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Wyszukujesz frazę ""Neurons/metabolism"" wg kryterium: Temat


Tytuł :
Protein synthesis levels are increased in a subset of individuals with fragile X syndrome
Autorzy :
Randi J Hagerman
Sébastien Jacquemont
Laura Pacini
Baltazar Gomez-Mancilla
Giulia Cencelli
Marwa Eldeeb
Claudia Bagni
Rob Willemsen
Yunsheng He
Aia E. Jønch
Giorgia Pedini
Fabrizio Gasparini
Laura D'Andrea
Izabela Rozenberg
Flora Tassone
Pokaż więcej
Temat :
Articles
Corrigendum
Genetics(clinical)
Genetics
Molecular Biology
General Medicine
Protein biosynthesis
Biology
Fragile X syndrome
medicine.disease
medicine
FMR1
Intellectual disability
Downregulation and upregulation
Biomarker (medicine)
Internal medicine
medicine.medical_specialty
Endocrinology
Disease
Autism spectrum disorder
Adolescent
Adult
Aged
Animals
Autism Spectrum Disorder/genetics
Autism Spectrum Disorder/physiopathology
Child
Disease Models, Animal
Female
Fibroblasts/metabolism
Fibroblasts/pathology
Fragile X Mental Retardation Protein/biosynthesis
Fragile X Mental Retardation Protein/genetics
Fragile X Syndrome/genetics
Fragile X Syndrome/physiopathology
Hippocampus/metabolism
Hippocampus/physiopathology
Humans
Male
Mice
Mice, Knockout
Middle Aged
Neurons/metabolism
Neurons/pathology
Young Adult
Autism Spectrum Disorder
Fibroblasts
Fragile X Mental Retardation Protein
Fragile X Syndrome
Hippocampus
Neurons
Settore BIO/13
Knockout
Disease Models
Animal
Biological Sciences
Medical and Health Sciences
Genetics & Heredity
congenital, hereditary, and neonatal diseases and abnormalities
Źródło :
Human Molecular Genetics, vol. 27, no. 21, pp. 3825
Human Molecular Genetics, 27(12), 2039-2051
Human Molecular Genetics
Human molecular genetics, vol. 27, no. 12, pp. 2039-2051
Human Molecular Genetics, 27(21)
Jacquemont, S, Pacini, L, Jønch, A E, Cencelli, G, Rozenberg, I, He, Y, D'Andrea, L, Pedini, G, Eldeeb, M, Willemsen, R, Gasparini, F, Tassone, F, Hagerman, R, Gomez-Mancilla, B & Bagni, C 2018, ' Protein synthesis levels are increased in a subset of individuals with Fragile X syndrome ', Human Molecular Genetics, vol. 27, no. 12, pp. 2039–2051 . https://doi.org/10.1093/hmg/ddy099
Human molecular genetics, vol 27, iss 12
Human molecular genetics, vol 27, iss 21
Opis pliku :
application/pdf
Dostępność :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51f22e11b6b6db3f38b4f481bd98ed9
http://doc.rero.ch/record/332107/files/HMG_27_12_2039.pdf
Tytuł :
Induced Pluripotent Stem Cells to Understand Mucopolysaccharidosis. I: Demonstration of a Migration Defect in Neural Precursors
Autorzy :
Matthias R. Baumgartner
Adama Sidibé
Sten Ilmjärv
Silvin Lito
Bernhard Wehrle-Haller
Antoine Marteyn
Patricie Burda
Karl-Heinz Krause
Pokaż więcej
Temat :
Article
induced pluripotent stem cells
neuronal differentiation
disease modelling
mucopolysaccharidosis I
neural migration
neurite outgrowth
lcsh:Biology (General)
lcsh:QH301-705.5
ddc:616.07
ddc:612
Cell Differentiation/genetics
Cell Movement/genetics
Cells
Cultured
Gene Expression/genetics
Glycosaminoglycans/genetics/metabolism
Humans
Iduronidase/genetics/metabolism
Induced Pluripotent Stem Cells/metabolism
Lysosomes/genetics/metabolism
Mucopolysaccharidosis I/genetics/metabolism
Mutation/genetics
Neurons/metabolism
Phenotype
Medical Clinic
610 Medicine & health
General Medicine
Allele
Mucopolysaccharidosis I
Neurodegeneration
medicine.disease
medicine
Cell biology
Induced pluripotent stem cell
Gene expression
Biology
Gene
Mucopolysaccharidosis
Źródło :
Cells
Cells, Vol 9, Iss 2593, p 2593 (2020)
Cells, Vol. 9, No 12 (2020) P. 2593
Lito, Silvin; Sidibe, Adama; Ilmjarv, Sten; Burda, Patricie; Baumgartner, Matthias; Wehrle-Haller, Bernhard; Krause, Karl-Heinz; Marteyn, Antoine (2020). Induced pluripotent stem cells to understand mucopolysaccharidosis. I: demonstration of a migration defect in neural precursors. Cells, 9(12):2593.
