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Tytuł :
Efficacy of metformin and fermentable fiber combination therapy in adolescents with severe obesity and insulin resistance: study protocol for a double-blind randomized controlled trial.
Autorzy :
Deehan EC; Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, T6G 2E1, AB, Canada.
Colin-Ramirez E; Department of Pediatrics, University of Alberta, Edmonton, T6G 2E1, AB, Canada.
Triador L; Department of Pediatrics, University of Alberta, Edmonton, T6G 2E1, AB, Canada.
Madsen KL; Department of Medicine, University of Alberta, Edmonton, T6G 2C2, AB, Canada.
Prado CM; Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, T6G 2E1, AB, Canada.
Field CJ; Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, T6G 2E1, AB, Canada.
Ball GDC; Department of Pediatrics, University of Alberta, Edmonton, T6G 2E1, AB, Canada.
Tan Q; Department of Pediatrics, University of Alberta, Edmonton, T6G 2E1, AB, Canada.
Orsso C; Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, T6G 2E1, AB, Canada.
Dinu I; School of Public Health, University of Alberta, Edmonton, T6G 1C9, AB, Canada.
Pakseresht M; Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, T6G 2E1, AB, Canada.
Rubin D; California State University Fullerton, Fullerton, USA.
Sharma AM; Department of Medicine, University of Alberta, Edmonton, T6G 2C2, AB, Canada.
Tun H; University of Hong Kong School of Public Health, Hong Kong, China.
Walter J; DNational University of Ireland University College Cork, University College Cork, Cork, Ireland.
Newgard CB; Duke University Medical Center, Duke University Hospital, Durham, NC, USA.
Freemark M; Duke University Medical Center, Duke University Hospital, Durham, NC, USA.
Wine E; Department of Pediatrics and Physiology, University of Alberta, Edmonton, T6G 1C9, BA, Canada.
Haqq AM; Department of Pediatrics, University of Alberta, Edmonton, T6G 2E1, AB, Canada. .
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Źródło :
Trials [Trials] 2021 Feb 17; Vol. 22 (1), pp. 148. Date of Electronic Publication: 2021 Feb 17.
Typ publikacji :
Clinical Trial Protocol; Journal Article
MeSH Terms :
Diabetes Mellitus, Type 2*
Insulin Resistance*
Metformin*/adverse effects
Obesity, Morbid*
Adolescent ; Double-Blind Method ; Humans ; Hypoglycemic Agents/adverse effects ; Randomized Controlled Trials as Topic
Czasopismo naukowe
Tytuł :
Improvement in insulin resistance after gastric bypass surgery is correlated with a decline in plasma 2-hydroxybutyric acid.
Autorzy :
Shantavasinkul PC; Division of Nutrition and Biochemical Medicine, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Muehlbauer MJ; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina. Electronic address: .
Bain JR; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina.
Ilkayeva OR; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina.
Craig DM; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina.
Newgard CB; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina.
Svetkey LP; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina.
Shah SH; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina; Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina.
Torquati A; Center for Weight Loss and Bariatric Surgery, Department of General Surgery, Rush University Medical Center, Chicago, Illinois.
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Źródło :
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery [Surg Obes Relat Dis] 2018 Aug; Vol. 14 (8), pp. 1126-1132. Date of Electronic Publication: 2018 Apr 17.
Typ publikacji :
Journal Article
MeSH Terms :
Gastric Bypass/*statistics & numerical data
Hydroxybutyrates/*blood
Insulin Resistance/*physiology
Adult ; Aged ; Cohort Studies ; Female ; Humans ; Male ; Middle Aged
Czasopismo naukowe
Tytuł :
Effect of Progressive Weight Loss on Lactate Metabolism: A Randomized Controlled Trial.
Autorzy :
Chondronikola M; Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Magkos F; Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore.; Clinical Nutrition Research Centre, Agency for Science, Technology, and Research, Singapore.
Yoshino J; Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Okunade AL; Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Patterson BW; Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Muehlbauer MJ; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina, USA.
Newgard CB; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina, USA.
Klein S; Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
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Źródło :
Obesity (Silver Spring, Md.) [Obesity (Silver Spring)] 2018 Apr; Vol. 26 (4), pp. 683-688. Date of Electronic Publication: 2018 Feb 24.
