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Tytuł :
The biophysical basis of receptor tyrosine kinase ligand functional selectivity: Trk-B case study.
Autorzy :
Ahmed F; Department of Materials Science and Engineering, Johns Hopkins University, 3400 Charles Street, Baltimore, MD 21218, U.S.A.; Institute for NanoBioTechnology, Johns Hopkins University, 3400 Charles Street, Baltimore, MD 21218, U.S.A.
Paul MD; Institute for NanoBioTechnology, Johns Hopkins University, 3400 Charles Street, Baltimore, MD 21218, U.S.A.; Program in Molecular Biophysics, Johns Hopkins University, 3400 Charles Street, Baltimore, MD 21218, U.S.A.
Hristova K; Department of Materials Science and Engineering, Johns Hopkins University, 3400 Charles Street, Baltimore, MD 21218, U.S.A.; Institute for NanoBioTechnology, Johns Hopkins University, 3400 Charles Street, Baltimore, MD 21218, U.S.A.; Program in Molecular Biophysics, Johns Hopkins University, 3400 Charles Street, Baltimore, MD 21218, U.S.A.
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Źródło :
The Biochemical journal [Biochem J] 2020 Dec 11; Vol. 477 (23), pp. 4515-4526.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Protein Multimerization*
Brain-Derived Neurotrophic Factor/*metabolism
Cell Membrane/*metabolism
Membrane Glycoproteins/*metabolism
Nerve Growth Factors/*metabolism
Neurotrophin 3/*metabolism
Receptor, trkB/*metabolism
Brain-Derived Neurotrophic Factor/genetics ; Cell Membrane/genetics ; Fluorescence Resonance Energy Transfer ; HEK293 Cells ; Humans ; Ligands ; Membrane Glycoproteins/genetics ; Nerve Growth Factors/genetics ; Neurotrophin 3/genetics ; Receptor, trkB/genetics
Czasopismo naukowe
Tytuł :
A highly potent and safe pyrrolopyridine-based allosteric HIV-1 integrase inhibitor targeting host LEDGF/p75-integrase interaction site.
Autorzy :
Maehigashi, Tatsuya (AUTHOR)
Ahn, Seohyun (AUTHOR)
Kim, Uk-Il (AUTHOR)
Lindenberger, Jared (AUTHOR)
Oo, Adrian (AUTHOR)
Koneru, Pratibha C. (AUTHOR)
Mahboubi, Bijan (AUTHOR)
Engelman, Alan N. (AUTHOR)
Kvaratskhelia, Mamuka (AUTHOR)
Kim, Kyungjin (AUTHOR)
Kim, Baek (AUTHOR)
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Źródło :
PLoS Pathogens. 7/22/2021, Vol. 17 Issue 7, p1-20. 20p.
Czasopismo naukowe
Tytuł :
Therapeutic Development in Charcot Marie Tooth Type 1 Disease.
Autorzy :
Miniou P; InFlectis BioScience SAS, 21 Rue La Noue Bras de Fer, 44200 Nantes, France.
Fontes M; Centre de recherche en CardioVasculaire et Nutrition, Aix-Marseille Université, INRA 1260-INSERM 1263, 13005 Marseille, France.; Repositioning SAS, 8 Rue Napoleon, 20210 Calenzana, France.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 23; Vol. 22 (13). Date of Electronic Publication: 2021 Jun 23.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Exercise Therapy*
Charcot-Marie-Tooth Disease/*therapy
Gangliosides/*administration & dosage
Neurotrophin 3/*therapeutic use
Animals ; Humans
Czasopismo naukowe
Tytuł :
Effect of Aloe vera on the Expression of Nerve Factors, p75 and TrkA Receptors in the Hippocampus of Diabetic Rats.
Autorzy :
Mahabady, Mahmood Khaksary
Tapebur, Mohammad Bahrami
Mazaheri, Yazdan
Tabandeh, Mohammad Reza
Tabatabaei, Seyed Reza Fatemi
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Alternatywny tytuł :
Efecto del Aloe vera sobre la Expresión de Factores de Crecimiento Nervioso, Receptores p75 y TrkA en el Hipocampo de Ratas Diabéticas.