Volume 9
Issue 12
Opis pliku :
application/pdf
Dostępność :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5339141b498e3433fdc221a55707396
http://europepmc.org/articles/PMC7761689
Tytuł :
Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node
Autorzy :
Li, Ning
Kalyanasundaram, Anuradha
Hansen, Brian J.
Artiga, Esthela J.
Sharma, Roshan
Abudulwahed, Suhaib H.
Helfrich, Katelynn M.
Rozenberg, Galina
Wu, Pei-Jung
Zakharkin, Stanislav
Gyorke, Sandor
Janssen, Paul ML.
Whitson, Bryan A.
Mokadam, Nahush A.
Biesiadecki, Brandon J.
Accornero, Federica
Hummel, John D.
Mohler, Peter J.
Dobrzynski, Halina
Zhao, Jichao
Fedorov, Vadim V.
Pokaż więcej
Temat :
lcsh:Science
lcsh:Q
Science
Action Potentials/physiology
Adult
Aged
Alcoholism/genetics
Arrhythmias, Cardiac/genetics
Chronic Disease
Computer Simulation
Female
Heart Atria/metabolism
Heart Conduction System/metabolism
Heart Failure/genetics
Humans
Male
Middle Aged
Models, Cardiovascular
Neurons/metabolism
Optical Imaging
Protein Subunits/metabolism
RNA, Messenger/genetics
Sinoatrial Node/metabolism
Sodium Channels/genetics
Stress, Physiological
Young Adult
Article
Sodium channels
Imaging
Arrhythmias
General Physics and Astronomy
General Biochemistry, Genetics and Molecular Biology
General Chemistry
Heart failure
medicine.disease
medicine
Optical mapping
Atrium (architecture)
Sinoatrial node
medicine.anatomical_structure
Blockade
business.industry
business
Neuroscience
Sodium channel
Reentry
Electrical conduction system of the heart
Źródło :
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Li, N, Kalyanasundaram, A, Hansen, B J, Artiga, E J, Sharma, R, Abudulwahed, S H, Helfrich, K M, Rozenberg, G, Wu, P-J, Zakharkin, S, Gyorke, S, Janssen, P, Whitson, B A, Mokadam, N A, Biesiadecki, B J, Accornero, F, Hummel, J D, Jichao Zhao, J, Mohler, P J, Dobrzynski, H & Fedorov, V V 2020, ' Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node ', Nature Communications, vol. 11, no. 1, 512, pp. 512 . https://doi.org/10.1038/s41467-019-14039-8
Nature Communications
Dostępność :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4a93e9c4e29410729a773cc9c04368c
http://link.springer.com/article/10.1038/s41467-019-14039-8
Tytuł :
Single-cell transcriptomic atlas of the human retina identifies cell types associated with age-related macular degeneration
Autorzy :
Menon, Madhvi
Mohammadi, Shahin
Davila-Velderrain, Jose
Goods, Brittany A.
Cadwell, Tanina D.
Xing, Yu
Stemmer-Rachamimov, Anat
Shalek, Alex K.
Love, John Christopher
Kellis, Manolis
Hafler, Brian P.
