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Tytuł :
Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients.
Autorzy :
Aschenbrenner AC; Systems Medicine, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; PRECISE Platform for Single Cell Genomics and Epigenomics at the German Center for Neurodegenerative Diseases and the University of Bonn, Bonn, Germany.; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.
Mouktaroudi M; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
Krämer B; Department I of Internal Medicine, University Hospital of Bonn (UKB), Bonn, Germany.
Oestreich M; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
Antonakos N; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
Nuesch-Germano M; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
Gkizeli K; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
Bonaguro L; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
Reusch N; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
Baßler K; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
Saridaki M; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
Knoll R; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
Pecht T; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
Kapellos TS; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
Doulou S; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
Kröger C; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
Herbert M; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
Holsten L; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
Horne A; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
Gemünd ID; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
Rovina N; 1st Department of Pulmonary Medicine and Intensive Care Unit, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
Agrawal S; West German Genome Center (WGGC), University of Bonn, Bonn, Germany.
Dahm K; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
van Uelft M; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
Drews A; PRECISE Platform for Single Cell Genomics and Epigenomics at the German Center for Neurodegenerative Diseases and the University of Bonn, Bonn, Germany.
Lenkeit L; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
Bruse N; Department of Intensive Care Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.
Gerretsen J; Department of Intensive Care Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.
Gierlich J; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
Becker M; PRECISE Platform for Single Cell Genomics and Epigenomics at the German Center for Neurodegenerative Diseases and the University of Bonn, Bonn, Germany.
Händler K; PRECISE Platform for Single Cell Genomics and Epigenomics at the German Center for Neurodegenerative Diseases and the University of Bonn, Bonn, Germany.
Kraut M; PRECISE Platform for Single Cell Genomics and Epigenomics at the German Center for Neurodegenerative Diseases and the University of Bonn, Bonn, Germany.
Theis H; PRECISE Platform for Single Cell Genomics and Epigenomics at the German Center for Neurodegenerative Diseases and the University of Bonn, Bonn, Germany.
Mengiste S; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
De Domenico E; PRECISE Platform for Single Cell Genomics and Epigenomics at the German Center for Neurodegenerative Diseases and the University of Bonn, Bonn, Germany.
Schulte-Schrepping J; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
Seep L; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
Raabe J; Department I of Internal Medicine, University Hospital of Bonn (UKB), Bonn, Germany.
Hoffmeister C; Department I of Internal Medicine, University Hospital of Bonn (UKB), Bonn, Germany.
ToVinh M; Department I of Internal Medicine, University Hospital of Bonn (UKB), Bonn, Germany.
Keitel V; Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Rieke G; Department I of Internal Medicine, University Hospital of Bonn (UKB), Bonn, Germany.
Talevi V; Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Skowasch D; Department of Internal Medicine II, Section of Pneumology, University Hospital of Bonn (UKB), Bonn, Germany.
Aziz NA; Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Neurology, Faculty of Medicine, University of Bonn, Bonn, Germany.
Pickkers P; Department of Intensive Care Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.
van de Veerdonk FL; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.
Netea MG; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.; Immunology & Metabolism, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
Schultze JL; Systems Medicine, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; PRECISE Platform for Single Cell Genomics and Epigenomics at the German Center for Neurodegenerative Diseases and the University of Bonn, Bonn, Germany.; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
Kox M; Department of Intensive Care Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.
Breteler MMB; Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Institute for Medical Biometry, Informatics and Epidemiology (IMBIE), Faculty of Medicine, University of Bonn, Bonn, Germany.
Nattermann J; Department I of Internal Medicine, University Hospital of Bonn (UKB), Bonn, Germany.; German Center for Infection Research (DZIF), Bonn, Germany.
Koutsoukou A; 1st Department of Pulmonary Medicine and Intensive Care Unit, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
Giamarellos-Bourboulis EJ; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
Ulas T; Systems Medicine, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany. .; PRECISE Platform for Single Cell Genomics and Epigenomics at the German Center for Neurodegenerative Diseases and the University of Bonn, Bonn, Germany. .
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Corporate Authors :
German COVID-19 Omics Initiative (DeCOI)
Źródło :
Genome medicine [Genome Med] 2021 Jan 13; Vol. 13 (1), pp. 7. Date of Electronic Publication: 2021 Jan 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcriptome*
COVID-19/*pathology
Neutrophils/*metabolism
Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; COVID-19/virology ; Case-Control Studies ; Down-Regulation ; Drug Repositioning ; Humans ; Neutrophils/cytology ; Neutrophils/immunology ; Phenotype ; Principal Component Analysis ; RNA/blood ; RNA/chemistry ; RNA/metabolism ; Sequence Analysis, RNA ; Severity of Illness Index ; Up-Regulation
Czasopismo naukowe
Tytuł :
Neutrophil calprotectin identifies severe pulmonary disease in COVID-19.
Autorzy :
Shi H; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Division of Rheumatology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zuo Y; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Yalavarthi S; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Gockman K; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Zuo M; Division of Geriatric and Palliative Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Madison JA; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Blair C; Division of Infectious Disease, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Woodward W; Michigan Clinical Research Unit, University of Michigan, Ann Arbor, Michigan, USA.
Lezak SP; Michigan Clinical Research Unit, University of Michigan, Ann Arbor, Michigan, USA.
Lugogo NL; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Woods RJ; Division of Infectious Disease, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Lood C; Division of Rheumatology, University of Washington, Department of Medicine, Seattle, Washington, USA.