Źródło :
International Journal of Morphology. abr2021, Vol. 39 Issue 2, p577-586. 10p.
Czasopismo naukowe
Tytuł :
Exercise-Induced Plasticity in Signaling Pathways Involved in Motor Recovery after Spinal Cord Injury.
Autorzy :
Bilchak JN; Marion Murray Spinal Cord Research Center, Department of Neurobiology and Anatomy, Drexel University, Philadelphia, PA 19129, USA.
Caron G; Marion Murray Spinal Cord Research Center, Department of Neurobiology and Anatomy, Drexel University, Philadelphia, PA 19129, USA.
Côté MP; Marion Murray Spinal Cord Research Center, Department of Neurobiology and Anatomy, Drexel University, Philadelphia, PA 19129, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 04; Vol. 22 (9). Date of Electronic Publication: 2021 May 04.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Exercise*
Gene Expression Regulation*
Nerve Regeneration/*genetics
Neuronal Plasticity/*genetics
Recovery of Function/*genetics
Spinal Cord Injuries/*genetics
Animals ; Brain-Derived Neurotrophic Factor/genetics ; Brain-Derived Neurotrophic Factor/metabolism ; Glial Cell Line-Derived Neurotrophic Factor/genetics ; Glial Cell Line-Derived Neurotrophic Factor/metabolism ; Humans ; Neurotrophin 3/genetics ; Neurotrophin 3/metabolism ; Quality of Life ; Receptor, Serotonin, 5-HT2A/genetics ; Receptor, Serotonin, 5-HT2A/metabolism ; Serotonin/metabolism ; Signal Transduction ; Spinal Cord/metabolism ; Spinal Cord/pathology ; Spinal Cord Injuries/metabolism ; Spinal Cord Injuries/pathology ; Spinal Cord Injuries/rehabilitation ; Symporters/genetics ; Symporters/metabolism
Czasopismo naukowe
Tytuł :
Neurotrophin-3 modulates synaptic transmission.
Autorzy :
Hernández-Echeagaray E; Laboratorio de Neurofisiología del desarrollo y la neurodegeneración, Unidad de Investigación en Biomedicina, Facultad de Estudios Superiores, Iztacala, Universidad Nacional Autónoma de México, Los Reyes Iztacala, México. Electronic address: .
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Źródło :
Vitamins and hormones [Vitam Horm] 2020; Vol. 114, pp. 71-89. Date of Electronic Publication: 2020 Jul 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation/*physiology
Neurotrophin 3/*metabolism
Synaptic Transmission/*physiology
Animals ; Humans ; Neurotrophin 3/genetics ; Receptor, trkC/genetics ; Receptor, trkC/metabolism
Czasopismo naukowe
Tytuł :
Dorsal Amygdala Neurotrophin-3 Decreases Anxious Temperament in Primates.
Autorzy :
Fox AS; Department of Psychology and the California National Primate Research Center, University of California, Davis, Davis, California. Electronic address: .
Souaiaia T; Department of Cell Biology, Downstate Medical Center, State University of New York, Brooklyn, New York.
Oler JA; Department of Psychiatry and the HealthEmotions Research Institute, University of Wisconsin-Madison, Madison, Wisconsin.
Kovner R; Department of Psychiatry and the HealthEmotions Research Institute, University of Wisconsin-Madison, Madison, Wisconsin.
Kim JMH; Department of Cell Biology, Downstate Medical Center, State University of New York, Brooklyn, New York.
Nguyen J; Department of Cell Biology, Downstate Medical Center, State University of New York, Brooklyn, New York.
French DA; Department of Psychiatry and the HealthEmotions Research Institute, University of Wisconsin-Madison, Madison, Wisconsin.
Riedel MK; Department of Psychiatry and the HealthEmotions Research Institute, University of Wisconsin-Madison, Madison, Wisconsin.
Fekete EM; Department of Psychiatry and the HealthEmotions Research Institute, University of Wisconsin-Madison, Madison, Wisconsin.
Rabska MR; Department of Psychiatry and the HealthEmotions Research Institute, University of Wisconsin-Madison, Madison, Wisconsin.