Typ publikacji :
Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Glucose Clamp Technique/*methods
Insulin Resistance/*physiology
Lactates/*metabolism
Weight Loss/*physiology
Adult ; Female ; Humans ; Male
Czasopismo naukowe
Tytuł :
Targeted Metabolomics Demonstrates Distinct and Overlapping Maternal Metabolites Associated With BMI, Glucose, and Insulin Sensitivity During Pregnancy Across Four Ancestry Groups.
Autorzy :
Jacob S; Feinberg School of Medicine, Northwestern University, Chicago, IL.
Nodzenski M; Feinberg School of Medicine, Northwestern University, Chicago, IL.
Reisetter AC; Feinberg School of Medicine, Northwestern University, Chicago, IL.
Bain JR; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC.; Duke University School of Medicine, Durham, NC.
Muehlbauer MJ; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC.; Duke University School of Medicine, Durham, NC.
Stevens RD; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC.; Duke University School of Medicine, Durham, NC.
Ilkayeva OR; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC.; Duke University School of Medicine, Durham, NC.
Lowe LP; Feinberg School of Medicine, Northwestern University, Chicago, IL.
Metzger BE; Feinberg School of Medicine, Northwestern University, Chicago, IL.
Newgard CB; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC.; Duke University School of Medicine, Durham, NC.
Scholtens DM; Feinberg School of Medicine, Northwestern University, Chicago, IL.
Lowe WL Jr; Feinberg School of Medicine, Northwestern University, Chicago, IL .
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Corporate Authors :
HAPO Study Cooperative Research Group
Źródło :
Diabetes care [Diabetes Care] 2017 Jul; Vol. 40 (7), pp. 911-919.
Typ publikacji :
Journal Article
MeSH Terms :
Body Mass Index*
Continental Population Groups*
Insulin Resistance*
Metabolomics*
Blood Glucose/*metabolism
Amino Acids/blood ; Carnitine/analogs & derivatives ; Carnitine/blood ; Cohort Studies ; Female ; Gestational Age ; Glucose Tolerance Test ; Humans ; Hyperglycemia/blood ; Hyperglycemia/diagnosis ; Pregnancy ; Pregnancy Complications/blood ; Pregnancy Complications/diagnosis ; Pregnancy Outcome
Czasopismo naukowe
Tytuł :
Associations of maternal BMI and insulin resistance with the maternal metabolome and newborn outcomes.
Autorzy :
Sandler V; Feinberg School of Medicine, Northwestern University, 420 E. Superior Street, Rubloff 12, Chicago, IL, 60611, USA.
Reisetter AC; Feinberg School of Medicine, Northwestern University, 420 E. Superior Street, Rubloff 12, Chicago, IL, 60611, USA.
Bain JR; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC, USA.; Duke Molecular Physiology Institute, Durham, NC, USA.; Duke University School of Medicine, Durham, NC, USA.
Muehlbauer MJ; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC, USA.; Duke Molecular Physiology Institute, Durham, NC, USA.; Duke University School of Medicine, Durham, NC, USA.
Nodzenski M; Feinberg School of Medicine, Northwestern University, 420 E. Superior Street, Rubloff 12, Chicago, IL, 60611, USA.
Stevens RD; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC, USA.; Duke Molecular Physiology Institute, Durham, NC, USA.; Duke University School of Medicine, Durham, NC, USA.
Ilkayeva O; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC, USA.; Duke Molecular Physiology Institute, Durham, NC, USA.; Duke University School of Medicine, Durham, NC, USA.
Lowe LP; Feinberg School of Medicine, Northwestern University, 420 E. Superior Street, Rubloff 12, Chicago, IL, 60611, USA.
Metzger BE; Feinberg School of Medicine, Northwestern University, 420 E. Superior Street, Rubloff 12, Chicago, IL, 60611, USA.
Newgard CB; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC, USA.; Duke Molecular Physiology Institute, Durham, NC, USA.; Duke University School of Medicine, Durham, NC, USA.
Scholtens DM; Feinberg School of Medicine, Northwestern University, 420 E. Superior Street, Rubloff 12, Chicago, IL, 60611, USA.
Lowe WL Jr; Feinberg School of Medicine, Northwestern University, 420 E. Superior Street, Rubloff 12, Chicago, IL, 60611, USA. .