Knight JS; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Kanthi Y; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Laboratory of Vascular Thrombosis and Inflammation, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2021 Jan; Vol. 109 (1), pp. 67-72. Date of Electronic Publication: 2020 Sep 01.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
COVID-19*/blood
COVID-19*/immunology
COVID-19*/pathology
COVID-19*/therapy
Calgranulin A*/blood
Calgranulin A*/immunology
Calgranulin B*/blood
Calgranulin B*/immunology
Neutrophil Activation*
Neutrophils*/immunology
Neutrophils*/metabolism
Neutrophils*/pathology
SARS-CoV-2*/immunology
SARS-CoV-2*/metabolism
Female ; Hospitalization ; Humans ; Male ; Middle Aged ; Severity of Illness Index ; Time Factors
Czasopismo naukowe
Tytuł :
Neutrophils mediate Th17 promotion in COVID-19 patients.
Autorzy :
Parackova Z; Department of Immunology, 2nd Faculty of Medicine Charles University, V Uvalu, University Hospital in Motol, Prague, Czech Republic.
Bloomfield M; Department of Immunology, 2nd Faculty of Medicine Charles University, V Uvalu, University Hospital in Motol, Prague, Czech Republic.; Department of Pediatrics, Thomayer's Hospital and First Faculty of Medicine, Charles University, Prague, Czech Republic.
Klocperk A; Department of Immunology, 2nd Faculty of Medicine Charles University, V Uvalu, University Hospital in Motol, Prague, Czech Republic.
Sediva A; Department of Immunology, 2nd Faculty of Medicine Charles University, V Uvalu, University Hospital in Motol, Prague, Czech Republic.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2021 Jan; Vol. 109 (1), pp. 73-76. Date of Electronic Publication: 2020 Dec 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Neutrophil Activation*
COVID-19/*immunology
Interleukin-17/*immunology
Neutrophils/*immunology
SARS-CoV-2/*immunology
Th17 Cells/*immunology
COVID-19/pathology ; Humans ; Neutrophils/pathology ; Th1 Cells/immunology ; Th1 Cells/pathology ; Th17 Cells/pathology
Czasopismo naukowe
Tytuł :
Sheng-Mai Yin exerts anti-inflammatory effects on RAW 264.7 cells and zebrafish.
Autorzy :
Zheng Y; Traditional Chinese Pharmacological Laboratory, Third Level Research Laboratory of State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, PR China; Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, Guangzhou, 510515, PR China.
Tian C; Traditional Chinese Pharmacological Laboratory, Third Level Research Laboratory of State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, PR China; Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, Guangzhou, 510515, PR China.
Fan C; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, PR China.
Xu N; Traditional Chinese Pharmacological Laboratory, Third Level Research Laboratory of State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, PR China; Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, Guangzhou, 510515, PR China.
Xiao J; Traditional Chinese Pharmacological Laboratory, Third Level Research Laboratory of State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, PR China; Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, Guangzhou, 510515, PR China.
Zhao X; Traditional Chinese Pharmacological Laboratory, Third Level Research Laboratory of State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, PR China; Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, Guangzhou, 510515, PR China.
Lu Z; Traditional Chinese Pharmacological Laboratory, Third Level Research Laboratory of State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, PR China; Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, Guangzhou, 510515, PR China.
Cao H; Traditional Chinese Pharmacological Laboratory, Third Level Research Laboratory of State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, PR China; Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, Guangzhou, 510515, PR China.
Liu J; Traditional Chinese Pharmacological Laboratory, Third Level Research Laboratory of State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, PR China; Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, Guangzhou, 510515, PR China. Electronic address: .
Yu L; Traditional Chinese Pharmacological Laboratory, Third Level Research Laboratory of State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, PR China; Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, Guangzhou, 510515, PR China. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 Mar 01; Vol. 267, pp. 113497. Date of Electronic Publication: 2020 Oct 19.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
Drugs, Chinese Herbal/*pharmacology
Inflammation/*prevention & control
Inflammation Mediators/*metabolism
Macrophages/*drug effects
Neutrophils/*drug effects
Animals ; Animals, Genetically Modified ; Copper Sulfate ; Cytokines/metabolism ; Disease Models, Animal ; Drug Combinations ; Inflammation/chemically induced ; Inflammation/immunology ; Inflammation/metabolism ; Lipopolysaccharides ; Macrophages/immunology ; Macrophages/metabolism ; Mice ; NF-KappaB Inhibitor alpha/metabolism ; NF-kappa B/metabolism ; Neutrophil Infiltration/drug effects ; Neutrophils/immunology ; Neutrophils/metabolism ; RAW 264.7 Cells ; STAT3 Transcription Factor/metabolism ; Signal Transduction ; Zebrafish/embryology ; Zebrafish/genetics ; Zebrafish Proteins/metabolism
Czasopismo naukowe
Tytuł :
Monitoring neutrophil-to-lymphocyte ratio in patients with coronavirus disease 2019 receiving tocilizumab.
Autorzy :
Hartog NL; Michigan State University College of Human Medicine; Pediatric Allergy and Immunology, Helen DeVos Children's Hospital; Allergy and Immunology, Spectrum Health. Electronic address: .
Davis AT; Department of Surgery, Michigan State University College of Human Medicine; Office of Research and Education, Spectrum Health.
Prokop JW; Department of Pediatrics and Human Development, Michigan State University College of Human Medicine; Department of Pharmacology and Toxicology, Michigan State University.
Walls A; Pediatric Intensive Care Unit, Helen DeVos Children's Hospital, Spectrum Health, Grand Rapids, Michigan.
Rajasekaran S; Michigan State University College of Human Medicine; Allergy and Immunology, Spectrum Health; Department of Pediatrics and Human Development, Michigan State University College of Human Medicine; Pediatric Intensive Care Unit, Helen DeVos Children's Hospital, Spectrum Health, Grand Rapids, Michigan.