Olsen ME; Department of Psychiatry and the HealthEmotions Research Institute, University of Wisconsin-Madison, Madison, Wisconsin.
Brodsky EK; Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin.
Alexander AL; Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin.
Block WF; Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin.
Roseboom PH; Department of Psychiatry and the HealthEmotions Research Institute, University of Wisconsin-Madison, Madison, Wisconsin.
Knowles JA; Department of Cell Biology, Downstate Medical Center, State University of New York, Brooklyn, New York.
Kalin NH; Department of Psychiatry and the HealthEmotions Research Institute, University of Wisconsin-Madison, Madison, Wisconsin. Electronic address: .
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Źródło :
Biological psychiatry [Biol Psychiatry] 2019 Dec 15; Vol. 86 (12), pp. 881-889. Date of Electronic Publication: 2019 Jul 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Amygdala/*metabolism
Anxiety/*metabolism
Neurotrophin 3/*metabolism
Receptor, trkC/*metabolism
Animals ; Anxiety/genetics ; Disease Models, Animal ; Gene Expression ; Macaca mulatta ; Male ; Neurotrophin 3/genetics
Czasopismo naukowe
Tytuł :
Protection from noise-induced cochlear synaptopathy by virally mediated overexpression of NT3.
Autorzy :
Hashimoto K; Department of Otolaryngology-Head and Neck Surgery, Harvard Medical School, Boston, MA, USA.; Eaton-Peabody Laboratories, Massachusetts Eye & Ear, Boston, MA, USA.; Department of Otorhinolaryngology-Head and Neck Surgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Hickman TT; Department of Otolaryngology-Head and Neck Surgery, Harvard Medical School, Boston, MA, USA. .; Eaton-Peabody Laboratories, Massachusetts Eye & Ear, Boston, MA, USA. .
Suzuki J; Department of Otolaryngology-Head and Neck Surgery, Harvard Medical School, Boston, MA, USA.; Eaton-Peabody Laboratories, Massachusetts Eye & Ear, Boston, MA, USA.; Department of Otorhinolaryngology-Head and Neck Surgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Ji L; Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI, USA.; Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
Kohrman DC; Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI, USA.; Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
Corfas G; Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI, USA.; Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
Liberman MC; Department of Otolaryngology-Head and Neck Surgery, Harvard Medical School, Boston, MA, USA.; Eaton-Peabody Laboratories, Massachusetts Eye & Ear, Boston, MA, USA.
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Źródło :
Scientific reports [Sci Rep] 2019 Oct 25; Vol. 9 (1), pp. 15362. Date of Electronic Publication: 2019 Oct 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Noise*
Cochlea/*pathology
Dependovirus/*metabolism
Neurotrophin 3/*metabolism
Synapses/*pathology
Animals ; Auditory Threshold ; Cochlea/physiopathology ; Evoked Potentials, Auditory, Brain Stem ; Green Fluorescent Proteins/metabolism ; Hair Cells, Auditory, Inner/metabolism ; Hair Cells, Auditory, Inner/pathology ; Hair Cells, Auditory, Outer/metabolism ; Hair Cells, Auditory, Outer/pathology ; Male ; Mice, Inbred C57BL ; Mice, Inbred CBA ; Neurotrophin 3/genetics ; Otoacoustic Emissions, Spontaneous ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Synapses/metabolism
Czasopismo naukowe
Tytuł :
Differential Clinical Significance of Neurotrophin-3 Expression according to MYCN Amplification and TrkC Expression in Neuroblastoma.
Autorzy :
Seo E; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Kim JS; Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.; Department of Health Sciences and Technology, Sungkyunkwan University, Samsung Advanced Institute for Health Sciences & Technology, Seoul, Korea.
Ma YE; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Cho HW; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Ju HY; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Lee SH; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Lee JW; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Yoo KH; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Sung KW; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. .
Koo HH; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
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Źródło :
Journal of Korean medical science [J Korean Med Sci] 2019 Oct 14; Vol. 34 (39), pp. e254. Date of Electronic Publication: 2019 Oct 14.