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Corporate Authors :
HAPO Study Cooperative Research Group
Źródło :
Diabetologia [Diabetologia] 2017 Mar; Vol. 60 (3), pp. 518-530. Date of Electronic Publication: 2016 Dec 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Body Mass Index*
Insulin Resistance/*physiology
Metabolome/*physiology
Adult ; Birth Weight/physiology ; Blood Glucose/metabolism ; Female ; Gestational Age ; Humans ; Obesity/physiopathology ; Pregnancy ; Pregnancy Outcome ; Young Adult
Czasopismo naukowe
Tytuł :
Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans.
Autorzy :
Glynn EL; Sarah W. Stedman Nutrition & Metabolism Center, Duke University Medical Center, Durham, NC, USA.; Duke Molecular Physiology Institute, Duke University Medical Center, 300 North Duke Street, Durham, NC, 27701, USA.
Piner LW; Duke Molecular Physiology Institute, Duke University Medical Center, 300 North Duke Street, Durham, NC, 27701, USA.
Huffman KM; Duke Molecular Physiology Institute, Duke University Medical Center, 300 North Duke Street, Durham, NC, 27701, USA.
Slentz CA; Duke Molecular Physiology Institute, Duke University Medical Center, 300 North Duke Street, Durham, NC, 27701, USA.; Department of Medicine, Duke University Medical Center, Durham, NC, USA.; Department of Cardiology, Duke University Medical Center, Durham, NC, USA.
Elliot-Penry L; Duke Molecular Physiology Institute, Duke University Medical Center, 300 North Duke Street, Durham, NC, 27701, USA.
AbouAssi H; Department of Medicine, Duke University Medical Center, Durham, NC, USA.; Division of Endocrinology, Duke University Medical Center, Durham, NC, USA.
White PJ; Sarah W. Stedman Nutrition & Metabolism Center, Duke University Medical Center, Durham, NC, USA.; Duke Molecular Physiology Institute, Duke University Medical Center, 300 North Duke Street, Durham, NC, 27701, USA.
Bain JR; Sarah W. Stedman Nutrition & Metabolism Center, Duke University Medical Center, Durham, NC, USA.; Duke Molecular Physiology Institute, Duke University Medical Center, 300 North Duke Street, Durham, NC, 27701, USA.; Department of Medicine, Duke University Medical Center, Durham, NC, USA.; Division of Endocrinology, Duke University Medical Center, Durham, NC, USA.
Muehlbauer MJ; Sarah W. Stedman Nutrition & Metabolism Center, Duke University Medical Center, Durham, NC, USA.; Duke Molecular Physiology Institute, Duke University Medical Center, 300 North Duke Street, Durham, NC, 27701, USA.
Ilkayeva OR; Sarah W. Stedman Nutrition & Metabolism Center, Duke University Medical Center, Durham, NC, USA.; Duke Molecular Physiology Institute, Duke University Medical Center, 300 North Duke Street, Durham, NC, 27701, USA.
Stevens RD; Sarah W. Stedman Nutrition & Metabolism Center, Duke University Medical Center, Durham, NC, USA.; Duke Molecular Physiology Institute, Duke University Medical Center, 300 North Duke Street, Durham, NC, 27701, USA.; Department of Medicine, Duke University Medical Center, Durham, NC, USA.; Division of Endocrinology, Duke University Medical Center, Durham, NC, USA.
Porter Starr KN; Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Bales CW; Department of Medicine, Duke University Medical Center, Durham, NC, USA.; Division of Geriatrics, Duke University Medical Center, Durham, NC, USA.; GRECC, Durham VA Medical Center, Durham, NC, USA.
Volpi E; Sealy Center on Aging, University of Texas Medical Branch, Galveston, TX, USA.
Brosnan MJ; The CV and Metabolic Diseases Research Unit, Pfizer, Cambridge, MA, USA.
Trimmer JK; The CV and Metabolic Diseases Research Unit, Pfizer, Cambridge, MA, USA.
Rolph TP; The CV and Metabolic Diseases Research Unit, Pfizer, Cambridge, MA, USA.
Newgard CB; Sarah W. Stedman Nutrition & Metabolism Center, Duke University Medical Center, Durham, NC, USA. Chris.Newgard@dm.duke.edu.; Duke Molecular Physiology Institute, Duke University Medical Center, 300 North Duke Street, Durham, NC, 27701, USA. Chris.Newgard@dm.duke.edu.; Department of Medicine, Duke University Medical Center, Durham, NC, USA. Chris.Newgard@dm.duke.edu.; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA. Chris.Newgard@dm.duke.edu.; Division of Endocrinology, Duke University Medical Center, Durham, NC, USA. Chris.Newgard@dm.duke.edu.