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Źródło :
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology [Ann Allergy Asthma Immunol] 2021 Mar; Vol. 126 (3), pp. 306-308. Date of Electronic Publication: 2020 Dec 30.
Typ publikacji :
Letter
MeSH Terms :
Antibodies, Monoclonal, Humanized/*drug effects
COVID-19/*drug therapy
Diabetes Mellitus/*drug therapy
Hypertension/*drug therapy
Lymphocytes/*pathology
Neutrophils/*pathology
Adult ; Aged ; Biomarkers/analysis ; COVID-19/diagnosis ; COVID-19/immunology ; COVID-19/mortality ; Comorbidity ; Diabetes Mellitus/diagnosis ; Diabetes Mellitus/immunology ; Diabetes Mellitus/mortality ; Female ; Humans ; Hypertension/diagnosis ; Hypertension/immunology ; Hypertension/mortality ; Leukocyte Count ; Lymphocytes/immunology ; Lymphocytes/virology ; Male ; Middle Aged ; Neutrophils/immunology ; Neutrophils/virology ; Prognosis ; Risk Factors ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; Severity of Illness Index ; Survival Analysis
SCR Protocol :
COVID-19 drug treatment
Opinia redakcyjna
Tytuł :
Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19.
Autorzy :
Guo Q; Institute of Systems Biomedicine, Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center, Beijing, China.
Zhao Y; Institute of Systems Biomedicine, Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center, Beijing, China.
Li J; University of Chinese Academy of Sciences, CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Liu J; Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing, China.
Yang X; Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing, China.
Guo X; Institute of Systems Biomedicine, Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center, Beijing, China.
Kuang M; Institute of Systems Biomedicine, Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center, Beijing, China.
Xia H; Institute of Systems Biomedicine, Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center, Beijing, China.
Zhang Z; Institute of Systems Biomedicine, Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center, Beijing, China.
Cao L; Institute of Systems Biomedicine, Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center, Beijing, China.
Luo Y; Institute of Systems Biomedicine, Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center, Beijing, China.
Bao L; Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing, China.
Wang X; Institute of Systems Biomedicine, Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center, Beijing, China.
Wei X; Institute of Systems Biomedicine, Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center, Beijing, China.
Deng W; Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing, China.
Wang N; University of Chinese Academy of Sciences, CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Chen L; Institute of Systems Biomedicine, Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center, Beijing, China.
Chen J; Institute of Systems Biomedicine, Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center, Beijing, China.
Zhu H; Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing, China.
Gao R; Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing, China.
Qin C; Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing, China. Electronic address: .
Wang X; University of Chinese Academy of Sciences, CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. Electronic address: .
You F; Institute of Systems Biomedicine, Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center, Beijing, China. Electronic address: .
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Źródło :
Cell host & microbe [Cell Host Microbe] 2021 Feb 10; Vol. 29 (2), pp. 222-235.e4. Date of Electronic Publication: 2020 Dec 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alarmins/*pharmacology
Antiviral Agents/*pharmacology
COVID-19/*drug therapy
Neutrophils/*drug effects
SARS-CoV-2/*drug effects
Animals ; COVID-19/metabolism ; COVID-19/virology ; Disease Models, Animal ; Female ; Humans ; Macaca mulatta ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neutrophils/metabolism ; Transcriptome ; Viral Load
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Vascular neutrophilic inflammation and immunothrombosis distinguish severe COVID-19 from influenza pneumonia.
Autorzy :
Nicolai L; Medizinische Klinik und Poliklinik I, University Hospital, LMU Munich, Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.; COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, LMU, Munich, Germany.
Leunig A; Medizinische Klinik und Poliklinik I, University Hospital, LMU Munich, Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
Brambs S; Medizinische Klinik und Poliklinik I, University Hospital, LMU Munich, Munich, Germany.
Kaiser R; Medizinische Klinik und Poliklinik I, University Hospital, LMU Munich, Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.; COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, LMU, Munich, Germany.
Joppich M; Department of Informatics, Ludwig-Maximilians-Universität München, Munich, Germany.
Hoffknecht ML; Medizinische Klinik und Poliklinik I, University Hospital, LMU Munich, Munich, Germany.
Gold C; Medizinische Klinik und Poliklinik I, University Hospital, LMU Munich, Munich, Germany.
Engel A; Medizinische Klinik und Poliklinik I, University Hospital, LMU Munich, Munich, Germany.
Polewka V; Medizinische Klinik und Poliklinik I, University Hospital, LMU Munich, Munich, Germany.
Muenchhoff M; COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, LMU, Munich, Germany.; Virology, Max von Pettenkofer Institute, Ludwig-Maximilians-Universität München, Munich, Germany.; German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany.
Hellmuth JC; COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, LMU, Munich, Germany.; Medizinische Klinik und Poliklinik III, University Hospital LMU Munich, Munich, Germany.; German Cancer Consortium (DKTK), Munich, Germany.
Ruhle A; COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, LMU, Munich, Germany.; Virology, Max von Pettenkofer Institute, Ludwig-Maximilians-Universität München, Munich, Germany.
Ledderose S; Institute of Pathology, Ludwig-Maximilians-Universität München, Munich, Germany.
Weinberger T; Medizinische Klinik und Poliklinik I, University Hospital, LMU Munich, Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.; COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, LMU, Munich, Germany.
Schulz H; Institute of Pathology, Ludwig-Maximilians-Universität München, Munich, Germany.
Scherer C; Medizinische Klinik und Poliklinik I, University Hospital, LMU Munich, Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.; COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, LMU, Munich, Germany.
Rudelius M; Institute of Pathology, Ludwig-Maximilians-Universität München, Munich, Germany.