Typ publikacji :
Journal Article
MeSH Terms :
N-Myc Proto-Oncogene Protein/*metabolism
Neuroblastoma/*diagnosis
Neurotrophin 3/*metabolism
Receptor, trkC/*metabolism
Adolescent ; Antineoplastic Agents/therapeutic use ; Child ; Child, Preschool ; Female ; Humans ; Immunohistochemistry ; Infant ; Infant, Newborn ; Male ; N-Myc Proto-Oncogene Protein/genetics ; Neoplasm Staging ; Neuroblastoma/drug therapy ; Neuroblastoma/pathology ; Neurotrophin 3/genetics ; Prognosis ; Progression-Free Survival ; Proportional Hazards Models ; Real-Time Polymerase Chain Reaction ; Receptor, trkC/genetics
Czasopismo naukowe
Tytuł :
Copper complexes of synthetic peptides mimicking neurotrophin-3 enhance neurite outgrowth and CREB phosphorylation.
Autorzy :
Naletova I; Department of Chemical Sciences, University of Catania, Viale A. Doria 6, 95125 Catania, Italy. .
Grasso GI; Department of Chemical Sciences, University of Catania, Viale A. Doria 6, 95125 Catania, Italy. .
Satriano C; Department of Chemical Sciences, University of Catania, Viale A. Doria 6, 95125 Catania, Italy. .
Travaglia A; Department of Chemical Sciences, University of Catania, Viale A. Doria 6, 95125 Catania, Italy. .
La Mendola D; Department of Pharmacy, University of Pisa, Via Bonanno Pisano 6, 56126 Pisa, Italy. .
Arena G; Department of Chemical Sciences, University of Catania, Viale A. Doria 6, 95125 Catania, Italy. .
Rizzarelli E; Department of Chemical Sciences, University of Catania, Viale A. Doria 6, 95125 Catania, Italy. and Institute of Crystallography UOS Catania, National Council of Research (IC-CNR), Via Paolo Gaifami 18, I-95126 Catania, Italy.
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Źródło :
Metallomics : integrated biometal science [Metallomics] 2019 Sep 01; Vol. 11 (9), pp. 1567-1578. Date of Electronic Publication: 2019 Sep 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Coordination Complexes/*pharmacology
Copper/*pharmacology
Cyclic AMP Response Element-Binding Protein/*metabolism
Neuronal Outgrowth/*drug effects
Neurotrophin 3/*pharmacology
Peptides/*pharmacology
Cell Line ; Coordination Complexes/chemistry ; Copper/chemistry ; Humans ; Neurotrophin 3/chemistry ; Peptides/chemistry ; Phosphorylation/drug effects
Czasopismo naukowe
Tytuł :
Peripheral blood neurotrophic factor levels in children with autism spectrum disorder: a meta-analysis.
Autorzy :
Liu SH; Center On Translational Neuroscience, College of Life and Environmental Sciences, Minzu University of China, 27 South Zhongguancun Avenue, Zhongguancun South St, Haidian District, Beijing, 100081, China.
Shi XJ; Center On Translational Neuroscience, College of Life and Environmental Sciences, Minzu University of China, 27 South Zhongguancun Avenue, Zhongguancun South St, Haidian District, Beijing, 100081, China.
Fan FC; Center On Translational Neuroscience, College of Life and Environmental Sciences, Minzu University of China, 27 South Zhongguancun Avenue, Zhongguancun South St, Haidian District, Beijing, 100081, China.
Cheng Y; Center On Translational Neuroscience, College of Life and Environmental Sciences, Minzu University of China, 27 South Zhongguancun Avenue, Zhongguancun South St, Haidian District, Beijing, 100081, China. .
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Źródło :
Scientific reports [Sci Rep] 2021 Jan 08; Vol. 11 (1), pp. 15. Date of Electronic Publication: 2021 Jan 08.
Typ publikacji :
Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Systematic Review
MeSH Terms :
Autism Spectrum Disorder/*blood
Nerve Growth Factors/*blood
Biomarkers/blood ; Brain-Derived Neurotrophic Factor/blood ; Case-Control Studies ; Child ; Female ; Humans ; Male ; Nerve Growth Factor/blood ; Neurotrophin 3/blood ; Vascular Endothelial Growth Factor A/blood
Czasopismo naukowe
Tytuł :
Is neurotrophin-3 (NT-3): a potential therapeutic target for depression and anxiety?