Kraus WE; Duke Molecular Physiology Institute, Duke University Medical Center, 300 North Duke Street, Durham, NC, 27701, USA. .; Department of Medicine, Duke University Medical Center, Durham, NC, USA. .; Department of Cardiology, Duke University Medical Center, Durham, NC, USA. .
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Źródło :
Diabetologia [Diabetologia] 2015 Oct; Vol. 58 (10), pp. 2324-35. Date of Electronic Publication: 2015 Aug 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Resistance Training*
Amino Acids, Branched-Chain/*metabolism
Exercise/*physiology
Glycine/*metabolism
Insulin Resistance/*physiology
Overweight/*metabolism
Adult ; Blood Glucose/metabolism ; Glucose Clamp Technique ; Humans ; Liver/metabolism ; Male ; Middle Aged ; Muscle, Skeletal/metabolism ; Overweight/therapy ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Metabolomic profile associated with insulin resistance and conversion to diabetes in the Insulin Resistance Atherosclerosis Study.
Autorzy :
Palmer ND; Department of Biochemistry (N.D.P., P.A.A., D.W.B.), Center for Genomics and Personalized Medicine Research (N.D.P., P.A.A., D.W.B.), and Center for Diabetes Research (N.D.P., P.A.A., D.W.B.), Wake Forest School of Medicine, Winston Salem, North Carolina 27157; Sarah W. Stedman Nutrition and Metabolism Center (R.D.S., C.B.N.), Duke University School of Medicine, Durham, North Carolina 27710; Department of Biostatistical Sciences (A.A.) and Department of Epidemiology & Prevention (L.E.W.), Wake Forest School of Medicine, Winston Salem, North Carolina 27157; and Department of Physiology and Biophysics (R.N.B.), Keck School of Medicine, University of Southern California, Los Angeles, California 90033.
Stevens RD
Antinozzi PA
Anderson A
Bergman RN
Wagenknecht LE
Newgard CB
Bowden DW
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Źródło :
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2015 Mar; Vol. 100 (3), pp. E463-8. Date of Electronic Publication: 2014 Nov 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Insulin Resistance*/ethnology
Metabolome*
Diabetes Mellitus, Type 2/*metabolism
Prediabetic State/*metabolism
Adult ; African Americans ; African Continental Ancestry Group ; Aged ; Atherosclerosis/ethnology ; Atherosclerosis/metabolism ; Cohort Studies ; Diabetes Mellitus, Type 2/ethnology ; European Continental Ancestry Group ; Female ; Hispanic Americans ; Humans ; Male ; Metabolomics ; Middle Aged ; Prediabetic State/ethnology
Czasopismo naukowe
Tytuł :
Validation of the association between a branched chain amino acid metabolite profile and extremes of coronary artery disease in patients referred for cardiac catheterization.
Autorzy :
Bhattacharya S; Duke Global Health Institute, Durham, NC, USA; Duke Institute of Molecular Physiology, Durham, NC, USA. Electronic address: .
Granger CB; Division of Cardiovascular Medicine, Duke University School of Medicine, Durham, NC, USA; Duke Clinical Research Institute, Durham, NC, USA. Electronic address: christopher..
Craig D; Duke Institute of Molecular Physiology, Durham, NC, USA. Electronic address: .
Haynes C; Duke Institute of Molecular Physiology, Durham, NC, USA. Electronic address: .
Bain J; Duke Institute of Molecular Physiology, Durham, NC, USA. Electronic address: .
Stevens RD; Duke Institute of Molecular Physiology, Durham, NC, USA. Electronic address: .
Hauser ER; Duke Institute of Molecular Physiology, Durham, NC, USA. Electronic address: .
Newgard CB; Duke Institute of Molecular Physiology, Durham, NC, USA. Electronic address: .
Kraus WE; Duke Institute of Molecular Physiology, Durham, NC, USA. Electronic address: .
Newby LK; Division of Cardiovascular Medicine, Duke University School of Medicine, Durham, NC, USA; Duke Clinical Research Institute, Durham, NC, USA. Electronic address: .