Zoller M; Department of Anesthesiology, University Hospital, LMU, Munich, Germany.
Keppler OT; COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, LMU, Munich, Germany.; Virology, Max von Pettenkofer Institute, Ludwig-Maximilians-Universität München, Munich, Germany.; German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany.
Zwißler B; Department of Anesthesiology, University Hospital, LMU, Munich, Germany.
von Bergwelt-Baildon M; COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, LMU, Munich, Germany.; Medizinische Klinik und Poliklinik III, University Hospital LMU Munich, Munich, Germany.; German Cancer Consortium (DKTK), Munich, Germany.
Kääb S; Medizinische Klinik und Poliklinik I, University Hospital, LMU Munich, Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.; COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, LMU, Munich, Germany.
Zimmer R; Department of Informatics, Ludwig-Maximilians-Universität München, Munich, Germany.
Bülow RD; Institute of Pathology, University Clinic of RWTH, Aachen, Germany.
von Stillfried S; Institute of Pathology, University Clinic of RWTH, Aachen, Germany.
Boor P; Institute of Pathology, University Clinic of RWTH, Aachen, Germany.; DeRegCOVID Registry.
Massberg S; Medizinische Klinik und Poliklinik I, University Hospital, LMU Munich, Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.; COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, LMU, Munich, Germany.
Pekayvaz K; Medizinische Klinik und Poliklinik I, University Hospital, LMU Munich, Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.; COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, LMU, Munich, Germany.
Stark K; Medizinische Klinik und Poliklinik I, University Hospital, LMU Munich, Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.; COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, LMU, Munich, Germany.
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Źródło :
Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2021 Feb; Vol. 19 (2), pp. 574-581. Date of Electronic Publication: 2020 Dec 20.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunity, Innate*
COVID-19/*immunology
Influenza, Human/*immunology
Lung/*immunology
Neutrophils/*immunology
Thrombosis/*immunology
Vasculitis/*immunology
COVID-19/diagnosis ; COVID-19/virology ; Diagnosis, Differential ; Host-Pathogen Interactions ; Humans ; Influenza, Human/diagnosis ; Influenza, Human/virology ; Lung/pathology ; Lung/virology ; Neutrophils/virology ; Predictive Value of Tests ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; Thrombosis/virology ; Vasculitis/virology
Czasopismo naukowe
Tytuł :
Can immunological manipulation defeat SARS-CoV-2? Why G-CSF induced neutrophil expansion is worth a clinical trial: G-CSF treatment against COVID-19.
Autorzy :
Katayama H; Katayama Dermatology Clinic, Maebashi, Gunma, Japan.
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Źródło :
BioEssays : news and reviews in molecular, cellular and developmental biology [Bioessays] 2021 Feb; Vol. 43 (2), pp. e2000232. Date of Electronic Publication: 2020 Nov 09.
Typ publikacji :
Journal Article
MeSH Terms :
Granulocyte Colony-Stimulating Factor/*therapeutic use
Neutrophils/*immunology
SARS-CoV-2/*immunology
Th1 Cells/*immunology
Th17 Cells/*immunology
COVID-19/drug therapy ; COVID-19/immunology ; Chemokine CCL20/metabolism ; Humans ; Immunologic Memory/immunology ; Interleukin-17/metabolism ; Interleukin-23 Subunit p19/immunology ; Neutrophils/drug effects ; Th17 Cells/drug effects
Czasopismo naukowe
Tytuł :
Asthma in elderly is characterized by increased sputum neutrophils, lower airway caliber variability and air trapping.
Autorzy :
Schleich F; Respiratory Medicine CHU Sart-Tilman, University of Liege, Sart-Tilman Liege, B35, GIGA I3, Liege, Belgium. .
Graff S; Respiratory Medicine CHU Sart-Tilman, University of Liege, Sart-Tilman Liege, B35, GIGA I3, Liege, Belgium.
Guissard F; Respiratory Medicine CHU Sart-Tilman, University of Liege, Sart-Tilman Liege, B35, GIGA I3, Liege, Belgium.
Henket M; Respiratory Medicine CHU Sart-Tilman, University of Liege, Sart-Tilman Liege, B35, GIGA I3, Liege, Belgium.
Paulus V; Respiratory Medicine CHU Sart-Tilman, University of Liege, Sart-Tilman Liege, B35, GIGA I3, Liege, Belgium.
Louis R; Respiratory Medicine CHU Sart-Tilman, University of Liege, Sart-Tilman Liege, B35, GIGA I3, Liege, Belgium.
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Źródło :
Respiratory research [Respir Res] 2021 Jan 13; Vol. 22 (1), pp. 15. Date of Electronic Publication: 2021 Jan 13.
Typ publikacji :
Journal Article
MeSH Terms :
Asthma/*metabolism
Forced Expiratory Volume/*physiology
Inflammation Mediators/*metabolism
Neutrophils/*metabolism
Respiratory Function Tests/*methods
Sputum/*metabolism
Adult ; Aged ; Aged, 80 and over ; Asthma/diagnosis ; Asthma/immunology ; Female ; Humans ; Inflammation Mediators/immunology ; Male ; Middle Aged ; Neutrophils/immunology ; Retrospective Studies ; Sputum/immunology
Czasopismo naukowe
Tytuł :
Lophatherum gracile Brongn. attenuates neutrophilic inflammation through inhibition of JNK and calcium.
Autorzy :
Lai KH; Research Center for Chinese Herbal Medicine, Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, 33303, Taiwan; Graduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei, 11031, Taiwan. Electronic address: .
Chen PJ; Department of Cosmetic Science, Providence University, Taichung, 43301, Taiwan. Electronic address: .