Autorzy :
de Miranda AS; Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais , Belo Horizonte, Brazil.; Laboratório de Neurobiologia, Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais , Belo Horizonte, Brazil.
de Barros JLVM; Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais , Belo Horizonte, Brazil.
Teixeira AL; Neuropsychiatry Program, Department of Psychiatry & Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston , Houston, TX, Brazil.
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Źródło :
Expert opinion on therapeutic targets [Expert Opin Ther Targets] 2020 Dec; Vol. 24 (12), pp. 1225-1238. Date of Electronic Publication: 2020 Nov 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Anxiety Disorders/*drug therapy
Depressive Disorder, Major/*drug therapy
Neurotrophin 3/*metabolism
Animals ; Anxiety Disorders/physiopathology ; Depressive Disorder, Major/physiopathology ; Humans ; MicroRNAs/genetics ; Molecular Targeted Therapy ; Mood Disorders/drug therapy ; Mood Disorders/physiopathology ; Receptor, trkC/genetics
Czasopismo naukowe
Tytuł :
Neurotrophin-3 stimulates stem Leydig cell proliferation during regeneration in rats.
Autorzy :
Yu Y; Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Li Z; Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Ma F; Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Chen Q; Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Lin L; Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Xu Q; Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Li Y; Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Xin X; Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Pan P; Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Huang T; Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Wang Y; Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Fei Q; Reproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Ge RS; Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
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Źródło :
Journal of cellular and molecular medicine [J Cell Mol Med] 2020 Dec; Vol. 24 (23), pp. 13679-13689. Date of Electronic Publication: 2020 Oct 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Leydig Cells/*drug effects
Leydig Cells/*metabolism
Neurotrophin 3/*pharmacology
Regeneration/*drug effects
Stem Cells/*drug effects
Stem Cells/*metabolism
Animals ; Biomarkers ; Cell Differentiation/drug effects ; Cell Proliferation/drug effects ; Fluorescent Antibody Technique ; Follicle Stimulating Hormone/blood ; Gene Expression ; Immunohistochemistry ; Luteinizing Hormone/blood ; Male ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; TOR Serine-Threonine Kinases/metabolism ; Testosterone/metabolism
Czasopismo naukowe
Tytuł :
Histological and functional outcomes in a rat model of hemisected spinal cord with sustained VEGF/NT-3 release from tissue-engineered grafts.
Autorzy :
Xu ZX; Department of Spinal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, P.R. China.
Zhang LQ; Department of Spinal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, P.R. China.
Zhou YN; Department of Spinal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, P.R. China.
Chen XM; Department of Spinal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, P.R. China.
Xu WH; Department of Spinal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, P.R. China.
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Źródło :
Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2020 Dec; Vol. 48 (1), pp. 362-376.
Typ publikacji :
Journal Article; Video-Audio Media
MeSH Terms :
Mesenchymal Stem Cells*/metabolism
Mesenchymal Stem Cells*/pathology
Nerve Tissue*/metabolism
Nerve Tissue*/pathology
Nerve Tissue*/transplantation
Spinal Cord Injuries*/metabolism
Spinal Cord Injuries*/pathology
Spinal Cord Injuries*/therapy
Spinal Cord Regeneration*
Tissue Engineering*
Neurotrophin 3/*metabolism
Vascular Endothelial Growth Factor A/*metabolism
Animals ; Disease Models, Animal ; Male ; Rats ; Rats, Sprague-Dawley ; Tissue Scaffolds/chemistry
Czasopismo naukowe
Tytuł :
Neurotrophin-3 acts on the endothelial-mesenchymal transition of heterotopic ossification in rats.
Autorzy :
Zhang J; Department of Orthopedics, The Third Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong, PR China.; Academy of Orthopedics, Guangdong Province, Guangzhou, Guangdong, PR China.
Wang L; Department of Orthopedics, The Third Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong, PR China.; Academy of Orthopedics, Guangdong Province, Guangzhou, Guangdong, PR China.