Pokaż więcej
Temat :
Science
Article
Retina
Macular degeneration
General Physics and Astronomy
General Biochemistry, Genetics and Molecular Biology
General Chemistry
Cell type
Computational biology
Genome-wide association study
Gene expression profiling
Single-cell analysis
medicine.anatomical_structure
medicine
Genetic association
Biology
medicine.disease
Transcriptome
lcsh:Science
lcsh:Q
Amacrine Cells/metabolism
Astrocytes/metabolism
Blood Vessels
Ependymoglial Cells/metabolism
Gene Expression
Gene Expression Profiling
Genetic Predisposition to Disease
High-Throughput Nucleotide Sequencing
Humans
Macular Degeneration/genetics
Microglia/metabolism
Neuroglia/metabolism
Retina/cytology
Retinal Bipolar Cells/metabolism
Retinal Cone Photoreceptor Cells/metabolism
Retinal Ganglion Cells/metabolism
Retinal Horizontal Cells/metabolism
Retinal Neurons/metabolism
Retinal Rod Photoreceptor Cells/metabolism
Retinal Vessels/cytology
Sequence Analysis, RNA
Single-Cell Analysis
sense organs
genetic structures
eye diseases
Źródło :
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Nature Communications
Menon, M, Mohammadi, S, Davila-Velderrain, J, Goods, B A, Cadwell, T D, Xing, Y, Stemmer-Rachamimov, A, Shalek, A K, Love, J C, Kellis, M & Hafler, B P 2019, ' Single-cell transcriptomic atlas of the human retina identifies cell types associated with age-related macular degeneration ', Nature Communications, vol. 10, no. 1, pp. 4902 . https://doi.org/10.1038/s41467-019-12780-8
Dostępność :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed2b98c8de6da04883f066af379fc0b
https://doaj.org/article/569a863f6cff4674a0253494b0beaa87
Tytuł :
An Improved Adeno-Associated Virus Vector for Neurological Correction of the Mouse Model of Mucopolysaccharidosis IIIA
Autorzy :
Jessica T. Taylor
Nuria Palomar
Els Henckaerts
Helen Parker
Rebecca J. Holley
Brian W. Bigger
Anna L. Gray
Olivier Danos
R. Michael Linden
Hélène F.E. Gleitz
Michaël Hocquemiller
Aiyin Liao
Claire O'Leary
Leticia Agúndez
Amir Saam Youshani
Pokaż więcej
Temat :
Genetics
Molecular Biology
Molecular Medicine
Sulfatase-Modifying Factor 1
Gene expression
Pharmacology
Genetic enhancement
Viral vector
Mucopolysaccharidosis
medicine.disease
medicine
Heparan sulfate
chemistry.chemical_compound
chemistry
Lysosomal storage disease
Adeno-associated virus
medicine.disease_cause
business.industry
business
Animals
Biomarkers
Corpus Striatum/metabolism
Cytokines/metabolism
Dependovirus/genetics
Disease Models, Animal
Enzyme Activation
Fluorescent Antibody Technique
Gene Expression
Gene Order
Genetic Therapy/adverse effects
Genetic Vectors/administration & dosage
Hydrolases/genetics
Mice
Mucopolysaccharidosis III/genetics
Neurons/metabolism
Organ Specificity/genetics
Transduction, Genetic
Transgenes
Treatment Outcome
Źródło :
Gray, A L, O'Leary, C, Liao, A, Agúndez, L, Youshani, A S, Gleitz, H F, Parker, H, Taylor, J T, Danos, O, Hocquemiller, M, Palomar, N, Linden, R M, Henckaerts, E, Holley, R J & Bigger, B W 2019, ' An Improved Adeno-Associated Virus Vector for Neurological Correction of the Mouse Model of Mucopolysaccharidosis IIIA ', Human Gene Therapy, vol. 30, no. 9, pp. 1052-1066 . https://doi.org/10.1089/hum.2018.189
Dostępność :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::228c8b1a0791d243a26d6d7bed43929a
https://www.liebertpub.com/doi/full-xml/10.1089/hum.2018.189
Tytuł :
Single cell transcriptome analysis of developing arcuate nucleus neurons uncovers their key developmental regulators
Autorzy :
Huisman, Christian
Cho, Hyeyoung
Brock, Olivier
Lim, Su Jeong
Youn, Sung Min
Park, Younjung
Kim, Sangsoo
Lee, Soo-Kyung
Delogu, Alessio
Lee, Jae W.