Chen CC; Graduate Institute of Natural Products, School of Traditional Chinese Medicine, Chang Gung University, Taoyuan, 33302, Taiwan. Electronic address: .
Yang SH; Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan, 33305, Taiwan; School of Traditional Chinese Medicine, Chang Gung University, Taoyuan, 33302, Taiwan. Electronic address: .
El-Shazly M; Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, Ain-Shams University, Organization of African Unity Street, Abassia, Cairo, 11566, Egypt; Department of Pharmaceutical Biology, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, 11432, Egypt. Electronic address: .
Chang YC; Research Center for Chinese Herbal Medicine, Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, 33303, Taiwan. Electronic address: .
Wu YH; Research Center for Chinese Herbal Medicine, Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, 33303, Taiwan. Electronic address: .
Wu YH; Graduate Institute of Natural Products, School of Traditional Chinese Medicine, Chang Gung University, Taoyuan, 33302, Taiwan. Electronic address: .
Wang YH; Graduate Institute of Natural Products, School of Traditional Chinese Medicine, Chang Gung University, Taoyuan, 33302, Taiwan. Electronic address: .
Hsieh HL; Research Center for Chinese Herbal Medicine, Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, 33303, Taiwan; Department of Nursing, Division of Basic Medical Sciences, Chang Gung University of Science and Technology, Taoyuan, 33303, Taiwan; Department of Neurology, Chang Gung Memorial Hospital, Taoyuan, 33305, Taiwan. Electronic address: .
Hwang TL; Research Center for Chinese Herbal Medicine, Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, 33303, Taiwan; Graduate Institute of Natural Products, School of Traditional Chinese Medicine, Chang Gung University, Taoyuan, 33302, Taiwan; Research Center for Food and Cosmetic Safety, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, 33303, Taiwan; Department of Anaesthesiology, Chang Gung Memorial Hospital, Taoyuan, 33305, Taiwan; Department of Chemical Engineering, Ming Chi University of Technology, New Taipei City, 24301, Taiwan. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 Jan 10; Vol. 264, pp. 113224. Date of Electronic Publication: 2020 Aug 12.
Typ publikacji :
Journal Article
MeSH Terms :
Plants, Medicinal*
Anti-Inflammatory Agents/*pharmacology
Calcium Signaling/*drug effects
Drugs, Chinese Herbal/*pharmacology
MAP Kinase Signaling System/*drug effects
Neutrophils/*drug effects
Adult ; Anti-Inflammatory Agents/isolation & purification ; Calcium Signaling/physiology ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal/isolation & purification ; Female ; Humans ; MAP Kinase Signaling System/physiology ; Male ; Neutrophils/metabolism ; Neutrophils/pathology ; Young Adult
Czasopismo naukowe
Tytuł :
Hyaluronidase Impairs Neutrophil Function and Promotes Group B Streptococcus Invasion and Preterm Labor in Nonhuman Primates.
Autorzy :
Coleman M; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
Armistead B; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.; Department of Global Health, University of Washington, Seattle, Washington, USA.
Orvis A; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
Quach P; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
Brokaw A; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.; Department of Global Health, University of Washington, Seattle, Washington, USA.
Gendrin C; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
Sharma K; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
Ogle J; Washington National Primate Research Center, Seattle, Washington, USA.
Merillat S; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
Dacanay M; Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, Washington, USA.
Wu TY; Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, Washington, USA.
Munson J; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA.
Baldessari A; Washington National Primate Research Center, Seattle, Washington, USA.
Vornhagen J; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.; Department of Global Health, University of Washington, Seattle, Washington, USA.
Furuta A; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.; Department of Global Health, University of Washington, Seattle, Washington, USA.
Nguyen S; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
Adams Waldorf KM; Department of Global Health, University of Washington, Seattle, Washington, USA .; Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, Washington, USA.; Center for Innate Immunity and Immune Disease, University of Washington, Seattle, Washington, USA.; Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Rajagopal L; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA .; Department of Global Health, University of Washington, Seattle, Washington, USA.; Center for Innate Immunity and Immune Disease, University of Washington, Seattle, Washington, USA.; Department of Pediatrics, University of Washington, Seattle, Washington, USA.
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Źródło :
MBio [mBio] 2021 Jan 05; Vol. 12 (1). Date of Electronic Publication: 2021 Jan 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Hyaluronoglucosaminidase/*metabolism
Neutrophils/*immunology
Obstetric Labor, Premature/*immunology
Streptococcal Infections/*immunology
Streptococcus agalactiae/*metabolism
Amniotic Fluid/microbiology ; Animals ; Cytokines/metabolism ; Disease Models, Animal ; Female ; Humans ; Hyaluronoglucosaminidase/genetics ; Inflammation ; Lung/microbiology ; Lung/pathology ; Macaca nemestrina ; Neutrophils/microbiology ; Pregnancy ; Premature Birth ; Primates ; Streptococcal Infections/metabolism ; Streptococcal Infections/microbiology ; Streptococcus agalactiae/enzymology ; Streptococcus agalactiae/genetics ; Streptococcus agalactiae/immunology
Czasopismo naukowe
Tytuł :
Flow cytometric evaluation of the neutrophil compartment in COVID-19 at hospital presentation: A normal response to an abnormal situation.
Autorzy :
Spijkerman R; Department of Respiratory Medicine, University Medical Center Utrecht, Heidelberglaan, Utrecht, The Netherlands.; Department of Trauma Surgery, University Medical Center Utrecht, Heidelberglaan, Utrecht, The Netherlands.; Center for Translational Immunology (CTI), University Medical Center Utrecht, Heidelberglaan, Utrecht, The Netherlands.