Cao H; Department of Orthopedics, The Third Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong, PR China.; Academy of Orthopedics, Guangdong Province, Guangzhou, Guangdong, PR China.
Chen N; Department of Plastic Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, PR China.
Yan B; Department of Orthopedics, The Third Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong, PR China.; Academy of Orthopedics, Guangdong Province, Guangzhou, Guangdong, PR China.
Ao X; Department of Orthopedics, The Third Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong, PR China.; Academy of Orthopedics, Guangdong Province, Guangzhou, Guangdong, PR China.
Zhao H; Department of Orthopedics, The Third Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong, PR China.; Academy of Orthopedics, Guangdong Province, Guangzhou, Guangdong, PR China.
Chu J; Department of Orthopedics, The Third Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong, PR China.; Academy of Orthopedics, Guangdong Province, Guangzhou, Guangdong, PR China.
Huang M; Department of Orthopedics, The Third Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong, PR China.; Academy of Orthopedics, Guangdong Province, Guangzhou, Guangdong, PR China.
Zhang Z; Department of Orthopedics, The Third Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong, PR China.; Academy of Orthopedics, Guangdong Province, Guangzhou, Guangdong, PR China.
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Źródło :
Journal of cellular and molecular medicine [J Cell Mol Med] 2019 Apr; Vol. 23 (4), pp. 2595-2609. Date of Electronic Publication: 2019 Jan 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chondrogenesis/*genetics
Endothelial Cells/*drug effects
Epithelial-Mesenchymal Transition/*drug effects
Mesenchymal Stem Cells/*drug effects
Neurotrophin 3/*genetics
Ossification, Heterotopic/*genetics
Osteogenesis/*genetics
Actins/genetics ; Actins/metabolism ; Animals ; Antigens, Surface/genetics ; Antigens, Surface/metabolism ; Cadherins/genetics ; Cadherins/metabolism ; Calcium-Binding Proteins/genetics ; Calcium-Binding Proteins/metabolism ; Core Binding Factor Alpha 1 Subunit/genetics ; Core Binding Factor Alpha 1 Subunit/metabolism ; Endothelial Cells/cytology ; Endothelial Cells/metabolism ; Epithelial-Mesenchymal Transition/genetics ; Female ; Gene Expression Regulation ; Hyaluronan Receptors/genetics ; Hyaluronan Receptors/metabolism ; Male ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/metabolism ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Neurotrophin 3/metabolism ; Neurotrophin 3/pharmacology ; Ossification, Heterotopic/metabolism ; Ossification, Heterotopic/pathology ; Osteocalcin/genetics ; Osteocalcin/metabolism ; Primary Cell Culture ; Protein Kinase Inhibitors/pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptor, trkC/antagonists & inhibitors ; Receptor, trkC/genetics ; Receptor, trkC/metabolism ; SOX9 Transcription Factor/genetics ; SOX9 Transcription Factor/metabolism ; Signal Transduction ; Thy-1 Antigens/genetics ; Thy-1 Antigens/metabolism
Czasopismo naukowe
Tytuł :
Pharmacokinetic studies for cochlear drug delivery.
Autorzy :
Park K; Purdue University, Biomedical Engineering and Pharmaceutics, West Lafayette, IN 47907, USA. Electronic address: .
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Źródło :
Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2019 Apr 10; Vol. 299, pp. 165.
Typ publikacji :
Editorial
MeSH Terms :
Cochlea/*metabolism
Neurotrophin 3/*pharmacokinetics
Animals ; Drug Delivery Systems ; Hearing Loss/therapy ; Humans ; Injections ; Neurotrophin 3/administration & dosage
Opinia redakcyjna
Tytuł :
Effect of NT-3 on infection-induced memory impairment of neonatal rats.
Autorzy :
Liu DB; Department of Neurology, The Affiliated Jiangyin Hospital of Southeast University of Medical College, Jiangyin, Jiangsu, China. .
Yang JS
Lu QB
Zhu ZF
Fang Q
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Źródło :
European review for medical and pharmacological sciences [Eur Rev Med Pharmacol Sci] 2019 Mar; Vol. 23 (5), pp. 2182-2187.