Pokaż więcej
Temat :
lcsh:Science
lcsh:Q
Animals
Arcuate Nucleus of Hypothalamus/cytology
Forkhead Transcription Factors/genetics
Gene Expression Profiling
Gene Expression Regulation, Developmental
Growth Hormone-Releasing Hormone/metabolism
Kisspeptins/metabolism
Mice
Mice, Knockout
Neurogenesis/genetics
Neurons/metabolism
Repressor Proteins/genetics
SOXB2 Transcription Factors/genetics
Single-Cell Analysis
Article
Developmental biology
Neuroscience
General Physics and Astronomy
General Biochemistry, Genetics and Molecular Biology
General Chemistry
Nucleus
medicine.anatomical_structure
medicine
Embryonic stem cell
FOXP2
Regulation of gene expression
Biology
Transcription factor
Cell biology
Arc (geometry)
Single-cell analysis
SOX14
Science
nervous system
Źródło :
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Huisman, C, Cho, H, Brock, O, Lim, S J, Youn, S M, Park, Y, Kim, S, Lee, S-K, Delogu, A & Lee, J W 2019, ' Single cell transcriptome analysis of developing arcuate nucleus neurons uncovers their key developmental regulators ', Nature Communications, vol. 10, no. 1, 3696, pp. 1-12 . https://doi.org/10.1038/s41467-019-11667-y
Nature Communications
Opis pliku :
application/pdf
Dostępność :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d2df2c7aa75fb836803b8ab93fb19d1
http://link.springer.com/article/10.1038/s41467-019-11667-y
Tytuł :
Oxidative stress and inflammation in a spectrum of epileptogenic cortical malformations: molecular insights into their interdependence
Autorzy :
Jackelien van Scheppingen
Peter C. van Rijen
Wim G.M. Spliet
Anatoly Korotkov
Erwin A. van Vliet
Marzia Perluigi
Till S. Zimmer
Annamaria Vezzani
Jasper J. Anink
Johannes C. Baayen
Eleonora Aronica
Floor E. Jansen
Angelika Mühlebner
James D. Mills
Andrea Arena
Anand M. Iyer
Sander Idema
Wim Van Hecke
Pokaż więcej
Temat :
Clinical Neurology
Pathology and Forensic Medicine
General Neuroscience
Inflammation
medicine.symptom
medicine
Pathology
medicine.medical_specialty
Cortical dysplasia
medicine.disease
business.industry
business
Cortical tubers
Neuroinflammation
Tuberous sclerosis
Hemimegalencephaly
Epilepsy
Immunohistochemistry
Journal Article
epilepsy
focal cortical dysplasia
hemimegalencephaly
tuberous sclerosis complex
inflammation
oxidative stress
Oxidative Stress/physiology
Humans
Middle Aged
Tuberous Sclerosis
Child
Preschool
Epilepsy/metabolism
Infant
Male
Malformations of Cortical Development/metabolism
Adult
Female
Drug Resistant Epilepsy/metabolism
Newborn
Cell Line
Malformations of Cortical Development
Group I
Seizures/physiopathology
Signal Transduction
Cerebral Cortex/metabolism
Inflammation/metabolism
Neurons/metabolism
Adolescent
NF-kappa B/metabolism
Brain/metabolism
Neuroscience(all)
Research Support
Non-U.S. Gov't
Research Articles
Child, Preschool
Infant, Newborn
Malformations of Cortical Development, Group I
Research Support, Non-U.S. Gov't
Źródło :
Brain Pathology
Brain Pathol
Brain pathology (Zurich, Switzerland), 29(3), 351. Wiley-Blackwell
Brain Pathology, 29(3), 351-365. Wiley-Blackwell
Brain pathology (Zurich, Switzerland), 29(3), 351-365. Wiley-Blackwell
Opis pliku :
text/plain; application/pdf
Dostępność :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a78ab6d3fbc13b4c45fce8d110deec78
Tytuł :
Characterization of transgenic mouse models targeting neuromodulatory systems reveals organizational principles of the dorsal raphe
Autorzy :
Cardozo Pinto, Daniel F.
Yang, Hongbin
Pollak Dorocic, Iskra
de Jong, Johannes W.
Han, Vivian J.
Peck, James R.
Zhu, Yichen
Liu, Christine
Beier, Kevin T.
Smidt, Marten P.
Lammel, Stephan
Pokaż więcej
Temat :
Animals
Dopaminergic Neurons/metabolism
Dorsal Raphe Nucleus/physiology
Mice
Transgenic
Models
Animal
Neural Pathways
Neurotransmitter Agents/genetics
Serotonergic Neurons/metabolism
Serotonin Plasma Membrane Transport Proteins/genetics
General Physics and Astronomy
General Biochemistry, Genetics and Molecular Biology
General Chemistry
Biological neural network
Glutamate receptor
Genetically modified mouse
Neuroscience
Dopamine
medicine.drug
medicine
Amygdala
medicine.anatomical_structure
Transgene
Dorsal raphe nucleus
5-HT receptor
Biology
Mice, Transgenic
Models, Animal
Neurotransmitter Agents
Serotonin Plasma Membrane Transport Proteins
Dopaminergic Neurons
Serotonergic Neurons
Dorsal Raphe Nucleus
Neurosciences
1.1 Normal biological development and functioning
Neurological
MD Multidisciplinary
Article
Neural circuits
lcsh:Science
lcsh:Q
Science
Źródło :
Nature Communications, 10:4633. Nature Publishing Group
Nature communications, vol 10, iss 1
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Opis pliku :
application/pdf
Dostępność :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f76106dc8bef4d818ad4a2daf1cbbd2

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