Bongers SH; Department of Trauma Surgery, University Medical Center Utrecht, Heidelberglaan, Utrecht, The Netherlands.; Center for Translational Immunology (CTI), University Medical Center Utrecht, Heidelberglaan, Utrecht, The Netherlands.
Bindels BJJ; Department of Respiratory Medicine, University Medical Center Utrecht, Heidelberglaan, Utrecht, The Netherlands.; Center for Translational Immunology (CTI), University Medical Center Utrecht, Heidelberglaan, Utrecht, The Netherlands.
Tinnevelt GH; Institute for Molecules and Materials, Radboud University, Heyendaalseweg, Nijmegen, The Netherlands.
Giustarini G; Department of Respiratory Medicine, University Medical Center Utrecht, Heidelberglaan, Utrecht, The Netherlands.; Center for Translational Immunology (CTI), University Medical Center Utrecht, Heidelberglaan, Utrecht, The Netherlands.
Jorritsma NKN; Department of Respiratory Medicine, University Medical Center Utrecht, Heidelberglaan, Utrecht, The Netherlands.; Center for Translational Immunology (CTI), University Medical Center Utrecht, Heidelberglaan, Utrecht, The Netherlands.
Buitenwerf W; Department of Respiratory Medicine, University Medical Center Utrecht, Heidelberglaan, Utrecht, The Netherlands.; Center for Translational Immunology (CTI), University Medical Center Utrecht, Heidelberglaan, Utrecht, The Netherlands.
van Spengler DEJ; Department of Respiratory Medicine, University Medical Center Utrecht, Heidelberglaan, Utrecht, The Netherlands.; Center for Translational Immunology (CTI), University Medical Center Utrecht, Heidelberglaan, Utrecht, The Netherlands.
Delemarre EM; Center for Translational Immunology (CTI), University Medical Center Utrecht, Heidelberglaan, Utrecht, The Netherlands.
Nierkens S; Center for Translational Immunology (CTI), University Medical Center Utrecht, Heidelberglaan, Utrecht, The Netherlands.
van Goor HMR; Department of Internal Medicine, University Medical Center Utrecht, Heidelberglaan, Utrecht, The Netherlands.
Jansen JJ; Institute for Molecules and Materials, Radboud University, Heyendaalseweg, Nijmegen, The Netherlands.
Vrisekoop N; Department of Respiratory Medicine, University Medical Center Utrecht, Heidelberglaan, Utrecht, The Netherlands.; Center for Translational Immunology (CTI), University Medical Center Utrecht, Heidelberglaan, Utrecht, The Netherlands.
Hietbrink F; Department of Trauma Surgery, University Medical Center Utrecht, Heidelberglaan, Utrecht, The Netherlands.
Leenen LPH; Department of Trauma Surgery, University Medical Center Utrecht, Heidelberglaan, Utrecht, The Netherlands.
Kaasjager KAH; Department of Internal Medicine, University Medical Center Utrecht, Heidelberglaan, Utrecht, The Netherlands.
Koenderman L; Department of Respiratory Medicine, University Medical Center Utrecht, Heidelberglaan, Utrecht, The Netherlands.; Center for Translational Immunology (CTI), University Medical Center Utrecht, Heidelberglaan, Utrecht, The Netherlands.
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Corporate Authors :
COVPACH study group; Department of Respiratory Medicine, University Medical Center Utrecht, Heidelberglaan, Utrecht, The Netherlands.
Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2021 Jan; Vol. 109 (1), pp. 99-114.
Typ publikacji :
Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19*/blood
COVID-19*/immunology
COVID-19*/pathology
Flow Cytometry*
Neutrophil Activation*
Neutrophils*/immunology
Neutrophils*/metabolism
Neutrophils*/pathology
SARS-CoV-2*/immunology
SARS-CoV-2*/metabolism
Aged ; Antigens, CD/blood ; Antigens, CD/immunology ; Female ; Hospitals ; Humans ; Inflammation/blood ; Inflammation/immunology ; Inflammation/pathology ; Male ; Middle Aged
Czasopismo naukowe
Tytuł :
Eimeria ninakohlyakimovae casts NOX-independent NETosis and induces enhanced IL-12, TNF-α, IL-6, CCL2 and iNOS gene transcription in caprine PMN.
Autorzy :
Pérez D; Parasitology Unit, Department of Animal Pathology, Faculty of Veterinary Medicine, University of Las Palmas de Gran Canaria, Las Palmas, Spain.
Muñoz-Caro T; Escuela de Medicina Veterinaria, Facultad de Recursos Naturales y Medicina Veterinaria, Universidad Santo Tomas, Chile.
Silva LMR; Institute of Parasitology, Faculty of Veterinary Medicine, Justus Liebig University Giessen, Giessen, Germany.
Muñoz MC; Parasitology Unit, Department of Animal Pathology, Faculty of Veterinary Medicine, University of Las Palmas de Gran Canaria, Las Palmas, Spain.
Molina JM; Parasitology Unit, Department of Animal Pathology, Faculty of Veterinary Medicine, University of Las Palmas de Gran Canaria, Las Palmas, Spain.
Taubert A; Institute of Parasitology, Faculty of Veterinary Medicine, Justus Liebig University Giessen, Giessen, Germany.
Hermosilla C; Institute of Parasitology, Faculty of Veterinary Medicine, Justus Liebig University Giessen, Giessen, Germany.
Ruiz A; Parasitology Unit, Department of Animal Pathology, Faculty of Veterinary Medicine, University of Las Palmas de Gran Canaria, Las Palmas, Spain. Electronic address: .