Typ publikacji :
Journal Article
MeSH Terms :
Up-Regulation*
Amyloid beta-Protein Precursor/*adverse effects
Memory Disorders/*genetics
Meningitis, Bacterial/*psychology
Neurotrophin 3/*genetics
Peptide Fragments/*adverse effects
Animals ; Animals, Newborn ; Avoidance Learning ; Disease Models, Animal ; Female ; Male ; Maze Learning ; Memory Disorders/chemically induced ; Neurotrophin 3/metabolism ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Growth Factors in the Carotid Body-An Update.
Autorzy :
Stocco E; Department of Neurosciences, Institute of Human Anatomy, University of Padova, 35121 Padova, Italy.
Barbon S; Department of Neurosciences, Institute of Human Anatomy, University of Padova, 35121 Padova, Italy.
Tortorella C; Department of Neurosciences, Institute of Human Anatomy, University of Padova, 35121 Padova, Italy.
Macchi V; Department of Neurosciences, Institute of Human Anatomy, University of Padova, 35121 Padova, Italy.
De Caro R; Department of Neurosciences, Institute of Human Anatomy, University of Padova, 35121 Padova, Italy.
Porzionato A; Department of Neurosciences, Institute of Human Anatomy, University of Padova, 35121 Padova, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Oct 01; Vol. 21 (19). Date of Electronic Publication: 2020 Oct 01.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Brain-Derived Neurotrophic Factor/*genetics
Carotid Body/*metabolism
Hyperoxia/*genetics
Hypoxia/*genetics
Nerve Growth Factor/*genetics
Receptors, Growth Factor/*genetics
Animals ; Brain-Derived Neurotrophic Factor/metabolism ; Carotid Body/cytology ; Ciliary Neurotrophic Factor/genetics ; Ciliary Neurotrophic Factor/metabolism ; Epidermal Growth Factor/genetics ; Epidermal Growth Factor/metabolism ; Fibroblast Growth Factor 2/genetics ; Fibroblast Growth Factor 2/metabolism ; Gene Expression Regulation ; Glial Cell Line-Derived Neurotrophic Factor/genetics ; Glial Cell Line-Derived Neurotrophic Factor/metabolism ; Humans ; Hyperoxia/metabolism ; Hyperoxia/pathology ; Hypoxia/metabolism ; Hypoxia/pathology ; Insulin-Like Growth Factor I/genetics ; Insulin-Like Growth Factor I/metabolism ; Nerve Growth Factor/metabolism ; Neurotrophin 3/genetics ; Neurotrophin 3/metabolism ; Receptors, Growth Factor/metabolism ; Transforming Growth Factor alpha/genetics ; Transforming Growth Factor alpha/metabolism ; Transforming Growth Factor beta/genetics ; Transforming Growth Factor beta/metabolism ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/metabolism
Czasopismo naukowe
Tytuł :
Silver nanoparticles conjugated with Neurotrophin 3 upregulate myelin gene transcription pathway.
Autorzy :
Munir A; Department of Bioinformatics and Biosciences, Faculty of Health and Life Sciences, Capital University of Science and Technology (CUST), Islamabad Pakistan.
Hussain S; Department of Bioinformatics and Biosciences, Faculty of Health and Life Sciences, Capital University of Science and Technology (CUST), Islamabad Pakistan.
Dilshad E; Department of Bioinformatics and Biosciences, Faculty of Health and Life Sciences, Capital University of Science and Technology (CUST), Islamabad Pakistan. Electronic address: .
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Źródło :
Journal of theoretical biology [J Theor Biol] 2018 Dec 14; Vol. 459, pp. 111-118. Date of Electronic Publication: 2018 Sep 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Metal Nanoparticles/*chemistry
Myelin Sheath/*genetics
Neurotrophin 3/*chemistry
Silver/*chemistry
Transcription, Genetic/*drug effects
ErbB Receptors/metabolism ; Gene Expression ; Humans ; Models, Theoretical ; Mutation ; Neurotrophin 3/pharmacology ; Time Factors ; Up-Regulation/drug effects
Czasopismo naukowe

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