Shah SH; Duke Global Health Institute, Durham, NC, USA; Duke Institute of Molecular Physiology, Durham, NC, USA; Division of Cardiovascular Medicine, Duke University School of Medicine, Durham, NC, USA; Duke Clinical Research Institute, Durham, NC, USA. Electronic address: .
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Źródło :
Atherosclerosis [Atherosclerosis] 2014 Jan; Vol. 232 (1), pp. 191-6. Date of Electronic Publication: 2013 Nov 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Validation Study
MeSH Terms :
Insulin Resistance*
Amino Acids, Branched-Chain/*chemistry
Coronary Artery Disease/*blood
Diabetes Mellitus/*blood
Aged ; Albumins/chemistry ; Cardiac Catheterization ; Case-Control Studies ; Coronary Angiography ; Coronary Artery Disease/therapy ; Female ; Humans ; Linear Models ; Male ; Mass Spectrometry ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Phenotype ; Principal Component Analysis
Czasopismo naukowe
Tytuł :
Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance.
Autorzy :
Vernochet C; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02115, USA.
Mourier A
Bezy O
Macotela Y
Boucher J
Rardin MJ
An D
Lee KY
Ilkayeva OR
Zingaretti CM
Emanuelli B
Smyth G
Cinti S
Newgard CB
Gibson BW
Larsson NG
Kahn CR
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Źródło :
Cell metabolism [Cell Metab] 2012 Dec 05; Vol. 16 (6), pp. 765-76. Date of Electronic Publication: 2012 Nov 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Insulin Resistance*
Adipose Tissue, Brown/*metabolism
Adipose Tissue, White/*metabolism
DNA-Binding Proteins/*metabolism
Mitochondria/*metabolism
Mitochondrial Proteins/*metabolism
Obesity/*metabolism
Transcription Factors/*metabolism
Animals ; Cell Line ; DNA, Mitochondrial/metabolism ; DNA-Binding Proteins/deficiency ; DNA-Binding Proteins/genetics ; Electron Transport Complex I/metabolism ; Energy Metabolism ; Mice ; Mice, Knockout ; Mitochondrial Proteins/deficiency ; Mitochondrial Proteins/genetics ; Obesity/pathology ; Oxidative Phosphorylation ; Oxygen/metabolism ; Transcription Factors/deficiency ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
Interplay between lipids and branched-chain amino acids in development of insulin resistance.
Autorzy :
Newgard CB; Sarah W. Stedman Nutrition and Metabolism Center, Department of Pharmacology, Duke University Medical Center, Durham, NC 27704, USA. chris.newgard@duke.edu
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Źródło :
Cell metabolism [Cell Metab] 2012 May 02; Vol. 15 (5), pp. 606-14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Amino Acids, Branched-Chain/*metabolism
Insulin Resistance/*physiology
Lipid Metabolism/*physiology
Animals ; Humans ; Metabolic Diseases/metabolism
Czasopismo naukowe
Tytuł :
The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance.
Autorzy :
Farese RV Jr; Gladstone Institute of Cardiovascular Disease, Department of Medicine, University of California, San Francisco, CA 94158, USA. />Zechner R
Newgard CB
Walther TC
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Źródło :
Cell metabolism [Cell Metab] 2012 May 02; Vol. 15 (5), pp. 570-3.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Fatty Liver/*metabolism
Insulin/*metabolism
Insulin Resistance/*physiology
Liver/*metabolism
Animals ; Humans ; Mice
Czasopismo naukowe
Tytuł :
The metabolic phenotype of Prader-Willi syndrome (PWS) in childhood: heightened insulin sensitivity relative to body mass index.
Autorzy :
Haqq AM; Division of Pediatric Endocrinology, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada. />Muehlbauer MJ
Newgard CB
Grambow S
Freemark M
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Źródło :
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2011 Jan; Vol. 96 (1), pp. E225-32. Date of Electronic Publication: 2010 Oct 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytokines/*blood
Insulin/*metabolism
Insulin Resistance/*physiology
Prader-Willi Syndrome/*metabolism
Blood Glucose/metabolism ; Body Mass Index ; Child ; Humans ; Leptin/blood
Czasopismo naukowe
Tytuł :
Energetics and metabolism in the failing heart: important but poorly understood.