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Źródło :
Experimental parasitology [Exp Parasitol] 2021 Jan; Vol. 220, pp. 108034. Date of Electronic Publication: 2020 Nov 12.
Typ publikacji :
Journal Article
MeSH Terms :
Coccidiosis/*veterinary
Cytokines/*genetics
Eimeria/*immunology
Goat Diseases/*parasitology
Neutrophils/*parasitology
Analysis of Variance ; Animals ; Chemokine CCL2/genetics ; Chemokine CCL2/metabolism ; Coccidiosis/immunology ; Coccidiosis/parasitology ; Colitis/parasitology ; Colitis/veterinary ; Cytokines/metabolism ; Eimeria/genetics ; Eimeria/ultrastructure ; Gastrointestinal Hemorrhage/parasitology ; Gastrointestinal Hemorrhage/veterinary ; Goat Diseases/immunology ; Goats ; Interleukin-12/genetics ; Interleukin-12/metabolism ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Microscopy, Electron, Scanning/veterinary ; NADPH Oxidases/metabolism ; Neutrophils/immunology ; Neutrophils/ultrastructure ; Nitric Oxide Synthase Type II/genetics ; Nitric Oxide Synthase Type II/metabolism ; Oocysts/genetics ; Oocysts/immunology ; Polymerase Chain Reaction/veterinary ; Sporozoites/genetics ; Sporozoites/immunology ; Transcription, Genetic ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism ; Typhlitis/parasitology ; Typhlitis/veterinary ; Up-Regulation
Czasopismo naukowe
Tytuł :
Peripheral neutrophil phenotypes during management of periodontitis.
Autorzy :
Medara N; Melbourne Dental School, The University of Melbourne, Carlton, VIC, Australia.
Lenzo JC; Melbourne Dental School, The University of Melbourne, Carlton, VIC, Australia.; Centre for Oral Health Research, Melbourne Dental School, The University of Melbourne, Carlton, VIC, Australia.
Walsh KA; Austin Hospital, Heidelberg, VIC, Australia.
Reynolds EC; Melbourne Dental School, The University of Melbourne, Carlton, VIC, Australia.; Centre for Oral Health Research, Melbourne Dental School, The University of Melbourne, Carlton, VIC, Australia.
O'Brien-Simpson NM; Melbourne Dental School, The University of Melbourne, Carlton, VIC, Australia.; Centre for Oral Health Research, Melbourne Dental School, The University of Melbourne, Carlton, VIC, Australia.
Darby IB; Melbourne Dental School, The University of Melbourne, Carlton, VIC, Australia.
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Źródło :
Journal of periodontal research [J Periodontal Res] 2021 Jan; Vol. 56 (1), pp. 58-68. Date of Electronic Publication: 2020 Aug 17.
Typ publikacji :
Journal Article
MeSH Terms :
Neutrophils*
Periodontitis*/therapy
Flow Cytometry ; Humans ; Phenotype
Czasopismo naukowe
Tytuł :
Protective effect of ISO-1 with inhibition of RIPK3 up-regulation and neutrophilic accumulation on acetaminophen-induced liver injury in mice.
Autorzy :
Ohkawara T; Pathophysiology and Therapeutics, Hokkaido University Faculty of Pharmaceutical Sciences, kita-12, nishi-6, kita-ku Sapporo, 060-8638, Japan. Electronic address: .
Okubo N; Pathophysiology and Therapeutics, Hokkaido University Faculty of Pharmaceutical Sciences, kita-12, nishi-6, kita-ku Sapporo, 060-8638, Japan.
Maehara O; Pathophysiology and Therapeutics, Hokkaido University Faculty of Pharmaceutical Sciences, kita-12, nishi-6, kita-ku Sapporo, 060-8638, Japan.
Nishihira J; Department of Medical Management and Informatics, Faculty of Business Administration and Information Science, Hokkaido Information University, Nishinopporo, 59-2, Ebetsu, 069-8585, Japan.
Takeda H; Pathophysiology and Therapeutics, Hokkaido University Faculty of Pharmaceutical Sciences, kita-12, nishi-6, kita-ku Sapporo, 060-8638, Japan.
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Mar 15; Vol. 339, pp. 51-59. Date of Electronic Publication: 2020 Dec 25.
Typ publikacji :
Journal Article
MeSH Terms :
Acetaminophen/*toxicity
Acetates/*administration & dosage
Chemical and Drug Induced Liver Injury, Chronic/*prevention & control
Neutrophils/*drug effects
Oxazoles/*administration & dosage
Protective Agents/*administration & dosage
Receptor-Interacting Protein Serine-Threonine Kinases/*drug effects
Up-Regulation/*drug effects
Animals ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Models, Animal ; Neutrophils/metabolism ; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł :
Sodium molybdate induces heterophil extracellular traps formation in chicken.
Autorzy :
Jiang A; College of Life Sciences and Engineering, Foshan University, Foshan 528225, Guangdong, PR China; College of Veterinary Medicine, Jilin University, Changchun 130062, Jilin, PR China.
Zhang Y; College of Life Sciences and Engineering, Foshan University, Foshan 528225, Guangdong, PR China; College of Veterinary Medicine, Jilin University, Changchun 130062, Jilin, PR China.
Wu D; College of Life Sciences and Engineering, Foshan University, Foshan 528225, Guangdong, PR China; College of Veterinary Medicine, Jilin University, Changchun 130062, Jilin, PR China.
Li S; College of Life Sciences and Engineering, Foshan University, Foshan 528225, Guangdong, PR China; College of Veterinary Medicine, Jilin University, Changchun 130062, Jilin, PR China.
Liu Z; College of Life Sciences and Engineering, Foshan University, Foshan 528225, Guangdong, PR China; College of Veterinary Medicine, Jilin University, Changchun 130062, Jilin, PR China.
