gain control.
Autorzy:
Abbott LF; Volen Center, Brandeis University, Waltham, MA 02254, USA.
Varela JA
Sen K
Nelson SB
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Źródło:
Science (New York, N.Y.) [Science] 1997 Jan 10; Vol. 275 (5297), pp. 220-4.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Models, Neurological*
Synaptic Transmission*
Neurons/*physiology
Synapses/*physiology
Action Potentials ; Animals ; Electric Stimulation ; In Vitro Techniques ; Neuronal Plasticity ; Neurons, Afferent/physiology ; Rats ; Visual Cortex/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Sequential synaptic excitation and inhibition shape readiness discharge for voluntary behavior.
Autorzy:
Kagaya K; Department of Biological Sciences, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan. />Takahata M
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Źródło:
Science (New York, N.Y.) [Science] 2011 Apr 15; Vol. 332 (6027), pp. 365-8.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Astacoidea/*physiology
Interneurons/*physiology
Locomotion/*physiology
Motor Activity/*physiology
Neurons/*physiology
Synapses/*physiology
Action Potentials ; Animals ; Axons/physiology ; Brain/physiology ; Electromyography ; Female ; Ganglia, Invertebrate/physiology ; Male ; Membrane Potentials ; Muscles/physiology ; Neural Inhibition ; Neural Pathways ; Neurons/cytology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 311

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