Autorzy :
Turer AT; Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9047, USA. />Malloy CR
Newgard CB
Podgoreanu MV
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Źródło :
Current opinion in clinical nutrition and metabolic care [Curr Opin Clin Nutr Metab Care] 2010 Jul; Vol. 13 (4), pp. 458-65.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Fatty Acids/*metabolism
Glucose/*metabolism
Heart Failure/*metabolism
Insulin Resistance/*physiology
Mitochondria, Heart/*metabolism
Myocardium/*metabolism
Animals ; Energy Metabolism ; Heart Failure/physiopathology ; Humans
Czasopismo naukowe
Tytuł :
Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77.
Autorzy :
Chao LC; Howard Hughes Medical Institute, Department of Pathology and Laboratory Medicine, University of California-Los Angeles, Los Angeles, California, USA.
Wroblewski K
Zhang Z
Pei L
Vergnes L
Ilkayeva OR
Ding SY
Reue K
Watt MJ
Newgard CB
Pilch PF
Hevener AL
Tontonoz P
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Źródło :
Diabetes [Diabetes] 2009 Dec; Vol. 58 (12), pp. 2788-96. Date of Electronic Publication: 2009 Sep 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Insulin Resistance*
Dietary Fats/*adverse effects
Fatty Liver/*metabolism
Glucose/*metabolism
Insulin/*metabolism
Muscle, Skeletal/*metabolism
Nuclear Receptor Subfamily 4, Group A, Member 1/*metabolism
Animals ; Blood Glucose/metabolism ; Calorimetry, Indirect ; Dietary Fats/administration & dosage ; Fatty Liver/etiology ; Glucose Clamp Technique ; Glucose Transporter Type 4/metabolism ; Glycolysis ; Lipid Metabolism ; Mice ; Mice, Knockout ; Nuclear Receptor Subfamily 4, Group A, Member 1/genetics ; Oxygen Consumption ; Phosphorylation ; Receptor, Insulin/metabolism ; Research Design ; Signal Transduction
Czasopismo naukowe
Tytuł :
Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women.
Autorzy :
Huffman KM; Physical Medicine and Rehabilitation, Veterans Affairs Medical Center, Durham, North Carolina, USA. />Shah SH
Stevens RD
Bain JR
Muehlbauer M
Slentz CA
Tanner CJ
Kuchibhatla M
Houmard JA
Newgard CB
Kraus WE
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Źródło :
Diabetes care [Diabetes Care] 2009 Sep; Vol. 32 (9), pp. 1678-83. Date of Electronic Publication: 2009 Jun 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Insulin Resistance/*physiology
Obesity/*blood
Obesity/*physiopathology
Overweight/*blood
Overweight/*physiopathology
Adolescent ; Adult ; Aged ; Amino Acids/blood ; Blood Glucose ; Carnitine/analogs & derivatives ; Carnitine/blood ; Cross-Sectional Studies ; Fatty Acids, Nonesterified/blood ; Female ; Gas Chromatography-Mass Spectrometry ; Humans ; Male ; Middle Aged ; Principal Component Analysis ; Tandem Mass Spectrometry ; Young Adult
Czasopismo naukowe
Tytuł :
A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance.
Autorzy :
Newgard CB; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27710, USA. />An J
Bain JR
Muehlbauer MJ
Stevens RD
Lien LF
Haqq AM
Shah SH
Arlotto M
Slentz CA
Rochon J
Gallup D
Ilkayeva O
Wenner BR
Yancy WS Jr
Eisenson H
Musante G
Surwit RS
Millington DS
Butler MD
Svetkey LP
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Źródło :
Cell metabolism [Cell Metab] 2009 Apr; Vol. 9 (4), pp. 311-26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Metabolomics*
Amino Acids, Branched-Chain/*metabolism
Insulin Resistance/*physiology
Obesity/*metabolism
Thinness/*metabolism
Animals ; Cytokines/metabolism ; Demography ; Dietary Fats/administration & dosage ; Dietary Fats/pharmacology ; Dietary Supplements ; Feeding Behavior/drug effects ; Female ; Hormones/metabolism ; Humans ; Insulin/metabolism ; Male ; Mass Spectrometry ; Metabolome ; Middle Aged ; Rats ; Rats, Wistar ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Mechanisms of disease:Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes.
Autorzy :
Muoio DM; Sarah W. Stedman Nutrition and Metabolism Center, Department of Pharmacology and Cancer Biology and Department of Medicine, Duke University Medical Center, 4321 Medical Park Drive, Durham, North Carolina 27704, USA.