Yang Z; College of Life Sciences and Engineering, Foshan University, Foshan 528225, Guangdong, PR China.
Wei Z; College of Life Sciences and Engineering, Foshan University, Foshan 528225, Guangdong, PR China. Electronic address: .
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2021 Mar 01; Vol. 210, pp. 111886. Date of Electronic Publication: 2021 Jan 08.
Typ publikacji :
Journal Article
MeSH Terms :
Chickens/*immunology
Extracellular Traps/*drug effects
Molybdenum/*toxicity
Neutrophils/*drug effects
Animals ; Glucose Transporter Type 1/immunology ; Glucose Transporter Type 4/immunology ; Glycolysis ; Immunity, Innate/drug effects ; MAP Kinase Signaling System/drug effects ; NADPH Oxidases/immunology ; Neutrophils/immunology ; Reactive Oxygen Species/immunology
Czasopismo naukowe
Tytuł :
Differentiation of Tarchonanthus camphoratus L. and Tarchonanthus parvicapitulatus P.P.J. Herman (Asteraceae) using electron microscopy, and comparison of their biological activities.
Autorzy :
Aro AO; Department of Agriculture and Animal Health, Faculty of Agriculture and Environmental Sciences, University of South Africa, Florida Campus, South Africa. Electronic address: .
Famuyide IM; Phytomedicine Programme, Department of Paraclinical Sciences, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa. Electronic address: .
Elisha IL; Phytomedicine Group, Department of Pharmaceutical Sciences, Faculty of Science, Tshwane University of Technology, Private Bag X680 Arcadia, 0001, Pretoria, South Africa; Drug Development Section, Biochemistry Division, National Veterinary Research Institute, P.M.B. 01, Vom Plateau State, Nigeria. Electronic address: .
Kabongo-Kayoka PN; Department of Agriculture and Animal Health, Faculty of Agriculture and Environmental Sciences, University of South Africa, Florida Campus, South Africa. Electronic address: .
McGaw LJ; Phytomedicine Programme, Department of Paraclinical Sciences, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa. Electronic address: .
Kahler-Venter CP; Department of Pharmacology and Therapeutics, School of Medicine, Sefako Makgatho University of Health Sciences, Ga-rankuwa, South Africa. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 Mar 01; Vol. 267, pp. 113620. Date of Electronic Publication: 2020 Nov 25.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Asteraceae*/chemistry
Asteraceae*/classification
Asteraceae*/ultrastructure
Microscopy, Electron, Scanning*
Plant Leaves*/chemistry
Plant Leaves*/ultrastructure
Bronchodilator Agents/*pharmacology
Free Radical Scavengers/*pharmacology
Muscle Contraction/*drug effects
Neutrophils/*drug effects
Oxidative Stress/*drug effects
Plant Extracts/*pharmacology
Trachea/*drug effects
Adenosine Triphosphate/metabolism ; Animals ; Bronchodilator Agents/isolation & purification ; Free Radical Scavengers/isolation & purification ; Guinea Pigs ; Humans ; In Vitro Techniques ; Male ; Neutrophils/metabolism ; Plant Extracts/isolation & purification ; Superoxides/metabolism
Czasopismo naukowe
Tytuł :
Carboxypeptidase B blocks ex vivo activation of the anaphylatoxin-neutrophil extracellular trap axis in neutrophils from COVID-19 patients.
Autorzy :
Zhang Y; Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Han K; Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Du C; Department of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Li R; Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Liu J; Department of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Zeng H; Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China. .
Zhu L; Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China. .
Li A; Department of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China. .
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Źródło :
Critical care (London, England) [Crit Care] 2021 Feb 08; Vol. 25 (1), pp. 51. Date of Electronic Publication: 2021 Feb 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anaphylatoxins/*metabolism
COVID-19/*drug therapy
COVID-19/*immunology
Carboxypeptidase B/*metabolism
Carboxypeptidase B/*therapeutic use
Extracellular Traps/*drug effects
Neutrophils/*drug effects
Thrombosis/*prevention & control
Adult ; Aged ; COVID-19/physiopathology ; Extracellular Traps/immunology ; Female ; Humans ; Male ; Middle Aged ; Neutrophils/immunology ; Thrombosis/immunology
Czasopismo naukowe
Tytuł :
[Value of Neutrophil/Lymphocyte Ratio and Monocyte/Lymphocyte Ratio in the Prognosis of Patients with Multiple Myeloma].
Autorzy :
Yang WH; Gansu Provincial Hospital of TCM, Lanzhou 730000, Gansu Province, China,Ningxia Medical University, Yinchuan 750000, Ningxia Province, China.
Sun YQ; Department of Hematology, Gansu Provincial People's Hospital, Lanzhou 730000, Gansu Province, China,E-mail: .
Zhang QK; Department of Hematology, Gansu Provincial People's Hospital, Lanzhou 730000, Gansu Province, China.
Wei XF; Department of Hematology, Gansu Provincial People's Hospital, Lanzhou 730000, Gansu Province, China.
Li G; Department of Hematology, Gansu Provincial People's Hospital, Lanzhou 730000, Gansu Province, China.
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Źródło :
Zhongguo shi yan xue ye xue za zhi [Zhongguo Shi Yan Xue Ye Xue Za Zhi] 2021 Feb; Vol. 29 (1), pp. 122-130.
Typ publikacji :
Journal Article
MeSH Terms :
Multiple Myeloma*
Neutrophils*
Blood Platelets ; Humans ; Lymphocytes ; Monocytes ; Prognosis ; Retrospective Studies
Czasopismo naukowe

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