Newgard CB
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Źródło :
Nature reviews. Molecular cell biology [Nat Rev Mol Cell Biol] 2008 Mar; Vol. 9 (3), pp. 193-205.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Diabetes Mellitus, Type 2/*metabolism
Diabetes Mellitus, Type 2/*pathology
Insulin Resistance/*physiology
Insulin-Secreting Cells/*pathology
Animals ; Diabetes Mellitus, Type 2/genetics ; Glucose/metabolism ; Humans ; Insulin/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance.
Autorzy :
Koves TR; Sarah W. Stedman Nutrition and Metabolism Center, Department of Medicine, Duke University, Durham, NC 27710, USA.
Ussher JR
Noland RC
Slentz D
Mosedale M
Ilkayeva O
Bain J
Stevens R
Dyck JR
Newgard CB
Lopaschuk GD
Muoio DM
Pokaż więcej
Źródło :
Cell metabolism [Cell Metab] 2008 Jan; Vol. 7 (1), pp. 45-56.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Insulin Resistance*
Fatty Acids/*metabolism
Mitochondria/*metabolism
Muscle, Skeletal/*metabolism
Animals ; Blood Glucose/metabolism ; Carboxy-Lyases/genetics ; Carboxy-Lyases/metabolism ; Cell Line ; Dietary Fats/administration & dosage ; Glucose Tolerance Test ; Lipid Metabolism ; Mice ; Mice, Knockout ; Muscle Fibers, Skeletal/metabolism ; Muscle, Skeletal/pathology ; Obesity/metabolism ; Obesity/pathology ; Oxidation-Reduction ; Rats
Czasopismo naukowe
Tytuł :
Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle.
Autorzy :
Levin MC; Gladstone Institute of Cardiovascular Disease, 1650 Owens St., San Francisco, CA 94158, USA.
Monetti M
Watt MJ
Sajan MP
Stevens RD
Bain JR
Newgard CB
Farese RV Sr
Farese RV Jr
Pokaż więcej
Źródło :
American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2007 Dec; Vol. 293 (6), pp. E1772-81. Date of Electronic Publication: 2007 Oct 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Diacylglycerol O-Acyltransferase/*genetics
Insulin Resistance/*physiology
Lipids/*analysis
Muscle Fibers, Fast-Twitch/*metabolism
Acyl Coenzyme A/analysis ; Acyl Coenzyme A/metabolism ; Age Factors ; Animals ; Blood Glucose/metabolism ; Ceramides/analysis ; Ceramides/metabolism ; Diacylglycerol O-Acyltransferase/metabolism ; Diglycerides/analysis ; Diglycerides/metabolism ; Gene Expression/drug effects ; Glucose/metabolism ; Glucose Intolerance/blood ; Hypoglycemic Agents/pharmacology ; Insulin/pharmacology ; Insulin Resistance/genetics ; Isoenzymes/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Muscle Fibers, Fast-Twitch/chemistry ; Muscle Fibers, Fast-Twitch/drug effects ; Muscle, Skeletal/chemistry ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Protein Kinase C/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Triglycerides/analysis ; Triglycerides/metabolism
Czasopismo naukowe
Tytuł :
Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver.
Autorzy :
Monetti M; Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, CA 94158, USA.
Levin MC
Watt MJ
Sajan MP
Marmor S
Hubbard BK
Stevens RD
Bain JR
Newgard CB
Farese RV Sr
Hevener AL
Farese RV Jr
Pokaż więcej
Źródło :
Cell metabolism [Cell Metab] 2007 Jul; Vol. 6 (1), pp. 69-78.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Insulin Resistance*
Diacylglycerol O-Acyltransferase/*metabolism
Fatty Liver/*metabolism
Liver/*metabolism
Animals ; Apolipoprotein C-I ; Blood Glucose/analysis ; Diacylglycerol O-Acyltransferase/genetics ; Fatty Liver/genetics ; Fatty Liver/pathology ; Glucose Clamp Technique ; Glucose Intolerance ; Humans ; Hyperinsulinism ; Insulin/metabolism ; Liver/cytology ; Liver/pathology ; Macrophages, Peritoneal/cytology ; Macrophages, Peritoneal/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Triglycerides/metabolism
Czasopismo naukowe

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